NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|500008990|ref|WP_011689708|]
View 

ATP-binding protein [Arthrobacter sp. FB24]

Protein Classification

sensor histidine kinase( domain architecture ID 1002947)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals

CATH:  3.30.565.10
EC:  2.7.13.3
Gene Ontology:  GO:0005524|GO:0007165|GO:0004673|GO:0000155
PubMed:  10637609|10339418
SCOP:  4001957

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
241-458 7.94e-60

Sensor histidine kinase WalK [Signal transduction mechanisms];


:

Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 201.32  E-value: 7.94e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 241 RLQASDQEQRRFVSDASHELRSPLATLSAGVEIAAADASG--ATWEHMKTVLAGETARMRYLVEDLLTLAKTNDGGLRLE 318
Cdd:COG5002  157 ELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAADdpEERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLE 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 319 TTDVDLDDVLNEEVRRLRSTSTR-----RIEASLEPSRITGDPRRLAQVIRNVLDNADRHAA--SRISITLRNTGSGAQI 391
Cdd:COG5002  237 KEPVDLAELLEEVVEELRPLAEEkgielELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPegGTITVSLREEDDQVRI 316

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 500008990 392 TIDNDGPPVPAADRERIFERFVRLDQSRSRESGGSGLGLAIAAGIMTAHHGWIRTGETLGGGCRFEL 458
Cdd:COG5002  317 SVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTI 383
HAMP smart00304
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
195-245 5.42e-05

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;


:

Pssm-ID: 197640 [Multi-domain]  Cd Length: 53  Bit Score: 40.69  E-value: 5.42e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 500008990   195 RSLRQVERIRGQVAGISARNLDGRVDVPpTSDEIQALAETMNMMLGRLQAS 245
Cdd:smart00304   2 RLLRPLRRLAEAAQRIADGDLTVRLPVD-GRDEIGELARAFNEMADRLEET 51
Tar super family cl43297
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
48-279 1.11e-03

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG0840:

Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 41.54  E-value: 1.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990  48 LVASTETAARRQAADVIAQISGQDVAEAGQYIVSTAHTGQYVQILTPGGAVFAASVPAAKTVALTSLRPGHGQTLTQDVS 127
Cdd:COG0840   57 LLLLLALALLLVLLALLLLLALVVLLALLLALLLLLLALLALALAALALLAALAALLALLELLLAALLAALAIALLALAA 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 128 GLPSLRDDDDFLIIATGADVGGRLYTVVVAATVQVQADTVSTVAWFILGATPLLLVVVGVSVWVLVGRSL-RQVERIRGQ 206
Cdd:COG0840  137 LLALAALALALLALALLAAAAAAAAALAALLEAAALALAAAALALALLAAALLALVALAIILALLLSRSItRPLRELLEV 216

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 500008990 207 VAGISARNLDGRVDVpPTSDEIQALAETMNMMLGRLQASDQEQRRF---VSDASHELRSPLATLSAGVEIAAADAS 279
Cdd:COG0840  217 LERIAEGDLTVRIDV-DSKDEIGQLADAFNRMIENLRELVGQVRESaeqVASASEELAASAEELAAGAEEQAASLE 291
 
Name Accession Description Interval E-value
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
241-458 7.94e-60

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 201.32  E-value: 7.94e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 241 RLQASDQEQRRFVSDASHELRSPLATLSAGVEIAAADASG--ATWEHMKTVLAGETARMRYLVEDLLTLAKTNDGGLRLE 318
Cdd:COG5002  157 ELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAADdpEERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLE 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 319 TTDVDLDDVLNEEVRRLRSTSTR-----RIEASLEPSRITGDPRRLAQVIRNVLDNADRHAA--SRISITLRNTGSGAQI 391
Cdd:COG5002  237 KEPVDLAELLEEVVEELRPLAEEkgielELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPegGTITVSLREEDDQVRI 316

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 500008990 392 TIDNDGPPVPAADRERIFERFVRLDQSRSRESGGSGLGLAIAAGIMTAHHGWIRTGETLGGGCRFEL 458
Cdd:COG5002  317 SVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTI 383
cztS_silS_copS TIGR01386
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...
 194-461 2.99e-46

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.


Pssm-ID: 273593 [Multi-domain]  Cd Length: 457  Bit Score: 166.79  E-value: 2.99e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990  194 GRSLRQVERIRGQVAGISARNLDGRVDVPPTSDEIQALAETMNMMLGRLQASDQEQRRFVSDASHELRSPLATLSAGVEI 273
Cdd:TIGR01386 186 RLGLEPLRRLSAVAARISPESLDQRLDPSRAPAELRELAQSFNAMLGRLEDAFQRLSQFSADLAHELRTPLTNLLGQTQV 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990  274 A-AADASGatwEHMKTVLAG---ETARMRYLVEDLLTLAKTNDGGLRLETTDVDLDDVLNE-----EVRRLRSTSTRRIE 344
Cdd:TIGR01386 266 AlSQPRTG---EEYREVLESnleELERLSRMVSDMLFLARADNGQLALERVRLDLAAELAKvaeyfEPLAEERGVRIRVE 342

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990  345 ASLepsRITGDPRRLAQVIRNVLDNADRHAA--SRISITLRNTGSGAQITIDNDGPPVPAADRERIFERFVRLDQSRSRE 422
Cdd:TIGR01386 343 GEG---LVRGDPQMFRRAISNLLSNALRHTPdgGTITVRIERRSDEVRVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNS 419

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 500008990  423 SGGSGLGLAIAAGIMTAHHGWIRTgETLGGGCRFELGFA 461
Cdd:TIGR01386 420 GEGTGLGLAIVRSIMEAHGGRASA-ESPDGKTRFILRFP 457
BaeS_SmeS NF012163
sensor histidine kinase efflux regulator BaeS;
195-460 6.26e-40

sensor histidine kinase efflux regulator BaeS;


Pssm-ID: 411086 [Multi-domain]  Cd Length: 457  Bit Score: 149.59  E-value: 6.26e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 195 RSLRQ-VERIRGQVAGISARNLDGRVdVPPTSDEIQALAETMNMMLGRLQASDQEQRRFVSDASHELRSPLATLSAGVEI 273
Cdd:NF012163 186 RGLLApVKRLVEATHRLAAGDYTTRV-TPTSNDELGKLAQDFNQLASTLEKNEQMRRDFMADISHELRTPLAVLRAELEA 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 274 AAADASGATWEHMkTVLAGETARMRYLVEDLLTLAKTNDGGLRLETTDVDLDDVLNEEVRRLR---STSTRRIEASLEPS 350
Cdd:NF012163 265 IQDGIRKFTPESL-DSLQAEVGTLTKLVDDLHDLSMSDEGALAYQKASVDLVPLLEVEGGAFRerfASAGLELEVSLPDS 343

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 351 R-ITGDPRRLAQVIRNVLDNADR--HAASRISITLRNTGSGAQITIDNDGPPVPAADRERIFERFVRLDQSRSRESGGSG 427
Cdd:NF012163 344 SlVFGDRDRLMQLFNNLLENSLRytDSGGSLHISASQRPKEVTLTVADSAPGVSDEQLARLFERFYRVEVSRNRASGGSG 423

                        250       260       270
                 ....*....|....*....|....*....|...
gi 500008990 428 LGLAIAAGIMTAHHGWIRTGETLGGGCRFELGF 460
Cdd:NF012163 424 LGLAISLNIVQAHGGTLHAAHSPLGGLRIVVTL 456
PRK09835 PRK09835
Cu(+)/Ag(+) sensor histidine kinase;
195-445 5.95e-36

Cu(+)/Ag(+) sensor histidine kinase;


Pssm-ID: 182101 [Multi-domain]  Cd Length: 482  Bit Score: 139.14  E-value: 5.95e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 195 RSLRQVERirgQVAGISARNLDGRVDVPPTSDEIQALAETMNMMLGRLQASDQEQRRFVSDASHELRSPLATLSAGVEIA 274
Cdd:PRK09835 211 APIRSVSR---QIQNITSKDLDVRLDPQTVPIELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQTEIA 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 275 AADASgaTWEHMKTVLAG---ETARMRYLVEDLLTLAKTNDGGLRLETTDVDL-DDVLNEEVRRLRSTSTRRIEASLE-- 348
Cdd:PRK09835 288 LSQSR--SQKELEDVLYSnleELTRMAKMVSDMLFLAQADNNQLIPEKKMLDLaDEVGKVFDFFEAWAEERGVELRFVgd 365

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 349 PSRITGDPRRLAQVIRNVLDNADRH--AASRISITLRNTGSGAQITIDNDGPPVPAADRERIFERFVRLDQSRSRESGGS 426
Cdd:PRK09835 366 PCQVAGDPLMLRRAISNLLSNALRYtpAGEAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGS 445

                        250
                 ....*....|....*....
gi 500008990 427 GLGLAIAAGIMTAHHGWIR 445
Cdd:PRK09835 446 GIGLAIVKSIVVAHKGTVA 464
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 354-458 3.05e-28

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 108.12  E-value: 3.05e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990   354 GDPRRLAQVIRNVLDNADRHA--ASRISITLRNTGSGAQITIDNDGPPVPAADRERIFERFVRLDQsRSRESGGSGLGLA 431
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTpeGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGLS 79

                           90       100
                   ....*....|....*....|....*..
gi 500008990   432 IAAGIMTAHHGWIRTGETLGGGCRFEL 458
Cdd:smart00387  80 IVKKLVELHGGEISVESEPGGGTTFTI 106
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 359-458 1.09e-26

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 103.66  E-value: 1.09e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 359 LAQVIRNVLDNADRHAASRISITLRNTGSGAQITIDNDGPPVPAADRERIFERFVRLDQSRSRESGGSGLGLAIAAGIMT 438
Cdd:cd16939    1 MARALDNLLRNALRYAHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRVAL 80

                         90       100
                 ....*....|....*....|
gi 500008990 439 AHHGWIRTGETLGGGCRFEL 458
Cdd:cd16939   81 WHGGHVECDDSELGGACFRL 100
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 354-458 2.43e-24

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 97.05  E-value: 2.43e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990  354 GDPRRLAQVIRNVLDNADRHA--ASRISITLRnTGSGAQITIDNDGPPVPAADRERIFERFVRLDqsrSRESGGSGLGLA 431
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAakAGEITVTLS-EGGELTLTVEDNGIGIPPEDLPRIFEPFSTAD---KRGGGGTGLGLS 76

                          90       100
                  ....*....|....*....|....*..
gi 500008990  432 IAAGIMTAHHGWIRTGETLGGGCRFEL 458
Cdd:pfam02518  77 IVRKLVELLGGTITVESEPGGGTTVTL 103
HAMP smart00304
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
195-245 5.42e-05

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;


Pssm-ID: 197640 [Multi-domain]  Cd Length: 53  Bit Score: 40.69  E-value: 5.42e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 500008990   195 RSLRQVERIRGQVAGISARNLDGRVDVPpTSDEIQALAETMNMMLGRLQAS 245
Cdd:smart00304   2 RLLRPLRRLAEAAQRIADGDLTVRLPVD-GRDEIGELARAFNEMADRLEET 51
HAMP cd06225
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ...
 197-242 8.69e-04

Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.


Pssm-ID: 381743 [Multi-domain]  Cd Length: 45  Bit Score: 37.04  E-value: 8.69e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 500008990 197 LRQVERIRGQVAGISARNLDGRVDVPpTSDEIQALAETMNMMLGRL 242
Cdd:cd06225    1 TRPLRRLTEAARRIAEGDLDVRVPVR-SKDEIGELARAFNQMAERL 45
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
48-279 1.11e-03

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 41.54  E-value: 1.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990  48 LVASTETAARRQAADVIAQISGQDVAEAGQYIVSTAHTGQYVQILTPGGAVFAASVPAAKTVALTSLRPGHGQTLTQDVS 127
Cdd:COG0840   57 LLLLLALALLLVLLALLLLLALVVLLALLLALLLLLLALLALALAALALLAALAALLALLELLLAALLAALAIALLALAA 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 128 GLPSLRDDDDFLIIATGADVGGRLYTVVVAATVQVQADTVSTVAWFILGATPLLLVVVGVSVWVLVGRSL-RQVERIRGQ 206
Cdd:COG0840  137 LLALAALALALLALALLAAAAAAAAALAALLEAAALALAAAALALALLAAALLALVALAIILALLLSRSItRPLRELLEV 216

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 500008990 207 VAGISARNLDGRVDVpPTSDEIQALAETMNMMLGRLQASDQEQRRF---VSDASHELRSPLATLSAGVEIAAADAS 279
Cdd:COG0840  217 LERIAEGDLTVRIDV-DSKDEIGQLADAFNRMIENLRELVGQVRESaeqVASASEELAASAEELAAGAEEQAASLE 291
HAMP pfam00672
HAMP domain;
194-244 1.34e-03

HAMP domain;


Pssm-ID: 459898 [Multi-domain]  Cd Length: 53  Bit Score: 36.83  E-value: 1.34e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 500008990  194 GRSLRQVERIRGQVAGISARNLDGRVDVPpTSDEIQALAETMNMMLGRLQA 244
Cdd:pfam00672   4 RRILRPLRRLAEAARRIASGDLDVRLPVS-GRDEIGELARAFNQMAERLRE 53
 
Name Accession Description Interval E-value
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
241-458 7.94e-60

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 201.32  E-value: 7.94e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 241 RLQASDQEQRRFVSDASHELRSPLATLSAGVEIAAADASG--ATWEHMKTVLAGETARMRYLVEDLLTLAKTNDGGLRLE 318
Cdd:COG5002  157 ELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAADdpEERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLE 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 319 TTDVDLDDVLNEEVRRLRSTSTR-----RIEASLEPSRITGDPRRLAQVIRNVLDNADRHAA--SRISITLRNTGSGAQI 391
Cdd:COG5002  237 KEPVDLAELLEEVVEELRPLAEEkgielELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPegGTITVSLREEDDQVRI 316

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 500008990 392 TIDNDGPPVPAADRERIFERFVRLDQSRSRESGGSGLGLAIAAGIMTAHHGWIRTGETLGGGCRFEL 458
Cdd:COG5002  317 SVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTI 383
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
140-458 3.33e-55

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 187.42  E-value: 3.33e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 140 IIATGADVGGRLYTVVVAATVQVQADTVSTVAWFILGATPLLLVVVGVSVWVLVGRSLRQVERIRGQVAGISARNLDGRV 219
Cdd:COG0642    1 LLLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 220 DVPPTSDEIQALAETMNMMLGRLQASDQEQRRFVSDASHELRSPLATLSAGVEIAAADASGATWEHMKTVLAgETARMRY 299
Cdd:COG0642   81 LLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEEQREYLETILR-SADRLLR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 300 LVEDLLTLAKTNDGGLRLETTDVDLDDVLNEEVRRLRSTSTR-----RIEASLEPSRITGDPRRLAQVIRNVLDNADRHA 374
Cdd:COG0642  160 LINDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEkgielELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYT 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 375 A--SRISITLRNTGSGAQITIDNDGPPVPAADRERIFERFVRLDqsRSRESGGSGLGLAIAAGIMTAHHGWIRTGETLGG 452
Cdd:COG0642  240 PegGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTD--PSRRGGGTGLGLAIVKRIVELHGGTIEVESEPGK 317


                 ....*.
gi 500008990 453 GCRFEL 458
Cdd:COG0642  318 GTTFTV 323
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
241-458 7.46e-54

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 180.87  E-value: 7.46e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 241 RLQASDQEQRRFVSDASHELRSPLATLSAGVEIAAADASGATWEHMKTV--LAGETARMRYLVEDLLTLAKTNDGGLRLE 318
Cdd:COG2205    8 ELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLeiIRESAERLLRLIEDLLDLSRLESGKLSLE 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 319 TTDVDLDDVLNE---EVRRLRSTSTRRIEASLEPS--RITGDPRRLAQVIRNVLDNADRH--AASRISITLRNTGSGAQI 391
Cdd:COG2205   88 LEPVDLAELLEEaveELRPLAEEKGIRLELDLPPElpLVYADPELLEQVLANLLDNAIKYspPGGTITISARREGDGVRI 167

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 500008990 392 TIDNDGPPVPAADRERIFERFVRLDqsRSRESGGSGLGLAIAAGIMTAHHGWIRTGETLGGGCRFEL 458
Cdd:COG2205  168 SVSDNGPGIPEEELERIFERFYRGD--NSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTV 232
cztS_silS_copS TIGR01386
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...
 194-461 2.99e-46

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.


Pssm-ID: 273593 [Multi-domain]  Cd Length: 457  Bit Score: 166.79  E-value: 2.99e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990  194 GRSLRQVERIRGQVAGISARNLDGRVDVPPTSDEIQALAETMNMMLGRLQASDQEQRRFVSDASHELRSPLATLSAGVEI 273
Cdd:TIGR01386 186 RLGLEPLRRLSAVAARISPESLDQRLDPSRAPAELRELAQSFNAMLGRLEDAFQRLSQFSADLAHELRTPLTNLLGQTQV 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990  274 A-AADASGatwEHMKTVLAG---ETARMRYLVEDLLTLAKTNDGGLRLETTDVDLDDVLNE-----EVRRLRSTSTRRIE 344
Cdd:TIGR01386 266 AlSQPRTG---EEYREVLESnleELERLSRMVSDMLFLARADNGQLALERVRLDLAAELAKvaeyfEPLAEERGVRIRVE 342

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990  345 ASLepsRITGDPRRLAQVIRNVLDNADRHAA--SRISITLRNTGSGAQITIDNDGPPVPAADRERIFERFVRLDQSRSRE 422
Cdd:TIGR01386 343 GEG---LVRGDPQMFRRAISNLLSNALRHTPdgGTITVRIERRSDEVRVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNS 419

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 500008990  423 SGGSGLGLAIAAGIMTAHHGWIRTgETLGGGCRFELGFA 461
Cdd:TIGR01386 420 GEGTGLGLAIVRSIMEAHGGRASA-ESPDGKTRFILRFP 457
BaeS_SmeS NF012163
sensor histidine kinase efflux regulator BaeS;
195-460 6.26e-40

sensor histidine kinase efflux regulator BaeS;


Pssm-ID: 411086 [Multi-domain]  Cd Length: 457  Bit Score: 149.59  E-value: 6.26e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 195 RSLRQ-VERIRGQVAGISARNLDGRVdVPPTSDEIQALAETMNMMLGRLQASDQEQRRFVSDASHELRSPLATLSAGVEI 273
Cdd:NF012163 186 RGLLApVKRLVEATHRLAAGDYTTRV-TPTSNDELGKLAQDFNQLASTLEKNEQMRRDFMADISHELRTPLAVLRAELEA 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 274 AAADASGATWEHMkTVLAGETARMRYLVEDLLTLAKTNDGGLRLETTDVDLDDVLNEEVRRLR---STSTRRIEASLEPS 350
Cdd:NF012163 265 IQDGIRKFTPESL-DSLQAEVGTLTKLVDDLHDLSMSDEGALAYQKASVDLVPLLEVEGGAFRerfASAGLELEVSLPDS 343

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 351 R-ITGDPRRLAQVIRNVLDNADR--HAASRISITLRNTGSGAQITIDNDGPPVPAADRERIFERFVRLDQSRSRESGGSG 427
Cdd:NF012163 344 SlVFGDRDRLMQLFNNLLENSLRytDSGGSLHISASQRPKEVTLTVADSAPGVSDEQLARLFERFYRVEVSRNRASGGSG 423

                        250       260       270
                 ....*....|....*....|....*....|...
gi 500008990 428 LGLAIAAGIMTAHHGWIRTGETLGGGCRFELGF 460
Cdd:NF012163 424 LGLAISLNIVQAHGGTLHAAHSPLGGLRIVVTL 456
PRK09835 PRK09835
Cu(+)/Ag(+) sensor histidine kinase;
195-445 5.95e-36

Cu(+)/Ag(+) sensor histidine kinase;


Pssm-ID: 182101 [Multi-domain]  Cd Length: 482  Bit Score: 139.14  E-value: 5.95e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 195 RSLRQVERirgQVAGISARNLDGRVDVPPTSDEIQALAETMNMMLGRLQASDQEQRRFVSDASHELRSPLATLSAGVEIA 274
Cdd:PRK09835 211 APIRSVSR---QIQNITSKDLDVRLDPQTVPIELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQTEIA 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 275 AADASgaTWEHMKTVLAG---ETARMRYLVEDLLTLAKTNDGGLRLETTDVDL-DDVLNEEVRRLRSTSTRRIEASLE-- 348
Cdd:PRK09835 288 LSQSR--SQKELEDVLYSnleELTRMAKMVSDMLFLAQADNNQLIPEKKMLDLaDEVGKVFDFFEAWAEERGVELRFVgd 365

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 349 PSRITGDPRRLAQVIRNVLDNADRH--AASRISITLRNTGSGAQITIDNDGPPVPAADRERIFERFVRLDQSRSRESGGS 426
Cdd:PRK09835 366 PCQVAGDPLMLRRAISNLLSNALRYtpAGEAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGS 445

                        250
                 ....*....|....*....
gi 500008990 427 GLGLAIAAGIMTAHHGWIR 445
Cdd:PRK09835 446 GIGLAIVKSIVVAHKGTVA 464
PRK10604 PRK10604
sensor protein RstB; Provisional
 215-458 1.79e-35

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 136.66  E-value: 1.79e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 215 LDGRVDVPPTSdEIQALAETMNMMLGRLQASDQEQRRFVSDASHELRSPLATLSAGVEIA---AADASGAtwehmktvLA 291
Cdd:PRK10604 179 LAERIHFDEGS-SLERLGVAFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLEMSdnlSAAESQA--------LN 249

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 292 GETARMRYLVEDLLTLAKTNDGGLRLETTDVDLDDVLNE---EVRRLRSTSTRRIEASLEPSRITGDPRRLAQVIRNVLD 368
Cdd:PRK10604 250 RDIGQLEALIEELLTYARLDRPQNELHLSEPDLPAWLSThlaDIQAVTPEKTVRLDTPHQGDYGALDMRLMERVLDNLLN 329

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 369 NADRHAASRISITLRNTGSGAQITIDNDGPPVPAADRERIFERFVRLDQSRSRESGGSGLGLAIAAGIMTAHHGWIRTGE 448
Cdd:PRK10604 330 NALRYAHSRVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDE 409

                        250
                 ....*....|
gi 500008990 449 TLGGGCRFEL 458
Cdd:PRK10604 410 SELGGARFSF 419
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 110-456 5.58e-33

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 131.06  E-value: 5.58e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 110 ALTSLRPGHGQTLTQDVSGLPSLRDDDDFLIIATGADVGGRLYTVVVAATVQVQADTVSTVAWFILGATPLLLVVVGVSV 189
Cdd:COG4251  139 ELALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELL 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 190 WVLVGRSLRQVERIRGQVAGISARNLDGRVDVPPTSDEIQALAETMNMMLGR----LQASDQEQRRFVSDASHELRSPLA 265
Cdd:COG4251  219 LSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEErtaeLERSNEELEQFAYVASHDLREPLR 298

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 266 TLSAGVEIAAADASGA----TWEHMKTVLAGeTARMRYLVEDLLTLAKTNDGGLRLETTDVD--LDDVLnEEVRRLRSTS 339
Cdd:COG4251  299 KISGFSQLLEEDYGDKldeeGREYLERIRDA-AERMQALIDDLLAYSRVGRQELEFEPVDLNelLEEVL-EDLEPRIEER 376

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 340 TRRIEASLEPsRITGDPRRLAQVIRNVLDNA----DRHAASRISITLRNTGSGAQITIDNDGPPVPAADRERIFERFVRL 415
Cdd:COG4251  377 GAEIEVGPLP-TVRGDPTLLRQVFQNLISNAikysRPGEPPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRL 455

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 500008990 416 DqsRSRESGGSGLGLAIAAGIMTAHHGWIRTGETLGGGCRF 456
Cdd:COG4251  456 H--SRDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEGATF 494
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
227-458 2.45e-31

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 125.81  E-value: 2.45e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 227 EIQALAETMNMMLGRLQASDQEQRRFVSDASHELRSPLATLsagveiaaadasgatweHMKTVLA--------------G 292
Cdd:PRK09470 221 EFRQAGASFNQMVTALERMMTSQQRLLSDISHELRTPLTRL-----------------QLATALLrrrqgeskelerieT 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 293 ETARMRYLVEDLLTLAKTN-DGGLRLETTDVDL--DDVLNE-EVRRLRSTSTRRIEASLEPSRITGDPRRLAQVIRNVLD 368
Cdd:PRK09470 284 EAQRLDSMINDLLVLSRNQqKNHLERETFKANSlwSEVLEDaKFEAEQMGKSLTVSAPPGPWPINGNPNALASALENIVR 363

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 369 NADRHAASRISITLRNTGSGAQITIDNDGPPVPAADRERIFERFVRLDQSRSRESGGSGLGLAIAAGIMTAHHGWIRTGE 448
Cdd:PRK09470 364 NALRYSHTKIEVAFSVDKDGLTITVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVKAED 443

                        250
                 ....*....|
gi 500008990 449 TLGGGCRFEL 458
Cdd:PRK09470 444 SPLGGLRLTI 453
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
197-455 9.16e-31

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 123.97  E-value: 9.16e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 197 LRQVERIrgqVAGI---SARNLDGRVDvPPTSDEIQALAETMNMMLGRLQASDQEQRRFVSDASHELRSPLATLSAGVEi 273
Cdd:PRK10549 189 LAPVKRL---VEGThklAAGDFTTRVT-PTSRDELGRLAQDFNQLASTLEKNEQMRRDFMADISHELRTPLAVLRGELE- 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 274 AAADASGATWEHMKTVLAGETARMRYLVEDLLTLAKTNDGGLRLETTDVDLDDVLneEVRRLR-----STSTRRIEASLE 348
Cdd:PRK10549 264 AIQDGVRKFTPESVASLQAEVGTLTKLVDDLHQLSLSDEGALAYRKTPVDLVPLL--EVAGGAfrerfASRGLTLQLSLP 341

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 349 PS-RITGDPRRLAQVIRNVLDNADRHAAS--RISITLRNTGSGAQITIDNDGPPVPAADRERIFERFVRLDQSRSRESGG 425
Cdd:PRK10549 342 DSaTVFGDPDRLMQLFNNLLENSLRYTDSggSLHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGSRNRASGG 421

                        250       260       270
                 ....*....|....*....|....*....|
gi 500008990 426 SGLGLAIAAGIMTAHHGWIRTGETLGGGCR 455
Cdd:PRK10549 422 SGLGLAICLNIVEAHNGRIIAAHSPFGGVS 451
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 354-458 3.05e-28

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 108.12  E-value: 3.05e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990   354 GDPRRLAQVIRNVLDNADRHA--ASRISITLRNTGSGAQITIDNDGPPVPAADRERIFERFVRLDQsRSRESGGSGLGLA 431
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTpeGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGLS 79

                           90       100
                   ....*....|....*....|....*..
gi 500008990   432 IAAGIMTAHHGWIRTGETLGGGCRFEL 458
Cdd:smart00387  80 IVKKLVELHGGEISVESEPGGGTTFTI 106
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 257-466 8.03e-27

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 111.98  E-value: 8.03e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 257 SHELRSPLATLSAGVEIAAADASGATWEHMKTVLAG------ETARMRYLVEDLLTLAKTndggLRLETTDVDLDDVLNE 330
Cdd:COG5000  209 AHEIKNPLTPIQLSAERLRRKLADKLEEDREDLERAldtiirQVDRLKRIVDEFLDFARL----PEPQLEPVDLNELLRE 284

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 331 ---EVRRLRSTSTRRIEASLEPS--RITGDPRRLAQVIRNVLDNAdRHAAS---RISITLRNTGSGAQITIDNDGPPVPA 402
Cdd:COG5000  285 vlaLYEPALKEKDIRLELDLDPDlpEVLADRDQLEQVLINLLKNA-IEAIEeggEIEVSTRREDGRVRIEVSDNGPGIPE 363

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 500008990 403 ADRERIFERFVrldqsrSRESGGSGLGLAIAAGIMTAHHGWIRTGETLGGGCRFELGFAPAPEP 466
Cdd:COG5000  364 EVLERIFEPFF------TTKPKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPLAEEA 421
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 195-458 8.67e-27

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 112.63  E-value: 8.67e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 195 RSLRQVERIRGQVAgisarnlDGRVDVPPT--SDEIQALAETMNMMLGRLqASDQEQRRFVSDASHELRSPLATLSAGVE 272
Cdd:PRK11100 208 RSIRRLTRYADAVT-------EGKPVPLPKlgSSELRELAQALESMRVKL-EGKAYVEQYVQTLTHELKSPLAAIRGAAE 279

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 273 IAAADASGATWEHMKTVLAGETARMRYLVEDLLTLAKTNDGGLRLETTDVDLDDVLNEEVRRLRSTSTR---RIEASLEP 349
Cdd:PRK11100 280 LLQEDPPPEDRARFTGNILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLEELVEAREAQAAAkgiTLRLRPDD 359

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 350 SRITGDPRRLAQVIRNVLDNA-D-RHAASRISITLRNTGSGAQITIDNDGPPVPAADRERIFERF---VRLDQSRSresg 424
Cdd:PRK11100 360 ARVLGDPFLLRQALGNLLDNAiDfSPEGGTITLSAEVDGEQVALSVEDQGPGIPDYALPRIFERFyslPRPANGRK---- 435

                        250       260       270
                 ....*....|....*....|....*....|....
gi 500008990 425 GSGLGLAIAAGIMTAHHGWIRTGETLGGGCRFEL 458
Cdd:PRK11100 436 STGLGLAFVREVARLHGGEVTLRNRPEGGVLATL 469
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 359-458 1.09e-26

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 103.66  E-value: 1.09e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 359 LAQVIRNVLDNADRHAASRISITLRNTGSGAQITIDNDGPPVPAADRERIFERFVRLDQSRSRESGGSGLGLAIAAGIMT 438
Cdd:cd16939    1 MARALDNLLRNALRYAHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRVAL 80

                         90       100
                 ....*....|....*....|
gi 500008990 439 AHHGWIRTGETLGGGCRFEL 458
Cdd:cd16939   81 WHGGHVECDDSELGGACFRL 100
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
250-456 1.15e-26

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 111.64  E-value: 1.15e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 250 RRFVSDASHELRSPLATLSAGVEIAA-ADASGATWEHMKTVLAGETARMRYLVEDLLTLAKtndgglrLET-TDVDLDDV 327
Cdd:PRK11006 205 RNFFANVSHELRTPLTVLQGYLEMMQdQPLEGALREKALHTMREQTQRMEGLVKQLLTLSK-------IEAaPTIDLNEK 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 328 LN--------EEVRRLRSTSTRRIEASLEPS-RITGDPRRLAQVIRNVLDNADRH--AASRISITLRNTGSGAQITIDND 396
Cdd:PRK11006 278 VDvpmmlrvlEREAQTLSQGKHTITFEVDNSlKVFGNEDQLRSAISNLVYNAVNHtpEGTHITVRWQRVPQGAEFSVEDN 357

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 397 GPPVPAADRERIFERFVRLDQSRSRESGGSGLGLAIAAGIMTAHHGWIRTGETLGGGCRF 456
Cdd:PRK11006 358 GPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRF 417
PRK10337 PRK10337
sensor protein QseC; Provisional
 227-453 3.34e-26

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 110.51  E-value: 3.34e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 227 EIQALAETMNMMLGRLQASDQEQRRFVSDASHELRSPLATLSAGVEIAA-ADASGATWEHMKTVLAGETARMRYLVEDLL 305
Cdd:PRK10337 215 EVRPLVEALNQLFARTHAMMVRERRFTSDAAHELRSPLAALKVQTEVAQlSDDDPQARKKALLQLHAGIDRATRLVDQLL 294

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 306 TLAKTNDGGLRLETTDVDLDDVLNEEVRRL-RSTSTRRIEASLE----PSRITGDPRRLAQVIRNVLDNADR--HAASRI 378
Cdd:PRK10337 295 TLSRLDSLDNLQDVAEIPLEDLLQSAVMDIyHTAQQAGIDVRLTlnahPVIRTGQPLLLSLLVRNLLDNAIRysPQGSVV 374

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 500008990 379 SITLRNTGsgaqITIDNDGPPVPAADRERIFERFVRldqSRSRESGGSGLGLAIAAGIMTAHHGWIRTGETLGGG 453
Cdd:PRK10337 375 DVTLNARN----FTVRDNGPGVTPEALARIGERFYR---PPGQEATGSGLGLSIVRRIAKLHGMNVSFGNAPEGG 442
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 359-445 4.59e-26

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 101.63  E-value: 4.59e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 359 LAQVIRNVLDNADRHAASRISITLRNTGSGAQITIDNDGPPVPAADRERIFERFVRLDQSRSRESGGSGLGLAIAAGIMT 438
Cdd:cd16949    1 LARALENVLRNALRYSPSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERAIE 80


                 ....*..
gi 500008990 439 AHHGWIR 445
Cdd:cd16949   81 QHGGKIK 87
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 354-458 2.43e-24

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 97.05  E-value: 2.43e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990  354 GDPRRLAQVIRNVLDNADRHA--ASRISITLRnTGSGAQITIDNDGPPVPAADRERIFERFVRLDqsrSRESGGSGLGLA 431
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAakAGEITVTLS-EGGELTLTVEDNGIGIPPEDLPRIFEPFSTAD---KRGGGGTGLGLS 76

                          90       100
                  ....*....|....*....|....*..
gi 500008990  432 IAAGIMTAHHGWIRTGETLGGGCRFEL 458
Cdd:pfam02518  77 IVRKLVELLGGTITVESEPGGGTTVTL 103
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
258-470 3.29e-24

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 103.39  E-value: 3.29e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 258 HELRSPLATLSAGVEIAAADASGATWEHMKTVLAGETARMRYLVEDLLTLAKTNdgglRLETTDVDLDDVLNE--EVRRL 335
Cdd:COG3852  144 HEIRNPLTGIRGAAQLLERELPDDELREYTQLIIEEADRLNNLVDRLLSFSRPR----PPEREPVNLHEVLERvlELLRA 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 336 RSTSTRRIEASLEPS--RITGDPRRLAQVIRNVLDNAdRHAAS---RISITLRN----------TGSGAQITIDNDGPPV 400
Cdd:COG3852  220 EAPKNIRIVRDYDPSlpEVLGDPDQLIQVLLNLVRNA-AEAMPeggTITIRTRVerqvtlgglrPRLYVRIEVIDNGPGI 298

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 401 PAADRERIFERFVrldqsrSRESGGSGLGLAIAAGIMTAHHGWIRTGETLGGGCRFELGFaPAPEPRQPK 470
Cdd:COG3852  299 PEEILDRIFEPFF------TTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYL-PLEQAEEEP 361
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
211-442 5.79e-24

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 102.74  E-value: 5.79e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 211 SARNLDgRVDVPPTSDEIQALAETMNMMLGRLQASDQEQRRFVSDASHELRSPLATLSAGVEIAA----ADASgatwehm 286
Cdd:PRK10755 100 TADNLT-PIAIHSSTLEIEAVTSALNQLVSRLTSTLDQERLFTADVAHELRTPLAGIRLHLELLEkqhhIDVA------- 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 287 ktVLAGETARMRYLVEDLLTLAKTND---GGLRletTDVDL-DDV---LNEEVRRLRSTSTRRIEASLEPSRIT--GDPR 357
Cdd:PRK10755 172 --PLIARLDQMMHTVEQLLQLARAGQsfsSGHY---QTVKLlEDVilpSQDELSEMLEQRQQTLLLPESAADITvqGDAT 246

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 358 RLAQVIRNVLDNADRHA--ASRISITLRNTGSGAQITIDNDGPPVPAADRERIFERFVRLDQsrsrESGGSGLGLAIAAG 435
Cdd:PRK10755 247 LLRLLLRNLVENAHRYSpeGSTITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFVRMDS----RYGGIGLGLSIVSR 322


                 ....*..
gi 500008990 436 IMTAHHG 442
Cdd:PRK10755 323 ITQLHHG 329
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 258-458 8.79e-24

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 102.18  E-value: 8.79e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 258 HELRSPLATLSAGVEIAAAD-ASGATWEHMKTVLA---GETARMRYLVEDLLTLAKTNDgglrLETTDVDLDDVLNE--- 330
Cdd:COG4191  151 HEINNPLAAILGNAELLRRRlEDEPDPEELREALErilEGAERAAEIVRSLRAFSRRDE----EEREPVDLNELIDEale 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 331 EVRRLRSTSTRRIEASLEPS--RITGDPRRLAQVIRNVLDNAdRHA-----ASRISITLRNTGSGAQITIDNDGPPVPAA 403
Cdd:COG4191  227 LLRPRLKARGIEVELDLPPDlpPVLGDPGQLEQVLLNLLINA-IDAmeegeGGRITISTRREGDYVVISVRDNGPGIPPE 305

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 500008990 404 DRERIFERFVrldqSRSRESGGSGLGLAIAAGIMTAHHGWIRTGETLGGGCRFEL 458
Cdd:COG4191  306 VLERIFEPFF----TTKPVGKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTI 356
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 355-460 4.39e-22

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 90.99  E-value: 4.39e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 355 DPRRLAQVIRNVLDNADR--HAASRISITLRNTGSGAQITIDNDGPPVPAADRERIFERFVRLDQSRSRESGGSGLGLAI 432
Cdd:cd16946    1 DRDRLQQLFVNLLENSLRytDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAI 80

                         90       100
                 ....*....|....*....|....*...
gi 500008990 433 AAGIMTAHHGWIRTGETLGGGCRFELGF 460
Cdd:cd16946   81 CHNIALAHGGTISAEHSPLGGLRLVLTL 108
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 343-460 1.97e-21

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 90.00  E-value: 1.97e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 343 IEASLEPS-RITGDPRRLAQVIRNVLDNADRHAASRISITLRNTGSGAQITIDNDGPPVPAADRERIFERFVRLDQSRSr 421
Cdd:cd16954   21 ISLDISPElRFPGERNDLMELLGNLLDNACKWCLEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLDEQRP- 99

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 500008990 422 esgGSGLGLAIAAGIMTAHHGWIRTGETLGGGCRFELGF 460
Cdd:cd16954  100 ---GQGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 346-455 1.02e-20

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 87.08  E-value: 1.02e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 346 SLEPSRITGDPRRLAQVIRNVLDNADRH--AASRISITLRNTgSGAQITIDNDGPPVPAADRERIFERFVRLDqsrSRES 423
Cdd:cd16940    1 SAADIQVQGDALLLFLLLRNLVDNAVRYspQGSRVEIKLSAD-DGAVIRVEDNGPGIDEEELEALFERFYRSD---GQNY 76

                         90       100       110
                 ....*....|....*....|....*....|..
gi 500008990 424 GGSGLGLAIAAGIMTAHHGWIRTGETLGGGCR 455
Cdd:cd16940   77 GGSGLGLSIVKRIVELHGGQIFLGNAQGGGLE 108
envZ PRK09467
osmolarity sensor protein; Provisional
 217-453 1.54e-18

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 87.66  E-value: 1.54e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 217 GRVDVPPT-----SDEIQALAETMNMMLGRLQASDQEQRRFVSDASHELRSPLATLSAGVEIAAADASgatweHMKTVLA 291
Cdd:PRK09467 192 GKGEIPPPlreygASEVRSVTRAFNQMAAGIKQLEDDRTLLMAGVSHDLRTPLTRIRLATEMMSEEDG-----YLAESIN 266

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 292 GETARMRYLVEDLLTLAKTndgGLRLETTDVDLDDVLNEeVRRLRSTSTRRIEASL--EPSRITGDPRRLAQVIRNVLDN 369
Cdd:PRK09467 267 KDIEECNAIIEQFIDYLRT---GQEMPMEMADLNALLGE-VIAAESGYEREIETALqpGPIEVPMNPIAIKRALANLVVN 342

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 370 ADRHAASRISITLRNTGSGAQITIDNDGPPVPAADRERIFERFVRLDQSRSreSGGSGLGLAIAAGIMTAHHGWIRTGET 449
Cdd:PRK09467 343 AARYGNGWIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARG--SSGTGLGLAIVKRIVDQHNGKVELGNS 420


                 ....
gi 500008990 450 LGGG 453
Cdd:PRK09467 421 EEGG 424
PRK09303 PRK09303
histidine kinase;
225-456 1.92e-18

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 86.93  E-value: 1.92e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 225 SDEIQALAETMNMMLGRLQASDQEQRRFVsdasHELRSPLATLSAGVE---IAAADASGATWEHMKTVLAGETAR----M 297
Cdd:PRK09303 131 SDELFVLRQENETLLEQLKFKDRVLAMLA----HDLRTPLTAASLALEtleLGQIDEDTELKPALIEQLQDQARRqleeI 206

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 298 RYLVEDLLTLAKTNDGGLRLETTDVDLDDVLNE---EVRRLRSTSTRRIEASLePS---RITGDPRRLAQVIRNVLDNAD 371
Cdd:PRK09303 207 ERLITDLLEVGRTRWEALRFNPQKLDLGSLCQEvilELEKRWLAKSLEIQTDI-PSdlpSVYADQERIRQVLLNLLDNAI 285

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 372 RH--AASRISIT-LRNTGSGAQITIDNDGPPVPAADRERIFERFVRLDQSRSREsgGSGLGLAIAAGIMTAHHGWIRTGE 448
Cdd:PRK09303 286 KYtpEGGTITLSmLHRTTQKVQVSICDTGPGIPEEEQERIFEDRVRLPRDEGTE--GYGIGLSVCRRIVRVHYGQIWVDS 363


                 ....*...
gi 500008990 449 TLGGGCRF 456
Cdd:PRK09303 364 EPGQGSCF 371
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 355-458 2.02e-18

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 80.61  E-value: 2.02e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 355 DPRRLAQVIRNVLDNADRHAAS--RISITLRNT-GSGAQITIDNDGPPVPAADRERIFERFVRLDQSRSRESGGSGLGLA 431
Cdd:cd16925    1 DAEKYERVVLNLLSNAFKFTPDggRIRCILEKFrLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLS 80

                         90       100
                 ....*....|....*....|....*..
gi 500008990 432 IAAGIMTAHHGWIRTGETLGGGCRFEL 458
Cdd:cd16925   81 IVKEFVELHGGTVTVSDAPGGGALFQV 107
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
241-458 1.46e-16

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 82.32  E-value: 1.46e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 241 RLQASDQEQRR------FVSDASHELRSPLATLSAGVEIAAADASGATWEHMKTVLAGETARMRYLVEDLLTLAKTNdgg 314
Cdd:PRK11360 376 RLQRRVARQERlaalgeLVAGVAHEIRNPLTAIRGYVQIWRQQTSDPPSQEYLSVVLREVDRLNKVIDQLLEFSRPR--- 452

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 315 lRLETTDVDLDDVLNEE---VRRLRSTSTRRIEASLEPS--RITGDPRRLAQVIRNVLDNADRHAASRISITLR--NTGS 387
Cdd:PRK11360 453 -ESQWQPVSLNALVEEVlqlFQTAGVQARVDFETELDNElpPIWADPELLKQVLLNILINAVQAISARGKIRIRtwQYSD 531

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 500008990 388 GAQ-ITIDNDGPPVPAADRERIFERFVrldqsrSRESGGSGLGLAIAAGIMTAHHGWIRTGETLGGGCRFEL 458
Cdd:PRK11360 532 GQVaVSIEDNGCGIDPELLKKIFDPFF------TTKAKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTL 597
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 359-463 1.50e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 72.62  E-value: 1.50e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 359 LAQVIRNVLDNADRHAASRISITLR--NTGSGAQITIDNDGPPVPAADRERIFERFVRLDQSRSRESGGSGLGLAIAAGI 436
Cdd:cd16952    1 LRSAFSNLVSNAVKYTPPSDTITVRwsQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHV 80

                         90       100
                 ....*....|....*....|....*..
gi 500008990 437 MTAHHGWIRTGETLGGGCRFELGFAPA 463
Cdd:cd16952   81 MSRHDARLLIASELGKGSRFTCLFPSS 107
PRK10815 PRK10815
two-component system sensor histidine kinase PhoQ;
361-461 1.85e-15

two-component system sensor histidine kinase PhoQ;


Pssm-ID: 182754 [Multi-domain]  Cd Length: 485  Bit Score: 78.52  E-value: 1.85e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 361 QVIRNVLDNADRHAASRISITLRNTGSGAQITIDNDGPPVPAADRERIFERFVRLDQSRSresgGSGLGLAIAAGIMTAH 440
Cdd:PRK10815 381 EVMGNVLDNACKYCLEFVEISARQTDEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRP----GQGLGLSVAREITEQY 456

                         90       100
                 ....*....|....*....|.
gi 500008990 441 HGWIRTGETLGGGCRFELGFA 461
Cdd:PRK10815 457 EGKISAGDSPLGGARMEVIFG 477
PRK10490 PRK10490
sensor protein KdpD; Provisional
 227-465 2.31e-15

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 78.92  E-value: 2.31e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 227 EIQALAETMNMM----LGRLQ----------ASDQEQRR--FVSDASHELRSPLATLSAGVEIAAADASGATWEHmktvl 290
Cdd:PRK10490 626 EQQRLLETFTLLianaLERLTltaseeqarlASEREQLRnaLLAALSHDLRTPLTVLFGQAEILTLDLASEGSPH----- 700

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 291 AGETARMRY-------LVEDLLTLAKTNDGGLRLETTDVDLDDVLNEEVRRLRST-STRRIEASLePSRIT---GDPRRL 359
Cdd:PRK10490 701 ARQASEIRQqvlnttrLVNNLLDMARIQSGGFNLRKEWLTLEEVVGSALQMLEPGlSGHPINLSL-PEPLTlihVDGPLF 779

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 360 AQVIRNVLDNADRHAASRISITLRNTGSGAQITID--NDGPPVPAADRERIFERFVRLDqsrsRESG--GSGLGLAIAAG 435
Cdd:PRK10490 780 ERVLINLLENAVKYAGAQAEIGIDAHVEGERLQLDvwDNGPGIPPGQEQLIFDKFARGN----KESAipGVGLGLAICRA 855

                        250       260       270
                 ....*....|....*....|....*....|..
gi 500008990 436 IMTAHHGWIRTGETLGGGC--RFELGFAPAPE 465
Cdd:PRK10490 856 IVEVHGGTIWAENRPEGGAcfRVTLPLETPPE 887
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 359-442 3.85e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 70.88  E-value: 3.85e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 359 LAQVIRNVLDNADRHAA--SRISITLRNTGSGAQITIDNDGPPVPAADRERIFERFVRLDQsrSRESGGSGLGLAIAAGI 436
Cdd:cd16923    1 LQRVFSNLLSNAIKYSPenTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDN--SRNTEGAGLGLSIAKAI 78


                 ....*.
gi 500008990 437 MTAHHG 442
Cdd:cd16923   79 IELHGG 84
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 359-453 1.80e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 66.32  E-value: 1.80e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 359 LAQVIRNVLDNADRHAASRISITLRNTGSGAQITIDNDGPPVPAADRERIFERFVRLDQSRSreSGGSGLGLAIAAGIMT 438
Cdd:cd16950    1 LKRVLSNLVDNALRYGGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARG--TSGTGLGLAIVQRISD 78

                         90
                 ....*....|....*
gi 500008990 439 AHHGWIRTGETLGGG 453
Cdd:cd16950   79 AHGGSLTLANRAGGG 93
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 343-458 2.19e-13

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 71.42  E-value: 2.19e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 343 IEASLEPSRITGDPRRLAQVIRNVLDNADRHAAS------RISITLRNTGSGAQITIDNDGPPVPAADRERIFERFVrld 416
Cdd:COG3290  266 IDIDSDLPDLPLSDTDLVTILGNLLDNAIEAVEKlpeeerRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGF--- 342

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 500008990 417 qsRSRESGGSGLGLAIAAGIMTAHHGWIRTGETLGGGCRFEL 458
Cdd:COG3290  343 --STKLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTV 382
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 359-458 5.03e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 65.21  E-value: 5.03e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 359 LAQVIRNVLDNA-----------------DRHAASRISITLRNTGSGaqitidndgppVPAADRERIFERFVRLDQSRSR 421
Cdd:cd16922    1 LRQILLNLLGNAikfteegevtlrvsleeEEEDGVQLRFSVEDTGIG-----------IPEEQQARLFEPFSQADSSTTR 69

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 500008990 422 ESGGSGLGLAIAAGIMTAHHGWIRTGETLGGGCRFEL 458
Cdd:cd16922   70 KYGGTGLGLAISKKLVELMGGDISVESEPGQGSTFTF 106
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 356-459 5.04e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 65.14  E-value: 5.04e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 356 PRRLAQVIRNVLDNADRHAASRISITLRNTGSGAQ--ITIDNDGPPVPAADRERIFERFVRldqsrSRESG-GSGLGLAI 432
Cdd:cd16943    1 PSQLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQvlIEVEDTGSGIDPEILGRIFDPFFT-----TKPVGeGTGLGLSL 75

                         90       100
                 ....*....|....*....|....*..
gi 500008990 433 AAGIMTAHHGWIRTGETLGGGCRFELG 459
Cdd:cd16943   76 SYRIIQKHGGTIRVASVPGGGTRFTII 102
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
257-470 1.50e-12

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 69.43  E-value: 1.50e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 257 SHELRSPLATLSAGVEIAAADASGATWEH-MKTVLAGETARMRYLVEDLLTLAKTNDggLRLETtdVDLDDVLNEEVR-R 334
Cdd:PRK10364 245 AHEIRNPLSSIKGLAKYFAERAPAGGEAHqLAQVMAKEADRLNRVVSELLELVKPTH--LALQA--VDLNDLINHSLQlV 320

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 335 LRSTSTRRIEASLEPS----RITGDPRRLAQVIRNVLDNA----DRHAasRISITLRNTGSGAQITIDNDGPPVPAADRE 406
Cdd:PRK10364 321 SQDANSREIQLRFTANdtlpEIQADPDRLTQVLLNLYLNAiqaiGQHG--VISVTASESGAGVKISVTDSGKGIAADQLE 398

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 500008990 407 RIFERFVrldqsrSRESGGSGLGLAIAAGIMTAHHGWIRTGETLGGGCRFELGFAPAPEPRQPK 470
Cdd:PRK10364 399 AIFTPYF------TTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVNITRRDPQ 456
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 227-479 1.50e-12

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 69.93  E-value: 1.50e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 227 EIQALAETMNMMLGRLQASDQEQRRFVSDASHELRSPL------ATLSAGVEIAAA-----------------------D 277
Cdd:PRK11466 422 ELQELVIEHRQARAEAEKASQAKSAFLAAMSHEIRTPLygilgtAQLLADNPALNAqrddlraitdsgeslltilndilD 501

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 278 ASGATWEHMKTVLAGETARMRYLVEDLLTLAKTndgglRLETTDVDLDDVLNEEVrrlrststrrieaslePSRITGDPR 357
Cdd:PRK11466 502 YSAIEAGGKNVSVSDEPFEPRPLLESTLQLMSG-----RVKGRPIRLATDIADDL----------------PTALMGDPR 560

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 358 RLAQVIRNVLDNADRHaASRISITLRNTGSGAQ--ITIDNDGPPVPAADRERIFERFVRLDQSRsresGGSGLGLAIAAG 435
Cdd:PRK11466 561 RIRQVITNLLSNALRF-TDEGSIVLRSRTDGEQwlVEVEDSGCGIDPAKLAEIFQPFVQVSGKR----GGTGLGLTISSR 635

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 500008990 436 IMTAHHGWIRTGETLGGGCRFELGF----APAPEPRQPKDPVTAGDPR 479
Cdd:PRK11466 636 LAQAMGGELSATSTPEVGSCFCLRLplrvATAPVPKTVNQAVRLDGLR 683
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
241-483 1.69e-11

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 66.62  E-value: 1.69e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 241 RLQASDQEQRR------FVSDASHELRSPLATLSAGVEIAAA--DASGATWEHMKTVLaGETARMRYLVEDLLTLAKTND 312
Cdd:PRK13837 436 ALERRLEHARRleavgtLASGIAHNFNNILGAILGYAEMALNklARHSRAARYIDEII-SAGARARLIIDQILAFGRKGE 514

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 313 GglrlETTDVDLDDVLNEEVRRLRSTSTRRIEASL----EPSRITGDPRRLAQVIRNVLDNADR--HAASRISITLRN-- 384
Cdd:PRK13837 515 R----NTKPFDLSELVTEIAPLLRVSLPPGVELDFdqdqEPAVVEGNPAELQQVLMNLCSNAAQamDGAGRVDISLSRak 590

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 385 -------------TGSGAQITIDNDGPPVPAADRERIFERFVrldqsrSRESGGSGLGLAIAAGIMTAHHGWIRTGETLG 451
Cdd:PRK13837 591 lrapkvlshgvlpPGRYVLLRVSDTGAGIDEAVLPHIFEPFF------TTRAGGTGLGLATVHGIVSAHAGYIDVQSTVG 664

                        250       260       270
                 ....*....|....*....|....*....|..
gi 500008990 452 GGCRFELGFapapePRQPKDPVTAGDPRAPDT 483
Cdd:PRK13837 665 RGTRFDVYL-----PPSSKVPVAPQAFFGPGP 691
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 359-458 2.67e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 59.99  E-value: 2.67e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 359 LAQVIRNVLDNA-DRHAAS-----RISITLRNTGSGAQITIDNDGPPVPAADRERIFERFVrldqsRSRESGGSGLGLAI 432
Cdd:cd16915    1 LITIVGNLIDNAlDALAATgapnkQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGV-----STKGQGERGIGLAL 75

                         90       100
                 ....*....|....*....|....*.
gi 500008990 433 AAGIMTAHHGWIRTGETLGGGCRFEL 458
Cdd:cd16915   76 VRQSVERLGGSITVESEPGGGTTFSI 101
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 359-442 1.11e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 58.74  E-value: 1.11e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 359 LAQVIRNVLDNADRHA---ASRISITLRNTGSGAQITIDNDGPPVPAADRERIFERFVRLDQSRSRESGGSGLGLAIAAG 435
Cdd:cd16953    1 LGQVLRNLIGNAISFSppdTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQHSGLGLSISRQ 80


                 ....*..
gi 500008990 436 IMTAHHG 442
Cdd:cd16953   81 IIEAHGG 87
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 355-453 2.52e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 57.47  E-value: 2.52e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 355 DPRRLAQVIRNVLDNADRH--AASRISITLRNTGSGAQITIDNDGPPVPAADRERIFERFVRLDQSRSRESgGSGLGLAI 432
Cdd:cd16945    1 DPFLLRQAINNLLDNAIDFspEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQK-STGLGLAF 79

                         90       100
                 ....*....|....*....|.
gi 500008990 433 AAGIMTAHHGWIRTGETLGGG 453
Cdd:cd16945   80 VQEVAQLHGGRITLRNRPDGV 100
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 359-456 4.23e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 56.95  E-value: 4.23e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 359 LAQVIRNVLDNA----DRHAASRISITLRNTGSGAQITIDNDGPPVPAADRERIFERFVRLDqSRSrESGGSGLGLAIAA 434
Cdd:cd16921    1 LGQVLTNLLGNAikfrRPRRPPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLH-SRE-EYEGTGVGLAIVR 78

                         90       100
                 ....*....|....*....|..
gi 500008990 435 GIMTAHHGWIRTGETLGGGCRF 456
Cdd:cd16921   79 KIIERHGGRIWLESEPGEGTTF 100
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 359-458 1.02e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 55.54  E-value: 1.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 359 LAQVIRNVLDNADRHAASRISITLRNTGSGAQITIDNDGPPVPAADRERIFERFVrldqsRSRESG-GSGLGLAIAAGIM 437
Cdd:cd16976    5 LMNLLQNALDAMGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFF-----TTKPVGkGTGLGLSISYGIV 79

                         90       100
                 ....*....|....*....|.
gi 500008990 438 TAHHGWIRTGETLGGGCRFEL 458
Cdd:cd16976   80 EEHGGRLSVANEEGAGARFTF 100
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 354-444 1.78e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 55.60  E-value: 1.78e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 354 GDPRRLAQVIRNVLDNADRHAASR--ISITLRNTGSGAQITIDNDGPPVPAADRERIFERFVRLDQSRSRESGGSGLGLA 431
Cdd:cd16947   16 ANTEALQRILKNLISNAIKYGSDGkfLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAKQGNGLGLT 95

                         90
                 ....*....|...
gi 500008990 432 IAAGIMTAHHGWI 444
Cdd:cd16947   96 ITKRLAESMGGSI 108
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 359-450 2.89e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 54.71  E-value: 2.89e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 359 LAQVIRNVLDNA-----DRHAASRIS------ITLRNTGS--GAQITIDNDGPPVPAADRERIFERFVRldqsrSREsGG 425
Cdd:cd16918    1 LIQVFLNLVRNAaqalaGSGGEIILRtrtqrqVTLGHPRHrlALRVSVIDNGPGIPPDLQDTIFYPMVS-----GRE-NG 74

                         90       100
                 ....*....|....*....|....*....
gi 500008990 426 SGLGLAIAAGIMTAHHGWI----RTGETL 450
Cdd:cd16918   75 TGLGLAIAQNIVSQHGGVIecdsQPGHTV 103
HisKA pfam00512
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...
 248-313 1.29e-08

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.


Pssm-ID: 459839 [Multi-domain]  Cd Length: 66  Bit Score: 51.44  E-value: 1.29e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 500008990  248 EQRRFVSDASHELRSPLATLSAGVEIAAADASGATWEHMKTVLAGETARMRYLVEDLLTLAKTNDG 313
Cdd:pfam00512   1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQREYLETILRSAERLLRLINDLLDLSRIEAG 66
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 359-456 3.36e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 51.24  E-value: 3.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 359 LAQVIRNVLDNA----DRHAASRISITLRNTGSGA---QITIDNDGPPVPAADRERIFERFVrldqsrSRESGGSGLGLA 431
Cdd:cd16920    1 IQQVLINLVRNGieamSEGGCERRELTIRTSPADDravTISVKDTGPGIAEEVAGQLFDPFY------TTKSEGLGMGLS 74

                         90       100
                 ....*....|....*....|....*
gi 500008990 432 IAAGIMTAHHGWIRTGETLGGGCRF 456
Cdd:cd16920   75 ICRSIIEAHGGRLSVESPAGGGATF 99
HisKA cd00082
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ...
 246-309 3.70e-08

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.


Pssm-ID: 119399 [Multi-domain]  Cd Length: 65  Bit Score: 49.90  E-value: 3.70e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 500008990 246 DQEQRRFVSDASHELRSPLATLSAGVEIAAADASG-ATWEHMKTVLAGETARMRYLVEDLLTLAK 309
Cdd:cd00082    1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDdEEQREYLERIREEAERLLRLINDLLDLSR 65
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
217-458 5.10e-08

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 55.90  E-value: 5.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990  217 GRVDVPPTSDEIQALAETMNMMLGRLQASDQeqrrFVSDASHELRSPLATLSAGVEIAAADASGATWEHMKTVLAGETAR 296
Cdd:PRK09959  684 GWQDITETRDLIHALEVERNKAINATVAKSQ----FLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEAISLAYATGQ 759

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990  297 -MRYLVEDLLTLAKTNDGGLRLETTDVDLDDVLNEEVRRLRSTSTRRIEA----SLEPSR--ITGDPRRLAQVIRNVLDN 369
Cdd:PRK09959  760 sLLGLIGEILDVDKIESGNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIAlscsSTFPDHylVKIDPQAFKQVLSNLLSN 839

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990  370 ADR---HAASRISITL---RNTGSGAQITIDNDGPPVPAADRERIFERFVRldQSRSRESGGSGLGLAIAAGIMTAHHGW 443
Cdd:PRK09959  840 ALKfttEGAVKITTSLghiDDNHAVIKMTIMDSGSGLSQEEQQQLFKRYSQ--TSAGRQQTGSGLGLMICKELIKNMQGD 917

                         250
                  ....*....|....*
gi 500008990  444 IRTGETLGGGCRFEL 458
Cdd:PRK09959  918 LSLESHPGIGTTFTI 932
HisKA smart00388
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...
 248-309 8.92e-08

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.


Pssm-ID: 214644 [Multi-domain]  Cd Length: 66  Bit Score: 49.10  E-value: 8.92e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 500008990   248 EQRRFVSDASHELRSPLATLSAGVEIAAADASGATWEHMKTVLAGETARMRYLVEDLLTLAK 309
Cdd:smart00388   1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQREYLETILREAERLLRLINDLLDLSR 62
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 232-460 1.01e-07

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 54.21  E-value: 1.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 232 AETMNMMlGRLQASdqeqrrfvsdASHELRSPLATLSAGVEIAAADASGATWEHMKTVLAgETARMRYLVEDLLTLAKTn 311
Cdd:COG5809  264 SEKLSVV-GELAAG----------IAHEIRNPLTSLKGFIQLLKDTIDEEQKTYLDIMLS-ELDRIESIISEFLVLAKP- 330

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 312 dGGLRLETtdVDLDDVLNEEVR-RLRSTSTRRIEASLEPSR----ITGDPRRLAQVIRNVLDNAdRHAASR---ISITLR 383
Cdd:COG5809  331 -QAIKYEP--KDLNTLIEEVIPlLQPQALLKNVQIELELEDdipdILGDENQLKQVFINLLKNA-IEAMPEggnITIETK 406

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 500008990 384 NT-GSGAQITIDNDGPPVPAADRERIFERFVrldqsrSRESGGSGLGLAIAAGIMTAHHGWIRTGETLGGGCRFELGF 460
Cdd:COG5809  407 AEdDDKVVISVTDEGCGIPEERLKKLGEPFY------TTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITL 478
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 247-432 1.74e-07

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 53.70  E-value: 1.74e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 247 QEQRR----FVSDASHELRSPLAtlsaGVeIaaadasGATWEHMKTVLAgeTARMRYL-------------VEDLLTLAK 309
Cdd:PRK11107 287 QEAARikseFLANMSHELRTPLN----GV-I------GFTRQTLKTPLT--PTQRDYLqtiersannllaiINDILDFSK 353

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 310 TNDGGLRLETTDVDLDDVLNEEVR-RLRSTSTRRIEASLE-----PSRITGDPRRLAQVIRNVLDNADR---HAASRISI 380
Cdd:PRK11107 354 LEAGKLVLENIPFSLRETLDEVVTlLAHSAHEKGLELTLNidpdvPDNVIGDPLRLQQIITNLVGNAIKfteSGNIDILV 433

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 500008990 381 TLRnTGSGAQIT----IDNDGPPVPAADRERIFERFVRLDQSRSRESGGSGLGLAI 432
Cdd:PRK11107 434 ELR-ALSNTKVQlevqIRDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVI 488
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
349-432 1.88e-07

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 53.82  E-value: 1.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 349 PSRITGDPRRLAQVIRNVLDNADR---------HAASR---ISITLRNTGSGaqitidndgppVPAADRERIFERFVRLD 416
Cdd:PRK10841 553 PVALNGDPMRLQQVISNLLSNAIKftdtgcivlHVRVDgdyLSFRVRDTGVG-----------IPAKEVVRLFDPFFQVG 621

                         90
                 ....*....|....*.
gi 500008990 417 QSRSRESGGSGLGLAI 432
Cdd:PRK10841 622 TGVQRNFQGTGLGLAI 637
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 225-460 2.04e-06

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 50.12  E-value: 2.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 225 SDEIQALAETMNMmLGRLQASdqeqrrfvsdASHELRSPLAT-------LSAGVEiaaadasgaTWEHMKTVLAGETARM 297
Cdd:COG5805  274 AEELMARSEKLSI-AGQLAAG----------IAHEIRNPLTSikgflqlLQPGIE---------DKEEYFDIMLSELDRI 333

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 298 RYLVEDLLTLAKTndggLRLETTDVDLDDVLNEEVR-RLRSTSTRRIEASLEPSR----ITGDPRRLAQVIRNVLDNADR 372
Cdd:COG5805  334 ESIISEFLALAKP----QAVNKEKENINELIQDVVTlLETEAILHNIQIRLELLDedpfIYCDENQIKQVFINLIKNAIE 409

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 373 HAAS--RISITLRNTGSGAQITIDNDGPPVPAADRERIFERFVRLDQSrsresgGSGLGLAIAAGIMTAHHGWIRTGETL 450
Cdd:COG5805  410 AMPNggTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPFFTTKEK------GTGLGLMVSYKIIENHNGTIDIDSKV 483

                        250
                 ....*....|
gi 500008990 451 GGGCRFELGF 460
Cdd:COG5805  484 GKGTTFTITL 493
PRK15347 PRK15347
two component system sensor kinase;
355-458 2.30e-06

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 50.41  E-value: 2.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 355 DPRRLAQVIRNVLDNADRHAAS-RISITLRNTGSGAQITIDNDGPPVPAADRERIFERFVRLDQSrsreSGGSGLGLAIA 433
Cdd:PRK15347 510 DSLRLRQILVNLLGNAVKFTETgGIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTH----SQGTGLGLTIA 585

                         90       100
                 ....*....|....*....|....*
gi 500008990 434 AGIMTAHHGWIRTGETLGGGCRFEL 458
Cdd:PRK15347 586 SSLAKMMGGELTLFSTPGVGSCFSL 610
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 355-453 4.04e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 45.53  E-value: 4.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 355 DPRRLAQVIRNVLDNADRHAASR--ISITLRNTGSGAQITIDNDGPPVPAADRERIFERFVRLDQSRsRESGGSGLGLAI 432
Cdd:cd16975    1 DTLLLSRALINIISNACQYAPEGgtVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSR-RSGGHYGMGLYI 79

                         90       100
                 ....*....|....*....|.
gi 500008990 433 AAGIMTAHHGWIRTGETLGGG 453
Cdd:cd16975   80 AKNLVEKHGGSLIIENSQKGG 100
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 257-453 1.88e-05

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 47.37  E-value: 1.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 257 SHELRSPLATLSA---GVEIAAADASGATWEHMKTVLAGETARMRYLVEDLLTLAKTNDGGLRLettdVDLDDVLN---E 330
Cdd:COG4192  441 AHELNQPLNAMSMylfSAKKALEQENYAQLPTSLDKIEGLIERMDKIIKSLRQFSRKSDTPLQP----VDLRQVIEqawE 516

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 331 EVRRLRSTSTRRIEASLEPsRITGDPRRLAQVIRNVLDNA--DRHAASRISITLRNTGSGAQITIDNDGPPVPAADRerI 408
Cdd:COG4192  517 LVESRAKPQQITLHIPDDL-MVQGDQVLLEQVLVNLLVNAldAVATQPQISVDLLSNAENLRVAISDNGNGWPLVDK--L 593

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 500008990 409 FERFVrldqsrSRESGGSGLGLAIAAGIMTAHHGWIRTGETLGGG 453
Cdd:COG4192  594 FTPFT------TTKEVGLGLGLSICRSIMQQFGGDLYLASTLERG 632
glnL PRK11073
nitrogen regulation protein NR(II);
243-444 3.13e-05

nitrogen regulation protein NR(II);


Pssm-ID: 182947 [Multi-domain]  Cd Length: 348  Bit Score: 45.84  E-value: 3.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 243 QASDQEQRRFVSDASHELRSPLATLSAGVEI-AAADASGATWEHMKTVLagETA-RMRYLVEDLLTLAKTndgGLRLETT 320
Cdd:PRK11073 124 HAQQVAARDLVRGLAHEIKNPLGGLRGAAQLlSKALPDPALTEYTKVII--EQAdRLRNLVDRLLGPQRP---GTHVTES 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 321 dvdLDDVLnEEVR---RLRSTSTRRIEASLEPS--RITGDPRRLAQVIRNVLDNADRHAASRI-SITLRN------TGSG 388
Cdd:PRK11073 199 ---IHKVA-ERVVqlvSLELPDNVRLIRDYDPSlpELAHDPDQIEQVLLNIVRNALQALGPEGgTITLRTrtafqlTLHG 274

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 500008990 389 ------AQITIDNDGPPVPAADRERIFERFVrldqsrSRESGGSGLGLAIAAGIMTAHHGWI 444
Cdd:PRK11073 275 eryrlaARIDIEDNGPGIPPHLQDTLFYPMV------SGREGGTGLGLSIARNLIDQHSGKI 330
HAMP smart00304
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
195-245 5.42e-05

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;


Pssm-ID: 197640 [Multi-domain]  Cd Length: 53  Bit Score: 40.69  E-value: 5.42e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 500008990   195 RSLRQVERIRGQVAGISARNLDGRVDVPpTSDEIQALAETMNMMLGRLQAS 245
Cdd:smart00304   2 RLLRPLRRLAEAAQRIADGDLTVRLPVD-GRDEIGELARAFNEMADRLEET 51
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 355-460 8.21e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 41.75  E-value: 8.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 355 DPRRLAQVIRNVLDNADRHAASR----ISITLR---NTGSGAQITIDNDGPPVPAADRERIFERFVrldqsrSRESGGSG 427
Cdd:cd16944    1 DTTQISQVLTNILKNAAEAIEGRpsdvGEVRIRveaDQDGRIVLIVCDNGKGFPREMRHRATEPYV------TTRPKGTG 74

                         90       100       110
                 ....*....|....*....|....*....|...
gi 500008990 428 LGLAIAAGIMTAHHGWIRTGETLGGGCRFELGF 460
Cdd:cd16944   75 LGLAIVKKIMEEHGGRISLSNREAGGACIRIIL 107
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
343-458 1.77e-04

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 43.85  E-value: 1.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 343 IEASLEPSRItgdPRRLAQVIrnvLDNADRHAAS------RISITLRNTGSGAQITIDNDGPPVPAADRERIFERFvrld 416
Cdd:COG2972  327 IDEELLDLLI---PKLILQPL---VENAIEHGIEpkegggTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL---- 396

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 500008990 417 qsrSRESGGSGLGLAIAAGIMTAHHG---WIRTGETLGGGCRFEL 458
Cdd:COG2972  397 ---SSKGEGRGIGLRNVRERLKLYYGeeyGLEIESEPGEGTTVTI 438
HAMP cd06225
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ...
 197-242 8.69e-04

Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.


Pssm-ID: 381743 [Multi-domain]  Cd Length: 45  Bit Score: 37.04  E-value: 8.69e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 500008990 197 LRQVERIRGQVAGISARNLDGRVDVPpTSDEIQALAETMNMMLGRL 242
Cdd:cd06225    1 TRPLRRLTEAARRIAEGDLDVRVPVR-SKDEIGELARAFNQMAERL 45
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
320-458 8.97e-04

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 41.14  E-value: 8.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 320 TDVDLDDVLNEEVRRLRSTSTRRIEASLEPSRITGDPRRLAQVIRNV---LDNADRHA-ASRISITLRNTGSGAQITIDN 395
Cdd:COG4585  121 DDLGLAAALEELAERLLRAAGIRVELDVDGDPDRLPPEVELALYRIVqeaLTNALKHAgATRVTVTLEVDDGELTLTVRD 200

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 500008990 396 DGPPVPAADReriferfvrldqsrsresGGSGLGLAIAAGIMTAHHGWIRTGETLGGGCRFEL 458
Cdd:COG4585  201 DGVGFDPEAA------------------PGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRA 245
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 242-465 9.17e-04

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 41.85  E-value: 9.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 242 LQASDQEQRRFVSDASHELRSPL---ATLSAgvEIAAADASGATWEHMKTV-LAGETarMRYLVEDLLTLAKTNDGGLRL 317
Cdd:PRK11091 276 LEKASRDKTTFISTISHELRTPLngiVGLSR--ILLDTELTAEQRKYLKTIhVSAIT--LGNIFNDIIDMDKMERRKLQL 351

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 318 ETTDVDLDDVLNE-EVRRLRSTSTRRIEASLE-----PSRITGDPRRLAQVIRNVLDNA-------------DRHAASRI 378
Cdd:PRK11091 352 DNQPIDFTDFLADlENLSGLQAEQKGLRFDLEpllplPHKVITDGTRLRQILWNLISNAvkftqqggvtvrvRYEEGDML 431

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 379 SITLRNTGSGaqitidndgppVPAADRERIFERFVRL-DQSRSRESGGSGLGLAIAAGIMTAHHGWIRTGETLGGGCRFE 457
Cdd:PRK11091 432 TFEVEDSGIG-----------IPEDELDKIFAMYYQVkDSHGGKPATGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFT 500


                 ....*....
gi 500008990 458 LGF-APAPE 465
Cdd:PRK11091 501 LTIhAPAVA 509
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
48-279 1.11e-03

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 41.54  E-value: 1.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990  48 LVASTETAARRQAADVIAQISGQDVAEAGQYIVSTAHTGQYVQILTPGGAVFAASVPAAKTVALTSLRPGHGQTLTQDVS 127
Cdd:COG0840   57 LLLLLALALLLVLLALLLLLALVVLLALLLALLLLLLALLALALAALALLAALAALLALLELLLAALLAALAIALLALAA 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 128 GLPSLRDDDDFLIIATGADVGGRLYTVVVAATVQVQADTVSTVAWFILGATPLLLVVVGVSVWVLVGRSL-RQVERIRGQ 206
Cdd:COG0840  137 LLALAALALALLALALLAAAAAAAAALAALLEAAALALAAAALALALLAAALLALVALAIILALLLSRSItRPLRELLEV 216

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 500008990 207 VAGISARNLDGRVDVpPTSDEIQALAETMNMMLGRLQASDQEQRRF---VSDASHELRSPLATLSAGVEIAAADAS 279
Cdd:COG0840  217 LERIAEGDLTVRIDV-DSKDEIGQLADAFNRMIENLRELVGQVRESaeqVASASEELAASAEELAAGAEEQAASLE 291
HAMP pfam00672
HAMP domain;
194-244 1.34e-03

HAMP domain;


Pssm-ID: 459898 [Multi-domain]  Cd Length: 53  Bit Score: 36.83  E-value: 1.34e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 500008990  194 GRSLRQVERIRGQVAGISARNLDGRVDVPpTSDEIQALAETMNMMLGRLQA 244
Cdd:pfam00672   4 RRILRPLRRLAEAARRIASGDLDVRLPVS-GRDEIGELARAFNQMAERLRE 53
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 359-432 1.95e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 37.15  E-value: 1.95e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 500008990 359 LAQVIRNVLDNADRHA-ASRISITLRNTGSGAQITIDNDGPPVPAADREriferfvrldqsrsresGGSGLGLAI 432
Cdd:cd16917    1 LYRIVQEALTNALKHAgASRVRVTLSYTADELTLTVVDDGVGFDGPAPP-----------------GGGGFGLLG 58
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 355-461 5.18e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 36.49  E-value: 5.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500008990 355 DPRRLAQVIRNVLDNADRHAA--SRISITLRNTGSGAQITIDNDGPPVPAADRERIFER-FVRLDQSRSRESggSGLGLA 431
Cdd:cd16948    2 DAKWLSFIIGQIVSNALKYSKqgGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKgFTGENGRNFQES--TGMGLY 79

                         90       100       110
                 ....*....|....*....|....*....|
gi 500008990 432 IAAGIMTAHHGWIRTGETLGGGCRFELGFA 461
Cdd:cd16948   80 LVKKLCDKLGHKIDVESEVGEGTTFTITFP 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH