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Conserved domains on  [gi|500137526|ref|WP_011813531|]
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ornithine carbamoyltransferase [Halorhodospira halophila]

Protein Classification

ornithine carbamoyltransferase( domain architecture ID 11479232)

ornithine carbamoyltransferase reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to L-ornithine (ORN) to produce L-citrulline, as part of the urea cycle and L-arginine biosynthesis

CATH:  3.40.50.720
EC:  2.1.3.3
Gene Ontology:  GO:0004585|GO:0006591|GO:0006526
PubMed:  18062991

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK00779 PRK00779
ornithine carbamoyltransferase; Provisional
 1-297 0e+00

ornithine carbamoyltransferase; Provisional


:

Pssm-ID: 234835 [Multi-domain]  Cd Length: 304  Bit Score: 569.34  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526   1 MRHFLTLRDCSVDEIHQLLRRATELRDMHRAGHLHQPLQGRVLGMVFEKSSTRTRVSFEAGMAQLGGHALFLSPRDTQLG 80
Cdd:PRK00779   4 GRHFLSLDDLSPEELEELLDLAAELKKKRKAGEPHPPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIFLSPRDTQLG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526  81 RGEPVEDTARVVSRMVDAVMIRTFGHDMLERFAGHSAAPVINGLSDLCHPCQLLADLQTFTEHRGPITDRRVAWIGDGNN 160
Cdd:PRK00779  84 RGEPIEDTARVLSRYVDAIMIRTFEHETLEELAEYSTVPVINGLTDLSHPCQILADLLTIYEHRGSLKGLKVAWVGDGNN 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526 161 MCHSWIEAAGLLGFDLHIAAPPGYRPEADILALG----GDRVQVFDDAYAAAEGADLVTTDVWASMGQESEQAAREEAFR 236
Cdd:PRK00779 164 VANSLLLAAALLGFDLRVATPKGYEPDPEIVEKIaketGASIEVTHDPKEAVKGADVVYTDVWVSMGQEAEAEERLKAFA 243

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 500137526 237 GFCVTESLMECAGEQALFMHCLPAHRGEEVEAAVLEGPQSVVWDEAENRLHAQKALLEFLM 297
Cdd:PRK00779 244 PYQVNEELMALAKPDAIFMHCLPAHRGEEVTDEVIDGPQSVVWDEAENRLHAQKALLAWLL 304
 
Name Accession Description Interval E-value
PRK00779 PRK00779
ornithine carbamoyltransferase; Provisional
 1-297 0e+00

ornithine carbamoyltransferase; Provisional


Pssm-ID: 234835 [Multi-domain]  Cd Length: 304  Bit Score: 569.34  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526   1 MRHFLTLRDCSVDEIHQLLRRATELRDMHRAGHLHQPLQGRVLGMVFEKSSTRTRVSFEAGMAQLGGHALFLSPRDTQLG 80
Cdd:PRK00779   4 GRHFLSLDDLSPEELEELLDLAAELKKKRKAGEPHPPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIFLSPRDTQLG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526  81 RGEPVEDTARVVSRMVDAVMIRTFGHDMLERFAGHSAAPVINGLSDLCHPCQLLADLQTFTEHRGPITDRRVAWIGDGNN 160
Cdd:PRK00779  84 RGEPIEDTARVLSRYVDAIMIRTFEHETLEELAEYSTVPVINGLTDLSHPCQILADLLTIYEHRGSLKGLKVAWVGDGNN 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526 161 MCHSWIEAAGLLGFDLHIAAPPGYRPEADILALG----GDRVQVFDDAYAAAEGADLVTTDVWASMGQESEQAAREEAFR 236
Cdd:PRK00779 164 VANSLLLAAALLGFDLRVATPKGYEPDPEIVEKIaketGASIEVTHDPKEAVKGADVVYTDVWVSMGQEAEAEERLKAFA 243

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 500137526 237 GFCVTESLMECAGEQALFMHCLPAHRGEEVEAAVLEGPQSVVWDEAENRLHAQKALLEFLM 297
Cdd:PRK00779 244 PYQVNEELMALAKPDAIFMHCLPAHRGEEVTDEVIDGPQSVVWDEAENRLHAQKALLAWLL 304
ArgF COG0078
Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine ...
 1-299 0e+00

Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine carbamoyltransferase is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 439848 [Multi-domain]  Cd Length: 310  Bit Score: 536.94  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526   1 MRHFLTLRDCSVDEIHQLLRRATELRDMHRAGHLHQPLQGRVLGMVFEKSSTRTRVSFEAGMAQLGGHALFLSPRDTQLG 80
Cdd:COG0078    5 GRHFLSLLDLTPEELRALLDLAAELKAKRKAGIPHRPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIYLDPGDSQLG 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526  81 RGEPVEDTARVVSRMVDAVMIRTFGHDMLERFAGHSAAPVINGLSDLCHPCQLLADLQTFTEHRGPITDRRVAWIGDGNN 160
Cdd:COG0078   85 RGESIKDTARVLSRYVDGIMIRTFGHETLEELAKYAGVPVINGLTDLFHPCQALADLLTIREHFGKLKGLKVAYVGDGNN 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526 161 MCHSWIEAAGLLGFDLHIAAPPGYRPEADILAL-------GGDRVQVFDDAYAAAEGADLVTTDVWASMGQESEQAAREE 233
Cdd:COG0078  165 VANSLLLAAAKLGMDVRIATPEGYEPDPEIVAKakeiaaeSGGSITITHDPAEAVKGADVVYTDVWVSMGQEEEAEERIK 244

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 500137526 234 AFRGFCVTESLMECAGEQALFMHCLPAHRGEEVEAAVLEGPQSVVWDEAENRLHAQKALLEFLMLG 299
Cdd:COG0078  245 AFKPYQVNEELMALAKPDAIFMHCLPAHRGEEVTDEVIDGPQSVVFDEAENRLHAQKALLAWLLGG 310
orni_carb_tr TIGR00658
ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in ...
 2-297 1.71e-148

ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in a superfamily with the related enzyme aspartate carbamoyltransferase. Most known examples are anabolic, playing a role in arginine biosynthesis, but some are catabolic. Most OTCases are homotrimers, but the homotrimers are organized into dodecamers built from four trimers in at least two species; the catabolic OTCase of Pseudomonas aeruginosa is allosterically regulated, while OTCase of the extreme thermophile Pyrococcus furiosus shows both allostery and thermophily. [Amino acid biosynthesis, Glutamate family]


Pssm-ID: 129743 [Multi-domain]  Cd Length: 304  Bit Score: 418.68  E-value: 1.71e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526    2 RHFLTLRDCSVDEIHQLLRRATELRDMHRAGHLHQPLQGRVLGMVFEKSSTRTRVSFEAGMAQLGGHALFLSPRDTQLGR 81
Cdd:TIGR00658   1 RHLLSLLDLSPEEIRYLLQLAKKLKKGKKKGKEHKKLKGKTLALIFEKPSTRTRVSFEVAAYQLGGHPLYLNPNDLQLGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526   82 GEPVEDTARVVSRMVDAVMIRTFGHDMLERFAGHSAAPVINGLSDLCHPCQLLADLQTFTEHRGPITDRRVAWIGDGNNM 161
Cdd:TIGR00658  81 GESIKDTARVLSRYVDGIMARVYKHEDVEELAKYASVPVINGLTDLFHPCQALADLLTIIEHFGKLKGVKVVYVGDGNNV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526  162 CHSWIEAAGLLGFDLHIAAPPGYRPEADIL-------ALGGDRVQVFDDAYAAAEGADLVTTDVWASMGQESEQAAREEA 234
Cdd:TIGR00658 161 CNSLMLAGAKLGMDVVVATPEGYEPDADIVkkaqeiaKENGGSVELTHDPVEAVKGADVIYTDVWVSMGEEDKKEERLKL 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 500137526  235 FRGFCVTESLMECAGEQALFMHCLPAHRGEEVEAAVLEGPQSVVWDEAENRLHAQKALLEFLM 297
Cdd:TIGR00658 241 FRPYQVNEELMELAKPEVIFMHCLPAHRGEEVTDEVIEGPHSIVFDQAENRLHAQKAVMVALL 303
OTCace_N pfam02729
Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;
3-142 7.95e-76

Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;


Pssm-ID: 460665 [Multi-domain]  Cd Length: 140  Bit Score: 228.08  E-value: 7.95e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526    3 HFLTLRDCSVDEIHQLLRRATELRDMHRAGHLHQPLQGRVLGMVFEKSSTRTRVSFEAGMAQLGGHALFLSPRDTQLGRG 82
Cdd:pfam02729   1 HFLSLEDLSREEIEALLDLAAELKEARKRGKKLPLLKGKTVALLFEEPSTRTRVSFEVAAKRLGGHVIYLSSSDIQLSSG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526   83 EPVEDTARVVSRMVDAVMIRTFGHDMLERFAGHSAAPVINGLSDLCHPCQLLADLQTFTE 142
Cdd:pfam02729  81 ESLADTARVLSRYVDAIVIRHFGHEDLEELAEYASVPVINAGGDHEHPTQALADLLTIRE 140
 
Name Accession Description Interval E-value
PRK00779 PRK00779
ornithine carbamoyltransferase; Provisional
 1-297 0e+00

ornithine carbamoyltransferase; Provisional


Pssm-ID: 234835 [Multi-domain]  Cd Length: 304  Bit Score: 569.34  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526   1 MRHFLTLRDCSVDEIHQLLRRATELRDMHRAGHLHQPLQGRVLGMVFEKSSTRTRVSFEAGMAQLGGHALFLSPRDTQLG 80
Cdd:PRK00779   4 GRHFLSLDDLSPEELEELLDLAAELKKKRKAGEPHPPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIFLSPRDTQLG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526  81 RGEPVEDTARVVSRMVDAVMIRTFGHDMLERFAGHSAAPVINGLSDLCHPCQLLADLQTFTEHRGPITDRRVAWIGDGNN 160
Cdd:PRK00779  84 RGEPIEDTARVLSRYVDAIMIRTFEHETLEELAEYSTVPVINGLTDLSHPCQILADLLTIYEHRGSLKGLKVAWVGDGNN 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526 161 MCHSWIEAAGLLGFDLHIAAPPGYRPEADILALG----GDRVQVFDDAYAAAEGADLVTTDVWASMGQESEQAAREEAFR 236
Cdd:PRK00779 164 VANSLLLAAALLGFDLRVATPKGYEPDPEIVEKIaketGASIEVTHDPKEAVKGADVVYTDVWVSMGQEAEAEERLKAFA 243

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 500137526 237 GFCVTESLMECAGEQALFMHCLPAHRGEEVEAAVLEGPQSVVWDEAENRLHAQKALLEFLM 297
Cdd:PRK00779 244 PYQVNEELMALAKPDAIFMHCLPAHRGEEVTDEVIDGPQSVVWDEAENRLHAQKALLAWLL 304
ArgF COG0078
Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine ...
 1-299 0e+00

Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine carbamoyltransferase is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 439848 [Multi-domain]  Cd Length: 310  Bit Score: 536.94  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526   1 MRHFLTLRDCSVDEIHQLLRRATELRDMHRAGHLHQPLQGRVLGMVFEKSSTRTRVSFEAGMAQLGGHALFLSPRDTQLG 80
Cdd:COG0078    5 GRHFLSLLDLTPEELRALLDLAAELKAKRKAGIPHRPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIYLDPGDSQLG 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526  81 RGEPVEDTARVVSRMVDAVMIRTFGHDMLERFAGHSAAPVINGLSDLCHPCQLLADLQTFTEHRGPITDRRVAWIGDGNN 160
Cdd:COG0078   85 RGESIKDTARVLSRYVDGIMIRTFGHETLEELAKYAGVPVINGLTDLFHPCQALADLLTIREHFGKLKGLKVAYVGDGNN 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526 161 MCHSWIEAAGLLGFDLHIAAPPGYRPEADILAL-------GGDRVQVFDDAYAAAEGADLVTTDVWASMGQESEQAAREE 233
Cdd:COG0078  165 VANSLLLAAAKLGMDVRIATPEGYEPDPEIVAKakeiaaeSGGSITITHDPAEAVKGADVVYTDVWVSMGQEEEAEERIK 244

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 500137526 234 AFRGFCVTESLMECAGEQALFMHCLPAHRGEEVEAAVLEGPQSVVWDEAENRLHAQKALLEFLMLG 299
Cdd:COG0078  245 AFKPYQVNEELMALAKPDAIFMHCLPAHRGEEVTDEVIDGPQSVVFDEAENRLHAQKALLAWLLGG 310
orni_carb_tr TIGR00658
ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in ...
 2-297 1.71e-148

ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in a superfamily with the related enzyme aspartate carbamoyltransferase. Most known examples are anabolic, playing a role in arginine biosynthesis, but some are catabolic. Most OTCases are homotrimers, but the homotrimers are organized into dodecamers built from four trimers in at least two species; the catabolic OTCase of Pseudomonas aeruginosa is allosterically regulated, while OTCase of the extreme thermophile Pyrococcus furiosus shows both allostery and thermophily. [Amino acid biosynthesis, Glutamate family]


Pssm-ID: 129743 [Multi-domain]  Cd Length: 304  Bit Score: 418.68  E-value: 1.71e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526    2 RHFLTLRDCSVDEIHQLLRRATELRDMHRAGHLHQPLQGRVLGMVFEKSSTRTRVSFEAGMAQLGGHALFLSPRDTQLGR 81
Cdd:TIGR00658   1 RHLLSLLDLSPEEIRYLLQLAKKLKKGKKKGKEHKKLKGKTLALIFEKPSTRTRVSFEVAAYQLGGHPLYLNPNDLQLGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526   82 GEPVEDTARVVSRMVDAVMIRTFGHDMLERFAGHSAAPVINGLSDLCHPCQLLADLQTFTEHRGPITDRRVAWIGDGNNM 161
Cdd:TIGR00658  81 GESIKDTARVLSRYVDGIMARVYKHEDVEELAKYASVPVINGLTDLFHPCQALADLLTIIEHFGKLKGVKVVYVGDGNNV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526  162 CHSWIEAAGLLGFDLHIAAPPGYRPEADIL-------ALGGDRVQVFDDAYAAAEGADLVTTDVWASMGQESEQAAREEA 234
Cdd:TIGR00658 161 CNSLMLAGAKLGMDVVVATPEGYEPDADIVkkaqeiaKENGGSVELTHDPVEAVKGADVIYTDVWVSMGEEDKKEERLKL 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 500137526  235 FRGFCVTESLMECAGEQALFMHCLPAHRGEEVEAAVLEGPQSVVWDEAENRLHAQKALLEFLM 297
Cdd:TIGR00658 241 FRPYQVNEELMELAKPEVIFMHCLPAHRGEEVTDEVIEGPHSIVFDQAENRLHAQKAVMVALL 303
PLN02342 PLN02342
ornithine carbamoyltransferase
 1-293 6.82e-125

ornithine carbamoyltransferase


Pssm-ID: 177976 [Multi-domain]  Cd Length: 348  Bit Score: 360.26  E-value: 6.82e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526   1 MRHFLTLRDCSVDEIHQLLRRATELRDMHRAGHL-HQPLQGRVLGMVFEKSSTRTRVSFEAGMAQLGGHALFLSPRDTQL 79
Cdd:PLN02342  45 PKHFLHIDDFDKEEILGLLDRAKEVKALLKSGDRsFQPFKGKSMAMIFTKPSMRTRVSFETGFFLLGGHALYLGPDDIQL 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526  80 GRGEPVEDTARVVSRMVDAVMIRTFGHDMLERFAGHSAAPVINGLSDLCHPCQLLADLQTFTEHRGPITDRRVAWIGDGN 159
Cdd:PLN02342 125 GKREETRDIARVLSRYNDIIMARVFAHQDVLDLAEYSSVPVINGLTDYNHPCQIMADALTIIEHIGRLEGTKVVYVGDGN 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526 160 NMCHSWIEAAGLLGFDLHIAAPPGYRPEADIL----ALGGDRVQVFDDAYAAAEGADLVTTDVWASMGQESEQAAREEAF 235
Cdd:PLN02342 205 NIVHSWLLLAAVLPFHFVCACPKGYEPDAKTVekarAAGISKIEITNDPAEAVKGADVVYTDVWASMGQKEEAEKRKKAF 284

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 500137526 236 RGFCVTESLMECAGEQALFMHCLPAHRGEEVEAAVLEGPQSVVWDEAENRLHAQKALL 293
Cdd:PLN02342 285 QGFQVNEALMKLAGPQAYFMHCLPAERGVEVTDGVMEAPNSIVFPQAENRMHAQNAIM 342
PRK02102 PRK02102
ornithine carbamoyltransferase; Validated
 2-293 1.83e-115

ornithine carbamoyltransferase; Validated


Pssm-ID: 179366 [Multi-domain]  Cd Length: 331  Bit Score: 335.70  E-value: 1.83e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526   2 RHFLTLRDCSVDEIHQLLRRATELRDMHRAGHLHQPLQGRVLGMVFEKSSTRTRVSFEAGMAQLGGHALFLSPRDTQLGR 81
Cdd:PRK02102   8 RSFLKLLDFTPEEIEYLIDLSIELKAAKKAGIEHQYLEGKNIALIFEKTSTRTRCAFEVAAIDLGAHVTYLGPNDSQLGK 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526  82 GEPVEDTARVVSRMVDAVMIRTFGHDMLERFAGHSAAPVINGLSDLCHPCQLLADLQTFTEHRGPITDRRVAWIGDG-NN 160
Cdd:PRK02102  88 KESIEDTARVLGRMYDGIEYRGFKQEIVEELAKYSGVPVWNGLTDEWHPTQMLADFMTMKEHFGPLKGLKLAYVGDGrNN 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526 161 MCHSWIEAAGLLGFDLHIAAPPGYRPEADILAL-------GGDRVQVFDDAYAAAEGADLVTTDVWASMGQESEQAAREE 233
Cdd:PRK02102 168 MANSLMVGGAKLGMDVRICAPKELWPEEELVALareiakeTGAKITITEDPEEAVKGADVIYTDVWVSMGEEDEWEERIK 247

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 500137526 234 AFRGFCVTESLMECAG-EQALFMHCLPA-----------------HRGEEVEAAVLEGPQSVVWDEAENRLHAQKALL 293
Cdd:PRK02102 248 LLKPYQVNMDLMKATGnPDVIFMHCLPAfhdtetkvgkeiaekygLKGLEVTDEVFESKYSIVFDEAENRMHTIKAVM 325
putr_carbamoyl TIGR04384
putrescine carbamoyltransferase; Members of this family are putrescine carbamoyltransferase ...
 3-297 3.22e-106

putrescine carbamoyltransferase; Members of this family are putrescine carbamoyltransferase (EC 2.1.3.6). There is some overlapping specificity with ornithine carbamoyltransferase (EC 2.1.3.3). The gene regularly is found next to agmatine deiminase and a carbamate kinase, suggesting a conserved catabolic agmatine deiminase pathway. [Energy metabolism, Amino acids and amines]


Pssm-ID: 275177  Cd Length: 330  Bit Score: 312.35  E-value: 3.22e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526    3 HFLTLRDCSVDEIHQLLRRATELRDMHRAGHLHQPLQGRVLGMVFEKSSTRTRVSFEAGMAQLGGHALFLSPRDTQLGRG 82
Cdd:TIGR04384   1 DFIDTNDFTKEEILDIIDLSLKIKEAIKDGYYPPLLKNKSLGMIFEQSSTRTRVSFETAMTQLGGHAQYLAPGQIQLGGH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526   83 EPVEDTARVVSRMVDAVMIRTFGHDMLERFAGHSAAPVINGLSDLCHPCQLLADLQTFTEHR---GPITDRRVAWIGDGN 159
Cdd:TIGR04384  81 ESIEDTARVLSRLVDIIMARVDRHETVVELAKYATVPVINGMSDYNHPTQELGDLFTMIEHLpagKKLEDCKVVFVGDAT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526  160 NMCHSWIEAAGLLGFDLHIAAPPGYRPEADILALG-------GDRVQVFDDAYAAAEGADLVTTDVWASM-GQESEQAAR 231
Cdd:TIGR04384 161 QVCVSLMFICTKMGMDFVHFGPKGYQIPEEWLAIAeanckvsGGSVTVTDDVDEAVKGADFIYTDVWYGLyDQELSEEER 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 500137526  232 EEAFR-GFCVTESLMECAGEQALFMHCLPAHRGEEVEAAVLEGPQSVVWDEAENRLHAQKALLEFLM 297
Cdd:TIGR04384 241 MAIFYpKYQVNPELMAKAGPHAKFMHCLPASRGEEVTDEVMDSPQSICFDEAENRLTAIRALLVYFL 307
PRK14805 PRK14805
ornithine carbamoyltransferase; Provisional
 1-293 2.97e-92

ornithine carbamoyltransferase; Provisional


Pssm-ID: 237819 [Multi-domain]  Cd Length: 302  Bit Score: 275.80  E-value: 2.97e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526   1 MRHFLTLRDCSVDEIHQLLRRATELRDmHRAGHlHQPLQGRVLGMVFEKSSTRTRVSFEAGMAQLGGHALFLSPRDTQLG 80
Cdd:PRK14805   1 MKHLLSIKELTQQQLLDLLALAKTIKA-NPAEY-RQALAGKSVVMLFEKPSLRTRVSFDIGINKLGGHCLYLDQQNGALG 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526  81 RGEPVEDTARVVSRMVDAVMIRTFGHDMLERFAGHSAAPVINGLSDLCHPCQLLADLQTFTEHRGPITDRRVAWIGDGNN 160
Cdd:PRK14805  79 KRESVADFAANLSCWADAIVARVFSHSTIEQLAEHGSVPVINALCDLYHPCQALADFLTLAEQFGDVSKVKLAYVGDGNN 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526 161 MCHSWIEAAGLLGFDLHIAAPPGYRPEADILALG-------GDRVQVFDDAyAAAEGADLVTTDVWASMGQESEQAAREE 233
Cdd:PRK14805 159 VTHSLMYGAAILGATMTVICPPGHFPDGQIVAEAqelaaksGGKLVLTSDI-EAIEGHDAIYTDTWISMGDDTPLAEIKA 237

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526 234 AFRGFCVTESLMECAGEQaLFMHCLPAHRGEEVEAAVLEGPQSVVWDEAENRLHAQKALL 293
Cdd:PRK14805 238 KFAPYQVNKALMEKAGAT-FVMHCQPAHRGVEITSEVMDGEGSLILQQAENRMHAQNAVL 296
PRK04284 PRK04284
ornithine carbamoyltransferase; Provisional
 2-293 1.96e-80

ornithine carbamoyltransferase; Provisional


Pssm-ID: 235269 [Multi-domain]  Cd Length: 332  Bit Score: 246.58  E-value: 1.96e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526   2 RHFLTLRDCSVDEIHQLLRRATELRDMHRAGHLHQPLQGRVLGMVFEKSSTRTRVSFEAGMAQLGGHALFLSPRDTQLGR 81
Cdd:PRK04284   7 RSFLTLLDFTPKEIEYLLDLSEDLKRAKYAGIEVQKLKGKNIALIFEKDSTRTRCAFEVAAYDQGAHVTYLGPTGSQMGK 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526  82 GEPVEDTARVVSRMVDAVMIRTFGHDMLERFAGHSAAPVINGLSDLCHPCQLLADLQTFTEH-RGPITDRRVAWIGDG-N 159
Cdd:PRK04284  87 KESTKDTARVLGGMYDGIEYRGFSQRTVETLAEYSGVPVWNGLTDEDHPTQVLADFLTAKEHlKKPYKDIKFTYVGDGrN 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526 160 NMCHSWIEAAGLLGFDLHIAAPPGYRPEADIL-------ALGGDRVQVFDDAYAAAEGADLVTTDVWASMGQESEQ-AAR 231
Cdd:PRK04284 167 NVANALMQGAAIMGMDFHLVCPKELNPDDELLnkckeiaAETGGKITITDDIDEGVKGSDVIYTDVWVSMGEPDEVwEER 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526 232 EEAFRGFCVTESLMECAGE-QALFMHCLPA-H----------------RGEEVEAAVLEGPQSVVWDEAENRLHAQKALL 293
Cdd:PRK04284 247 IKLLKPYQVNKEMMKKTGNpNAIFEHCLPSfHdldtkvgkeifekyglKEMEVTDEVFESKASVVFDEAENRMHTIKAVM 326
PRK03515 PRK03515
ornithine carbamoyltransferase subunit I; Provisional
 2-293 4.61e-80

ornithine carbamoyltransferase subunit I; Provisional


Pssm-ID: 179587 [Multi-domain]  Cd Length: 336  Bit Score: 245.78  E-value: 4.61e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526   2 RHFLTLRDCSVDEIHQLLRRATELRDMHRAGHLHQPLQGRVLGMVFEKSSTRTRVSFEAGMAQLGGHALFLSPRDTQLGR 81
Cdd:PRK03515   7 RHFLRLLDFTPAELNSLLQLAAKLKADKKNGKEEQKLTGKNIALIFEKDSTRTRCSFEVAAYDQGARVTYLGPSGSQIGH 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526  82 GEPVEDTARVVSRMVDAVMIRTFGHDMLERFAGHSAAPVINGLSDLCHPCQLLADLQTFTEH--RGPITDRRVAWIGDG- 158
Cdd:PRK03515  87 KESIKDTARVLGRMYDGIQYRGYGQEIVETLAEYAGVPVWNGLTNEFHPTQLLADLLTMQEHlpGKAFNEMTLAYAGDAr 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526 159 NNMCHSWIEAAGLLGFDLHIAAPPGYRPEADILA-------LGGDRVQVFDDAYAAAEGADLVTTDVWASMGQESEQ-AA 230
Cdd:PRK03515 167 NNMGNSLLEAAALTGLDLRLVAPKACWPEAALVTecralaqKNGGNITLTEDIAEGVKGADFIYTDVWVSMGEPKEVwAE 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526 231 REEAFRGFCVTESLMECAGE-QALFMHCLPA------------------HRGEEVEAAVLEGPQSVVWDEAENRLHAQKA 291
Cdd:PRK03515 247 RIALLRPYQVNSKMMQLTGNpQVKFLHCLPAfhddqttlgkkmaeeyglHGGMEVTDEVFESAHSIVFDQAENRLHTIKA 326


                 ..
gi 500137526 292 LL 293
Cdd:PRK03515 327 VM 328
OTCace_N pfam02729
Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;
3-142 7.95e-76

Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;


Pssm-ID: 460665 [Multi-domain]  Cd Length: 140  Bit Score: 228.08  E-value: 7.95e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526    3 HFLTLRDCSVDEIHQLLRRATELRDMHRAGHLHQPLQGRVLGMVFEKSSTRTRVSFEAGMAQLGGHALFLSPRDTQLGRG 82
Cdd:pfam02729   1 HFLSLEDLSREEIEALLDLAAELKEARKRGKKLPLLKGKTVALLFEEPSTRTRVSFEVAAKRLGGHVIYLSSSDIQLSSG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526   83 EPVEDTARVVSRMVDAVMIRTFGHDMLERFAGHSAAPVINGLSDLCHPCQLLADLQTFTE 142
Cdd:pfam02729  81 ESLADTARVLSRYVDAIVIRHFGHEDLEELAEYASVPVINAGGDHEHPTQALADLLTIRE 140
PRK12562 PRK12562
ornithine carbamoyltransferase subunit F; Provisional
 2-293 1.37e-70

ornithine carbamoyltransferase subunit F; Provisional


Pssm-ID: 105755  Cd Length: 334  Bit Score: 221.47  E-value: 1.37e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526   2 RHFLTLRDCSVDEIHQLLRRATELRDMHRAGHLHQPLQGRVLGMVFEKSSTRTRVSFEAGMAQLGGHALFLSPRDTQLGR 81
Cdd:PRK12562   7 KHFLKLLDFTPAELNSLLQLAAKLKADKKNGKEVARLTGKNIALIFEKDSTRTRCSFEVAAYDQGARVTYLGPSGSQIGH 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526  82 GEPVEDTARVVSRMVDAVMIRTFGHDMLERFAGHSAAPVINGLSDLCHPCQLLADLQTFTEHR--GPITDRRVAWIGDG- 158
Cdd:PRK12562  87 KESIKDTARVLGRMYDGIQYRGHGQEVVETLAEYAGVPVWNGLTNEFHPTQLLADLLTMQEHLpgKAFNEMTLVYAGDAr 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526 159 NNMCHSWIEAAGLLGFDLHIAAPPGYRPEADILA-------LGGDRVQVFDDAYAAAEGADLVTTDVWASMGQESEQ-AA 230
Cdd:PRK12562 167 NNMGNSMLEAAALTGLDLRLVAPQACWPEASLVAecsalaqKHGGKITLTEDIAAGVKGADFIYTDVWVSMGEPKEKwAE 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526 231 REEAFRGFCVTESLMECAGE-QALFMHCLPA------------------HRGEEVEAAVLEGPQSVVWDEAENRLHAQKA 291
Cdd:PRK12562 247 RIALLRGYQVNSKMMALTGNpQVKFLHCLPAfhddqttlgkkmakefglHGGMEVTDEVFESPASIVFDQAENRMHTIKA 326


                 ..
gi 500137526 292 LL 293
Cdd:PRK12562 327 VM 328
PRK01713 PRK01713
ornithine carbamoyltransferase; Provisional
 2-293 3.89e-68

ornithine carbamoyltransferase; Provisional


Pssm-ID: 167263 [Multi-domain]  Cd Length: 334  Bit Score: 215.23  E-value: 3.89e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526   2 RHFLTLRDCSVDEIHQLLRRATELRDMHRAGHLHQPLQGRVLGMVFEKSSTRTRVSFEAGMAQLGGHALFLSPRDTQLGR 81
Cdd:PRK01713   8 RHLLSLVNHTEREIKYLLDLSRDLKRAKYAGTEQQRLKGKNIALIFEKTSTRTRCAFEVAAYDQGAQVTYIDPNSSQIGH 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526  82 GEPVEDTARVVSRMVDAVMIRTFGHDMLERFAGHSAAPVINGLSDLCHPCQLLADLQTFTEH-RGPITDRRVAWIGDG-N 159
Cdd:PRK01713  88 KESMKDTARVLGRMYDAIEYRGFKQSIVNELAEYAGVPVFNGLTDEFHPTQMLADVLTMIENcDKPLSEISYVYIGDArN 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526 160 NMCHSWIEAAGLLGFDLHIAAPPGYRPEADILAL-------GGDRVQVFDDAYAAAEGADLVTTDVWASMGQESEQ-AAR 231
Cdd:PRK01713 168 NMGNSLLLIGAKLGMDVRICAPKALLPEASLVEMcekfakeSGARITVTDDIDKAVKGVDFVHTDVWVSMGEPLETwGER 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526 232 EEAFRGFCVTESLMECAGEQAL-FMHCLPA-HRGE------------------EVEAAVLEGPQSVVWDEAENRLHAQKA 291
Cdd:PRK01713 248 IKLLMPYQVTPELMKRTGNPKVkFMHCLPAfHNSEtkvgrqiaekypelangiEVTEDVFESPMNIAFEQAENRMHTIKA 327


                 ..
gi 500137526 292 LL 293
Cdd:PRK01713 328 VM 329
OTCace pfam00185
Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain;
151-296 1.39e-65

Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain;


Pssm-ID: 425511 [Multi-domain]  Cd Length: 154  Bit Score: 202.45  E-value: 1.39e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526  151 RVAWIGDG-NNMCHSWIEAAGLLGFDLHIAAPPGYRPEADIL-------ALGGDRVQVFDDAYAAAEGADLVTTDVWASM 222
Cdd:pfam00185   1 KIAYVGDGhNNVAHSLIIAAAKLGMDVRLATPKGYPPDPEVLdkakkiaEKSGGSIEITDDPAEAVKGADVVYTDVWQSM 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 500137526  223 GQESEQAAREEAFRGFCVTESLMECAGEQALFMHCLPAHRGEEVEAAVLEGPQSVVWDEAENRLHAQKALLEFL 296
Cdd:pfam00185  81 GQEKEREERLKAFKPYQVNEELMKLAKKDAIFMHCLPAHRGEEVTDDVFDGPRSVVFDQAENRLHAQKALLALL 154
PRK04523 PRK04523
N-acetylornithine carbamoyltransferase; Reviewed
 1-296 1.92e-60

N-acetylornithine carbamoyltransferase; Reviewed


Pssm-ID: 235304 [Multi-domain]  Cd Length: 335  Bit Score: 195.35  E-value: 1.92e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526   1 MRHFLTLRDCSVDEIHQLLRRAtelrDMHRAGHLHQPLQGRVLGMVFEKSSTRTRVSFEAGMAQLGGHALFLSP-RDT-- 77
Cdd:PRK04523   3 LKHFLNTQDWSRAELDALLTQA----AAFKRNKLGSALKGKSIALVFFNPSLRTRTSFELGAFQLGGHAVVLQPgKDAwp 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526  78 ---QLG------RGEPVEDTARVVSRMVDAVMIRTF------GHD----MLERFAGHSAAPVINgLSDLCHPCQLLADLQ 138
Cdd:PRK04523  79 iefELGavmdgeTEEHIREVARVLSRYVDLIGVRAFpkfvdwSKDrqdqVLNSFAKYSTVPVIN-METITHPCQELAHAL 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526 139 TFTEHRGPITDRR---VAWIGDGN--NMC--HSWIEAAGLLGFDLHIAAP-------PGYRPEADILAL-GGDRVQVFDD 203
Cdd:PRK04523 158 ALQEHFGTTLRGKkyvLTWTYHPKplNTAvaNSALLIATRLGMDVTLLCPtpdyildERYMDWAEQNAAeSGGSLTVSHD 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526 204 AYAAAEGADLVTTDVWASM----GQESEQAAREeAFRGFCVTESLMECAgEQALFMHCLPAHRGEEVEAAVLEGPQSVVW 279
Cdd:PRK04523 238 IDSAYAGADVVYAKSWGALpffgNWEPEKPIRD-QYQHFIVDERKMALT-NNGVFSHCLPLRRNVKVTDAVMDSPNCIAI 315

                        330
                 ....*....|....*..
gi 500137526 280 DEAENRLHAQKALLEFL 296
Cdd:PRK04523 316 DEAENRLHVQKAIMAAL 332
PyrB COG0540
Aspartate carbamoyltransferase, catalytic subunit [Nucleotide transport and metabolism]; ...
 1-299 3.27e-51

Aspartate carbamoyltransferase, catalytic subunit [Nucleotide transport and metabolism]; Aspartate carbamoyltransferase, catalytic subunit is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440306 [Multi-domain]  Cd Length: 306  Bit Score: 170.62  E-value: 3.27e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526   1 MRHFLTLRDCSVDEIHQLLRRATELRDMHRAGHLHQPLQGRVLGMVFEKSSTRTRVSFEAGMAQLGGHALFLSPRDTQLG 80
Cdd:COG0540    5 MRHLLSIEDLSREEIEELLDTAEEFKEVLRPIKKVPLLRGKTVANLFFEPSTRTRLSFELAAKRLGADVINFSASTSSVS 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526  81 RGEPVEDTARVVSRM-VDAVMIRTFGHDMLERFAGHSAAPVINGlSDLC--HPCQLLADLQTFTEHRGPITDRRVAWIGD 157
Cdd:COG0540   85 KGESLADTIRTLEAYgADAIVIRHPQEGAARLLAEHVDVPVINA-GDGAheHPTQALLDLYTIREEFGRLDGLKVAIVGD 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526 158 GNNM--CHSWIEAAGLLGFDLHIAAPPGYRPEaDILALGgdrVQVFDDAYAAAEGADLV-TTDVWASMGQESEQAAREEA 234
Cdd:COG0540  164 LKHSrvARSNIKALSKLGAEVTLVAPPTLLPE-EIEELG---VEVTTDLDEALPDADVVyMLRIQKERFTDGLFPSYREY 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 500137526 235 FRGFCVTESLMECAGEQALFMHCLPAHRGEEVEAAVLEGPQSVVWDEAENRLHAQKALLEFLMLG 299
Cdd:COG0540  240 KRSYGLTAERLALAKPDAIVMHPGPRNRGVEIDSDVDDTPRSVIFEQVTNGVAVRMALLYLLLGG 304
PRK14804 PRK14804
ornithine carbamoyltransferase; Provisional
 1-293 1.21e-50

ornithine carbamoyltransferase; Provisional


Pssm-ID: 173265 [Multi-domain]  Cd Length: 311  Bit Score: 169.44  E-value: 1.21e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526   1 MRHFLTLRDCSVDEIHQLLRRATELRD--MHRAGHLhqplQGRVLGMVFEKSSTRTRVSFEAGMAQLGGHALFLS--PRD 76
Cdd:PRK14804   6 VKHLISWEDWSDSEILDLLDFAVHVKKnrVNYAGHM----SGRSLAMLFQKTSTRTRVSFEVAMTEMGGHGIYLDwmASN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526  77 TQLgrgEPVEDTARVVSRMVDAVMIRTFGHDMLERFAGHSAAPVINGLSDLCHPCQLLADLQTFT--EHRGPITDRRVAW 154
Cdd:PRK14804  82 FQL---SDIDLEARYLSRNVSVIMARLKKHEDLLVMKNGSQVPVINGCDNMFHPCQSLADIMTIAldSPEIPLNQKQLTY 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526 155 IGDGNNMCHSWIEAAGLLGFDLHIAAPPGYR----PEADILALGGDRVQVFDDAYAAAEGADLVTTDVWASM------GQ 224
Cdd:PRK14804 159 IGVHNNVVNSLIGITAALGIHLTLVTPIAAKenihAQTVERAKKKGTLSWEMNLHKAVSHADYVYTDTWLDMeffndpSY 238

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 500137526 225 ESEQAAREEAFRGFCVTESLMEcaGEQALFMHCLPAHRGEEVEAAVLEGPQSVVWDEAENRLHAQKALL 293
Cdd:PRK14804 239 ADKKKQRMELMMPYQINSSLME--KTNAKVMHDMPIHAGYEITREVVLSDRSIIFQQAENRLDAQKAVI 305
pyrB PRK00856
aspartate carbamoyltransferase catalytic subunit;
1-299 3.09e-44

aspartate carbamoyltransferase catalytic subunit;


Pssm-ID: 234849 [Multi-domain]  Cd Length: 305  Bit Score: 152.53  E-value: 3.09e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526   1 MRHFLTLRDCSVDEIHQLLRRATELRDMHRAGHLHQP-LQGRVLGMVFEKSSTRTRVSFEAGMAQLGGHALFLSPRDTQL 79
Cdd:PRK00856   5 MKHLLSIEDLSREEIELLLDTAEEFKEVLRREVKKVPlLRGKTVANLFFEPSTRTRLSFELAAKRLGADVINFSASTSSV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526  80 GRGEPVEDTARVVSRM-VDAVMIRtfgHDM---LERFAGHSAAPVINGlSDLC--HPCQLLADLQTFTEHRGPITDRRVA 153
Cdd:PRK00856  85 SKGETLADTIRTLSAMgADAIVIR---HPQsgaARLLAESSDVPVINA-GDGShqHPTQALLDLLTIREEFGRLEGLKVA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526 154 WIGDGNN--MCHSWIEAAGLLGFDLHIAAPPGYRPEadilalGGDRVQVFDDAYAAAEGADLV-TTDVwasmgqeseQAA 230
Cdd:PRK00856 161 IVGDIKHsrVARSNIQALTRLGAEVRLIAPPTLLPE------GMPEYGVHTDLDEVIEDADVVmMLRV---------QKE 225

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 500137526 231 R---------EEAFRGFCVTESLMECAGEQALFMHCLPAHRGEEVEAAVLEGPQSVVWDEAENRLHAQKALLEFLMLG 299
Cdd:PRK00856 226 RmdggllpsyEEYKRSYGLTAERLALAKPDAIVMHPGPVNRGVEIASDVADGPQSVIFEQVTNGVAVRMAVLELLLGG 303
asp_carb_tr TIGR00670
aspartate carbamoyltransferase; Aspartate transcarbamylase (ATCase) is an alternate name.PyrB ...
 2-298 4.75e-43

aspartate carbamoyltransferase; Aspartate transcarbamylase (ATCase) is an alternate name.PyrB encodes the catalytic chain of aspartate carbamoyltransferase, an enzyme of pyrimidine biosynthesis, which organizes into trimers. In some species, including E. coli and the Archaea but excluding Bacillus subtilis, a regulatory subunit PyrI is also present in an allosterically regulated hexameric holoenzyme. Several molecular weight classes of ATCase are described in MEDLINE:96303527 and often vary within taxa. PyrB and PyrI are fused in Thermotoga maritima.Ornithine carbamoyltransferases are in the same superfamily and form an outgroup. [Purines, pyrimidines, nucleosides, and nucleotides, Pyrimidine ribonucleotide biosynthesis]


Pssm-ID: 273209 [Multi-domain]  Cd Length: 301  Bit Score: 149.43  E-value: 4.75e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526    2 RHFLTLRDCSVDEIHQLLRRATELRDMHRAGHLHQPLQGRVLGMVFEKSSTRTRVSFEAGMAQLGGHALFLSPRDT-QLG 80
Cdd:TIGR00670   1 RHLISISDLSREEIELLLETARELEQVLNGKEPLKLLKGKILANLFFEPSTRTRLSFETAMKRLGGSVVNFSDSETsSVA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526   81 RGEPVEDTARVVSRMVDAVMIRTfGHDMLERFAGH-SAAPVINGlSDLC--HPCQLLADLQTFTEHRGPITDRRVAWIGD 157
Cdd:TIGR00670  81 KGETLADTIKTLSGYVDAIVIRH-PLEGAARLAAEvSEVPVINA-GDGSnqHPTQTLLDLYTIYEEFGRLDGLKIALVGD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526  158 GNN--MCHSWIEAAGLLGFDLHIAAPPGYRPEADI---LALGGDRVQVFDDAYAAAEGAD-LVTTDVWAS-MGQESEQAA 230
Cdd:TIGR00670 159 LKYgrTVHSLAEALTRFGVEVYLISPEELRMPKEIleeLKAKGIKVRETESLEEVIDEADvLYVTRIQKErFPDPEEYEK 238

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 500137526  231 REEAfrgFCVTESLMECAGEQALFMHCLPahRGEEVEAAVLEGPQSVVWDEAENRLHAQKALLEFLML 298
Cdd:TIGR00670 239 VKGS---YGITLERLEAAKKGVIIMHPLP--RVDEIDPSVDDTPHAKYFKQAFNGVPVRMALLALLLG 301
PLN02527 PLN02527
aspartate carbamoyltransferase
 18-300 5.13e-24

aspartate carbamoyltransferase


Pssm-ID: 178142 [Multi-domain]  Cd Length: 306  Bit Score: 99.05  E-value: 5.13e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526  18 LLRRATELRDMHRAGHLHQPLQGRVLGMVFEKSSTRTRVSFEAGMAQLGGHALFL-SPRDTQ-LGRGEPVEDTARVVSRM 95
Cdd:PLN02527  17 LFEVAREMEKVERGSPGSQMLKGYLMATLFYEPSTRTRLSFESAMKRLGGEVLTTeNAGEFSsAAKGETLEDTIRTVEGY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526  96 VDAVMIRTFGHDMLERFAGHSAAPVIN-GLSDLCHPCQLLADLQTFTEHRGPITDRRVAWIGDGNN--MCHSwieAAGLL 172
Cdd:PLN02527  97 SDIIVLRHFESGAARRAAATAEIPVINaGDGPGQHPTQALLDVYTIQREIGRLDGIKVGLVGDLANgrTVRS---LAYLL 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526 173 ----GFDLHIAAPPGYRPEADI---LALGGDRVQVFDDAYAAAEGAD-LVTTDVWASMGQESEQAAreEAFRG-FCVTES 243
Cdd:PLN02527 174 akyeDVKIYFVAPDVVKMKDDIkdyLTSKGVEWEESSDLMEVASKCDvLYQTRIQRERFGERIDLY--EAARGkYIVDKK 251

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 500137526 244 LMECAGEQALFMHCLPahRGEEVEAAVLEGPQSVVWDEAENRLHAQKALLEFLMLGY 300
Cdd:PLN02527 252 VMDVLPKHAVVMHPLP--RLDEITTDVDSDPRAAYFRQAKNGLFIRMALLKLLLGGW 306
PRK11891 PRK11891
aspartate carbamoyltransferase; Provisional
 3-259 7.08e-22

aspartate carbamoyltransferase; Provisional


Pssm-ID: 183362 [Multi-domain]  Cd Length: 429  Bit Score: 94.93  E-value: 7.08e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526   3 HFLTLRDCSVDEIHQLLRRATELRDMHRAGHLHQPLQGRVLGMVFEKSSTRTRVSFEAGMAQLGGhalflSPRDT----- 77
Cdd:PRK11891  89 QLLSVDQFSRDSVEALFRVADVMQPIARRQKISRVLEGAVLGNLFFEASTRTRVSFGAAFCRLGG-----SVCDTtgftf 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526  78 -QLGRGEPVEDTARVVSRMVDAVMIRTFGHDMLERFAGHSAAPVINGLSDLC-HPCQLLADLQTF-TE--HRGPITD-RR 151
Cdd:PRK11891 164 sSMAKGESIYDTSRVMSGYVDALVIRHPEQGSVAEFARATNLPVINGGDGPGeHPSQALLDLYTIqREfsRLGKIVDgAH 243

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526 152 VAWIGD---GNNMcHSWIEAAGLL-GFDLHIAAPPGYRPEADI---LALGGDRVQVFDDAYAAAEGADLvttdVWASMGQ 224
Cdd:PRK11891 244 IALVGDlkyGRTV-HSLVKLLALYrGLKFTLVSPPTLEMPAYIveqISRNGHVIEQTDDLAAGLRGADV----VYATRIQ 318

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 500137526 225 EsEQAAREE---AFRGFCVTESLMECA-GEQALFMHCLP 259
Cdd:PRK11891 319 K-ERFADESfegYTPDFQINQALVDAVcKPDTLIMHPLP 356
pyrB PRK13814
aspartate carbamoyltransferase;
3-298 7.23e-22

aspartate carbamoyltransferase;


Pssm-ID: 139876 [Multi-domain]  Cd Length: 310  Bit Score: 93.24  E-value: 7.23e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526   3 HFLTLRDCSVDEIHQLLRRATE-LRDMHRAGHLHQPLQGRVLGMVFEKSSTRTRVSFEAGMAQLGGHALFLSPRDTQLGR 81
Cdd:PRK13814   7 HLLNMRSLTRDHIEKLIQRANYfLTQGMEKNSVFETLKGHVVANLFFEPSTRTRNSFEIAAKRLGAMVLNPNLKISAISK 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526  82 GEPVEDTARVVSRM-VDAVMIRTFGHDMLERFAGH-SAAPVIN-GLSDLCHPCQLLADLQTFTEHRGPITDRRVAWIGD- 157
Cdd:PRK13814  87 GETLFDTIKTLEAMgVYFFIVRHSENETPEQIAKQlSSGVVINaGDGNHQHPSQALIDLMTIKQHKPHWNKLCVTIIGDi 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526 158 -GNNMCHSWIEAAGLLGF-DLHIAAPPGYRPEadilALGGDRVQVFDDAYAAAEGADLVTTdvWASMGQESEQAAREEAF 235
Cdd:PRK13814 167 rHSRVANSLMDGLVTMGVpEIRLVGPSSLLPD----KVGNDSIKKFTELKPSLLNSDVIVT--LRLQKERHDNSVDIDAF 240

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 500137526 236 RG-FCVTESLMECAGEQALFMHCLPAHRGEEVEAAVLEGPQSVVWDEAENRLHAQKALLEFLML 298
Cdd:PRK13814 241 RGsFRLTPEKLYSAKPDAIVMHPGPVNREVEINSDVADNQQSVILQQVRNGVAMRMAVLELFLL 304
PRK07200 PRK07200
aspartate/ornithine carbamoyltransferase family protein; Validated
 4-272 2.70e-19

aspartate/ornithine carbamoyltransferase family protein; Validated


Pssm-ID: 235961 [Multi-domain]  Cd Length: 395  Bit Score: 87.10  E-value: 2.70e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526   4 FLTLrDCSVDEIHQLLRRATELRDMhRAGHLHQPLQGRVLGM-VFEKSSTRTRVSFEAGMAQLGGHALFLSPRDTQLGRG 82
Cdd:PRK07200  24 LLTW-EKTPDELKAVLDVADALRAL-REENISTKVFNSGLGIsVFRDNSTRTRFSYASACNLLGLEVQDLDEGKSQIAHG 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526  83 EPVEDTARVVSRMVDAVMIRT-----FGHDMLERFA-----GHSAA------PVINGLSDLCHPCQLLADLQTFTEHRGP 146
Cdd:PRK07200 102 ETVRETANMISFMADVIGIRDdmyigKGNAYMREVGaavddGYKQGvlpqrpTLVNLQCDIDHPTQSMADLLHLIEHFGG 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526 147 ITDRRvawigdGNNMCHSWI-------------EAAGLL---GFDLHIAAPPGYR--PEADILA------LGGDRVQVFD 202
Cdd:PRK07200 182 LENLK------GKKIAMTWAyspsygkplsvpqGIIGLMtrfGMDVTLAHPEGYDlmPEVVEVAkknakaSGGSFRQVNS 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526 203 DAyAAAEGADLVTTDVWA---SMGQ----------------ESEQAAREEAFRGFCVTESLME-CAGEQALFMHCLPA-- 260
Cdd:PRK07200 256 ME-EAFKDADIVYPKSWApykVMEErtelyragdhegikalEKELLAQNAQHKDWHCTEEMMKlTKDGKALYMHCLPAdi 334

                        330
                 ....*....|....*..
gi 500137526 261 -----HRGeEVEAAVLE 272
Cdd:PRK07200 335 sgvscKEG-EVTESVFD 350
PRK08192 PRK08192
aspartate carbamoyltransferase; Provisional
 38-157 6.38e-15

aspartate carbamoyltransferase; Provisional


Pssm-ID: 169269 [Multi-domain]  Cd Length: 338  Bit Score: 73.99  E-value: 6.38e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500137526  38 LQGRVLGMVFEKSSTRTRVSFEAGMAQLGGHAlflspRDT------QLGRGEPVEDTARVVSRMVDAVMIRTFGHDMLER 111
Cdd:PRK08192  42 LEGAILGNLFFEPSTRTRVSFGCAFNLLGGHV-----RETtgmassSLSKGESLYDTARVLSTYSDVIAMRHPDAGSVKE 116

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 500137526 112 FAGHSAAPVINGlSDLC--HPCQLLADLQT----FTEHRGPITDRRVAWIGD 157
Cdd:PRK08192 117 FAEGSRVPVING-GDGSneHPTQALLDLFTiqkeLAHAGRGIDGMHIAMVGD 167
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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