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Conserved domains on  [gi|503486013|ref|WP_013720674|]
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MULTISPECIES: ABC transporter permease [Methanothrix]

Protein Classification

ABC transporter permease( domain architecture ID 11427312)

ABC transporter permease similar to ABC oligopeptide transporter permease proteins (OppB, AppB, and AmiC), the transmembrane subunits (TM) found in periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporters which generally bind type 2 PBPs

Gene Ontology:  GO:0055085
PubMed:  18535149|17723295
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DppB COG0601
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 12-326 2.11e-86

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


:

Pssm-ID: 440366 [Multi-domain]  Cd Length: 314  Bit Score: 262.31  E-value: 2.11e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013  12 LSYIIALLAIFALNFILPRMMPGNPLQAIYGDEAlvamTPQMEVHLTELFALDKSWSEQMVAYVLALLQGNLGFSYYYKD 91
Cdd:COG0601   10 LQAIPVLLGVSTLVFLLLRLLPGDPAAALLGPRA----TPEAIAALRAELGLDQPLLVQYLDWLGGLLRGDLGTSFVYGR 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013  92 EVSSVIMGALPWTLLLVGLSLLIATVVGVMLGIESGYRRGERIDRGLLAGLMLLGGLPDFFLGIVLLLIFGVSLNLFPLS 171
Cdd:COG0601   86 PVSDLIAERLPVTLELALLALLLALLIGIPLGILAALRRGSWLDRLITVLALLGISIPSFWLGLLLILLFAVKLGWLPVS 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013 172 GALTPysglegFPLVADIARHLALPLAALVLVDLGGIYLLTRNTVVTILKEGFMLTARAKGCSEFCLRYSHAGRNALLPV 251
Cdd:COG0601  166 GRVSP------WEDFLDALRHLILPALTLALGSLAGIARLTRSSMLEVLGQDYVRTARAKGLSERRVLLRHALRNALIPV 239

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 503486013 252 TTATGLRIPQLITGALFIEIIFSYPGLGLMLRTALDARDYPLIQGILLLVTVTVLFANLFVDQIYKRLDPRTRYA 326
Cdd:COG0601  240 VTVLGLQLGGLLGGAVVVETVFSWPGLGRLLVDAILNRDYPVVQGIVLLIAVLVVLVNLLVDLLYALLDPRIRLG 314
 
Name Accession Description Interval E-value
DppB COG0601
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 12-326 2.11e-86

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


Pssm-ID: 440366 [Multi-domain]  Cd Length: 314  Bit Score: 262.31  E-value: 2.11e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013  12 LSYIIALLAIFALNFILPRMMPGNPLQAIYGDEAlvamTPQMEVHLTELFALDKSWSEQMVAYVLALLQGNLGFSYYYKD 91
Cdd:COG0601   10 LQAIPVLLGVSTLVFLLLRLLPGDPAAALLGPRA----TPEAIAALRAELGLDQPLLVQYLDWLGGLLRGDLGTSFVYGR 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013  92 EVSSVIMGALPWTLLLVGLSLLIATVVGVMLGIESGYRRGERIDRGLLAGLMLLGGLPDFFLGIVLLLIFGVSLNLFPLS 171
Cdd:COG0601   86 PVSDLIAERLPVTLELALLALLLALLIGIPLGILAALRRGSWLDRLITVLALLGISIPSFWLGLLLILLFAVKLGWLPVS 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013 172 GALTPysglegFPLVADIARHLALPLAALVLVDLGGIYLLTRNTVVTILKEGFMLTARAKGCSEFCLRYSHAGRNALLPV 251
Cdd:COG0601  166 GRVSP------WEDFLDALRHLILPALTLALGSLAGIARLTRSSMLEVLGQDYVRTARAKGLSERRVLLRHALRNALIPV 239

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 503486013 252 TTATGLRIPQLITGALFIEIIFSYPGLGLMLRTALDARDYPLIQGILLLVTVTVLFANLFVDQIYKRLDPRTRYA 326
Cdd:COG0601  240 VTVLGLQLGGLLGGAVVVETVFSWPGLGRLLVDAILNRDYPVVQGIVLLIAVLVVLVNLLVDLLYALLDPRIRLG 314
PRK10914 PRK10914
dipeptide ABC transporter permease DppB;
15-327 7.12e-41

dipeptide ABC transporter permease DppB;


Pssm-ID: 182834 [Multi-domain]  Cd Length: 339  Bit Score: 145.72  E-value: 7.12e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013  15 IIALLAIFALNFILPRMMPGNPLQAIYGDEAlvaMTPQMEVHLTELFALDKSWSEQMVAYVLALLQGNLGFSYYYKDEVS 94
Cdd:PRK10914  13 IPTFIGITLLTFAFVHMIPGDPVMIMAGERG---ISPERHAQLLAELGLDKPMWQQYLHYIWGVMHGDLGISLKSRIPVW 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013  95 SVIMGALPWTLLLVGLSLLIATVVGVMLGIESGYRRGERIDRGLLAGLMLLGGLPDFFLGIVLLLIFGVSLNLFPLSGA- 173
Cdd:PRK10914  90 DEFVPRFKATLELGVCAMIFAVAVGIPVGVLAAVKRGSIFDHTAVGLALTGYSMPIFWWGMMLIMLVSVHWNLTPVSGRv 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013 174 -----LTPYSGLEGFPLV-----------ADIARHLALPLAALVLVDLGGIYLLTRNTVVTILKEGFMLTARAKGCSEFC 237
Cdd:PRK10914 170 sdmvfLDDSNPLTGFMLIdtaiwgedgnfIDAVAHMILPAIVLGTIPLAVIVRMTRSSMLEVLGEDYIRTARAKGLTRMR 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013 238 LRYSHAGRNALLPVTTATGLRIPQLITGALFIEIIFSYPGLGLMLRTALDARDYPLIQGILLLVTVTVLFANLFVDQIYK 317
Cdd:PRK10914 250 VIIVHALRNAMLPVVTVIGLQVGTLLAGAILTETIFSWPGLGRWLIDALQRRDYPVVQGGVLLVATMIILVNLLVDLLYG 329

                        330
                 ....*....|
gi 503486013 318 RLDPRTRYAH 327
Cdd:PRK10914 330 VVNPRIRHKK 339
nickel_nikB TIGR02789
nickel ABC transporter, permease subunit NikB; This family consists of the NikB family of ...
 12-324 6.66e-36

nickel ABC transporter, permease subunit NikB; This family consists of the NikB family of nickel ABC transporter permeases. Operons that contain this protein also contain a homologous permease subunit NikC. Nickel is used in cells as part of urease or certain hydrogenases or superoxide dismutases. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 131836 [Multi-domain]  Cd Length: 314  Bit Score: 131.81  E-value: 6.66e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013   12 LSYIIALLAIFALNFILPRMMPGNPLQAiYGDEALVAMTPQMEVHLTELFALDKSWSEQMVAYVLALLQGNLGFSYYYKD 91
Cdd:TIGR02789  10 LLLIPVVLAASLLAFILIHLGPSDPAED-YLRLSHIPPTDEAIADMRHSLGLDQPLYVQYFHWLWNALHLDFGISYISDR 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013   92 EVSSVIMGALPWTLLLVGLSLLIATVVGVMLGIESGYRRGERIDRGLLAGLMLLGGLPDFFLGIVLLLIFGVSLNLFPLS 171
Cdd:TIGR02789  89 PVLDEIARSLPATLELAGFALVIVVLVSVPLGILAARYRDRLPDHAVRFIIFLGVSIPNFWLAFLLVWGFSVYLNLLPTN 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013  172 GALTpysglegfplvadiARHLALPLAALVLVDLGGIYLLTRNTVVTILKEGFMLTARAKGCSEFCLRYSHAGRNALLPV 251
Cdd:TIGR02789 169 GAGT--------------WQHLVLPAVTLALMSVSIYARLLRASMLDNMQERYVTYARVRGIKERWVIRRHILRNAILPM 234

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 503486013  252 TTATGLRIPQLITGALFIEIIFSYPGLGLMLRTALDARDYPLIQGILLLVTVTVLFANLFVDQIYKRLDPRTR 324
Cdd:TIGR02789 235 ITALGMHIGELLGGTFVIENIFSWPGVGRYAISAIFNRDYPVIQCYTLLMGLLFVFCNLIVDLFQALLDPRIR 307
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 119-325 2.11e-18

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 81.58  E-value: 2.11e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013  119 GVMLGIESGYRRGERIDRGLLAGLMLLGGLPDFFLGIVLLLIFGVSLNLFPLSGALTPYSGLEGFPLvadiarhlalpla 198
Cdd:pfam00528   1 GIPLGIIAALRRGRRLDRLLRPLIDLLQALPSFVLAILLVVIAILSILGHGILPAIILALLGWAGYA------------- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013  199 alvlvdlggiyLLTRNTVVTILKEGFMLTARAKGCSEFCLRYSHAGRNALLPVTTATGLRIPQLITGALFIEIIFSYPGL 278
Cdd:pfam00528  68 -----------RLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGL 136

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 503486013  279 GLMLRTALDARDYPLIQGILLLVTVTVLFANLFVDQIYKRLDPRTRY 325
Cdd:pfam00528 137 GLLLIEAILGYDYPEIQGPVLAAALILLLLNLLVDILQRLLDPRVRK 183
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 101-310 6.15e-05

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 43.04  E-value: 6.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013 101 LPWTLLLVGLSLLIATVVGVMLGIESGYRRGeRIDRGLLAGLMLLGGLPDFFLGIVLLLIFGVSLNLfplsgaltpysgl 180
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRG-KLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGW------------- 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013 181 egfplvaDIARHLALPLAALVLVDLGGIYLLTRNTVVTILKEGFMLTARAKGCSEFCLRYSHAGRNALLPVTTATGLRIP 260
Cdd:cd06261   67 -------GILPGLGLPALILALLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFA 139

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 503486013 261 QLITGALFIEIIFSYPGLGL-MLRTALDARDYPLIQGILLLVTVTVLFANL 310
Cdd:cd06261  140 RALGEFALVSFLGGGEAPGPgTGLLLIFAILFPGDLGVAAAVALILLLLSL 190
 
Name Accession Description Interval E-value
DppB COG0601
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 12-326 2.11e-86

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


Pssm-ID: 440366 [Multi-domain]  Cd Length: 314  Bit Score: 262.31  E-value: 2.11e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013  12 LSYIIALLAIFALNFILPRMMPGNPLQAIYGDEAlvamTPQMEVHLTELFALDKSWSEQMVAYVLALLQGNLGFSYYYKD 91
Cdd:COG0601   10 LQAIPVLLGVSTLVFLLLRLLPGDPAAALLGPRA----TPEAIAALRAELGLDQPLLVQYLDWLGGLLRGDLGTSFVYGR 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013  92 EVSSVIMGALPWTLLLVGLSLLIATVVGVMLGIESGYRRGERIDRGLLAGLMLLGGLPDFFLGIVLLLIFGVSLNLFPLS 171
Cdd:COG0601   86 PVSDLIAERLPVTLELALLALLLALLIGIPLGILAALRRGSWLDRLITVLALLGISIPSFWLGLLLILLFAVKLGWLPVS 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013 172 GALTPysglegFPLVADIARHLALPLAALVLVDLGGIYLLTRNTVVTILKEGFMLTARAKGCSEFCLRYSHAGRNALLPV 251
Cdd:COG0601  166 GRVSP------WEDFLDALRHLILPALTLALGSLAGIARLTRSSMLEVLGQDYVRTARAKGLSERRVLLRHALRNALIPV 239

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 503486013 252 TTATGLRIPQLITGALFIEIIFSYPGLGLMLRTALDARDYPLIQGILLLVTVTVLFANLFVDQIYKRLDPRTRYA 326
Cdd:COG0601  240 VTVLGLQLGGLLGGAVVVETVFSWPGLGRLLVDAILNRDYPVVQGIVLLIAVLVVLVNLLVDLLYALLDPRIRLG 314
PRK10914 PRK10914
dipeptide ABC transporter permease DppB;
15-327 7.12e-41

dipeptide ABC transporter permease DppB;


Pssm-ID: 182834 [Multi-domain]  Cd Length: 339  Bit Score: 145.72  E-value: 7.12e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013  15 IIALLAIFALNFILPRMMPGNPLQAIYGDEAlvaMTPQMEVHLTELFALDKSWSEQMVAYVLALLQGNLGFSYYYKDEVS 94
Cdd:PRK10914  13 IPTFIGITLLTFAFVHMIPGDPVMIMAGERG---ISPERHAQLLAELGLDKPMWQQYLHYIWGVMHGDLGISLKSRIPVW 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013  95 SVIMGALPWTLLLVGLSLLIATVVGVMLGIESGYRRGERIDRGLLAGLMLLGGLPDFFLGIVLLLIFGVSLNLFPLSGA- 173
Cdd:PRK10914  90 DEFVPRFKATLELGVCAMIFAVAVGIPVGVLAAVKRGSIFDHTAVGLALTGYSMPIFWWGMMLIMLVSVHWNLTPVSGRv 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013 174 -----LTPYSGLEGFPLV-----------ADIARHLALPLAALVLVDLGGIYLLTRNTVVTILKEGFMLTARAKGCSEFC 237
Cdd:PRK10914 170 sdmvfLDDSNPLTGFMLIdtaiwgedgnfIDAVAHMILPAIVLGTIPLAVIVRMTRSSMLEVLGEDYIRTARAKGLTRMR 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013 238 LRYSHAGRNALLPVTTATGLRIPQLITGALFIEIIFSYPGLGLMLRTALDARDYPLIQGILLLVTVTVLFANLFVDQIYK 317
Cdd:PRK10914 250 VIIVHALRNAMLPVVTVIGLQVGTLLAGAILTETIFSWPGLGRWLIDALQRRDYPVVQGGVLLVATMIILVNLLVDLLYG 329

                        330
                 ....*....|
gi 503486013 318 RLDPRTRYAH 327
Cdd:PRK10914 330 VVNPRIRHKK 339
PRK15081 PRK15081
glutathione ABC transporter permease GsiC; Provisional
 12-325 2.89e-38

glutathione ABC transporter permease GsiC; Provisional


Pssm-ID: 185039 [Multi-domain]  Cd Length: 306  Bit Score: 137.92  E-value: 2.89e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013  12 LSYIIALLAIFALNFILPRMMPGNPLQAIYG---DEALVAMTPQMevhltelFALDKSWSEQMVAYVLALLQGNLGFSYY 88
Cdd:PRK15081  10 LGLIPTLLIVAVLVFLFVHLLPGDPARLAAGpeaDAQVVALVRQQ-------LGLDQPLPHQFWHYISNALQGDFGTSMV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013  89 YKDEVSSVIMGALPWTLLLVGLSLLIATVVGVMLGIESGYRRGERIDRGLLAGLMLLGGLPDFFLGIVLLLIFGVSLNLF 168
Cdd:PRK15081  83 SRRPVSEEIASRFMPTLWLTITSMVWAVIFGMAIGIASAVWRNRWPDRLGMTLAVSGISFPAFALGMLLMQVFSVELGWL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013 169 PLSGA------LTPYSGLeGFPLVADIARhlalplaalvlvdlggiylLTRNTVVTILKEGFMLTARAKGCSEFCLRYSH 242
Cdd:PRK15081 163 PTVGAdswqhyILPSLTL-GAAVAAVMAR-------------------FTRASFVEVLSEDYMRTARAKGVSETWVVLKH 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013 243 AGRNALLPVTTATGLRIPQLITGALFIEIIFSYPGLGLMLRTALDARDYPLIQGILLLVTVTVLFANLFVDQIYKRLDPR 322
Cdd:PRK15081 223 GLRNAMIPVVTMMGLQFGFLLGGSIVVEKVFNWPGLGRLLVDSVEMRDYPVIQAEVLLFSLEFILINLVVDVLYAAINPA 302


                 ...
gi 503486013 323 TRY 325
Cdd:PRK15081 303 IRY 305
nickel_nikB TIGR02789
nickel ABC transporter, permease subunit NikB; This family consists of the NikB family of ...
 12-324 6.66e-36

nickel ABC transporter, permease subunit NikB; This family consists of the NikB family of nickel ABC transporter permeases. Operons that contain this protein also contain a homologous permease subunit NikC. Nickel is used in cells as part of urease or certain hydrogenases or superoxide dismutases. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 131836 [Multi-domain]  Cd Length: 314  Bit Score: 131.81  E-value: 6.66e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013   12 LSYIIALLAIFALNFILPRMMPGNPLQAiYGDEALVAMTPQMEVHLTELFALDKSWSEQMVAYVLALLQGNLGFSYYYKD 91
Cdd:TIGR02789  10 LLLIPVVLAASLLAFILIHLGPSDPAED-YLRLSHIPPTDEAIADMRHSLGLDQPLYVQYFHWLWNALHLDFGISYISDR 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013   92 EVSSVIMGALPWTLLLVGLSLLIATVVGVMLGIESGYRRGERIDRGLLAGLMLLGGLPDFFLGIVLLLIFGVSLNLFPLS 171
Cdd:TIGR02789  89 PVLDEIARSLPATLELAGFALVIVVLVSVPLGILAARYRDRLPDHAVRFIIFLGVSIPNFWLAFLLVWGFSVYLNLLPTN 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013  172 GALTpysglegfplvadiARHLALPLAALVLVDLGGIYLLTRNTVVTILKEGFMLTARAKGCSEFCLRYSHAGRNALLPV 251
Cdd:TIGR02789 169 GAGT--------------WQHLVLPAVTLALMSVSIYARLLRASMLDNMQERYVTYARVRGIKERWVIRRHILRNAILPM 234

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 503486013  252 TTATGLRIPQLITGALFIEIIFSYPGLGLMLRTALDARDYPLIQGILLLVTVTVLFANLFVDQIYKRLDPRTR 324
Cdd:TIGR02789 235 ITALGMHIGELLGGTFVIENIFSWPGVGRYAISAIFNRDYPVIQCYTLLMGLLFVFCNLIVDLFQALLDPRIR 307
PRK10352 PRK10352
nickel transporter permease NikB; Provisional
 15-324 5.22e-31

nickel transporter permease NikB; Provisional


Pssm-ID: 182400 [Multi-domain]  Cd Length: 314  Bit Score: 118.65  E-value: 5.22e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013  15 IIALLAIFALNFILPRMMPGNPLQAiYGDEALVAMTPQMEVHLTELFALDKSWSEQMVAYVLALLQGNLGFSYYYKDEVS 94
Cdd:PRK10352  13 IPMLLAASVIIFLMLRLGTGDPALD-YLRLSNLPPTPEMLASTRTMLGLDQPLYVQYGTWLWKALHLDFGISFATQRPVL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013  95 SVIMGALPWTLLLVGLSLLIATVVGVMLGIESGYRRGERIDRGLLAGLMLLGGLPDFFLGIVLLLIFGVSLNLFPLSGal 174
Cdd:PRK10352  92 DDLLNFLPATLELAGAALVLILLTSVPLGIWAARHRDRLPDFAVRFIAFLGVSMPNFWLAFLLVMAFSVYLQWLPAMG-- 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013 175 tpYSGLEgfplvadiarHLALPLAALVLVDLGGIYLLTRNTVVTILKEGFMLTARAKGCSEFCLRYSHAGRNALLPVTTA 254
Cdd:PRK10352 170 --YGGWQ----------HIILPAVSIAFMSLAINARLLRASMLEVAGQRHVTWARLRGLSERQVERRHILRNASLPMITA 237

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013 255 TGLRIPQLITGALFIEIIFSYPGLGLMLRTALDARDYPLIQGILLLVTVTVLFANLFVDQIYKRLDPRTR 324
Cdd:PRK10352 238 VGMHIGELIGGTMIIENIFAWPGVGRYAVSAIFNRDYPVIQCFTLMMVVVFVVCNLIVDLLNAALDPRIR 307
oppB PRK09471
oligopeptide ABC transporter permease OppB;
12-325 5.95e-31

oligopeptide ABC transporter permease OppB;


Pssm-ID: 181886 [Multi-domain]  Cd Length: 306  Bit Score: 118.25  E-value: 5.95e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013  12 LSYIIALLAIFALNFILPRMMPGNPLQaiyGDEALvamTPQMEVHLTELFALDKSWSEQMVAYVLALLQGNLGFSYYYKD 91
Cdd:PRK09471  10 LEAIPTLFILITISFFMMRLAPGSPFT---GERTL---PPEVMANIEAKYHLNDPIMTQYFSYLKQLAHGDFGPSFKYKD 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013  92 -EVSSVIMGALPWTLLLVGLSLLIATVVGVMLGIESGYRRGERIDRGLLAGLMLLGGLPDFFLGIVLLLIFGVSLNLFPL 170
Cdd:PRK09471  84 ySVNDLVASSFPVSAKLGAAAFFLAVILGVSAGVIAALKQNTKWDYTVMGFAMTGVVIPSFVVAPLLVLIFAITLHWLPG 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013 171 SG--------ALTPYSGLEgFPLVADIARhlalplaalvlvdlggiylLTRNTVVTILKEGFMLTARAKGCSEFCLRYSH 242
Cdd:PRK09471 164 GGwnggalkfMILPMVALS-LAYIASIAR-------------------ITRGSMIEVLHSNFIRTARAKGLPMRRIILRH 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013 243 AGRNALLPVTTATGLRIPQLITGALFIEIIFSYPGLGLMLRTALDARDYPLIQGILLLV-TVTVLFaNLFVDQIYKRLDP 321
Cdd:PRK09471 224 ALKPALLPVLSYMGPAFVGIITGSMVIETIFGLPGIGQLFVNGALNRDYSLVLSLTILVgALTILF-NAIVDVLYAVIDP 302


                 ....
gi 503486013 322 RTRY 325
Cdd:PRK09471 303 KIRY 306
YejB COG4174
ABC-type microcin C transport system, permease component YejB [Secondary metabolites ...
 18-322 2.38e-26

ABC-type microcin C transport system, permease component YejB [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 443333 [Multi-domain]  Cd Length: 363  Bit Score: 107.19  E-value: 2.38e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013  18 LLAIFALNFILPRMMPGNPL-QAI-----------------YGDEALVAMT-------------PQMEVHLTELFALDKS 66
Cdd:COG4174   16 LLGIMLINFVIVQFAPGGPVeQVIaqlqgtgggatgrisggGGDAGGGAAAgggskyrgargldPEFIAELEKQYGFDKP 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013  67 WSEQMVAYVLALLQGNLGFSYYYKDEVSSVIMGALP-------WTLLlvglsllIATVVGVMLGIESGYRRGERIDRGLL 139
Cdd:COG4174   96 AHERFLLMLKNYLRFDFGESYFRDISVIDLILEKLPvsislglWSTL-------LTYLISIPLGIRKAVRDGSRFDVWTS 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013 140 AGLMLLGGLPDFFLGIVLLLIF--GVSLNLFPLSGaLTPySGLEGFPL---VADIARHLALPLAALVLVDLGGIYLLTRN 214
Cdd:COG4174  169 TVIIVGYAIPGFLFAILLIVLFagGSYFDWFPLRG-LTS-DNWDQLSWwgkILDYLWHLTLPVTAMVIGGFATLTLLTKN 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013 215 TVVTILKEGFMLTARAKGCSEFCLRYSHAGRNALLPVTTA-TGLRIPQLITGALFIEIIFSYPGLGLMLRTALDARDYPL 293
Cdd:COG4174  247 SFLDEIRKQYVLTARAKGLSERRVLYGHVFRNAMLIVIAGfPAAFIGAFFTGSLLIETIFSLDGLGLLGFEAVVNRDYPV 326

                        330       340
                 ....*....|....*....|....*....
gi 503486013 294 IQGILLLVTVTVLFANLFVDQIYKRLDPR 322
Cdd:COG4174  327 VFGTLYIFTLIGLVLKLISDLTYVLVDPR 355
PRK15133 PRK15133
microcin C ABC transporter permease YejB; Provisional
 15-322 4.81e-25

microcin C ABC transporter permease YejB; Provisional


Pssm-ID: 185087 [Multi-domain]  Cd Length: 364  Bit Score: 103.29  E-value: 4.81e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013  15 IIALLAIFALNFILPRMMPGNPL-QAIY-------------GDEALVA--------------------MTPQMEVHLTEL 60
Cdd:PRK15133  13 IPTLWAIITINFFIVQIAPGGPVdQAIAaiefgqagglpgaGGEGVRAshaqtgvgnisdsnyrggrgLDPEVIAEITHR 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013  61 FALDKSWSEQMVAYVLALLQGNLGFSYYYKDEVSSVIMGALPWTLLLVGLSLLIATVVGVMLGIESGYRRGERIDRGLLA 140
Cdd:PRK15133  93 YGFDKPLHERYFKMLWDYIRFDFGDSLFRSASVLTLIKDSLPVSITLGLWSTLIIYLVSIPLGIRKAVRNGSRFDVWSSA 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013 141 GLMLLGGLPDFFLGIVLLLIF--GVSLNLFPLSGALTP-YSGLEGFPLVADIARHLALPLAALVLVDLGGIYLLTRNTVV 217
Cdd:PRK15133 173 FIIIGYAIPAFLFAILLIVFFagGSYFDLFPLRGLVSAnFDSLPWYQKITDYLWHITLPVLATVIGGFAALTMLTKNSFL 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013 218 TILKEGFMLTARAKGCSEFCLRYSHAGRNALLPVTTA-TGLRIPQLITGALFIEIIFSYPGLGLMLRTALDARDYPLIQG 296
Cdd:PRK15133 253 DEIRKQYVVTARAKGVSEKNILWKHVFRNAMLLVIAGfPATFISMFFTGSLLIEVMFSLNGLGLLGYEATVSRDYPVMFG 332

                        330       340
                 ....*....|....*....|....*.
gi 503486013 297 ILLLVTVTVLFANLFVDQIYKRLDPR 322
Cdd:PRK15133 333 TLYIFTLIGLLLNIVSDISYTLVDPR 358
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 119-325 2.11e-18

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 81.58  E-value: 2.11e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013  119 GVMLGIESGYRRGERIDRGLLAGLMLLGGLPDFFLGIVLLLIFGVSLNLFPLSGALTPYSGLEGFPLvadiarhlalpla 198
Cdd:pfam00528   1 GIPLGIIAALRRGRRLDRLLRPLIDLLQALPSFVLAILLVVIAILSILGHGILPAIILALLGWAGYA------------- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013  199 alvlvdlggiyLLTRNTVVTILKEGFMLTARAKGCSEFCLRYSHAGRNALLPVTTATGLRIPQLITGALFIEIIFSYPGL 278
Cdd:pfam00528  68 -----------RLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGL 136

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 503486013  279 GLMLRTALDARDYPLIQGILLLVTVTVLFANLFVDQIYKRLDPRTRY 325
Cdd:pfam00528 137 GLLLIEAILGYDYPEIQGPVLAAALILLLLNLLVDILQRLLDPRVRK 183
PRK15110 PRK15110
peptide ABC transporter permease SapB;
74-313 6.12e-15

peptide ABC transporter permease SapB;


Pssm-ID: 185065 [Multi-domain]  Cd Length: 321  Bit Score: 74.34  E-value: 6.12e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013  74 YVLALLQGNLGFSYYYKDEVSSVIMGALPWTLLLVGLSLLIATVVGVMLGIESGYRRGERIDRGLLAGLMLLGGLPDFFL 153
Cdd:PRK15110  47 WFNGLLHWDFGVSSINGQPISEQLKEVFPATMELCILAFGFALLVGIPVGIIAGVTRHKWQDNLISALALLGFSIPVFWL 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013 154 GIVLLLIFGVSLNLFPLSGA---LTPYSGLEGFPLV--------------ADIARHLALPLAALVLVDLGGIYLLTRNTV 216
Cdd:PRK15110 127 ALLLTLFFSLTLGWLPVSGRfdlLYEVKPVTGFALIdawlsdspwrdemiMSAIRHMILPVITLAVAPTTEVIRLMRIST 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013 217 VTILKEGFMLTARAKGCSEFCLRYSHAGRNALLPVTTATGLRIPQLITGALFIEIIFSYPGLGLMLRTALDARDYPLIQG 296
Cdd:PRK15110 207 IEVYDQNYVKAAATRGLSRFTILRRHVLHNALPPVIPRLGLQFSTMLTLAMITEMVFSWPGLGRWLINAIRQQDYAAISA 286

                        250
                 ....*....|....*..
gi 503486013 297 ILLLVTVTVLFANLFVD 313
Cdd:PRK15110 287 GVMVVGSLVIIVNVLSD 303
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 101-310 6.15e-05

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 43.04  E-value: 6.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013 101 LPWTLLLVGLSLLIATVVGVMLGIESGYRRGeRIDRGLLAGLMLLGGLPDFFLGIVLLLIFGVSLNLfplsgaltpysgl 180
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRG-KLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGW------------- 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013 181 egfplvaDIARHLALPLAALVLVDLGGIYLLTRNTVVTILKEGFMLTARAKGCSEFCLRYSHAGRNALLPVTTATGLRIP 260
Cdd:cd06261   67 -------GILPGLGLPALILALLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFA 139

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 503486013 261 QLITGALFIEIIFSYPGLGL-MLRTALDARDYPLIQGILLLVTVTVLFANL 310
Cdd:cd06261  140 RALGEFALVSFLGGGEAPGPgTGLLLIFAILFPGDLGVAAAVALILLLLSL 190
PRK09881 PRK09881
D,D-dipeptide ABC transporter permease;
211-324 5.13e-03

D,D-dipeptide ABC transporter permease;


Pssm-ID: 182131 [Multi-domain]  Cd Length: 296  Bit Score: 38.26  E-value: 5.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486013 211 LTRNTVVTILKEGFMLTARAKGCSEFCLRYSHAGRNALLPVTTATGLRIpqliTGALFIEIIFSYPGLGLMLRTA----- 285
Cdd:PRK09881 174 LARGQALVVRQYTYVQAAKTFGASRWHLISWHILRNSLPPLIVQASLDI----GSAILMAATLGFIGLGAQQPSAewgam 249

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 503486013 286 -LDARDYPLIQ-------GILLLVTVTVLfaNLFVDQIYKRLDPRTR 324
Cdd:PRK09881 250 vANGRNYVLDQwwycafpGAAILLTAVGF--NLFGDGIRDLLDPKAG 294
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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