IS607 family transposase [Selenomonas ruminantium]
Protein Classification
IS607 family transposase( domain architecture ID 16669846)
IS607 family transposase binds to the end of a transposon and catalyzes the movement of the transposon to another part of the genome by a cut and paste mechanism or a replicative transposition mechanism
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||
| transpos_IS607 super family | cl41297 | IS607 family transposase; |
7-190 | 4.51e-75 | ||||
IS607 family transposase; The actual alignment was detected with superfamily member NF033518: Pssm-ID: 468054 [Multi-domain] Cd Length: 187 Bit Score: 224.44 E-value: 4.51e-75
|
||||||||
| Name | Accession | Description | Interval | E-value | ||||
| transpos_IS607 | NF033518 | IS607 family transposase; |
7-190 | 4.51e-75 | ||||
IS607 family transposase; Pssm-ID: 468054 [Multi-domain] Cd Length: 187 Bit Score: 224.44 E-value: 4.51e-75
|
||||||||
| COG2452 | COG2452 | Predicted site-specific integrase-resolvase [Mobilome: prophages, transposons]; |
4-188 | 1.54e-70 | ||||
Predicted site-specific integrase-resolvase [Mobilome: prophages, transposons]; Pssm-ID: 441988 [Multi-domain] Cd Length: 178 Bit Score: 212.55 E-value: 1.54e-70
|
||||||||
| SR_IS607_transposase_like | cd03769 | Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members ... |
60-192 | 1.28e-51 | ||||
Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. This subfamily is composed of proteins that catalyze the transposition of insertion sequence (IS) elements such as IS607 from Helicobacter and IS1535 from Mycobacterium, and similar proteins from other bacteria and several archaeal species. IS elements are DNA segments that move to new sites in prokaryotic and eukaryotic genomes causing insertion mutations and gene rearrangements. Pssm-ID: 239738 Cd Length: 134 Bit Score: 162.82 E-value: 1.28e-51
|
||||||||
| Resolvase | smart00857 | Resolvase, N terminal domain; The N-terminal domain of the resolvase family contains the ... |
60-201 | 2.41e-19 | ||||
Resolvase, N terminal domain; The N-terminal domain of the resolvase family contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase. Pssm-ID: 214861 [Multi-domain] Cd Length: 148 Bit Score: 80.36 E-value: 2.41e-19
|
||||||||
| Resolvase | pfam00239 | Resolvase, N terminal domain; The N-terminal domain of the resolvase family (this family) ... |
60-199 | 3.87e-18 | ||||
Resolvase, N terminal domain; The N-terminal domain of the resolvase family (this family) contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase - see pfam02796. Pssm-ID: 425548 [Multi-domain] Cd Length: 144 Bit Score: 77.31 E-value: 3.87e-18
|
||||||||
| recomb_XisF | NF041201 | fdxN element excision recombinase XisF; |
60-191 | 1.62e-09 | ||||
fdxN element excision recombinase XisF; Pssm-ID: 469105 [Multi-domain] Cd Length: 463 Bit Score: 56.51 E-value: 1.62e-09
|
||||||||
| Name | Accession | Description | Interval | E-value | ||||
| transpos_IS607 | NF033518 | IS607 family transposase; |
7-190 | 4.51e-75 | ||||
IS607 family transposase; Pssm-ID: 468054 [Multi-domain] Cd Length: 187 Bit Score: 224.44 E-value: 4.51e-75
|
||||||||
| COG2452 | COG2452 | Predicted site-specific integrase-resolvase [Mobilome: prophages, transposons]; |
4-188 | 1.54e-70 | ||||
Predicted site-specific integrase-resolvase [Mobilome: prophages, transposons]; Pssm-ID: 441988 [Multi-domain] Cd Length: 178 Bit Score: 212.55 E-value: 1.54e-70
|
||||||||
| SR_IS607_transposase_like | cd03769 | Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members ... |
60-192 | 1.28e-51 | ||||
Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. This subfamily is composed of proteins that catalyze the transposition of insertion sequence (IS) elements such as IS607 from Helicobacter and IS1535 from Mycobacterium, and similar proteins from other bacteria and several archaeal species. IS elements are DNA segments that move to new sites in prokaryotic and eukaryotic genomes causing insertion mutations and gene rearrangements. Pssm-ID: 239738 Cd Length: 134 Bit Score: 162.82 E-value: 1.28e-51
|
||||||||
| Resolvase | smart00857 | Resolvase, N terminal domain; The N-terminal domain of the resolvase family contains the ... |
60-201 | 2.41e-19 | ||||
Resolvase, N terminal domain; The N-terminal domain of the resolvase family contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase. Pssm-ID: 214861 [Multi-domain] Cd Length: 148 Bit Score: 80.36 E-value: 2.41e-19
|
||||||||
| Resolvase | pfam00239 | Resolvase, N terminal domain; The N-terminal domain of the resolvase family (this family) ... |
60-199 | 3.87e-18 | ||||
Resolvase, N terminal domain; The N-terminal domain of the resolvase family (this family) contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase - see pfam02796. Pssm-ID: 425548 [Multi-domain] Cd Length: 144 Bit Score: 77.31 E-value: 3.87e-18
|
||||||||
| Ser_Recombinase | cd00338 | Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or ... |
63-191 | 3.59e-13 | ||||
Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and serine recombinase. Serine recombinases demonstrate functional versatility and include resolvases, invertases, integrases, and transposases. Resolvases and invertases (i.e. Tn3, gamma-delta, Tn5044 resolvases, Gin and Hin invertases) in this family contain a C-terminal DNA binding domain and comprise a major phylogenic group. Also included are phage- and bacterial-encoded recombinases such as phiC31 integrase, SpoIVCA excisionase, and Tn4451 TnpX transposase. These integrases and transposases have larger C-terminal domains compared to resolvases/invertases and are referred to as large serine recombinases. Also belonging to this family are proteins with N-terminal DNA binding domains similar to IS607- and IS1535-transposases from Helicobacter and Mycobacterium. Pssm-ID: 238206 [Multi-domain] Cd Length: 137 Bit Score: 63.82 E-value: 3.59e-13
|
||||||||
| SpoIVCA | COG1961 | Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and ... |
60-204 | 1.39e-10 | ||||
Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and repair]; Pssm-ID: 441564 [Multi-domain] Cd Length: 388 Bit Score: 59.65 E-value: 1.39e-10
|
||||||||
| recomb_XisF | NF041201 | fdxN element excision recombinase XisF; |
60-191 | 1.62e-09 | ||||
fdxN element excision recombinase XisF; Pssm-ID: 469105 [Multi-domain] Cd Length: 463 Bit Score: 56.51 E-value: 1.62e-09
|
||||||||
| SR_ResInv | cd03768 | Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members ... |
60-156 | 1.32e-08 | ||||
Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1. Pssm-ID: 239737 [Multi-domain] Cd Length: 126 Bit Score: 51.33 E-value: 1.32e-08
|
||||||||
| HTH_BmrR | cd01107 | Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Helix-turn-helix (HTH) ... |
5-47 | 2.43e-06 | ||||
Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Helix-turn-helix (HTH) multidrug-efflux transporter transcription regulator, BmrR and YdfL of Bacillus subtilis, and related proteins; N-terminal domain. Bmr is a membrane protein which causes the efflux of a variety of toxic substances and antibiotics. BmrR is comprised of two distinct domains that harbor a regulatory (effector-binding) site and an active (DNA-binding) site. The conserved N-terminal domain contains a winged HTH motif that mediates DNA binding, while the C-terminal domain binds coactivating, toxic compounds. BmrR shares the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. Pssm-ID: 133382 [Multi-domain] Cd Length: 108 Bit Score: 44.82 E-value: 2.43e-06
|
||||||||
| HTH_BmrR-like | cd04768 | Helix-Turn-Helix DNA binding domain of BmrR-like transcription regulators; Helix-turn-helix ... |
4-51 | 6.40e-06 | ||||
Helix-Turn-Helix DNA binding domain of BmrR-like transcription regulators; Helix-turn-helix (HTH) BmrR-like transcription regulators (TipAL, Mta, SkgA, BmrR, and BltR), N-terminal domain. These proteins have been shown to regulate expression of specific regulons in response to various toxic substances, antibiotics, or oxygen radicals in Bacillus subtilis, Streptomyces, and Caulobacter crescentus. They are comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain HTH motifs that mediate DNA binding, while the C-terminal domains are often unrelated and bind specific coactivator molecules. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. Pssm-ID: 133396 [Multi-domain] Cd Length: 96 Bit Score: 43.11 E-value: 6.40e-06
|
||||||||
| HTH_TipAL-Mta | cd01106 | Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; ... |
5-48 | 8.11e-06 | ||||
Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Helix-turn-helix (HTH) TipAL, Mta, and SkgA transcription regulators, and related proteins, N-terminal domain. TipAL regulates resistance to and activation by numerous cyclic thiopeptide antibiotics, such as thiostrepton. Mta is a global transcriptional regulator; the N-terminal DNA-binding domain of Mta interacts directly with the promoters of mta, bmr, blt, and ydfK, and induces transcription of these multidrug-efflux transport genes. SkgA has been shown to control stationary-phase expression of catalase-peroxidase in Caulobacter crescentus. These proteins are comprised of distinct domains that harbor an N-terminal active (DNA-binding) site and a regulatory (effector-binding) site. The conserved N-terminal domain of these transcription regulators contains winged HTH motifs that mediate DNA binding. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. Unique to this family, is a TipAL-like, lineage specific Bacilli subgroup, which has five conserved cysteines in the C-terminus of the protein. Pssm-ID: 133381 [Multi-domain] Cd Length: 103 Bit Score: 43.24 E-value: 8.11e-06
|
||||||||
| MerR | pfam00376 | MerR family regulatory protein; |
5-42 | 8.94e-06 | ||||
MerR family regulatory protein; Pssm-ID: 425647 [Multi-domain] Cd Length: 38 Bit Score: 41.25 E-value: 8.94e-06
|
||||||||
| SoxR | COG0789 | DNA-binding transcriptional regulator, MerR family [Transcription]; |
6-47 | 3.43e-05 | ||||
DNA-binding transcriptional regulator, MerR family [Transcription]; Pssm-ID: 440552 [Multi-domain] Cd Length: 100 Bit Score: 41.43 E-value: 3.43e-05
|
||||||||
| HTH_BltR | cd04782 | Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Helix-turn-helix (HTH) ... |
5-51 | 7.01e-05 | ||||
Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Helix-turn-helix (HTH) multidrug-efflux transporter transcription regulator, BltR (BmrR-like transporter) of Bacillus subtilis, and related proteins; N-terminal domain. Blt, like Bmr, is a membrane protein which causes the efflux of a variety of toxic substances and antibiotics. These regulators are comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain predicted winged HTH motifs that mediate DNA binding, while the C-terminal domains are often unrelated and bind specific coactivator molecules. They share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. Pssm-ID: 133409 [Multi-domain] Cd Length: 97 Bit Score: 40.29 E-value: 7.01e-05
|
||||||||
| HTH_MERR | smart00422 | helix_turn_helix, mercury resistance; |
5-51 | 2.66e-04 | ||||
helix_turn_helix, mercury resistance; Pssm-ID: 197716 Cd Length: 70 Bit Score: 37.88 E-value: 2.66e-04
|
||||||||
| HTH_NolA-AlbR | cd04788 | Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; ... |
6-48 | 3.94e-04 | ||||
Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Helix-turn-helix (HTH) transcription regulators NolA and AlbR, N-terminal domain. In Bradyrhizobium (Arachis) sp. NC92, NolA is required for efficient nodulation of host plants. In Xanthomonas albilineans, AlbR regulates the expression of the pathotoxin, albicidin. These proteins are putatively comprised of distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain predicted winged HTH motifs that mediate DNA binding, while the C-terminal domains are often unrelated and bind specific coactivator molecules. They share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. Pssm-ID: 133415 [Multi-domain] Cd Length: 96 Bit Score: 38.13 E-value: 3.94e-04
|
||||||||
| MerR_1 | pfam13411 | MerR HTH family regulatory protein; |
5-50 | 4.78e-04 | ||||
MerR HTH family regulatory protein; Pssm-ID: 463870 Cd Length: 66 Bit Score: 37.15 E-value: 4.78e-04
|
||||||||
| HTH_MerR-like | cd00592 | Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Helix-turn-helix ... |
5-47 | 5.40e-04 | ||||
Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Helix-turn-helix (HTH) MerR-like transcription regulator, N-terminal domain. The MerR family transcription regulators have been shown to mediate responses to stress including exposure to heavy metals, drugs, or oxygen radicals in eubacterial and some archaeal species. They regulate transcription of multidrug/metal ion transporter genes and oxidative stress regulons by reconfiguring the spacer between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates. Pssm-ID: 133378 [Multi-domain] Cd Length: 100 Bit Score: 37.99 E-value: 5.40e-04
|
||||||||
| SR_TndX_transposase | cd03770 | Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of ... |
60-190 | 5.71e-04 | ||||
Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. TndX mediates the excision and circularization of the conjugative transposon Tn5397 from Clostridium difficile. TnpX is responsible for the movement of the nonconjugative chloramphenicol resistance elements of the Tn4451/3 family. Mobile genetic elements such as transposons are important vehicles for the transmission of virulence and antibiotic resistance in many microorganisms. Pssm-ID: 239739 [Multi-domain] Cd Length: 140 Bit Score: 38.89 E-value: 5.71e-04
|
||||||||
| HTH_MerR-trunc | cd04762 | Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Proteins in this family ... |
4-50 | 6.59e-04 | ||||
Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Proteins in this family mostly have a truncated helix-turn-helix (HTH) MerR-like domain. They lack a portion of the C-terminal region, called Wing 2 and the long dimerization helix that is typically present in MerR-like proteins. These truncated domains are found in response regulator receiver (REC) domain proteins (i.e., CheY), cytosine-C5 specific DNA methylases, IS607 transposase-like proteins, and RacA, a bacterial protein that anchors chromosomes to cell poles. Pssm-ID: 133390 [Multi-domain] Cd Length: 49 Bit Score: 36.41 E-value: 6.59e-04
|
||||||||
| HTH_TioE_rpt2 | cd04773 | Second Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Putative ... |
5-49 | 4.52e-03 | ||||
Second Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Putative helix-turn-helix (HTH) regulatory protein, TioE, and related proteins. TioE is part of the thiocoraline gene cluster, which is involved in the biosynthesis of the antitumor thiocoraline from the marine actinomycete, Micromonospora. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. Proteins in this family are unique within the MerR superfamily in that they are composed of just two adjacent MerR-like N-terminal domains; this CD mainly contains the C-terminal or second repeat (rpt2) of these tandem MerR-like domain proteins. Pssm-ID: 133400 Cd Length: 108 Bit Score: 35.42 E-value: 4.52e-03
|
||||||||
| HTH_MlrA-CarA | cd01104 | Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; ... |
5-47 | 6.44e-03 | ||||
Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Helix-turn-helix (HTH) transcription regulator MlrA (merR-like regulator A), N-terminal domain. The MlrA protein, also known as YehV, has been shown to control cell-cell aggregation by co-regulating the expression of curli and extracellular matrix production in Escherichia coli and Salmonella typhimurium. Its close homolog, CarA from Myxococcus xanthus, is involved in activation of the carotenoid biosynthesis genes by light. These proteins belong to the MerR superfamily of transcription regulators that promote expression of several stress regulon genes by reconfiguring the spacer between the -35 and -10 promoter elements. Their conserved N-terminal domains contain predicted HTH motifs that mediate DNA binding, while the dissimilar C-terminal domains bind specific coactivator molecules. Many MlrA- and CarA-like proteins in this group appear to lack the long dimerization helix seen in the N-terminal domains of typical MerR-like proteins. Pssm-ID: 133379 Cd Length: 68 Bit Score: 34.14 E-value: 6.44e-03
|
||||||||
| Blast search parameters | ||||
|
