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Conserved domains on  [gi|499991323|ref|WP_011672041|]
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transglycosylase domain-containing protein [Leptospira borgpetersenii]

Protein Classification

PBP1A family penicillin-binding protein( domain architecture ID 1001109)

PBP1A family penicillin-binding protein similar to Rickettsia conorii penicillin-binding protein 1A, a bifunctional transpeptidases/transglycosylase that catalyzes synthesis of cross-linked peptidoglycan from the lipid intermediates in cell wall formation

CATH:  1.10.3810.10
Gene Ontology:  GO:0016740|GO:0009252|GO:0008360
PubMed:  18266856|33611146

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
MrcA super family cl34862
Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];
191-912 0e+00

Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG5009:

Pssm-ID: 444033 [Multi-domain]  Cd Length: 785  Bit Score: 563.24  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 191 LLSAGVIISLLLVGMILFWVGVITRE----SELKEmislfYN-HQPSVIYDRDGKKVSEIFAKKTSNLEWDAYPENLKKI 265
Cdd:COG5009    7 LLILLLLLLLLGALAVAGLYLYLSPDlpdvETLKD-----YQpPTPSRVYSADGKLIAEFGEERRIPVPIEEIPPLLINA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 266 VLLVEDRKFFSHSGINYMSVLRAAFVNIASFRFKQGASTITQQLARILLDDREKSLVRKIKEAQLAFALEYTYEKKQILL 345
Cdd:COG5009   82 FLAAEDKRFYEHPGVDPIGIARAAVVNLRTGRRVQGGSTITQQVAKNFLLSPERTLTRKIKEAILALRIEQELSKDEILE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 346 YYLNNVYLGHGAFGFASAAEFYFRKTPSELNTEEMIVLASLASAPNRFSPLKNPDLSRQRVNAIVhsfqkQEILKENpkp 425
Cdd:COG5009  162 LYLNKIYLGHRAYGVAAAAQTYFGKSLDELTLAEAAMLAGLPKAPSRYNPIRNPERALERRNYVL-----GRMLELG--- 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 426 KLDEI--------YLAFHMRSPGETVfgnrkdDSPYVTEHVRKFLNSLYPDSNIYeTGGFSIHTTIAEPVQAELSKIVKN 497
Cdd:COG5009  234 YITQAeyeaakaePLTARYHGASAEV------DAPYFAEMVRRELVERYGEDALY-TGGLKVYTTLDPRLQEAAEKALRD 306

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 498 YLDNIQKS----GLVRKTKLTDNK--------------------NSSETAVFRKYVQDISPALEL--------FIDTDSF 545
Cdd:COG5009  307 GLLAYDRRhgyrGPEAHLDLAEEDwdealaevpdvgdlrpavvlEVDDKSARVGLRDGETGTLPLeglkwarpYINDNRR 386

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 546 GGKSESG---------------------------LQVALVAVDPATGEILLMHGGSEFkADNQLDRTTAMKRQTGSSIKP 598
Cdd:COG5009  387 GPAPKSAsdvlkpgdvirvrpvadggwrlrqipeVQGALVALDPHTGAVLALVGGFDF-EQSKFNRATQAKRQPGSSFKP 465

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 599 ILYSAAIETElISASSRILDAPLIYRNQTGN--WMPENIGNQYDGDISVRHALAKSKNTAAVQIAEKLGISKIQDFFQKY 676
Cdd:COG5009  466 FVYAAALDNG-YTPATIINDAPIVFDDGGGGgvWRPKNYSGKFYGPTTLREALEKSRNLVTVRLLQDVGIDYVIDYAERF 544

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 677 FFPDPkvlqsrFRGDLSLALGSLEISPLEMALAYSAFANDGTIKRPYLIQKITDRSGKIVYERK-------------STD 743
Cdd:COG5009  545 GIYSK------LPPNLSLALGSGEVTPLEMARAYAVFANGGYRVEPYLIDRIEDRNGKVIYRADparacedcdaaewDGA 618

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 744 EFGLKVPEERkVLSSQVAEIMIDLLHGSANsagvRSTGYR-----GEVAGKTGTTNDNRDNWFVGVKPGMSMAIWLGYDD 818
Cdd:COG5009  619 EPRLPDPAEQ-VIDPRTAYQMTSMLRGVVQ----RGTGRRaralgRDIAGKTGTTNDSKDAWFVGFTPDLVAGVWVGFDD 693

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 819 PSyGLGSSALGGTVAAPLWGSVAKtfEATED-EKRKYPVTEHAISITVCEESGKLPGPSCKHPRKELFKNGTVPSEICPL 897
Cdd:COG5009  694 PR-SLGRGETGGRAALPIWIDFMK--AALKDkPEKPFPVPEGIVTVRIDPKTGLLASPGDPDAIFEAFKPGTEPTESASE 770

                        810
                 ....*....|....*
gi 499991323 898 NHGTDVKREVLRNVF 912
Cdd:COG5009  771 DLGPDASEGTGEGLF 785
 
Name Accession Description Interval E-value
MrcA COG5009
Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];
191-912 0e+00

Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 444033 [Multi-domain]  Cd Length: 785  Bit Score: 563.24  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 191 LLSAGVIISLLLVGMILFWVGVITRE----SELKEmislfYN-HQPSVIYDRDGKKVSEIFAKKTSNLEWDAYPENLKKI 265
Cdd:COG5009    7 LLILLLLLLLLGALAVAGLYLYLSPDlpdvETLKD-----YQpPTPSRVYSADGKLIAEFGEERRIPVPIEEIPPLLINA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 266 VLLVEDRKFFSHSGINYMSVLRAAFVNIASFRFKQGASTITQQLARILLDDREKSLVRKIKEAQLAFALEYTYEKKQILL 345
Cdd:COG5009   82 FLAAEDKRFYEHPGVDPIGIARAAVVNLRTGRRVQGGSTITQQVAKNFLLSPERTLTRKIKEAILALRIEQELSKDEILE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 346 YYLNNVYLGHGAFGFASAAEFYFRKTPSELNTEEMIVLASLASAPNRFSPLKNPDLSRQRVNAIVhsfqkQEILKENpkp 425
Cdd:COG5009  162 LYLNKIYLGHRAYGVAAAAQTYFGKSLDELTLAEAAMLAGLPKAPSRYNPIRNPERALERRNYVL-----GRMLELG--- 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 426 KLDEI--------YLAFHMRSPGETVfgnrkdDSPYVTEHVRKFLNSLYPDSNIYeTGGFSIHTTIAEPVQAELSKIVKN 497
Cdd:COG5009  234 YITQAeyeaakaePLTARYHGASAEV------DAPYFAEMVRRELVERYGEDALY-TGGLKVYTTLDPRLQEAAEKALRD 306

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 498 YLDNIQKS----GLVRKTKLTDNK--------------------NSSETAVFRKYVQDISPALEL--------FIDTDSF 545
Cdd:COG5009  307 GLLAYDRRhgyrGPEAHLDLAEEDwdealaevpdvgdlrpavvlEVDDKSARVGLRDGETGTLPLeglkwarpYINDNRR 386

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 546 GGKSESG---------------------------LQVALVAVDPATGEILLMHGGSEFkADNQLDRTTAMKRQTGSSIKP 598
Cdd:COG5009  387 GPAPKSAsdvlkpgdvirvrpvadggwrlrqipeVQGALVALDPHTGAVLALVGGFDF-EQSKFNRATQAKRQPGSSFKP 465

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 599 ILYSAAIETElISASSRILDAPLIYRNQTGN--WMPENIGNQYDGDISVRHALAKSKNTAAVQIAEKLGISKIQDFFQKY 676
Cdd:COG5009  466 FVYAAALDNG-YTPATIINDAPIVFDDGGGGgvWRPKNYSGKFYGPTTLREALEKSRNLVTVRLLQDVGIDYVIDYAERF 544

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 677 FFPDPkvlqsrFRGDLSLALGSLEISPLEMALAYSAFANDGTIKRPYLIQKITDRSGKIVYERK-------------STD 743
Cdd:COG5009  545 GIYSK------LPPNLSLALGSGEVTPLEMARAYAVFANGGYRVEPYLIDRIEDRNGKVIYRADparacedcdaaewDGA 618

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 744 EFGLKVPEERkVLSSQVAEIMIDLLHGSANsagvRSTGYR-----GEVAGKTGTTNDNRDNWFVGVKPGMSMAIWLGYDD 818
Cdd:COG5009  619 EPRLPDPAEQ-VIDPRTAYQMTSMLRGVVQ----RGTGRRaralgRDIAGKTGTTNDSKDAWFVGFTPDLVAGVWVGFDD 693

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 819 PSyGLGSSALGGTVAAPLWGSVAKtfEATED-EKRKYPVTEHAISITVCEESGKLPGPSCKHPRKELFKNGTVPSEICPL 897
Cdd:COG5009  694 PR-SLGRGETGGRAALPIWIDFMK--AALKDkPEKPFPVPEGIVTVRIDPKTGLLASPGDPDAIFEAFKPGTEPTESASE 770

                        810
                 ....*....|....*
gi 499991323 898 NHGTDVKREVLRNVF 912
Cdd:COG5009  771 DLGPDASEGTGEGLF 785
PBP_1a_fam TIGR02074
penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan ...
 256-849 3.56e-163

penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273955 [Multi-domain]  Cd Length: 531  Bit Score: 487.15  E-value: 3.56e-163
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323  256 DAYPENLKKIVLLVEDRKFFSHSGINYMSVLRAAFVNIASFRFKQGASTITQQLARILLDDREKSLVRKIKEAQLAFALE 335
Cdd:TIGR02074   8 DDIPENLINAFLAIEDRRFYDHFGIDLKGIGRAAVANITSGRVLEGGSTITQQLAKNLYLTNERTITRKIQEALLALKLE 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323  336 YTYEKKQILLYYLNNVYLGHGAFGFASAAEFYFRKTPSELNTEEMIVLASLASAPNRFSPLKNPDLSRQRVNAIVHSFQK 415
Cdd:TIGR02074  88 QKLSKDEILELYLNRIYFGNGAYGIEAAAQFYFGKSVNDLTLAEAAMLAGLPKAPSAYNPFKNPERAKDRRNLVLSNMVE 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323  416 QEILKENPKPKLDEIYLAFHMRSPGEtvfgnRKDDSPYVTEHVRKFLNSLYPDsNIYeTGGFSIHTTIAEPVQAELSKIV 495
Cdd:TIGR02074 168 NGYITAEEAEEAINEPIQLYLQTKKS-----EQYKAPYFVDYVIQELEEEYGE-ELY-TGGLKIYTTLDLDAQKAAEKVL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323  496 KNYLDNiqksglvrktkltdnknssetavfrkyvqdispalelfidtdsFGGKSESGLQVALVAVDPATGEILLMHGGSE 575
Cdd:TIGR02074 241 NTGLRV-------------------------------------------AGRRDGDDLQAALVAIDPDTGAVRALVGGRD 277

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323  576 FKaDNQLDRTTAMKRQTGSSIKPILYSAAIETeLISASSRILDAPLIYrNQTGNWMPENIGNQYDGDISVRHALAKSKNT 655
Cdd:TIGR02074 278 YG-KSQFNRATQAKRQPGSTFKPFVYAAALEK-GLTPATIVNDEPITY-NGNGPWSPKNYGGGYRGNVTLRQALAQSRNI 354

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323  656 AAVQIAEKLGISKIQDFFQKYFFPDPKVLqsrfrgDLSLALGSLEISPLEMALAYSAFANDGTIKRPYLIQKITDRSGKI 735
Cdd:TIGR02074 355 PAVRLLQEVGLDKVVALAKRFGITSPLDP------VLSLALGTVEVSPLEMASAYAVFANGGKYVEPHGIRKIVDRDGKV 428

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323  736 VYERKstdefglkvPEERKVLSSQVAEIMIDLL-----HGSANSAgvRSTGYrgEVAGKTGTTNDNRDNWFVGVKPGMSM 810
Cdd:TIGR02074 429 IYENK---------PKTTQVISPATAYIMTDMLkgvveSGTGRSA--RLPGR--PVAGKTGTTQNWRDAWFVGYTPYYVT 495

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|
gi 499991323  811 AIWLGYDDP-SYGLGSSalGGTVAAPLWGSVAKtfEATED 849
Cdd:TIGR02074 496 AVWVGYDDKkTLGKSGT--GGGLAAPIWRDFMA--EALKN 531
mrcA PRK11636
penicillin-binding protein 1a; Provisional
 231-893 1.46e-88

penicillin-binding protein 1a; Provisional


Pssm-ID: 183248 [Multi-domain]  Cd Length: 850  Bit Score: 300.89  E-value: 1.46e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 231 PSVIYDRDGKKVSEIFAKKTSNLEWDAYPENLKKIVLLVEDRKFFSHSGINYMSVLRAAFVNIASFRFKQGASTITQQLA 310
Cdd:PRK11636  47 PMQVYSADGELIAQYGEKRRIPLTLDQIPPEMVKAFIATEDSRFYEHHGVDPVGIFRAASVALFSGHASQGASTITQQLA 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 311 RILLDDREKSLVRKIKEAQLAFALEYTYEKKQILLYYLNNVYLGHGAFGFASAAEFYFRKTPSELNTEEMIVLASLASAP 390
Cdd:PRK11636 127 RNFFLSPERTLMRKIKEAFLAIRIEQLLTKDEILELYLNKIYLGYRAYGVGAAAQVYFGKTVDQLTLSEMAVIAGLPKAP 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 391 NRFSPLKNPDLSRQRVNAIV-----HSFQKQEILKENPKPKLDEIYLAfhmrsPgETVFGnrkddSPYVTEHVRKFLNSL 465
Cdd:PRK11636 207 STFNPLYSMDRAVARRNVVLsrmldEGYITQAQYDQARSEPIVANYHA-----P-EIAFS-----APYLSEMVRQEMYNR 275

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 466 YPDsNIYeTGGFSIHTTIAEPVQAELSKIVKN----Y-----------------------------LDNIQKSGLVRKTK 512
Cdd:PRK11636 276 YGE-NAY-EDGYRVYTTITRKVQQAAQQAVRNnvldYdmrhgyrgpanvlwkvgesawdnkkitdtLKALPTYGPLLPAV 353

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 513 LTDNKNSSETAVFRKyvqdiSPALELFID---------TDSFGGKS--------ESGLQV-------------------A 556
Cdd:PRK11636 354 VTSANPQEATAMLAD-----GSSVALPMEgvrwarpyrSDTQQGPTprkvtdvvQTGQQIwvrqvddawwlaqvpdvnsA 428

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 557 LVAVDPATGEILLMHGGSEFkadNQ--LDRTTAMKRQTGSSIKPILYSAAIETELISASsrIL-DAPlIYRNQTG---NW 630
Cdd:PRK11636 429 LVSINPQNGAVMALVGGFDF---NQskFNRATQALRQVGSNIKPFLYTAAMDKGLTLAS--MLnDVP-ISRWDAGagsDW 502

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 631 MPENIGNQYDGDISVRHALAKSKNTAAVQIAEKLGISKIQDFFQKYFFPDPKVLQSRfrgdlSLALGSLEISPLEMALAY 710
Cdd:PRK11636 503 RPKNSPPQYAGPIRLRQGLGQSKNVVMVRAMRAMGVDYAAEYLQRFGFPAQNIVHTE-----SLALGSASFTPMQVARGY 577

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 711 SAFANDGTIKRPYLIQKITDRSGKIVYERK---STDEFGLKV--------------------------------PEERKV 755
Cdd:PRK11636 578 AVMANGGFLVDPYFISKIENDQGGVIFEAKpkvACPECDIPViygdtqksnvlenddvenvatsqeqqnssvpmPQLEQA 657

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 756 LSSQVAEI--------MID-----LLHGSANS-----AGVRSTGYRG-------EVAGKTGTTNDNRDNWFVGVKPGMSM 810
Cdd:PRK11636 658 NQALVAQNgaqeyaphVINtplafLIKSALNTnifgePGWMGTGWRAgrdlkrrDIGGKTGTTNSSKDAWFSGYGPGVVT 737

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 811 AIWLGYDDPSYGLGSSALGGTV-------------AAPLWGSVAKTFEATEDEKRKYPvTEHAISITVCEESGKLP--GP 875
Cdd:PRK11636 738 SVWIGFDDHRRDLGRTTASGAIkdqisgyeggaksAQPAWDDYMKAALEGVPEQPLTP-PPGIVTVNIDRSTGKLAngGN 816

                        810
                 ....*....|....*...
gi 499991323 876 SckhpRKELFKNGTVPSE 893
Cdd:PRK11636 817 S----REEYFIEGTQPTQ 830
Transgly pfam00912
Transglycosylase; The penicillin-binding proteins are bifunctional proteins consisting of ...
 238-409 7.34e-70

Transglycosylase; The penicillin-binding proteins are bifunctional proteins consisting of transglycosylase and transpeptidase in the N- and C-terminus respectively. The transglycosylase domain catalyzes the polymerization of murein glycan chains.


Pssm-ID: 459993 [Multi-domain]  Cd Length: 177  Bit Score: 228.95  E-value: 7.34e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323  238 DGKKVSEIFAKKTSNLEWDAYPENLKKIVLLVEDRKFFSHSGINYMSVLRAAFVNIASFRFKQGASTITQQLARILLDDR 317
Cdd:pfam00912   1 DGTLLAELGEENREYVPLDDIPPALKNAVLAIEDRRFYEHGGVDPKGIARALLSNLRSGRIVQGGSTITQQLAKNLFLTP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323  318 EKSLVRKIKEAQLAFALEYTYEKKQILLYYLNNVYLGHGAFGFASAAEFYFRKTPSELNTEEMIVLASLASAPNRFSPLK 397
Cdd:pfam00912  81 ERTLTRKLKEAVLALKLERRYSKDEILEAYLNTVYFGRGAYGIEAAARAYFGKDASDLTLAEAALLAGLPQAPSRYNPLR 160

                         170
                  ....*....|..
gi 499991323  398 NPDLSRQRVNAI 409
Cdd:pfam00912 161 NPERAKRRRNLV 172
 
Name Accession Description Interval E-value
MrcA COG5009
Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];
191-912 0e+00

Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 444033 [Multi-domain]  Cd Length: 785  Bit Score: 563.24  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 191 LLSAGVIISLLLVGMILFWVGVITRE----SELKEmislfYN-HQPSVIYDRDGKKVSEIFAKKTSNLEWDAYPENLKKI 265
Cdd:COG5009    7 LLILLLLLLLLGALAVAGLYLYLSPDlpdvETLKD-----YQpPTPSRVYSADGKLIAEFGEERRIPVPIEEIPPLLINA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 266 VLLVEDRKFFSHSGINYMSVLRAAFVNIASFRFKQGASTITQQLARILLDDREKSLVRKIKEAQLAFALEYTYEKKQILL 345
Cdd:COG5009   82 FLAAEDKRFYEHPGVDPIGIARAAVVNLRTGRRVQGGSTITQQVAKNFLLSPERTLTRKIKEAILALRIEQELSKDEILE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 346 YYLNNVYLGHGAFGFASAAEFYFRKTPSELNTEEMIVLASLASAPNRFSPLKNPDLSRQRVNAIVhsfqkQEILKENpkp 425
Cdd:COG5009  162 LYLNKIYLGHRAYGVAAAAQTYFGKSLDELTLAEAAMLAGLPKAPSRYNPIRNPERALERRNYVL-----GRMLELG--- 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 426 KLDEI--------YLAFHMRSPGETVfgnrkdDSPYVTEHVRKFLNSLYPDSNIYeTGGFSIHTTIAEPVQAELSKIVKN 497
Cdd:COG5009  234 YITQAeyeaakaePLTARYHGASAEV------DAPYFAEMVRRELVERYGEDALY-TGGLKVYTTLDPRLQEAAEKALRD 306

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 498 YLDNIQKS----GLVRKTKLTDNK--------------------NSSETAVFRKYVQDISPALEL--------FIDTDSF 545
Cdd:COG5009  307 GLLAYDRRhgyrGPEAHLDLAEEDwdealaevpdvgdlrpavvlEVDDKSARVGLRDGETGTLPLeglkwarpYINDNRR 386

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 546 GGKSESG---------------------------LQVALVAVDPATGEILLMHGGSEFkADNQLDRTTAMKRQTGSSIKP 598
Cdd:COG5009  387 GPAPKSAsdvlkpgdvirvrpvadggwrlrqipeVQGALVALDPHTGAVLALVGGFDF-EQSKFNRATQAKRQPGSSFKP 465

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 599 ILYSAAIETElISASSRILDAPLIYRNQTGN--WMPENIGNQYDGDISVRHALAKSKNTAAVQIAEKLGISKIQDFFQKY 676
Cdd:COG5009  466 FVYAAALDNG-YTPATIINDAPIVFDDGGGGgvWRPKNYSGKFYGPTTLREALEKSRNLVTVRLLQDVGIDYVIDYAERF 544

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 677 FFPDPkvlqsrFRGDLSLALGSLEISPLEMALAYSAFANDGTIKRPYLIQKITDRSGKIVYERK-------------STD 743
Cdd:COG5009  545 GIYSK------LPPNLSLALGSGEVTPLEMARAYAVFANGGYRVEPYLIDRIEDRNGKVIYRADparacedcdaaewDGA 618

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 744 EFGLKVPEERkVLSSQVAEIMIDLLHGSANsagvRSTGYR-----GEVAGKTGTTNDNRDNWFVGVKPGMSMAIWLGYDD 818
Cdd:COG5009  619 EPRLPDPAEQ-VIDPRTAYQMTSMLRGVVQ----RGTGRRaralgRDIAGKTGTTNDSKDAWFVGFTPDLVAGVWVGFDD 693

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 819 PSyGLGSSALGGTVAAPLWGSVAKtfEATED-EKRKYPVTEHAISITVCEESGKLPGPSCKHPRKELFKNGTVPSEICPL 897
Cdd:COG5009  694 PR-SLGRGETGGRAALPIWIDFMK--AALKDkPEKPFPVPEGIVTVRIDPKTGLLASPGDPDAIFEAFKPGTEPTESASE 770

                        810
                 ....*....|....*
gi 499991323 898 NHGTDVKREVLRNVF 912
Cdd:COG5009  771 DLGPDASEGTGEGLF 785
MrcB COG0744
Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall ...
 182-877 1.16e-179

Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440507 [Multi-domain]  Cd Length: 630  Bit Score: 533.34  E-value: 1.16e-179
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 182 RRFQLPNVVLLSAGVIISLLLVGMILFWVGVITRESELKEMISLFYNHQPSVIYDRDGKKVSEIFAKKTSNLEWDAYPEN 261
Cdd:COG0744    6 RGKRLLRRLLGLLLLLLAVLVLAALAGLVALYVADLPDPEELEDLALPQTSTIYDRDGTLIATLGDENREWVPLDQIPPH 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 262 LKKIVLLVEDRKFFSHSGINYMSVLRAAFVNIASFRFKQGASTITQQLARILLDDREKSLVRKIKEAQLAFALEYTYEKK 341
Cdd:COG0744   86 LKDAVVAIEDRRFYEHGGVDPKGIARALVANLTAGGVVQGGSTITQQLVKNLFLSNERTLSRKLKEALLALKLERKYSKD 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 342 QILLYYLNNVYLGHGAFGFASAAEFYFRKTPSELNTEEMIVLASLASAPNRFSPLKNPDLSRQRVNAIVHSFQKQEIL-- 419
Cdd:COG0744  166 EILELYLNTVYFGRGAYGIEAAAQYYFGKSASDLTLAEAALLAGLVKAPSYYDPYRNPEAAKERRNLVLDRMVEQGYItq 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 420 KENPKPKLDEIYLAfhmrspgETVFGNRKDDSPYVTEHVRKFLNSLYPDSNIYeTGGFSIHTTIAEPVQAELSKIVKNYL 499
Cdd:COG0744  246 AEADAAKAEPLTLV-------PPPNGAAAGKYPYFVDYVRRELEELLGEDDLY-RGGLKIYTTLDPKLQKAAEKAVKNVL 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 500 DNiqksglvrktkltdnknssetavfrkyvqdispalelfidtdsfggKSESGLQVALVAVDPATGEILLMHGGSEFKaD 579
Cdd:COG0744  318 PE----------------------------------------------GKPGGLQAALVVVDPKTGEVLAMVGGRDYG-K 350

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 580 NQLDRTTAMKRQTGSSIKPILYSAAIETElISASSRILDAPLIYRNqtGNWMPENIGNQYDGDISVRHALAKSKNTAAVQ 659
Cdd:COG0744  351 SQFNRATQAKRQPGSTFKPFVYAAALEQG-YTPATTVDDEPVTFPG--GGWSPKNYDGRYRGPVTLREALANSLNTPAVR 427

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 660 IAEKLGISKIQDFFQKYFFPDPkvlqsrFRGDLSLALGSLEISPLEMALAYSAFANDGTIKRPYLIQKITDRSGKIVYER 739
Cdd:COG0744  428 LAQEVGLDKVVDTARRLGITSP------LDPNPSLALGTSEVSPLEMASAYATFANGGVYVEPHAITKVTDADGKVLYEA 501

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 740 KstdefglkvPEERKVLSSQVAEIMIDLLH-----GSANSAGVRSTgyrgEVAGKTGTTNDNRDNWFVGVKPGMSMAIWL 814
Cdd:COG0744  502 K---------PKCEQVISPEVAYLMTDMLQdvvtsGTGRAARLPGR----PVAGKTGTTNDNRDAWFVGYTPQLVTAVWV 568

                        650       660       670       680       690       700
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 499991323 815 GYDDPSyGLGsSALGGTVAAPLWGSV-AKTFEATEDEKRKYPVTEHAISITVCEESGKLPGPSC 877
Cdd:COG0744  569 GNDDNS-PMG-YVTGGSLPAPIWRDFmEAALEGLPVEDFPKPSGVVRIDEPSPTPSGTEPTETS 630
PBP_1a_fam TIGR02074
penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan ...
 256-849 3.56e-163

penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273955 [Multi-domain]  Cd Length: 531  Bit Score: 487.15  E-value: 3.56e-163
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323  256 DAYPENLKKIVLLVEDRKFFSHSGINYMSVLRAAFVNIASFRFKQGASTITQQLARILLDDREKSLVRKIKEAQLAFALE 335
Cdd:TIGR02074   8 DDIPENLINAFLAIEDRRFYDHFGIDLKGIGRAAVANITSGRVLEGGSTITQQLAKNLYLTNERTITRKIQEALLALKLE 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323  336 YTYEKKQILLYYLNNVYLGHGAFGFASAAEFYFRKTPSELNTEEMIVLASLASAPNRFSPLKNPDLSRQRVNAIVHSFQK 415
Cdd:TIGR02074  88 QKLSKDEILELYLNRIYFGNGAYGIEAAAQFYFGKSVNDLTLAEAAMLAGLPKAPSAYNPFKNPERAKDRRNLVLSNMVE 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323  416 QEILKENPKPKLDEIYLAFHMRSPGEtvfgnRKDDSPYVTEHVRKFLNSLYPDsNIYeTGGFSIHTTIAEPVQAELSKIV 495
Cdd:TIGR02074 168 NGYITAEEAEEAINEPIQLYLQTKKS-----EQYKAPYFVDYVIQELEEEYGE-ELY-TGGLKIYTTLDLDAQKAAEKVL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323  496 KNYLDNiqksglvrktkltdnknssetavfrkyvqdispalelfidtdsFGGKSESGLQVALVAVDPATGEILLMHGGSE 575
Cdd:TIGR02074 241 NTGLRV-------------------------------------------AGRRDGDDLQAALVAIDPDTGAVRALVGGRD 277

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323  576 FKaDNQLDRTTAMKRQTGSSIKPILYSAAIETeLISASSRILDAPLIYrNQTGNWMPENIGNQYDGDISVRHALAKSKNT 655
Cdd:TIGR02074 278 YG-KSQFNRATQAKRQPGSTFKPFVYAAALEK-GLTPATIVNDEPITY-NGNGPWSPKNYGGGYRGNVTLRQALAQSRNI 354

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323  656 AAVQIAEKLGISKIQDFFQKYFFPDPKVLqsrfrgDLSLALGSLEISPLEMALAYSAFANDGTIKRPYLIQKITDRSGKI 735
Cdd:TIGR02074 355 PAVRLLQEVGLDKVVALAKRFGITSPLDP------VLSLALGTVEVSPLEMASAYAVFANGGKYVEPHGIRKIVDRDGKV 428

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323  736 VYERKstdefglkvPEERKVLSSQVAEIMIDLL-----HGSANSAgvRSTGYrgEVAGKTGTTNDNRDNWFVGVKPGMSM 810
Cdd:TIGR02074 429 IYENK---------PKTTQVISPATAYIMTDMLkgvveSGTGRSA--RLPGR--PVAGKTGTTQNWRDAWFVGYTPYYVT 495

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|
gi 499991323  811 AIWLGYDDP-SYGLGSSalGGTVAAPLWGSVAKtfEATED 849
Cdd:TIGR02074 496 AVWVGYDDKkTLGKSGT--GGGLAAPIWRDFMA--EALKN 531
PbpC COG4953
Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope ...
 192-896 1.46e-92

Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443980 [Multi-domain]  Cd Length: 773  Bit Score: 309.84  E-value: 1.46e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 192 LSAGVIISLLLVGMILFWVGVITreselkeMISLFYNHQPS-VIYDRDGKkVSEIFAkkTSNLEW------DAYPENLKK 264
Cdd:COG4953   10 RLLALLLALLLLALALWALDRLF-------PLPLLFAVPYStVVLDRDGT-LLRAFL--AADGQWrlpvplDEVSPRYLQ 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 265 IVLLVEDRKFFSHSGINYMSVLRAAFVNIASFRFKQGASTITQQLARiLLDDREKSLVRKIKEAQLAFALEYTYEKKQIL 344
Cdd:COG4953   80 ALLAYEDRRFYYHPGVNPLALLRAAWQNLRSGRIVSGGSTLTMQVAR-LLEPRPRTLSGKLRQILRALQLERRYSKDEIL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 345 LYYLNNVYLGHGAFGFASAAEFYFRKTPSELNTEEMIVLASLASAPNRFSPLKNPDLSRQRVNAIVHSFQKQEILkenPK 424
Cdd:COG4953  159 ELYLNLAPYGGNIEGVEAASLAYFGKPPSRLSLAEAALLAVLPQAPSRRRPDRNPERARAARDRVLARLAEAGVI---DA 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 425 PKLDEIYLafhmrspgETVFGNRKDdSPYVTEHVRKFLNSLYPDSNIyetggfsIHTTIAEPVQAELSKIVKNYLDNIQK 504
Cdd:COG4953  236 EEAALALL--------EPVPARRRP-LPQLAPHLARRLLRQLPGGTR-------IRTTLDAGLQRRLERLVRRYVRRLKQ 299

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 505 SGlvrktkltdnknssetavfrkyvqdispalelfidtdsfggksesGLQVALVAVDPATGEILLMHGGSEFKAD---NQ 581
Cdd:COG4953  300 NG---------------------------------------------IHNAAVLVVDNRTGEVLAYVGSADFFDAsrqGQ 334

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 582 LDRTTAmKRQTGSSIKPILYSAAIETELISASSRILDAPLiyrnQTGNWMPENIGNQYDGDISVRHALAKSKNTAAVQIA 661
Cdd:COG4953  335 VDMVRA-LRSPGSTLKPFLYGLALDQGLIHPETLLADVPT----SFGGYRPENFDGTFQGPVSAREALARSLNIPAVRLL 409

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 662 EKLGISKIQDFFQKYFFPDpkVLQSRFRGDLSLALGSLEISPLEMALAYSAFANDGTIKRPYLIQkitdrsgkivyerks 741
Cdd:COG4953  410 EALGPARFYARLRRAGLRL--LLPPAEHYGLSLILGGAEVTLEELVGLYAALARGGEARPLRLLA--------------- 472

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 742 tdefGLKVPEERKVLSSQVAEIMIDLLHGSA---NSAGVRSTGYRGEVAGKTGTTNDNRDNWFVGVKPGMSMAIWLGydD 818
Cdd:COG4953  473 ----GEPASPGRRLLSPGAAWLVRDILSDVPrpdGAFGWRALDSPPPIAWKTGTSYGFRDAWAVGFTGRYTVGVWVG--N 546

                        650       660       670       680       690       700       710
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 499991323 819 PSyGLGSSAL-GGTVAAPLWGSVAKTFEATEDEkRKYPVTEHAISITVCEESGKLPGPSCKHPRKELFKNGTVPSEICP 896
Cdd:COG4953  547 PD-GTPVPGLtGAEAAAPLLFDIFDLLPASRWP-LPFPPPAGLLRVEVCAPSGLLAGPNCPQRVTEWFIPGTSPPTLCP 623
mrcA PRK11636
penicillin-binding protein 1a; Provisional
 231-893 1.46e-88

penicillin-binding protein 1a; Provisional


Pssm-ID: 183248 [Multi-domain]  Cd Length: 850  Bit Score: 300.89  E-value: 1.46e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 231 PSVIYDRDGKKVSEIFAKKTSNLEWDAYPENLKKIVLLVEDRKFFSHSGINYMSVLRAAFVNIASFRFKQGASTITQQLA 310
Cdd:PRK11636  47 PMQVYSADGELIAQYGEKRRIPLTLDQIPPEMVKAFIATEDSRFYEHHGVDPVGIFRAASVALFSGHASQGASTITQQLA 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 311 RILLDDREKSLVRKIKEAQLAFALEYTYEKKQILLYYLNNVYLGHGAFGFASAAEFYFRKTPSELNTEEMIVLASLASAP 390
Cdd:PRK11636 127 RNFFLSPERTLMRKIKEAFLAIRIEQLLTKDEILELYLNKIYLGYRAYGVGAAAQVYFGKTVDQLTLSEMAVIAGLPKAP 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 391 NRFSPLKNPDLSRQRVNAIV-----HSFQKQEILKENPKPKLDEIYLAfhmrsPgETVFGnrkddSPYVTEHVRKFLNSL 465
Cdd:PRK11636 207 STFNPLYSMDRAVARRNVVLsrmldEGYITQAQYDQARSEPIVANYHA-----P-EIAFS-----APYLSEMVRQEMYNR 275

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 466 YPDsNIYeTGGFSIHTTIAEPVQAELSKIVKN----Y-----------------------------LDNIQKSGLVRKTK 512
Cdd:PRK11636 276 YGE-NAY-EDGYRVYTTITRKVQQAAQQAVRNnvldYdmrhgyrgpanvlwkvgesawdnkkitdtLKALPTYGPLLPAV 353

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 513 LTDNKNSSETAVFRKyvqdiSPALELFID---------TDSFGGKS--------ESGLQV-------------------A 556
Cdd:PRK11636 354 VTSANPQEATAMLAD-----GSSVALPMEgvrwarpyrSDTQQGPTprkvtdvvQTGQQIwvrqvddawwlaqvpdvnsA 428

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 557 LVAVDPATGEILLMHGGSEFkadNQ--LDRTTAMKRQTGSSIKPILYSAAIETELISASsrIL-DAPlIYRNQTG---NW 630
Cdd:PRK11636 429 LVSINPQNGAVMALVGGFDF---NQskFNRATQALRQVGSNIKPFLYTAAMDKGLTLAS--MLnDVP-ISRWDAGagsDW 502

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 631 MPENIGNQYDGDISVRHALAKSKNTAAVQIAEKLGISKIQDFFQKYFFPDPKVLQSRfrgdlSLALGSLEISPLEMALAY 710
Cdd:PRK11636 503 RPKNSPPQYAGPIRLRQGLGQSKNVVMVRAMRAMGVDYAAEYLQRFGFPAQNIVHTE-----SLALGSASFTPMQVARGY 577

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 711 SAFANDGTIKRPYLIQKITDRSGKIVYERK---STDEFGLKV--------------------------------PEERKV 755
Cdd:PRK11636 578 AVMANGGFLVDPYFISKIENDQGGVIFEAKpkvACPECDIPViygdtqksnvlenddvenvatsqeqqnssvpmPQLEQA 657

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 756 LSSQVAEI--------MID-----LLHGSANS-----AGVRSTGYRG-------EVAGKTGTTNDNRDNWFVGVKPGMSM 810
Cdd:PRK11636 658 NQALVAQNgaqeyaphVINtplafLIKSALNTnifgePGWMGTGWRAgrdlkrrDIGGKTGTTNSSKDAWFSGYGPGVVT 737

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 811 AIWLGYDDPSYGLGSSALGGTV-------------AAPLWGSVAKTFEATEDEKRKYPvTEHAISITVCEESGKLP--GP 875
Cdd:PRK11636 738 SVWIGFDDHRRDLGRTTASGAIkdqisgyeggaksAQPAWDDYMKAALEGVPEQPLTP-PPGIVTVNIDRSTGKLAngGN 816

                        810
                 ....*....|....*...
gi 499991323 876 SckhpRKELFKNGTVPSE 893
Cdd:PRK11636 817 S----REEYFIEGTQPTQ 830
PBP_1c TIGR02073
penicillin-binding protein 1C; This subfamily of the penicillin binding proteins includes the ...
 229-900 4.08e-87

penicillin-binding protein 1C; This subfamily of the penicillin binding proteins includes the member from E. coli designated penicillin-binding protein 1C. Members have both transglycosylase and transpeptidase domains and are involved in forming cross-links in the late stages of peptidoglycan biosynthesis. All members of this subfamily are presumed to have the same basic function. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273954 [Multi-domain]  Cd Length: 727  Bit Score: 293.94  E-value: 4.08e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323  229 HQPS--VIYDRDGKKVSEIFAKKTS-NLEWDAY--PENLKKIVLLVEDRKFFSHSGINYMSVLRAAFVNIASFRFKQGAS 303
Cdd:TIGR02073   7 HRPSstVVLDRHGTLLRALLANDGQwRLPVPLEdiSPKFLQALLLYEDKRFYWHPGVNPLALLRAAWQNLTNGRRVSGGS 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323  304 TITQQLARILLDDREKSLVRKIKEAQLAFALEYTYEKKQILLYYLNNVYLGHGAFGFASAAEFYFRKTPSELNTEEMIVL 383
Cdd:TIGR02073  87 TLTMQLARLLDPELSRTLTGKLRQMWRAIQLEARYSKREILEAYLNLAPYGGNLEGLRAASLIYFGKEPSSLSLAEAALL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323  384 ASLASAPNRFSPLKNPDL---SRQRVNAIVH-----SFQKQEILKENPKPKLDEiylafHMrspgetvfgnrkddsPYVT 455
Cdd:TIGR02073 167 AALPQAPSARRLDRLPKAakaARDRLLDRMVeqgpdDSEQVALAALEPLPALPE-----PL---------------PQLA 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323  456 EH-VRKFLNSLYPDSNIyetggfsIHTTIAEPVQAELSKIVKNYLDniqksglvrktkltdnknssetavfRKYVQDISP 534
Cdd:TIGR02073 227 PHfALKLLRARPEIASV-------IVSTLDADLQRRLEELARRYLS-------------------------ALRPRGISN 274

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323  535 ALELFIDTDSfggksesglqvalvavdpatGEILLMHGGSEFKAD---NQLDRTTAMkRQTGSSIKPILYSAAIETELIS 611
Cdd:TIGR02073 275 LAILVVDNRS--------------------GAVLAYVGSADFFDDsnsGQVDGVRAP-RSPGSTLKPFLYALALDDGLLH 333

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323  612 ASSRILDAPLiyrnQTGNWMPENIGNQYDGDISVRHALAKSKNTAAVQIAEKLGISKIQDFFQKYFFPDPKVlQSRFRGd 691
Cdd:TIGR02073 334 PDSLLKDVPL----RFGDYAPENFDKTFHGPVPAREALARSLNIPAVRLLERVGPPRFADFLRQAGLNLLKP-KSDYYG- 407

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323  692 LSLALGSLEISPLEMALAYSAFANDGTIKRPYLIQkitdrsgkivyerkstdeFGLKVPEERKVLSSQVAEIMIDLLHGS 771
Cdd:TIGR02073 408 LSLALGGAEITLQDLANLYAMLANQGLSGPLRFLQ------------------TDAKRPERERLLSPGAAWIVLDILKDR 469

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323  772 ---ANSAGVRSTGYRGEVAGKTGTTNDNRDNWFVGVKPGMSMAIWLGYDDpsyGLGSSAL-GGTVAAPLWGSVAKTFEAT 847
Cdd:TIGR02073 470 prpDDTLPLSALPTRLPLAWKTGTSYGFRDAWAAGVSGRYTIGVWVGNFD---GKPNPGFfGAAAAAPLLFDILDALQAS 546

                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|...
gi 499991323  848 EDEKRKYPVTEHAIsitvCEESGKLPGPSCKHPRKELFKNGTVPSEICPLNHG 900
Cdd:TIGR02073 547 EASTLPRPLKEVPG----CLVLGNLPILPCPEQISTWFLPGGSPPTLSEPHKP 595
PBP_1b TIGR02071
penicillin-binding protein 1B; Bacterial that synthesize a cell wall of peptidoglycan (murein) ...
 256-818 1.61e-83

penicillin-binding protein 1B; Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of a particular bifunctional transglycosylase/transpeptidase in E. coli and other Proteobacteria, designated penicillin-binding protein 1B. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273952 [Multi-domain]  Cd Length: 730  Bit Score: 283.92  E-value: 1.61e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323  256 DAYPENLKKIVLLVEDRKFFSHSGINYMSVLRAAFVNIASFRFKQGASTITQQLARILLDDREKSLVRKIKEAQLAFALE 335
Cdd:TIGR02071 153 DQFPELLVDTLLATEDRDFYEHDGISLYSIGRAVWVNLTAGRTVQGGSTLTQQLVKNLFLSNERSLWRKANEAYMALILD 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323  336 YTYEKKQILLYYLNNVYLGH-GA---FGFASAAEFYFRKTPSELNTEEMIVLASLASAPNRFSPLKNPDLSRQRVNAIVH 411
Cdd:TIGR02071 233 ARYSKDRILELYLNEVYLGQsGDdaiHGFPLASQYYFGRPLGELSLDQVALLVGMVKGPSYYNPWRNPDRALERRNLVLR 312

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323  412 SFQKQEILKenpkpklDEIYLAFHMRSPGETVFGNRKDDSPYVTEHVRKFLNSLYPDsNIYETGGFSIHTTIaEPVQael 491
Cdd:TIGR02071 313 LLQEQKIID-------DEEYDMLSARPLGVQKKGGIISRQPAFLQLVRRELRQKLGD-KVKDLSGLRIFTTL-DPVS--- 380

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323  492 skivknyldniqksglvrktkltdnKNSSETAvfrkyVQDISPALElfidtdsfGGKSESGLQVALVAVDPATGEILLMH 571
Cdd:TIGR02071 381 -------------------------QSAAEQA-----VQETIPALK--------KKKKLPDLEAAMVVTDRFTGEVRAMV 422

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323  572 GGSEFKADNqLDRTTAMKRQTGSSIKPILYSAAIET-ELISASSRILDAPLIYRNQTGN-WMPENIGNQYDGDISVRHAL 649
Cdd:TIGR02071 423 GGSDPQFAG-FNRALQARRQIGSLVKPAVYLTALSQpDKYRLNTWIEDQPLSIKLSNGQvWSPQNYDRRYSGTVMLYDAL 501

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323  650 AKSKNTAAVQIAEKLGISKIQDFFQKYffpdpKVLQSRFRGDLSLALGSLEISPLEMALAYSAFANDGTIKRPYLIQKIT 729
Cdd:TIGR02071 502 AHSLNIPTVNLGMKVGLPKVSQTWNKL-----GINKDEIPPVPSMLLGAINLTPYEVAQLYQTIASGGNRAPLSAVRSVL 576

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323  730 DRSGKIVYErkstdefglKVPEERKVLSSQVAEIMIDLLHGSANSAGVRSTGYRG---EVAGKTGTTNDNRDNWFVGVKP 806
Cdd:TIGR02071 577 DEDGKVLYQ---------SDPQAEQAVPSQAAYLTLYAMQQVVQRGTARSLGADFpslSLAGKTGTTNDNRDSWFAGIDG 647

                         570
                  ....*....|..
gi 499991323  807 GMSMAIWLGYDD 818
Cdd:TIGR02071 648 KEVTIIWLGRDD 659
Transgly pfam00912
Transglycosylase; The penicillin-binding proteins are bifunctional proteins consisting of ...
 238-409 7.34e-70

Transglycosylase; The penicillin-binding proteins are bifunctional proteins consisting of transglycosylase and transpeptidase in the N- and C-terminus respectively. The transglycosylase domain catalyzes the polymerization of murein glycan chains.


Pssm-ID: 459993 [Multi-domain]  Cd Length: 177  Bit Score: 228.95  E-value: 7.34e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323  238 DGKKVSEIFAKKTSNLEWDAYPENLKKIVLLVEDRKFFSHSGINYMSVLRAAFVNIASFRFKQGASTITQQLARILLDDR 317
Cdd:pfam00912   1 DGTLLAELGEENREYVPLDDIPPALKNAVLAIEDRRFYEHGGVDPKGIARALLSNLRSGRIVQGGSTITQQLAKNLFLTP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323  318 EKSLVRKIKEAQLAFALEYTYEKKQILLYYLNNVYLGHGAFGFASAAEFYFRKTPSELNTEEMIVLASLASAPNRFSPLK 397
Cdd:pfam00912  81 ERTLTRKLKEAVLALKLERRYSKDEILEAYLNTVYFGRGAYGIEAAARAYFGKDASDLTLAEAALLAGLPQAPSRYNPLR 160

                         170
                  ....*....|..
gi 499991323  398 NPDLSRQRVNAI 409
Cdd:pfam00912 161 NPERAKRRRNLV 172
PRK14850 PRK14850
penicillin-binding protein 1b; Provisional
 232-818 8.33e-60

penicillin-binding protein 1b; Provisional


Pssm-ID: 237835 [Multi-domain]  Cd Length: 764  Bit Score: 218.18  E-value: 8.33e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 232 SVIYDRDGKKVSEIFAKKtsnlewdaYPENLKKIVLLVEDRKFFSHSGINYMSVLRAAFVNIASFRFKQGASTITQQLAR 311
Cdd:PRK14850 147 AMLYSPEGKKRLFIPRNQ--------YPEMLIKTLLAIEDKYFYEHDGIHLSSIGRAFLVNLMSGHTIQGGSTLTQQLVK 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 312 ILLDDREKSLVRKIKEAQLAFALEYTYEKKQILLYYLNNVYLGHGA----FGFASAAEFYFRKTPSELNTEEMIVLASLA 387
Cdd:PRK14850 219 NLFLTNTRSLWRKINEIYMALILDRFYSKDRILELYLNEVYLGQDGneqiRGFPLASIYYFGRPINELNLDQYALLVGMV 298

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 388 SAPNRFSPLKNPDLSRQRVNAIVHSFQKQEILKENPKPKLdeiylafhmrspgetvfgnrkddspyvtehVRKFLNsLYP 467
Cdd:PRK14850 299 KGASLYNPWTNPNLTLKRRNLVLFLLYKQKVITRKLYKDL------------------------------CSRPLN-VQS 347

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 468 DSNIyetggFSIHTTIAEPVQAELSKIVKNYLDNIqkSGLVRKTKLT-DNKNSSETAVfRKYVQDISPALELfidtdsfg 546
Cdd:PRK14850 348 KGNI-----ISSHPAFIQLVCEEFHKKIHYPFKNF--SGTKIFTTLDyISQNAAEQAV-KIGIPILKRKKRL-------- 411

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 547 gkseSGLQVALVAVDPATGEILLMHGGS--EFkadNQLDRTTAMKRQTGSSIKPILYSAAI-ETELISASSRILDAPLIY 623
Cdd:PRK14850 412 ----KDLEVAMVIIDRFSGEVRALIGSSkpEF---NGYNRALKARRSIGSLSKPITYLTALsQPEKYHLNTWISDTPISI 484

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 624 RNQTGN-WMPENIGNQYDGDISVRHALAKSKNTAAVQIAEKLGISKIQDFF------QKYFFPDPkvlqsrfrgdlSLAL 696
Cdd:PRK14850 485 KLDNGQyWTPKNNNFSFSGKVMLIDALIHSINIPTVHLSINLGLKKLVDSWillgisSNYITPLP-----------SISL 553

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 697 GSLEISPLEMALAYSAFANDGTIKRPYLIQKITDRSGKIVYErkstdefglKVPEERKVLSSQVAEIMIDLLHGSANSAG 776
Cdd:PRK14850 554 GAINLTPMEVAQVFQIIGSGGYKSSLSSIRSIISDDNKVLYQ---------NFPQSKHVESSQASYLTLYAMQQVVKSGT 624

                        570       580       590       600
                 ....*....|....*....|....*....|....*....|....*
gi 499991323 777 VRSTGYRGE---VAGKTGTTNDNRDNWFVGVKPGMSMAIWLGYDD 818
Cdd:PRK14850 625 AKSLGTIFKefsLAGKTGTTNNLVDSWFVGIDGKQVVITWIGRDN 669
mrcB PRK09506
bifunctional glycosyl transferase/transpeptidase; Reviewed
 258-818 3.08e-59

bifunctional glycosyl transferase/transpeptidase; Reviewed


Pssm-ID: 236544 [Multi-domain]  Cd Length: 830  Bit Score: 217.72  E-value: 3.08e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 258 YPENLKKIVLLVEDRKFFSHSGINYMSVLRAAFVNIASFRFKQGASTITQQLARILLDDREKSLVRKIKEAQLAFALEYT 337
Cdd:PRK09506 219 FPDLLVDTLLATEDRHFYEHDGISLYSIGRAVLANLTAGRTVQGGSTLTQQLVKNLFLSNERSLWRKANEAYMALIMDAR 298

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 338 YEKKQILLYYLNNVYLGHGA----FGFASAAEFYFRKTPSELNTEEMIVLASLASAPNRFSPLKNPDLSRQRVNAIVHSF 413
Cdd:PRK09506 299 YSKDRILELYLNEVYLGQSGddqiRGFPLASLYYFGRPVEELSLDQQALLVGMVKGASLYNPWRNPKLALERRNLVLRLL 378

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 414 QKQEILKEnpkpkldEIYLAFHMRSPGETVFGNRKDDSPYVTEHVRKFLNSLYPDsNIYETGGFSIHTTIaEPVqaelsk 493
Cdd:PRK09506 379 QQQQIIDQ-------ELYDMLSARPLGVQPKGGVISPQPAFMQMVRQELQAKLGD-KVKDLSGVKIFTTL-DPV------ 443

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 494 ivknyldniqksglvrktkltdnknSSETAvfRKYVQDISPALElfidtdsfGGKSESGLQVALVAVDPATGEILLMHGG 573
Cdd:PRK09506 444 -------------------------SQDAA--EKAVEEGIPALK--------KQRKLSDLETAMVVVDRFSGEVRAMVGG 488

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 574 SE--FKADNqldRTTAMKRQTGSSIKPILYSAAI-ETELISASSRILDAPLIYRNQTGN-WMPENIGNQYDGDISVRHAL 649
Cdd:PRK09506 489 SEpqFAGYN---RAMQARRSIGSLAKPATYLTALsQPDKYRLNTWIADAPISLRQPNGQvWSPQNDDRRFSGRVMLVDAL 565

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 650 AKSKNTAAVQIAEKLGISKIQDFFQKYFFPdPKVLQSRfrgdLSLALGSLEISPLEMALAYSAFANDGTIKRPYLIQKIT 729
Cdd:PRK09506 566 TRSMNVPTVNLGMALGLPAVTDTWIKLGVP-KDQLNPV----PAMLLGALNLTPIEVAQAFQTIASGGNRAPLSALRSVI 640

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 730 DRSGKIVYErkstdefglKVPEERKVLSSQVAEIMIDLL-----HGSANSAGVRSTGYrgEVAGKTGTTNDNRDNWFVGV 804
Cdd:PRK09506 641 AEDGKVLYQ---------SFPQAERAVPAQAAYLTLYTMqqvvqRGTGRQLGAKYPNL--HLAGKTGTTNDLVDSWFAGI 709

                        570
                 ....*....|....
gi 499991323 805 KPGMSMAIWLGYDD 818
Cdd:PRK09506 710 DGKEVTITWVGRDN 723
FtsI COG0768
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
 548-842 2.32e-39

Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440531 [Multi-domain]  Cd Length: 568  Bit Score: 154.60  E-value: 2.32e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 548 KSESGlqvALVAVDPATGEILLM--------HGGSEFKADNQLDRTTamkRQT---GSSIKPILYSAAIETELISASSRI 616
Cdd:COG0768  245 KAKSG---AVVVMDPKTGEILAMasypsfdpNLFVGGPDEPLRNRAV---QGTyepGSTFKPFTAAAALEEGVITPDTTF 318

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 617 LD-APLIYRNQT-GNWMPENIGNqydgdISVRHALAKSKNTAAVQIAEKLGISKIQDFFQKYFF---------------- 678
Cdd:COG0768  319 DCpGYYRVGGRTiRDWDRGGHGT-----LTLTEALAKSSNVGFYKLALRLGIDKLYDYLKKFGLgqktgidlpgeasgll 393

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 679 PDPKvlqSRFRGDL-SLALG-SLEISPLEMALAYSAFANDGTIKRPYLIQKITDRSGKIVYErkstdefglKVPEERKVL 756
Cdd:COG0768  394 PSPK---RWYPGETaTMSIGqGLSVTPLQLAQAYAAIANGGVLVKPHLVKEIVDPDGEVVKE---------EPEVLRRVI 461

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 757 SSQVAEIMIDLLHGSANSAG-----VRSTGYRgeVAGKTGT-----------TNDNRDNWFVGVKPgmsmaiwlgYDDPS 820
Cdd:COG0768  462 SPETAETVREGMEGVVNEPGgtarrAAIPGYR--VAGKTGTaqvvdignggyYKGRHIASFVGFAP---------ADNPR 530

                        330       340
                 ....*....|....*....|....*....
gi 499991323 821 Y-------GLGSSALGGTVAAPLWGSVAK 842
Cdd:COG0768  531 YavavvveNPGGGAYGGTVAAPVFREIME 559
PRK11240 PRK11240
penicillin-binding protein 1C; Provisional
 270-891 4.47e-36

penicillin-binding protein 1C; Provisional


Pssm-ID: 183049 [Multi-domain]  Cd Length: 772  Bit Score: 146.77  E-value: 4.47e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 270 EDRKFFSHSGINYMSVLRAAFVNIASFRFKQGASTITQQLARiLLDDREKSLVRKIKEAQLAFALEYTYEKKQILLYYLN 349
Cdd:PRK11240  82 EDRWFWKHPGVNPFSVARAAWQDLTSGRVISGGSTLTMQVAR-LLDPHPRTFGGKIRQLWRALQLEWHLSKREILTLYLN 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 350 NVYLGHGAFGFASAAEFYFRKTPSELNTEEMIVLASLASAPNRFSPLKNPD---------LSRQRVNAIVHSFQKQEILK 420
Cdd:PRK11240 161 RAPFGGTLQGIGAASWAYLGKSPANLSYAEAALLAVLPQAPSRLRPDRWPEraeaarnkvLERMAEQGVWSAEQVKESRE 240

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 421 EN----PK--PKLDEIyLAFHMrspgetvfgNRKDDSPyvtehvrkflnslypdsniyetggfSIHTTIAEPVQAELSKI 494
Cdd:PRK11240 241 EPvwlaPRqmPQLAPL-FARMM---------LGKSKSD-------------------------KIVTTLDAGLQRRLEDL 285

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 495 VKNYldniqKSGLVRKTKLTDNKNSSETAVFRKYVQDISpalelFIDTDSFGgksesglqvalvavdpatgeillmhggs 574
Cdd:PRK11240 286 ALNW-----KGRLPPRSSLAMIVVDHTDMAVRGWVGSVD-----LNDDSRFG---------------------------- 327

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 575 efkadnQLDRTTAMkRQTGSSIKPILYSAAIETELISASSRILDAPliyrNQTGNWMPENIGNQYDGDISVRHALAKSKN 654
Cdd:PRK11240 328 ------HVDMVNAI-RSPGSVLKPFVYGLALDDGLIHPASLLQDVP----RRTGDYRPGNFDSGFHGPVSMSEALVRSLN 396

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 655 TAAVQIAEKLGiskiqdffqkyffpdPKVLQSRFRG-------------DLSLALGSLEISPLEMALAYSAFANDGTIKR 721
Cdd:PRK11240 397 LPAVQVLEAYG---------------PKRFAAKLRNvglplylpagaepNLSLILGGAGARLEDMVAAYSAFARHGKAAK 461

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 722 PYLI--QKITdrsgkivyerkstdefglkvpeERKVLSSQVAEIMIDLLHGSANSAGVRSTGYRGEVAGKTGTTNDNRDN 799
Cdd:PRK11240 462 LRLQpdDPLL----------------------ERPLMSPGAAWIIRRIMADEAQPLPDAALPRVVPLAWKTGTSYGYRDA 519

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 800 WFVGVKPGMSMAIWLGYDDPS-----YGLGSsalggtvAAPLWGSVAKTFEATEDEKRKY-PVTEHAISI---TVCEESG 870
Cdd:PRK11240 520 WAIGVNARYVIGIWTGRPDGTpvvgqFGFAS-------AVPLLNQVNNLLLSRSSQRGANlPEDPRPASVsrgVICWPGG 592

                        650       660
                 ....*....|....*....|....
gi 499991323 871 K-LP--GPSCKHPRKELFKNGTVP 891
Cdd:PRK11240 593 QsLPegDSNCRRRLATWLLDGSQP 616
Transpeptidase pfam00905
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss: ...
 556-836 1.44e-33

Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.


Pssm-ID: 425939 [Multi-domain]  Cd Length: 296  Bit Score: 131.38  E-value: 1.44e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323  556 ALVAVDPATGEILLMHGGSEF----KADNQLDRTTAMKRQTGSSIKPILYSAAIETELISASSRILDAPLIYRNQT--GN 629
Cdd:pfam00905   2 SAVVLDPKTGEVLAMVGKPSYdpngFIGPLRNRAVTSRYEPGSTFKPFTALAALDNGVLKPDETIFDWPGKQQGGKsiGD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323  630 WmpeNIGNQYDGDIsvRHALAKSKNTAAVQIAEKLGISKIQDFFQKYFF--PDPKVLQSRFRGDL--------SLALG-S 698
Cdd:pfam00905  82 W---NQDQVGIGTL--RQALEYSSNWYMQKLAQKLGADKLRSYLKKFGYgnKTGIGLPGENAGYLtpywlegaTASFGiG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323  699 LEISPLEMALAYSAFANDGTIKRPYLIQKITDRsgkivyerkstdefgLKVPEERK-VLSSQVAEIMIDLLHGSANSAGV 777
Cdd:pfam00905 157 LTITPLQQAQAYAAIANGGKLVPPHLVKSIEDK---------------VDPKVLNKlPISKSTAEKVKDMLRLVVNDGTG 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323  778 RST----GYRgeVAGKTGTT-----------NDNRDNWFVGVKPgmsmaiwlgYDDPSYGL------GSSALGGTVAAPL 836
Cdd:pfam00905 222 TGTaavpGYK--VAGKTGTAqvagpkgggyyDGAQIGWFVGYAP---------ADNPKYAFavliddPKRYYGGKVAAPI 290
pbp2_mrdA TIGR03423
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ...
 536-836 5.06e-29

penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 274573 [Multi-domain]  Cd Length: 592  Bit Score: 123.40  E-value: 5.06e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323  536 LELFIDTD-------SFGGKSesGlqvALVAVDPATGEILLMH--------------GGSEFKADNQLDRTTAMKRQT-- 592
Cdd:TIGR03423 228 LVLTIDARlqqaaekALGGRR--G---AVVVMDPRTGEILAMVstpsfdpnlfvdgiSSKDYKALLNDPDRPLLNRAIqg 302

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323  593 ----GSSIKPILYSAAIETELISASSRILDapliyrnqTGNWmpeNIGNQY--------DGDISVRHALAKSKNTAAVQI 660
Cdd:TIGR03423 303 vyppGSTFKPVVALAALEEGVITPETRIYC--------PGYF---QLGGRRfrcwkrggHGRVDLRKAIEESCDVYFYQL 371

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323  661 AEKLGISKIQDFFQKYFF----------------PDPKVLQSRFR-----GD-LSLALGS--LEISPLEMALAYSAFAND 716
Cdd:TIGR03423 372 ALRLGIDKIAEYAKRFGFgqktgidlpgeksglvPSREWKRKRFGqpwypGDtLNVSIGQgyVLVTPLQLAVATAALANG 451

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323  717 GTIKRPYLIQKITDRSGKIVYErkstdefgLKVPEERKV-LSSQVAEIMIDLLHGSANsaGVRSTGYRG------EVAGK 789
Cdd:TIGR03423 452 GKLYKPHLVKSIEDPDGGVVRR--------TEPEVLRPLpISPENLDVVREGMRDVVN--GPGGTARRArlglpyKMAGK 521

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 499991323  790 TGT-----------------TNDNRDN-WFVGVKPgmsmaiwlgYDDPSY--------GLGssalGGTVAAPL 836
Cdd:TIGR03423 522 TGTaqvvslkqgekydaeqiPERLRDHaLFVAFAP---------YDNPKIavavivehGGG----GSSAAAPI 581
mono_pep_trsgly TIGR02070
monofunctional biosynthetic peptidoglycan transglycosylase; This family is one of the ...
 255-409 1.35e-25

monofunctional biosynthetic peptidoglycan transglycosylase; This family is one of the transglycosylases involved in the late stages of peptidoglycan biosynthesis. Members tend to be small, about 240 amino acids in length, and consist almost entirely of a domain described by pfam00912 for transglycosylases. Species with this protein will have several other transglycosylases as well. All species with this protein are Proteobacteria that produce murein (peptidoglycan). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273951 [Multi-domain]  Cd Length: 224  Bit Score: 106.01  E-value: 1.35e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323  255 WDAYPENLKKIVLLVEDRKFFSHSGINYMSVLRAAFVNIASFRFKQGASTITQQLARILLDDREKSLVRKIKEAQLAFAL 334
Cdd:TIGR02070  60 YDQISPNLKRAVIASEDAKFVEHHGFDWEAIQDALEKNEKSGKVVRGGSTISQQLAKNLFLWSGRSYLRKGLEAWATWML 139

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 499991323  335 EYTYEKKQILLYYLNNVYLGHGAFGFASAAEFYFRKTPSELNTEEMIVLASLASAPNRFSPLKNPDLSRQRVNAI 409
Cdd:TIGR02070 140 ETWWSKQRILEVYLNSVEWGNGVFGAEAAARYYFKRSASNLTRGQAARLAAVLPNPKYYDENRPGPYVRRKATWI 214
PRK13481 PRK13481
glycosyltransferase; Provisional
 248-422 1.88e-24

glycosyltransferase; Provisional


Pssm-ID: 184078 [Multi-domain]  Cd Length: 232  Bit Score: 102.96  E-value: 1.88e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 248 KKTSNLEWDAYPENLKKIVLLVEDRKFFSHSGINYMSVLRAAFVNIaSFRFKQGASTITQQLARILLDDREKSLVRKIKE 327
Cdd:PRK13481  43 NKSSFVSADNMPEYVKGAFISMEDERFYKHHGFDLKGTTRALFSTI-SDRDVQGGSTITQQVVKNYFYDNERSFTRKVKE 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 328 AQLAFALEYTYEKKQILLYYLNNVYLGHGAFGFASAAEFYFRKT--PSELNTEEMIVLAS--LASAPNRFSPLKNPDLS- 402
Cdd:PRK13481 122 LFVAHRVEKQYSKNEILSFYLNNIYFGDNQYTLEGAANHYFGTTvnKNSTTMSHITVLQSaiLASKVNAPSVYNINDMSe 201

                        170       180
                 ....*....|....*....|..
gi 499991323 403 --RQRVNAIVHSFQKQEILKEN 422
Cdd:PRK13481 202 nfTQRVSTNLEKMKQQNYINET 223
PRK15105 PRK15105
peptidoglycan synthase FtsI; Provisional
 548-840 4.66e-06

peptidoglycan synthase FtsI; Provisional


Pssm-ID: 185060 [Multi-domain]  Cd Length: 578  Bit Score: 50.20  E-value: 4.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 548 KSESGlqvALVAVDPATGEILLMHGGSEFKADNQLDRTT-AMKRQT-------GSSIKPILYSAAIETELISASSRIlda 619
Cdd:PRK15105 255 KAESG---SAVLVDVNTGEVLAMANSPSYNPNNLSGTPKdAMRNRAitdvfepGSTVKPMVVMTALQRGVVKENSVL--- 328

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 620 pliyrnqtgNWMPENIGNQYDGDI------SVRHALAKSKNTAAVQIAEKLGISKIQDFFQKYFFPDPKVL--------- 684
Cdd:PRK15105 329 ---------NTVPYRINGHEIKDVaryselTLTGVLQKSSNVGVSKLALAMPSSALVDTYSRFGLGKATNLglvgersgl 399

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 685 ---QSRF----RGDLSLALGsLEISPLEMALAYSAFANDGtIKRPYLIQKITDrsgkivyerkstdefglKVPEERkVLS 757
Cdd:PRK15105 400 ypqKQRWsdieRATFSFGYG-LMVTPLQLARVYATIGSYG-IYRPLSITKVDP-----------------PVPGER-VFP 459

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499991323 758 SQVAEIMIDLLHGSA--NSAGVRST--GYRgeVAGKTGTTND-NRDNWFV--------GVKPGMS--MAIWLGYDDPSYG 822
Cdd:PRK15105 460 ESIVRTVVHMMESVAlpGGGGVKAAikGYR--IAIKTGTAKKvGPDGRYInkyiaytaGVAPASQprFALVVVINDPQAG 537

                        330
                 ....*....|....*...
gi 499991323 823 lgsSALGGTVAAPLWGSV 840
Cdd:PRK15105 538 ---KYYGGAVSAPVFGAI 552
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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