NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|500131844|ref|WP_011807849|]
View 

IlvD/Edd family dehydratase [Verminephrobacter eiseniae]

Protein Classification

IlvD/Edd family dehydratase( domain architecture ID 10012677)

IlvD/Edd family dehydratase similar to Azospirillum brasilense L-arabonate dehydratase, which catalyzes the the dehydration of L-arabonate to L-2-keto-3-deoxyarabonate

EC:  4.2.1.-
Gene Ontology:  GO:0016836|GO:0051536
PubMed:  35263023

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
PRK06131 PRK06131
dihydroxy-acid dehydratase; Validated
18-582 0e+00

dihydroxy-acid dehydratase; Validated


:

Pssm-ID: 235708  Cd Length: 571  Bit Score: 978.13  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844  18 AHGIAKGLPDYGDRGFSLFLRRAFIKGAGYTDAAL-GRPIIGIANTASAYNPCHGNAPQLIEAVKRGVLLAGGLPMDFPT 96
Cdd:PRK06131   1 TPGLLRSLAWFGDDDFRAFYHRSFMKNQGYPDELFdGRPIIGICNTWSDLNPCNAHFRQLAERVKRGVLEAGGFPVEFPV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844  97 ISVHESFSQPTSMYTRNLMSMDTEEMIRAQPMDAVVLIGGCDKTVPAQLMGAASAGIPAIALITGAMLTGAHRSQRVGAC 176
Cdd:PRK06131  81 ISLGESFLRPTAMLYRNLAAMDVEEMIRGYPIDGVVLLGGCDKTTPALLMGAASVDLPAIVLSGGPMLNGKHKGERLGSG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844 177 TDCRRYWARFRAGEIDAQEIADVNRQLVASVGTCSVMGTASTMACIAEALGMTVPGGASPPAVTADRIRVAEQTGAQAVA 256
Cdd:PRK06131 161 TDVWKYWEELRAGEIDLEEFLEAEAGMARSAGTCNTMGTASTMACMAEALGMSLPGNAAIPAVDARRIRMAELTGRRIVE 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844 257 MARSGLTIDKVLTARAFENAMRVLLAIGGSTNAIVHLTAIAGRMGYDIDLDAFDRMGRQTPVLLDLKPSGAHYMEDFHHA 336
Cdd:PRK06131 241 MVHEDLKPSDILTREAFENAIRVNAAIGGSTNAVIHLIAIAGRAGVELDLDDWDRIGRDVPVLVNLQPSGEYLMEDFYYA 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844 337 GGMATLLRELKPLLHLDALTVTGRTLGEEIERAgPGFAQQVVRPLERPIYPQGGIAVLQGNLAPGGAIIKQSTADAALME 416
Cdd:PRK06131 321 GGLPAVLRELGELLHLDALTVNGKTLGENLAGA-PVYNDDVIRPLDNPLKPEGGIAVLRGNLAPDGAVIKPSAASPELLK 399
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844 417 HEGRAVVFENAEDLARRIDSDGLDVTQADILVLKNIGPKGAPGMPEAGYIPIPRKLARAGVKDIVRISDGRMSGTAFGTI 496
Cdd:PRK06131 400 HEGRAVVFEGYEDYKARIDDPDLDVDEDTVLVLRNAGPKGYPGMPEVGNMPIPKKLLRQGVKDMVRISDARMSGTAYGTV 479
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844 497 VLHVTPEAAVGGPLAHVRNGDRIRLSVRERALTLLVDDQELARRASAHPVVAPRADRGYRKLFLQSVTQADQGVDFDFLR 576
Cdd:PRK06131 480 VLHVAPEAAAGGPLALVRTGDRIRLDVPARRLDLLVSDEELARRRAAWPPPPPRAERGYQELYRDHVLQADEGCDFDFLV 559

                 ....*.
gi 500131844 577 APVTRA 582
Cdd:PRK06131 560 GYRGAP 565
 
Name Accession Description Interval E-value
PRK06131 PRK06131
dihydroxy-acid dehydratase; Validated
18-582 0e+00

dihydroxy-acid dehydratase; Validated


Pssm-ID: 235708  Cd Length: 571  Bit Score: 978.13  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844  18 AHGIAKGLPDYGDRGFSLFLRRAFIKGAGYTDAAL-GRPIIGIANTASAYNPCHGNAPQLIEAVKRGVLLAGGLPMDFPT 96
Cdd:PRK06131   1 TPGLLRSLAWFGDDDFRAFYHRSFMKNQGYPDELFdGRPIIGICNTWSDLNPCNAHFRQLAERVKRGVLEAGGFPVEFPV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844  97 ISVHESFSQPTSMYTRNLMSMDTEEMIRAQPMDAVVLIGGCDKTVPAQLMGAASAGIPAIALITGAMLTGAHRSQRVGAC 176
Cdd:PRK06131  81 ISLGESFLRPTAMLYRNLAAMDVEEMIRGYPIDGVVLLGGCDKTTPALLMGAASVDLPAIVLSGGPMLNGKHKGERLGSG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844 177 TDCRRYWARFRAGEIDAQEIADVNRQLVASVGTCSVMGTASTMACIAEALGMTVPGGASPPAVTADRIRVAEQTGAQAVA 256
Cdd:PRK06131 161 TDVWKYWEELRAGEIDLEEFLEAEAGMARSAGTCNTMGTASTMACMAEALGMSLPGNAAIPAVDARRIRMAELTGRRIVE 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844 257 MARSGLTIDKVLTARAFENAMRVLLAIGGSTNAIVHLTAIAGRMGYDIDLDAFDRMGRQTPVLLDLKPSGAHYMEDFHHA 336
Cdd:PRK06131 241 MVHEDLKPSDILTREAFENAIRVNAAIGGSTNAVIHLIAIAGRAGVELDLDDWDRIGRDVPVLVNLQPSGEYLMEDFYYA 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844 337 GGMATLLRELKPLLHLDALTVTGRTLGEEIERAgPGFAQQVVRPLERPIYPQGGIAVLQGNLAPGGAIIKQSTADAALME 416
Cdd:PRK06131 321 GGLPAVLRELGELLHLDALTVNGKTLGENLAGA-PVYNDDVIRPLDNPLKPEGGIAVLRGNLAPDGAVIKPSAASPELLK 399
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844 417 HEGRAVVFENAEDLARRIDSDGLDVTQADILVLKNIGPKGAPGMPEAGYIPIPRKLARAGVKDIVRISDGRMSGTAFGTI 496
Cdd:PRK06131 400 HEGRAVVFEGYEDYKARIDDPDLDVDEDTVLVLRNAGPKGYPGMPEVGNMPIPKKLLRQGVKDMVRISDARMSGTAYGTV 479
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844 497 VLHVTPEAAVGGPLAHVRNGDRIRLSVRERALTLLVDDQELARRASAHPVVAPRADRGYRKLFLQSVTQADQGVDFDFLR 576
Cdd:PRK06131 480 VLHVAPEAAAGGPLALVRTGDRIRLDVPARRLDLLVSDEELARRRAAWPPPPPRAERGYQELYRDHVLQADEGCDFDFLV 559

                 ....*.
gi 500131844 577 APVTRA 582
Cdd:PRK06131 560 GYRGAP 565
ILVD_EDD pfam00920
Dehydratase family;
54-569 0e+00

Dehydratase family;


Pssm-ID: 459998  Cd Length: 513  Bit Score: 694.84  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844   54 RPIIGIANTASAYNPCHGNAPQLIEAVKRGVLLAGGLPMDFPTISVHESFSQPT-----SMYTRNLMSMDTEEMIRAQPM 128
Cdd:pfam00920   1 KPIIGIANSYSDLVPCHVHLRELAEAVKEGVREAGGVPAEFNTIGVCDGIAMGHegmrySLPSRELIADSIEEMLRAHPF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844  129 DAVVLIGGCDKTVPAQLMGAASAGIPAIALITGAMLTGahrsqrvGACTDCRRYWARFRAGEIDAQEIADVNRQLVASVG 208
Cdd:pfam00920  81 DGLVLIGGCDKIVPGMLMAAARLNIPAIFVSGGPMLPG-------GSGTDEFEAVGAYAAGKISEEELLEIERAACPGCG 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844  209 TCSVMGTASTMACIAEALGMTVPGGASPPAVTADRIRVAEQTGAQAVAMARSGLTIDKVLTARAFENAMRVLLAIGGSTN 288
Cdd:pfam00920 154 SCGGMGTANTMACLAEALGLSLPGSATIPAVSAERLRLAREAGRRIVELVEEDIKPRDILTRKAFENAIVVDMALGGSTN 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844  289 AIVHLTAIAGRMGYDIDLDAFDRMGRQTPVLLDLKPSGAHYMEDFHHAGGMATLLRELKP-LLHLDALTVTGRTLGEEIE 367
Cdd:pfam00920 234 AVLHLLAIAREAGVDLTLDDFDRISRKVPLLADLKPSGKYLMEDFHRAGGVPAVLKELLDaLLHGDVLTVTGKTLGENLA 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844  368 RAGPgFAQQVVRPLERPIYPQGGIAVLQGNLAPGGAIIKQSTADAALMEHEGRAVVFENAEDLARRIDSDglDVTQADIL 447
Cdd:pfam00920 314 DAEV-RDQDVIRPLDNPISPTGGLAVLKGNLAPDGAVVKTSAVDPEMLVFEGPARVFDSEEDALAAILDG--KIKAGDVV 390
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844  448 VLKNIGPKGAPGMPEAgyIPIPRKLARAGV-KDIVRISDGRMSGTAFGTIVLHVTPEAAVGGPLAHVRNGDRIRLSVRER 526
Cdd:pfam00920 391 VIRYEGPKGGPGMPEM--LTPTSALLGAGLgKDVALITDGRFSGASRGPSIGHVSPEAAVGGPIALVRDGDIIRIDIPNR 468
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....
gi 500131844  527 ALTLLVDDQELA-RRASAHPVVAPRADRGYRKLFLQSVTQADQG 569
Cdd:pfam00920 469 TLDLLVSDEELAaRRAAWKPPEPKVKGRGYLAKYAKLVSSASEG 512
IlvD COG0129
Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism, ...
38-569 0e+00

Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism, Carbohydrate transport and metabolism]; Dihydroxyacid dehydratase/phosphogluconate dehydratase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 439899  Cd Length: 558  Bit Score: 526.88  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844  38 RRAFIKGAGYTDAALGRPIIGIANTASAYNPCHGNAPQLIEAVKRGVLLAGGLPMDFPTISV-------HE--SFSQPTs 108
Cdd:COG0129   18 ARALLRATGLTDEDFGKPIIGIANSWNEIVPGHVHLDDLAEAVKEGIRAAGGVPFEFNTIAVsdgiamgHEgmRYSLPS- 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844 109 mytRNLMSMDTEEMIRAQPMDAVVLIGGCDKTVPAQLMGAASAGIPAIALITGAMLTGAHRSQRVGAcTDCRRYWARFRA 188
Cdd:COG0129   97 ---RELIADSIETMVNAHCFDGLVCIPGCDKITPGMLMAAARLNIPSIFVYGGPMLPGKYDGKDLDI-VDVFEAVGAYAA 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844 189 GEIDAQEIADVNRQLVASVGTCSVMGTASTMACIAEALGMTVPGGASPPAVTADRIRVAEQTGAQAVAMARSGLTIDKVL 268
Cdd:COG0129  173 GKISDEELKEIERNACPGCGSCSGMFTANTMACLTEALGLSLPGSGTIPAVSAERRRLAREAGRRIVELVEKDIKPRDIL 252
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844 269 TARAFENAMRVLLAIGGSTNAIVHLTAIAGRMGYDIDLDAFDRMGRQTPVLLDLKPSGAHYMEDFHHAGGMATLLREL-- 346
Cdd:COG0129  253 TREAFENAIAVDMALGGSTNTVLHLLAIAHEAGVDLTLDDFDRISRRTPHLCDLKPSGKYHMEDLHRAGGIPAVMKELld 332
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844 347 KPLLHLDALTVTGRTLGEEIERAGPGFAQQVVRPLERPIYPQGGIAVLQGNLAPGGAIIKQSTADAALMEHEGRAVVFEN 426
Cdd:COG0129  333 AGLLHGDCLTVTGKTLAENLADADIDRDQDVIRPLDNPYSPTGGLAILRGNLAPDGAVVKTAGVDESMLVFEGPARVFDS 412
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844 427 AED-----LARRIDSDgldvtqaDILVLKNIGPKGAPGMPEA----GYIpiprklARAG-VKDIVRISDGRMSGTAFGTI 496
Cdd:COG0129  413 EEEaveaiLGGKIKAG-------DVVVIRYEGPKGGPGMREMlsptSAL------KGMGlGKSVALITDGRFSGGTRGLS 479
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 500131844 497 VLHVTPEAAVGGPLAHVRNGDRIRLSVRERALTLLVDDQELARRASAHPVVAPRADRGYRKLFLQSVTQADQG 569
Cdd:COG0129  480 IGHVSPEAAEGGPIALVEDGDIITIDIPARTLDLLVSDEELARRRAAWKPPEPRVTSGVLAKYAKLVSSASKG 552
 
Name Accession Description Interval E-value
PRK06131 PRK06131
dihydroxy-acid dehydratase; Validated
18-582 0e+00

dihydroxy-acid dehydratase; Validated


Pssm-ID: 235708  Cd Length: 571  Bit Score: 978.13  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844  18 AHGIAKGLPDYGDRGFSLFLRRAFIKGAGYTDAAL-GRPIIGIANTASAYNPCHGNAPQLIEAVKRGVLLAGGLPMDFPT 96
Cdd:PRK06131   1 TPGLLRSLAWFGDDDFRAFYHRSFMKNQGYPDELFdGRPIIGICNTWSDLNPCNAHFRQLAERVKRGVLEAGGFPVEFPV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844  97 ISVHESFSQPTSMYTRNLMSMDTEEMIRAQPMDAVVLIGGCDKTVPAQLMGAASAGIPAIALITGAMLTGAHRSQRVGAC 176
Cdd:PRK06131  81 ISLGESFLRPTAMLYRNLAAMDVEEMIRGYPIDGVVLLGGCDKTTPALLMGAASVDLPAIVLSGGPMLNGKHKGERLGSG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844 177 TDCRRYWARFRAGEIDAQEIADVNRQLVASVGTCSVMGTASTMACIAEALGMTVPGGASPPAVTADRIRVAEQTGAQAVA 256
Cdd:PRK06131 161 TDVWKYWEELRAGEIDLEEFLEAEAGMARSAGTCNTMGTASTMACMAEALGMSLPGNAAIPAVDARRIRMAELTGRRIVE 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844 257 MARSGLTIDKVLTARAFENAMRVLLAIGGSTNAIVHLTAIAGRMGYDIDLDAFDRMGRQTPVLLDLKPSGAHYMEDFHHA 336
Cdd:PRK06131 241 MVHEDLKPSDILTREAFENAIRVNAAIGGSTNAVIHLIAIAGRAGVELDLDDWDRIGRDVPVLVNLQPSGEYLMEDFYYA 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844 337 GGMATLLRELKPLLHLDALTVTGRTLGEEIERAgPGFAQQVVRPLERPIYPQGGIAVLQGNLAPGGAIIKQSTADAALME 416
Cdd:PRK06131 321 GGLPAVLRELGELLHLDALTVNGKTLGENLAGA-PVYNDDVIRPLDNPLKPEGGIAVLRGNLAPDGAVIKPSAASPELLK 399
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844 417 HEGRAVVFENAEDLARRIDSDGLDVTQADILVLKNIGPKGAPGMPEAGYIPIPRKLARAGVKDIVRISDGRMSGTAFGTI 496
Cdd:PRK06131 400 HEGRAVVFEGYEDYKARIDDPDLDVDEDTVLVLRNAGPKGYPGMPEVGNMPIPKKLLRQGVKDMVRISDARMSGTAYGTV 479
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844 497 VLHVTPEAAVGGPLAHVRNGDRIRLSVRERALTLLVDDQELARRASAHPVVAPRADRGYRKLFLQSVTQADQGVDFDFLR 576
Cdd:PRK06131 480 VLHVAPEAAAGGPLALVRTGDRIRLDVPARRLDLLVSDEELARRRAAWPPPPPRAERGYQELYRDHVLQADEGCDFDFLV 559

                 ....*.
gi 500131844 577 APVTRA 582
Cdd:PRK06131 560 GYRGAP 565
ILVD_EDD pfam00920
Dehydratase family;
54-569 0e+00

Dehydratase family;


Pssm-ID: 459998  Cd Length: 513  Bit Score: 694.84  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844   54 RPIIGIANTASAYNPCHGNAPQLIEAVKRGVLLAGGLPMDFPTISVHESFSQPT-----SMYTRNLMSMDTEEMIRAQPM 128
Cdd:pfam00920   1 KPIIGIANSYSDLVPCHVHLRELAEAVKEGVREAGGVPAEFNTIGVCDGIAMGHegmrySLPSRELIADSIEEMLRAHPF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844  129 DAVVLIGGCDKTVPAQLMGAASAGIPAIALITGAMLTGahrsqrvGACTDCRRYWARFRAGEIDAQEIADVNRQLVASVG 208
Cdd:pfam00920  81 DGLVLIGGCDKIVPGMLMAAARLNIPAIFVSGGPMLPG-------GSGTDEFEAVGAYAAGKISEEELLEIERAACPGCG 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844  209 TCSVMGTASTMACIAEALGMTVPGGASPPAVTADRIRVAEQTGAQAVAMARSGLTIDKVLTARAFENAMRVLLAIGGSTN 288
Cdd:pfam00920 154 SCGGMGTANTMACLAEALGLSLPGSATIPAVSAERLRLAREAGRRIVELVEEDIKPRDILTRKAFENAIVVDMALGGSTN 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844  289 AIVHLTAIAGRMGYDIDLDAFDRMGRQTPVLLDLKPSGAHYMEDFHHAGGMATLLRELKP-LLHLDALTVTGRTLGEEIE 367
Cdd:pfam00920 234 AVLHLLAIAREAGVDLTLDDFDRISRKVPLLADLKPSGKYLMEDFHRAGGVPAVLKELLDaLLHGDVLTVTGKTLGENLA 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844  368 RAGPgFAQQVVRPLERPIYPQGGIAVLQGNLAPGGAIIKQSTADAALMEHEGRAVVFENAEDLARRIDSDglDVTQADIL 447
Cdd:pfam00920 314 DAEV-RDQDVIRPLDNPISPTGGLAVLKGNLAPDGAVVKTSAVDPEMLVFEGPARVFDSEEDALAAILDG--KIKAGDVV 390
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844  448 VLKNIGPKGAPGMPEAgyIPIPRKLARAGV-KDIVRISDGRMSGTAFGTIVLHVTPEAAVGGPLAHVRNGDRIRLSVRER 526
Cdd:pfam00920 391 VIRYEGPKGGPGMPEM--LTPTSALLGAGLgKDVALITDGRFSGASRGPSIGHVSPEAAVGGPIALVRDGDIIRIDIPNR 468
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....
gi 500131844  527 ALTLLVDDQELA-RRASAHPVVAPRADRGYRKLFLQSVTQADQG 569
Cdd:pfam00920 469 TLDLLVSDEELAaRRAAWKPPEPKVKGRGYLAKYAKLVSSASEG 512
PRK13016 PRK13016
dihydroxy-acid dehydratase; Provisional
36-582 0e+00

dihydroxy-acid dehydratase; Provisional


Pssm-ID: 237271  Cd Length: 577  Bit Score: 653.33  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844  36 FLRRAFIKGAGYTDAAL-GRPIIGIANTASAYNPCHGNAPQLIEAVKRGVLLAGGLPMDFPTISVHESFSQPTSMYTRNL 114
Cdd:PRK13016  23 FGHRSRMMQMGYAPEDFdGKPVIAILNTWSDANPCHGHFRERVEDVKRGVLQAGGFPLELPALSLSENFVKPTTMLYRNL 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844 115 MSMDTEEMIRAQPMDAVVLIGGCDKTVPAQLMGAASAGIPAIALITGAMLTGAHRSQRVGACTDCRRYWARFRAGEIDAQ 194
Cdd:PRK13016 103 LAMETEELIRSHPVDGAVLMGGCDKTTPGLVMGAISMGLPMIYLPAGPMLRGNYRGKVLGSGSDAWKYWDERRAGNITQA 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844 195 EIADVNRQLVASVGTCSVMGTASTMACIAEALGMTVPGGASPPAVTADRIRVAEQTGAQAVAMARSGLTIDKVLTARAFE 274
Cdd:PRK13016 183 EWLEIEGGIARSYGTCMTMGTASTMTAIAEALGLTLPGASSIPAADANHQRMAALCGRRIVEMVWEDLTPSQILTKAAFE 262
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844 275 NAMRVLLAIGGSTNAIVHLTAIAGRMGYDIDLDAFDRMGRQTPVLLDLKPSGAHY-MEDFHHAGGMATLLRELKPLLHLD 353
Cdd:PRK13016 263 NAITVAMATGCSTNAVIHLIAMARRAGVPLSLDDLDRCGRTVPVIANIRPSGKTYlMEDFFYAGGLRALMKQLGDKLHLD 342
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844 354 ALTVTGRTLGEEIERAgPGFAQQVVRPLERPIYPQGGIAVLQGNLAPGGAIIKQSTADAALMEHEGRAVVFENAEDLARR 433
Cdd:PRK13016 343 ALTVTGKTLGDNLEGA-KVYNDDVIRPLDNPVYAEGSLAVLRGNLAPDGAVIKPAACDPKFLVHRGPALVFDSYPEMKAA 421
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844 434 IDSDGLDVTQADILVLKNIGPKGAPGMPEAGYIPIPRKLARAGVKDIVRISDGRMSGTAFGTIVLHVTPEAAVGGPLAHV 513
Cdd:PRK13016 422 IDDENLDVTPDHVMVLRNAGPQGGPGMPEWGMLPIPKKLLKQGVRDMVRISDARMSGTSYGACVLHVAPEAYVGGPLALV 501
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 500131844 514 RNGDRIRLSVRERALTLLVDDQELARRASAHPVVAPRADRGYRKLFLQSVTQADQGVDFDFLRAPVTRA 582
Cdd:PRK13016 502 RTGDIIELDVPARRLHLLVSDEELARRRAAWQPPERRYERGYGWMFSQHVEQADKGCDFDFLETGFGRA 570
PRK13017 PRK13017
dihydroxy-acid dehydratase; Provisional
46-575 0e+00

dihydroxy-acid dehydratase; Provisional


Pssm-ID: 237272  Cd Length: 596  Bit Score: 588.08  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844  46 GYTDAAL--GRPIIGIANTASAYNPCHGNAPQLIEAVKRGVLLAGGLPMDFPTISVHESFSQPTSMYTRNLMSMDTEEMI 123
Cdd:PRK13017  37 GLTREELqsGKPIIGIAQTGSDLSPCNRHHLELAERVKEGIRDAGGIPMEFPVHPIQETGKRPTAALDRNLAYLGLVEIL 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844 124 RAQPMDAVVLIGGCDKTVPAQLMGAASAGIPAIALITGAMLTGAHRSQRVGACTDCRRYWARFRAGEIDAQEIADVNRQL 203
Cdd:PRK13017 117 YGYPLDGVVLTTGCDKTTPACLMAAATVDLPAIVLSGGPMLDGWHEGERVGSGTVIWKARELLAAGEIDYEEFMELVASS 196
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844 204 VASVGTCSVMGTASTMACIAEALGMTVPGGASPPAVTADRIRVAEQTGAQAVAMARSGLTIDKVLTARAFENAMRVLLAI 283
Cdd:PRK13017 197 APSVGHCNTMGTASTMNALAEALGMSLPGCAAIPAPYRERGQMAYATGKRIVEMVWEDLKPSDILTREAFENAIVVNSAI 276
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844 284 GGSTNAIVHLTAIAGRMGYDIDLDAFDRMGRQTPVLLDLKPSGAHYMEDFHHAGGMATLLRELKP--LLHLDALTVTGRT 361
Cdd:PRK13017 277 GGSTNAPIHLIAIARHAGVELSLDDWQRVGEDVPLLVNLQPAGKYLGEDFHRAGGVPAVLAELLRagLLHGDALTVSGRT 356
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844 362 LGEEIERAgPGFAQQVVRPLERPIYPQGGIAVLQGNLApGGAIIKQSTADAALME-----------HEGRAVVFENAEDL 430
Cdd:PRK13017 357 IGENIAGA-PAPDRDVIRPYDAPLKERAGFLVLRGNLF-DSAIMKTSVISEEFRErylsepgdenaFEGRAVVFDGPEDY 434
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844 431 ARRIDSDGLDVTQADILVLKNIGPKGAPGMPEAGYIPIPRKLARAGVKDIVRISDGRMSGTAFGTIVLHVTPEAAVGGPL 510
Cdd:PRK13017 435 HARIDDPALDIDEHCILVIRGAGPVGYPGSAEVVNMQPPAALLKRGIRSLPCIGDGRQSGTSGSPSILNASPEAAVGGGL 514
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 500131844 511 AHVRNGDRIRLSVRERALTLLVDDQELARRASAHPVVAPRADRGYRKLFLQSVTQADQGVDFDFL 575
Cdd:PRK13017 515 ALLRTGDRIRIDLNKRRVDVLVSDEELARRRAALKPPVPPSQTPWQELYRKHVGQLSTGACLEPA 579
IlvD COG0129
Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism, ...
38-569 0e+00

Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism, Carbohydrate transport and metabolism]; Dihydroxyacid dehydratase/phosphogluconate dehydratase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 439899  Cd Length: 558  Bit Score: 526.88  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844  38 RRAFIKGAGYTDAALGRPIIGIANTASAYNPCHGNAPQLIEAVKRGVLLAGGLPMDFPTISV-------HE--SFSQPTs 108
Cdd:COG0129   18 ARALLRATGLTDEDFGKPIIGIANSWNEIVPGHVHLDDLAEAVKEGIRAAGGVPFEFNTIAVsdgiamgHEgmRYSLPS- 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844 109 mytRNLMSMDTEEMIRAQPMDAVVLIGGCDKTVPAQLMGAASAGIPAIALITGAMLTGAHRSQRVGAcTDCRRYWARFRA 188
Cdd:COG0129   97 ---RELIADSIETMVNAHCFDGLVCIPGCDKITPGMLMAAARLNIPSIFVYGGPMLPGKYDGKDLDI-VDVFEAVGAYAA 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844 189 GEIDAQEIADVNRQLVASVGTCSVMGTASTMACIAEALGMTVPGGASPPAVTADRIRVAEQTGAQAVAMARSGLTIDKVL 268
Cdd:COG0129  173 GKISDEELKEIERNACPGCGSCSGMFTANTMACLTEALGLSLPGSGTIPAVSAERRRLAREAGRRIVELVEKDIKPRDIL 252
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844 269 TARAFENAMRVLLAIGGSTNAIVHLTAIAGRMGYDIDLDAFDRMGRQTPVLLDLKPSGAHYMEDFHHAGGMATLLREL-- 346
Cdd:COG0129  253 TREAFENAIAVDMALGGSTNTVLHLLAIAHEAGVDLTLDDFDRISRRTPHLCDLKPSGKYHMEDLHRAGGIPAVMKELld 332
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844 347 KPLLHLDALTVTGRTLGEEIERAGPGFAQQVVRPLERPIYPQGGIAVLQGNLAPGGAIIKQSTADAALMEHEGRAVVFEN 426
Cdd:COG0129  333 AGLLHGDCLTVTGKTLAENLADADIDRDQDVIRPLDNPYSPTGGLAILRGNLAPDGAVVKTAGVDESMLVFEGPARVFDS 412
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844 427 AED-----LARRIDSDgldvtqaDILVLKNIGPKGAPGMPEA----GYIpiprklARAG-VKDIVRISDGRMSGTAFGTI 496
Cdd:COG0129  413 EEEaveaiLGGKIKAG-------DVVVIRYEGPKGGPGMREMlsptSAL------KGMGlGKSVALITDGRFSGGTRGLS 479
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 500131844 497 VLHVTPEAAVGGPLAHVRNGDRIRLSVRERALTLLVDDQELARRASAHPVVAPRADRGYRKLFLQSVTQADQG 569
Cdd:COG0129  480 IGHVSPEAAEGGPIALVEDGDIITIDIPARTLDLLVSDEELARRRAAWKPPEPRVTSGVLAKYAKLVSSASKG 552
PRK00911 PRK00911
dihydroxy-acid dehydratase; Provisional
39-569 2.77e-170

dihydroxy-acid dehydratase; Provisional


Pssm-ID: 234861  Cd Length: 552  Bit Score: 496.51  E-value: 2.77e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844  39 RAFIKGAGYTDAALGRPIIGIANTASAYNPCHGNAPQLIEAVKRGVLLAGGLPMDFPTISV-------HE--SFSQPTsm 109
Cdd:PRK00911  16 RSMLRATGLTDEDFDKPFIGIANSWNEITPCNIHLNELADAVKEGVRAAGGVPFEFNTIGVsdgiamgHEgmKYSLVS-- 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844 110 ytRNLMSMDTEEMIRAQPMDAVVLIGGCDKTVPAQLMGAASAGIPAIALITGAMLTGAHRSQR---------VGACTdcr 180
Cdd:PRK00911  94 --REVIADSIETVVNAHWFDGLVAIPGCDKNMPGMLMAAARLNVPSIFVYGGPILPGRLKGKDltlvsvfeaVGAYA--- 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844 181 rywarfrAGEIDAQEIADVNRQLVASVGTCSVMGTASTMACIAEALGMTVPGGASPPAVTADRIRVAEQTGAQAVAMARS 260
Cdd:PRK00911 169 -------AGKISEEELKEIERNACPGAGSCGGMFTANTMACLIEALGMSLPGSGTIPAVDAERDELAREAGEAVVELLEK 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844 261 GLTIDKVLTARAFENAMRVLLAIGGSTNAIVHLTAIAGRMGYDIDLDAFDRMGRQTPVLLDLKPSGAHYMEDFHHAGGMA 340
Cdd:PRK00911 242 DIKPRDILTREAFENAIAVDMALGGSTNAVLHLLAIAHEAGVDLTLDDFNRISKRTPHLADLKPSGKYVMEDLHEAGGIP 321
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844 341 TLLREL--KPLLHLDALTVTGRTLGEEIERAgPGFAQQVVRPLERPIYPQGGIAVLQGNLAPGGAIIKQStADAALMeHE 418
Cdd:PRK00911 322 AVMKELldAGLLHGDCLTVTGKTLAENLADA-PDPDQDVIRPLDNPISPTGGLAILKGNLAPEGAVVKIA-GVKPEM-FT 398
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844 419 GRAVVFENAEDLARRIDSDglDVTQADILVLKNIGPKGAPGMPE------AgyipiprkLARAGV-KDIVRISDGRMSGT 491
Cdd:PRK00911 399 GPARVFDSEEEAMEAILAG--KIKAGDVVVIRYEGPKGGPGMREmlaptsA--------IVGAGLgDDVALITDGRFSGG 468
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 500131844 492 AFGTIVLHVTPEAAVGGPLAHVRNGDRIRLSVRERALTLLVDDQELARRASAHPVVAPRADRGYRKLFLQSVTQADQG 569
Cdd:PRK00911 469 TRGLCVGHVSPEAAVGGPIALVEDGDIITIDAPNRTLDVLVSDEELARRRAAWKPPEPKYKRGVLAKYAKLVSSASTG 546
PRK12448 PRK12448
dihydroxy-acid dehydratase; Provisional
39-569 1.17e-84

dihydroxy-acid dehydratase; Provisional


Pssm-ID: 237104  Cd Length: 615  Bit Score: 277.11  E-value: 1.17e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844  39 RAFIKGAGYTDAALGRPIIGIANTASAYNPCHGNAPQLIEAVKRGVLLAGGLPMDFPTISV-------HES--FSQPTsm 109
Cdd:PRK12448  18 RALWRATGMKDEDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVddgiamgHGGmlYSLPS-- 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844 110 ytRNLMSMDTEEMIRAQPMDAVVLIGGCDKTVPAQLMGAASAGIPAIALITGAMLTGAHRSQRVGACTDCrrywarfrag 189
Cdd:PRK12448  96 --RELIADSVEYMVNAHCADAMVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKTKLSDKIIKLDL---------- 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844 190 eIDA-----------QEIADVNRQLVASVGTCSVMGTASTMACIAEALGMTVPGGASPPAVTADRIRVAEQTGAQAVAMA 258
Cdd:PRK12448 164 -VDAmvaaadpsvsdEDVAQIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSLLATHADRKQLFLEAGRRIVELA 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844 259 RS--GLTIDKVL-----TARAFENAMRVLLAIGGSTNAIVHLTAIAGRMGYDIDLDAFDRMGRQTPVLLDLKPSGAHY-M 330
Cdd:PRK12448 243 KRyyEQDDESVLprsiaTKAAFENAMTLDIAMGGSTNTVLHLLAAAQEAEVDFTMADIDRLSRKVPCLCKVAPNTQKYhM 322
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844 331 EDFHHAGGMATLLRELKP--LLHLDALTVTGRTLGEEIE----------------RAGPG-------FAQQ--------- 376
Cdd:PRK12448 323 EDVHRAGGIMGILGELDRagLLHTDVPTVHGLTLGEALDqwdimrtqdeavkeffRAAPGgirttvaFSQDcrwdsldtd 402
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844 377 ----VVRPLERPIYPQGGIAVLQGNLAPGGAIIKQSTADAALMEHEGRAVVFENAEDLARRIDSDglDVTQADILVLKNI 452
Cdd:PRK12448 403 rengCIRSVEHAYSKDGGLAVLYGNIAEDGCIVKTAGVDESILKFTGPARVFESQDDAVEAILGG--KVKAGDVVVIRYE 480
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500131844 453 GPKGAPGMPEAGYipiPRK-LARAGV-KDIVRISDGRMSGTAFGTIVLHVTPEAAVGGPLAHVRNGDRIRLSVRERALTL 530
Cdd:PRK12448 481 GPKGGPGMQEMLY---PTSyLKSKGLgKACALITDGRFSGGTSGLSIGHVSPEAASGGAIGLVEDGDIIEIDIPNRSINL 557
                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|..
gi 500131844 531 LVDDQELARRASA---------HPVVAPR----ADRGYRKLflqsVTQADQG 569
Cdd:PRK12448 558 LVSDEELAARRAAqeargdkawKPKNRERkvsfALKAYAAL----ATSADKG 605
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH