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Conserved domains on  [gi|503144367|ref|WP_013379028|]
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response regulator [Eubacterium callanderi]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
1-110 5.74e-25

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


:

Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 99.12  E-value: 5.74e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   1 MHILATDDEALSLDSLTVTLQKaFPHAE-VHSFQQPRKALDFVrflcqrQNTSLDFAFLDVEMPGMTGIELAAELKKLCP 79
Cdd:COG3279    2 MKILIVDDEPLARERLERLLEK-YPDLEvVGEASNGEEALELL------EEHKPDLVFLDIQMPGLDGFELARQLRELDP 74
                         90       100       110
                 ....*....|....*....|....*....|.
gi 503144367  80 DVGIFFVTGFADYAYEAYRVHARGYILKPVT 110
Cdd:COG3279   75 PPPIIFTTAYDEYALEAFEVNAVDYLLKPID 105
DnrI COG3629
DNA-binding transcriptional regulator DnrI/AfsR/EmbR, SARP family, contains BTAD domain ...
134-240 1.02e-09

DNA-binding transcriptional regulator DnrI/AfsR/EmbR, SARP family, contains BTAD domain [Transcription];


:

Pssm-ID: 442847 [Multi-domain]  Cd Length: 244  Bit Score: 57.54  E-value: 1.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367 134 RVRLRTFGTFDAFMGAKPIAFSRTRAKELLAYLADRQGSGVTLADICSALFEDESgSKTSKKYVQNLISSLKQGLEAVGA 213
Cdd:COG3629    1 PLRFRLLGPLEVRVDGRPVPLGGPKQRALLAYLALRAGRPVSRDRLADLLWGDDP-PASARANLRTYVSRLRRALGPAGG 79
                         90       100
                 ....*....|....*....|....*..
gi 503144367 214 GDILIKKWNYlALDTQKVDCDYYRFLE 240
Cdd:COG3629   80 DLLVTRGGGY-RLDVDPDEVDLHRFER 105
 
Name Accession Description Interval E-value
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
1-110 5.74e-25

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 99.12  E-value: 5.74e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   1 MHILATDDEALSLDSLTVTLQKaFPHAE-VHSFQQPRKALDFVrflcqrQNTSLDFAFLDVEMPGMTGIELAAELKKLCP 79
Cdd:COG3279    2 MKILIVDDEPLARERLERLLEK-YPDLEvVGEASNGEEALELL------EEHKPDLVFLDIQMPGLDGFELARQLRELDP 74
                         90       100       110
                 ....*....|....*....|....*....|.
gi 503144367  80 DVGIFFVTGFADYAYEAYRVHARGYILKPVT 110
Cdd:COG3279   75 PPPIIFTTAYDEYALEAFEVNAVDYLLKPID 105
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
7-122 6.56e-20

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 82.77  E-value: 6.56e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   7 DDEALSLDSLTVTLQKAFPHAE-VHSFQQPRKALDFVrflcqrQNTSLDFAFLDVEMPGMTGIELAAELKKLCPDVGIFF 85
Cdd:cd17536    5 DDEPLIREGLKKLIDWEELGFEvVGEAENGEEALELI------EEHKPDIVITDIRMPGMDGLELIEKIRELYPDIKIII 78
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 503144367  86 VTGFAD--YAYEAYRVHARGYILKPVTGELIEEEMAHLA 122
Cdd:cd17536   79 LSGYDDfeYAQKAIRLGVVDYLLKPVDEEELEEALEKAK 117
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
3-115 2.55e-16

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 72.95  E-value: 2.55e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367    3 ILATDDEALSLDSLTVTLQKAfpHAEVHSFQQPRKALDFVRFLcqrqntSLDFAFLDVEMPGMTGIELAAELKKLCPDVG 82
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKE--GYVVAEADDGKEALELLKEE------RPDLILLDINMPGMDGLELLKRIRRRDPTTP 72
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 503144367   83 IFFVTGFADYAY--EAYRVHARGYILKPVT-GELIE 115
Cdd:pfam00072  73 VIILTAHGDEDDavEALEAGADDFLSKPFDpDELLA 108
DnrI COG3629
DNA-binding transcriptional regulator DnrI/AfsR/EmbR, SARP family, contains BTAD domain ...
134-240 1.02e-09

DNA-binding transcriptional regulator DnrI/AfsR/EmbR, SARP family, contains BTAD domain [Transcription];


Pssm-ID: 442847 [Multi-domain]  Cd Length: 244  Bit Score: 57.54  E-value: 1.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367 134 RVRLRTFGTFDAFMGAKPIAFSRTRAKELLAYLADRQGSGVTLADICSALFEDESgSKTSKKYVQNLISSLKQGLEAVGA 213
Cdd:COG3629    1 PLRFRLLGPLEVRVDGRPVPLGGPKQRALLAYLALRAGRPVSRDRLADLLWGDDP-PASARANLRTYVSRLRRALGPAGG 79
                         90       100
                 ....*....|....*....|....*..
gi 503144367 214 GDILIKKWNYlALDTQKVDCDYYRFLE 240
Cdd:COG3629   80 DLLVTRGGGY-RLDVDPDEVDLHRFER 105
PRK11697 PRK11697
two-component system response regulator BtsR;
54-109 8.85e-09

two-component system response regulator BtsR;


Pssm-ID: 236956 [Multi-domain]  Cd Length: 238  Bit Score: 54.47  E-value: 8.85e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 503144367  54 DFAFLDVEMPGMTGIELAAELKklcPDV--GIFFVTGFADYAYEAYRVHARGYILKPV 109
Cdd:PRK11697  49 DVVFLDIQMPRISGLELVGMLD---PEHmpYIVFVTAFDEYAIKAFEEHAFDYLLKPI 103
Trans_reg_C smart00862
Transcriptional regulatory protein, C terminal; This domain is almost always found associated ...
150-218 3.42e-03

Transcriptional regulatory protein, C terminal; This domain is almost always found associated with the response regulator receiver domain. It may play a role in DNA binding.


Pssm-ID: 214866 [Multi-domain]  Cd Length: 76  Bit Score: 35.61  E-value: 3.42e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 503144367   150 KPIAFSRTRAkELLAYLADRQGSGVTLADICSALFEDESGSktSKKYVQNLISSLKQGLEAVGAGDILI 218
Cdd:smart00862   2 EPIKLTPKEF-RLLELLLRNPGRVVSREELLEAVWGDDEDV--DDNTLDVHISRLRKKLEDDGDPRLIE 67
 
Name Accession Description Interval E-value
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
1-110 5.74e-25

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 99.12  E-value: 5.74e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   1 MHILATDDEALSLDSLTVTLQKaFPHAE-VHSFQQPRKALDFVrflcqrQNTSLDFAFLDVEMPGMTGIELAAELKKLCP 79
Cdd:COG3279    2 MKILIVDDEPLARERLERLLEK-YPDLEvVGEASNGEEALELL------EEHKPDLVFLDIQMPGLDGFELARQLRELDP 74
                         90       100       110
                 ....*....|....*....|....*....|.
gi 503144367  80 DVGIFFVTGFADYAYEAYRVHARGYILKPVT 110
Cdd:COG3279   75 PPPIIFTTAYDEYALEAFEVNAVDYLLKPID 105
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
3-108 2.50e-21

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 85.98  E-value: 2.50e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   3 ILATDDEALSLDSLTVTLQKAFPHAEVHSFQQPRKALDFVRflcqrqNTSLDFAFLDVEMPGMTGIELAAELKKLCPDVG 82
Cdd:COG4753    2 VLIVDDEPLIREGLKRILEWEAGFEVVGEAENGEEALELLE------EHKPDLVITDINMPGMDGLELLEAIRELDPDTK 75
                         90       100
                 ....*....|....*....|....*...
gi 503144367  83 IFFVTGFAD--YAYEAYRVHARGYILKP 108
Cdd:COG4753   76 IIILSGYSDfeYAQEAIKLGADDYLLKP 103
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
7-122 6.56e-20

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 82.77  E-value: 6.56e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   7 DDEALSLDSLTVTLQKAFPHAE-VHSFQQPRKALDFVrflcqrQNTSLDFAFLDVEMPGMTGIELAAELKKLCPDVGIFF 85
Cdd:cd17536    5 DDEPLIREGLKKLIDWEELGFEvVGEAENGEEALELI------EEHKPDIVITDIRMPGMDGLELIEKIRELYPDIKIII 78
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 503144367  86 VTGFAD--YAYEAYRVHARGYILKPVTGELIEEEMAHLA 122
Cdd:cd17536   79 LSGYDDfeYAQKAIRLGVVDYLLKPVDEEELEEALEKAK 117
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
3-124 1.99e-17

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 76.04  E-value: 1.99e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   3 ILATDDEALSLDSLTVTLQKaFPHAE-VHSFQQPRKALDFVrflcQRQNTslDFAFLDVEMPGMTGIELAAELKKLCPDV 81
Cdd:cd17532    1 ALIVDDEPLAREELRYLLEE-HPDIEiVGEAENGEEALEAI----EELKP--DVVFLDIQMPGLDGLELAKKLSKLAKPP 73
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 503144367  82 GIFFVTGFADYAYEAYRVHARGYILKPVTGELIEEEMAHLATT 124
Cdd:cd17532   74 LIVFVTAYDEYAVEAFELNAVDYLLKPFSEERLAEALAKLRKR 116
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
7-108 8.77e-17

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 73.80  E-value: 8.77e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   7 DDEALSLDSLTVTLQKAFphAEVHSFQQPRKALDFVrflcqrQNTSLDFAFLDVEMPGMTGIELAAELKKLCPDVGIFFV 86
Cdd:cd00156    4 DDDPAIRELLKSLLEREG--YEVDTAADGEEALELL------REERPDLVLLDLMMPGMDGLELLRKLRELPPDIPVIVL 75
                         90       100
                 ....*....|....*....|....
gi 503144367  87 TGFADYAY--EAYRVHARGYILKP 108
Cdd:cd00156   76 TAKADEEDavRALELGADDYLVKP 99
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
1-116 1.65e-16

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 74.24  E-value: 1.65e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   1 MHILATDDEALSLDSLTVTLQKAFPHAEVHSFQQPRKALDFVRflcqrqNTSLDFAFLDVEMPGMTGIELAAELKKLCPD 80
Cdd:COG4565    4 IRVLIVEDDPMVAELLRRYLERLPGFEVVGVASSGEEALALLA------EHRPDLILLDIYLPDGDGLELLRELRARGPD 77
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 503144367  81 VGIFFVTGFADYAY--EAYRVHARGYILKPVTGELIEE 116
Cdd:COG4565   78 VDVIVITAARDPETvrEALRAGVVDYLIKPFTFERLRE 115
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
3-115 2.55e-16

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 72.95  E-value: 2.55e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367    3 ILATDDEALSLDSLTVTLQKAfpHAEVHSFQQPRKALDFVRFLcqrqntSLDFAFLDVEMPGMTGIELAAELKKLCPDVG 82
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKE--GYVVAEADDGKEALELLKEE------RPDLILLDINMPGMDGLELLKRIRRRDPTTP 72
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 503144367   83 IFFVTGFADYAY--EAYRVHARGYILKPVT-GELIE 115
Cdd:pfam00072  73 VIILTAHGDEDDavEALEAGADDFLSKPFDpDELLA 108
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
1-121 2.61e-16

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 73.35  E-value: 2.61e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   1 MHILATDDEALSLDSLTVTLQKAfpHAEVHSFQQPRKALDFVRflcqrqNTSLDFAFLDVEMPGMTGIELAAELKKLC-- 78
Cdd:COG0784    6 KRILVVDDNPDNRELLRRLLERL--GYEVTTAEDGAEALELLR------AGPPDLILLDINMPGMDGLELLRRIRALPrl 77
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 503144367  79 PDVGIFFVTGFADYAY--EAYRVHARGYILKPVTGELIEEEMAHL 121
Cdd:COG0784   78 PDIPIIALTAYADEEDreRALEAGADDYLTKPVDPEELLEALRRL 122
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
1-116 2.94e-16

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 77.70  E-value: 2.94e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   1 MHILATDDEALSLDSLTVTLQKAfpHAEVHSFQQPRKALDFVRflcqrqNTSLDFAFLDVEMPGMTGIELAAELKKLCPD 80
Cdd:COG2204    3 ARILVVDDDPDIRRLLKELLERA--GYEVETAASGEEALALLR------EEPPDLVLLDLRMPGMDGLELLRELRALDPD 74
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 503144367  81 VGIFFVTGFAD--YAYEAYRVHARGYILKPVTGELIEE 116
Cdd:COG2204   75 LPVILLTGYGDveTAVEAIKAGAFDYLTKPFDLEELLA 112
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
1-121 2.44e-15

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 72.89  E-value: 2.44e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   1 MHILATDDEALSLDSLTVTLQKAfpHAEVHSFQQPRKALDFVRflcqrqNTSLDFAFLDVEMPGMTGIELAAELKKL--C 78
Cdd:COG3437    7 PTVLIVDDDPENLELLRQLLRTL--GYDVVTAESGEEALELLL------EAPPDLILLDVRMPGMDGFELLRLLRADpsT 78
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 503144367  79 PDVGIFFVTGFAD--YAYEAYRVHARGYILKPVTGELIEEEMAHL 121
Cdd:COG3437   79 RDIPVIFLTALADpeDRERALEAGADDYLTKPFDPEELLARVRNA 123
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
3-116 3.07e-14

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 67.54  E-value: 3.07e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   3 ILATDDEALSLDSLTVTLQKAFPHAEVHSFQQPRKALDFVRflcqrqNTSLDFAFLDVEMPGMTGIELAAELKKLCPDVG 82
Cdd:cd17535    1 VLIVDDHPLVREGLRRLLESEPDIEVVGEAADGEEALALLR------ELRPDVVLMDLSMPGMDGIEALRRLRRRYPDLK 74
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 503144367  83 IFFVTGFAD--YAYEAYRVHARGYILKPVTGELIEE 116
Cdd:cd17535   75 VIVLTAHDDpeYVLRALKAGAAGYLLKDSSPEELIE 110
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
1-210 3.44e-12

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 63.82  E-value: 3.44e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   1 MHILATDDEALSLDSLTVTLQKAfpHAEVHSFQQPRKALDFVRflcqrqNTSLDFAFLDVEMPGMTGIELAAELKKLCPD 80
Cdd:COG0745    2 PRILVVEDDPDIRELLADALERE--GYEVDTAADGEEALELLE------EERPDLILLDLMLPGMDGLEVCRRLRARPSD 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367  81 VGIFFVTGFADyayEAYRVHAR-----GYILKPVT-GELIEEEMAHLAttpppdpfHTRRVRLRTFGTFD-----AFMGA 149
Cdd:COG0745   74 IPIIMLTARDD---EEDRVRGLeagadDYLTKPFDpEELLARIRALLR--------RRAAEVLRVGDLLDlaareVTRDG 142
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 503144367 150 KPIAFSRTRAkELLAYLADRQGSGVTLADICSALFEDESGsktSKKYVQNLISSLKQGLEA 210
Cdd:COG0745  143 EPVELTPKEF-RLLELLMRNPGRVVSREQLLEEVWGYDYG---DDRTVDVHISRLRKKLED 199
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
1-112 4.99e-12

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 63.00  E-value: 4.99e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   1 MHILATDDEALSLDSLTVTLQKAfpHAEVHSFQQPRKALDFVrflcqrQNTSLDFAFLDVEMPGMTGIELAAELKKL--C 78
Cdd:COG3706    2 ARILVVDDDPTNRKLLRRLLEAA--GYEVVEAADGEEALELL------QEHRPDLILLDLEMPDMDGLELCRRLRADprT 73
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 503144367  79 PDVGIFFVTGFADYAY--EAYRVHARGYILKPVTGE 112
Cdd:COG3706   74 ADIPIIFLTALDDEEDraRALEAGADDYLTKPFDPE 109
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
1-109 5.11e-12

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 61.30  E-value: 5.11e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   1 MHILATDDEALSLDSLTVTLQKAfPHAEVHSFQQPRKALDfvrfLCQRQNTslDFAFLDVEMPGMTGIELAAELKKL--C 78
Cdd:cd17551    1 MRILIVDDNPTNLLLLEALLRSA-GYLEVVSFTDPREALA----WCRENPP--DLILLDYMMPGMDGLEFIRRLRALpgL 73
                         90       100       110
                 ....*....|....*....|....*....|...
gi 503144367  79 PDVGIFFVTGFADYA--YEAYRVHARGYILKPV 109
Cdd:cd17551   74 EDVPIVMITADTDREvrLRALEAGATDFLTKPF 106
REC_CpdR_CckA-like cd18160
phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; ...
3-95 7.78e-10

phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; Two-component systems (TCSs), consisting of a sensor and a response regulator, are used by bacteria to adapt to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis and membrane transport. Response regulators share the common phosphoacceptor REC domain and differ output domains such as DNA, RNA, ligand, and protein-binding, or enzymatic domain. CpdR is a stand-alone REC protein. CckA is a sensor histidine kinase containing N-terminal PAS domains and a C-terminal REC domain. CpdR and CckA are components of a regulatory phosphorelay system (composed of CckA, ChpT, CtrA and CpdR) that controls Brucella abortus cell growth, division, and intracellular survival inside mammalian host cells. CckA autophosphorylates in the presence of ATP and transfers a phosphoryl group to the conserved aspartic acid residue on its C-terminal REC domain, which is relayed to the ChpT phosphotransferase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381144 [Multi-domain]  Cd Length: 103  Bit Score: 54.82  E-value: 7.78e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   3 ILATDDEALSLDSLTVTLQKAFPHaeVHSFQQPRKALDFVRflcqrQNTSLDFAFLDVEMPGMTGIELAAELKKLCPDVG 82
Cdd:cd18160    2 ILLADDEPSVRKFIVTTLKKAGYA--VTEAESGAEALEKLQ-----QGKDIDIVVTDIVMPEMDGIELAREARKIDPDVK 74
                         90
                 ....*....|...
gi 503144367  83 IFFVTGFADYAYE 95
Cdd:cd18160   75 ILFISGGAAAAPE 87
DnrI COG3629
DNA-binding transcriptional regulator DnrI/AfsR/EmbR, SARP family, contains BTAD domain ...
134-240 1.02e-09

DNA-binding transcriptional regulator DnrI/AfsR/EmbR, SARP family, contains BTAD domain [Transcription];


Pssm-ID: 442847 [Multi-domain]  Cd Length: 244  Bit Score: 57.54  E-value: 1.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367 134 RVRLRTFGTFDAFMGAKPIAFSRTRAKELLAYLADRQGSGVTLADICSALFEDESgSKTSKKYVQNLISSLKQGLEAVGA 213
Cdd:COG3629    1 PLRFRLLGPLEVRVDGRPVPLGGPKQRALLAYLALRAGRPVSRDRLADLLWGDDP-PASARANLRTYVSRLRRALGPAGG 79
                         90       100
                 ....*....|....*....|....*..
gi 503144367 214 GDILIKKWNYlALDTQKVDCDYYRFLE 240
Cdd:COG3629   80 DLLVTRGGGY-RLDVDPDEVDLHRFER 105
REC_LytTR_AgrA-like cd17533
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; ...
47-117 1.29e-09

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AgrA-like group of LytTR/AlgR family response regulators are Staphylococcus aureus accessory gene regulator protein A (AgrA) and Streptococcus pneumoniae response regulator ComE, which are members of two-component regulatory systems. AgrA is a global regulator that controls the synthesis of virulence factors and other exoproteins. ComE is part of the ComD-ComE system that is part of a quorum-sensing signaling pathway that controls the development of competence, a physiological state required for genetic transformation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381088 [Multi-domain]  Cd Length: 131  Bit Score: 54.94  E-value: 1.29e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 503144367  47 QRQNTSLDFAFLDVEMPGMTGIELAAELKKLCPDVGIFFVTGFADYAYEA--YRVHARGYILKPVTGELIEEE 117
Cdd:cd17533   48 ERGKNGIYFLDIDIKMEEKNGLEVAQKIRKYDPYAIIIFVTTHSEFAPLTfeYKVAALDFILKPLKLEEFKKR 120
REC_DesR-like cd19930
phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of ...
54-107 1.53e-09

phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of Bacillus subtilis DesR, Streptococcus pneumoniae response regulator spr1814, and similar proteins, all containing an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. DesR is a response regulator that, together with its cognate sensor kinase DesK, comprises a two-component regulatory system that controls membrane fluidity. Phosphorylation of the REC domain of DesR is allosterically coupled to two distinct exposed surfaces of the protein, controlling noncanonical dimerization/tetramerization, cooperative activation, and DesK binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381157 [Multi-domain]  Cd Length: 117  Bit Score: 54.59  E-value: 1.53e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 503144367  54 DFAFLDVEMPGMTGIELAAELKKLCPDVGIFFVTGFADYAYEAYRVHA--RGYILK 107
Cdd:cd19930   46 DVAILDIEMPGRTGLEVAAELREELPDTKVLIVTTFGRPGYFRRALAAgvDGYVLK 101
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
3-116 3.94e-09

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 53.24  E-value: 3.94e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   3 ILATDDEALSLDSLTVTLQKAFPhaEVHSFQQPRKALDFVRflcqrqNTSLDFAFLDVEMPGMTGIELAAELKKL---CP 79
Cdd:cd17546    1 VLVVDDNPVNRKVLKKLLEKLGY--EVDVAENGQEALELLK------EEPFDLVLMDLQMPVMDGLEATRRIRELeggGR 72
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 503144367  80 DVGIFFVTGFA--DYAYEAYRVHARGYILKPVTGELIEE 116
Cdd:cd17546   73 RTPIIALTANAleEDREKCLEAGMDDYLSKPVKLDQLKE 111
REC_HupR-like cd17569
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar ...
3-108 7.95e-09

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar domains; This family is composed of mostly uncharacterized response regulators with similarity to the REC domains of response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It contains an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. Members of this family contain a REC domain and various output domains including the cyclase homology domain (CHD) and the c-di-GMP phosphodiesterase domains, HD-GYP and EAL. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381113 [Multi-domain]  Cd Length: 118  Bit Score: 52.41  E-value: 7.95e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   3 ILATDDEALSLDSLTVTLQKAfpHAEVHSFQQPRKALDFVRflcqrqNTSLDFAFLDVEMPGMTGIELAAELKKLCPDVG 82
Cdd:cd17569    3 ILLVDDEPNILKALKRLLRRE--GYEVLTATSGEEALEILK------QEPVDVVISDQRMPGMDGAELLKRVRERYPDTV 74
                         90       100       110
                 ....*....|....*....|....*....|....
gi 503144367  83 IFFVTGFADY--AYEA------YRvhargYILKP 108
Cdd:cd17569   75 RILLTGYADLdaAIEAinegeiYR-----FLTKP 103
PRK11697 PRK11697
two-component system response regulator BtsR;
54-109 8.85e-09

two-component system response regulator BtsR;


Pssm-ID: 236956 [Multi-domain]  Cd Length: 238  Bit Score: 54.47  E-value: 8.85e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 503144367  54 DFAFLDVEMPGMTGIELAAELKklcPDV--GIFFVTGFADYAYEAYRVHARGYILKPV 109
Cdd:PRK11697  49 DVVFLDIQMPRISGLELVGMLD---PEHmpYIVFVTAFDEYAIKAFEEHAFDYLLKPI 103
Spo0F COG5803
Stage 0 sporulation initiation response regulator Spo0F [Cell cycle control, cell division, ...
36-108 1.16e-08

Stage 0 sporulation initiation response regulator Spo0F [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444505 [Multi-domain]  Cd Length: 119  Bit Score: 52.10  E-value: 1.16e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 503144367  36 RKALDFVrflcqrQNTSLDFAFLDVEMPGMTGIELAAELKKLCPDVGIFFVTGFADYAY--EAYRVHARGYILKP 108
Cdd:COG5803   36 KEALEKV------KELKPDLVLLDMKMPGMDGIEILKEIKEIDPDIPVIMMTAYGELDMveEAKELGAKGYFTKP 104
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
3-110 3.23e-08

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 50.87  E-value: 3.23e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   3 ILATDDEALSLDSLTVTLQKaFPHAEVHSFQQPRKALDFVRflcqrqNTSLDFAFLDVEMPG-MTGIELAAELKKLCpDV 81
Cdd:cd17534    3 ILIVEDEAIIALDLKEILES-LGYEVVGIADSGEEAIELAE------ENKPDLILMDINLKGdMDGIEAAREIREKF-DI 74
                         90       100       110
                 ....*....|....*....|....*....|.
gi 503144367  82 GIFFVTGFADYAY--EAYRVHARGYILKPVT 110
Cdd:cd17534   75 PVIFLTAYSDEETleRAKETNPYGYLVKPFN 105
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
54-136 3.52e-08

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 51.84  E-value: 3.52e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367  54 DFAFLDVEMPGMTGIELAAELKKLCPDVGIFFVTGFADY--AYEAYRVHARGYILKPVTGELIEEEMAHL---ATTPPPD 128
Cdd:COG4567   50 DYAVLDLRLGDGSGLDLIEALRERDPDARIVVLTGYASIatAVEAIKLGADDYLAKPADADDLLAALERAegdAPAPPEN 129

                 ....*...
gi 503144367 129 PFHTRRVR 136
Cdd:COG4567  130 PMSLDRLE 137
REC_DctD-like cd17549
phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and ...
3-109 4.05e-08

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381101 [Multi-domain]  Cd Length: 130  Bit Score: 50.95  E-value: 4.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   3 ILATDDEALSLDSLTVTLQKA-FphaEVHSFQQPRKALDFVrflcqrqntSLDFA---FLDVEMPGMTGIELAAELKKLC 78
Cdd:cd17549    1 VLLVDDDADVREALQQTLELAgF---RVRAFADAEEALAAL---------SPDFPgvvISDIRMPGMDGLELLAQIRELD 68
                         90       100       110
                 ....*....|....*....|....*....|...
gi 503144367  79 PDVGIFFVTGFAD--YAYEAYRVHARGYILKPV 109
Cdd:cd17549   69 PDLPVILITGHGDvpMAVEAMRAGAYDFLEKPF 101
REC_RegA-like cd17563
phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; ...
1-115 5.38e-08

phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; Rhodobacter sphaeroides RegA, also called response regulator PrrA, is the DNA binding regulatory protein of a redox-responsive two-component regulatory system RegB/RegA that is involved in transactivating anaerobic expression of the photosynthetic apparatus. It contains a REC domain and a DNA-binding helix-turn-helix output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381111 [Multi-domain]  Cd Length: 112  Bit Score: 50.13  E-value: 5.38e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   1 MHILATDDEALSLDSLTVTLQK-AFphaEVHSFQQPRKALDfvrfLCQRQntSLDFAFLDVEMPGMTGIELAAELKKLCP 79
Cdd:cd17563    1 KSLLLVDDDEVFAERLARALERrGF---EVETAHSVEEALA----LAREE--KPDYAVLDLRLGGDSGLDLIPPLRALQP 71
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 503144367  80 DVGIFFVTGFADY--AYEAYRVHARGYILKPVTGELIE 115
Cdd:cd17563   72 DARIVVLTGYASIatAVEAIKLGADDYLAKPADADEIL 109
REC_FixJ cd17537
phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response ...
7-114 6.81e-08

phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381092 [Multi-domain]  Cd Length: 116  Bit Score: 49.90  E-value: 6.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   7 DDEALSLDSLTVTLQKAFPHAEVHSfqqprKALDFVRFLCQRQNTSLdfaFLDVEMPGMTGIELAAELKKLCPDVGIFFV 86
Cdd:cd17537    7 DDDEAVRDSLAFLLRSVGLAVKTFT-----SASAFLAAAPPDQPGCL---VLDVRMPGMSGLELQDELLARGSNIPIIFI 78
                         90       100       110
                 ....*....|....*....|....*....|
gi 503144367  87 TGFAD--YAYEAYRVHARGYILKPVTGELI 114
Cdd:cd17537   79 TGHGDvpMAVEAMKAGAVDFLEKPFRDQVL 108
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
3-110 1.80e-07

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 48.74  E-value: 1.80e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   3 ILATDDEALSLDSLTVTLqkafphaEVHSFQ-----QPRKALDfvrfLCQRQNTslDFAFLDVEMPGMTGIELAAELKKL 77
Cdd:cd17555    3 ILVIDDDEVVRESIAAYL-------EDSGFQvlqaaDGRQGLE----LFRSEQP--DLVLCDLRMPEMDGLEVLKQITKE 69
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 503144367  78 CPDVGIFFV--TGFADYAYEAYRVHARGYILKPVT 110
Cdd:cd17555   70 SPDTPVIVVsgAGVMSDAVEALRLGAWDYLTKPIE 104
REC_2_DhkD-like cd17580
second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal ...
3-90 2.81e-07

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381118 [Multi-domain]  Cd Length: 112  Bit Score: 47.84  E-value: 2.81e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   3 ILATDDEALSLDSLTVTLQKAfpHAEVHSFQQPRKALDFVrflcqrQNTSLDFAFLDVEMPGMTGIELAAELKKLCPDVG 82
Cdd:cd17580    1 ILVVDDNEDAAEMLALLLELE--GAEVTTAHSGEEALEAA------QRFRPDVILSDIGMPGMDGYELARRLRELPWLAN 72
                         90
                 ....*....|
gi 503144367  83 IFFV--TGFA 90
Cdd:cd17580   73 TPAIalTGYG 82
REC_TrrA-like cd17554
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and ...
36-107 3.00e-07

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381106 [Multi-domain]  Cd Length: 113  Bit Score: 47.99  E-value: 3.00e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 503144367  36 RKALDFVrflcqrQNTSLDFAFLDVEMPGMTGIELAAELKKLCPDVGIFFVTGFADYAYEAYRVHARGYILK 107
Cdd:cd17554   34 EEALEKL------ESEDPDLVILDIKMPGMDGLETLRKIREKKPDLPVIICTAYSEYKSDFSSWAADAYVVK 99
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
7-115 3.70e-07

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 49.33  E-value: 3.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   7 DDEALSLDSLTVTLQKAfpHAEVHSFQQprkALDFVRFLCQRQNTSLdfaFLDVEMPGMTGIELAAELKKLCPDVGIFFV 86
Cdd:COG4566    6 DDDEAVRDSLAFLLESA--GLRVETFAS---AEAFLAALDPDRPGCL---LLDVRMPGMSGLELQEELAARGSPLPVIFL 77
                         90       100       110
                 ....*....|....*....|....*....|..
gi 503144367  87 TGFAD--YAYEAYRVHARGYILKPVTGE-LIE 115
Cdd:COG4566   78 TGHGDvpMAVRAMKAGAVDFLEKPFDDQaLLD 109
PRK14084 PRK14084
DNA-binding response regulator;
1-116 4.20e-07

DNA-binding response regulator;


Pssm-ID: 184495 [Multi-domain]  Cd Length: 246  Bit Score: 49.75  E-value: 4.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   1 MHILATDDEALSLDSLTVTLQkafphaEVHSFQQPRKALDFVRFLCQRQNTSLDFAFLDVEMPGMTGIELAAELKKLCPD 80
Cdd:PRK14084   1 MKALIVDDEPLARNELTYLLN------EIGGFEEINEAENVKETLEALLINQYDIIFLDINLMDESGIELAAKIQKMKEP 74
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 503144367  81 VGIFFVTGFADYAYEAYRVHARGYILKPVTGELIEE 116
Cdd:PRK14084  75 PAIIFATAHDQFAVKAFELNATDYILKPFEQKRIEQ 110
PRK15369 PRK15369
two component system response regulator;
3-107 4.70e-07

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 49.31  E-value: 4.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   3 ILATDDEALSLDSLTVTLQkAFPHAEVhsFQQPRKALDfVRFLCQRqnTSLDFAFLDVEMPGMTGIELAAELKKLCPDVG 82
Cdd:PRK15369   6 ILLVDDHELIINGIKNMLA-PYPRYKI--VGQVDNGLE-VYNACRQ--LEPDIVILDLGLPGMNGLDVIPQLHQRWPAMN 79
                         90       100
                 ....*....|....*....|....*..
gi 503144367  83 IFFVTGFAD--YAYEAYRVHARGYILK 107
Cdd:PRK15369  80 ILVLTARQEehMASRTLAAGALGYVLK 106
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
1-74 7.97e-07

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 47.19  E-value: 7.97e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 503144367   1 MHILATDDEALSLDSLTVTLQKAFPHAEVHSFQQPRKALDFVRflcqrqNTSLDFAFLDVEMPGMTGIELAAEL 74
Cdd:COG2197    2 IRVLIVDDHPLVREGLRALLEAEPDIEVVGEAADGEEALELLE------ELRPDVVLLDIRMPGMDGLEALRRL 69
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
2-115 1.30e-06

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 46.14  E-value: 1.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   2 HILATDDEALSLDSLTVTLQKAFPhaevhsfqQPRKALDFVRFLCQRQNTSLDFAFLDVEMPGMTGIELAAELKKLcP-- 79
Cdd:cd17562    2 KILAVDDSASIRQMVSFTLRGAGY--------EVVEAADGRDALSKAQSKKFDLIITDQNMPNMDGIELIKELRKL-Pay 72
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 503144367  80 -DVGIFFVTGFADYAY--EAYRVHARGYILKP-VTGELIE 115
Cdd:cd17562   73 kFTPILMLTTESSDEKkqEGKAAGATGWLVKPfDPEQLLE 112
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
7-108 1.33e-06

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 45.86  E-value: 1.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   7 DDEALSLDSLTVTLQKAfpHAEVHSFQQPRKALDFVRflcqrqNTSLDFAFLDVEMPGMTGIELAAELKKLCPDVGIFFV 86
Cdd:cd17574    4 EDDEEIAELLSDYLEKE--GYEVDTAADGEEALELAR------EEQPDLIILDVMLPGMDGFEVCRRLREKGSDIPIIML 75
                         90       100
                 ....*....|....*....|....*....
gi 503144367  87 TGFADyayEAYRVhaRG-------YILKP 108
Cdd:cd17574   76 TAKDE---EEDKV--LGlelgaddYITKP 99
REC_HupR cd17596
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of ...
3-91 1.44e-06

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of this subfamily are response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It belongs to the nitrogen regulatory protein C (NtrC) family of response regulators, which activate transcription by RNA polymerase (RNAP) in response to a change in the environment. HupR is an unusual member of this family as it activates transcription when unphosphorylated, and transcription is inhibited by phosphorylation. Proteins in this subfamily contain an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381127 [Multi-domain]  Cd Length: 133  Bit Score: 46.59  E-value: 1.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   3 ILATDDEALSLDSLTVTLQKAFphaEVHSFQQPRKALDFVR------FLCqrqntsldfaflDVEMPGMTGIELAAELKK 76
Cdd:cd17596    3 ILVVDDEVRSLEALRRTLEEDF---DVLTAASAEEALAILEeewvqvILC------------DQRMPGTTGVEFLKEVRE 67
                         90
                 ....*....|....*
gi 503144367  77 LCPDVGIFFVTGFAD 91
Cdd:cd17596   68 RWPEVVRIIISGYTD 82
REC_Rcp-like cd17557
phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and ...
4-112 3.98e-06

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381108 [Multi-domain]  Cd Length: 129  Bit Score: 45.10  E-value: 3.98e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   4 LATDDEAlslDSLTVT--LQKAFPHAEVHSFQQPRKALDFVRFLCQRQNTSL-DFAFLDVEMPGMTGIELAAELK----- 75
Cdd:cd17557    4 LVEDNPG---DAELIQeaFKEAGVPNELHVVRDGEEALDFLRGEGEYADAPRpDLILLDLNMPRMDGFEVLREIKadpdl 80
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 503144367  76 KLCPdVGIFFVTGFADYAYEAYRVHARGYILKPVTGE 112
Cdd:cd17557   81 RRIP-VVVLTTSDAEEDIERAYELGANSYIVKPVDFE 116
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
7-108 4.34e-06

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 44.96  E-value: 4.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   7 DDEalslDSLTVTLQKAFPHA--EVHSFQQPRKALDfvrflcQRQNTSLDFAFLDVEMPGMTGIELAAELKKLCPDVGIF 84
Cdd:cd19919    7 DDD----SSIRWVLERALAGAglTVTSFENAQEALA------ALASSQPDVLISDIRMPGMDGLALLAQIKQRHPDLPVI 76
                         90       100
                 ....*....|....*....|....*.
gi 503144367  85 FVTGFADY--AYEAYRVHARGYILKP 108
Cdd:cd19919   77 IMTAHSDLdsAVSAYQGGAFEYLPKP 102
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
3-108 6.34e-06

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 47.15  E-value: 6.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   3 ILATDDEALSLDSLTVTLQKAfpHAEVHSFQQPRKALDfvRFLCQRqntsLDFAFLDVEMPGMTGIELAAELKKLCPDVG 82
Cdd:PRK11361   7 ILIVDDEDNVRRMLSTAFALQ--GFETHCANNGRTALH--LFADIH----PDVVLMDIRMPEMDGIKALKEMRSHETRTP 78
                         90       100
                 ....*....|....*....|....*...
gi 503144367  83 IFFVTGFADY--AYEAYRVHARGYILKP 108
Cdd:PRK11361  79 VILMTAYAEVetAVEALRCGAFDYVIKP 106
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
27-112 7.78e-06

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 44.16  E-value: 7.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367  27 AEVHSFQQPRKALDfvrflcqrqNTSLDFAFLDVEMPGMTGIELAAELKKLCPDVGIFFVTGFADYAY--EAYRVHARGY 104
Cdd:cd19925   30 GTAGTGEEALKLLK---------ERQPDLILLDIYLPDGNGLDLLRELRAAGHDVDVIVVTAANDVETvrEALRLGVVDY 100

                 ....*...
gi 503144367 105 ILKPVTGE 112
Cdd:cd19925  101 LIKPFTFE 108
REC_NtrX-like cd17550
phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...
3-108 2.07e-05

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381102 [Multi-domain]  Cd Length: 115  Bit Score: 42.87  E-value: 2.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   3 ILATDDEALSLDSLTVTLQKafphaEVHsfqQPRKALDFVRFLCQRQNTSLDFAFLDVEMPGMTGIELAAELKKLCPDVG 82
Cdd:cd17550    1 ILIVDDEEDIRESLSGILED-----EGY---EVDTAADGEEALKLIKERRPDLVLLDIWLPDMDGLELLKEIKEKYPDLP 72
                         90       100
                 ....*....|....*....|....*...
gi 503144367  83 IFFVTGFA--DYAYEAYRVHARGYILKP 108
Cdd:cd17550   73 VIMISGHGtiETAVKATKLGAYDFIEKP 100
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
1-114 2.80e-05

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 43.79  E-value: 2.80e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   1 MHILATDDEALSLDSLTVTLQKAfPHAEVHSFQQPRKALDFVRflcqrqNTSLDFAFLDVEMPGMTGIELAAEL--KKLC 78
Cdd:COG3707    4 LRVLVVDDEPLRRADLREGLREA-GYEVVAEAADGEDAVELVR------ELKPDLVIVDIDMPDRDGLEAARQIseERPA 76
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 503144367  79 PDVgifFVTGFADYAY--EAYRVHARGYILKPVTGELI 114
Cdd:COG3707   77 PVI---LLTAYSDPELieRALEAGVSAYLVKPLDPEDL 111
fixJ PRK09390
response regulator FixJ; Provisional
7-108 2.81e-05

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 43.84  E-value: 2.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   7 DDEALSlDSLTVTLQKA-FphaEVHSFQQprkALDFVRFLcqrqnTSLDFAFL--DVEMPGMTGIELAAELKKLCPDVGI 83
Cdd:PRK09390  11 DDEAMR-DSLAFLLDSAgF---EVRLFES---AQAFLDAL-----PGLRFGCVvtDVRMPGIDGIELLRRLKARGSPLPV 78
                         90       100
                 ....*....|....*....|....*..
gi 503144367  84 FFVTGFAD--YAYEAYRVHARGYILKP 108
Cdd:PRK09390  79 IVMTGHGDvpLAVEAMKLGAVDFIEKP 105
PRK10365 PRK10365
sigma-54-dependent response regulator transcription factor ZraR;
45-120 3.61e-05

sigma-54-dependent response regulator transcription factor ZraR;


Pssm-ID: 182412 [Multi-domain]  Cd Length: 441  Bit Score: 44.64  E-value: 3.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367  45 LCQRQNTSLDFAFLDVEMPGMTGIELAAELKKLCPDVGIFFVTGFA--DYAYEAYRVHARGYILKPVT----GELIEEEM 118
Cdd:PRK10365  42 LEQVREQVFDLVLCDVRMAEMDGIATLKEIKALNPAIPVLIMTAYSsvETAVEALKTGALDYLIKPLDfdnlQATLEKAL 121

                 ..
gi 503144367 119 AH 120
Cdd:PRK10365 122 AH 123
PRK13557 PRK13557
histidine kinase; Provisional
29-95 5.60e-05

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 44.28  E-value: 5.60e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503144367  29 VHSFQQPRKALDFVRflcqrQNTSLDFAFLDVEMPG-MTGIELAAELKKLCPDVGIFFVTGFADYAYE 95
Cdd:PRK13557 442 TLVASNGREALEILD-----SHPEVDLLFTDLIMPGgMNGVMLAREARRRQPKIKVLLTTGYAEASIE 504
REC_typeB_ARR-like cd17584
phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and ...
3-112 5.69e-05

phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains; Type-B ARRs (Arabidopsis response regulators) are a class of MYB-type transcription factors that act as major players in the transcriptional activation of cytokinin-responsive genes. They directly regulate the expression of type-A ARR genes and other downstream target genes. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Cytokinin signaling involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-B ARRs contain a receiver (REC) domain and a large C-terminal extension that has characteristics of an effector or output domain, with a Myb-like DNA binding domain referred to as the GARP domain. The GARP domain is a motif specific to plant transcription factors. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381121 [Multi-domain]  Cd Length: 115  Bit Score: 41.46  E-value: 5.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   3 ILATDDEALSLDSLTVTLQKAfpHAEVHSFQQPRKALDFVRflcQRQNtSLDFAFLDVEMPGMTGIELAAELKKLCpDVG 82
Cdd:cd17584    1 VLVVDDDPTCLAILKRMLLRC--GYQVTTCTDAEEALSMLR---ENKD-EFDLVITDVHMPDMDGFEFLELIRLEM-DLP 73
                         90       100       110
                 ....*....|....*....|....*....|....
gi 503144367  83 IFFVTgfADYA-YEAYRVHARG---YILKPVTGE 112
Cdd:cd17584   74 VIMMS--ADGStSTVMKGLAHGacdYLLKPVSIE 105
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
54-118 7.34e-05

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 41.50  E-value: 7.34e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 503144367  54 DFAFLDVEMPGMTGIELAAELKKLCPDVGIFFVTGFADYAY--EAYRVHARGYILKPVTGELIEEEM 118
Cdd:cd17542   47 DLVTMDITMPEMDGIEALKEIKKIDPNAKVIMCSAMGQEEMvkEAIKAGAKDFIVKPFQPERVLEAV 113
REC_hyHK_blue-like cd18161
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators ...
50-109 1.42e-04

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators similar to Pseudomonas savastanoi blue-light-activated histidine kinase; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase (HK)/response regulators contain all the elements of a classical TCS in a single polypeptide chain. Pseudomonas savastanoi blue-light-activated histidine kinase is a photosensitive HK and RR that is involved in increased bacterial virulence upon exposure to light. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381145 [Multi-domain]  Cd Length: 102  Bit Score: 40.02  E-value: 1.42e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 503144367  50 NTSLDFAFLDVEMPG-MTGIELAAELKKLCPDVGIFFVTGFADYAYEAYRvHARGY--ILKPV 109
Cdd:cd18161   41 GPDIDLLVTDVIMPGgMNGSQLAEEARRRRPDLKVLLTSGYAENAIEGGD-LAPGVdvLSKPF 102
REC_CheY_CheY3 cd19923
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY ...
1-118 1.50e-04

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY3, Escherichia coli CheY, and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381150 [Multi-domain]  Cd Length: 119  Bit Score: 40.40  E-value: 1.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   1 MHILATDDEALSLDSLTVTLQKAFphaevhsFQQPRKALDFVRFLCQRQNTSLDFAFLDVEMPGMTGIELA------AEL 74
Cdd:cd19923    1 MKVLVVDDFSTMRRIIKNLLKELG-------FNNVEEAEDGVDALEKLKAGGFDFVITDWNMPNMDGLELLktiradGAL 73
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 503144367  75 KklcpDVGIFFVTGFADYAY--EAYRVHARGYILKPVTGELIEEEM 118
Cdd:cd19923   74 S----HLPVLMVTAEAKKENviAAAQAGVNNYIVKPFTAATLKEKL 115
REC_Spo0F-like cd17553
phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone ...
3-108 1.57e-04

phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone response regulator containing only a REC domain with no output/effector domain, controls sporulation in Bacillus subtilis through the exchange of a phosphoryl group. Bacillus subtilis forms spores when conditions for growth become unfavorable. The initiation of sporulation is controlled by a phosphorelay (an expanded version of the two-component system) that consists of four main components: a histidine kinase (KinA), a secondary messenger (Spo0F), a phosphotransferase (Spo0B), and a transcription factor (Spo0A). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381105 [Multi-domain]  Cd Length: 117  Bit Score: 40.23  E-value: 1.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   3 ILATDDEalslDSLTVTLQKAFPHAEVHSFQQP--RKALDFVRflcqrqNTSLDFAFLDVEMPGMTGIELAAELKKLCPD 80
Cdd:cd17553    3 ILIVDDQ----YGIRILLNEVFNKEGYQTFQAAngLQALDIVT------KERPDLVLLDMKIPGMDGIEILKRMKVIDEN 72
                         90       100       110
                 ....*....|....*....|....*....|
gi 503144367  81 VGIFFVTGFA--DYAYEAYRVHARGYILKP 108
Cdd:cd17553   73 IRVIIMTAYGelDMIQESKELGALTHFAKP 102
REC_CheV-like cd19924
phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This ...
14-108 1.69e-04

phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This subfamily includes the REC domains of Bacillus subtilis chemotaxis protein CheV, Myxococcus xanthus gliding motility regulatory protein FrzE, and similar proteins. CheV is a hybrid protein with an N-terminal CheW-like domain and a C-terminal CheY-like REC domain. The CheV pathway is one of three systems employed by B. subtilis for sensory adaptation that contribute to chemotaxis. It is involved in the transmission of sensory signals from chemoreceptors to flagellar motors. Together with CheW, it is involved in the coupling of methyl-accepting chemoreceptors to the central two-component histidine kinase CheA. FrzE is a hybrid sensor histidine kinase/response regulator that is part of the Frz pathway that controls cell reversal frequency to support directional motility during swarming and fruiting body formation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381151 [Multi-domain]  Cd Length: 111  Bit Score: 40.05  E-value: 1.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367  14 DSLTV--TLQKAFPHA--EVHSFQQPRKALDFVRFLCQ---RQNTSLDFAFLDVEMPGMTGIELAAELKK--LCPDVGIF 84
Cdd:cd19924    6 DSPTArkQLRDLLKNLgfEIAEAVDGEEALNKLENLAKegnDLSKELDLIITDIEMPKMDGYELTFELRDdpRLANIPVI 85
                         90       100
                 ....*....|....*....|....*..
gi 503144367  85 FVTGFADyAYEAYRVHARG---YILKP 108
Cdd:cd19924   86 LNSSLSG-EFSRARGKKVGadaYLAKF 111
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
1-109 1.75e-04

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 40.09  E-value: 1.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   1 MHILATDDEALSLDSLTVTLQKAfPHAEVHSFQQPRKALDfvrfLCQRQNTslDFAFLDVEMPGMTGIELAAELKKLCPd 80
Cdd:cd19932    1 VRVLIAEDEALIRMDLREMLEEA-GYEVVGEASDGEEAVE----LAKKHKP--DLVIMDVKMPRLDGIEAAKIITSENI- 72
                         90       100       110
                 ....*....|....*....|....*....|.
gi 503144367  81 VGIFFVTGFA--DYAYEAYRVHARGYILKPV 109
Cdd:cd19932   73 APIVLLTAYSqqDLVERAKEAGAMAYLVKPF 103
PRK11083 PRK11083
DNA-binding response regulator CreB; Provisional
1-108 1.95e-04

DNA-binding response regulator CreB; Provisional


Pssm-ID: 236838 [Multi-domain]  Cd Length: 228  Bit Score: 41.49  E-value: 1.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   1 MHILATDDEALSLDSLTVTLQkafphAE---VHSFQQPRKALDFVRflcqrqNTSLDFAFLDVEMPGMTGIELAAELKKL 77
Cdd:PRK11083   4 PTILLVEDEQAIADTLVYALQ-----SEgftVEWFERGLPALDKLR------QQPPDLVILDVGLPDISGFELCRQLLAF 72
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 503144367  78 CPDVGIFFVTGFADyayEAYRV-----HARGYILKP 108
Cdd:PRK11083  73 HPALPVIFLTARSD---EVDRLvgleiGADDYVAKP 105
PRK09935 PRK09935
fimbriae biosynthesis transcriptional regulator FimZ;
15-107 4.44e-04

fimbriae biosynthesis transcriptional regulator FimZ;


Pssm-ID: 182154 [Multi-domain]  Cd Length: 210  Bit Score: 40.63  E-value: 4.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367  15 SLTVTLQKAFPHAEVHSFQQPRKALDFVRflcqrqNTSLDFAFLDVEMPGMTGIELAAELKKLCPDVGIFFVTGFAD--Y 92
Cdd:PRK09935  18 SIEVLLQKNSELQIVLKTDDYRITIDYLR------TRPVDLIIMDIDLPGTDGFTFLKRIKQIQSTVKVLFLSSKSEcfY 91
                         90
                 ....*....|....*
gi 503144367  93 AYEAYRVHARGYILK 107
Cdd:PRK09935  92 AGRAIQAGANGFVSK 106
PRK10610 PRK10610
chemotaxis protein CheY;
32-118 6.94e-04

chemotaxis protein CheY;


Pssm-ID: 170568 [Multi-domain]  Cd Length: 129  Bit Score: 38.80  E-value: 6.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367  32 FQQPRKALDFVRFLCQRQNTSLDFAFLDVEMPGMTGIELaaeLKKLCPDVG-----IFFVTGFA--DYAYEAYRVHARGY 104
Cdd:PRK10610  30 FNNVEEAEDGVDALNKLQAGGFGFVISDWNMPNMDGLEL---LKTIRADGAmsalpVLMVTAEAkkENIIAAAQAGASGY 106
                         90
                 ....*....|....
gi 503144367 105 ILKPVTGELIEEEM 118
Cdd:PRK10610 107 VVKPFTAATLEEKL 120
REC_PilR cd19926
phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR ...
3-108 1.05e-03

phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR and similar proteins; Pseudomonas aeruginosa PilR is the response regulator of the PilS/PilR two-component regulatory system (PilSR TCS) that acts in conjunction with sigma-54 to regulate the expression of type 4 pilus (T4P) major subunit PilA. In addition, the PilSR TCS regulates flagellum-dependent swimming motility and pilus-dependent twitching motility. PilR contains an N-terminal REC domain, a central sigma-54 interaction domain, and a C-terminal Fis-type helix-turn-helix DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381153 [Multi-domain]  Cd Length: 100  Bit Score: 37.52  E-value: 1.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   3 ILATDDEALSLDSLTVTLQKAfpHAEVHSFQQPRKAldfvRFLCQRQNTSLdfAFLDVEMPGMTGIELAAELKKLCPDVG 82
Cdd:cd19926    1 VLVVDDEPDIRELLEITLGRM--GLDVRSARNVKEA----RELLASEPYDL--CLTDMRLPDGSGLELVQHIQQRLPQTP 72
                         90       100
                 ....*....|....*....|....*...
gi 503144367  83 IFFVTGF--ADYAYEAYRVHARGYILKP 108
Cdd:cd19926   73 VAVITAYgsLDTAIEALKAGAFDFLTKP 100
orf27 CHL00148
Ycf27; Reviewed
1-116 1.78e-03

Ycf27; Reviewed


Pssm-ID: 214376 [Multi-domain]  Cd Length: 240  Bit Score: 38.93  E-value: 1.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   1 MHILATDDEALSLDSLTVTLqkAFPHAEVHSFQQPRKALDFVRFLCQrqntslDFAFLDVEMPGMTGIELAAELKKLcPD 80
Cdd:CHL00148   7 EKILVVDDEAYIRKILETRL--SIIGYEVITASDGEEALKLFRKEQP------DLVILDVMMPKLDGYGVCQEIRKE-SD 77
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 503144367  81 VGIFFVTGFADYA--YEAYRVHARGYILKPVTGELIEE 116
Cdd:CHL00148  78 VPIIMLTALGDVSdrITGLELGADDYVVKPFSPKELEA 115
CadC1 COG3710
DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];
148-219 2.29e-03

DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];


Pssm-ID: 442924 [Multi-domain]  Cd Length: 106  Bit Score: 36.81  E-value: 2.29e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 503144367 148 GAKPIAFSRtRAKELLAYLADRQGSGVTLADICSALFEDESGSKTSkkyVQNLISSLKQGLEAVGAGDILIK 219
Cdd:COG3710   20 DGEPVRLSP-RAFDLLLLLLEHPGRVVSRDELLAAVWPGRVVSDNS---LTQAISRLRKALGDDGLEPRLIR 87
REC_ETR-like cd19933
phosphoacceptor receiver (REC) domain of plant ethylene receptors ETR1, ETR2, and EIN4, and ...
47-79 3.16e-03

phosphoacceptor receiver (REC) domain of plant ethylene receptors ETR1, ETR2, and EIN4, and similar proteins; Plant ethylene receptors contain N-terminal transmembrane domains that contain an ethylene binding site and also serve in localization of the receptor to the endoplasmic reticulum or the Golgi apparatus and a C-terminal histidine kinase (HK)-like domain. There are five ethylene receptors (ETR1, ERS1, ETR2, ERS2, and EIN4) in Arabidopsis thaliana. ETR1, ETR2, and EIN4 also contain REC domains C-terminal to the HK domain. ETR1 and ERS1 belong to subfamily 1, and have functional HK domains while ETR2, ERS2, and EIN4 belong to subfamily 2, and lack the necessary residues for HK activity and may function as serine/threonine kinases. The plant hormone ethylene plays an important role in plant growth and development. It regulates seed germination, seedling growth, leaf and petal abscission, fruit ripening, organ senescence, and pathogen responses. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381160 [Multi-domain]  Cd Length: 117  Bit Score: 36.61  E-value: 3.16e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 503144367  47 QRQNTSLDFAFLDVEMPGMTGIELAAELKKLCP 79
Cdd:cd19933   41 ASAEHSFQLVLLDLCMPEMDGFEVALRIRKLFG 73
Trans_reg_C smart00862
Transcriptional regulatory protein, C terminal; This domain is almost always found associated ...
150-218 3.42e-03

Transcriptional regulatory protein, C terminal; This domain is almost always found associated with the response regulator receiver domain. It may play a role in DNA binding.


Pssm-ID: 214866 [Multi-domain]  Cd Length: 76  Bit Score: 35.61  E-value: 3.42e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 503144367   150 KPIAFSRTRAkELLAYLADRQGSGVTLADICSALFEDESGSktSKKYVQNLISSLKQGLEAVGAGDILI 218
Cdd:smart00862   2 EPIKLTPKEF-RLLELLLRNPGRVVSREELLEAVWGDDEDV--DDNTLDVHISRLRKKLEDDGDPRLIE 67
REC_OmpR_ArcA_TorR-like cd17619
phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; ...
2-88 3.95e-03

phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; This subfamily includes Escherichia coli TorR and ArcA, both OmpR family response regulators that mediate adaptation to changes in various respiratory growth conditions. The TorS-TorR two-component system (TCS) is responsible for the tight regulation of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase respiratory system in response to anaerobic conditions and the presence of TMAO. The ArcA-ArcB TCS is involved in cell growth during anaerobiosis. ArcA is a global regulator that controls more than 30 operons involved in redox regulation (the Arc modulon). OmpR family DNA-binding response regulators are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381134 [Multi-domain]  Cd Length: 113  Bit Score: 36.21  E-value: 3.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   2 HILATDDEALSLDSLtvtlqKAFPHAEVHSFQQPRKALDFVRFLcqrQNTSLDFAFLDVEMPGMTGIELAAELKKLCpDV 81
Cdd:cd17619    2 HILIVEDEPVTRATL-----KSYFEQEGYDVSEAGDGEEMRQIL---ARQDIDLVLLDINLPGKDGLSLTRELREQS-EV 72

                 ....*..
gi 503144367  82 GIFFVTG 88
Cdd:cd17619   73 GIILVTG 79
REC_CheB-like cd17541
phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate ...
58-111 4.41e-03

phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate methylesterase CheB and similar chemotaxis proteins; Methylesterase CheB is a chemotaxis response regulator with an N-terminal REC domain and a C-terminal methylesterase domain. Chemotaxis is a behavior known in motile bacteria that directs their movement in response to chemical gradients. CheB is a phosphorylation-activated response regulator involved in the reversible modification of bacterial chemotaxis receptors. It catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. The CheB REC domain packs against the active site of the C-terminal domain and inhibits methylesterase activity by directly restricting access to the active site. Also included in this family is chemotaxis response regulator CheY, which contains a stand-alone REC domain, and an uncharacterized subfamily composed of proteins containing an N-terminal REC domain and a C-terminal CheY-P phosphatase (CheC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381096 [Multi-domain]  Cd Length: 125  Bit Score: 36.22  E-value: 4.41e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 503144367  58 LDVEMPGMTGIELAAELKKLCPdVGIFFVTGF----ADYAYEAYRVHARGYILKPVTG 111
Cdd:cd17541   52 LDIEMPVMDGLEALRRIMAERP-TPVVMVSSLteegAEITLEALELGAVDFIAKPSGG 108
REC_PA4781-like cd19920
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar ...
58-109 5.26e-03

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains; Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381147 [Multi-domain]  Cd Length: 103  Bit Score: 35.56  E-value: 5.26e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 503144367  58 LDVEMPGMTGIELAAELKK--LCPDVGIFFVTGFADYA--YEAYRVHARGYILKPV 109
Cdd:cd19920   48 LDVMMPGMDGFEVCRRLKAdpATRHIPVIFLTALTDTEdkVKGFELGAVDYITKPF 103
REC_OmpR_BsPhoP-like cd19937
phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus ...
4-76 8.51e-03

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381164 [Multi-domain]  Cd Length: 116  Bit Score: 35.33  E-value: 8.51e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 503144367   4 LATDDEALSLDSLTVTLQKAfpHAEVHSFQQPRKALDFVRflcqrqNTSLDFAFLDVEMPGMTGIELAAELKK 76
Cdd:cd19937    1 LVVDDEEDIVELLKYNLEKE--GYEVVTAYDGEEALKRAK------DEKPDLIILDLMLPGIDGLEVCRILRS 65
REC_OmpR_ChvI-like cd19936
phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; ...
3-108 8.87e-03

phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; Sinorhizobium meliloti ChvI is part of the ExoS/ChvI two-component regulatory system (TCS) that is required for nitrogen-fixing symbiosis and exopolysaccharide synthesis. ExoS/ChvI also play important roles in regulating biofilm formation, motility, nutrient utilization, and the viability of free-living bacteria. ChvI belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381163 [Multi-domain]  Cd Length: 99  Bit Score: 35.11  E-value: 8.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   3 ILATDDEALSLDSLTVTLQ-KAFphaEVHSFQQPRKALDFVrflcqrqNTSL-DFAFLDVEMPGMTGIELAAELKKLcPD 80
Cdd:cd19936    1 IALVDDDRNILTSVSMALEaEGF---SVETYTDGASALDGL-------NARPpDLAILDIKMPRMDGMELLQRLRQK-ST 69
                         90       100       110
                 ....*....|....*....|....*....|
gi 503144367  81 VGIFFVTGFADYAYEAY--RVHARGYILKP 108
Cdd:cd19936   70 LPVIFLTSKDDEIDEVFglRMGADDYITKP 99
PRK10766 PRK10766
two-component system response regulator TorR;
2-91 9.50e-03

two-component system response regulator TorR;


Pssm-ID: 182711 [Multi-domain]  Cd Length: 221  Bit Score: 36.55  E-value: 9.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503144367   2 HILATDDEALSLDSLTVTLQKA-FPHAEVHSFQQPRKALdfvrflcqrQNTSLDFAFLDVEMPGMTGIELAAELKKLcPD 80
Cdd:PRK10766   4 HILVVEDEPVTRARLQGYFEQEgYTVSEAASGAGMREIM---------QNQHVDLILLDINLPGEDGLMLTRELRSR-ST 73
                         90
                 ....*....|.
gi 503144367  81 VGIFFVTGFAD 91
Cdd:PRK10766  74 VGIILVTGRTD 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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