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Conserved domains on  [gi|503185261|ref|WP_013419922|]
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MULTISPECIES: response regulator transcription factor [Rhodomicrobium]

Protein Classification

response regulator transcription factor( domain architecture ID 11433066)

OmpR family response regulator transcription factor with a signal receiver (REC) domain and a helix-turn-helix (HTH) DNA-binding domain that may be part of a two-component regulatory system

CATH:  3.40.50.2300
Gene Ontology:  GO:0006355|GO:0003677|GO:0000160|GO:0000156
PubMed:  11226872|10966457|31100988
SCOP:  4003632

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 2-206 1.26e-32

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


:

Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 116.98  E-value: 1.26e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503185261   2 IVIVDDRETVLNGYAAWFCREGVSATGLapHDFRQWVNTAPEPDIDAVeafLLgDFQ----NREEVPLKIKSRSGAA-VI 76
Cdd:COG0745    4 ILVVEDDPDIRELLADALEREGYEVDTA--ADGEEALELLEEERPDLI---LL-DLMlpgmDGLEVCRRLRARPSDIpII 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503185261  77 AMNETKSLNDTLDLFAAGVDDVVRKPVHVREILARIRAISRRSQQEaqsqPLSGRIRVFSDGRDPEIDGEPLPLPRRERR 156
Cdd:COG0745   78 MLTARDDEEDRVRGLEAGADDYLTKPFDPEELLARIRALLRRRAAE----VLRVGDLLDLAAREVTRDGEPVELTPKEFR 153

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 503185261 157 ILEYLMTNKGRRVTKSQIFNFVYGlfDDGIDENVIESHISKLRKRLRQRL 206
Cdd:COG0745  154 LLELLMRNPGRVVSREQLLEEVWG--YDYGDDRTVDVHISRLRKKLEDDL 201
 
Name Accession Description Interval E-value
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 2-206 1.26e-32

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 116.98  E-value: 1.26e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503185261   2 IVIVDDRETVLNGYAAWFCREGVSATGLapHDFRQWVNTAPEPDIDAVeafLLgDFQ----NREEVPLKIKSRSGAA-VI 76
Cdd:COG0745    4 ILVVEDDPDIRELLADALEREGYEVDTA--ADGEEALELLEEERPDLI---LL-DLMlpgmDGLEVCRRLRARPSDIpII 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503185261  77 AMNETKSLNDTLDLFAAGVDDVVRKPVHVREILARIRAISRRSQQEaqsqPLSGRIRVFSDGRDPEIDGEPLPLPRRERR 156
Cdd:COG0745   78 MLTARDDEEDRVRGLEAGADDYLTKPFDPEELLARIRALLRRRAAE----VLRVGDLLDLAAREVTRDGEPVELTPKEFR 153

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 503185261 157 ILEYLMTNKGRRVTKSQIFNFVYGlfDDGIDENVIESHISKLRKRLRQRL 206
Cdd:COG0745  154 LLELLMRNPGRVVSREQLLEEVWG--YDYGDDRTVDVHISRLRKKLEDDL 201
trans_reg_C cd00383
DNA-binding effector domain of two-component system response regulators; Bacteria and some ...
 132-221 1.71e-21

DNA-binding effector domain of two-component system response regulators; Bacteria and some eukaryotes use two-component signal transduction systems to detect and respond to changes in the environment. The systems consists of a sensor histidine kinase and a response regulator. The former autophosphorylates a histidine residue on detecting an external stimulus. The phosphate is then transferred to an invariant aspartate residue in a highly conserved receiver domain of the response regulator. Phosphorylation activates a variable effector domain of the response regulator, which triggers the cellular response. This C-terminal effector domain belongs to the winged helix-turn-helix family of transcriptional regulators and contains DNA and RNA polymerase binding sites. Several dimers or monomers bind head to tail to small tandem repeats upstream of the genes. The RNA polymerase binding sites interact with the alpha or sigma subunit of RNA polymerase.


Pssm-ID: 294013 [Multi-domain]  Cd Length: 89  Bit Score: 84.84  E-value: 1.71e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503185261 132 IRVFSDGRDPEIDGEPLPLPRRERRILEYLMTNKGRRVTKSQIFNFVYGlFDDGIDENVIESHISKLRKRLRQRLGSDPI 211
Cdd:cd00383    1 LRLDPARREVTVDGEEVELTPKEFELLELLARNPGRVVSREELLEAVWG-YDYEVDDRTVDVHISRLRKKLEDDPEPRLI 79

                         90
                 ....*....|
gi 503185261 212 DSQRFLGYRL 221
Cdd:cd00383   80 KTVRGVGYRL 89
Trans_reg_C smart00862
Transcriptional regulatory protein, C terminal; This domain is almost always found associated ...
 145-221 5.03e-20

Transcriptional regulatory protein, C terminal; This domain is almost always found associated with the response regulator receiver domain. It may play a role in DNA binding.


Pssm-ID: 214866 [Multi-domain]  Cd Length: 76  Bit Score: 80.67  E-value: 5.03e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 503185261   145 GEPLPLPRRERRILEYLMTNKGRRVTKSQIFNFVYGlFDDGIDENVIESHISKLRKRLRQRLGSDPIDSQRFLGYRL 221
Cdd:smart00862   1 GEPIKLTPKEFRLLELLLRNPGRVVSREELLEAVWG-DDEDVDDNTLDVHISRLRKKLEDDGDPRLIETVRGVGYRL 76
PRK11083 PRK11083
DNA-binding response regulator CreB; Provisional
 94-221 1.11e-18

DNA-binding response regulator CreB; Provisional


Pssm-ID: 236838 [Multi-domain]  Cd Length: 228  Bit Score: 81.16  E-value: 1.11e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503185261  94 GVDDVVRKPVHVREILARIRAISRRSQQEAQSQP--LSGRIRVFSDGRDPEIDGEPLPLPRRERRILEYLMTNKGRRVTK 171
Cdd:PRK11083  97 GADDYVAKPFSPREVAARVRTILRRVKKFAAPSPviRIGHFELDEPAARISYFGTPLTLTRYEFLLLKTLLLSPGRVFSR 176

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 503185261 172 SQIFNFVYGLFDDGIDENViESHISKLRKRLRQ-RLGSDPIDSQRFLGYRL 221
Cdd:PRK11083 177 QQLMDIVWEDAQDSYDRTV-DTHIKTLRAKLRAiNPDLSPINTHRGMGYSL 226
Trans_reg_C pfam00486
Transcriptional regulatory protein, C terminal;
145-221 3.34e-18

Transcriptional regulatory protein, C terminal;


Pssm-ID: 425712 [Multi-domain]  Cd Length: 77  Bit Score: 75.63  E-value: 3.34e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 503185261  145 GEPLPLPRRERRILEYLMTNKGRRVTKSQIFNFVYGlFDDGIDENVIESHISKLRKRLRQRlGSDP--IDSQRFLGYRL 221
Cdd:pfam00486   1 GEEVELTPKEFKLLELLAENPGRVVSREQLLEEVWG-EDYDVDDNTVDVHISRLRKKLEDD-PRDPrlIKTVRGVGYRL 77
 
Name Accession Description Interval E-value
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 2-206 1.26e-32

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 116.98  E-value: 1.26e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503185261   2 IVIVDDRETVLNGYAAWFCREGVSATGLapHDFRQWVNTAPEPDIDAVeafLLgDFQ----NREEVPLKIKSRSGAA-VI 76
Cdd:COG0745    4 ILVVEDDPDIRELLADALEREGYEVDTA--ADGEEALELLEEERPDLI---LL-DLMlpgmDGLEVCRRLRARPSDIpII 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503185261  77 AMNETKSLNDTLDLFAAGVDDVVRKPVHVREILARIRAISRRSQQEaqsqPLSGRIRVFSDGRDPEIDGEPLPLPRRERR 156
Cdd:COG0745   78 MLTARDDEEDRVRGLEAGADDYLTKPFDPEELLARIRALLRRRAAE----VLRVGDLLDLAAREVTRDGEPVELTPKEFR 153

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 503185261 157 ILEYLMTNKGRRVTKSQIFNFVYGlfDDGIDENVIESHISKLRKRLRQRL 206
Cdd:COG0745  154 LLELLMRNPGRVVSREQLLEEVWG--YDYGDDRTVDVHISRLRKKLEDDL 201
trans_reg_C cd00383
DNA-binding effector domain of two-component system response regulators; Bacteria and some ...
 132-221 1.71e-21

DNA-binding effector domain of two-component system response regulators; Bacteria and some eukaryotes use two-component signal transduction systems to detect and respond to changes in the environment. The systems consists of a sensor histidine kinase and a response regulator. The former autophosphorylates a histidine residue on detecting an external stimulus. The phosphate is then transferred to an invariant aspartate residue in a highly conserved receiver domain of the response regulator. Phosphorylation activates a variable effector domain of the response regulator, which triggers the cellular response. This C-terminal effector domain belongs to the winged helix-turn-helix family of transcriptional regulators and contains DNA and RNA polymerase binding sites. Several dimers or monomers bind head to tail to small tandem repeats upstream of the genes. The RNA polymerase binding sites interact with the alpha or sigma subunit of RNA polymerase.


Pssm-ID: 294013 [Multi-domain]  Cd Length: 89  Bit Score: 84.84  E-value: 1.71e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503185261 132 IRVFSDGRDPEIDGEPLPLPRRERRILEYLMTNKGRRVTKSQIFNFVYGlFDDGIDENVIESHISKLRKRLRQRLGSDPI 211
Cdd:cd00383    1 LRLDPARREVTVDGEEVELTPKEFELLELLARNPGRVVSREELLEAVWG-YDYEVDDRTVDVHISRLRKKLEDDPEPRLI 79

                         90
                 ....*....|
gi 503185261 212 DSQRFLGYRL 221
Cdd:cd00383   80 KTVRGVGYRL 89
Trans_reg_C smart00862
Transcriptional regulatory protein, C terminal; This domain is almost always found associated ...
 145-221 5.03e-20

Transcriptional regulatory protein, C terminal; This domain is almost always found associated with the response regulator receiver domain. It may play a role in DNA binding.


Pssm-ID: 214866 [Multi-domain]  Cd Length: 76  Bit Score: 80.67  E-value: 5.03e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 503185261   145 GEPLPLPRRERRILEYLMTNKGRRVTKSQIFNFVYGlFDDGIDENVIESHISKLRKRLRQRLGSDPIDSQRFLGYRL 221
Cdd:smart00862   1 GEPIKLTPKEFRLLELLLRNPGRVVSREELLEAVWG-DDEDVDDNTLDVHISRLRKKLEDDGDPRLIETVRGVGYRL 76
PRK11083 PRK11083
DNA-binding response regulator CreB; Provisional
 94-221 1.11e-18

DNA-binding response regulator CreB; Provisional


Pssm-ID: 236838 [Multi-domain]  Cd Length: 228  Bit Score: 81.16  E-value: 1.11e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503185261  94 GVDDVVRKPVHVREILARIRAISRRSQQEAQSQP--LSGRIRVFSDGRDPEIDGEPLPLPRRERRILEYLMTNKGRRVTK 171
Cdd:PRK11083  97 GADDYVAKPFSPREVAARVRTILRRVKKFAAPSPviRIGHFELDEPAARISYFGTPLTLTRYEFLLLKTLLLSPGRVFSR 176

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 503185261 172 SQIFNFVYGLFDDGIDENViESHISKLRKRLRQ-RLGSDPIDSQRFLGYRL 221
Cdd:PRK11083 177 QQLMDIVWEDAQDSYDRTV-DTHIKTLRAKLRAiNPDLSPINTHRGMGYSL 226
Trans_reg_C pfam00486
Transcriptional regulatory protein, C terminal;
145-221 3.34e-18

Transcriptional regulatory protein, C terminal;


Pssm-ID: 425712 [Multi-domain]  Cd Length: 77  Bit Score: 75.63  E-value: 3.34e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 503185261  145 GEPLPLPRRERRILEYLMTNKGRRVTKSQIFNFVYGlFDDGIDENVIESHISKLRKRLRQRlGSDP--IDSQRFLGYRL 221
Cdd:pfam00486   1 GEEVELTPKEFKLLELLAENPGRVVSREQLLEEVWG-EDYDVDDNTVDVHISRLRKKLEDD-PRDPrlIKTVRGVGYRL 77
PRK10643 PRK10643
two-component system response regulator PmrA;
83-224 3.62e-18

two-component system response regulator PmrA;


Pssm-ID: 182612 [Multi-domain]  Cd Length: 222  Bit Score: 79.69  E-value: 3.62e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503185261  83 SLNDTLDLFAAGVDDVVRKPVHVREILARIRAISRRSQQEAQSQPLSGRIRVFSDGRDPEIDGEPLPLPRRERRILEYLM 162
Cdd:PRK10643  83 TLEDRVAGLDVGADDYLVKPFALEELHARIRALIRRHQGQGENELQVGNLTLNLGRQQVWLDGQELILTPKEFALLSRLM 162

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 503185261 163 TNKGRRVTKSQIFNFVYGlFDDGIDENVIESHIsklrKRLRQRLGSDPIDSQRFLGYRLTQD 224
Cdd:PRK10643 163 LKAGSPVHREILYQDIYN-WDDEPSSNTLEVHI----HNLRDKVGKDRIRTVRGFGYMLVAN 219
PRK15479 PRK15479
transcriptional regulator TctD;
93-221 8.14e-18

transcriptional regulator TctD;


Pssm-ID: 185376 [Multi-domain]  Cd Length: 221  Bit Score: 78.61  E-value: 8.14e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503185261  93 AGVDDVVRKPVHVREILARIRAISRRSQQEAQSQPLSGRIrVFSDGRDPEIDGEPLPLPRRERRILEYLMTNKGRRVTKS 172
Cdd:PRK15479  93 VGADDYLPKPFELEELDARLRALLRRSAGQVQEVQQLGEL-IFHDEGYFLLQGQPLALTPREQALLTVLMYRRTRPVSRQ 171

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 503185261 173 QIFNFVYGLFDDGIDENvIESHISKLRKRLrqrLGSD-PIDSQRFLGYRL 221
Cdd:PRK15479 172 QLFEQVFSLNDEVSPES-IELYIHRLRKKL---QGSDvRITTLRGLGYVL 217
PRK10336 PRK10336
two-component system response regulator QseB;
75-221 9.63e-17

two-component system response regulator QseB;


Pssm-ID: 182387 [Multi-domain]  Cd Length: 219  Bit Score: 75.70  E-value: 9.63e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503185261  75 VIAMNETKSLNDTLDLFAAGVDDVVRKPVHVREILARIRAISRRSQQEAQSQPLSGRIRVFSDGRDPEIDGEPLPLPRRE 154
Cdd:PRK10336  75 VLILTARDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKE 154

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 503185261 155 RRILEYLMTNKGRRVTKSQIFNFVYGlFDDGIDENVIESHISKLRKrlrqRLGSDPIDSQRFLGYRL 221
Cdd:PRK10336 155 FALLELLMRNAGRVLPRKLIEEKLYT-WDEEVTSNAVEVHVHHLRR----KLGSDFIRTVHGIGYTL 216
orf27 CHL00148
Ycf27; Reviewed
 62-219 1.10e-13

Ycf27; Reviewed


Pssm-ID: 214376 [Multi-domain]  Cd Length: 240  Bit Score: 67.82  E-value: 1.10e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503185261  62 EVPLKIKSRSGAAVIAMNETKSLNDTLDLFAAGVDDVVRKPVHVREILARIRAISRRSQQEAQSQPLS-------GRIRV 134
Cdd:CHL00148  67 GVCQEIRKESDVPIIMLTALGDVSDRITGLELGADDYVVKPFSPKELEARIRSVLRRTNKKSFSSKIPnssiiriGFLKI 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503185261 135 FSDGRDPEIDGEPLPLPRRERRILEYLMTNKGRRVTKSQIFNFVYGL-FDDGIDENVIESHISklrkRLRQRLGSDP--- 210
Cdd:CHL00148 147 DLNKKQVYKNNERIRLTGMEFSLLELLISKSGEIFSRATILKEVWGYtPERHIDTRVVDVHIS----RLRAKLEDDPsnp 222

                        170
                 ....*....|.
gi 503185261 211 --IDSQRFLGY 219
Cdd:CHL00148 223 dlILTARGTGY 233
CadC1 COG3710
DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];
130-224 6.75e-12

DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];


Pssm-ID: 442924 [Multi-domain]  Cd Length: 106  Bit Score: 59.92  E-value: 6.75e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503185261 130 GRIRVFSDGRDPEIDGEPLPLPRRERRILEYLMTNKGRRVTKSQIFNFVYGlfDDGIDENVIESHISKLRKRLRqrlgsD 209
Cdd:COG3710    6 GDFRLDPARRELLRDGEPVRLSPRAFDLLLLLLEHPGRVVSRDELLAAVWP--GRVVSDNSLTQAISRLRKALG-----D 78

                         90       100
                 ....*....|....*....|.
gi 503185261 210 PIDSQRFL------GYRLTQD 224
Cdd:COG3710   79 DGLEPRLIrtvprrGYRLVAP 99
PRK10529 PRK10529
DNA-binding transcriptional activator KdpE; Provisional
 71-220 2.24e-11

DNA-binding transcriptional activator KdpE; Provisional


Pssm-ID: 182522 [Multi-domain]  Cd Length: 225  Bit Score: 60.97  E-value: 2.24e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503185261  71 SGAAVIAMNETKSLNDTLDLFAAGVDDVVRKPVHVREILARIRAISRRSQQEAQSQPLSgrirVFSD------GRDPEID 144
Cdd:PRK10529  71 SAIPVIVLSARSEESDKIAALDAGADDYLSKPFGIGELQARLRVALRRHSATPAPDPLV----KFSDvtvdlaARVIHRG 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503185261 145 GEPLPLPRRERRILEYLMTNKGRRVTKSQIFNFVYGlfddgidENVIEsHISKLR---KRLRQRLGSDPIDSQRFL---- 217
Cdd:PRK10529 147 EEEVHLTPIEFRLLAVLLNNAGKVLTQRQLLNQVWG-------PNAVE-HSHYLRiymGHLRQKLEQDPARPRHFItetg 218


                 ....
gi 503185261 218 -GYR 220
Cdd:PRK10529 219 iGYR 222
PRK10816 PRK10816
two-component system response regulator PhoP;
83-220 7.91e-11

two-component system response regulator PhoP;


Pssm-ID: 182755 [Multi-domain]  Cd Length: 223  Bit Score: 59.75  E-value: 7.91e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503185261  83 SLNDTLDLFAAGVDDVVRKPVHVREILARIRAISRRSQQEAqSQPLS-GRIRVFSDGRDPEIDGEPLPLPRRERRILEYL 161
Cdd:PRK10816  83 SWQDKVEVLSAGADDYVTKPFHIEEVMARMQALMRRNSGLA-SQVISlPPFQVDLSRRELSINDEVIKLTAFEYTIMETL 161

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 503185261 162 MTNKGRRVTKSQIFNFVYGlfddgiDENVIESH-----ISKLRKRLRQRLGSDPIDSQRFLGYR 220
Cdd:PRK10816 162 IRNNGKVVSKDSLMLQLYP------DAELRESHtidvlMGRLRKKIQAQYPQEVITTVRGQGYR 219
PRK10955 PRK10955
envelope stress response regulator transcription factor CpxR;
94-210 1.91e-10

envelope stress response regulator transcription factor CpxR;


Pssm-ID: 182864 [Multi-domain]  Cd Length: 232  Bit Score: 58.66  E-value: 1.91e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503185261  94 GVDDVVRKPVHVREILARIRAISRRSQ-QEAQSQPLSGRIRVFSD------GR-DPEIDGEPLPLPRRERRILEYLMTNK 165
Cdd:PRK10955  93 GADDYLPKPFNDRELVARIRAILRRSHwSEQQQNNDNGSPTLEVDalslnpGRqEASFDGQTLELTGTEFTLLYLLAQHL 172

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 503185261 166 GRRVTKSQIFNFVYGL----FDDGIDenvieSHISKLRKRLRQRLGSDP 210
Cdd:PRK10955 173 GQVVSREHLSQEVLGKrltpFDRAID-----MHISNLRRKLPDRKDGHP 216
PRK10161 PRK10161
phosphate response regulator transcription factor PhoB;
75-222 1.05e-09

phosphate response regulator transcription factor PhoB;


Pssm-ID: 182277 [Multi-domain]  Cd Length: 229  Bit Score: 56.65  E-value: 1.05e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503185261  75 VIAMNETKSLNDTLDLFAAGVDDVVRKPVHVREILARIRAISRRSQQEAQSQPLSGRIRVFSDGRDPEIDGE-PLPLPRR 153
Cdd:PRK10161  79 VVMLTARGEEEDRVRGLETGADDYITKPFSPKELVARIKAVMRRISPMAVEEVIEMQGLSLDPTSHRVMAGEePLEMGPT 158

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 503185261 154 ERRILEYLMTNKGRRVTKSQIFNFVYGLfDDGIDENVIESHISKLRKRLRQRLGSDPIDSQRFLGYRLT 222
Cdd:PRK10161 159 EFKLLHFFMTHPERVYSREQLLNHVWGT-NVYVEDRTVDVHIRRLRKALEPGGHDRMVQTVRGTGYRFS 226
PRK10710 PRK10710
DNA-binding transcriptional regulator BaeR; Provisional
 94-220 1.18e-09

DNA-binding transcriptional regulator BaeR; Provisional


Pssm-ID: 182665 [Multi-domain]  Cd Length: 240  Bit Score: 56.62  E-value: 1.18e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503185261  94 GVDDVVRKPVHVREILARIRAISRRSQQEAQSQPLSGRIRVFSDGRDPEI--DGEPLPLPRRERRILEYLMTNKGRRVTK 171
Cdd:PRK10710 103 GADDYICKPYSPREVVARVKTILRRCKPQRELQQQDAESPLIIDESRFQAswRGKMLDLTPAEFRLLKTLSHEPGKVFSR 182

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 503185261 172 SQIFNFVYglfDDG--IDENVIESHISKLRKRLRQRLGSDP-IDSQRFLGYR 220
Cdd:PRK10710 183 EQLLNHLY---DDYrvVTDRTIDSHIKNLRRKLESLDAEQSfIRAVYGVGYR 231
PRK11517 PRK11517
DNA-binding response regulator HprR;
75-224 2.99e-09

DNA-binding response regulator HprR;


Pssm-ID: 183172 [Multi-domain]  Cd Length: 223  Bit Score: 55.29  E-value: 2.99e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503185261  75 VIAMNETKSLNDTLDLFAAGVDDVVRKPVHVREILARIRAISRRSQQEAQSQPLSGrIRVFSDGRDPEIDGEPLPLPRRE 154
Cdd:PRK11517  74 VICLTARDSVDDRVRGLDSGANDYLVKPFSFSELLARVRAQLRQHHALNSTLEISG-LRMDSVSQSVSRDNISITLTRKE 152

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 503185261 155 RRILEYLMTNKGRRVTKSQIFNFVYGL-FDDgiDENVIESHISKLRKRLRQRLGSDPIDSQRFLGYRLTQD 224
Cdd:PRK11517 153 FQLLWLLASRAGEIIPRTVIASEIWGInFDS--DTNTVDVAIRRLRAKVDDPFPEKLIATIRGMGYSFVAV 221
ompR PRK09468
osmolarity response regulator; Provisional
 93-200 1.35e-06

osmolarity response regulator; Provisional


Pssm-ID: 181883 [Multi-domain]  Cd Length: 239  Bit Score: 47.66  E-value: 1.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503185261  93 AGVDDVVRKPVHVREILARIRAISRRSQQEAQSQPLS-------GRIRVFSDGRDPEIDGEPLPLPRRERRILEYLMTNK 165
Cdd:PRK09468  98 IGADDYLPKPFNPRELLARIRAVLRRQAPELPGAPSQeeeviafGKFKLNLGTRELFRGDEPMPLTTGEFAVLKALVSHP 177

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 503185261 166 GRRVTKSQIFNFV----YGLFDDGIDenvieSHISKLRK 200
Cdd:PRK09468 178 REPLSRDKLMNLArgreYSAMERSID-----VQISRLRR 211
PRK09836 PRK09836
DNA-binding transcriptional activator CusR; Provisional
 94-221 9.92e-06

DNA-binding transcriptional activator CusR; Provisional


Pssm-ID: 182102 [Multi-domain]  Cd Length: 227  Bit Score: 44.92  E-value: 9.92e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503185261  94 GVDDVVRKPVHVREILARIRAISRRSQQ---EAQSQPLSGRIRVFSdgRDPEIDGEPLPLPRRERRILEYLMTNKGRRVT 170
Cdd:PRK09836  94 GADDYLVKPFAFAELLARVRTLLRRGAAviiESQFQVADLMVDLVS--RKVTRSGTRITLTSKEFTLLEFFLRHQGEVLP 171

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 503185261 171 KSQIFNFVYGL-FDDgiDENVIESHISKLRKRLRQRLGSDPIDSQRFLGYRL 221
Cdd:PRK09836 172 RSLIASQVWDMnFDS--DTNAIDVAVKRLRGKIDNDFEPKLIQTVRGVGYML 221
REC_OmpR_EcPhoP-like cd19934
phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; ...
 83-119 2.44e-05

phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; Escherichia coli PhoP (EcPhoP) is part of the PhoQ/PhoP two-component system (TCS) that regulates virulence genes and plays an essential role in the response of the bacteria to the environment of their mammalian hosts, sensing several stimuli such as extracellular magnesium limitation, low pH, the presence of cationic antimicrobial peptides, and osmotic upshift. This subfamily also includes Brucella suis FeuP, part of the FeuPQ TCS that is involved in the regulation of iron uptake, and Microchaete diplosiphon RcaC, which is required for chromatic adaptation. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381161 [Multi-domain]  Cd Length: 117  Bit Score: 42.27  E-value: 2.44e-05
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 503185261  83 SLNDTLDLFAAGVDDVVRKPVHVREILARIRAISRRS 119
Cdd:cd19934   81 SWQDKVEGLDAGADDYLTKPFHIEELLARLRALIRRA 117
REC_OmpR_DrrD-like cd17625
phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a ...
 75-118 1.57e-03

phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a OmpR/PhoB homolog from Thermotoga maritima whose function is not yet known. This subfamily also includes Streptococcus agalactiae transcriptional regulatory protein DltR, part of the DltS/DltR two-component system (TCS), and Pseudomonas aeruginosa transcriptional activator protein PfeR, part of the PfeR/PfeS TCS, which activates expression of the ferric enterobactin receptor. The DltS/DltR TCS regulates the expression of the dlt operon, which comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids. Members of this subfamily belong to the OmpR/PhoB family, which comprises of two domains, an N-terminal receiver domain and a C-terminal DNA-binding winged helix-turn-helix effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381140 [Multi-domain]  Cd Length: 115  Bit Score: 37.20  E-value: 1.57e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 503185261  75 VIAMNETKSLNDTLDLFAAGVDDVVRKPVHVREILARIRAISRR 118
Cdd:cd17625   72 VLLLTALDAVEDRVKGLDLGADDYLPKPFSLAELLARIRALLRR 115
REC_OmpR_CpxR cd17623
phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is ...
 94-118 2.46e-03

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381138 [Multi-domain]  Cd Length: 115  Bit Score: 36.51  E-value: 2.46e-03
                         10        20
                 ....*....|....*....|....*
gi 503185261  94 GVDDVVRKPVHVREILARIRAISRR 118
Cdd:cd17623   91 GADDYLPKPFNPRELVARIRAILRR 115
REC_OmpR_YycF-like cd17614
phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF ...
 62-118 4.79e-03

phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF appears to play an important role in cell wall integrity in a wide range of gram-positive bacteria, and may also modulate cell membrane integrity. It functions as part of a phosphotransfer system that ultimately controls the levels of competence within the bacteria. YycF belongs to the OmpR family of response regulators, which are characterized by a REC domain and a winged helix-turn-helix effector domain involved in DNA binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381130 [Multi-domain]  Cd Length: 115  Bit Score: 35.86  E-value: 4.79e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 503185261  62 EVPLKIKSRSGAAVIAMNETKSLNDTLDLFAAGVDDVVRKPVHVREILARIRAISRR 118
Cdd:cd17614   59 EVCREVRKTSNVPIIMLTAKDSEVDKVLGLELGADDYVTKPFSNRELLARVKANLRR 115
REC_OmpR_MtPhoP-like cd17615
phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; ...
 83-119 9.07e-03

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381131 [Multi-domain]  Cd Length: 118  Bit Score: 35.02  E-value: 9.07e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 503185261  83 SLNDTLDLFAAGVDDVVRKPVHVREILARIRAISRRS 119
Cdd:cd17615   82 SVEDRIAGLTAGGDDYVTKPFSLEEVVARLRALLRRS 118
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
 83-117 9.65e-03

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 34.77  E-value: 9.65e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 503185261  83 SLNDTLDLFAAGVDDVVRKPVHVREILARIRAISR 117
Cdd:cd17624   81 GVDDRVAGLDAGADDYLVKPFALEELLARLRALLR 115
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 75-117 9.93e-03

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 35.65  E-value: 9.93e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 503185261  75 VIAMNETKSLNDTLDLFAAGVDDVVRKPVHVREILARIRAISR 117
Cdd:COG3706   78 IIFLTALDDEEDRARALEAGADDYLTKPFDPEELLARVDLVAR 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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