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Conserved domains on  [gi|500802673|ref|WP_011998823|]
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MULTISPECIES: P-type DNA transfer ATPase VirB11 [Vibrio]

Protein Classification

P-loop NTPase family protein( domain architecture ID 1562424)

P-loop NTPase (nucleoside triphosphate hydrolase) family protein contains two conserved sequence signatures, the Walker A motif (the P-loop proper) and Walker B motif which bind, respectively, the beta and gamma phosphate moieties of the bound nucleotide (typically ATP or GTP), and a Mg(2+) cation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
 22-326 3.33e-126

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member TIGR02788:

Pssm-ID: 476819  Cd Length: 308  Bit Score: 363.98  E-value: 3.33e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673   22 YLDLEGLTEIAINRPNEVWFDRGNGWERDALPNLSLNMCSNLAKALATFAGLTIplGEANPVASVIFPDGERGQIAIPPA 101
Cdd:TIGR02788   1 FLDDEDVTEICINRPGEVWVEGPGGWQRFDVPDLTFSHLMRLARAIASFSKQSI--SEENPILSATLPGGERVQIVIPPA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673  102 TENGIVSMTIRKPSLTRFALSSYQESGRFSDFREmdvNRVELTPVQEQLLTLKQNGDMSQFFSMAVKSKLNILLVGGTGS 181
Cdd:TIGR02788  79 CENDTVSITIRKPSLVDFSLDDYEEKGFFDTVRA---QSGTLSDNDEQLLELLDAGDIKEFLRLAIASRKNIIISGGTGS 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673  182 GKTTVMKAMVDEYPTDKRLFTIEDVHELDLPnHPNHLHLFYKQGG-----LTPKQIIESCMRMKPDHVLLAELRGDEAWT 256
Cdd:TIGR02788 156 GKTTFLKSLVDEIPKDERIITIEDTREIFLP-HPNYVHLFYSKGGqglakVTPKDLLQSCLRMRPDRIILGELRGDEAFD 234

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 500802673  257 YLEMLNTGHEGSITTIHANDCYSTPARLAGLVKQSEVGQTLDYHHIMRTIRTSIDVIAFFKHT----HLVELFY 326
Cdd:TIGR02788 235 FIRAVNTGHPGSITTLHAGSPEEAFEQLALMVKSSQAGLGLDFAYIVKLVREVIDIVVQINRRgggrKITEVYF 308
 
Name Accession Description Interval E-value
VirB11 TIGR02788
P-type DNA transfer ATPase VirB11; The VirB11 protein is found in the vir locus of ...
 22-326 3.33e-126

P-type DNA transfer ATPase VirB11; The VirB11 protein is found in the vir locus of Agrobacterium Ti plasmids where it is involved in the type IV secretion system for DNA transfer. VirB11 is believed to be an ATPase. VirB11 is a homolog of the P-like conjugation system TrbB protein and the Flp pilus sytem protein TadA.


Pssm-ID: 274301  Cd Length: 308  Bit Score: 363.98  E-value: 3.33e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673   22 YLDLEGLTEIAINRPNEVWFDRGNGWERDALPNLSLNMCSNLAKALATFAGLTIplGEANPVASVIFPDGERGQIAIPPA 101
Cdd:TIGR02788   1 FLDDEDVTEICINRPGEVWVEGPGGWQRFDVPDLTFSHLMRLARAIASFSKQSI--SEENPILSATLPGGERVQIVIPPA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673  102 TENGIVSMTIRKPSLTRFALSSYQESGRFSDFREmdvNRVELTPVQEQLLTLKQNGDMSQFFSMAVKSKLNILLVGGTGS 181
Cdd:TIGR02788  79 CENDTVSITIRKPSLVDFSLDDYEEKGFFDTVRA---QSGTLSDNDEQLLELLDAGDIKEFLRLAIASRKNIIISGGTGS 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673  182 GKTTVMKAMVDEYPTDKRLFTIEDVHELDLPnHPNHLHLFYKQGG-----LTPKQIIESCMRMKPDHVLLAELRGDEAWT 256
Cdd:TIGR02788 156 GKTTFLKSLVDEIPKDERIITIEDTREIFLP-HPNYVHLFYSKGGqglakVTPKDLLQSCLRMRPDRIILGELRGDEAFD 234

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 500802673  257 YLEMLNTGHEGSITTIHANDCYSTPARLAGLVKQSEVGQTLDYHHIMRTIRTSIDVIAFFKHT----HLVELFY 326
Cdd:TIGR02788 235 FIRAVNTGHPGSITTLHAGSPEEAFEQLALMVKSSQAGLGLDFAYIVKLVREVIDIVVQINRRgggrKITEVYF 308
VirB11-like_ATPase cd01130
Type IV secretory pathway component VirB11-like; Type IV secretory pathway component VirB11, ...
 159-328 1.20e-66

Type IV secretory pathway component VirB11-like; Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir (virulence) proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the bacterial Ti (tumor-inducing)-plasmid into plant cells. The pilus is a fibrous cell surface organelle, which mediates adhesion between bacteria during conjugative transfer or between bacteria and host eukaryotic cells during infection. VirB11-related ATPases include Sulfolobus acidocaldarius FlaI, which plays key roles in archaellum (archaeal flagellum) assembly and motility functions, and the pilus assembly proteins CpaF/TadA and TrbB. This alignment contains the C-terminal domain, which is the ATPase.


Pssm-ID: 410874 [Multi-domain]  Cd Length: 177  Bit Score: 207.39  E-value: 1.20e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673 159 MSQFFSMAVKSKLNILLVGGTGSGKTTVMKAMVDEYPTDKRLFTIEDVHELDLPnHPNHLHLFYK-----QGGLTPKQII 233
Cdd:cd01130    1 MAAFLRLAVRARKNILISGGTGSGKTTLLNALLSFIPPDERIVTIEDTRELQLP-HPNVVHLLTRpgggeKGEVTMADLL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673 234 ESCMRMKPDHVLLAELRGDEAWTYLEMLNTGHEGSITTIHANDCYSTPARLAGLVKQSevGQTLDYHHIMRTIRTSIDVI 313
Cdd:cd01130   80 KAALRMRPDRIIVGEVRGGEAYDMLQAMNTGHPGSITTIHANSAEDAIDRLATLVLEA--GVNLDEEALRRLIASAIDVI 157

                        170       180
                 ....*....|....*....|
gi 500802673 314 AFFKHT-----HLVELFYDP 328
Cdd:cd01130  158 VHVKRLgdgvrRVTEIYEVP 177
PRK13900 PRK13900
type IV secretion system ATPase VirB11; Provisional
 26-319 7.41e-65

type IV secretion system ATPase VirB11; Provisional


Pssm-ID: 184381  Cd Length: 332  Bit Score: 208.07  E-value: 7.41e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673  26 EGLTEIAINRPNEVWFDRGNGWERDALPNLSLNMCSNLAKALATFAGLTIplGEANPVASVIFPDGERGQIAIPPATENG 105
Cdd:PRK13900  22 DGVNEISINKPGEVWVEKKGDIRCEQIPELDLSHLKALGRLVAQATEQKI--SEEKPLLSATLPNGYRIQIVFPPACEIG 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673 106 IVSMTIRKPSLTRFALSSYQESGRFSDFremdVNRVELTPVQEQLLTLKQNGDMSQFFSMAVKSKLNILLVGGTGSGKTT 185
Cdd:PRK13900 100 QIVYSIRKPSGMQLTLDDYEKMGAFDET----ATESLVDEDDVILNELLAEKKIKEFLEHAVISKKNIIISGGTSTGKTT 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673 186 VMKAMVDEYPTDKRLFTIEDVHELDLPNHPNHLHLFYKQGG-----LTPKQIIESCMRMKPDHVLLAELRGDEAWTYLEM 260
Cdd:PRK13900 176 FTNAALREIPAIERLITVEDAREIVLSNHPNRVHLLASKGGqgrakVTTQDLIEACLRLRPDRIIVGELRGAEAFSFLRA 255

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 500802673 261 LNTGHEGSITTIHANdcysTPA----RLAGLVKQSEVGQTLDyhHIMRTIRTSIDVIAFFKHT 319
Cdd:PRK13900 256 INTGHPGSISTLHAD----SPAmaieQLKLMVMQAGLGMPPD--QIKKYILNVVDIVVQLKRG 312
CpaF COG4962
Pilus assembly protein, ATPase of CpaF family [Intracellular trafficking, secretion, and ...
 1-313 1.37e-64

Pilus assembly protein, ATPase of CpaF family [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 443988 [Multi-domain]  Cd Length: 386  Bit Score: 208.87  E-value: 1.37e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673   1 MNTIDKAATVNQLL-SMTG---LRHYLDLEGLTEIAINRPNEVWFDRGNGWERDALPNLSLNMCSNLAKALATFAGltIP 76
Cdd:COG4962   37 LSDAEREALARAVLdELFGlgpLEPLLDDPDVTDIMVNGPDEVFVERGGRLERTDVRFDSEEELRRLIERIAARVG--RR 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673  77 LGEANPVASVIFPDGERGQIAIPPATENGiVSMTIRKPSLTRFALSSYQESGRFSDfremdvnrveltpvqeqlltlkqn 156
Cdd:COG4962  115 LDESSPIVDARLPDGSRVNAVIPPVARDG-PSLSIRKFRKRPLTLEDLVALGSLTP------------------------ 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673 157 gDMSQFFSMAVKSKLNILLVGGTGSGKTTVMKAMVDEYPTDKRLFTIEDVHELDLPnHPNHLHLFYKQ------GGLTPK 230
Cdd:COG4962  170 -EMAEFLRAAVRARLNILVSGGTGSGKTTLLNALSGFIPPDERIVTIEDAAELQLQ-HPHVVRLETRPpnvegaGEVTLR 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673 231 QIIESCMRMKPDHVLLAELRGDEAWTYLEMLNTGHEGSITTIHANDCYSTPARLAGLVKQSevGQTLDYHHIMRTIRTSI 310
Cdd:COG4962  248 DLVRNALRMRPDRIIVGEVRGAEALDMLQAMNTGHDGSMSTLHANSARDALARLETLALMA--GENLPREAVRRQIASAI 325


                 ...
gi 500802673 311 DVI 313
Cdd:COG4962  326 DLV 328
T2SSE pfam00437
Type II/IV secretion system protein; This family contains components of both the Type II ...
 26-288 1.80e-31

Type II/IV secretion system protein; This family contains components of both the Type II protein secretion system (T2SS), including Type 4 pilus (T4P), and Type IV protein secretion system (T4SS) from Gram-negative bacteria. VirB11 ATPase is a subunit of the Agrobacterium tumefaciens transfer DNA (T-DNA) transfer system, a type IV secretion pathway required for delivery of T-DNA and effector proteins to plant cells during infection. The cytoplasmic T2S E ATPase is a Zn-containing protein thought to provide the mechanical force for the secretion process. T2S-E contains Walker A and B motifs, that are essential for secretion and ATPase activity. ATPase PulE and XcpR from Klebsiella oxytoca and Pseudomonas aeruginosa respectively are required for protein secretion via the T2SS. ATPase PilB is required for T4P extension.


Pssm-ID: 425681 [Multi-domain]  Cd Length: 269  Bit Score: 119.31  E-value: 1.80e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673   26 EGLTEIAINRPNEVWF--DRGNGwERDALPNLSLNMCSNLAKALATFAGLTIplGEANP-----VASVIFPDGERGQIAI 98
Cdd:pfam00437  10 EGASDIHVEPPERIVWirFRVDG-VLREIPFPDADALARLISRIKVMARLDI--SERRPpqdgrLPLRIGGKGVRVRVST 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673   99 PPATENGIVSMTIRKPSLTRFALssyqesgrfsdfremdvnrveltpvQEQLLTLKQNGDMSQFFSmavKSKLNILLVGG 178
Cdd:pfam00437  87 LPTAGGEKLVIRLLDPSNVALSL-------------------------DELGMTGAQDEALLEFLR---QPRGNILVTGP 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673  179 TGSGKTTVMKAMVDEYPT-DKRLFTIEDVHELDLPnHPNHLHLfYKQGGLTPKQIIESCMRMKPDHVLLAELRGDE-AWT 256
Cdd:pfam00437 139 TGSGKTTTLYAALGELNTrDENIVTVEDPVEIQLE-GINQVQL-NARAGVTFADLLRAILRQDPDRIMVGEIRDLEtAEI 216

                         250       260       270
                  ....*....|....*....|....*....|..
gi 500802673  257 YLEMLNTGHEGsITTIHANDCYSTPARLAGLV 288
Cdd:pfam00437 217 ALQAANTGHLV-LSTLHTNSAAGALTRLQDMG 247
ATPase_ComGA NF041000
competence type IV pilus ATPase ComGA;
173-297 2.12e-09

competence type IV pilus ATPase ComGA;


Pssm-ID: 468930 [Multi-domain]  Cd Length: 265  Bit Score: 57.46  E-value: 2.12e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673 173 ILLVGGTGSGKTTVMKAMVDEYPTDKRLFTIEDVHELdlpNHPNHLHLfykQ----GGLTPKQIIESCMRMKPDHVLLAE 248
Cdd:NF041000 131 ILFSGPTGSGKTTTMYSLARKLALNKQVITIEDPVEI---KEPNFLQL---QvnekAGMTYDTLLKAALRHRPDILIIGE 204

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 500802673 249 LRgDE--AWTYLEMLNTGHEgSITTIHANDCYSTPARLAGL-VKQSEVGQTL 297
Cdd:NF041000 205 IR-DAetAKAAIRAALTGHL-VLSTVHAKSAAGVIYRLLELgISKEELEQTL 254
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 172-312 2.99e-05

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 43.52  E-value: 2.99e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673   172 NILLVGGTGSGKTTVMKAMVDEYPTDKRLF------TIEDVHELDLPNHPNHLHLFYKQGGLTPKQIIESCMRMKPDHVL 245
Cdd:smart00382   4 VILIVGPPGSGKTTLARALARELGPPGGGViyidgeDILEEVLDQLLLIIVGGKKASGSGELRLRLALALARKLKPDVLI 83

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 500802673   246 LaelrgDEAWTYLEMLNTGHEGSITTIHANDCYSTPARLAgLVKQSEVGQTLDYHHIMRTIRTSIDV 312
Cdd:smart00382  84 L-----DEITSLLDAEQEALLLLLEELRLLLLLKSEKNLT-VILTTNDEKDLGPALLRRRFDRRIVL 144
 
Name Accession Description Interval E-value
VirB11 TIGR02788
P-type DNA transfer ATPase VirB11; The VirB11 protein is found in the vir locus of ...
 22-326 3.33e-126

P-type DNA transfer ATPase VirB11; The VirB11 protein is found in the vir locus of Agrobacterium Ti plasmids where it is involved in the type IV secretion system for DNA transfer. VirB11 is believed to be an ATPase. VirB11 is a homolog of the P-like conjugation system TrbB protein and the Flp pilus sytem protein TadA.


Pssm-ID: 274301  Cd Length: 308  Bit Score: 363.98  E-value: 3.33e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673   22 YLDLEGLTEIAINRPNEVWFDRGNGWERDALPNLSLNMCSNLAKALATFAGLTIplGEANPVASVIFPDGERGQIAIPPA 101
Cdd:TIGR02788   1 FLDDEDVTEICINRPGEVWVEGPGGWQRFDVPDLTFSHLMRLARAIASFSKQSI--SEENPILSATLPGGERVQIVIPPA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673  102 TENGIVSMTIRKPSLTRFALSSYQESGRFSDFREmdvNRVELTPVQEQLLTLKQNGDMSQFFSMAVKSKLNILLVGGTGS 181
Cdd:TIGR02788  79 CENDTVSITIRKPSLVDFSLDDYEEKGFFDTVRA---QSGTLSDNDEQLLELLDAGDIKEFLRLAIASRKNIIISGGTGS 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673  182 GKTTVMKAMVDEYPTDKRLFTIEDVHELDLPnHPNHLHLFYKQGG-----LTPKQIIESCMRMKPDHVLLAELRGDEAWT 256
Cdd:TIGR02788 156 GKTTFLKSLVDEIPKDERIITIEDTREIFLP-HPNYVHLFYSKGGqglakVTPKDLLQSCLRMRPDRIILGELRGDEAFD 234

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 500802673  257 YLEMLNTGHEGSITTIHANDCYSTPARLAGLVKQSEVGQTLDYHHIMRTIRTSIDVIAFFKHT----HLVELFY 326
Cdd:TIGR02788 235 FIRAVNTGHPGSITTLHAGSPEEAFEQLALMVKSSQAGLGLDFAYIVKLVREVIDIVVQINRRgggrKITEVYF 308
VirB11-like_ATPase cd01130
Type IV secretory pathway component VirB11-like; Type IV secretory pathway component VirB11, ...
 159-328 1.20e-66

Type IV secretory pathway component VirB11-like; Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir (virulence) proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the bacterial Ti (tumor-inducing)-plasmid into plant cells. The pilus is a fibrous cell surface organelle, which mediates adhesion between bacteria during conjugative transfer or between bacteria and host eukaryotic cells during infection. VirB11-related ATPases include Sulfolobus acidocaldarius FlaI, which plays key roles in archaellum (archaeal flagellum) assembly and motility functions, and the pilus assembly proteins CpaF/TadA and TrbB. This alignment contains the C-terminal domain, which is the ATPase.


Pssm-ID: 410874 [Multi-domain]  Cd Length: 177  Bit Score: 207.39  E-value: 1.20e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673 159 MSQFFSMAVKSKLNILLVGGTGSGKTTVMKAMVDEYPTDKRLFTIEDVHELDLPnHPNHLHLFYK-----QGGLTPKQII 233
Cdd:cd01130    1 MAAFLRLAVRARKNILISGGTGSGKTTLLNALLSFIPPDERIVTIEDTRELQLP-HPNVVHLLTRpgggeKGEVTMADLL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673 234 ESCMRMKPDHVLLAELRGDEAWTYLEMLNTGHEGSITTIHANDCYSTPARLAGLVKQSevGQTLDYHHIMRTIRTSIDVI 313
Cdd:cd01130   80 KAALRMRPDRIIVGEVRGGEAYDMLQAMNTGHPGSITTIHANSAEDAIDRLATLVLEA--GVNLDEEALRRLIASAIDVI 157

                        170       180
                 ....*....|....*....|
gi 500802673 314 AFFKHT-----HLVELFYDP 328
Cdd:cd01130  158 VHVKRLgdgvrRVTEIYEVP 177
PRK13900 PRK13900
type IV secretion system ATPase VirB11; Provisional
 26-319 7.41e-65

type IV secretion system ATPase VirB11; Provisional


Pssm-ID: 184381  Cd Length: 332  Bit Score: 208.07  E-value: 7.41e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673  26 EGLTEIAINRPNEVWFDRGNGWERDALPNLSLNMCSNLAKALATFAGLTIplGEANPVASVIFPDGERGQIAIPPATENG 105
Cdd:PRK13900  22 DGVNEISINKPGEVWVEKKGDIRCEQIPELDLSHLKALGRLVAQATEQKI--SEEKPLLSATLPNGYRIQIVFPPACEIG 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673 106 IVSMTIRKPSLTRFALSSYQESGRFSDFremdVNRVELTPVQEQLLTLKQNGDMSQFFSMAVKSKLNILLVGGTGSGKTT 185
Cdd:PRK13900 100 QIVYSIRKPSGMQLTLDDYEKMGAFDET----ATESLVDEDDVILNELLAEKKIKEFLEHAVISKKNIIISGGTSTGKTT 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673 186 VMKAMVDEYPTDKRLFTIEDVHELDLPNHPNHLHLFYKQGG-----LTPKQIIESCMRMKPDHVLLAELRGDEAWTYLEM 260
Cdd:PRK13900 176 FTNAALREIPAIERLITVEDAREIVLSNHPNRVHLLASKGGqgrakVTTQDLIEACLRLRPDRIIVGELRGAEAFSFLRA 255

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 500802673 261 LNTGHEGSITTIHANdcysTPA----RLAGLVKQSEVGQTLDyhHIMRTIRTSIDVIAFFKHT 319
Cdd:PRK13900 256 INTGHPGSISTLHAD----SPAmaieQLKLMVMQAGLGMPPD--QIKKYILNVVDIVVQLKRG 312
CpaF COG4962
Pilus assembly protein, ATPase of CpaF family [Intracellular trafficking, secretion, and ...
 1-313 1.37e-64

Pilus assembly protein, ATPase of CpaF family [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 443988 [Multi-domain]  Cd Length: 386  Bit Score: 208.87  E-value: 1.37e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673   1 MNTIDKAATVNQLL-SMTG---LRHYLDLEGLTEIAINRPNEVWFDRGNGWERDALPNLSLNMCSNLAKALATFAGltIP 76
Cdd:COG4962   37 LSDAEREALARAVLdELFGlgpLEPLLDDPDVTDIMVNGPDEVFVERGGRLERTDVRFDSEEELRRLIERIAARVG--RR 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673  77 LGEANPVASVIFPDGERGQIAIPPATENGiVSMTIRKPSLTRFALSSYQESGRFSDfremdvnrveltpvqeqlltlkqn 156
Cdd:COG4962  115 LDESSPIVDARLPDGSRVNAVIPPVARDG-PSLSIRKFRKRPLTLEDLVALGSLTP------------------------ 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673 157 gDMSQFFSMAVKSKLNILLVGGTGSGKTTVMKAMVDEYPTDKRLFTIEDVHELDLPnHPNHLHLFYKQ------GGLTPK 230
Cdd:COG4962  170 -EMAEFLRAAVRARLNILVSGGTGSGKTTLLNALSGFIPPDERIVTIEDAAELQLQ-HPHVVRLETRPpnvegaGEVTLR 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673 231 QIIESCMRMKPDHVLLAELRGDEAWTYLEMLNTGHEGSITTIHANDCYSTPARLAGLVKQSevGQTLDYHHIMRTIRTSI 310
Cdd:COG4962  248 DLVRNALRMRPDRIIVGEVRGAEALDMLQAMNTGHDGSMSTLHANSARDALARLETLALMA--GENLPREAVRRQIASAI 325


                 ...
gi 500802673 311 DVI 313
Cdd:COG4962  326 DLV 328
PRK13851 PRK13851
type IV secretion system protein VirB11; Provisional
 22-317 3.14e-64

type IV secretion system protein VirB11; Provisional


Pssm-ID: 172375  Cd Length: 344  Bit Score: 207.06  E-value: 3.14e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673  22 YLDLEGLTEIAINRPNEVWFDRGNGWERDALPnLSLNMCSNLAkalaTFAGL--TIPLGEANPVASVIFPDGERGQIAIP 99
Cdd:PRK13851  17 WLDDPRTEEVAINRPGEAFVRQAGVFTKFPLP-LSYDDLEDIA----ILAGAlrKQDVGPRNPLCATELPGGERLQICLP 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673 100 PATENGIVSMTIRKPSLTRFAL---SSYQESGRFSDFREmdvNRVELTPVQEQLLTLKQNGDMSQFFSMAVKSKLNILLV 176
Cdd:PRK13851  92 PTVPSGTVSLTIRRPSSRVSELkevSSRYDASRWNQWQE---RRKRRDQLDEAILRHYDNGDLEAFLHACVVGRLTMLLC 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673 177 GGTGSGKTTVMKAMVDEYPTDKRLFTIEDVHELDLPnHPNHLHLFYKQ-----GGLTPKQIIESCMRMKPDHVLLAELRG 251
Cdd:PRK13851 169 GPTGSGKTTMSKTLISAIPPQERLITIEDTLELVIP-HENHVRLLYSKngaglGAVTAEHLLQASLRMRPDRILLGEMRD 247

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 500802673 252 DEAWTYLEMLNTGHEGSITTIHANDCYSTPARLAGLVKQSEVGQTLDYHHIMRTIRTSIDVIAFFK 317
Cdd:PRK13851 248 DAAWAYLSEVVSGHPGSISTIHGANPVQGFKKLFSLVKSSAQGASLEDRTLIDMLATAIDVIVPFR 313
heli_sec_ATPase TIGR03819
helicase/secretion neighborhood ATPase; Members of this protein family comprise a distinct ...
 19-287 1.84e-44

helicase/secretion neighborhood ATPase; Members of this protein family comprise a distinct clade of putative ATPase associated with an integral membrane complex likely to act in pilus formation, secretion, or conjugal transfer. The association of most members with a nearby gene for a DEAH-box helicase suggests a role in conjugal transfer.


Pssm-ID: 200328  Cd Length: 340  Bit Score: 155.18  E-value: 1.84e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673   19 LRHYLDLEGLTEIAINRPNEVWFDRGNGWERDALPNLSLNMCSNLAKALATFAGLTipLGEANPVASVIFPDGERGQIAI 98
Cdd:TIGR03819  55 LEPLLADPGVTDVLVNGPDEVWVDRGRGLERTDVRFPDEAAVRRLAQRLAAAAGRR--LDDAQPWVDARLPDGTRLHAVL 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673   99 PPATENGIVsMTIRKPSLTRFALSSYQESGRFsdfremdvnrvelTPVQEQLLtlkqngdmsqffSMAVKSKLNILLVGG 178
Cdd:TIGR03819 133 PPVATDGTC-LSLRVPRRRTFTLDELVAAGTI-------------PPGVARLL------------RALVAARLAFLVSGG 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673  179 TGSGKTTVMKAMVDEYPTDKRLFTIEDVHELdLPNHPNHLHLFYKQ------GGLTPKQIIESCMRMKPDHVLLAELRGD 252
Cdd:TIGR03819 187 TGSGKTTLLSALLALVPPDERIVLVEDAAEL-RPDHPHVVRLEARPanvegaGAVTLTDLVRQALRMRPDRIVVGEVRGA 265

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 500802673  253 EAWTYLEMLNTGHEGSITTIHANDCYSTPARLAGL 287
Cdd:TIGR03819 266 EVVDLLAALNTGHDGGAGTLHANSPADVPARLEAL 300
TrbB_P TIGR02782
P-type conjugative transfer ATPase TrbB; The TrbB protein is found in the trb locus of ...
 22-319 6.32e-39

P-type conjugative transfer ATPase TrbB; The TrbB protein is found in the trb locus of Agrobacterium Ti plasmids where it is involved in the type IV secretion system for plasmid conjugative transfer. TrbB is a homolog of the vir system VirB11 ATPase, and the Flp pilus sytem ATPase TadA. [Cellular processes, Conjugation]


Pssm-ID: 274297  Cd Length: 299  Bit Score: 139.88  E-value: 6.32e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673   22 YLDLEGLTEIAINRPNEVWFDRGNGWERDAlPNLSLNMCSNLAKALATFAGLTIplGEANPVASVIFP-DGERGQIAIPP 100
Cdd:TIGR02782  13 ALDDPGVVEIMLNPDGRLWVERLGSGMSPL-GEMSPADAQRIIGLVADYLGTEV--DRDKPIVEGELPlDGSRFEGLIPP 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673  101 ATENgiVSMTIRKPSLTRFALSSYQESGrfsdfremdvnrveltpvqeqLLTLKQNGDMSQffsmAVKSKLNILLVGGTG 180
Cdd:TIGR02782  90 VVAA--PSFAIRKKAVAVFTLDDYVEAG---------------------IMTAAQRDVLRE----AVLARKNILVVGGTG 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673  181 SGKTTVMKAMVDE----YPTDkRLFTIEDVHELDLpNHPNHLHLFYKQGGLTPKQIIESCMRMKPDHVLLAELRGDEAWT 256
Cdd:TIGR02782 143 SGKTTLANALLAEiaknDPTD-RVVIIEDTRELQC-AAPNVVQLRTSDDAISMTRLLKATLRLRPDRIIVGEVRGGEALD 220

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 500802673  257 YLEMLNTGHEGSITTIHANDCYSTPARLAGLVkqSEVGQTLdyhhIMRTIRTSIDVIAFFKHT 319
Cdd:TIGR02782 221 LLKAWNTGHPGGIATIHANNAKAALDRLEQLI--QEVSVTP----MQTLIAEAVDLVIFIART 277
T2SSE pfam00437
Type II/IV secretion system protein; This family contains components of both the Type II ...
 26-288 1.80e-31

Type II/IV secretion system protein; This family contains components of both the Type II protein secretion system (T2SS), including Type 4 pilus (T4P), and Type IV protein secretion system (T4SS) from Gram-negative bacteria. VirB11 ATPase is a subunit of the Agrobacterium tumefaciens transfer DNA (T-DNA) transfer system, a type IV secretion pathway required for delivery of T-DNA and effector proteins to plant cells during infection. The cytoplasmic T2S E ATPase is a Zn-containing protein thought to provide the mechanical force for the secretion process. T2S-E contains Walker A and B motifs, that are essential for secretion and ATPase activity. ATPase PulE and XcpR from Klebsiella oxytoca and Pseudomonas aeruginosa respectively are required for protein secretion via the T2SS. ATPase PilB is required for T4P extension.


Pssm-ID: 425681 [Multi-domain]  Cd Length: 269  Bit Score: 119.31  E-value: 1.80e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673   26 EGLTEIAINRPNEVWF--DRGNGwERDALPNLSLNMCSNLAKALATFAGLTIplGEANP-----VASVIFPDGERGQIAI 98
Cdd:pfam00437  10 EGASDIHVEPPERIVWirFRVDG-VLREIPFPDADALARLISRIKVMARLDI--SERRPpqdgrLPLRIGGKGVRVRVST 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673   99 PPATENGIVSMTIRKPSLTRFALssyqesgrfsdfremdvnrveltpvQEQLLTLKQNGDMSQFFSmavKSKLNILLVGG 178
Cdd:pfam00437  87 LPTAGGEKLVIRLLDPSNVALSL-------------------------DELGMTGAQDEALLEFLR---QPRGNILVTGP 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673  179 TGSGKTTVMKAMVDEYPT-DKRLFTIEDVHELDLPnHPNHLHLfYKQGGLTPKQIIESCMRMKPDHVLLAELRGDE-AWT 256
Cdd:pfam00437 139 TGSGKTTTLYAALGELNTrDENIVTVEDPVEIQLE-GINQVQL-NARAGVTFADLLRAILRQDPDRIMVGEIRDLEtAEI 216

                         250       260       270
                  ....*....|....*....|....*....|..
gi 500802673  257 YLEMLNTGHEGsITTIHANDCYSTPARLAGLV 288
Cdd:pfam00437 217 ALQAANTGHLV-LSTLHTNSAAGALTRLQDMG 247
PRK13894 PRK13894
conjugal transfer ATPase TrbB; Provisional
 30-288 4.65e-30

conjugal transfer ATPase TrbB; Provisional


Pssm-ID: 184377  Cd Length: 319  Bit Score: 116.76  E-value: 4.65e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673  30 EIAINRPNEVWFDRgNGWERDALPNLSLNMCSNLAKALATFAGLTI----PLGEANpvasviFP-DGER--GQIaiPPAT 102
Cdd:PRK13894  37 EIMLNADGKLWQER-LGEPMRCIGTLRVAQAQAIIETIAGYHGKEVtrskPILEGE------LPlDGSRfaGQL--PPVV 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673 103 ENGivSMTIRKPSLTRFALSSYQESGRfsdfremdvnrveLTPVQEQLLTlkqngdmsqffsMAVKSKLNILLVGGTGSG 182
Cdd:PRK13894 108 PAP--TFAIRKKAVAIFTLDQYVERGI-------------MTAAQREAII------------AAVRAHRNILVIGGTGSG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673 183 KTTVMKA----MVDEYPTDkRLFTIEDVHELDLPNHpNHLHlFYKQGGLTPKQIIESCMRMKPDHVLLAELRGDEAWTYL 258
Cdd:PRK13894 161 KTTLVNAiineMVIQDPTE-RVFIIEDTGEIQCAAE-NYVQ-YHTSIDVNMTALLKTTLRMRPDRILVGEVRGPEALDLL 237

                        250       260       270
                 ....*....|....*....|....*....|
gi 500802673 259 EMLNTGHEGSITTIHANDCYSTPARLAGLV 288
Cdd:PRK13894 238 MAWNTGHEGGAATLHANNAKAGLDRLKSLI 267
VirB11 COG0630
Type IV secretory pathway ATPase VirB11/Archaellum biosynthesis ATPase ArlI/FlaI [Cell ...
 80-319 5.86e-29

Type IV secretory pathway ATPase VirB11/Archaellum biosynthesis ATPase ArlI/FlaI [Cell motility, Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440395 [Multi-domain]  Cd Length: 462  Bit Score: 115.95  E-value: 5.86e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673  80 ANPVASVIFPDGERGQIAIPPA-TENGiVSMTIRKpsltrfalssyqesgrfsdFREMDvnrveLTPVQeqLLTLKQ-NG 157
Cdd:COG0630  225 ARPIVDATLPDGSRIALTLGPEvSRRG-SSFTIRK-------------------FREVP-----LTPID--LIEWGTlSP 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673 158 DMSQFFSMAVKSKLNILLVGGTGSGKTTVMKAMVDEYPTDKRLFTIEDVHELDLPnHPNHLHLFYKQGGLTPKQII---- 233
Cdd:COG0630  278 ELAAYLWLLLENGKSVLVAGGTASGKTTLLNALLSFIPPDAKIVTIEDTRELNLP-HENWISLVTRESFGGEEGDVtmfd 356

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673 234 --ESCMRMKPDHVLLAELRGDEAWTYLEMLNTGHeGSITTIHANDCYSTPARLaglvkqsevgqTLDYHHIMRTIRTSID 311
Cdd:COG0630  357 llKAALRQRPDYIVVGEVRGEEAYTLFQAMATGH-GVLSTFHADSVESAINRL-----------TSPPINVPRTLLQALD 424


                 ....*...
gi 500802673 312 VIAFFKHT 319
Cdd:COG0630  425 LVVFQKRV 432
type_II_IV_secretion_ATPases cd19477
type II/type IV hexameric secretion ATPases; RecA-like NTPases. This family includes the NTP ...
 163-326 1.79e-28

type II/type IV hexameric secretion ATPases; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410885 [Multi-domain]  Cd Length: 168  Bit Score: 108.25  E-value: 1.79e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673 163 FSMAVKSKLNILLVGGTGSGKTTVMKAMVDEYPTDKRLFTIEDVHELDLPNHPNHLHLFYkQGGLTPKQIIESCMRMKPD 242
Cdd:cd19477    3 IKDGIAIGKNVIVCGGTGSGKTTYIKSILEFIPKEERIISIEDTEEIVFKHHKNYTQLFF-GGNITSADCLKSCLRQRPD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673 243 HVLLAELRGDEAWTYLEMLNTGHEGSITTIHANDCYSTPARLAGLVKQSEVGQTLDYHHIMRTIRTSIDVIAFFKHTHLV 322
Cdd:cd19477   82 RIILGELRSSEAYDFYNVLCSGHKGTLTTLHAGSSEEAFIRLAN*SSSNSAARNIKFESLIEGFKDLIDGIVHINHHKQC 161


                 ....
gi 500802673 323 ELFY 326
Cdd:cd19477  162 DEFY 165
PRK13833 PRK13833
conjugal transfer protein TrbB; Provisional
 91-295 2.31e-19

conjugal transfer protein TrbB; Provisional


Pssm-ID: 172360 [Multi-domain]  Cd Length: 323  Bit Score: 87.16  E-value: 2.31e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673  91 GERGQIAIPPATenGIVSMTIRKPSLTRFALSSYQESGRFSdfremdvnrveltpvQEQLLTLKQngdmsqffsmAVKSK 170
Cdd:PRK13833  92 GHRFEGLLPPVV--SGPAFTIRRRASRLIPLDDYVTSKIMT---------------EAQASVIRS----------AIDSR 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673 171 LNILLVGGTGSGKTT----VMKAMVDEYPTDkRLFTIEDVHELDLPNHpNHLHLfYKQGGLTPKQIIESCMRMKPDHVLL 246
Cdd:PRK13833 145 LNIVISGGTGSGKTTlanaVIAEIVASAPED-RLVILEDTAEIQCAAE-NAVAL-HTSDTVDMARLLKSTMRLRPDRIIV 221

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 500802673 247 AELRGDEAWTYLEMLNTGHEGSITTIHANDCYSTPARLAGLVkqSEVGQ 295
Cdd:PRK13833 222 GEVRDGAALTLLKAWNTGHPGGVTTIHSNTAMSALRRLEQLT--AEASQ 268
PulE-GspE-like cd01129
PulE-GspE family; PulE and General secretory pathway protein GspE are ATPases of the type II ...
 173-287 3.97e-13

PulE-GspE family; PulE and General secretory pathway protein GspE are ATPases of the type II secretory pathway, the main terminal branch of the general secretory pathway (GSP). PulE is a cytoplasmic protein of the GSP, which contains an ATP binding site and a tetracysteine motif. This subgroup also includes PilB, a type IV pilus assembly ATPase, DotB, an ATPase of the type IVb secretion system, also known as the dot/icm system, Escherichia coli IncI plasmid-encoded conjugative transfer ATPase TraJ, and HofB.


Pssm-ID: 410873 [Multi-domain]  Cd Length: 159  Bit Score: 66.36  E-value: 3.97e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673 173 ILLVGGTGSGKTTVMKAMVDEYPT-DKRLFTIEDVHELDLPNhPNHLHLFyKQGGLTPKQIIESCMRMKPDHVLLAELR- 250
Cdd:cd01129   14 ILVTGPTGSGKTTTLYAMLRELNGpERNIITIEDPVEYQIPG-INQSQVN-EKIGLTFADALRAILRQDPDIIMVGEIRd 91

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 500802673 251 GDEAWTYLEMLNTGHEgSITTIHANDCYSTPARLAGL 287
Cdd:cd01129   92 AETAEIAIRAALTGHL-VLSTLHTNDALGAITRLLDM 127
DotB_TraJ cd19516
dot/icm secretion system protein DotB-like; Defect in organelle trafficking (Dot)B is part of ...
 170-307 5.54e-11

dot/icm secretion system protein DotB-like; Defect in organelle trafficking (Dot)B is part of the type IVb secretion (T4bS) system, also known as the dot/icm system, and is the main energy supplier of the secretion system. It is an ATPase, similar to the VirB11 component of the T4aS systems. This family also includes Escherichia coli IncI plasmid-encoded conjugative transfer ATPase TraJ encoded on the tra (transfer) operon.


Pssm-ID: 410924 [Multi-domain]  Cd Length: 179  Bit Score: 60.47  E-value: 5.54e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673 170 KLNILLVGG-TGSGKTTVMKAMV----DEYPTDKRLFTIEDVHE--LDLPNH----------PNHLHLFYKQggltpkqi 232
Cdd:cd19516   10 REGLVYVAGaTGSGKSTLLAAIYryilENDPPDRKIITYEDPIEfvYDGIKSkhsiivqsqiPRHFKSFAKA-------- 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 500802673 233 IESCMRMKPDHVLLAELRGDEAW-TYLEMLNTGHEgSITTIHANDCYSTPARLAGLVKQSEVGQTLdyHHIMRTIR 307
Cdd:cd19516   82 VREALRRKPSLIGVGELRDQETIsAAVEASLTGHP-VYSTVHTKSVAETIRRLISLFPPEERDAAA--YDLLSTLR 154
ATPase_ComGA NF041000
competence type IV pilus ATPase ComGA;
173-297 2.12e-09

competence type IV pilus ATPase ComGA;


Pssm-ID: 468930 [Multi-domain]  Cd Length: 265  Bit Score: 57.46  E-value: 2.12e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673 173 ILLVGGTGSGKTTVMKAMVDEYPTDKRLFTIEDVHELdlpNHPNHLHLfykQ----GGLTPKQIIESCMRMKPDHVLLAE 248
Cdd:NF041000 131 ILFSGPTGSGKTTTMYSLARKLALNKQVITIEDPVEI---KEPNFLQL---QvnekAGMTYDTLLKAALRHRPDILIIGE 204

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 500802673 249 LRgDE--AWTYLEMLNTGHEgSITTIHANDCYSTPARLAGL-VKQSEVGQTL 297
Cdd:NF041000 205 IR-DAetAKAAIRAALTGHL-VLSTVHAKSAAGVIYRLLELgISKEELEQTL 254
PilT cd01131
Pilus retraction ATPase PilT; Pilus retraction ATPase PilT is a nucleotide-binding protein ...
 173-288 1.91e-07

Pilus retraction ATPase PilT; Pilus retraction ATPase PilT is a nucleotide-binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism known as twitching motility.


Pssm-ID: 410875 [Multi-domain]  Cd Length: 223  Bit Score: 51.00  E-value: 1.91e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673 173 ILLVGGTGSGKTTVMKAMVDEYPTDKRL--FTIED----VHELD--LPNHPN---HLHLFYKqgGLTpkqiieSCMRMKP 241
Cdd:cd01131   24 VLVTGPTGSGKSTTLAAMIDYINETRSKhiITIEDpiefVHKHKksLINQREvgrDTESFAA--ALR------AALREDP 95

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 500802673 242 DHVLLAELRGDEAWTY-LEMLNTGHEgSITTIHANDCYSTPARLAGLV 288
Cdd:cd01131   96 DVILVGEMRDLETIELaLTAAETGHL-VFSTLHTNSAAQTIDRIIDVF 142
PilT COG2805
Type IV pilus assembly protein PilT, pilus retraction ATPase [Cell motility, Extracellular ...
 173-284 5.61e-06

Type IV pilus assembly protein PilT, pilus retraction ATPase [Cell motility, Extracellular structures];


Pssm-ID: 442056  Cd Length: 342  Bit Score: 47.39  E-value: 5.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673 173 ILLVGGTGSGKTTVMKAMVDEYPTDKRLF--TIED----VHELD--LPNH---PNHLHLFYKqgGLtpkqiiESCMRMKP 241
Cdd:COG2805  128 VLVTGPTGSGKSTTLAAMIDYINETRAKHiiTIEDpiefVHKHKksLINQrevGRDTPSFAN--AL------RAALREDP 199

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 500802673 242 DHVLLAELRGDE----AwtyLEMLNTGHegsITTIHANDCYSTPARL 284
Cdd:COG2805  200 DVILVGEMRDLEtieaA---LTAAETGHl-vFATLHTNSAAQTIDRI 242
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 172-312 2.99e-05

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 43.52  E-value: 2.99e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500802673   172 NILLVGGTGSGKTTVMKAMVDEYPTDKRLF------TIEDVHELDLPNHPNHLHLFYKQGGLTPKQIIESCMRMKPDHVL 245
Cdd:smart00382   4 VILIVGPPGSGKTTLARALARELGPPGGGViyidgeDILEEVLDQLLLIIVGGKKASGSGELRLRLALALARKLKPDVLI 83

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 500802673   246 LaelrgDEAWTYLEMLNTGHEGSITTIHANDCYSTPARLAgLVKQSEVGQTLDYHHIMRTIRTSIDV 312
Cdd:smart00382  84 L-----DEITSLLDAEQEALLLLLEELRLLLLLKSEKNLT-VILTTNDEKDLGPALLRRRFDRRIVL 144
AAA_7 pfam12775
P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 ...
 162-198 3.96e-04

P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the third nucleotide binding sites in the dynein motor. However, AAA3 has lost the catalytic residues necessary for ATP hydrolysis (the Walker B glutamate, the arginine finger, sensor-I and sensor-II motifs).


Pssm-ID: 463698 [Multi-domain]  Cd Length: 179  Bit Score: 40.45  E-value: 3.96e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 500802673  162 FFSMAVKSKLNILLVGGTGSGKTTVMKAMVDEYPTDK 198
Cdd:pfam12775  23 LLDLLLKNGKPVLLVGPTGTGKTVIIQNLLRKLDKEK 59
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 168-209 4.81e-03

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 37.13  E-value: 4.81e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 500802673 168 KSKLNILLVGGTGSGKTTVMKAMVDEYPTDKRLFTIEDVHEL 209
Cdd:cd00009   17 PPPKNLLLYGPPGTGKTTLARAIANELFRPGAPFLYLNASDL 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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