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Conserved domains on  [gi|500212820|ref|WP_011883000|]
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MULTISPECIES: DNA-directed RNA polymerase subunit beta [Burkholderia]

Protein Classification

DNA-directed RNA polymerase subunit beta( domain architecture ID 11478603)

DNA-directed RNA polymerase subunit beta catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
rpoB PRK00405
DNA-directed RNA polymerase subunit beta; Reviewed
1-1365 0e+00

DNA-directed RNA polymerase subunit beta; Reviewed


:

Pssm-ID: 234749 [Multi-domain]  Cd Length: 1112  Bit Score: 2187.57  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820    1 MQYSFTEKKRIRKSFAKRPIVHQVPFLLATQLESFSTFLQADVPATQrkpEGLQAAFTSVFPIVSHNGFARLEFVSYALS 80
Cdd:PRK00405    1 MVYSYTGKKRIRKSFGKIKEVLELPNLLEIQLDSFDWFLQLDVPPED---EGLEEVFRSIFPIEDFNGNLSLEFVSYELG 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   81 SPAFNIKECQQRGLTYCSALRAKVRLVILDkespnkpvVKEVKEQEVYMGEIPLMTPTGSFVINGTERVIVSQLHRSPGV 160
Cdd:PRK00405   78 EPKYDVEECKERGLTYSAPLRVKLRLINKE--------TGEIKEQEVYMGDIPLMTENGTFIINGTERVIVSQLHRSPGV 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  161 FFEHDKGKThSSGKLLFSARIIPYRGSWLDFEFDPKDILYFRVDRRRKMPVTILLKAIGLTPEQILANFFVFDNFTlmde 240
Cdd:PRK00405  150 YFDHDKDKT-SSGKLLYSARIIPYRGSWLEFEFDPKDILYVRIDRRRKLPVTVLLRALGYSDEEILDLFYEKEEFG---- 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  241 gaqlefvperlrgevarfditdrdgkvivqkdkrinakhirdleaaktKFISVPEDYLLGRVLAKNVVDGDTGEVIASAN 320
Cdd:PRK00405  225 ------------------------------------------------KEIEVPVEYLLGKVLAEDIVDEETGEVLAEAN 256
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  321 DEVTESVleklreagikdiqtlytndldQGPYISSTLRVDETTDRTAARIAIYRMMRPGEPPTEEAVEALFNRLFYSEEA 400
Cdd:PRK00405  257 DEITEEL---------------------DGPYIRNTLEKDPTSSREEALVEIYRRLRPGEPPTVEAARSLLENLFFDPKR 315
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  401 YDLSKVGRMKFNRRVGRDEIVGPMTLQDDDILATIKILVELRNGKGEVDDIDHLGNRRVRCVGELAENQFRAGLVRVERA 480
Cdd:PRK00405  316 YDLSKVGRYKLNKKLGLDEDEDVRVLTKEDIIATIKYLINLRNGKGEVDDIDHLGNRRVRSVGELLQNQFRIGLSRMERA 395
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  481 VKERLGQAESENLMPHDLINSKPISSAIREFFGSSQLSQFMDQTNPLSEITHKRRVSALGPGGLTRERAGFEVRDVHPTH 560
Cdd:PRK00405  396 VRERMSLQDLDTLTPQDLINAKPVVAAIKEFFGSSQLSQFMDQTNPLSELTHKRRLSALGPGGLTRERAGFEVRDVHPTH 475
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  561 YGRVCPIETPEGPNIGLINSLALYAHLNEYGFLETPYRKVVDSKVTDQIDYLSAIEEGRYMIAQANAAIDENGQLIDELV 640
Cdd:PRK00405  476 YGRICPIETPEGPNIGLINSLATYARVNEYGFIETPYRKVVDGKVTDEIVYLTADEEDNYVIAQANAPLDEDGRFVDELV 555
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  641 SSREAGETMMVTPDRIQYMDVAPSQIVSVAASLIPFLEHDDANRALMGSNMQRQAVPCLRPEKPVVGTGIERTCAVDSGT 720
Cdd:PRK00405  556 TARYKGEFVLVPPEEVDYMDVSPKQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPLLRPEAPLVGTGMERRVARDSGA 635
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  721 TVQAFRGGVVDYVDAGRIVIRVndDEAVAGEVGVDIYNLIKYTRSNQNTNINQRPIVKMGDKVSRGDVLADGASTDLGEL 800
Cdd:PRK00405  636 VVVAKRDGVVEYVDASRIVVRV--EELDPGEDGVDIYNLIKFQRSNQNTCINQRPIVKVGDRVEKGDVLADGPSTDNGEL 713
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  801 ALGQNMLIAFMPWNGYNFEDSILISEKVVADDRYTSIHIEELNVVARDTKLGPEEITRDISNLAEVQLGRLDESGIVYIG 880
Cdd:PRK00405  714 ALGQNVLVAFMPWNGYNFEDAILISERLVKEDVFTSIHIEEYEIEARDTKLGPEEITRDIPNVSEEALRNLDESGIVRIG 793
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  881 AEVEAGDVLVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDTSLRVPSGMSGTVIDVQVFTRegiqrdkraqqiiddelk 960
Cdd:PRK00405  794 AEVKPGDILVGKVTPKGETELTPEEKLLRAIFGEKARDVKDTSLRVPHGEEGTVIDVKVFTR------------------ 855
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  961 ryrldlndqlrivegdafqrlarmlvgkvanggpkklakgtkidqayledldhyhwfdirladdeaaaqleaiknsieek 1040
Cdd:PRK00405      --------------------------------------------------------------------------------
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1041 rhqfdlafeekrkkLTQGDELPPGVLKMVKVYLAVKRRLQPGDKMAGRHGNKGVVSKIVPIEDMPYMADGRPADVVLNPL 1120
Cdd:PRK00405  856 --------------IEQGDELPPGVNKLVKVYIAQKRKIQVGDKMAGRHGNKGVVSRILPVEDMPYLEDGTPVDIVLNPL 921
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1121 GVPSRMNVGQVLEVHLGWAAKGLGWRigemlqrqakieelrvfltkiynesgrqedlesftdeeilelaknlregvpFAT 1200
Cdd:PRK00405  922 GVPSRMNIGQILETHLGWAAKGLGIK---------------------------------------------------FAT 950
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1201 PVFDGATEEEMGKMLDLAFPDDIAqqldmnpsknQVRLYDGRTGEQFERRVTLGYMHYLKLHHLVDDKMHARSTGPYSLV 1280
Cdd:PRK00405  951 PVFDGAKEEEIKELLEEAGLPEDG----------KTTLYDGRTGEPFDRPVTVGYMYMLKLHHLVDDKIHARSTGPYSLV 1020
                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1281 TQQPLGGKAQFGGQRFGEMEVWALEAYGASYVLQEMLTVKSDDVTGRTKVYENLVKGDHVIDAGMPESFNVLVKEIRSLG 1360
Cdd:PRK00405 1021 TQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVVGRTKVYEAIVKGENIPEPGIPESFNVLVKELQSLG 1100

                  ....*
gi 500212820 1361 IDIDL 1365
Cdd:PRK00405 1101 LDVEL 1105
 
Name Accession Description Interval E-value
rpoB PRK00405
DNA-directed RNA polymerase subunit beta; Reviewed
1-1365 0e+00

DNA-directed RNA polymerase subunit beta; Reviewed


Pssm-ID: 234749 [Multi-domain]  Cd Length: 1112  Bit Score: 2187.57  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820    1 MQYSFTEKKRIRKSFAKRPIVHQVPFLLATQLESFSTFLQADVPATQrkpEGLQAAFTSVFPIVSHNGFARLEFVSYALS 80
Cdd:PRK00405    1 MVYSYTGKKRIRKSFGKIKEVLELPNLLEIQLDSFDWFLQLDVPPED---EGLEEVFRSIFPIEDFNGNLSLEFVSYELG 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   81 SPAFNIKECQQRGLTYCSALRAKVRLVILDkespnkpvVKEVKEQEVYMGEIPLMTPTGSFVINGTERVIVSQLHRSPGV 160
Cdd:PRK00405   78 EPKYDVEECKERGLTYSAPLRVKLRLINKE--------TGEIKEQEVYMGDIPLMTENGTFIINGTERVIVSQLHRSPGV 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  161 FFEHDKGKThSSGKLLFSARIIPYRGSWLDFEFDPKDILYFRVDRRRKMPVTILLKAIGLTPEQILANFFVFDNFTlmde 240
Cdd:PRK00405  150 YFDHDKDKT-SSGKLLYSARIIPYRGSWLEFEFDPKDILYVRIDRRRKLPVTVLLRALGYSDEEILDLFYEKEEFG---- 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  241 gaqlefvperlrgevarfditdrdgkvivqkdkrinakhirdleaaktKFISVPEDYLLGRVLAKNVVDGDTGEVIASAN 320
Cdd:PRK00405  225 ------------------------------------------------KEIEVPVEYLLGKVLAEDIVDEETGEVLAEAN 256
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  321 DEVTESVleklreagikdiqtlytndldQGPYISSTLRVDETTDRTAARIAIYRMMRPGEPPTEEAVEALFNRLFYSEEA 400
Cdd:PRK00405  257 DEITEEL---------------------DGPYIRNTLEKDPTSSREEALVEIYRRLRPGEPPTVEAARSLLENLFFDPKR 315
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  401 YDLSKVGRMKFNRRVGRDEIVGPMTLQDDDILATIKILVELRNGKGEVDDIDHLGNRRVRCVGELAENQFRAGLVRVERA 480
Cdd:PRK00405  316 YDLSKVGRYKLNKKLGLDEDEDVRVLTKEDIIATIKYLINLRNGKGEVDDIDHLGNRRVRSVGELLQNQFRIGLSRMERA 395
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  481 VKERLGQAESENLMPHDLINSKPISSAIREFFGSSQLSQFMDQTNPLSEITHKRRVSALGPGGLTRERAGFEVRDVHPTH 560
Cdd:PRK00405  396 VRERMSLQDLDTLTPQDLINAKPVVAAIKEFFGSSQLSQFMDQTNPLSELTHKRRLSALGPGGLTRERAGFEVRDVHPTH 475
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  561 YGRVCPIETPEGPNIGLINSLALYAHLNEYGFLETPYRKVVDSKVTDQIDYLSAIEEGRYMIAQANAAIDENGQLIDELV 640
Cdd:PRK00405  476 YGRICPIETPEGPNIGLINSLATYARVNEYGFIETPYRKVVDGKVTDEIVYLTADEEDNYVIAQANAPLDEDGRFVDELV 555
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  641 SSREAGETMMVTPDRIQYMDVAPSQIVSVAASLIPFLEHDDANRALMGSNMQRQAVPCLRPEKPVVGTGIERTCAVDSGT 720
Cdd:PRK00405  556 TARYKGEFVLVPPEEVDYMDVSPKQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPLLRPEAPLVGTGMERRVARDSGA 635
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  721 TVQAFRGGVVDYVDAGRIVIRVndDEAVAGEVGVDIYNLIKYTRSNQNTNINQRPIVKMGDKVSRGDVLADGASTDLGEL 800
Cdd:PRK00405  636 VVVAKRDGVVEYVDASRIVVRV--EELDPGEDGVDIYNLIKFQRSNQNTCINQRPIVKVGDRVEKGDVLADGPSTDNGEL 713
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  801 ALGQNMLIAFMPWNGYNFEDSILISEKVVADDRYTSIHIEELNVVARDTKLGPEEITRDISNLAEVQLGRLDESGIVYIG 880
Cdd:PRK00405  714 ALGQNVLVAFMPWNGYNFEDAILISERLVKEDVFTSIHIEEYEIEARDTKLGPEEITRDIPNVSEEALRNLDESGIVRIG 793
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  881 AEVEAGDVLVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDTSLRVPSGMSGTVIDVQVFTRegiqrdkraqqiiddelk 960
Cdd:PRK00405  794 AEVKPGDILVGKVTPKGETELTPEEKLLRAIFGEKARDVKDTSLRVPHGEEGTVIDVKVFTR------------------ 855
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  961 ryrldlndqlrivegdafqrlarmlvgkvanggpkklakgtkidqayledldhyhwfdirladdeaaaqleaiknsieek 1040
Cdd:PRK00405      --------------------------------------------------------------------------------
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1041 rhqfdlafeekrkkLTQGDELPPGVLKMVKVYLAVKRRLQPGDKMAGRHGNKGVVSKIVPIEDMPYMADGRPADVVLNPL 1120
Cdd:PRK00405  856 --------------IEQGDELPPGVNKLVKVYIAQKRKIQVGDKMAGRHGNKGVVSRILPVEDMPYLEDGTPVDIVLNPL 921
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1121 GVPSRMNVGQVLEVHLGWAAKGLGWRigemlqrqakieelrvfltkiynesgrqedlesftdeeilelaknlregvpFAT 1200
Cdd:PRK00405  922 GVPSRMNIGQILETHLGWAAKGLGIK---------------------------------------------------FAT 950
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1201 PVFDGATEEEMGKMLDLAFPDDIAqqldmnpsknQVRLYDGRTGEQFERRVTLGYMHYLKLHHLVDDKMHARSTGPYSLV 1280
Cdd:PRK00405  951 PVFDGAKEEEIKELLEEAGLPEDG----------KTTLYDGRTGEPFDRPVTVGYMYMLKLHHLVDDKIHARSTGPYSLV 1020
                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1281 TQQPLGGKAQFGGQRFGEMEVWALEAYGASYVLQEMLTVKSDDVTGRTKVYENLVKGDHVIDAGMPESFNVLVKEIRSLG 1360
Cdd:PRK00405 1021 TQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVVGRTKVYEAIVKGENIPEPGIPESFNVLVKELQSLG 1100

                  ....*
gi 500212820 1361 IDIDL 1365
Cdd:PRK00405 1101 LDVEL 1105
rpoB TIGR02013
DNA-directed RNA polymerase, beta subunit; This model describes orthologs of the beta subunit ...
8-1365 0e+00

DNA-directed RNA polymerase, beta subunit; This model describes orthologs of the beta subunit of Bacterial RNA polymerase. The core enzyme consists of two alpha chains, one beta chain, and one beta' subunit. [Transcription, DNA-dependent RNA polymerase]


Pssm-ID: 273928 [Multi-domain]  Cd Length: 1065  Bit Score: 1755.33  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820     8 KKRIRKSFAKRPIVHQVPFLLATQLESFSTFLQADVPATQRKPEGLQAAFTSVFPIVSHNGFARLEFVSYALSSPAFNIK 87
Cdd:TIGR02013    1 KKRIRIDFGKIPEVLEVPNLLEIQLDSYDWFLQQDTPPEKRKEEGLEEVFKSIFPIEDYTGNIELEYLSYRLGEPKYSVE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820    88 ECQQRGLTYCSALRAKVRLVILDKespnkPVVKEVKEQEVYMGEIPLMTPTGSFVINGTERVIVSQLHRSPGVFFEHDKG 167
Cdd:TIGR02013   81 ECKERGLTYSAPLKVKLRLINKEE-----DGTKEIKEQDVYMGDIPLMTDRGTFIINGAERVVVSQLHRSPGVFFSSEKD 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   168 kTHSSGKLLFSARIIPYRGSWLDFEFDPKDILYFRVDRRRKMPVTILLKAIGLTpeqilanffvfdnftlmdegaqlefv 247
Cdd:TIGR02013  156 -TTKSGKVLFSARIIPYRGSWLEFETDKKDVLYVRIDRKRKLPATVLLRALGYT-------------------------- 208
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   248 perlrgevarfditdrdgkvivqkdkrinakhirdleaaktkfisvpedyllgrvlaknvvdgdtgeviasandevtesv 327
Cdd:TIGR02013      --------------------------------------------------------------------------------
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   328 leklreagikdIQTLYTNDLDQGPYISSTLRVDETTDRTAARIAIYRMMRPGEPPTEEAVEALFNRLFYSEEAYDLSKVG 407
Cdd:TIGR02013  209 -----------IDTLILNRLGSGEYIRNTLRKDPTNSEEEALVEIYRKLRPGEPPTVEAARSLLENLFFDPKRYDLGRVG 277
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   408 RMKFNRRVGRDEIVGPMTLQDDDILATIKILVELRNGKGEVDDIDHLGNRRVRCVGELAENQFRAGLVRVERAVKERLGQ 487
Cdd:TIGR02013  278 RYKLNKKLGLDVPESIGVLTKEDIIATIKYLIKLRNGKGEIDDIDHLGNRRIRSVGELLQNQFRVGLARMERIVRERMST 357
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   488 AESENLMPHDLINSKPISSAIREFFGSSQLSQFMDQTNPLSEITHKRRVSALGPGGLTRERAGFEVRDVHPTHYGRVCPI 567
Cdd:TIGR02013  358 QDTDTLTPQDLINAKPISAAIKEFFGSSQLSQFMDQTNPLAELTHKRRLSALGPGGLTRERAGFEVRDVHPTHYGRICPI 437
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   568 ETPEGPNIGLINSLALYAHLNEYGFLETPYRKVVDSKV--TDQIDYLSAIEEGRYMIAQANAAIDENGQLIDELVSSREA 645
Cdd:TIGR02013  438 ETPEGPNIGLINSLSTYARVNEYGFIETPYRKVKDGKVvvTDEIDYLTADEEDNYVIAQANAPLDENGRFVEDLVVARYR 517
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   646 GETMMVTPDRIQYMDVAPSQIVSVAASLIPFLEHDDANRALMGSNMQRQAVPCLRPEKPVVGTGIERTCAVDSGTTVQAF 725
Cdd:TIGR02013  518 GEITLVSPDQVDYMDVSPKQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPLLRSEAPLVGTGMEAKVARDSGAVIVAK 597
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   726 RGGVVDYVDAGRIVIRvNDDEAVAGEVGVDIYNLIKYTRSNQNTNINQRPIVKMGDKVSRGDVLADGASTDLGELALGQN 805
Cdd:TIGR02013  598 RGGVVEYVDAKRIVIR-YDEDEEEPDGGIDIYRLLKYQRSNQDTCINQRPIVSVGDRVEAGDVLADGPSTDLGELALGRN 676
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   806 MLIAFMPWNGYNFEDSILISEKVVADDRYTSIHIEELNVVARDTKLGPEEITRDISNLAEVQLGRLDESGIVYIGAEVEA 885
Cdd:TIGR02013  677 VLVAFMPWNGYNYEDAILISERLVKDDVFTSIHIEEYEVEARDTKLGPEEITRDIPNVSEEALRNLDENGIVRIGAEVKA 756
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   886 GDVLVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDTSLRVPSGMSGTVIDVQVFTREgiqrdkraqqiiddelkryrld 965
Cdd:TIGR02013  757 GDILVGKVTPKGETELTPEEKLLRAIFGEKARDVRDTSLRVPPGVEGTVIDVKVFSRE---------------------- 814
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   966 lndqlrivegdafqrlarmlvgkvanggpkklakgtkidqayledldhyhwfdirladdeaaaqleaiknsieekrhqfd 1045
Cdd:TIGR02013      --------------------------------------------------------------------------------
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  1046 lafeekrkkltQGDELPPGVLKMVKVYLAVKRRLQPGDKMAGRHGNKGVVSKIVPIEDMPYMADGRPADVVLNPLGVPSR 1125
Cdd:TIGR02013  815 -----------QGDELPPGVNKLVKVYIAQKRKIQVGDKMAGRHGNKGVVSKILPIEDMPFLEDGTPVDIVLNPLGVPSR 883
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  1126 MNVGQVLEVHLGWAAKGLGwrigemlqrqakieelrvfltkiynesgrqedlesftdeeilelaknlREGVPFATPVFDG 1205
Cdd:TIGR02013  884 MNIGQILETHLGWAGKRLG------------------------------------------------RKGVPIATPVFDG 915
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  1206 ATEEEMGKMLDLAFPddiaqqldmnPSKNQVRLYDGRTGEQFERRVTLGYMHYLKLHHLVDDKMHARSTGPYSLVTQQPL 1285
Cdd:TIGR02013  916 ASEEEIKEYLEKAGL----------PRDGKVRLYDGRTGEQFDRPVTVGYMYMLKLHHLVDDKMHARSTGPYSLVTQQPL 985
                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  1286 GGKAQFGGQRFGEMEVWALEAYGASYVLQEMLTVKSDDVTGRTKVYENLVKGDHVIDAGMPESFNVLVKEIRSLGIDIDL 1365
Cdd:TIGR02013  986 GGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVVGRTKAYEAIVKGENVPEPGIPESFNVLIKELQSLGLDIEL 1065
RpoB COG0085
DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA ...
12-1365 0e+00

DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA polymerase, beta subunit/140 kD subunit is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 439855 [Multi-domain]  Cd Length: 1001  Bit Score: 1569.72  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   12 RKSFAKRPIVHQVPFLLATQLESFSTFLQadvpatqrkpEGLQAAFTSVFPIVSHNGFARLEFVSYALSSPAFNIKECQQ 91
Cdd:COG0085     1 RWSFAKIKEPLELPNLLEIQLDSFNWFLE----------EGLQEIFDEISPIEDFTGNLSLEFGDYRLGEPKYTPEECKE 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   92 RGLTYCSALRAKVRLVilDKESpnkpvvKEVKEQEVYMGEIPLMTPTGSFVINGTERVIVSQLHRSPGVFFEHDKGKths 171
Cdd:COG0085    71 RDLTYAAPLYVKVRLV--NKET------GEIKEQEVFMGDFPLMTDSGTFIINGTERVIVSQLVRSPGVYFVEEEDK--- 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  172 SGKLLFSARIIPYRGSWLDFEFDPKDILYFRVDRRRKMPVTILLKAIGLTpeqilanffvfdnftlmdegaqlefvperl 251
Cdd:COG0085   140 SGKDLYSAKVIPSRGAWLEFETDKDGTIYVRIDRKRKIPVTVLLRALGLE------------------------------ 189
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  252 rgevarfdiTDRDgkvivqkdkrinakhIRDLeaaktkFISVPEDyllgrvlaknvvdgdtgeviasandevtesvlekl 331
Cdd:COG0085   190 ---------TDEE---------------ILEA------FGDDPIQ----------------------------------- 204
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  332 reagikdiqtlytndldqgPYISSTLRVDETTDRTAARIAIYRMMRPGEPPTEEAVEALFNRLFYSEEAYDLSKVGRMKF 411
Cdd:COG0085   205 -------------------EYILATLEKDNTKTQEEALLEIYRKLRPGEPPTIERAEQLLDNLFFDPKRYDLAHVGRYKI 265
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  412 NRRVGRDEIVGPMTLQDDDILATIKILVELRNGKGEVDDIDHLGNRRVRCVGELAENQFRAGLVRVERAVKERLGQAESE 491
Cdd:COG0085   266 NKKLGLDVPPEDRVLTAEDIVATIKYLLELHLGEREPDDIDHLGNRRVRLVGELLQNQFRVGLSRMERVVRERMTTQDVE 345
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  492 NLMPHDLINSKPISSAIREFFGSSQLSQFMDQTNPLSEITHKRRVSALGPGGLTRERAGFEVRDVHPTHYGRVCPIETPE 571
Cdd:COG0085   346 AITPQSLINIRPVVAAIKEFFGSSQLSQFMDQTNPLSELTHKRRLSALGPGGLSRERAGFEVRDVHPSHYGRMCPIETPE 425
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  572 GPNIGLINSLALYAHLNEYGFLETPYRKVVDSKVTDQIDYLSAIEEGRYMIAQANAAIDENGQLIDELVSSREAGETMMV 651
Cdd:COG0085   426 GPNIGLIGSLALYARVNEYGFIETPYRKVENGKVTDEIEYLTADEEENYYIAQANAPLDEDGNFLEERVLVRYRGEEVLV 505
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  652 TPDRIQYMDVAPSQIVSVAASLIPFLEHDDANRALMGSNMQRQAVPCLRPEKPvvgtgiertcavdsgttvqafrggvvd 731
Cdd:COG0085   506 PPEEVDYMDVSPKQIVSVATSLIPFLEHDDANRALMGANMQRQAVPLLRPEAP--------------------------- 558
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  732 yvdagrivirvnddeavagevgVDIYNLIKYTRSNQNTNINQRPIVKMGDKVSRGDVLADGASTDLGELALGQNMLIAFM 811
Cdd:COG0085   559 ----------------------LLHYPLQKFQRSNQGTCINQRPIVRVGDRVEKGDVLADGPATDNGELALGQNLLVAFM 616
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  812 PWNGYNFEDSILISEKVVADDRYTSIHIEELNVVARDTKLGPEEITRDISNLAEVQLGRLDESGIVYIGAEVEAGDVLVG 891
Cdd:COG0085   617 PWEGYNYEDAIIISERLVKDDVLTSIHIEEYEIEARDTKLGPEEITRDIPNVSEEALRNLDEDGIIRIGAEVKGGDILVG 696
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  892 KVTPKGETQLTPEEKLLRAIFGEKASDVKDTSLRVPSGMSGTVIDVQVFTREgiqrdkraqqiiddelkryrldlndqlr 971
Cdd:COG0085   697 KVTPKGETELTPEERLLRAIFGEKAREVRDTSLRVPHGEKGKVIDVKVFSRE---------------------------- 748
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  972 ivegdafqrlarmlvgkvanggpkklakgtkidqayledldhyhwfdirladdeaaaqleaiknsieekrhqfdlafeek 1051
Cdd:COG0085       --------------------------------------------------------------------------------
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1052 rkkltQGDELPPGVLKMVKVYLAVKRRLQPGDKMAGRHGNKGVVSKIVPIEDMPYMADGRPADVVLNPLGVPSRMNVGQV 1131
Cdd:COG0085   749 -----EGDELPPGVNKLVRVYVAQKRKIEVGDKLAGRHGNKGVISRILPQEDMPFLEDGTPVDIVLNPLGVPSRMNVGQV 823
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1132 LEVHLGWAAKGLGWRIgemlqrqakieelrvfltkiynesgrqedlesftdeeilelaknlregvpfATPVFDGATEEEM 1211
Cdd:COG0085   824 LETHLGWAAALLGRRV---------------------------------------------------ATPVFDGAPEEEI 852
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1212 GKMLDLAfpddiaqqldMNPSKNQVRLYDGRTGEQFERRVTLGYMHYLKLHHLVDDKMHARSTGPYSLVTQQPLGGKAQF 1291
Cdd:COG0085   853 RELLEKA----------GLPPDGKEVLYDGRTGEPFDNPVTVGYMYYLKLHHMVDDKIHARSTGPYSLITQQPLGGKAQF 922
                        1290      1300      1310      1320      1330      1340      1350
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 500212820 1292 GGQRFGEMEVWALEAYGASYVLQEMLTVKSDDVTGRTKVYENLVKGDHVIDAGMPESFNVLVKEIRSLGIDIDL 1365
Cdd:COG0085   923 GGQRFGEMEVWALEAYGAAYTLQERLTIKSDDVCGRVKVYEAIVKGENIPEPGIPESFKVLLKELQSLGLDVEV 996
RNA_pol_B_RPB2 cd00653
RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. ...
27-1366 0e+00

RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase complex contains two related members of this family, in each case they are the two largest subunits.The clamp is a mobile structure that grips DNA during elongation.


Pssm-ID: 238353 [Multi-domain]  Cd Length: 866  Bit Score: 864.57  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   27 LLATQLESFSTFLQadvpatqrkpEGLQAAFTSVFPIVS--HNGFARLEFVSYALSSP---------AFNIKECQQRGLT 95
Cdd:cd00653     1 LVKQQIDSFNYFLN----------VGLQEIVKSIPPITDtdDDGRLKLKFGDIYLGKPkveeggvtrKLTPNECRLRDLT 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   96 YCSALRAKVRLVILDKEspnkpvvkEVKEQEVYMGEIPLMT------------------------PTGSFVINGTERVIV 151
Cdd:cd00653    71 YSAPLYVDIRLTVNDKG--------KIKEQEVFIGEIPIMLrsklcnlngltpeeliklgecpldPGGYFIINGTEKVII 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  152 SQLHRSPGVFFEHDkgkthSSGKLLFSARIIP----YRGSWLDFEFDpkdilyfrvdrrrkmpvtillkaigltpeqila 227
Cdd:cd00653   143 NQEQRSPNVIIVED-----SKGKRIYTKTSIPsyspYRGSWLEVKSD--------------------------------- 184
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  228 nffvfdnftlmdegaqlefvperlrgevarfditdrdgkvivQKDKRINAKHirdleaaktkfisvpedyllgrvlaknv 307
Cdd:cd00653   185 ------------------------------------------KKKDRIYVRI---------------------------- 194
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  308 vdgdtgeviasandevtesvleklreagikdiqtlytndldqgPYIsstlrvdettdrtaariaiyrmmrpgepPTEEAV 387
Cdd:cd00653   195 -------------------------------------------DLK----------------------------RQEEAL 203
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  388 EALFNRLFyseeaydlskvgrmkfnrrvgrdeivgpmtlqddDILATIKILVELRNGKGEVDDIDHLGNRRVRCVGELAE 467
Cdd:cd00653   204 KYIGKRFE----------------------------------DLIYMIRKLILLVLGKGKLDDIDHLGNKRVRLAGELLQ 249
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  468 NQFRAGLVRVERAVKERLGQAESEN--LMPHDLINSKPISSAIREFFGSSQ------------LSQFMDQTNPLSEITHK 533
Cdd:cd00653   250 NLFRSGLKRLEREVKEKLQKQLSKKkdLTPQLLINSKPITSGIKEFLATGNwgskrflmqrsgLSQVLDRLNPLSELSHK 329
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  534 RRVSAlgpGGLTRERAGFEVRDVHPTHYGRVCPIETPEGPNIGLINSLALYAHLNeyGFLETPYRKvVDSKVTdqidyls 613
Cdd:cd00653   330 RRISS---LGLFRERKGFEVRDLHPSHWGRICPIETPEGENCGLVKNLALMARIS--GRIERPYRI-VEKEVT------- 396
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  614 aieegrymiaqanaaidengqlidelvssreagetmmvtpdriqYMDVAPSQIVSVAASLIPFLEHDDANRALMGSNMQR 693
Cdd:cd00653   397 --------------------------------------------HIEISPSQILSVAASLIPFPEHNQSPRNLYQSNMQK 432
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  694 QAVP----------------CLRPEKPVVGTGIErtcavdsgttvqafrggvvdyvdagrivirvnddeavagevgvdiy 757
Cdd:cd00653   433 QAVGtpalnqqyrmdtklylLLYPQKPLVGTGIE---------------------------------------------- 466
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  758 NLIKYtrsnqntninqrpivkmgdkvsrgdvladgastdlGELALGQNMLIAFMPWNGYNFEDSILISEKVVADDRYTSI 837
Cdd:cd00653   467 EYIAF-----------------------------------GELPLGQNAIVAVMSYSGYNFEDAIIINKSSVDRGFFRSI 511
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  838 HIEELNVVARDTKLGPEEITR-DISNLAEVQLGRLDESGIVYIGAEVEAGDVLVGKVTPKGETQLTPeekllraIFGEKA 916
Cdd:cd00653   512 HYKKYEIELRKTKNGPEEITRgDIPNVSEEKLKNLDEDGIIRPGARVEPGDILVGKITPKGETESTP-------IFGEKA 584
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  917 SDVKDTSLRVPSGMSGTVIDVQVFTRegiqrdkraqqiiddelkryrldlndqlrivegdafqrlarmlvgkvanggpkk 996
Cdd:cd00653   585 RDVRDTSLKYPGGEKGIVDDVKIFSR------------------------------------------------------ 610
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  997 lakgtkidqayledldhyhwfdirladdeaaaqleaiknsieekrhqfdlafeekrkkltqgdELPPGVLKMVKVYLAVK 1076
Cdd:cd00653   611 ---------------------------------------------------------------ELNDGGNKLVKVYIRQK 627
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1077 RRLQPGDKMAGRHGNKGVVSKIVPIEDMPYMADGRPADVVLNPLGVPSRMNVGQVLEVHLGWAAKGLGWRIgemlqrqak 1156
Cdd:cd00653   628 RKPQIGDKFASRHGQKGVISKILPQEDMPFTEDGIPPDIILNPHGFPSRMTIGQLLESLLGKAGALLGKFG--------- 698
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1157 ieelrvfltkiynesgrqedlesftdeeilelaknlregvpFATPvFDGATEEEMGKMLDLAFPDdiaqqldmNPSKnqV 1236
Cdd:cd00653   699 -----------------------------------------DATP-FDGAEEEDISELLGEAGLN--------YYGK--E 726
                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1237 RLYDGRTGEQFERRVTLGYMHYLKLHHLVDDKMHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGASYVLQEM 1316
Cdd:cd00653   727 VLYDGRTGEPLEAPIFVGPVYYQRLKHMVDDKIHARSTGPYSLLTRQPLKGRSRGGGQRFGEMERDALIAHGAAYLLQER 806
                        1370      1380      1390      1400      1410      1420
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1317 LTVKSDDVTGRTKVYENLV----------KGDHVIDAGMPESFNVLVKEIRSLGIDIDLD 1366
Cdd:cd00653   807 LTIKSDDVVARVCVKCGIIlsanlcrlckKGTNISKVGIPYAFKLLFQELQSMNIDPRLK 866
RNA_pol_Rpb2_6 pfam00562
RNA polymerase Rpb2, domain 6; RNA polymerases catalyze the DNA dependent polymerization of ...
724-1290 1.86e-160

RNA polymerase Rpb2, domain 6; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain represents the hybrid binding domain and the wall domain. The hybrid binding domain binds the nascent RNA strand / template DNA strand in the Pol II transcription elongation complex. This domain contains the important structural motifs, switch 3 and the flap loop and binds an active site metal ion. This domain is also involved in binding to Rpb1 and Rpb3. Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 2 (DRII).


Pssm-ID: 459854 [Multi-domain]  Cd Length: 371  Bit Score: 486.27  E-value: 1.86e-160
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   724 AFRGGVVDYVDAGRIVIRVNDDEAVAGevgvdIYNLIKYTRSNQNT---NINQRPIVKMGdKVSRGDvladgastdLGEL 800
Cdd:pfam00562    2 ASLIPFVDHNQSPRNTYQCAMGKQAMG-----IYTLNKFYRSDQNTyvlCYPQKPLVKTG-AVEAGG---------FGEL 66
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   801 ALGQNMLIAFMPWNGYNFEDSILISEKVVADDRYTSIHIEElnVVARDTKLGP-EEITRDISNLAEVQLGRLDESGIVYI 879
Cdd:pfam00562   67 PLGQNAIVAVMSYTGYNQEDAIIINKSSVDRGFFTSIHIKE--IEARKTKLGPiEEITRDIPNVSEEALKKLDEDGIVRV 144
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   880 GAEVEAGDVLVGKVtpkGETQLTpeeKLLRAIFGEKASDVKDTSLRVPSGMSGTVIDVQVFTregiqrdkraqqiiddel 959
Cdd:pfam00562  145 GAEVKPGDILVGKV---GPTELT---KLLRAIFGEKARDVKDTSLKVPPGEEGVVDDVIVFE------------------ 200
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   960 kryrldlndqlrivegdafqrlarmlvgkvanggpkklakgtkidqayledldhyhwfdirladdeaaaqleaiknsiee 1039
Cdd:pfam00562      --------------------------------------------------------------------------------
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  1040 krhqfdlafeekrkkltqgdeLPPGVLKMVKVYLAVKRRLQPGDKMAGRHGNKGVVSKIVPIEDMPYMADGRPADVVLNP 1119
Cdd:pfam00562  201 ---------------------LPPGGIKMVKVYIRQKRKPEVGDKFASRHGQKGVVSRILPQEDMPFTEDGIPPDIILNP 259
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  1120 LGVPSRMNVGQVLEVHLGWAAKGLgwrigemlqrqakieelrvfltkiynesgrqedlesftdeeilelaknlreGVPFA 1199
Cdd:pfam00562  260 HGVPSRMTIGQLLETHLGKAAALL---------------------------------------------------GVFVD 288
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  1200 TPVFDGATEEemgkmldlafPDDIAQQLD---MNPSKNQVrLYDGRTGEQFERRVTLGYMHYLKLHHLVDDKMHARSTGP 1276
Cdd:pfam00562  289 ATPFDGASTE----------VEDIGELLEkagYNYYGKEV-LYDGRTGEPFEAPIFVGPIYYQKLKHMVDDKIHARSTGP 357
                          570
                   ....*....|....
gi 500212820  1277 YSLVTQQPLGGKAQ 1290
Cdd:pfam00562  358 YSLLTRQPLGGRAR 371
 
Name Accession Description Interval E-value
rpoB PRK00405
DNA-directed RNA polymerase subunit beta; Reviewed
1-1365 0e+00

DNA-directed RNA polymerase subunit beta; Reviewed


Pssm-ID: 234749 [Multi-domain]  Cd Length: 1112  Bit Score: 2187.57  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820    1 MQYSFTEKKRIRKSFAKRPIVHQVPFLLATQLESFSTFLQADVPATQrkpEGLQAAFTSVFPIVSHNGFARLEFVSYALS 80
Cdd:PRK00405    1 MVYSYTGKKRIRKSFGKIKEVLELPNLLEIQLDSFDWFLQLDVPPED---EGLEEVFRSIFPIEDFNGNLSLEFVSYELG 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   81 SPAFNIKECQQRGLTYCSALRAKVRLVILDkespnkpvVKEVKEQEVYMGEIPLMTPTGSFVINGTERVIVSQLHRSPGV 160
Cdd:PRK00405   78 EPKYDVEECKERGLTYSAPLRVKLRLINKE--------TGEIKEQEVYMGDIPLMTENGTFIINGTERVIVSQLHRSPGV 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  161 FFEHDKGKThSSGKLLFSARIIPYRGSWLDFEFDPKDILYFRVDRRRKMPVTILLKAIGLTPEQILANFFVFDNFTlmde 240
Cdd:PRK00405  150 YFDHDKDKT-SSGKLLYSARIIPYRGSWLEFEFDPKDILYVRIDRRRKLPVTVLLRALGYSDEEILDLFYEKEEFG---- 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  241 gaqlefvperlrgevarfditdrdgkvivqkdkrinakhirdleaaktKFISVPEDYLLGRVLAKNVVDGDTGEVIASAN 320
Cdd:PRK00405  225 ------------------------------------------------KEIEVPVEYLLGKVLAEDIVDEETGEVLAEAN 256
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  321 DEVTESVleklreagikdiqtlytndldQGPYISSTLRVDETTDRTAARIAIYRMMRPGEPPTEEAVEALFNRLFYSEEA 400
Cdd:PRK00405  257 DEITEEL---------------------DGPYIRNTLEKDPTSSREEALVEIYRRLRPGEPPTVEAARSLLENLFFDPKR 315
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  401 YDLSKVGRMKFNRRVGRDEIVGPMTLQDDDILATIKILVELRNGKGEVDDIDHLGNRRVRCVGELAENQFRAGLVRVERA 480
Cdd:PRK00405  316 YDLSKVGRYKLNKKLGLDEDEDVRVLTKEDIIATIKYLINLRNGKGEVDDIDHLGNRRVRSVGELLQNQFRIGLSRMERA 395
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  481 VKERLGQAESENLMPHDLINSKPISSAIREFFGSSQLSQFMDQTNPLSEITHKRRVSALGPGGLTRERAGFEVRDVHPTH 560
Cdd:PRK00405  396 VRERMSLQDLDTLTPQDLINAKPVVAAIKEFFGSSQLSQFMDQTNPLSELTHKRRLSALGPGGLTRERAGFEVRDVHPTH 475
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  561 YGRVCPIETPEGPNIGLINSLALYAHLNEYGFLETPYRKVVDSKVTDQIDYLSAIEEGRYMIAQANAAIDENGQLIDELV 640
Cdd:PRK00405  476 YGRICPIETPEGPNIGLINSLATYARVNEYGFIETPYRKVVDGKVTDEIVYLTADEEDNYVIAQANAPLDEDGRFVDELV 555
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  641 SSREAGETMMVTPDRIQYMDVAPSQIVSVAASLIPFLEHDDANRALMGSNMQRQAVPCLRPEKPVVGTGIERTCAVDSGT 720
Cdd:PRK00405  556 TARYKGEFVLVPPEEVDYMDVSPKQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPLLRPEAPLVGTGMERRVARDSGA 635
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  721 TVQAFRGGVVDYVDAGRIVIRVndDEAVAGEVGVDIYNLIKYTRSNQNTNINQRPIVKMGDKVSRGDVLADGASTDLGEL 800
Cdd:PRK00405  636 VVVAKRDGVVEYVDASRIVVRV--EELDPGEDGVDIYNLIKFQRSNQNTCINQRPIVKVGDRVEKGDVLADGPSTDNGEL 713
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  801 ALGQNMLIAFMPWNGYNFEDSILISEKVVADDRYTSIHIEELNVVARDTKLGPEEITRDISNLAEVQLGRLDESGIVYIG 880
Cdd:PRK00405  714 ALGQNVLVAFMPWNGYNFEDAILISERLVKEDVFTSIHIEEYEIEARDTKLGPEEITRDIPNVSEEALRNLDESGIVRIG 793
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  881 AEVEAGDVLVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDTSLRVPSGMSGTVIDVQVFTRegiqrdkraqqiiddelk 960
Cdd:PRK00405  794 AEVKPGDILVGKVTPKGETELTPEEKLLRAIFGEKARDVKDTSLRVPHGEEGTVIDVKVFTR------------------ 855
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  961 ryrldlndqlrivegdafqrlarmlvgkvanggpkklakgtkidqayledldhyhwfdirladdeaaaqleaiknsieek 1040
Cdd:PRK00405      --------------------------------------------------------------------------------
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1041 rhqfdlafeekrkkLTQGDELPPGVLKMVKVYLAVKRRLQPGDKMAGRHGNKGVVSKIVPIEDMPYMADGRPADVVLNPL 1120
Cdd:PRK00405  856 --------------IEQGDELPPGVNKLVKVYIAQKRKIQVGDKMAGRHGNKGVVSRILPVEDMPYLEDGTPVDIVLNPL 921
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1121 GVPSRMNVGQVLEVHLGWAAKGLGWRigemlqrqakieelrvfltkiynesgrqedlesftdeeilelaknlregvpFAT 1200
Cdd:PRK00405  922 GVPSRMNIGQILETHLGWAAKGLGIK---------------------------------------------------FAT 950
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1201 PVFDGATEEEMGKMLDLAFPDDIAqqldmnpsknQVRLYDGRTGEQFERRVTLGYMHYLKLHHLVDDKMHARSTGPYSLV 1280
Cdd:PRK00405  951 PVFDGAKEEEIKELLEEAGLPEDG----------KTTLYDGRTGEPFDRPVTVGYMYMLKLHHLVDDKIHARSTGPYSLV 1020
                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1281 TQQPLGGKAQFGGQRFGEMEVWALEAYGASYVLQEMLTVKSDDVTGRTKVYENLVKGDHVIDAGMPESFNVLVKEIRSLG 1360
Cdd:PRK00405 1021 TQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVVGRTKVYEAIVKGENIPEPGIPESFNVLVKELQSLG 1100

                  ....*
gi 500212820 1361 IDIDL 1365
Cdd:PRK00405 1101 LDVEL 1105
rpoB TIGR02013
DNA-directed RNA polymerase, beta subunit; This model describes orthologs of the beta subunit ...
8-1365 0e+00

DNA-directed RNA polymerase, beta subunit; This model describes orthologs of the beta subunit of Bacterial RNA polymerase. The core enzyme consists of two alpha chains, one beta chain, and one beta' subunit. [Transcription, DNA-dependent RNA polymerase]


Pssm-ID: 273928 [Multi-domain]  Cd Length: 1065  Bit Score: 1755.33  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820     8 KKRIRKSFAKRPIVHQVPFLLATQLESFSTFLQADVPATQRKPEGLQAAFTSVFPIVSHNGFARLEFVSYALSSPAFNIK 87
Cdd:TIGR02013    1 KKRIRIDFGKIPEVLEVPNLLEIQLDSYDWFLQQDTPPEKRKEEGLEEVFKSIFPIEDYTGNIELEYLSYRLGEPKYSVE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820    88 ECQQRGLTYCSALRAKVRLVILDKespnkPVVKEVKEQEVYMGEIPLMTPTGSFVINGTERVIVSQLHRSPGVFFEHDKG 167
Cdd:TIGR02013   81 ECKERGLTYSAPLKVKLRLINKEE-----DGTKEIKEQDVYMGDIPLMTDRGTFIINGAERVVVSQLHRSPGVFFSSEKD 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   168 kTHSSGKLLFSARIIPYRGSWLDFEFDPKDILYFRVDRRRKMPVTILLKAIGLTpeqilanffvfdnftlmdegaqlefv 247
Cdd:TIGR02013  156 -TTKSGKVLFSARIIPYRGSWLEFETDKKDVLYVRIDRKRKLPATVLLRALGYT-------------------------- 208
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   248 perlrgevarfditdrdgkvivqkdkrinakhirdleaaktkfisvpedyllgrvlaknvvdgdtgeviasandevtesv 327
Cdd:TIGR02013      --------------------------------------------------------------------------------
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   328 leklreagikdIQTLYTNDLDQGPYISSTLRVDETTDRTAARIAIYRMMRPGEPPTEEAVEALFNRLFYSEEAYDLSKVG 407
Cdd:TIGR02013  209 -----------IDTLILNRLGSGEYIRNTLRKDPTNSEEEALVEIYRKLRPGEPPTVEAARSLLENLFFDPKRYDLGRVG 277
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   408 RMKFNRRVGRDEIVGPMTLQDDDILATIKILVELRNGKGEVDDIDHLGNRRVRCVGELAENQFRAGLVRVERAVKERLGQ 487
Cdd:TIGR02013  278 RYKLNKKLGLDVPESIGVLTKEDIIATIKYLIKLRNGKGEIDDIDHLGNRRIRSVGELLQNQFRVGLARMERIVRERMST 357
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   488 AESENLMPHDLINSKPISSAIREFFGSSQLSQFMDQTNPLSEITHKRRVSALGPGGLTRERAGFEVRDVHPTHYGRVCPI 567
Cdd:TIGR02013  358 QDTDTLTPQDLINAKPISAAIKEFFGSSQLSQFMDQTNPLAELTHKRRLSALGPGGLTRERAGFEVRDVHPTHYGRICPI 437
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   568 ETPEGPNIGLINSLALYAHLNEYGFLETPYRKVVDSKV--TDQIDYLSAIEEGRYMIAQANAAIDENGQLIDELVSSREA 645
Cdd:TIGR02013  438 ETPEGPNIGLINSLSTYARVNEYGFIETPYRKVKDGKVvvTDEIDYLTADEEDNYVIAQANAPLDENGRFVEDLVVARYR 517
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   646 GETMMVTPDRIQYMDVAPSQIVSVAASLIPFLEHDDANRALMGSNMQRQAVPCLRPEKPVVGTGIERTCAVDSGTTVQAF 725
Cdd:TIGR02013  518 GEITLVSPDQVDYMDVSPKQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPLLRSEAPLVGTGMEAKVARDSGAVIVAK 597
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   726 RGGVVDYVDAGRIVIRvNDDEAVAGEVGVDIYNLIKYTRSNQNTNINQRPIVKMGDKVSRGDVLADGASTDLGELALGQN 805
Cdd:TIGR02013  598 RGGVVEYVDAKRIVIR-YDEDEEEPDGGIDIYRLLKYQRSNQDTCINQRPIVSVGDRVEAGDVLADGPSTDLGELALGRN 676
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   806 MLIAFMPWNGYNFEDSILISEKVVADDRYTSIHIEELNVVARDTKLGPEEITRDISNLAEVQLGRLDESGIVYIGAEVEA 885
Cdd:TIGR02013  677 VLVAFMPWNGYNYEDAILISERLVKDDVFTSIHIEEYEVEARDTKLGPEEITRDIPNVSEEALRNLDENGIVRIGAEVKA 756
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   886 GDVLVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDTSLRVPSGMSGTVIDVQVFTREgiqrdkraqqiiddelkryrld 965
Cdd:TIGR02013  757 GDILVGKVTPKGETELTPEEKLLRAIFGEKARDVRDTSLRVPPGVEGTVIDVKVFSRE---------------------- 814
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   966 lndqlrivegdafqrlarmlvgkvanggpkklakgtkidqayledldhyhwfdirladdeaaaqleaiknsieekrhqfd 1045
Cdd:TIGR02013      --------------------------------------------------------------------------------
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  1046 lafeekrkkltQGDELPPGVLKMVKVYLAVKRRLQPGDKMAGRHGNKGVVSKIVPIEDMPYMADGRPADVVLNPLGVPSR 1125
Cdd:TIGR02013  815 -----------QGDELPPGVNKLVKVYIAQKRKIQVGDKMAGRHGNKGVVSKILPIEDMPFLEDGTPVDIVLNPLGVPSR 883
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  1126 MNVGQVLEVHLGWAAKGLGwrigemlqrqakieelrvfltkiynesgrqedlesftdeeilelaknlREGVPFATPVFDG 1205
Cdd:TIGR02013  884 MNIGQILETHLGWAGKRLG------------------------------------------------RKGVPIATPVFDG 915
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  1206 ATEEEMGKMLDLAFPddiaqqldmnPSKNQVRLYDGRTGEQFERRVTLGYMHYLKLHHLVDDKMHARSTGPYSLVTQQPL 1285
Cdd:TIGR02013  916 ASEEEIKEYLEKAGL----------PRDGKVRLYDGRTGEQFDRPVTVGYMYMLKLHHLVDDKMHARSTGPYSLVTQQPL 985
                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  1286 GGKAQFGGQRFGEMEVWALEAYGASYVLQEMLTVKSDDVTGRTKVYENLVKGDHVIDAGMPESFNVLVKEIRSLGIDIDL 1365
Cdd:TIGR02013  986 GGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVVGRTKAYEAIVKGENVPEPGIPESFNVLIKELQSLGLDIEL 1065
RpoB COG0085
DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA ...
12-1365 0e+00

DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA polymerase, beta subunit/140 kD subunit is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 439855 [Multi-domain]  Cd Length: 1001  Bit Score: 1569.72  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   12 RKSFAKRPIVHQVPFLLATQLESFSTFLQadvpatqrkpEGLQAAFTSVFPIVSHNGFARLEFVSYALSSPAFNIKECQQ 91
Cdd:COG0085     1 RWSFAKIKEPLELPNLLEIQLDSFNWFLE----------EGLQEIFDEISPIEDFTGNLSLEFGDYRLGEPKYTPEECKE 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   92 RGLTYCSALRAKVRLVilDKESpnkpvvKEVKEQEVYMGEIPLMTPTGSFVINGTERVIVSQLHRSPGVFFEHDKGKths 171
Cdd:COG0085    71 RDLTYAAPLYVKVRLV--NKET------GEIKEQEVFMGDFPLMTDSGTFIINGTERVIVSQLVRSPGVYFVEEEDK--- 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  172 SGKLLFSARIIPYRGSWLDFEFDPKDILYFRVDRRRKMPVTILLKAIGLTpeqilanffvfdnftlmdegaqlefvperl 251
Cdd:COG0085   140 SGKDLYSAKVIPSRGAWLEFETDKDGTIYVRIDRKRKIPVTVLLRALGLE------------------------------ 189
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  252 rgevarfdiTDRDgkvivqkdkrinakhIRDLeaaktkFISVPEDyllgrvlaknvvdgdtgeviasandevtesvlekl 331
Cdd:COG0085   190 ---------TDEE---------------ILEA------FGDDPIQ----------------------------------- 204
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  332 reagikdiqtlytndldqgPYISSTLRVDETTDRTAARIAIYRMMRPGEPPTEEAVEALFNRLFYSEEAYDLSKVGRMKF 411
Cdd:COG0085   205 -------------------EYILATLEKDNTKTQEEALLEIYRKLRPGEPPTIERAEQLLDNLFFDPKRYDLAHVGRYKI 265
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  412 NRRVGRDEIVGPMTLQDDDILATIKILVELRNGKGEVDDIDHLGNRRVRCVGELAENQFRAGLVRVERAVKERLGQAESE 491
Cdd:COG0085   266 NKKLGLDVPPEDRVLTAEDIVATIKYLLELHLGEREPDDIDHLGNRRVRLVGELLQNQFRVGLSRMERVVRERMTTQDVE 345
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  492 NLMPHDLINSKPISSAIREFFGSSQLSQFMDQTNPLSEITHKRRVSALGPGGLTRERAGFEVRDVHPTHYGRVCPIETPE 571
Cdd:COG0085   346 AITPQSLINIRPVVAAIKEFFGSSQLSQFMDQTNPLSELTHKRRLSALGPGGLSRERAGFEVRDVHPSHYGRMCPIETPE 425
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  572 GPNIGLINSLALYAHLNEYGFLETPYRKVVDSKVTDQIDYLSAIEEGRYMIAQANAAIDENGQLIDELVSSREAGETMMV 651
Cdd:COG0085   426 GPNIGLIGSLALYARVNEYGFIETPYRKVENGKVTDEIEYLTADEEENYYIAQANAPLDEDGNFLEERVLVRYRGEEVLV 505
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  652 TPDRIQYMDVAPSQIVSVAASLIPFLEHDDANRALMGSNMQRQAVPCLRPEKPvvgtgiertcavdsgttvqafrggvvd 731
Cdd:COG0085   506 PPEEVDYMDVSPKQIVSVATSLIPFLEHDDANRALMGANMQRQAVPLLRPEAP--------------------------- 558
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  732 yvdagrivirvnddeavagevgVDIYNLIKYTRSNQNTNINQRPIVKMGDKVSRGDVLADGASTDLGELALGQNMLIAFM 811
Cdd:COG0085   559 ----------------------LLHYPLQKFQRSNQGTCINQRPIVRVGDRVEKGDVLADGPATDNGELALGQNLLVAFM 616
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  812 PWNGYNFEDSILISEKVVADDRYTSIHIEELNVVARDTKLGPEEITRDISNLAEVQLGRLDESGIVYIGAEVEAGDVLVG 891
Cdd:COG0085   617 PWEGYNYEDAIIISERLVKDDVLTSIHIEEYEIEARDTKLGPEEITRDIPNVSEEALRNLDEDGIIRIGAEVKGGDILVG 696
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  892 KVTPKGETQLTPEEKLLRAIFGEKASDVKDTSLRVPSGMSGTVIDVQVFTREgiqrdkraqqiiddelkryrldlndqlr 971
Cdd:COG0085   697 KVTPKGETELTPEERLLRAIFGEKAREVRDTSLRVPHGEKGKVIDVKVFSRE---------------------------- 748
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  972 ivegdafqrlarmlvgkvanggpkklakgtkidqayledldhyhwfdirladdeaaaqleaiknsieekrhqfdlafeek 1051
Cdd:COG0085       --------------------------------------------------------------------------------
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1052 rkkltQGDELPPGVLKMVKVYLAVKRRLQPGDKMAGRHGNKGVVSKIVPIEDMPYMADGRPADVVLNPLGVPSRMNVGQV 1131
Cdd:COG0085   749 -----EGDELPPGVNKLVRVYVAQKRKIEVGDKLAGRHGNKGVISRILPQEDMPFLEDGTPVDIVLNPLGVPSRMNVGQV 823
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1132 LEVHLGWAAKGLGWRIgemlqrqakieelrvfltkiynesgrqedlesftdeeilelaknlregvpfATPVFDGATEEEM 1211
Cdd:COG0085   824 LETHLGWAAALLGRRV---------------------------------------------------ATPVFDGAPEEEI 852
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1212 GKMLDLAfpddiaqqldMNPSKNQVRLYDGRTGEQFERRVTLGYMHYLKLHHLVDDKMHARSTGPYSLVTQQPLGGKAQF 1291
Cdd:COG0085   853 RELLEKA----------GLPPDGKEVLYDGRTGEPFDNPVTVGYMYYLKLHHMVDDKIHARSTGPYSLITQQPLGGKAQF 922
                        1290      1300      1310      1320      1330      1340      1350
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 500212820 1292 GGQRFGEMEVWALEAYGASYVLQEMLTVKSDDVTGRTKVYENLVKGDHVIDAGMPESFNVLVKEIRSLGIDIDL 1365
Cdd:COG0085   923 GGQRFGEMEVWALEAYGAAYTLQERLTIKSDDVCGRVKVYEAIVKGENIPEPGIPESFKVLLKELQSLGLDVEV 996
PRK09603 PRK09603
DNA-directed RNA polymerase subunit beta/beta';
8-1365 0e+00

DNA-directed RNA polymerase subunit beta/beta';


Pssm-ID: 181983 [Multi-domain]  Cd Length: 2890  Bit Score: 1416.22  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820    8 KKRIRKSFAKRPIVHQVPFLLATQLESFSTFLQADvpatQRKPEGLQAAFTSVFPIVSHNGFARLEFVSYALSSPAFNIK 87
Cdd:PRK09603    8 KNRLRADFTKTPTDLEVPNLLLLQRDSYDSFLYSK----DGKESGIEKVFKSIFPIQDEHNRITLEYAGCEFGKSKYTVR 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   88 ECQQRGLTYCSALRAKVRLVILDKE--SPNKPVVKEVKEQEVYMGEIPLMTPTGSFVINGTERVIVSQLHRSPGVFFEHD 165
Cdd:PRK09603   84 EAMERGITYSIPLKIKVRLILWEKDtkSGEKNGIKDIKEQSIFIREIPLMTERTSFIINGVERVVVNQLHRSPGVIFKEE 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  166 KGKThSSGKLLFSARIIPYRGSWLDFEFDPKDILYFRVDRRRKMPVTILLKAIGLTPEQILANFFVFDNFTLMDEGAQLE 245
Cdd:PRK09603  164 ESST-SLNKLIYTGQIIPDRGSWLYFEYDSKDVLYARINKRRKVPVTILFRAMDYQKQDIIKMFYPLVKVRYENDKYLIP 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  246 FVPERLRGEVaRFDITDRDGKVIVQKDKRINAKHIRDLEAAKTKFISVPEDYLLGRVLAKNVVDGDtgEVIASANDEVTE 325
Cdd:PRK09603  243 FASLDANQRM-EFDLKDPQGKIILLAGKKLTSRKIKELKENHLEWVEYPMDILLNRHLAEPVMVGK--EVLLDMLTQLDK 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  326 SVLEKLREAGIKDIqtLYTNDLDQG----------------PYISSTLRVDETTDRTAARIaiYRMMRPGEPPTEEAVEA 389
Cdd:PRK09603  320 NKLEKIHDLGVQEF--VIINDLALGhdasiihsfsadseslKLLKQTEKIDDENALAAIRI--HKVMKPGDPVTTEVAKQ 395
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  390 LFNRLFYSEEAYDLSKVGRMKFNRRVGRDEIVGPMTLQDDDILATIKILVELRNGKGEVDDIDHLGNRRVRCVGELAENQ 469
Cdd:PRK09603  396 FVKKLFFDPERYDLTMVGRMKMNHKLGLHVPDYITTLTHEDIITTVKYLMKIKNNQGKIDDRDHLGNRRIRAVGELLANE 475
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  470 FRAGLVRVERAVKERLGQAES--ENLMPHDLINSKPISSAIREFFGSSQLSQFMDQTNPLSEITHKRRVSALGPGGLTRE 547
Cdd:PRK09603  476 LHSGLVKMQKTIKDKLTTMSGafDSLMPHDLVNSKMITSTIMEFFMGGQLSQFMDQTNPLSEVTHKRRLSALGEGGLVKD 555
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  548 RAGFEVRDVHPTHYGRVCPIETPEGPNIGLINSLALYAHLNEYGFLETPYRKVVDSKVTDQIDYLSAIEEGRYMIAQANA 627
Cdd:PRK09603  556 RVGFEARDVHPTHYGRICPIETPEGQNIGLINTLSTFTRVNDLGFIEAPYKKVVDGKVVGETIYLTAIQEDSHIIAPAST 635
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  628 AIDENGQLIDELVSSREAGETMMVTPDRIQYMDVAPSQIVSVAASLIPFLEHDDANRALMGSNMQRQAVPCLRPEKPVVG 707
Cdd:PRK09603  636 PIDEEGNILGDLIETRVEGEIVLNEKSKVTLMDLSSSMLVGVAASLIPFLEHDDANRALMGTNMQRQAVPLLRSDAPIVG 715
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  708 TGIERTCAVDSGTTVQAFRGGVVDYVDAGRIVIRVNDDEavagEVGVDIYNLIKYTRSNQNTNINQRPIVKMGDKVSRGD 787
Cdd:PRK09603  716 TGIEKIIARDSWGAIKANRAGVVEKIDSKNIYILGEGKE----EAYIDAYSLQKNLRTNQNTSFNQVPIVKVGDKVEAGQ 791
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  788 VLADGASTDLGELALGQNMLIAFMPWNGYNFEDSILISEKVVADDRYTSIHIEELNVVARDTKLGPEEITRDISNLAEVQ 867
Cdd:PRK09603  792 IIADGPSMDRGELALGKNVRVAFMPWNGYNFEDAIVVSERITKDDIFTSTHIYEKEVDARELKHGVEEFTADIPDVKEEA 871
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  868 LGRLDESGIVYIGAEVEAGDVLVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDTSLRVPSGMSGTVIDVQVFTREGIQR 947
Cdd:PRK09603  872 LAHLDESGIVKVGTYVSAGMILVGKTSPKGEIKSTPEERLLRAIFGDKAGHVVNKSLYCPPSLEGTVIDVKVFTKKGYEK 951
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  948 DKRAQQIIDDELKRYRLDLNDQLRIVEGDAFQRLARML----VGKVANGGPKKLAKGTKIDQAYLEDLDHYHWFD-IRLA 1022
Cdd:PRK09603  952 DARVLSAYEEEKAKLDMEHFDRLTMLNREELLRVSSLLsqaiLEEPFSHNGKDYKEGDQIPKEEIASINRFTLASlVKKY 1031
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1023 DDEAAAQLEAIKNSIEEKRHQFDLAFEEKRKKLTQGDELPPGVLKMVKVYLAVKRRLQPGDKMAGRHGNKGVVSKIVPIE 1102
Cdd:PRK09603 1032 SKEVQNHYEITKNNFLEQKKVLGEEHEEKLSILEKDDILPNGVIKKVKLYIATKRKLKVGDKMAGRHGNKGIVSNIVPVA 1111
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1103 DMPYMADGRPADVVLNPLGVPSRMNVGQVLEVHLGWAAKGLGWRIGEMLQRQAK--IEELRVFLTKIYN-----ESGRQE 1175
Cdd:PRK09603 1112 DMPYTADGEPVDIVLNPLGVPSRMNIGQILEMHLGLVGKEFGKQIASMLEDKTKdfAKELRAKMLEIANainekDPLTIH 1191
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1176 DLESFTDEEILELAKNLREGVPFATPVFDGATEEEMGKMLDLAfpddiaqQLDMNpskNQVRLYDGRTGEQFERRVTLGY 1255
Cdd:PRK09603 1192 ALENCSDEELLEYAKDWSKGVKMAIPVFEGISQEKFYKLFELA-------KIAMD---GKMDLYDGRTGEKMRERVNVGY 1261
                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1256 MHYLKLHHLVDDKMHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGASYVLQEMLTVKSDDVTGRTKVYENLV 1335
Cdd:PRK09603 1262 MYMIKLHHLVDEKVHARSTGPYSLVTHQPVGGKALFGGQRFGEMEVWALEAYGAAHTLKEMLTIKSDDIRGRENAYRAIA 1341
                        1370      1380      1390
                  ....*....|....*....|....*....|
gi 500212820 1336 KGDHVIDAGMPESFNVLVKEIRSLGIDIDL 1365
Cdd:PRK09603 1342 KGEQVGESEIPETFYVLTKELQSLALDINI 1371
PRK14844 PRK14844
DNA-directed RNA polymerase subunit beta/beta';
27-1368 0e+00

DNA-directed RNA polymerase subunit beta/beta';


Pssm-ID: 173305 [Multi-domain]  Cd Length: 2836  Bit Score: 1413.61  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   27 LLATQLESFSTFlqadVPATQRKpEGLQAAFTSVFPIVSHNGFARLEFVSYALSSPAFNIKECQQRGLTYCSALRAKVRL 106
Cdd:PRK14844   32 LVKVQKESYDSF----TPKNKGN-ERLEVIFHTIFPINDPLHRATIEFISCRVDDPKYDESECIKRGITFSAQVIASIRL 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  107 VIL---------------DKESPNKPVVKEVKEQEVYMGEIPLMTPTGSFVINGTERVIVSQLHRSPGVFFEHDKGKTHS 171
Cdd:PRK14844  107 VIMqdgisldeyksikesGDHSKLATVIKSIEEQEVHFCELPMMTDKGTFIINGVEKVIVSQMHRSPGVFFDSDKGKTYN 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  172 SGKLLFSARIIPYRGSWLDFEFDPKDILYFRVDRRRKMPVTILLKAIGLTPEQILANFFVFDNFTLMDEGAQLEFVPERL 251
Cdd:PRK14844  187 SGKLIYSARVIPYRGSWLDIEFDVKDHLYFRIDRKRKLPISVLLKALGLSNNDILDRFYEKIKYIKHKDGWKVPFVPDKF 266
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  252 RGEVARFDITDRDGKVIVQKDKRINAKHIRDLEAAKTKFISVPEDYLLGRVLAKNVVDGDTGEVIASANDEVTESVLEKL 331
Cdd:PRK14844  267 KGVRLPFDLMDVEGNVLLKANVRITSRLAKKLYDNELKEYLVPFDSICGLFLAEDLIDSASSTKILSAGESIKLEDIKKL 346
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  332 REAGIKDIQTLYTNDLDQGPYISSTLRVDETTDRTAARIAIYRMMRPGEPPTEEAVEALFNRLFYSEEAYDLSKVGRMKF 411
Cdd:PRK14844  347 ELLSIDEISVLNIDNLSVGPYILNTLFLDENMSYQDALYEIYKVLRPGEVPVLEIVEEFFRNLFFSPEYYDLSNIGRLKL 426
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  412 NRRVGRDEIVGPMTLQDDDILATIKILVELRNGKGEVDDIDHLGNRRVRCVGELAENQFRAGLVRVERAVKERLGQAESE 491
Cdd:PRK14844  427 NSYLGLNYDEDLTVLTHEDIIEIVRKIVLLRDGQGSVDDIDHLGNRRVRSVGEFIENQFRTGLLKLERAVVDSMSTSSLD 506
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  492 NLMPHDLINSKPISSAIREFFGSSQLSQFMDQTNPLSEITHKRRVSALGPGGLTRERAGFEVRDVHPTHYGRVCPIETPE 571
Cdd:PRK14844  507 KVSPSDFINPKVLTNVLRDFFNSSQLSQFMDQTNPLSEITHKRRLSALGPGGLTRERAGFEVRDVHPTHYGRICPIETPE 586
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  572 GPNIGLINSLALYAHLNEYGFLETPYRKVVDSKVTDQIDYLSAIEEGRYMIAQANAAIDENGQLIDELVSSREAGETMMV 651
Cdd:PRK14844  587 GQNIGLINSLAIYARINKYGFIESPYRKVVNRVVTDQIEYLSAIDEGLYYIADTSAKLDENNCFVDDMLYCRYAGSFVMV 666
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  652 TPDRIQYMDVAPSQIVSVAASLIPFLEHDDANRALMGSNMQRQAVPCLRPEKPVVGTGIERTCAVDSGTTVQAFRGGVVD 731
Cdd:PRK14844  667 SSDQVSYIDVSPKQVISVAASLIPFLENDDANRALMGSNMQRQAVPLLKPTAPLVATGMESFVASGSGAVVLAKRDGIVD 746
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  732 YVDAGRIVIRVNDDEAVaGEVGVDIYNLIKYTRSNQNTNINQRPIVKMGDKVSRGDVLADGASTDLGELALGQNMLIAFM 811
Cdd:PRK14844  747 SSDSNSIVIRAFDKERV-NYLDVDIYHLRKFQRSNHNTCINQKPLVCVGDYVKEGDVIADGPAINSGELALGQNLLVAFM 825
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  812 PWNGYNFEDSILISEKVVADDRYTSIHIEELNVVARDTKLGPEEITRDISNLAEVQLGRLDESGIVYIGAEVEAGDVLVG 891
Cdd:PRK14844  826 SWQGYNFEDSIIISSEVVKKDLFTSIHIEEFECVVHDTPLGSEKITRAIPGVNEENLYHLDDSGIVKIGTRVGPGYILVG 905
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  892 KVTPKGETQLTPEEKLLRAIFGEKASDVKDTSLRVPSGMSGTVIDVQVFTREGIQRDKRAQQIIDDELKRYRLDLNDQLR 971
Cdd:PRK14844  906 KVTPKPSLSLPPETKLLMTIFGEKSFDCADSSLYTSPDVEGTVIDVQVFTRRGVEENERALLIKQKEINDFEKERDYIIN 985
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  972 IVEGDAFQRLARMLVgkvaNGGPKklakgtkiDQAYLEDLDHYHWFDIRLADDEAAAQLEAIKNSIEEKRHQFDLAFEEK 1051
Cdd:PRK14844  986 VTSEYFYDELKKLLI----NSGSQ--------DREKFDSIEREQWWGIGLKNQSISEQVKSLKKDFDEKVSHAIAQFKRK 1053
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1052 RKKLTQGDELPPGVLKMVKVYLAVKRRLQPGDKMAGRHGNKGVVSKIVPIEDMPYMADGRPADVVLNPLGVPSRMNVGQV 1131
Cdd:PRK14844 1054 VEKLHEGYDLPQGVSMSVKVFIAVKHSLQPGDKMAGRHGNKGVISRVVPVEDMPYLEDGTPVDIILNPLGVPSRMNVGQI 1133
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1132 LEVHLGWAAKGLGWRIGEMLQRQAKIEE---------------------------------------------------- 1159
Cdd:PRK14844 1134 LETHVGWACKKLGEKVGNILDEINKIKSafckgirslnddnftkfaaayldnkkienidddeitasvlntpnknalndel 1213
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1160 -----------------LRVFLTKIYNESGRQE---DLESFTDEEILELAKNLREGVPFATPVFDGATEEEMGKMLDLAf 1219
Cdd:PRK14844 1214 nelvenylnscksaysnLRNFLIEVYSCGSNVSicnNIRDISDNNLIEFARKLRDGIPVAAPVFEGPKDEQIAKLFELA- 1292
                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1220 pddiaqqlDMNPSkNQVRLYDGRTGEQFERRVTLGYMHYLKLHHLVDDKMHARSTGPYSLVTQQPLGGKAQFGGQRFGEM 1299
Cdd:PRK14844 1293 --------GLDNS-GQAVLYDGCSGEKFDRKVTVGYMYMLKLHHLVDGKIHARSVGPYSLVTQQPLGGKSHFGGQRFGEM 1363
                        1370      1380      1390      1400      1410      1420
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 500212820 1300 EVWALEAYGASYVLQEMLTVKSDDVTGRTKVYENLVKGDHVIDAGMPESFNVLVKEIRSLGIDIDLDRN 1368
Cdd:PRK14844 1364 ECWALQAYGAAYTLQEMLTVKSDDINGRVKIYESIIKGDSNFECGIPESFNVMIKELRSLCLNVDLKQN 1432
rpoB CHL00001
RNA polymerase beta subunit
25-1364 0e+00

RNA polymerase beta subunit


Pssm-ID: 214330 [Multi-domain]  Cd Length: 1070  Bit Score: 1076.84  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   25 PFLLATQLESFSTFLQadvpatqrkpEGLQAAFTSVFPIVSHNGFARLEFVS--YALSSPAFNIKECQQRGLTYCSALRA 102
Cdd:CHL00001   13 PGFNQIQFEGFCRFID----------QGLTEELSKFPKIEDTDQEIEFQLFVetYQLVEPLIKERDAVYESLTYSSELYV 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  103 KVRLVilDKESpnkpvvKEVKEQEVYMGEIPLMTPTGSFVINGTERVIVSQLHRSPGVFF--EHDKgkthsSGKLLFSAR 180
Cdd:CHL00001   83 PAGLI--WKKS------RDMQEQTVFIGNIPLMNSLGTFIINGIYRVVINQILRSPGIYYrsELDH-----NGISVYTGT 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  181 IIPYRGSWLDFEFDPKDILYFRVDRRRKMPVTILLKAIGLTPEQILANffvfdnftlmdegaqlefvperlrgevarfdi 260
Cdd:CHL00001  150 IISDWGGRLELEIDRKARIWARVSRKQKISILVLLSAMGLNLREILDN-------------------------------- 197
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  261 tdrdgkvivqkdkrinakhirdleaaktkfISVPEDYLlgrvlaknvvdgdtgeviasandevtESVLEKLREagikdiq 340
Cdd:CHL00001  198 ------------------------------VCYPEIFL--------------------------SFLNDKEKK------- 214
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  341 tlytndldqgpYISStlrvdettdRTAARIAIYRMM--RPGEPPTEEAV-EALFNRLFysEEAYDLSKVGRMKFNRR--- 414
Cdd:CHL00001  215 -----------KIGS---------KENAILEFYQQFacVGGDPVFSESLcKELQKKFF--QQRCELGRIGRRNMNRKlnl 272
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  415 -VGRDEIvgpmTLQDDDILATIKILVELRNGKGEVDDIDHLGNRRVRCVGELAENQFRAGLVRVERAVKERLGQAESENL 493
Cdd:CHL00001  273 dIPENNT----FLLPQDVLAAADYLIGMKFGMGTLDDIDHLKNKRIRSVADLLQDQFGLALNRLENAVRGTICGAIRRKL 348
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  494 M--PHDLINSKPISSAIREFFGSSQLSQFMDQTNPLSEITHKRRVSALGPGGLTRERAGFEVRDVHPTHYGRVCPIETPE 571
Cdd:CHL00001  349 IptPQNLVTSTPLTTTYESFFGSHPLSQFLDQTNPLTEIVHGRKLSSLGPGGLTGRTASFRVRDIHPSHYGRICPIDTSE 428
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  572 GPNIGLINSLALYAHLNEYGFLETPYRKVVDSKVTDQIDYLSAIEEGRYMIAQANAAIDENGQLIDELVSSREAGETMMV 651
Cdd:CHL00001  429 GINAGLIGSLAIHARIGHWGSLESPFYEISERSKEERMVYLSPSEDEYYMIAAGNSLALNQGIQEEQVVPARYRQEFLTI 508
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  652 TPDRIQYMDVAPSQIVSVAASLIPFLEHDDANRALMGSNMQRQAVPCLRPEKPVVGTGIERTCAVDSGTTVQAFRGGVVD 731
Cdd:CHL00001  509 AWEQIHLRSIFPFQYFSIGASLIPFLEHNDANRALMGSNMQRQAVPLSRSEKCIVGTGLERQVALDSGVVAIAEHEGKII 588
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  732 YVDAGRIVIRVNDDEavagevgvDIYNLIKYTRSNQNTNINQRPIVKMGDKVSRGDVLADGASTDLGELALGQNMLIAFM 811
Cdd:CHL00001  589 YTDTDKIILSGNGDT--------LSIPLVMYQRSNKNTCMHQKPQVRRGKCVKKGQILADGAATVGGELALGKNVLVAYM 660
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  812 PWNGYNFEDSILISEKVVADDRYTSIHIEELNVVARDTKLGPEEITRDISNLAEVQLGRLDESGIVYIGAEVEAGDVLVG 891
Cdd:CHL00001  661 PWEGYNFEDAVLISERLVYEDIYTSFHIRKYEIQTHVTSQGPERITKEIPHLEAHLLRNLDKNGIVMLGSWVETGDILVG 740
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  892 KVTPK--GETQLTPEEKLLRAIFGEKASDVKDTSLRVPSGMSGTVIDVQvftregiqrdkraqqiiddelkryrldlndq 969
Cdd:CHL00001  741 KLTPQeaEESSYAPEGRLLRAIFGIQVSTSKETCLKLPIGGRGRVIDVR------------------------------- 789
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  970 lrivegdafqrlarmlvgkvanggpkklakgtkidqayledldhyhWFdirladdeaaaqleaiknsieekrhqfdlafe 1049
Cdd:CHL00001  790 ----------------------------------------------WI-------------------------------- 791
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1050 ekrkkltQGDELPPGVLKMVKVYLAVKRRLQPGDKMAGRHGNKGVVSKIVPIEDMPYMADGRPADVVLNPLGVPSRMNVG 1129
Cdd:CHL00001  792 -------QKKGGSSYNPETIHVYILQKREIQVGDKVAGRHGNKGIISKILPRQDMPYLQDGTPVDMVLNPLGVPSRMNVG 864
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1130 QVLEVHLGWAakglgwriGEMLQRQAKIEElrvfltkiYNESGRQEDLESFTDEEILELAKnlREGVPFatpVFDgatee 1209
Cdd:CHL00001  865 QIFECLLGLA--------GDLLNRHYRIAP--------FDERYEQEASRKLVFSELYEASK--QTANPW---VFE----- 918
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1210 emgkmldlafPDdiaqqldmNPSKNqvRLYDGRTGEQFERRVTLGYMHYLKLHHLVDDKMHARSTGPYSLVTQQPLGGKA 1289
Cdd:CHL00001  919 ----------PE--------YPGKS--RLFDGRTGDPFEQPVTIGKAYILKLIHQVDDKIHARSSGPYALVTQQPLRGRS 978
                        1290      1300      1310      1320      1330      1340      1350
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 500212820 1290 QFGGQRFGEMEVWALEAYGASYVLQEMLTVKSDDVTGRTKVYENLVKGDHVIDA-GMPESFNVLVKEIRSLGIDID 1364
Cdd:CHL00001  979 KQGGQRVGEMEVWALEGFGVAYILQEMLTYKSDHIRARQEVLGAIITGGTIPKPeDAPESFRLLVRELRSLALELN 1054
rpoB CHL00207
RNA polymerase beta subunit; Provisional
23-1363 0e+00

RNA polymerase beta subunit; Provisional


Pssm-ID: 214397 [Multi-domain]  Cd Length: 1077  Bit Score: 1033.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   23 QVPFLLATQLESFSTFLQadvpatqrkpEGLQAAFTSVFPIVSHNGFARLEFVS--YALSSPAFNIKECQQRGLTYCSAL 100
Cdd:CHL00207    6 ALPDFLEIQRTSFCWFLN----------EGLNEELNIFSKIFDYTGNLELLLFGknYKLKYPKYNLLSAKSYDSNYSIQI 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  101 RAKVRLVILDKESpnkpvvkeVKEQEVYMGEIPLMTPTGSFVINGTERVIVSQLHRSPGVFFEHDKGKTHssgKLLFSAR 180
Cdd:CHL00207   76 YLPLKFINLKTNK--------IKFINYLIGNLPKMTQRGTFIINGLERVIVSQIIRSPGIYFKKEIKKNS---NKIYSAT 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  181 IIPYRGSWLDFEFDPKDILYFRVDRRRKMPVTILLKAIGLTPEQILANFFVFDNFtlmdegaqlefvperlrgevarfdi 260
Cdd:CHL00207  145 LIPNRGSWIKFELDKNKEIWIRIDKNRKKPLIIFLKALGLTDQDIYSRLTKSEFL------------------------- 199
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  261 tdrdgkvivqkdkrinakhirdleaaktkfisvpedyllgrvlaknvvdgdtgeviasandevtesvleklreagikdiq 340
Cdd:CHL00207      --------------------------------------------------------------------------------
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  341 tlytndldqgPYISSTLRVDETTDRTAARIAIYRMMRPGEPPT-EEAVEALFNRlFYSEEAYDLSKVGRMKFNRRVGRDE 419
Cdd:CHL00207  200 ----------KKLKPILLNSNSYTNEEILLEIYKNLSPIEPATvNDANQNLFSR-FFDPKNYDLGKVGRYKINNKLNLNI 268
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  420 IVGPMTLQDDDILATIKILVELRNGKGEVDDIDHLGNRRVRCVGELAENQFRAGLVRVERAVKERLGQAESENLMPHDLI 499
Cdd:CHL00207  269 PERVRNLTYEDILSIIDKLINLKINKGNFDDIDHLKNRRVRSVGELLQNQFRIGLKRLERILRNRMTICDIDSLSKFNLI 348
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  500 NSKPISSAIREFFGSSQLSQFMDQTNPLSEITHKRRVSALGPGGLTRERAGFEVRDVHPTHYGRVCPIETPEGPNIGLIN 579
Cdd:CHL00207  349 NPKPLIALIREFFGSSQLSQYMDQTNPLSELTHKRRISILGPGGLDKDRISFAVRDIHPSHYGRICPIETPEGPNCGLIG 428
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  580 SLALYAHLNEYGFLETPYRKVVDSKV--TDQIDYLSAIEEGRYMIAQANAAIDENGQLIDELVSSREAGETMMVTPDRIQ 657
Cdd:CHL00207  429 SLATNARINKFGFIETPFYKVINGKVkkFGNPIYLTADSEDLYRIAPNDINLNKNNYFKKNIIPVRYKQEFKTVNPSKVD 508
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  658 YMDVAPSQIVSVAASLIPFLEHDDANRALMGSNMQRQAVPCLRPEKPVVGTGIERTCAVDSGTTVQAFRGGVVDYVDAGR 737
Cdd:CHL00207  509 FIAISPIQVFSIAESLIPFLEHNDANRALMGSNMQRQAVPLLYPEKPIVGTGYEKQIALDSGMTIISLTEGIVVSVSAYK 588
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  738 IVIRVNDDEAVagevgvdIYNLIKYTRSNQNTNINQRPIVKMGDKVSRGDVLADGASTDLGELALGQNMLIAFMPWNGYN 817
Cdd:CHL00207  589 IIIQDDNNRYI-------HYYLQKYQRSNQNTCINYRPIVWVGEKINIGQILADGSDIDNSELALGQNVLVAYMPWEGYN 661
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  818 FEDSILISEKVVADDRYTSIHIEELNVVARDTKLGPEEITRDISNLAEVQLGRLDESGIVYIGAEVEAGDVLVGKVTPKG 897
Cdd:CHL00207  662 FEDAILINKRLVYEDLFTSIHIEKYEIELRQTKLGSEEITRNIPNVSEYSLKNLDENGIISIGSKVLAGDILVGKITPKG 741
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  898 ETQLTPEEKLLRAIFGEKASDVKDTSLRVPSGMSGTVIDVQVFTREgiqrdkraqqiiddelkryrldlndqlrivegda 977
Cdd:CHL00207  742 ESDQLPEGKLLRAIFGEKAKDVKDTSLRMPNGGYGRVIKVEIFSRS---------------------------------- 787
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  978 fqrlarmlvgkvanggpkklakgtkidqayledldhyhwfdirladdeaaaqleaiknsieekrhqfdlafeekrkkltQ 1057
Cdd:CHL00207  788 -------------------------------------------------------------------------------K 788
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1058 GDELPPGVLKMVKVYLAVKRRLQPGDKMAGRHGNKGVVSKIVPIEDMPYMADGRPADVVLNPLGVPSRMNVGQVLEVHLG 1137
Cdd:CHL00207  789 GDELKFGYYLKIRVFIAQIRKIQVGDKLAGRHGNKGIISRILPRQDMPYLPDGTPPDIILNPLGVPSRMNVGQLFECLLG 868
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1138 WAAKGLGWRI-----GEMLQRQAKieelRVFLTKIYNEsgrqedLESFTDEEILelaknlregVPFATPvfdgateeemG 1212
Cdd:CHL00207  869 LAGDNLNKRFkilpfDEMYGSEYS----RILINNKLNQ------ASIKNNEYWL---------FNSYHP----------G 919
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1213 KMLdlafpddiaqqldmnpsknqvrLYDGRTGEQFERRVTLGYMHYLKLHHLVDDKMHARSTGPYSLVTQQPLGGKAQFG 1292
Cdd:CHL00207  920 KMV----------------------LRDGRTGYKFKNPVTVGIAYMLKLIHLVDDKIHARTTGPYSLVTQQPLGGKAQHG 977
                        1290      1300      1310      1320      1330      1340      1350
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 500212820 1293 GQRFGEMEVWALEAYGASYVLQEMLTVKSDDVTGRTKVYENLVKGDHVIDAGMPESFNVLVKEIRSLGIDI 1363
Cdd:CHL00207  978 GQRFGEMEVWALEAFGAAYTLKELLTIKSDDMQGRNETLNAIVKGQPIPKPGTPESFKVLMRELQSLGLDI 1048
RNA_pol_B_RPB2 cd00653
RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. ...
27-1366 0e+00

RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase complex contains two related members of this family, in each case they are the two largest subunits.The clamp is a mobile structure that grips DNA during elongation.


Pssm-ID: 238353 [Multi-domain]  Cd Length: 866  Bit Score: 864.57  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   27 LLATQLESFSTFLQadvpatqrkpEGLQAAFTSVFPIVS--HNGFARLEFVSYALSSP---------AFNIKECQQRGLT 95
Cdd:cd00653     1 LVKQQIDSFNYFLN----------VGLQEIVKSIPPITDtdDDGRLKLKFGDIYLGKPkveeggvtrKLTPNECRLRDLT 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   96 YCSALRAKVRLVILDKEspnkpvvkEVKEQEVYMGEIPLMT------------------------PTGSFVINGTERVIV 151
Cdd:cd00653    71 YSAPLYVDIRLTVNDKG--------KIKEQEVFIGEIPIMLrsklcnlngltpeeliklgecpldPGGYFIINGTEKVII 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  152 SQLHRSPGVFFEHDkgkthSSGKLLFSARIIP----YRGSWLDFEFDpkdilyfrvdrrrkmpvtillkaigltpeqila 227
Cdd:cd00653   143 NQEQRSPNVIIVED-----SKGKRIYTKTSIPsyspYRGSWLEVKSD--------------------------------- 184
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  228 nffvfdnftlmdegaqlefvperlrgevarfditdrdgkvivQKDKRINAKHirdleaaktkfisvpedyllgrvlaknv 307
Cdd:cd00653   185 ------------------------------------------KKKDRIYVRI---------------------------- 194
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  308 vdgdtgeviasandevtesvleklreagikdiqtlytndldqgPYIsstlrvdettdrtaariaiyrmmrpgepPTEEAV 387
Cdd:cd00653   195 -------------------------------------------DLK----------------------------RQEEAL 203
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  388 EALFNRLFyseeaydlskvgrmkfnrrvgrdeivgpmtlqddDILATIKILVELRNGKGEVDDIDHLGNRRVRCVGELAE 467
Cdd:cd00653   204 KYIGKRFE----------------------------------DLIYMIRKLILLVLGKGKLDDIDHLGNKRVRLAGELLQ 249
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  468 NQFRAGLVRVERAVKERLGQAESEN--LMPHDLINSKPISSAIREFFGSSQ------------LSQFMDQTNPLSEITHK 533
Cdd:cd00653   250 NLFRSGLKRLEREVKEKLQKQLSKKkdLTPQLLINSKPITSGIKEFLATGNwgskrflmqrsgLSQVLDRLNPLSELSHK 329
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  534 RRVSAlgpGGLTRERAGFEVRDVHPTHYGRVCPIETPEGPNIGLINSLALYAHLNeyGFLETPYRKvVDSKVTdqidyls 613
Cdd:cd00653   330 RRISS---LGLFRERKGFEVRDLHPSHWGRICPIETPEGENCGLVKNLALMARIS--GRIERPYRI-VEKEVT------- 396
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  614 aieegrymiaqanaaidengqlidelvssreagetmmvtpdriqYMDVAPSQIVSVAASLIPFLEHDDANRALMGSNMQR 693
Cdd:cd00653   397 --------------------------------------------HIEISPSQILSVAASLIPFPEHNQSPRNLYQSNMQK 432
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  694 QAVP----------------CLRPEKPVVGTGIErtcavdsgttvqafrggvvdyvdagrivirvnddeavagevgvdiy 757
Cdd:cd00653   433 QAVGtpalnqqyrmdtklylLLYPQKPLVGTGIE---------------------------------------------- 466
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  758 NLIKYtrsnqntninqrpivkmgdkvsrgdvladgastdlGELALGQNMLIAFMPWNGYNFEDSILISEKVVADDRYTSI 837
Cdd:cd00653   467 EYIAF-----------------------------------GELPLGQNAIVAVMSYSGYNFEDAIIINKSSVDRGFFRSI 511
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  838 HIEELNVVARDTKLGPEEITR-DISNLAEVQLGRLDESGIVYIGAEVEAGDVLVGKVTPKGETQLTPeekllraIFGEKA 916
Cdd:cd00653   512 HYKKYEIELRKTKNGPEEITRgDIPNVSEEKLKNLDEDGIIRPGARVEPGDILVGKITPKGETESTP-------IFGEKA 584
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  917 SDVKDTSLRVPSGMSGTVIDVQVFTRegiqrdkraqqiiddelkryrldlndqlrivegdafqrlarmlvgkvanggpkk 996
Cdd:cd00653   585 RDVRDTSLKYPGGEKGIVDDVKIFSR------------------------------------------------------ 610
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  997 lakgtkidqayledldhyhwfdirladdeaaaqleaiknsieekrhqfdlafeekrkkltqgdELPPGVLKMVKVYLAVK 1076
Cdd:cd00653   611 ---------------------------------------------------------------ELNDGGNKLVKVYIRQK 627
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1077 RRLQPGDKMAGRHGNKGVVSKIVPIEDMPYMADGRPADVVLNPLGVPSRMNVGQVLEVHLGWAAKGLGWRIgemlqrqak 1156
Cdd:cd00653   628 RKPQIGDKFASRHGQKGVISKILPQEDMPFTEDGIPPDIILNPHGFPSRMTIGQLLESLLGKAGALLGKFG--------- 698
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1157 ieelrvfltkiynesgrqedlesftdeeilelaknlregvpFATPvFDGATEEEMGKMLDLAFPDdiaqqldmNPSKnqV 1236
Cdd:cd00653   699 -----------------------------------------DATP-FDGAEEEDISELLGEAGLN--------YYGK--E 726
                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1237 RLYDGRTGEQFERRVTLGYMHYLKLHHLVDDKMHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGASYVLQEM 1316
Cdd:cd00653   727 VLYDGRTGEPLEAPIFVGPVYYQRLKHMVDDKIHARSTGPYSLLTRQPLKGRSRGGGQRFGEMERDALIAHGAAYLLQER 806
                        1370      1380      1390      1400      1410      1420
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1317 LTVKSDDVTGRTKVYENLV----------KGDHVIDAGMPESFNVLVKEIRSLGIDIDLD 1366
Cdd:cd00653   807 LTIKSDDVVARVCVKCGIIlsanlcrlckKGTNISKVGIPYAFKLLFQELQSMNIDPRLK 866
RNA_pol_Rpb2_6 pfam00562
RNA polymerase Rpb2, domain 6; RNA polymerases catalyze the DNA dependent polymerization of ...
724-1290 1.86e-160

RNA polymerase Rpb2, domain 6; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain represents the hybrid binding domain and the wall domain. The hybrid binding domain binds the nascent RNA strand / template DNA strand in the Pol II transcription elongation complex. This domain contains the important structural motifs, switch 3 and the flap loop and binds an active site metal ion. This domain is also involved in binding to Rpb1 and Rpb3. Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 2 (DRII).


Pssm-ID: 459854 [Multi-domain]  Cd Length: 371  Bit Score: 486.27  E-value: 1.86e-160
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   724 AFRGGVVDYVDAGRIVIRVNDDEAVAGevgvdIYNLIKYTRSNQNT---NINQRPIVKMGdKVSRGDvladgastdLGEL 800
Cdd:pfam00562    2 ASLIPFVDHNQSPRNTYQCAMGKQAMG-----IYTLNKFYRSDQNTyvlCYPQKPLVKTG-AVEAGG---------FGEL 66
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   801 ALGQNMLIAFMPWNGYNFEDSILISEKVVADDRYTSIHIEElnVVARDTKLGP-EEITRDISNLAEVQLGRLDESGIVYI 879
Cdd:pfam00562   67 PLGQNAIVAVMSYTGYNQEDAIIINKSSVDRGFFTSIHIKE--IEARKTKLGPiEEITRDIPNVSEEALKKLDEDGIVRV 144
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   880 GAEVEAGDVLVGKVtpkGETQLTpeeKLLRAIFGEKASDVKDTSLRVPSGMSGTVIDVQVFTregiqrdkraqqiiddel 959
Cdd:pfam00562  145 GAEVKPGDILVGKV---GPTELT---KLLRAIFGEKARDVKDTSLKVPPGEEGVVDDVIVFE------------------ 200
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   960 kryrldlndqlrivegdafqrlarmlvgkvanggpkklakgtkidqayledldhyhwfdirladdeaaaqleaiknsiee 1039
Cdd:pfam00562      --------------------------------------------------------------------------------
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  1040 krhqfdlafeekrkkltqgdeLPPGVLKMVKVYLAVKRRLQPGDKMAGRHGNKGVVSKIVPIEDMPYMADGRPADVVLNP 1119
Cdd:pfam00562  201 ---------------------LPPGGIKMVKVYIRQKRKPEVGDKFASRHGQKGVVSRILPQEDMPFTEDGIPPDIILNP 259
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  1120 LGVPSRMNVGQVLEVHLGWAAKGLgwrigemlqrqakieelrvfltkiynesgrqedlesftdeeilelaknlreGVPFA 1199
Cdd:pfam00562  260 HGVPSRMTIGQLLETHLGKAAALL---------------------------------------------------GVFVD 288
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  1200 TPVFDGATEEemgkmldlafPDDIAQQLD---MNPSKNQVrLYDGRTGEQFERRVTLGYMHYLKLHHLVDDKMHARSTGP 1276
Cdd:pfam00562  289 ATPFDGASTE----------VEDIGELLEkagYNYYGKEV-LYDGRTGEPFEAPIFVGPIYYQKLKHMVDDKIHARSTGP 357
                          570
                   ....*....|....
gi 500212820  1277 YSLVTQQPLGGKAQ 1290
Cdd:pfam00562  358 YSLLTRQPLGGRAR 371
PRK08565 PRK08565
DNA-directed RNA polymerase subunit B; Provisional
88-1365 5.52e-86

DNA-directed RNA polymerase subunit B; Provisional


Pssm-ID: 236291 [Multi-domain]  Cd Length: 1103  Bit Score: 304.96  E-value: 5.52e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   88 ECQQRGLTYCSALRAKVRLVILDKEspnkpvvkeVKEQEVYMGEIPLMT------------------------PTGSFVI 143
Cdd:PRK08565   75 EARLRNLTYAAPLYLTMIPVENGIE---------YEPEEVKIGDLPIMVkskicplsglspdelieigedpkdPGGYFII 145
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  144 NGTERVIVSQLHRSPG---VffehDKGKTHSSGKllFSARIIPYRG---SWLDFEFDPKDILYFRVDR-RRKMPVTILLK 216
Cdd:PRK08565  146 NGSERVIVSQEDLAPNrvlV----DKGEAGSSIT--HTAKVISSRAgyrAQVTVERRKDGTIYVSFPAvPGKIPFVILMR 219
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  217 AIGLTpeqilanffvfdnftlmdegaqlefvperlrgevarfdiTDRDGKVIVQKDKRINAKHIRDLEAAKTKFISVPE- 295
Cdd:PRK08565  220 ALGLE---------------------------------------TDRDIVYAVSLDPEIQQELLPSLEQASSIAATVEDa 260
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  296 -DYLLGRVlaknvvdgdtgeviasandevtesVLEKLREAGIKDIQTLytndLDQG--PYIsstlrvdettdrtaariai 372
Cdd:PRK08565  261 lDYIGKRV------------------------AIGQPREYRIERAEQI----LDKYllPHL------------------- 293
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  373 yrmmrpGEPPTEEAVEALFnrlfyseeaydlskVGRMkfnrrvgrdeivgpmtlqdddilatIKILVELRNGKGEVDDID 452
Cdd:PRK08565  294 ------GTSPEDRIKKAYF--------------LGQM-------------------------ASKLLELYLGRREPDDKD 328
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  453 HLGNRRVRCVGELAENQFRAGLVRVERAVKERLGQAESENLMPH--DLINSKPISSAIREFF-------GSSQLSQFMDQ 523
Cdd:PRK08565  329 HYANKRLRLAGDLLAELFRVAFKQLVKDLKYQLEKSYARGRKLDlrAIVRPDIITERIRHALatgnwvgGRTGVSQLLDR 408
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  524 TNPLSEITHKRRVsaLGPggLTRERAGFEVRDVHPTHYGRVCPIETPEGPNIGLINSLALYAHL----NEYGFLETPYRK 599
Cdd:PRK08565  409 TNYLSTLSHLRRV--VSP--LSRGQPHFEARDLHGTQWGRICPFETPEGPNCGLVKNLALMAQIsvgvDEEEVEEILYEL 484
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  600 -VVDSKVTDQIDYLSA------------IEEGRYMIA-------------QANAAIDENGQlIDELVSSREAGETM---- 649
Cdd:PRK08565  485 gVVPVEEAREEEYISWsrvylngrligyHPDGEELAEkirelrrsgkisdEVNVAYIETGE-INEVYVNCDSGRVRrpli 563
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  650 -------MVTPDRIQ-------------------------------------------YMDVAPSQIVSVAASLIPFLEH 679
Cdd:PRK08565  564 vvengkpKLTREHVEklkkgeltfddlvkmgvieyldaeeeenayvaldpedltpehtHLEIWPPAILGITASIIPYPEH 643
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  680 DDANRALMGSNMQRQAVpclrpekpvvgtgiertcavdsGTTVQAFRggvvdyvdagrivIRVnDDEAvagevgvdiyNL 759
Cdd:PRK08565  644 NQSPRNTYQAAMAKQSL----------------------GLYAANFR-------------IRT-DTRG----------HL 677
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  760 IKYTrsnqntninQRPIVKmgdkvSRG-DVLAdgastdLGELALGQNMLIAFMPWNGYNFEDSILISEKVVadDR----- 833
Cdd:PRK08565  678 LHYP---------QRPLVQ-----TRAlEIIG------YNDRPAGQNAVVAVLSYTGYNIEDAIIMNKASI--ERglars 735
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  834 -----YTSihiEELNVV--ARDTKLGPEEITRDIsnLAEVQLGRLDESGIVYIGAEVEAGDVLVGKVTPKgetQLTPEEK 906
Cdd:PRK08565  736 tffrtYET---EERKYPggQEDKIEIPEPNVRGY--RGEEYYRKLDEDGIVSPEVEVKGGDVLIGKTSPP---RFLEELE 807
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  907 LLRAIFGEKasdvKDTSLRVPSGMSGTVIDVQVFTREgiqrdkraqqiiddelkryrldlndqlrivEGDafqrlarmlv 986
Cdd:PRK08565  808 ELSLGLQER----RDTSVTVRHGEKGIVDTVLITESP------------------------------EGN---------- 843
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  987 gkvanggpkklakgtkidqayledldhyhwfdirladdeaaaqleaiknsieekrhqfdlafeekrkkltqgdelppgvl 1066
Cdd:PRK08565      --------------------------------------------------------------------------------
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1067 KMVKVYLAVKRRLQPGDKMAGRHGNKGVVSKIVPIEDMPYMADGRPADVVLNPLGVPSRMNVGQVLEVhlgwaakglgwr 1146
Cdd:PRK08565  844 KLVKVRVRDLRIPELGDKFASRHGQKGVIGMLVPQEDMPFTEDGIVPDLIINPHAIPSRMTVGQLLES------------ 911
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1147 IGemlqrqAKIEELRvfltkiynesGRQEDlesftdeeilelaknlregvpfATPvFDGATEEEMGKMLD-LAFPddiaq 1225
Cdd:PRK08565  912 IA------GKVAALE----------GRFVD----------------------ATP-FYGEPEEELRKELLkLGYK----- 947
                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1226 qldmnPSKNQVrLYDGRTGEQFERRVTLGYMHYLKLHHLVDDKMHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALE 1305
Cdd:PRK08565  948 -----PDGTEV-MYDGRTGEKIKAPIFIGVVYYQKLHHMVADKIHARARGPVQILTRQPTEGRAREGGLRFGEMERDCLI 1021
                        1370      1380      1390      1400      1410      1420      1430
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 500212820 1306 AYGASYVLQEMLTVKSDDVT--------------GRTKVYENLVKGDH-----VIdagMPESFNVLVKEIRSLGIDIDL 1365
Cdd:PRK08565 1022 GHGAAMLLKERLLDSSDKTTiyvcelcghiawydRRKNKYVCPIHGDKgnispVE---VSYAFKLLLQELMSMGISPRL 1097
RNA_pol_Rpb2_1 pfam04563
RNA polymerase beta subunit; RNA polymerases catalyze the DNA dependent polymerization of RNA. ...
27-506 1.49e-68

RNA polymerase beta subunit; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain forms one of the two distinctive lobes of the Rpb2 structure. This domain is also known as the protrusion domain. The other lobe (pfam04561) is nested within this domain.


Pssm-ID: 367994 [Multi-domain]  Cd Length: 396  Bit Score: 236.51  E-value: 1.49e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820    27 LLATQLESFSTFLQADVPATQRKPEGLQAAFTSVFPIVSHNGFArLEFVSYALSSPAFN----------IKECQQRGLTY 96
Cdd:pfam04563    2 LVRQQLDSFNEFVDNDLQKIIDENALIESEFEIQHPGENGDKLS-LKFGQIRLGKPMFDetdgstreiyPQECRLRNLTY 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820    97 CSALRAKVRLVILDKEspnkpvvkEVKEQEVYMGEIPLMT------------------------PTGSFVINGTERVIVS 152
Cdd:pfam04563   81 SAPLYVDLELSVYNGE--------DIKPIEVFIGRLPIMLrsnacilsgateselvklgecpldPGGYFIINGSEKVIVA 152
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   153 QLHRS---PGVFFEHDKGKTHSSGKLLFSARI--IPYRGSWLDF-EFDPKDILYFRVDRRRK-MPVTILLKAIGLTPEQI 225
Cdd:pfam04563  153 QEHRSrnhPIVFKKADPKKRGSVASVRSSAEIsvRPDSTSWVNVlEYLSNGTIYFKFPYIKKeIPIVIILRALGFTSDRE 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   226 LANFFVFD-NFTLMDEgaqlEFVPERLrgEVARFDITDRDgkvivqkdkrinakhirdleaaktkfisVPEDYLLGRVla 304
Cdd:pfam04563  233 IFELICYDvNDQQLQE----ELLPSLE--EGFKIRIQTQE----------------------------QALDYIGGRG-- 276
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   305 knvvdgdtgeviasandevtesvleklreagikdiqtlytndldqgpyisstlrvdettdrtaarIAIYRMMRPGEPPTE 384
Cdd:pfam04563  277 -----------------------------------------------------------------RAIFRMGRPREPRIK 291
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   385 EAVEALFNRLFYSEEAYDLSKVGRMKFnrrvgrdeivgpmtlqdddILATIKILVELRNGKGEVDDIDHLGNRRVRCVGE 464
Cdd:pfam04563  292 YAEEILQKEVLPHLGTYELDETKKAYF-------------------IGYMIRRLLLLALGRREVDDRDHLGNKRLRLAGP 352
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....
gi 500212820   465 LAENQFRAGLVRVERAVKERLGQA--ESENLMPHDLINSKPISS 506
Cdd:pfam04563  353 LLASLFRVLFKKLVRDVRERLQKVlgSPDDLMLQLLVNAKPITS 396
rpoB_arch TIGR03670
DNA-directed RNA polymerase subunit B; This model represents the archaeal version of ...
609-1365 4.51e-56

DNA-directed RNA polymerase subunit B; This model represents the archaeal version of DNA-directed RNA polymerase subunit B (rpoB) and is observed in all archaeal genomes.


Pssm-ID: 274713 [Multi-domain]  Cd Length: 599  Bit Score: 206.03  E-value: 4.51e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   609 IDYLSAIEEgrymiaqANAAIdenGQLIDELvssreagetmmvTPDRiQYMDVAPSQIVSVAASLIPFLEHDDANRALMG 688
Cdd:TIGR03670   92 IEYLDAEEE-------ENAYI---ALDPEEL------------TPEH-THLEIDPSAILGIIASTIPYPEHNQSPRNTMG 148
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   689 SNMQRQAVpclrpekpvvgtgiertcavdsGTTVQAFRggvvdyvdagrivIRVNDDEavagevgvdiyNLIKYTrsnqn 768
Cdd:TIGR03670  149 AAMAKQSL----------------------GLYAANYR-------------IRLDTRG-----------HLLHYP----- 177
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   769 tninQRPIVKmgdkvSRGDVLadgasTDLGELALGQNMLIAFMPWNGYNFEDSILISEKVVADDRYTSIHIEELNVVARD 848
Cdd:TIGR03670  178 ----QKPLVK-----TRVLEL-----IGYDDRPAGQNFVVAVMSYEGYNIEDALIMNKASIERGLARSTFFRTYEAEERR 243
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   849 TKLG-------PEEITRDISnlAEVQLGRLDESGIVYIGAEVEAGDVLVGKVTPkgetqltP---EEkllRAIFGEKASD 918
Cdd:TIGR03670  244 YPGGqedrfeiPEPDVRGYR--GEEAYKHLDEDGIVYPEVEVKGGDVLIGKTSP-------PrflEE---LREFGLVTER 311
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   919 VKDTSLRVPSGMSGtVIDvQVFTREGIQRDKraqqiiddelkryrldlndqlrivegdafqrlarmlvgkvanggpkkla 998
Cdd:TIGR03670  312 RRDTSVTVRHGEKG-IVD-KVIITETEEGNK------------------------------------------------- 340
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   999 kgtkidqayledldhyhwfdirladdeaaaqleaiknsieekrhqfdlafeekrkkltqgdelppgvlkMVKVYLAVKRR 1078
Cdd:TIGR03670  341 ---------------------------------------------------------------------LVKVRVRDLRI 351
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  1079 LQPGDKMAGRHGNKGVVSKIVPIEDMPYMADGRPADVVLNPLGVPSRMNVGQVLEVhlgwaakgLGWRIGEMlqrqakie 1158
Cdd:TIGR03670  352 PELGDKFASRHGQKGVIGMIVPQEDMPFTEDGIVPDLIINPHAIPSRMTVGQLLEM--------IAGKVAAL-------- 415
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  1159 elrvfltkiyneSGRQEDlesftdeeilelaknlregvpfATPvFDGATEEEMGKMLdlafpddiaQQLDMNPSKNQVrL 1238
Cdd:TIGR03670  416 ------------EGRRVD----------------------GTP-FEGEPEEELRKEL---------LKLGFKPDGKEV-M 450
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  1239 YDGRTGEQFERRVTLGYMHYLKLHHLVDDKMHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGASYVLQEMLT 1318
Cdd:TIGR03670  451 YDGITGEKLEAEIFIGVIYYQKLHHMVADKIHARSRGPVQVLTRQPTEGRAREGGLRFGEMERDVLIGHGAAMLLKERLL 530
                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 500212820  1319 VKSDDVT--------------GRTKVYENLVKGDHVIDAG--MPESFNVLVKEIRSLGIDIDL 1365
Cdd:TIGR03670  531 DESDKYVvyvcencghiawedKRKGTAYCPVCGETGDISPveMSYAFKLLLDELKSLGISPRL 593
PRK07225 PRK07225
DNA-directed RNA polymerase subunit B'; Validated
609-1362 6.26e-49

DNA-directed RNA polymerase subunit B'; Validated


Pssm-ID: 235972 [Multi-domain]  Cd Length: 605  Bit Score: 185.16  E-value: 6.26e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  609 IDYLSAIEEgrymiAQANAAIDEngqliDELvssreagetmmvTPDRiQYMDVAPSQIVSVAASLIPFLEHDDANRALMG 688
Cdd:PRK07225   98 IEYLDAEEE-----ENAYIAVYE-----EDL------------TEEH-THLEIDPSLILGIGAGMIPYPEHNASPRITMG 154
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  689 SNMQRQA--VPC----LRPEKpvvgtgiertcavdsgttvqafRGGVVDYVdagrivirvnddeavagevgvdiynliky 762
Cdd:PRK07225  155 AGMIKQSlgLPAanykLRPDT----------------------RGHLLHYP----------------------------- 183
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  763 trsnqntninQRPIVKMgdKVSRgdvladgaSTDLGELALGQNMLIAFMPWNGYNFEDSILISEKVVADDRYTSIHIEEL 842
Cdd:PRK07225  184 ----------QVPLVKT--QTQE--------IIGFDERPAGQNFVVAVMSYEGYNIEDALIMNKASIERGLGRSHFFRTY 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  843 NVVARDTKLGPE---EITRDisnlaEVQLGR-------LDESGIVYIGAEVEAGDVLVGKVTPkgetqltP---EEKllr 909
Cdd:PRK07225  244 EGEERRYPGGQEdrfEIPDK-----DVRGYRgeeayrhLDEDGLVNPETEVKEGDVLIGKTSP-------PrflEEP--- 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  910 AIFGEKASDVKDTSLRVPSGMSGTVidvqvftregiqrdkraqqiiddelkryrldlnDQLRIVEGDAFQRLARMLVgkv 989
Cdd:PRK07225  309 DDFGISPEKRRETSVTMRSGEEGIV---------------------------------DTVILTETEEGSRLVKVRV--- 352
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  990 anggpkklakgtkidqayledldhyhwfdirladdeaaaqleaiknsieekrhqfdlafeekRkkltqgDELPPGVlkmv 1069
Cdd:PRK07225  353 --------------------------------------------------------------R------DLRIPEL---- 360
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1070 kvylavkrrlqpGDKMAGRHGNKGVVSKIVPIEDMPYMADGRPADVVLNPLGVPSRMNVGQVLEvhlgwaakGLGWRIGE 1149
Cdd:PRK07225  361 ------------GDKFASRHGQKGVIGLIVPQEDMPFTESGVVPDLIINPHAIPSRMTVGHVLE--------MIGGKVGS 420
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1150 MlqrqakieelrvfltkiyneSGRQEDLESFTDEEILELAKNLRE-GvpfatpvFDGATEEEMgkmldlafpddiaqqld 1228
Cdd:PRK07225  421 L--------------------EGRRVDGTAFSGEDEEDLREALEKlG-------FEHTGKEVM----------------- 456
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1229 mnpsknqvrlYDGRTGEQFERRVTLGYMHYLKLHHLVDDKMHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYG 1308
Cdd:PRK07225  457 ----------YDGITGEKIEAEIFVGVIYYQKLHHMVANKLHARSRGPVQVLTRQPTEGRAREGGLRFGEMERDVLIGHG 526
                         730       740       750       760       770       780       790
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820 1309 ASYVLQEMLTVKSDDVT-------GRTKVYEN-------LVKGD--HVIDAGMPESFNVLVKEIRSLGID 1362
Cdd:PRK07225  527 AAMLLKERLLDESDKVEiyvcakcGMIAIYDKkrnrkycPICGEetDIYPVEMSYAFKLLLDELKSLGIA 596
RNA_pol_Rpb2_3 pfam04565
RNA polymerase Rpb2, domain 3; RNA polymerases catalyze the DNA dependent polymerization of ...
519-586 7.73e-38

RNA polymerase Rpb2, domain 3; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Domain 3, s also known as the fork domain and is proximal to catalytic site.


Pssm-ID: 428011 [Multi-domain]  Cd Length: 67  Bit Score: 135.73  E-value: 7.73e-38
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 500212820   519 QFMDQTNPLSEITHKRRVSAlGPGGLTRERAGFEVRDVHPTHYGRVCPIETPEGPNIGLINSLALYAH 586
Cdd:pfam04565    1 QVLDRTNYLSTLSHLRRVNS-PRGGLFREMKTTEVRDLHPSHWGRICPVETPEGPNCGLVKHLALYAR 67
RNA_pol_Rpb2_45 pfam10385
RNA polymerase beta subunit external 1 domain; RNA polymerases catalyze the DNA-dependent ...
597-662 4.09e-32

RNA polymerase beta subunit external 1 domain; RNA polymerases catalyze the DNA-dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared with three in eukaryotes (not including mitochondrial or chloroplast polymerases). This domain in prokaryotes spans the gap between domains 4 and 5 of the yeast protein. It is also known as the external 1 region of the polymerase and is bound in association with the external 2 region.


Pssm-ID: 463067 [Multi-domain]  Cd Length: 66  Bit Score: 119.39  E-value: 4.09e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 500212820   597 YRKVVDSKVTDQIDYLSAIEEGRYMIAQANAAIDENGQLIDELVSSREAGETMMVTPDRIQYMDVA 662
Cdd:pfam10385    1 YRKVEDGKVTDEIVYLTADEEDGYVIAQANAPLDEDGRFVDERVSARYRGEFPLVPPEEVDYMDVS 66
RNA_pol_Rpb2_7 pfam04560
RNA polymerase Rpb2, domain 7; RNA polymerases catalyze the DNA dependent polymerization of ...
1292-1366 8.75e-31

RNA polymerase Rpb2, domain 7; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Rpb2 is the second largest subunit of the RNA polymerase. This domain comprised of the structural domains anchor and clamp. The clamp region (C-terminal) contains a zinc-binding motif. The clamp region is named due to its interaction with the clamp domain found in Rpb1. The domain also contains a region termed "switch 4". The switches within the polymerase are thought to signal different stages of transcription.


Pssm-ID: 461355 [Multi-domain]  Cd Length: 87  Bit Score: 116.53  E-value: 8.75e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  1292 GGQRFGEMEVWALEAYGASYVLQEMLTVKSD----DVTGRTKVYEN-----LVKGDHVIDAG-MPESFNVLVKEIRSLGI 1361
Cdd:pfam04560    1 GGLRFGEMERWALIAYGAAHTLQERLTIKSDayevDVCGRCGLYAAynkcpICKGETDISPGyIPESFKLLFQELQSLGI 80

                   ....*
gi 500212820  1362 DIDLD 1366
Cdd:pfam04560   81 DPRLL 85
PRK09606 PRK09606
DNA-directed RNA polymerase subunit B''; Validated
438-589 1.29e-24

DNA-directed RNA polymerase subunit B''; Validated


Pssm-ID: 236587 [Multi-domain]  Cd Length: 494  Bit Score: 109.65  E-value: 1.29e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  438 LVELRNGKGEVDDIDHLGNRRVRCVGELAENQFRAGLVRVERAVKERLGQAESENLMPHdlinskpISSAIRE------- 510
Cdd:PRK09606  317 CFELALGRREEDDKDHYANKRLKLAGDLMEDLFRVAFNRLARDVKYQLERANMRNRELS-------IKTAVRSdvlterl 389
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820  511 ---------FFGSSQLSQFMDQTNPLSEITHKRRVSAlgpgGLTRERAGFEVRDVHPTHYGRVCPIETPEGPNIGLINSL 581
Cdd:PRK09606  390 ehamatgnwVGGRTGVSQLLDRTDYMATLSHLRRVVS----PLSRSQPHFEARDLHPTQWGRICPSETPEGPNCGLVKNF 465

                  ....*...
gi 500212820  582 ALYAHLNE 589
Cdd:PRK09606  466 AQMVEIST 473
RNA_pol_Rpb2_2 pfam04561
RNA polymerase Rpb2, domain 2; RNA polymerases catalyze the DNA dependent polymerization of ...
156-460 1.72e-11

RNA polymerase Rpb2, domain 2; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Rpb2 is the second largest subunit of the RNA polymerase. This domain forms one of the two distinctive lobes of the Rpb2 structure. This domain is also known as the lobe domain. DNA has been demonstrated to bind to the concave surface of the lobe domain, and plays a role in maintaining the transcription bubble. Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 1 (DRI).


Pssm-ID: 398318 [Multi-domain]  Cd Length: 185  Bit Score: 64.68  E-value: 1.72e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   156 RSPGVFF--EHDKGKTHSSgkllFSARIIPYRGSWLDFEFDPKDILYFRVDRRRKMPVTILLKAIGLtpeqilanffvfd 233
Cdd:pfam04561    1 RSNGIYVekELDKNGIIAT----YTSSLISNRGSWLKLEIDGKTLIWSRPSKKRKIPIVIFLKALGL------------- 63
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   234 nftlmdegaqlefvperlrgevarfdITDRDgkvIVQkdkrinakHIRDLeaaktkfisvPEDYLLgrvlaknvvdgdtg 313
Cdd:pfam04561   64 --------------------------VSDRE---ILD--------RLCYD----------FNDPQM-------------- 82
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500212820   314 eviasaNDEVTESVLEKLreagikDIQTLyTNDLDqgpYISSTLRvdettdrtaariaiyrmMRPGEPPTEEavealfnr 393
Cdd:pfam04561   83 ------LELLKPELEEAE------NIYTQ-EEALD---YIGKGFA-----------------LRRGEEPRLQ-------- 121
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 500212820   394 lfYSEEAYDlSKVGRMKFNRRVGRDEIVGPMTLQDDDILATIKILVELRNGKGEVDDIDHLGNRRVR 460
Cdd:pfam04561  122 --RAREILY-SRDPKYNLNKHLGLNEPFENERLKAQDILYMIDRLLNLKLGRRKPDDIDHLGNKRVR 185
PRK00566 PRK00566
DNA-directed RNA polymerase subunit beta'; Provisional
295-339 2.21e-08

DNA-directed RNA polymerase subunit beta'; Provisional


Pssm-ID: 234794 [Multi-domain]  Cd Length: 1156  Bit Score: 58.93  E-value: 2.21e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 500212820  295 EDYLLGRVLAKNVVDGDTGEVIASANDEVTESVLEKLREAGIKDI 339
Cdd:PRK00566  803 EERILGRVLAEDVVDPETGEVIVPAGTLIDEEIADKIEEAGIEEV 847
rpoC2 PRK02597
DNA-directed RNA polymerase subunit beta'; Provisional
295-339 1.59e-04

DNA-directed RNA polymerase subunit beta'; Provisional


Pssm-ID: 235052 [Multi-domain]  Cd Length: 1331  Bit Score: 46.53  E-value: 1.59e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 500212820  295 EDYLLGRVLAKNVVDGDtGEVIASANDEVTESVLEKLREAGIKDI 339
Cdd:PRK02597  236 GDRLLGRVLAEDVVDPE-GEVIAERNTAIDPDLAKKIEKAGVEEV 279
RpoC COG0086
DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; DNA-directed RNA ...
295-340 5.13e-04

DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; DNA-directed RNA polymerase, beta' subunit/160 kD subunit is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 439856 [Multi-domain]  Cd Length: 1165  Bit Score: 44.77  E-value: 5.13e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 500212820  295 EDYLLGRVLAKNVVDGDTGEVIASANDEVTESVLEKLREAGIKDIQ 340
Cdd:COG0086   802 KERILGRVAAEDVVDPGTGEVLVPAGTLIDEEVAEIIEEAGIDSVK 847
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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