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Conserved domains on  [gi|500639161|ref|WP_011962457|]
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T9SS type A sorting domain-containing protein [Flavobacterium psychrophilum]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Por_Secre_tail super family cl46851
Secretion system C-terminal sorting domain; Species that include Porphyromonas gingivalis, ...
 694-769 2.34e-08

Secretion system C-terminal sorting domain; Species that include Porphyromonas gingivalis, Fibrobacter succinogenes, Flavobacterium johnsoniae, Cytophaga hutchinsonii, Gramella forsetii, Prevotella intermedia, and Salinibacter ruber have on average twenty or more copies of this C-terminal domain, associated with sorting to the outer membrane and covalent modification. This domain targets proteins to type IX secretion systems and is secreted then cleaved off by a C-terminal signal peptidease. Based on similarity to other families it is likely that this domain adopts an immunoglobulin like fold.


The actual alignment was detected with superfamily member pfam18962:

Pssm-ID: 481191 [Multi-domain]  Cd Length: 75  Bit Score: 51.46  E-value: 2.34e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 500639161  694 IYPNPSNDIVNIEIrdaNNIPEKRATItgELFDMMRQL--KAKVEINNNKATFSVSGLNKGIYVLKIYINDKVESHQI 769
Cdd:pfam18962   1 IYPNPAKDVLNISL---KNSNSSNLNI--SIYDILGKLvkSNSKTNGNNTKTIDVSNLSSGIYFVKINSGNGSTTKKL 73
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 124-215 4.62e-08

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


:

Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 51.75  E-value: 4.62e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500639161 124 SLVEKLRSApyGFDVTLVNFPNGADYVERNAMALVSLLsreNAKLATNGsTEKISIIGPSMGGLVSRYALAYMEKNG-IN 202
Cdd:COG1075   23 PLAPRLRAA--GYPVYALNYPSTNGSIEDSAEQLAAFV---DAVLAATG-AEKVDLVGHSMGGLVARYYLKRLGGAAkVA 96

                         90
                 ....*....|...
gi 500639161 203 HntklWVSFDSPH 215
Cdd:COG1075   97 R----VVTLGTPH 105
 
Name Accession Description Interval E-value
Por_Secre_tail pfam18962
Secretion system C-terminal sorting domain; Species that include Porphyromonas gingivalis, ...
 694-769 2.34e-08

Secretion system C-terminal sorting domain; Species that include Porphyromonas gingivalis, Fibrobacter succinogenes, Flavobacterium johnsoniae, Cytophaga hutchinsonii, Gramella forsetii, Prevotella intermedia, and Salinibacter ruber have on average twenty or more copies of this C-terminal domain, associated with sorting to the outer membrane and covalent modification. This domain targets proteins to type IX secretion systems and is secreted then cleaved off by a C-terminal signal peptidease. Based on similarity to other families it is likely that this domain adopts an immunoglobulin like fold.


Pssm-ID: 436869 [Multi-domain]  Cd Length: 75  Bit Score: 51.46  E-value: 2.34e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 500639161  694 IYPNPSNDIVNIEIrdaNNIPEKRATItgELFDMMRQL--KAKVEINNNKATFSVSGLNKGIYVLKIYINDKVESHQI 769
Cdd:pfam18962   1 IYPNPAKDVLNISL---KNSNSSNLNI--SIYDILGKLvkSNSKTNGNNTKTIDVSNLSSGIYFVKINSGNGSTTKKL 73
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 124-215 4.62e-08

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 51.75  E-value: 4.62e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500639161 124 SLVEKLRSApyGFDVTLVNFPNGADYVERNAMALVSLLsreNAKLATNGsTEKISIIGPSMGGLVSRYALAYMEKNG-IN 202
Cdd:COG1075   23 PLAPRLRAA--GYPVYALNYPSTNGSIEDSAEQLAAFV---DAVLAATG-AEKVDLVGHSMGGLVARYYLKRLGGAAkVA 96

                         90
                 ....*....|...
gi 500639161 203 HntklWVSFDSPH 215
Cdd:COG1075   97 R----VVTLGTPH 105
Por_Secre_tail TIGR04183
Por secretion system C-terminal sorting domain; Species that include Porphyromonas gingivalis, ...
 694-772 7.29e-08

Por secretion system C-terminal sorting domain; Species that include Porphyromonas gingivalis, Fibrobacter succinogenes, Flavobacterium johnsoniae, Cytophaga hutchinsonii, Gramella forsetii, Prevotella intermedia, and Salinibacter ruber average twenty or more copies of a C-terminal domain, represented by this model, associated with sorting to the outer membrane and covalent modification.


Pssm-ID: 275036 [Multi-domain]  Cd Length: 72  Bit Score: 50.10  E-value: 7.29e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 500639161  694 IYPNPSNDIVNIEIRDANNIpekrATItgELFDMMRQLKaKVEINNNKATFSVSGLNKGIYVLKIYINDKVESHQIAVE 772
Cdd:TIGR04183   1 IYPNPAKGTLIIILLSSSGK----VKV--EIYDLSGKLV-KKTTLNNSNSIDLSNLSSGVYIVKITTGNGTITKKIIKK 72
T9SSA_dep_M36 NF038113
T9SS-dependent M36 family metallopeptidase; Members of this family have an M36 family ...
 688-772 5.94e-07

T9SS-dependent M36 family metallopeptidase; Members of this family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal T9SS type A sorting domain (see TIGR04131).


Pssm-ID: 468356 [Multi-domain]  Cd Length: 868  Bit Score: 53.12  E-value: 5.94e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500639161 688 NTNFYTIYPNPSNDIVNIeirDANNIPEKRATItgELFDMM-RQLKAKVEINNNKATFSVSGLNKGIYVLKIYINDKVES 766
Cdd:NF038113 788 GANKFIIYPNPAKGEIFI---SFSNKDSGEVKV--KVYDINgRLVLSDKVELTNTKTINTSGLQSGIYIVKIEGGSKSYT 862


                 ....*.
gi 500639161 767 HQIAVE 772
Cdd:NF038113 863 EKLIVK 868
DUF676 pfam05057
Putative serine esterase (DUF676); This family of proteins are probably serine esterase type ...
 173-217 7.15e-04

Putative serine esterase (DUF676); This family of proteins are probably serine esterase type enzymes with an alpha/beta hydrolase fold.


Pssm-ID: 309968  Cd Length: 212  Bit Score: 41.71  E-value: 7.15e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 500639161  173 STEKISIIGPSMGGLVSRYALAY-----MEKNGINHNTKL--WVSFDSPHLG 217
Cdd:pfam05057  73 DGKKISFVGHSLGGLIARYAIGKlydkaMTFKGFFKGLEPmnFITLASPHLG 124
 
Name Accession Description Interval E-value
Por_Secre_tail pfam18962
Secretion system C-terminal sorting domain; Species that include Porphyromonas gingivalis, ...
 694-769 2.34e-08

Secretion system C-terminal sorting domain; Species that include Porphyromonas gingivalis, Fibrobacter succinogenes, Flavobacterium johnsoniae, Cytophaga hutchinsonii, Gramella forsetii, Prevotella intermedia, and Salinibacter ruber have on average twenty or more copies of this C-terminal domain, associated with sorting to the outer membrane and covalent modification. This domain targets proteins to type IX secretion systems and is secreted then cleaved off by a C-terminal signal peptidease. Based on similarity to other families it is likely that this domain adopts an immunoglobulin like fold.


Pssm-ID: 436869 [Multi-domain]  Cd Length: 75  Bit Score: 51.46  E-value: 2.34e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 500639161  694 IYPNPSNDIVNIEIrdaNNIPEKRATItgELFDMMRQL--KAKVEINNNKATFSVSGLNKGIYVLKIYINDKVESHQI 769
Cdd:pfam18962   1 IYPNPAKDVLNISL---KNSNSSNLNI--SIYDILGKLvkSNSKTNGNNTKTIDVSNLSSGIYFVKINSGNGSTTKKL 73
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 124-215 4.62e-08

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 51.75  E-value: 4.62e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500639161 124 SLVEKLRSApyGFDVTLVNFPNGADYVERNAMALVSLLsreNAKLATNGsTEKISIIGPSMGGLVSRYALAYMEKNG-IN 202
Cdd:COG1075   23 PLAPRLRAA--GYPVYALNYPSTNGSIEDSAEQLAAFV---DAVLAATG-AEKVDLVGHSMGGLVARYYLKRLGGAAkVA 96

                         90
                 ....*....|...
gi 500639161 203 HntklWVSFDSPH 215
Cdd:COG1075   97 R----VVTLGTPH 105
Por_Secre_tail TIGR04183
Por secretion system C-terminal sorting domain; Species that include Porphyromonas gingivalis, ...
 694-772 7.29e-08

Por secretion system C-terminal sorting domain; Species that include Porphyromonas gingivalis, Fibrobacter succinogenes, Flavobacterium johnsoniae, Cytophaga hutchinsonii, Gramella forsetii, Prevotella intermedia, and Salinibacter ruber average twenty or more copies of a C-terminal domain, represented by this model, associated with sorting to the outer membrane and covalent modification.


Pssm-ID: 275036 [Multi-domain]  Cd Length: 72  Bit Score: 50.10  E-value: 7.29e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 500639161  694 IYPNPSNDIVNIEIRDANNIpekrATItgELFDMMRQLKaKVEINNNKATFSVSGLNKGIYVLKIYINDKVESHQIAVE 772
Cdd:TIGR04183   1 IYPNPAKGTLIIILLSSSGK----VKV--EIYDLSGKLV-KKTTLNNSNSIDLSNLSSGVYIVKITTGNGTITKKIIKK 72
T9SSA_dep_M36 NF038113
T9SS-dependent M36 family metallopeptidase; Members of this family have an M36 family ...
 688-772 5.94e-07

T9SS-dependent M36 family metallopeptidase; Members of this family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal T9SS type A sorting domain (see TIGR04131).


Pssm-ID: 468356 [Multi-domain]  Cd Length: 868  Bit Score: 53.12  E-value: 5.94e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500639161 688 NTNFYTIYPNPSNDIVNIeirDANNIPEKRATItgELFDMM-RQLKAKVEINNNKATFSVSGLNKGIYVLKIYINDKVES 766
Cdd:NF038113 788 GANKFIIYPNPAKGEIFI---SFSNKDSGEVKV--KVYDINgRLVLSDKVELTNTKTINTSGLQSGIYIVKIEGGSKSYT 862


                 ....*.
gi 500639161 767 HQIAVE 772
Cdd:NF038113 863 EKLIVK 868
DUF676 pfam05057
Putative serine esterase (DUF676); This family of proteins are probably serine esterase type ...
 173-217 7.15e-04

Putative serine esterase (DUF676); This family of proteins are probably serine esterase type enzymes with an alpha/beta hydrolase fold.


Pssm-ID: 309968  Cd Length: 212  Bit Score: 41.71  E-value: 7.15e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 500639161  173 STEKISIIGPSMGGLVSRYALAY-----MEKNGINHNTKL--WVSFDSPHLG 217
Cdd:pfam05057  73 DGKKISFVGHSLGGLIARYAIGKlydkaMTFKGFFKGLEPmnFITLASPHLG 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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