NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|503477134|ref|WP_013711795|]
View 

sensor histidine kinase [Carnobacterium sp. 17-4]

Protein Classification

sensor histidine kinase( domain architecture ID 11461692)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to an external signal

CATH:  3.30.565.10
EC:  2.7.13.3
Gene Ontology:  GO:0005524|GO:0004673|GO:0007165|GO:0000155
PubMed:  10637609|10339418
SCOP:  4001957

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LytS COG3275
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
334-578 3.38e-67

Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];


:

Pssm-ID: 442506 [Multi-domain]  Cd Length: 352  Bit Score: 222.05  E-value: 3.38e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134 334 LKMYFTDASKLTFVERQLAEGLATIFSSQIELGEMELQSQLLQDAEIKSLQAQVNPHFFFNTINTISALIRVDSEKAREM 413
Cdd:COG3275  115 LLLLLLLLLLLLLLLLLILILLALLLSLQEEELELEELEKELLEAELKALKAQINPHFLFNTLNSIYSLIREDPEKAREL 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134 414 LLQLSTFFRSNLQGARTNVIPLEKELLQVEAYMKLEQARFPDRYQVEMNIEKGRKNILLPPFVIQILVENAFKHAFKNRK 493
Cdd:COG3275  195 LLKLSDLLRYSLYESDKELVPLEEELEFLENYLELEKLRFGDRLQVEIDIDEELLDLLIPPLLLQPLVENAIKHGISSKE 274

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134 494 VGNLVHVTVNKVDQDILISVQDNGYGIDRDRLKKlgkvsvpseqGTGSALENLNKRLISLFGDRAQLNIKSSE-QGTIVM 572
Cdd:COG3275  275 GGGTISISIEVEGDRLVIEVENNGVGIQPKKKKK----------GSGIGLKNVRERLELLYGDKYSLEIESTDgGGTKVT 344


                 ....*.
gi 503477134 573 CRIPYQ 578
Cdd:COG3275  345 LKIPLK 350
5TM-5TMR_LYT pfam07694
5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors ...
 25-205 1.92e-47

5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors of the LytS-YhcK type).


:

Pssm-ID: 429599  Cd Length: 170  Bit Score: 163.51  E-value: 1.92e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134   25 IPYFKNLL-GNRRKLSTMVQLIIVFGIFAIISNFTGIEIRGNqimidqpfsdlsphsSLANTRVLTIGVAGLIGGPIIGV 103
Cdd:pfam07694   1 IPLFRRLLsKRRLRLKDKVLLGLIFGLFSILGTYTGIEIEPG---------------AIANTRAVGIVLAGLLGGPIVGL 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134  104 SVGIVSGAIRYLQGGMDAYIYVISSILVGLFSGLYGLKSIRKNTYPKVGEGLAIGAAMEALQMVSIIFLSTRFQESIDLV 183
Cdd:pfam07694  66 IAGLIAGLHRYFLGGFTALACGISTILAGLIAGLLHRRLKRRRRLISPLLAFLIGLIAEILQMLLILLLALPFDLALALV 145

                         170       180
                  ....*....|....*....|..
gi 503477134  184 QFIMLPMILTNSIGTGIFLSII 205
Cdd:pfam07694 146 KTIALPMILVNSLGTAIFLSIL 167
GAF_3 pfam13492
GAF domain;
238-364 2.95e-06

GAF domain;


:

Pssm-ID: 433253 [Multi-domain]  Cd Length: 129  Bit Score: 46.59  E-value: 2.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134  238 MSEESCTQAAKIIQklIKVSAVSITNKDSILAHVGAASDHHFPSKKIVTSLSKEVLRTGEIKEAHSYHEIGCVhPDCPLE 317
Cdd:pfam13492   5 ILEALLKLLVRLLG--AERAAVYLLDEDGNKLQVAAGYDGEPDPSESLDADSPLARRALSSGEPISGLGSAGE-DGLPDG 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 503477134  318 AAIVIPLKSKNKTVGTLKMYFTDASKLTFVERQLAEGLATIFSSQIE 364
Cdd:pfam13492  82 PALVVPLVAGRRVIGVLALASSKPRAFDAEDLRLLESLAAQIATAIE 128
 
Name Accession Description Interval E-value
LytS COG3275
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
334-578 3.38e-67

Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];


Pssm-ID: 442506 [Multi-domain]  Cd Length: 352  Bit Score: 222.05  E-value: 3.38e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134 334 LKMYFTDASKLTFVERQLAEGLATIFSSQIELGEMELQSQLLQDAEIKSLQAQVNPHFFFNTINTISALIRVDSEKAREM 413
Cdd:COG3275  115 LLLLLLLLLLLLLLLLLILILLALLLSLQEEELELEELEKELLEAELKALKAQINPHFLFNTLNSIYSLIREDPEKAREL 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134 414 LLQLSTFFRSNLQGARTNVIPLEKELLQVEAYMKLEQARFPDRYQVEMNIEKGRKNILLPPFVIQILVENAFKHAFKNRK 493
Cdd:COG3275  195 LLKLSDLLRYSLYESDKELVPLEEELEFLENYLELEKLRFGDRLQVEIDIDEELLDLLIPPLLLQPLVENAIKHGISSKE 274

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134 494 VGNLVHVTVNKVDQDILISVQDNGYGIDRDRLKKlgkvsvpseqGTGSALENLNKRLISLFGDRAQLNIKSSE-QGTIVM 572
Cdd:COG3275  275 GGGTISISIEVEGDRLVIEVENNGVGIQPKKKKK----------GSGIGLKNVRERLELLYGDKYSLEIESTDgGGTKVT 344


                 ....*.
gi 503477134 573 CRIPYQ 578
Cdd:COG3275  345 LKIPLK 350
5TM-5TMR_LYT pfam07694
5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors ...
 25-205 1.92e-47

5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors of the LytS-YhcK type).


Pssm-ID: 429599  Cd Length: 170  Bit Score: 163.51  E-value: 1.92e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134   25 IPYFKNLL-GNRRKLSTMVQLIIVFGIFAIISNFTGIEIRGNqimidqpfsdlsphsSLANTRVLTIGVAGLIGGPIIGV 103
Cdd:pfam07694   1 IPLFRRLLsKRRLRLKDKVLLGLIFGLFSILGTYTGIEIEPG---------------AIANTRAVGIVLAGLLGGPIVGL 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134  104 SVGIVSGAIRYLQGGMDAYIYVISSILVGLFSGLYGLKSIRKNTYPKVGEGLAIGAAMEALQMVSIIFLSTRFQESIDLV 183
Cdd:pfam07694  66 IAGLIAGLHRYFLGGFTALACGISTILAGLIAGLLHRRLKRRRRLISPLLAFLIGLIAEILQMLLILLLALPFDLALALV 145

                         170       180
                  ....*....|....*....|..
gi 503477134  184 QFIMLPMILTNSIGTGIFLSII 205
Cdd:pfam07694 146 KTIALPMILVNSLGTAIFLSIL 167
HATPase_LytS-like cd16957
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 472-576 3.76e-42

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.


Pssm-ID: 340433 [Multi-domain]  Cd Length: 106  Bit Score: 146.80  E-value: 3.76e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134 472 LPPFVIQILVENAFKHAFKNRKVGNLVHVTVNKVDQDILISVQDNGYGIDRDRLKKLGKVSVPSEQGTGSALENLNKRLI 551
Cdd:cd16957    1 VPPFALQVLVENAIRHAFPKRKENNEVRVVVKKDQHKVHVSVSDNGQGIPEERLDLLGKTTVTSEKGTGTALENLNRRLI 80

                         90       100
                 ....*....|....*....|....*.
gi 503477134 552 SLFGDRAQLNIKSSE-QGTIVMCRIP 576
Cdd:cd16957   81 GLFGSEACLHIESEVhGGTEVWFVIP 106
His_kinase pfam06580
Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. ...
 378-456 2.05e-29

Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence. Members of this family often contain pfam02518 and/or pfam00672.


Pssm-ID: 461952 [Multi-domain]  Cd Length: 79  Bit Score: 110.99  E-value: 2.05e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 503477134  378 AEIKSLQAQVNPHFFFNTINTISALIRVDSEKAREMLLQLSTFFRSNLQGARTnVIPLEKELLQVEAYMKLEQARFPDR 456
Cdd:pfam06580   1 AELKALQAQINPHFLFNTLNSISSLAIEDPEEAAEMILKLSDLLRYSLYEGEE-LVTLEEELEFLENYLEIQKIRFGDR 78
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 477-578 6.29e-09

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 53.81  E-value: 6.29e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134   477 IQILVENAFKHAFKNRKVGNLVHVTVNKVDQDILISVQDNGYGIDRDRLKKL------GKVSVPSEQGTGSALeNLNKRL 550
Cdd:smart00387   6 LRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIfepffrTDKRSRKIGGTGLGL-SIVKKL 84

                           90       100
                   ....*....|....*....|....*....
gi 503477134   551 ISLFGdrAQLNIKSSE-QGTIVMCRIPYQ 578
Cdd:smart00387  85 VELHG--GEISVESEPgGGTTFTITLPLE 111
SpoIIE COG5817
Stage II sporulation protein SpoIIE/SpoIIH (serine phosphatase - sigma-F activation) [Cell ...
 2-219 1.11e-06

Stage II sporulation protein SpoIIE/SpoIIH (serine phosphatase - sigma-F activation) [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444519 [Multi-domain]  Cd Length: 803  Bit Score: 51.81  E-value: 1.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134   2 FNLFILMLErGGLIIILAYILMnipYFKNLLGNRRKLST-----MVQLIIVFGIfaIISNFTGIEIrgnqimidqpfSDL 76
Cdd:COG5817  148 YDLLMALFE-AILAFVLTYIFL---QALPLLTEKRKRKSltneeIICLLILLAS--VLTGLGGLTI-----------GGL 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134  77 SPHSSLAntrVLTIGVAGLIGGPIIGVSVGIVSGAIRYLqggmdAYIYVISSILVGLFSGLYG--LKSIRKntyPKVGEG 154
Cdd:COG5817  211 SLKNILS---RLLVLLAAYIGGAGLGAAVGVVIGLILSL-----SNGSSPYMIGLYAFAGLLAglFREFGK---LGVALG 279

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 503477134 155 LAIGAAMEALQMVSIIFLSTRFQES-IDLVQFIMLPMILTNSIgTGIFLSIIDSTLRQEEQTRAVQ 219
Cdd:COG5817  280 FLLGNLLLTLYVSGSGELLLSLYEIaIASLLFLLLPKKLLDKL-SRYLPGTSEHSEEQQQYLERIR 344
GAF_3 pfam13492
GAF domain;
238-364 2.95e-06

GAF domain;


Pssm-ID: 433253 [Multi-domain]  Cd Length: 129  Bit Score: 46.59  E-value: 2.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134  238 MSEESCTQAAKIIQklIKVSAVSITNKDSILAHVGAASDHHFPSKKIVTSLSKEVLRTGEIKEAHSYHEIGCVhPDCPLE 317
Cdd:pfam13492   5 ILEALLKLLVRLLG--AERAAVYLLDEDGNKLQVAAGYDGEPDPSESLDADSPLARRALSSGEPISGLGSAGE-DGLPDG 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 503477134  318 AAIVIPLKSKNKTVGTLKMYFTDASKLTFVERQLAEGLATIFSSQIE 364
Cdd:pfam13492  82 PALVVPLVAGRRVIGVLALASSKPRAFDAEDLRLLESLAAQIATAIE 128
GAF smart00065
Domain present in phytochromes and cGMP-specific phosphodiesterases; Mutations within these ...
 240-373 1.24e-04

Domain present in phytochromes and cGMP-specific phosphodiesterases; Mutations within these domains in PDE6B result in autosomal recessive inheritance of retinitis pigmentosa.


Pssm-ID: 214500 [Multi-domain]  Cd Length: 149  Bit Score: 42.37  E-value: 1.24e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134   240 EESCTQAAKIIQKLIKVSAVSIT--NKDSILAHVGAASDHHFPSKKIVTS-----LSKEVLRTGE--IKEAHSYHEIGCV 310
Cdd:smart00065   3 EELLQTILEELRQLLGADRVLIYlvDENDRGELVLVAADGLTLPTLGIRFpldegLAGRVAETGRplNIPDVEADPLFAE 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 503477134   311 HPDCPLE---AAIVIPLKSKNKTVGTLKMY-FTDASKLTFVERQLAEGLATIFSSQIELGEMELQSQ 373
Cdd:smart00065  83 DLLGRYQgvrSFLAVPLVADGELVGVLALHnKKSPRPFTEEDEELLQALANQLAIALANAQLYEELR 149
 
Name Accession Description Interval E-value
LytS COG3275
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
334-578 3.38e-67

Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];


Pssm-ID: 442506 [Multi-domain]  Cd Length: 352  Bit Score: 222.05  E-value: 3.38e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134 334 LKMYFTDASKLTFVERQLAEGLATIFSSQIELGEMELQSQLLQDAEIKSLQAQVNPHFFFNTINTISALIRVDSEKAREM 413
Cdd:COG3275  115 LLLLLLLLLLLLLLLLLILILLALLLSLQEEELELEELEKELLEAELKALKAQINPHFLFNTLNSIYSLIREDPEKAREL 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134 414 LLQLSTFFRSNLQGARTNVIPLEKELLQVEAYMKLEQARFPDRYQVEMNIEKGRKNILLPPFVIQILVENAFKHAFKNRK 493
Cdd:COG3275  195 LLKLSDLLRYSLYESDKELVPLEEELEFLENYLELEKLRFGDRLQVEIDIDEELLDLLIPPLLLQPLVENAIKHGISSKE 274

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134 494 VGNLVHVTVNKVDQDILISVQDNGYGIDRDRLKKlgkvsvpseqGTGSALENLNKRLISLFGDRAQLNIKSSE-QGTIVM 572
Cdd:COG3275  275 GGGTISISIEVEGDRLVIEVENNGVGIQPKKKKK----------GSGIGLKNVRERLELLYGDKYSLEIESTDgGGTKVT 344


                 ....*.
gi 503477134 573 CRIPYQ 578
Cdd:COG3275  345 LKIPLK 350
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
367-579 2.35e-56

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 196.01  E-value: 2.35e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134 367 EMELQSQLLQDAEIKSLQAQVNPHFFFNTINTISALIRV-DSEKAREMLLQLSTFFRSNLQGARtNVIPLEKELLQVEAY 445
Cdd:COG2972  231 EVYELELEKKEAELKALQAQINPHFLFNTLNSIRWLAELeDPEEAEEMLEALSKLLRYSLSKGD-ELVTLEEELELIKSY 309

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134 446 MKLEQARFPDRYQVEMNIEKGRKNILLPPFVIQILVENAFKHAFKNRKVGNLVHVTVNKVDQDILISVQDNGYGIDRDRL 525
Cdd:COG2972  310 LEIQKLRFGDRLEVEIEIDEELLDLLIPKLILQPLVENAIEHGIEPKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKL 389

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 503477134 526 KKLGKVSVPSEQGTGSALENLNKRLISLFGDRAQLNIKSSE-QGTIVMCRIPYQG 579
Cdd:COG2972  390 EKLLEELSSKGEGRGIGLRNVRERLKLYYGEEYGLEIESEPgEGTTVTIRIPLEE 444
5TM-5TMR_LYT pfam07694
5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors ...
 25-205 1.92e-47

5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors of the LytS-YhcK type).


Pssm-ID: 429599  Cd Length: 170  Bit Score: 163.51  E-value: 1.92e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134   25 IPYFKNLL-GNRRKLSTMVQLIIVFGIFAIISNFTGIEIRGNqimidqpfsdlsphsSLANTRVLTIGVAGLIGGPIIGV 103
Cdd:pfam07694   1 IPLFRRLLsKRRLRLKDKVLLGLIFGLFSILGTYTGIEIEPG---------------AIANTRAVGIVLAGLLGGPIVGL 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134  104 SVGIVSGAIRYLQGGMDAYIYVISSILVGLFSGLYGLKSIRKNTYPKVGEGLAIGAAMEALQMVSIIFLSTRFQESIDLV 183
Cdd:pfam07694  66 IAGLIAGLHRYFLGGFTALACGISTILAGLIAGLLHRRLKRRRRLISPLLAFLIGLIAEILQMLLILLLALPFDLALALV 145

                         170       180
                  ....*....|....*....|..
gi 503477134  184 QFIMLPMILTNSIGTGIFLSII 205
Cdd:pfam07694 146 KTIALPMILVNSLGTAIFLSIL 167
HATPase_LytS-like cd16957
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 472-576 3.76e-42

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.


Pssm-ID: 340433 [Multi-domain]  Cd Length: 106  Bit Score: 146.80  E-value: 3.76e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134 472 LPPFVIQILVENAFKHAFKNRKVGNLVHVTVNKVDQDILISVQDNGYGIDRDRLKKLGKVSVPSEQGTGSALENLNKRLI 551
Cdd:cd16957    1 VPPFALQVLVENAIRHAFPKRKENNEVRVVVKKDQHKVHVSVSDNGQGIPEERLDLLGKTTVTSEKGTGTALENLNRRLI 80

                         90       100
                 ....*....|....*....|....*.
gi 503477134 552 SLFGDRAQLNIKSSE-QGTIVMCRIP 576
Cdd:cd16957   81 GLFGSEACLHIESEVhGGTEVWFVIP 106
His_kinase pfam06580
Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. ...
 378-456 2.05e-29

Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence. Members of this family often contain pfam02518 and/or pfam00672.


Pssm-ID: 461952 [Multi-domain]  Cd Length: 79  Bit Score: 110.99  E-value: 2.05e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 503477134  378 AEIKSLQAQVNPHFFFNTINTISALIRVDSEKAREMLLQLSTFFRSNLQGARTnVIPLEKELLQVEAYMKLEQARFPDR 456
Cdd:pfam06580   1 AELKALQAQINPHFLFNTLNSISSLAIEDPEEAAEMILKLSDLLRYSLYEGEE-LVTLEEELEFLENYLEIQKIRFGDR 78
HATPase_YpdA-YehU-LytS-like cd16924
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 472-576 2.41e-23

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340401 [Multi-domain]  Cd Length: 103  Bit Score: 94.82  E-value: 2.41e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134 472 LPPFVIQILVENAFKHAFKNRKVGNLVHVTVNKVDQDILISVQDNGYGIDRDRLKKLGKvsvPSEQGTGSALENLNKRLI 551
Cdd:cd16924    1 IPPFTLQPLVENAIQHGLSPLTDKGVVTISALKEDNHVMIEVEDNGRGIDPKVLNILGK---KPKEGNGIGLYNVHQRLI 77

                         90       100
                 ....*....|....*....|....*.
gi 503477134 552 SLFGDRAQLNIKSSEQ-GTIVMCRIP 576
Cdd:cd16924   78 LLFGEDYGIHIASEPDkGTRITFTIP 103
HATPase_YehU-like cd16956
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 472-576 4.89e-17

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.


Pssm-ID: 340432 [Multi-domain]  Cd Length: 101  Bit Score: 76.71  E-value: 4.89e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134 472 LPPFVIQILVENAFKHAFKNRKVGNLVHVTVNKVDQDILISVQDNGYGIDRDRLKKLGkvsVPSEQGTGsaLENLNKRLI 551
Cdd:cd16956    1 LPFLTLQPIVENAVKHGLSGLLDGGRVEITARLDGQHLLLEVEDNGGGMDPDTLARIL---IRSSNGLG--LNLVDKRLR 75

                         90       100
                 ....*....|....*....|....*.
gi 503477134 552 SLFGDRAQLNIKSS-EQGTIVMCRIP 576
Cdd:cd16956   76 QAFGNDYGLDIECApGEGTRITIRLP 101
HATPase_YpdA-like cd16955
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 472-576 3.34e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340431 [Multi-domain]  Cd Length: 102  Bit Score: 62.86  E-value: 3.34e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134 472 LPPFVIQILVENAFKHAFKNRKVGNLVHVTVNK-VDQDILISVQDNGYGIDRdrlKKLGKVSVPSEQGTGSALENLNKRL 550
Cdd:cd16955    1 IPKLMIQPLVENAIVHGIQEKKGKGVVKISVKKqLKNRLHIAVEDNGIGISP---KVIERVEQDEMPGNKIGLLNVHQRL 77

                         90       100
                 ....*....|....*....|....*..
gi 503477134 551 ISLFGdrAQLNIKS-SEQGTIVMCRIP 576
Cdd:cd16955   78 KLGYG--EGLHIRSrPDPGTLIAFYIP 102
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 477-578 6.29e-09

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 53.81  E-value: 6.29e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134   477 IQILVENAFKHAFKNRKVGNLVHVTVNKVDQDILISVQDNGYGIDRDRLKKL------GKVSVPSEQGTGSALeNLNKRL 550
Cdd:smart00387   6 LRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIfepffrTDKRSRKIGGTGLGL-SIVKKL 84

                           90       100
                   ....*....|....*....|....*....
gi 503477134   551 ISLFGdrAQLNIKSSE-QGTIVMCRIPYQ 578
Cdd:smart00387  85 VELHG--GEISVESEPgGGTTFTITLPLE 111
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 476-576 1.52e-08

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 52.76  E-value: 1.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134  476 VIQILVENAFKHAFKNRKVgnlvHVTVNKvDQDILISVQDNGYGIDRDRLKKLGK----VSVPSEQGTGSALENLnKRLI 551
Cdd:pfam02518   9 VLSNLLDNALKHAAKAGEI----TVTLSE-GGELTLTVEDNGIGIPPEDLPRIFEpfstADKRGGGGTGLGLSIV-RKLV 82

                          90       100
                  ....*....|....*....|....*
gi 503477134  552 SLFGDRAQLnIKSSEQGTIVMCRIP 576
Cdd:pfam02518  83 ELLGGTITV-ESEPGGGTTVTLTLP 106
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 394-576 2.87e-07

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 53.37  E-value: 2.87e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134 394 NTINTISALIR-----VDSEKAREMLLQ-------LSTFFRSNLQGARTNVIPLeKELLQVEAYMkLEQARFPDRYQVEM 461
Cdd:COG3920  308 NNLQVVSSLLRlqarrADDPEAREALEEsqnriqaLALVHELLYQSEDWEGVDL-RDYLRELLEP-LRDSYGGRGIRIEL 385

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134 462 NIEkgrkNILLPP-------FVIQILVENAFKHAFKNRKVGNlVHVTVNKVDQDILISVQDNGYGIDRDrlkklgkVSVP 534
Cdd:COG3920  386 DGP----DVELPAdaavplgLILNELVTNALKHAFLSGEGGR-IRVSWRREDGRLRLTVSDNGVGLPED-------VDPP 453

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 503477134 535 SEQGTGSAL-ENLNKRLislfgdRAQLNIKSSEqGTIVMCRIP 576
Cdd:COG3920  454 ARKGLGLRLiRALVRQL------GGTLELDRPE-GTRVRITFP 489
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
403-576 4.50e-07

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 51.06  E-value: 4.50e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134 403 IRVDSEKAREMLLQLSTFFRSNLQGARTNVIPLE-KELLQvEAYMKLEQARFPDRYQVEMNIEKGRKNILLPPF----VI 477
Cdd:COG2205   59 IRESAERLLRLIEDLLDLSRLESGKLSLELEPVDlAELLE-EAVEELRPLAEEKGIRLELDLPPELPLVYADPElleqVL 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134 478 QILVENAFKHAFKNRKVgnlvHVTVNKVDQDILISVQDNGYGIDRDRLKKLGK-----VSVPSEQGTGSALeNLNKRLIS 552
Cdd:COG2205  138 ANLLDNAIKYSPPGGTI----TISARREGDGVRISVSDNGPGIPEEELERIFErfyrgDNSRGEGGTGLGL-AIVKRIVE 212

                        170       180
                 ....*....|....*....|....*
gi 503477134 553 LFGdrAQLNIKSSE-QGTIVMCRIP 576
Cdd:COG2205  213 AHG--GTIWVESEPgGGTTFTVTLP 235
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
401-576 7.31e-07

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 51.45  E-value: 7.31e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134 401 ALIRVDSEKAREMLLQLSTFFRSNLQGARTNVIPLE-KELLQ--VEAYMKLEQARfpdRYQVEMNIEKGRKNILLPP--- 474
Cdd:COG0642  148 ETILRSADRLLRLINDLLDLSRLEAGKLELEPEPVDlAELLEevVELFRPLAEEK---GIELELDLPDDLPTVRGDPdrl 224

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134 475 -FVIQILVENAFKHAfknrKVGNLVHVTVNKVDQDILISVQDNGYGIDRDRLKKLGKvsvPSEQGTGSALEN-------L 546
Cdd:COG0642  225 rQVLLNLLSNAIKYT----PEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFE---PFFRTDPSRRGGgtglglaI 297

                        170       180       190
                 ....*....|....*....|....*....|.
gi 503477134 547 NKRLISLFGdrAQLNIKSSE-QGTIVMCRIP 576
Cdd:COG0642  298 VKRIVELHG--GTIEVESEPgKGTTFTVTLP 326
SpoIIE COG5817
Stage II sporulation protein SpoIIE/SpoIIH (serine phosphatase - sigma-F activation) [Cell ...
 2-219 1.11e-06

Stage II sporulation protein SpoIIE/SpoIIH (serine phosphatase - sigma-F activation) [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444519 [Multi-domain]  Cd Length: 803  Bit Score: 51.81  E-value: 1.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134   2 FNLFILMLErGGLIIILAYILMnipYFKNLLGNRRKLST-----MVQLIIVFGIfaIISNFTGIEIrgnqimidqpfSDL 76
Cdd:COG5817  148 YDLLMALFE-AILAFVLTYIFL---QALPLLTEKRKRKSltneeIICLLILLAS--VLTGLGGLTI-----------GGL 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134  77 SPHSSLAntrVLTIGVAGLIGGPIIGVSVGIVSGAIRYLqggmdAYIYVISSILVGLFSGLYG--LKSIRKntyPKVGEG 154
Cdd:COG5817  211 SLKNILS---RLLVLLAAYIGGAGLGAAVGVVIGLILSL-----SNGSSPYMIGLYAFAGLLAglFREFGK---LGVALG 279

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 503477134 155 LAIGAAMEALQMVSIIFLSTRFQES-IDLVQFIMLPMILTNSIgTGIFLSIIDSTLRQEEQTRAVQ 219
Cdd:COG5817  280 FLLGNLLLTLYVSGSGELLLSLYEIaIASLLFLLLPKKLLDKL-SRYLPGTSEHSEEQQQYLERIR 344
GAF_3 pfam13492
GAF domain;
238-364 2.95e-06

GAF domain;


Pssm-ID: 433253 [Multi-domain]  Cd Length: 129  Bit Score: 46.59  E-value: 2.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134  238 MSEESCTQAAKIIQklIKVSAVSITNKDSILAHVGAASDHHFPSKKIVTSLSKEVLRTGEIKEAHSYHEIGCVhPDCPLE 317
Cdd:pfam13492   5 ILEALLKLLVRLLG--AERAAVYLLDEDGNKLQVAAGYDGEPDPSESLDADSPLARRALSSGEPISGLGSAGE-DGLPDG 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 503477134  318 AAIVIPLKSKNKTVGTLKMYFTDASKLTFVERQLAEGLATIFSSQIE 364
Cdd:pfam13492  82 PALVVPLVAGRRVIGVLALASSKPRAFDAEDLRLLESLAAQIATAIE 128
HATPase_EL346-LOV-HK-like cd16951
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 476-576 2.98e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.


Pssm-ID: 340427 [Multi-domain]  Cd Length: 131  Bit Score: 46.64  E-value: 2.98e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134 476 VIQILVENAFKHAFKNRKVGNlVHVTVNKVDQDILISVQDNGYGIDRDrlkklgkvSVPSEQGtgsaleNLNKRLI-SLF 554
Cdd:cd16951   43 VVNELLQNALKHAFSDREGGT-ITIRSVVDGDYLRITVIDDGVGLPQD--------EDWPNKG------SLGLQIVrSLV 107

                         90       100
                 ....*....|....*....|....
gi 503477134 555 GD--RAQLNIKSSEQGTIVMCRIP 576
Cdd:cd16951  108 EGelKAFLEVQSAENGTRVNIDIP 131
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 283-579 4.30e-06

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 49.08  E-value: 4.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134 283 KIVTSLSKEVLRTGEIKEAHSYHEIGCVhpdcpleaAIVIPLKSKNKTVGTLkmyftdaskLTFVERQlaeglatifssq 362
Cdd:COG3290  124 RPIDEVLAEVLETGERDEEILLNGRVLV--------VNRVPIRDDGRVVGAV---------ATFRDRT------------ 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134 363 ielgEMELQSQLLQDAE--IKSLQAQVnpHFFFNTINTISALIRV-DSEKAREMLLQLStffRSNLQGARTNVIPLEKEL 439
Cdd:COG3290  175 ----ELERLEEELEGVKelAEALRAQR--HDFRNHLHTISGLLQLgEYDEALEYIDEIS---EELQELIDSLLSRIGNPV 245

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134 440 LQVEAYMKLEQARfpDRY-QVEMNIEKGRKNILLPPF----VIQILVENAFKHAFKNRKVGNLVHVTVNKVDQDILISVQ 514
Cdd:COG3290  246 LAALLLGKAARAR--ERGiDLTIDIDSDLPDLPLSDTdlvtILGNLLDNAIEAVEKLPEEERRVELSIRDDGDELVIEVE 323

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503477134 515 DNGYGIDRDRLKKL--GKVSVPSEQGTGSALENLNKRLISLFGDraqLNIKSSE-QGTIVMCRIPYQG 579
Cdd:COG3290  324 DSGPGIPEELLEKIfeRGFSTKLGEGRGLGLALVKQIVEKYGGT---IEVESEEgEGTVFTVRLPKEG 388
GAF COG2203
GAF domain [Signal transduction mechanisms];
153-417 1.22e-05

GAF domain [Signal transduction mechanisms];


Pssm-ID: 441805 [Multi-domain]  Cd Length: 712  Bit Score: 48.27  E-value: 1.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134 153 EGLAIGAAMEALQMVSIIFLSTRFQESIDLVQFIMLPMILTNSIGTGIFLSIIDSTLRQEEQTRAVQTHDVLQLANETMp 232
Cdd:COG2203  124 ALAARLLDLLLLGLGGRLRGVVLRGLRSAALLLSRVDTDLVGQLAALAGLILDIARLLTQRARLELERLALLNEISQAL- 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134 233 yFRSGMSEESCTQAAKIIQKLIKVSAVSI---TNKDSILAHVGAASDHHFPSKKIV--TSLSKEVLRTGE---IKEAHSY 304
Cdd:COG2203  203 -RSALDLEELLQRILELAGELLGADRGAIllvDEDGGELELVAAPGLPEEELGRLPlgEGLAGRALRTGEpvvVNDASTD 281

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134 305 HEIGCVHPDCPLE----AAIVIPLKSKNKTVGTLKMYFTDASKLTFVERQLAEGLATIFSSQIELGEMELQSQLLQDAEI 380
Cdd:COG2203  282 PRFAPSLRELLLAlgirSLLCVPLLVDGRLIGVLALYSKEPRAFTEEDLELLEALADQAAIAIERARLYEALEAALAALL 361

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 503477134 381 KSLQAQVNPHFFFNTINTISALIRVDSEKAREMLLQL 417
Cdd:COG2203  362 QELALLRLLLDLELTLLRLRQLLLELLLALLLLLSLL 398
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
396-579 1.87e-05

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 46.54  E-value: 1.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134 396 INTISALIRVDSEKAREMLLQLSTFFRSNLQGART---NVIPLEKELLQVEAYMKLEQARFPDRYQVEMNIEKGRKNILL 472
Cdd:COG4585   76 LEAARRLLDADPEAAREELEEIRELAREALAELRRlvrGLRPPALDDLGLAAALEELAERLLRAAGIRVELDVDGDPDRL 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134 473 PP-------FVIQILVENAFKHAfknrkVGNLVHVTVNKVDQDILISVQDNGYGIDRDRLKKlgkvsvpseQGTGsaLEN 545
Cdd:COG4585  156 PPevelalyRIVQEALTNALKHA-----GATRVTVTLEVDDGELTLTVRDDGVGFDPEAAPG---------GGLG--LRG 219

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 503477134 546 LNKRlISLFGdrAQLNIKSSE-QGTIVMCRIPYQG 579
Cdd:COG4585  220 MRER-AEALG--GTLTIGSAPgGGTRVRATLPLAA 251
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 350-528 9.28e-05

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 44.79  E-value: 9.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134 350 QLAEGLA-------TIFSSQIELGEMELQSQLLQDAEIKSLQaqvnphfffntintisaLIRVDSEKAREMLLQLSTFFR 422
Cdd:COG4191  144 ELAAGIAheinnplAAILGNAELLRRRLEDEPDPEELREALE-----------------RILEGAERAAEIVRSLRAFSR 206

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134 423 -SNLQGARTNVIPLekellqVEAYMKLEQARFPD-RYQVEMNIEKGRKNILLPPfvIQI------LVENAFkHAFKNRKV 494
Cdd:COG4191  207 rDEEEREPVDLNEL------IDEALELLRPRLKArGIEVELDLPPDLPPVLGDP--GQLeqvllnLLINAI-DAMEEGEG 277

                        170       180       190
                 ....*....|....*....|....*....|....
gi 503477134 495 GnLVHVTVNKVDQDILISVQDNGYGIDRDRLKKL 528
Cdd:COG4191  278 G-RITISTRREGDYVVISVRDNGPGIPPEVLERI 310
GAF smart00065
Domain present in phytochromes and cGMP-specific phosphodiesterases; Mutations within these ...
 240-373 1.24e-04

Domain present in phytochromes and cGMP-specific phosphodiesterases; Mutations within these domains in PDE6B result in autosomal recessive inheritance of retinitis pigmentosa.


Pssm-ID: 214500 [Multi-domain]  Cd Length: 149  Bit Score: 42.37  E-value: 1.24e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134   240 EESCTQAAKIIQKLIKVSAVSIT--NKDSILAHVGAASDHHFPSKKIVTS-----LSKEVLRTGE--IKEAHSYHEIGCV 310
Cdd:smart00065   3 EELLQTILEELRQLLGADRVLIYlvDENDRGELVLVAADGLTLPTLGIRFpldegLAGRVAETGRplNIPDVEADPLFAE 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 503477134   311 HPDCPLE---AAIVIPLKSKNKTVGTLKMY-FTDASKLTFVERQLAEGLATIFSSQIELGEMELQSQ 373
Cdd:smart00065  83 DLLGRYQgvrSFLAVPLVADGELVGVLALHnKKSPRPFTEEDEELLQALANQLAIALANAQLYEELR 149
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 423-577 1.89e-04

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 44.20  E-value: 1.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134 423 SNLQGARTNVIPLEKE---LLQVEAYMKLEQARFpdRYQVEMNIEKGRKNILLppfviQILVeNAFKHAFKNRKVGNLVH 499
Cdd:COG5809  331 QAIKYEPKDLNTLIEEvipLLQPQALLKNVQIEL--ELEDDIPDILGDENQLK-----QVFI-NLLKNAIEAMPEGGNIT 402

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134 500 VTVNKVDQD-ILISVQDNGYGIDRDRLKKLGkvsVP----SEQGTGSALEnLNKRLISLFGdrAQLNIKSSEQ-GTIVMC 573
Cdd:COG5809  403 IETKAEDDDkVVISVTDEGCGIPEERLKKLG---EPfyttKEKGTGLGLM-VSYKIIEEHG--GKITVESEVGkGTTFSI 476


                 ....
gi 503477134 574 RIPY 577
Cdd:COG5809  477 TLPI 480
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
476-528 4.39e-04

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 43.00  E-value: 4.39e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 503477134 476 VIQILVENAFKHAFKNRKVgnlvHVTVNKVDQDILISVQDNGYGIDRDRLKKL 528
Cdd:COG5002  285 VLTNLLDNAIKYTPEGGTI----TVSLREEDDQVRISVRDTGIGIPEEDLPRI 333
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 495-576 1.14e-03

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 41.64  E-value: 1.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134 495 GNLVHVTVNKVDQDILISVQDNGYGIDRDRLKKLGkvsVP----SEQGTGSALEnLNKRLISlfGDRAQLNIKSS-EQGT 569
Cdd:COG5805  414 GGTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLG---EPffttKEKGTGLGLM-VSYKIIE--NHNGTIDIDSKvGKGT 487


                 ....*..
gi 503477134 570 IVMCRIP 576
Cdd:COG5805  488 TFTITLP 494
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
480-576 1.30e-03

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 39.13  E-value: 1.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134 480 LVENAFKHAFKNRKVGNlVHVTVNKVDQDILISVQDNGYGIDRDRLKKlgkvSVPSEQGTGSALenlnkRLISLFGDRaq 559
Cdd:COG2172   42 AVTNAVRHAYGGDPDGP-VEVELELDPDGLEIEVRDEGPGFDPEDLPD----PYSTLAEGGRGL-----FLIRRLMDE-- 109

                         90
                 ....*....|....*..
gi 503477134 560 LNIKSSEQGTIVMCRIP 576
Cdd:COG2172  110 VEYESDPGGTTVRLVKR 126
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 476-576 1.42e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 37.92  E-value: 1.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134 476 VIQILVENAFKHAFKNRkvgnlVHVTVNKVDQDILISVQDNGYGIDrdrlkklgkvSVPSEQGTGSALENLNKRLISLfg 555
Cdd:cd16917    4 IVQEALTNALKHAGASR-----VRVTLSYTADELTLTVVDDGVGFD----------GPAPPGGGGFGLLGMRERAELL-- 66

                         90       100
                 ....*....|....*....|..
gi 503477134 556 dRAQLNIKSSE-QGTIVMCRIP 576
Cdd:cd16917   67 -GGTLTIGSRPgGGTRVTARLP 87
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 480-560 2.85e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 37.77  E-value: 2.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503477134 480 LVENAFKHAFKnrkvGNLVHVTVNKVDQDILIsVQDNGYGIDRDRLKKLGK--VSVPSEQGTGSALE-NLNKRLISLFGD 556
Cdd:cd16940   21 LVDNAVRYSPQ----GSRVEIKLSADDGAVIR-VEDNGPGIDEEELEALFErfYRSDGQNYGGSGLGlSIVKRIVELHGG 95


                 ....
gi 503477134 557 RAQL 560
Cdd:cd16940   96 QIFL 99
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 476-525 3.95e-03

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 40.15  E-value: 3.95e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 503477134 476 VIQILVENAFKHAFKNRKVgnLVHVTVNKVDQDILISVQDNGYGID---RDRL 525
Cdd:COG4251  398 VFQNLISNAIKYSRPGEPP--RIEIGAEREGGEWVFSVRDNGIGIDpeyAEKI 448
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH