|
Name |
Accession |
Description |
Interval |
E-value |
| PRK08662 |
PRK08662 |
nicotinate phosphoribosyltransferase; Reviewed |
1-390 |
0e+00 |
|
nicotinate phosphoribosyltransferase; Reviewed
Pssm-ID: 236328 [Multi-domain] Cd Length: 343 Bit Score: 605.33 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 1 MRFYIANERDILDGKMTDIYFDRTIRTLEHLGiKDLKVRMEVHSYGLPeGYSWAIFSGLEEVLKLLEGKEVTVYAMPEGT 80
Cdd:PRK08662 2 MRFYIASEEEIKSGKTTDIYFERTVEILEHAG-KNPKVVAEVTASSLP-KGEWGVFAGLEEVLELLEGKPVDVYALPEGT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 81 VFKEVEPVMIIEGNYLDFGVFETAFLGILRHYSSISTKAARIKKLALDKTVLFFGLRALHPAIAPMVDRAAYIGGCDGVS 160
Cdd:PRK08662 80 LFDPKEPVMRIEGPYLEFGIYETALLGILAHASGIATAAARCKEAAGDKPVLSFGARHVHPAIAPMMDRAAYIGGCDGVS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 161 GAFNQETIGAEPTGTMPHALMLSVGDNVKAWKAFDEAMPSNVPRIILADTFEDERTEVLKAAELLKDKLYGVRLDTPSSR 240
Cdd:PRK08662 160 GVLGAELLGIEPSGTMPHALILIFGDQVEAWKAFDEVVPPDVPRIALVDTFKDEREEALRAAEALGDRLDGVRLDTPSSR 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 241 RGNFRKIVQEIRWTLNIHGYGHIKIFVSGGIDEDDVVKLRDVVDGFGVGTSISFPQSVDFSADIVEKYVNgqwiPFTKRG 320
Cdd:PRK08662 240 RGNFRKIVREVRWTLDIRGYEHVKIFVSGGLDPERIRELRDVVDGFGVGTYISFAPPVDFSMDIVEVEGK----PIAKRG 315
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 321 KWPGAKQVyrcgdspdgdiitllddyppanlnckpllvkyiengkiirdiPTAKEIREYVISQLKKLPNL 390
Cdd:PRK08662 316 KLPGIKQV------------------------------------------PRLKEIREYVLEQLEELGLS 343
|
|
| NAPRTase_B |
cd01571 |
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate ... |
14-322 |
9.40e-166 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products.
Pssm-ID: 238805 [Multi-domain] Cd Length: 302 Bit Score: 465.98 E-value: 9.40e-166
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 14 GKMTDIYFDRTIRTLEHLGiKDLKVRMEVHSYGLPegysWAIFSGLEEVLKLLEGKEVTVYAMPEGTVFKEVEPVMIIEG 93
Cdd:cd01571 1 GRFTDVYFLRTRKILEKKG-PNPTVTMEFTQRSLP----WAVLCGLEEVLALLEGLPVKVYALPEGTIFNPKEPVLRIEG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 94 NYLDFGVFETAFLGILRHYSSISTKAARIKKLALDKTVLFFGLRALHPAIAPMVDRAAYIGGCDGVSGAFNQETIGAEPT 173
Cdd:cd01571 76 PYQDFGELETAILGILARASSIATNAARVKLAAGDKPVISFGDRRDHPAIQPMDGRAAYIGGCDGVSTVLGAELLGEKPS 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 174 GTMPHALMLSVG-DNVKAWKAFDEAMPSNVPRIILADTFEDERTEVLKAAELLKDKLYGVRLDTPSSRRGNFRKIVQEIR 252
Cdd:cd01571 156 GTMPHALIQIFGgDQVEAWKAFDETYPEDVPRIALIDTFNDEKEEALKAAKALGDKLDGVRLDTPSSRRGVFRYLIREVR 235
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499597559 253 WTLNIHGYGHIKIFVSGGIDEDDVVKLRDV-VDGFGVGTSISFPQSVDFSADIVEkyVNGQwiPFTKRGKW 322
Cdd:cd01571 236 WALDIRGYKHVKIFVSGGLDEEDIKELEDVgVDAFGVGTAISKAPPVDFTMDIVE--VNGQ--PIAKRGKL 302
|
|
| PncB |
COG1488 |
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ... |
47-388 |
1.37e-66 |
|
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis
Pssm-ID: 441097 [Multi-domain] Cd Length: 445 Bit Score: 217.71 E-value: 1.37e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 47 LPEGYSWAIFSGLEEVLKLLEGKEVT-----------------------------VYAMPEGTVFKEVEPVMIIEGNYLD 97
Cdd:COG1488 38 LPFGRGYVVFAGLQRFLKYLENLRFTeediaylrslgvfdedfldyladfrfpgdIRAVPEGTVVFPGEPLLTVEGTLPE 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 98 FGVFETAFLGILRHYSSISTKAARIKKLALDKTVLFFGLRALH-----PAIApmvdRAAYIGGCDGVSgafnqeTIGAE- 171
Cdd:COG1488 118 AQLLETLLLNILNYPTLIATKAARIVQAAGGRPLHDFGLRRAHgleaaVAAA----RAAYLAGFAGTS------NVLAGr 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 172 -----PTGTMPHALMLSVGDNVKAWKAFDEAMPSNVprIILADTFEDER--TEVLKAAELL--KDKLYGVRLDTpssrrG 242
Cdd:COG1488 188 yygipSVGTMAHSFVQAHDDELEAFRAFAEAYPDGT--TLLVDTYDTLSgvPNAIELAKELlaRGGLLGIRLDS-----G 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 243 NFRKIVQEIRWTLNIHGYGHIKIFVSGGIDEDDVVKLRDV---VDGFGVGTSISfpQSVDF-SADIVEKYV----NGQWI 314
Cdd:COG1488 261 DLAYLSKQARELLDEAGLPDVRIIASDDLDEYRIAALLEQgapIDVFGVGTRLV--TSSDRpTLGFVYKLVavegDGEWR 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 315 PFTKR----GK--WPGAKQVYRcgDSPDG----DIITLLDDYPPAnlNCKPLLVKYIENGKIIRDIPTAKEIREYVISQL 384
Cdd:COG1488 339 PVIKLsetpGKksKPGRKQVYR--RDEDGkataDLVALEDEPLPG--EPEPLLVPVFRDGKLVYELPSLEEIRERAAAQL 414
|
....
gi 499597559 385 KKLP 388
Cdd:COG1488 415 AELP 418
|
|
| NAPRTase_put |
TIGR01513 |
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of ... |
32-388 |
2.76e-59 |
|
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of proteins, one of which includes experimentally characterized examples of nicotinate phosphoribosyltransferase, an the first enzyme of NAD salvage biosynthesis. This model represents the other family. Members have a different (longer) spacing of several key motifs and have an additional C-terminal domain of up to 100 residues. One argument suggesting that this family represents the same enzyme is that no species has a member of both families. Another is that the gene encoding this protein is located near other NAD salvage biosynthesis genes in Nostoc and in at least four different Gram-positive bacteria. NAD and NADP are ubiquitous in life. Most members of this family are Gram-positive bacteria. An additional set of mutually closely related archaeal sequences score between the trusted and noise cutoffs. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]
Pssm-ID: 273666 [Multi-domain] Cd Length: 443 Bit Score: 198.74 E-value: 2.76e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 32 GIKDLKVRMEVHSYGLPEGYSWAIFSGLEEVLKLLEGK-----------------------------EVTVYAMPEGTVF 82
Cdd:TIGR01513 19 GKANQPAVFEVFFRKLPFGRGYAVFAGLEDLLEFLENFrfdaedieylaslgifddafldylrefrfSGTVRALPEGSLV 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 83 KEVEPVMIIEGNYLDFGVFETAFLGILRHYSSISTKAARIKKLALDKTVLFFGLRALH-PAIAPMVDRAAYIGGCDGVSG 161
Cdd:TIGR01513 99 FPNEPLLQVEGPLIEAQLLETLVLNIINFQTLIATKAARIVLAAGGKPLLEFGLRRAQgPDAALKAARAAYIGGADGTSN 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 162 AFNQETIGAEPTGTMPHALMLSVGDNVKAWKAFDEAMPSNVprIILADTFEDERT---EVLKAAELLKD--KLYGVRLDT 236
Cdd:TIGR01513 179 VLAGRLYGIPVSGTMAHSFVMSFDNELAAFRAYAKLYPKAT--VLLVDTYDTLRSglpNAIAVAKELGEqgKVVGVRIDS 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 237 pssrrGNFRKIVQEIRWTLNIHGYGHIKIFVSGGIDEDDVVKLRDV---VDGFGVGTSISFPQSvDFSADIVEKYVNGQW 313
Cdd:TIGR01513 257 -----GDLLYLSKQARKQLDAAGLTQVKIVVSNDLDENSIAALKAEgapIDVYGVGTSLVTASD-APALGGVYKLVAYEG 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 314 IPFTKR----GK--WPGAKQVYR---CGDSPDGDIITLLD---------DYPPANLNCKPLLVKYIENGKIIRDIPTAKE 375
Cdd:TIGR01513 331 RPVMKLsenpEKstLPGRKQVFRlydATGKFLGDELTLADepiedlnqeKCTPVFAPVEPLLRLVMKNGQRVRPLPSLAE 410
|
410
....*....|...
gi 499597559 376 IREYVISQLKKLP 388
Cdd:TIGR01513 411 IRARAREQLSKLP 423
|
|
| QRPTase_C |
pfam01729 |
Quinolinate phosphoribosyl transferase, C-terminal domain; Quinolinate phosphoribosyl ... |
115-303 |
1.24e-22 |
|
Quinolinate phosphoribosyl transferase, C-terminal domain; Quinolinate phosphoribosyl transferase (QPRTase) or nicotinate-nucleotide pyrophosphorylase EC:2.4.2.19 is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyzes the reaction of quinolinic acid with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to give rise to nicotinic acid mononucleotide (NaMN), pyrophosphate and carbon dioxide. The QA substrate is bound between the C-terminal domain of one subunit, and the N-terminal domain of the other. The C-terminal domain has a 7 beta-stranded TIM barrel-like fold.
Pssm-ID: 396337 Cd Length: 169 Bit Score: 93.53 E-value: 1.24e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 115 ISTKAARIKKLALDKTVLFFGLRALHPAIAPMVDRAAYIGGCD----GVSGAfnqetigaeptGTMPHALMLSVGDNVKA 190
Cdd:pfam01729 1 IATATRRMVEAARSVKVRIADTRKTTPGLRPLEKYAVLIGGGDnhrlGLSDM-----------VMIKDNHIAAAGSITEA 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 191 WKAFDEAMPSNVPRIILADTFEdERTEVLKA-AELlkdklygVRLDTPSSrrGNFRKIVQEIRWTlnihgYGHIKIFVSG 269
Cdd:pfam01729 70 VRRARQVAPFAVKIEVEVESLE-EAEEALEAgADI-------IMLDNFSP--EEVKKAVEELDER-----NPRVLLEVSG 134
|
170 180 190
....*....|....*....|....*....|....*
gi 499597559 270 GIDEDDVVKLRD-VVDGFGVGTSISFPQSVDFSAD 303
Cdd:pfam01729 135 GVTLDNVLEYAKtGVDVISVGALTHSVPPLDISLD 169
|
|
| NAPRTase_C |
pfam17956 |
Nicotinate phosphoribosyltransferase C-terminal domain; This domain is found at the C-terminus ... |
326-388 |
7.76e-10 |
|
Nicotinate phosphoribosyltransferase C-terminal domain; This domain is found at the C-terminus of some Nicotinate phosphoribosyltransferase enzymes. The function of this domain is uncertain.
Pssm-ID: 465585 [Multi-domain] Cd Length: 111 Bit Score: 56.04 E-value: 7.76e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 326 KQVYRCGD---SPDGDIITLLDDYPPA--------------------NLNCKPLLVKYIENGKIIRDIPTAKEIREYVIS 382
Cdd:pfam17956 2 KQVYRLYDkdgKAIADLITLADEPPPDpgeeilcfhpfdewkrktvtPFTVEPLLKPVFEDGKLVYELPTLEEIRAYVQE 81
|
....*.
gi 499597559 383 QLKKLP 388
Cdd:pfam17956 82 QLSRLW 87
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK08662 |
PRK08662 |
nicotinate phosphoribosyltransferase; Reviewed |
1-390 |
0e+00 |
|
nicotinate phosphoribosyltransferase; Reviewed
Pssm-ID: 236328 [Multi-domain] Cd Length: 343 Bit Score: 605.33 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 1 MRFYIANERDILDGKMTDIYFDRTIRTLEHLGiKDLKVRMEVHSYGLPeGYSWAIFSGLEEVLKLLEGKEVTVYAMPEGT 80
Cdd:PRK08662 2 MRFYIASEEEIKSGKTTDIYFERTVEILEHAG-KNPKVVAEVTASSLP-KGEWGVFAGLEEVLELLEGKPVDVYALPEGT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 81 VFKEVEPVMIIEGNYLDFGVFETAFLGILRHYSSISTKAARIKKLALDKTVLFFGLRALHPAIAPMVDRAAYIGGCDGVS 160
Cdd:PRK08662 80 LFDPKEPVMRIEGPYLEFGIYETALLGILAHASGIATAAARCKEAAGDKPVLSFGARHVHPAIAPMMDRAAYIGGCDGVS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 161 GAFNQETIGAEPTGTMPHALMLSVGDNVKAWKAFDEAMPSNVPRIILADTFEDERTEVLKAAELLKDKLYGVRLDTPSSR 240
Cdd:PRK08662 160 GVLGAELLGIEPSGTMPHALILIFGDQVEAWKAFDEVVPPDVPRIALVDTFKDEREEALRAAEALGDRLDGVRLDTPSSR 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 241 RGNFRKIVQEIRWTLNIHGYGHIKIFVSGGIDEDDVVKLRDVVDGFGVGTSISFPQSVDFSADIVEKYVNgqwiPFTKRG 320
Cdd:PRK08662 240 RGNFRKIVREVRWTLDIRGYEHVKIFVSGGLDPERIRELRDVVDGFGVGTYISFAPPVDFSMDIVEVEGK----PIAKRG 315
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 321 KWPGAKQVyrcgdspdgdiitllddyppanlnckpllvkyiengkiirdiPTAKEIREYVISQLKKLPNL 390
Cdd:PRK08662 316 KLPGIKQV------------------------------------------PRLKEIREYVLEQLEELGLS 343
|
|
| NAPRTase_B |
cd01571 |
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate ... |
14-322 |
9.40e-166 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products.
Pssm-ID: 238805 [Multi-domain] Cd Length: 302 Bit Score: 465.98 E-value: 9.40e-166
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 14 GKMTDIYFDRTIRTLEHLGiKDLKVRMEVHSYGLPegysWAIFSGLEEVLKLLEGKEVTVYAMPEGTVFKEVEPVMIIEG 93
Cdd:cd01571 1 GRFTDVYFLRTRKILEKKG-PNPTVTMEFTQRSLP----WAVLCGLEEVLALLEGLPVKVYALPEGTIFNPKEPVLRIEG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 94 NYLDFGVFETAFLGILRHYSSISTKAARIKKLALDKTVLFFGLRALHPAIAPMVDRAAYIGGCDGVSGAFNQETIGAEPT 173
Cdd:cd01571 76 PYQDFGELETAILGILARASSIATNAARVKLAAGDKPVISFGDRRDHPAIQPMDGRAAYIGGCDGVSTVLGAELLGEKPS 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 174 GTMPHALMLSVG-DNVKAWKAFDEAMPSNVPRIILADTFEDERTEVLKAAELLKDKLYGVRLDTPSSRRGNFRKIVQEIR 252
Cdd:cd01571 156 GTMPHALIQIFGgDQVEAWKAFDETYPEDVPRIALIDTFNDEKEEALKAAKALGDKLDGVRLDTPSSRRGVFRYLIREVR 235
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499597559 253 WTLNIHGYGHIKIFVSGGIDEDDVVKLRDV-VDGFGVGTSISFPQSVDFSADIVEkyVNGQwiPFTKRGKW 322
Cdd:cd01571 236 WALDIRGYKHVKIFVSGGLDEEDIKELEDVgVDAFGVGTAISKAPPVDFTMDIVE--VNGQ--PIAKRGKL 302
|
|
| NAPRTase_PncB |
cd01567 |
Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase ... |
16-299 |
1.29e-71 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products.
Pssm-ID: 238801 [Multi-domain] Cd Length: 343 Bit Score: 227.54 E-value: 1.29e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 16 MTDIYFDRTIRTLEHlGIKDLKVRMEVHSYGLPEGYSWAIFSGLEEVLKLLEGK-------------------------- 69
Cdd:cd01567 3 DTDLYKLTMMQAYLY-PYPNTRVVFEFTFRSNPFGGDYIVFAGLEEVLKLLENLrfteeeieylkkllifgefflyllfl 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 70 ---EVTVYAMPEGTVFKEVEPVMIIEGNYLDFGVFETAFLGILRHYSSISTKAARIKKLA------------LDKTVLFF 134
Cdd:cd01567 82 gklPLEIYALPEGTVVFPKEPLLTIEGPWPEAGLLETPLLAIWNEATSIATKAARKKLAAgglletkdnleeLGFKLHDF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 135 GLRALH-PAIAPMVDRAAYIGGCDGVSGAFNQETIGAEPTGTMPHALMLSVGD-NVKAWKAFDEAMP--SNVPRIILADT 210
Cdd:cd01567 162 GTRRRHsPEAALSGGRAALIGGFGGTSNVAAAKKLGIPPIGTMAHSWIQAFGAlEEAAFEAFARWLPqfGGGLGIALIDT 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 211 FEDERtEVLKAAELLK-----DKLYGVRLDTpssrrGNFRKIVQEIRWTLNIHGY--GHIKIFVSGGIDEDDVVK-LRD- 281
Cdd:cd01567 242 YDTDN-GFLNALKLAKalgagGGLLGVRLDS-----GDPVELIKKVRKHLDELGIdlNKKKIIISGDLDTEEAIElLLEq 315
|
330 340
....*....|....*....|.
gi 499597559 282 ---VVDGFGVGTSISFPQSVD 299
Cdd:cd01567 316 gasPNDAFGVGTSLTNDLGRP 336
|
|
| PncB |
COG1488 |
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ... |
47-388 |
1.37e-66 |
|
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis
Pssm-ID: 441097 [Multi-domain] Cd Length: 445 Bit Score: 217.71 E-value: 1.37e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 47 LPEGYSWAIFSGLEEVLKLLEGKEVT-----------------------------VYAMPEGTVFKEVEPVMIIEGNYLD 97
Cdd:COG1488 38 LPFGRGYVVFAGLQRFLKYLENLRFTeediaylrslgvfdedfldyladfrfpgdIRAVPEGTVVFPGEPLLTVEGTLPE 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 98 FGVFETAFLGILRHYSSISTKAARIKKLALDKTVLFFGLRALH-----PAIApmvdRAAYIGGCDGVSgafnqeTIGAE- 171
Cdd:COG1488 118 AQLLETLLLNILNYPTLIATKAARIVQAAGGRPLHDFGLRRAHgleaaVAAA----RAAYLAGFAGTS------NVLAGr 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 172 -----PTGTMPHALMLSVGDNVKAWKAFDEAMPSNVprIILADTFEDER--TEVLKAAELL--KDKLYGVRLDTpssrrG 242
Cdd:COG1488 188 yygipSVGTMAHSFVQAHDDELEAFRAFAEAYPDGT--TLLVDTYDTLSgvPNAIELAKELlaRGGLLGIRLDS-----G 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 243 NFRKIVQEIRWTLNIHGYGHIKIFVSGGIDEDDVVKLRDV---VDGFGVGTSISfpQSVDF-SADIVEKYV----NGQWI 314
Cdd:COG1488 261 DLAYLSKQARELLDEAGLPDVRIIASDDLDEYRIAALLEQgapIDVFGVGTRLV--TSSDRpTLGFVYKLVavegDGEWR 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 315 PFTKR----GK--WPGAKQVYRcgDSPDG----DIITLLDDYPPAnlNCKPLLVKYIENGKIIRDIPTAKEIREYVISQL 384
Cdd:COG1488 339 PVIKLsetpGKksKPGRKQVYR--RDEDGkataDLVALEDEPLPG--EPEPLLVPVFRDGKLVYELPSLEEIRERAAAQL 414
|
....
gi 499597559 385 KKLP 388
Cdd:COG1488 415 AELP 418
|
|
| PRTase_typeII |
cd00516 |
Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an ... |
18-303 |
1.14e-65 |
|
Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate phosphoribosyltransferase (NAPRTase), to be used in the synthesis of NAD. QAPRTase catalyses the reaction of quinolinic acid (QA) with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to produce nicotinic acid mononucleotide (NAMN), pyrophosphate and carbon dioxide, an important step in the de novo synthesis of NAD. NAPRTase catalyses a similar reaction leading to NAMN and pyrophosphate, using nicotinic acid an PPRP as substrates, used in the NAD salvage pathway.
Pssm-ID: 238286 [Multi-domain] Cd Length: 281 Bit Score: 210.17 E-value: 1.14e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 18 DIYFDRTIRTLehlGIKDLKVRMEVHSYGLPEGyswaIFSGLEEVLKLLEGKE----VTVYAMPEGTVFKEVEPVMIIEG 93
Cdd:cd00516 1 DLYKLTMIQAY---PPPDTRATAEFTAREDPYG----VLAGLEEALELLELLRfpgpLVILAVPEGTVVEPGEPLLTIEG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 94 NYLDFGVFETAFLGILRHYSSISTKAARIKKLA--LDKTVLFFGLRALHPAIAPMVDRAAYIGGCDGVSGAFNQETIGAE 171
Cdd:cd00516 74 PARELLLLERVLLNLLQRLSGIATATARYVEAAkgANTKVHDFGTRKTTPGLRLLEKYAVLIGGGDGHRNGLSDAILIKD 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 172 PTGTMPHALMLSVgDNVKAWKAFDEAMPsnVPRIILADTFEDERTEVLKAAELLkdKLYGVRLDTPSSRRGNFRKIVQEI 251
Cdd:cd00516 154 NHGTMAHSIIQAF-GELAAVKALRRWLP--ELFIALIDVEVDTLEEALEAAKAG--GADGIRLDSGSPEELDPAVLILKA 228
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 499597559 252 RWTLNIHGYGHIKIFVSGGIDEDDVVKLRDV-VDGFGVGTSISFPQSVDFSAD 303
Cdd:cd00516 229 RAHLDGKGLPRVKIEASGGLDEENIRAYAETgVDVFGVGTLLHSAPPLDIVLK 281
|
|
| PRK09243 |
PRK09243 |
nicotinate phosphoribosyltransferase; Validated |
47-388 |
1.98e-60 |
|
nicotinate phosphoribosyltransferase; Validated
Pssm-ID: 236426 [Multi-domain] Cd Length: 464 Bit Score: 202.31 E-value: 1.98e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 47 LPEGYSWAIFSGLEEVLKLLE----GKEV-------------------------TVYAMPEGTVFKEVEPVMIIEGNYLD 97
Cdd:PRK09243 43 LPFGRGYAVFAGLERLLEYLEnlrfTEEDieylrslgifdedfldylrnfrftgDVRAVPEGELVFPNEPLLRVEGPLAE 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 98 FGVFETAFLGILRHYSSISTKAARIKKLALDKTVLFFGLRALHPAIAPM-VDRAAYIGGCDGVSGAFNQETIGAEPTGTM 176
Cdd:PRK09243 123 AQLLETLLLNIINFQTLIATKAARIVSAAGGRPLLEFGSRRAQGPDAAVwAARAAYIGGFDATSNVLAGKRYGIPVSGTM 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 177 PHALMLSVGDNVKAWKAFDEAMPSNVprIILADTFEDERTEVLKA---AELLKD--KLYGVRLDTpssrrGNFRKIVQEI 251
Cdd:PRK09243 203 AHSFVQAFDDEYEAFRAYAETYPDNT--VLLVDTYDTLKSGVPNAikvAKELGDgiELGGVRIDS-----GDLAYLSKKV 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 252 RWTLNIHGYGHIKIFVSGGIDEDDV--VKLRDV-VDGFGVGTSI--SFPQSVdfsADIVEKYV----NGQWIPFTK---- 318
Cdd:PRK09243 276 RKMLDEAGFTDTKIVASNDLDEYTIasLKLQGApIDGFGVGTKLvtGSDAPA---LGGVYKLVaiegEGGMIPKIKlsns 352
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 319 RGK--WPGAKQVYR---CGDSPDGDIITLLDDYPP-----------------ANLNCKPLLVKYIENGKIIRDIPTAKEI 376
Cdd:PRK09243 353 PEKvtTPGRKQVYRiydKGGKAEADVITLADEEEEeplkmfhpvhtyksktvKNFDAEPLLVPVMENGKRVYELPSLEEI 432
|
410
....*....|..
gi 499597559 377 REYVISQLKKLP 388
Cdd:PRK09243 433 RAYAAAQLASLP 444
|
|
| NAPRTase_put |
TIGR01513 |
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of ... |
32-388 |
2.76e-59 |
|
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of proteins, one of which includes experimentally characterized examples of nicotinate phosphoribosyltransferase, an the first enzyme of NAD salvage biosynthesis. This model represents the other family. Members have a different (longer) spacing of several key motifs and have an additional C-terminal domain of up to 100 residues. One argument suggesting that this family represents the same enzyme is that no species has a member of both families. Another is that the gene encoding this protein is located near other NAD salvage biosynthesis genes in Nostoc and in at least four different Gram-positive bacteria. NAD and NADP are ubiquitous in life. Most members of this family are Gram-positive bacteria. An additional set of mutually closely related archaeal sequences score between the trusted and noise cutoffs. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]
Pssm-ID: 273666 [Multi-domain] Cd Length: 443 Bit Score: 198.74 E-value: 2.76e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 32 GIKDLKVRMEVHSYGLPEGYSWAIFSGLEEVLKLLEGK-----------------------------EVTVYAMPEGTVF 82
Cdd:TIGR01513 19 GKANQPAVFEVFFRKLPFGRGYAVFAGLEDLLEFLENFrfdaedieylaslgifddafldylrefrfSGTVRALPEGSLV 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 83 KEVEPVMIIEGNYLDFGVFETAFLGILRHYSSISTKAARIKKLALDKTVLFFGLRALH-PAIAPMVDRAAYIGGCDGVSG 161
Cdd:TIGR01513 99 FPNEPLLQVEGPLIEAQLLETLVLNIINFQTLIATKAARIVLAAGGKPLLEFGLRRAQgPDAALKAARAAYIGGADGTSN 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 162 AFNQETIGAEPTGTMPHALMLSVGDNVKAWKAFDEAMPSNVprIILADTFEDERT---EVLKAAELLKD--KLYGVRLDT 236
Cdd:TIGR01513 179 VLAGRLYGIPVSGTMAHSFVMSFDNELAAFRAYAKLYPKAT--VLLVDTYDTLRSglpNAIAVAKELGEqgKVVGVRIDS 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 237 pssrrGNFRKIVQEIRWTLNIHGYGHIKIFVSGGIDEDDVVKLRDV---VDGFGVGTSISFPQSvDFSADIVEKYVNGQW 313
Cdd:TIGR01513 257 -----GDLLYLSKQARKQLDAAGLTQVKIVVSNDLDENSIAALKAEgapIDVYGVGTSLVTASD-APALGGVYKLVAYEG 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 314 IPFTKR----GK--WPGAKQVYR---CGDSPDGDIITLLD---------DYPPANLNCKPLLVKYIENGKIIRDIPTAKE 375
Cdd:TIGR01513 331 RPVMKLsenpEKstLPGRKQVFRlydATGKFLGDELTLADepiedlnqeKCTPVFAPVEPLLRLVMKNGQRVRPLPSLAE 410
|
410
....*....|...
gi 499597559 376 IREYVISQLKKLP 388
Cdd:TIGR01513 411 IRARAREQLSKLP 423
|
|
| PRK12484 |
PRK12484 |
nicotinate phosphoribosyltransferase; Provisional |
47-388 |
4.42e-47 |
|
nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 237112 [Multi-domain] Cd Length: 443 Bit Score: 166.46 E-value: 4.42e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 47 LPEGYSWAIFSGLEEVLKLLEGKEVT-----------------------------VYAMPEGTVFKEVEPVMIIEGNYLD 97
Cdd:PRK12484 37 LPDGRGFLIAAGLADVVEFLEAFRFDeqdlrylrglnqfseeflawlaglrftgdVRAVPEGTVVFPNEPLLEVTAPLIE 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 98 FGVFETAFLGILRHYSSISTKAARIKKLALDKTVLFFGLRALH-PAIAPMVDRAAYIGGCDGVSGAFNQETIGAEPTGTM 176
Cdd:PRK12484 117 AQLVETFLLNQINHQSLIASKAARCVLAAAGRPVVDFGARRAHgTDAACYVARASYLAGAAGTSNVLAARQYGIPASGTM 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 177 PHALMLSVGDNVKAWKAFDEAMPSNVprIILADTFEDERTeVLKAAELLKD-----KLYGVRLDTpssrrGNFRKIVQEI 251
Cdd:PRK12484 197 AHSFVEAFPDEVAAFRAFARLYPDAT--TLLVDTYDTLRG-VRNAIEVAKElgnrfDPRGVRLDS-----GDLAELSKAT 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 252 RWTLNIHGYGHIKIFVSGGIDE---DDVVKLRDVVDGFGVGTSISFPQSvDFSADIVEKYVNGQWIPFTK--RGK--WPG 324
Cdd:PRK12484 269 RAILDAAGLEQVKIVASGGLDEyriAALLAAGAPIDGFGVGTRLGVAAD-APVLDSAYKLVAYEGRGVTKlsSGKvtYPG 347
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499597559 325 AKQVYRCGDSPD--GDIITLLDDYPPAnlNCKPLLVKYIENGKIIRDIPTAKEIREYVISQLKKLP 388
Cdd:PRK12484 348 RKQVFRLYEHGTacGDVIGLHTENIPD--GREPLLVPVMTNGRRIQHAPTLDGARDWCEAQLAALP 411
|
|
| NAPRTase_A |
cd01570 |
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate ... |
47-292 |
5.60e-47 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria and eukaryota (except funghi).
Pssm-ID: 238804 [Multi-domain] Cd Length: 327 Bit Score: 163.13 E-value: 5.60e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 47 LPEGYSWAIFSGLEEVLKLLE----GKE-------------------------VTVYAMPEGTVFKEVEPVMIIEGNYLD 97
Cdd:cd01570 34 LPFGGGYAVFAGLEELLEYLEnfrfTEEdidylrslgifdeefldylrgfrftGTIYAIPEGEVVFPNEPLLTVEGPLIE 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 98 FGVFETAFLGILRHYSSISTKAARIKKLALDKTVLFFGLRALHPAIAPM-VDRAAYIGGCDGVSGAFNQETIGAEPTGTM 176
Cdd:cd01570 114 AQLLETLLLNLINFQTLIATKAARVRLAAGGRPLLEFGLRRAQGPDAALsAARAAYIGGFDGTSNVLAGKLYGIPVSGTM 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 177 PHALMLSVGDNVKAWKAFDEAMPSNVprIILADTFEDERTEVLKAAELLKD------KLYGVRLDTpssrrGNFRKIVQE 250
Cdd:cd01570 194 AHSFVQAFDDELAAFRAFAEAYPDNF--TLLVDTYDTLRSGLPNAIAVAKElgalgyRLVGVRIDS-----GDLAYLSKE 266
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 499597559 251 IRWTLNIHGYGHIKIFVSGGIDEDDVVKLRD---VVDGFGVGTSI 292
Cdd:cd01570 267 ARKMLDEAGLTKVKIVASNDLDEYTIAALNAqgaPIDAFGVGTRL 311
|
|
| PRK07188 |
PRK07188 |
nicotinate phosphoribosyltransferase; Provisional |
9-314 |
6.75e-45 |
|
nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 235953 [Multi-domain] Cd Length: 352 Bit Score: 158.19 E-value: 6.75e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 9 RDILDGKMTDIYFDRTIRTLEhLGIKDLKVRMEVHSYGLPegyswAIFSGLEEVLKLLEG-----KEVTVYAMPEGTVFK 83
Cdd:PRK07188 11 ERIGEGWYSAVYFLKTREIIE-KFNPNNIVTMQFFQRREN-----AVLCGTDEVIALLKTfakdpSKLKIRYLKDGDIIN 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 84 EVEPVMIIEGNYLDFGVFETAFLGILRHYSSISTKAARIKKLALDKTVLFFGLRALHPAIAPMVDRAAYIGGCDGVSGAF 163
Cdd:PRK07188 85 PFETVLEIEGPYENFGFLEGIIDGILARRTSVATNAYNVVQAANEKPVIFMGDRADHYLQQAGDGYAAYIGGISAFSTHA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 164 NQETIGAEPTGTMPHALM-LSVGDNVKAWKAFDEAMPSNvPRIILADTFEDERTEVLKAAELLKDKLYGVRLDT------ 236
Cdd:PRK07188 165 QNEWWGKSGFGTMPHALIqMFNGDVVEACKAYHKTFPED-ELIALVDYNNDVITDSLKVAREFGDKLKGVRVDTsknmid 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 237 -----------PSSRRGNFRKIVQEIRWTLNIHGYGHIKIFVSGGIDEDDVV---KLRDVVDGFGVGTSIsFPQSVDFSA 302
Cdd:PRK07188 244 kyfirhpevlgTFDPRGVNPELIKALRKALDENGGKHVKIIVSSGFDAKKIRefeAQNVPVDIYGVGSSL-LKINIGFTG 322
|
330
....*....|..
gi 499597559 303 DIVEkyVNGQWI 314
Cdd:PRK07188 323 DAVE--LNGKKE 332
|
|
| QRPTase_C |
pfam01729 |
Quinolinate phosphoribosyl transferase, C-terminal domain; Quinolinate phosphoribosyl ... |
115-303 |
1.24e-22 |
|
Quinolinate phosphoribosyl transferase, C-terminal domain; Quinolinate phosphoribosyl transferase (QPRTase) or nicotinate-nucleotide pyrophosphorylase EC:2.4.2.19 is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyzes the reaction of quinolinic acid with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to give rise to nicotinic acid mononucleotide (NaMN), pyrophosphate and carbon dioxide. The QA substrate is bound between the C-terminal domain of one subunit, and the N-terminal domain of the other. The C-terminal domain has a 7 beta-stranded TIM barrel-like fold.
Pssm-ID: 396337 Cd Length: 169 Bit Score: 93.53 E-value: 1.24e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 115 ISTKAARIKKLALDKTVLFFGLRALHPAIAPMVDRAAYIGGCD----GVSGAfnqetigaeptGTMPHALMLSVGDNVKA 190
Cdd:pfam01729 1 IATATRRMVEAARSVKVRIADTRKTTPGLRPLEKYAVLIGGGDnhrlGLSDM-----------VMIKDNHIAAAGSITEA 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 191 WKAFDEAMPSNVPRIILADTFEdERTEVLKA-AELlkdklygVRLDTPSSrrGNFRKIVQEIRWTlnihgYGHIKIFVSG 269
Cdd:pfam01729 70 VRRARQVAPFAVKIEVEVESLE-EAEEALEAgADI-------IMLDNFSP--EEVKKAVEELDER-----NPRVLLEVSG 134
|
170 180 190
....*....|....*....|....*....|....*
gi 499597559 270 GIDEDDVVKLRD-VVDGFGVGTSISFPQSVDFSAD 303
Cdd:pfam01729 135 GVTLDNVLEYAKtGVDVISVGALTHSVPPLDISLD 169
|
|
| PLN02885 |
PLN02885 |
nicotinate phosphoribosyltransferase |
48-387 |
7.06e-15 |
|
nicotinate phosphoribosyltransferase
Pssm-ID: 178473 [Multi-domain] Cd Length: 545 Bit Score: 75.85 E-value: 7.06e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 48 PEGYSWAIFSGLEEVLKL--------------------------------LEGKEVTVYAMPEGT-VFKEVePVMIIEGN 94
Cdd:PLN02885 46 PFGGEYTVFAGLEECLRFianfkftdddidflrsvmpsgcedaffdylrgLDCSDVEVYAIPEGSvVFPRV-PLMRIEGP 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 95 YLDFGVFETAFLGILRHYSSISTKAARIKKLA-LDKTVLFFGL-RALHPAIAPMVDRAAYIGGCDGVSGAFNQETIGAEP 172
Cdd:PLN02885 125 LAVVQLLETTFLTLVNYASLVATNAARHRLVAgKSKVLLEFGLrRAQGPDGGISASKYCYLGGFDATSNVEAGRLFGIPV 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 173 TGTMPHA---------------LMLSVGDN--------VKAWKA-----------FDE--------------AMPSNVpr 204
Cdd:PLN02885 205 RGTHSHAfvssymgldeivdktLRSADGSSvcedfvslVQEWLSklqessslrgvFSEtnqselaaftsyalAFPNSF-- 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 205 IILADTFEDERTEV---LKAAELLKDKLY---GVRLDTPS----SRRGnfRKIVQEIRWTLNIHGYGHIKIFVSGGIDED 274
Cdd:PLN02885 283 LALVDTYDVMKSGIpnfCAVALALNDLGYkavGIRLDSGDlaylSLEA--RKFFRTIEEELGVPGFGKMSITASNDINEE 360
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 275 DVVKLR---DVVDGFGVGTSI--SFPQ-SVDFSADIVEkyVNGQwiPFTK------RGKWPGAKQVYRC-GDS--PDGDI 339
Cdd:PLN02885 361 TLDALNkqgHEIDAFGIGTHLvtCYAQpALGCVYKLVE--INGQ--PRIKlsedveKVTIPCKKRCYRLyGKEgyPLVDL 436
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 340 ITLLDDYPPA---NLNCK-----------------PLLVKYIE--NGKIIRDIPTAKEIREYVISQLKKL 387
Cdd:PLN02885 437 MTGENEPPPKvgeRILCRhpfneskrayvvpqrveELLKCYWDgsSGKPREELPSLKEIRERCMKQLERM 506
|
|
| NAPRTase_C |
pfam17956 |
Nicotinate phosphoribosyltransferase C-terminal domain; This domain is found at the C-terminus ... |
326-388 |
7.76e-10 |
|
Nicotinate phosphoribosyltransferase C-terminal domain; This domain is found at the C-terminus of some Nicotinate phosphoribosyltransferase enzymes. The function of this domain is uncertain.
Pssm-ID: 465585 [Multi-domain] Cd Length: 111 Bit Score: 56.04 E-value: 7.76e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 326 KQVYRCGD---SPDGDIITLLDDYPPA--------------------NLNCKPLLVKYIENGKIIRDIPTAKEIREYVIS 382
Cdd:pfam17956 2 KQVYRLYDkdgKAIADLITLADEPPPDpgeeilcfhpfdewkrktvtPFTVEPLLKPVFEDGKLVYELPTLEEIRAYVQE 81
|
....*.
gi 499597559 383 QLKKLP 388
Cdd:pfam17956 82 QLSRLW 87
|
|
| QPRTase_NadC |
cd01568 |
Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called ... |
55-301 |
1.00e-06 |
|
Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to produce nicotinic acid mononucleotide (NAMN), pyrophosphate and carbon dioxide. QPRTase functions as a homodimer with two active sites, each formed by the C-terminal region of one subunit and the N-terminal region of the other.
Pssm-ID: 238802 [Multi-domain] Cd Length: 269 Bit Score: 49.78 E-value: 1.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 55 IFSGLE---EVLKLLEGKEVTVYAmPEGTVFKEVEPVMIIEGNYLDFGVFETAFLGILRHYSSISTKAARIKKLALDKTV 131
Cdd:cd01568 40 VLAGLEvaeEVFELLDGIEVEWLV-KDGDRVEAGQVLLEVEGPARSLLTAERVALNLLQRLSGIATATRRYVEAARGTKA 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 132 LFFGLRALHPAIAPMVDRAAYIGGCDgvsgafnqetigaeptgtmPH------ALML------SVGDNVKAWKAFDEAMP 199
Cdd:cd01568 119 RIADTRKTTPGLRLLEKYAVRAGGGD-------------------NHrlglsdAVLIkdnhiaAAGGITEAVKRARAAAP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 200 SNVPRIILADTFEdertEVLKAAELLKDklyGVRLDtpssrrgNF-----RKIVQEIRwtlnihGYGHIKIFVSGGIDED 274
Cdd:cd01568 180 FEKKIEVEVETLE----EAEEALEAGAD---IIMLD-------NMspeelKEAVKLLK------GLPRVLLEASGGITLE 239
|
250 260
....*....|....*....|....*...
gi 499597559 275 DVVKLRDV-VDGFGVGTSISFPQSVDFS 301
Cdd:cd01568 240 NIRAYAETgVDVISTGALTHSAPALDIS 267
|
|
| QRPTase_N |
pfam02749 |
Quinolinate phosphoribosyl transferase, N-terminal domain; Quinolinate phosphoribosyl ... |
31-113 |
3.36e-05 |
|
Quinolinate phosphoribosyl transferase, N-terminal domain; Quinolinate phosphoribosyl transferase (QPRTase) or nicotinate-nucleotide pyrophosphorylase EC:2.4.2.19 is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyzes the reaction of quinolinic acid with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to give rise to nicotinic acid mononucleotide (NaMN), pyrophosphate and carbon dioxide. The QA substrate is bound between the C-terminal domain of one subunit, and the N-terminal domain of the other. The N-terminal domain has an alpha/beta hammerhead fold.
Pssm-ID: 460674 [Multi-domain] Cd Length: 88 Bit Score: 42.09 E-value: 3.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 31 LGIKDLKVRMEVHSYglpegySWAIFSGLEEVLKLLE--GKEVTVYAmPEGTVFKEVEPVMIIEGNYLDFGVFETAFLGI 108
Cdd:pfam02749 11 LIPGDKKAKAVIIAK------EEGVVAGLEEAERVFEllGLEVEWLV-KDGDRVEAGDVILEIEGPARALLTAERVALNL 83
|
....*
gi 499597559 109 LRHYS 113
Cdd:pfam02749 84 LQRLS 88
|
|
| nadV |
PHA02594 |
nicotinamide phosphoribosyl transferase; Provisional |
71-378 |
5.76e-05 |
|
nicotinamide phosphoribosyl transferase; Provisional
Pssm-ID: 222898 [Multi-domain] Cd Length: 470 Bit Score: 45.02 E-value: 5.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 71 VTVYAMPEGTVFKEVEPVMIIEGNYLDF----GVFETAFLGILRHYSSISTKAARIKKL---ALDKTVLF---------- 133
Cdd:PHA02594 101 IEVRAVPEGTVVPVKVPVLTIENTHPDFfwlaGYLETVILRGVWYPSTVATLSRECKKIlkkYLKETSDNedevldfqlh 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 134 -FGLRALHPAiapmvdRAAYIGGC---------DGVS---------GAFNQETIGAEPTGTmPHALMLSVG--DNVKAWK 192
Cdd:PHA02594 181 dFGARGMSSG------ESAALGGLahlynfkgtDTVEalymakryyGDDEVEMAGISVPAR-EHSTMCSYGaeNEDEAFK 253
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 193 AFDEAMPSNVPRIIlADTFEDER--TEVLKAaelLKDKLY---GVRLDTPSSrrGNFRKIVQ---EIRW-----TLNIHG 259
Cdd:PHA02594 254 NSLTLYGTGIYSIV-SDTYDFKRavTEILPE---LKDEIMargGKLVIRPDS--GDPVDIICgalETLGeifggTVNSKG 327
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 260 Y----GHIKIFVSGGIDEDDVVKL-----------RDVVdgFGVG-------TSISFPQSVDFSADIvekyVNGQWI--- 314
Cdd:PHA02594 328 YkvldEHVRLIQGDGITLERINRIltrmkengfasENVA--FGMGggllqmvTRDTFKFAMKATAIK----INGKWKgvf 401
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499597559 315 --PFTKRGKWPGAKQVYRCGDSPDGDIITLLDDYPPANLNckPLLVKYIENGKIIRDiPTAKEIRE 378
Cdd:PHA02594 402 knPKTDEGKKSKKGRLARVKDGGSFKTVDGLEEQSEADLN--DALVTYFDDGKLVRY-QSLAEIRE 464
|
|
| PBEF_like |
cd01569 |
pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of ... |
58-131 |
9.04e-04 |
|
pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general, nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis.
Pssm-ID: 238803 [Multi-domain] Cd Length: 407 Bit Score: 41.11 E-value: 9.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 58 GLEEVLKLLEGK-EVTVYAMPEGTVFKEVEPVMIIEGNYLDF----GVFETAFLGILRHYSSISTKAARIKKL---ALDK 129
Cdd:cd01569 82 GWRHILELHDGYlPIEIRAVPEGTVVPTKNVLMTVENTDPDFfwltNYLETILLRNVWYPSTVATISREYKKIlrkYAKE 161
|
..
gi 499597559 130 TV 131
Cdd:cd01569 162 TS 163
|
|
| QPRTase |
cd01572 |
Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called ... |
54-303 |
1.47e-03 |
|
Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to produce nicotinic acid mononucleotide (NAMN), pyrophosphate and carbon dioxide. QPRTase functions as a homodimer with two active sites, each formed by the C-terminal region of one subunit and the N-terminal region of the other.
Pssm-ID: 238806 [Multi-domain] Cd Length: 268 Bit Score: 40.15 E-value: 1.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 54 AIFSGL---EEVLKLLEGK-EVTVYAmPEGTVFKEVEPVMIIEGNYLDFGVFETAFLGILRHYSSISTKAARIKKLALDK 129
Cdd:cd01572 39 GVLAGLpvaEEVFELLDPGiEVEWLV-KDGDRVEPGQVLATVEGPARSLLTAERTALNFLQRLSGIATLTRRYVEALAGT 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 130 TVLFFGLRALHPAIAPMVDRAAYIGGCD----GVSGAF----NqetigaeptgtmpH-ALMLSVGDNVKAWKafdEAMPS 200
Cdd:cd01572 118 KARILDTRKTTPGLRLLEKYAVRCGGGDnhrfGLSDAVlikdN-------------HiAAAGSITEAVRRAR---AAAPF 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499597559 201 NVPRIILADTFEDERtEVLKAaellkdKLYGVRLDtpssrrgNF-----RKIVQEIRwtlnihgyGHIKIFVSGGIDEDD 275
Cdd:cd01572 182 TLKIEVEVETLEQLK-EALEA------GADIIMLD-------NMspeelREAVALLK--------GRVLLEASGGITLEN 239
|
250 260 270
....*....|....*....|....*....|...
gi 499597559 276 VvklRDV----VDGFGVGTSI-SFPqSVDFSAD 303
Cdd:cd01572 240 I---RAYaetgVDYISVGALThSAP-ALDISLD 268
|
|
| |
