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Conserved domains on  [gi|499340629|ref|WP_011030337|]
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MULTISPECIES: helix-turn-helix transcriptional regulator [Streptomyces]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 10650117)

helix-turn-helix (HTH) domain-containing protein with an XRE (Xenobiotic Response Element) family HTH domain, binds DNA and may function as a transcriptional regulator

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|2644244|8831795
SCOP:  4000362

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
11-65 3.06e-17

Helix-turn-helix XRE-family like proteins;


:

Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 67.54  E-value: 3.06e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 499340629   11 LRQIRRQRGVTQYKLAASLGVHNTAISHYENGHRRPDVETLATIADVLGARMDDF 65
Cdd:smart00530  2 LKELREEKGLTQEELAEKLGVSRSTLSRIENGKRKPSLETLKKLAKALGVSLDEL 56
 
Name Accession Description Interval E-value
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
11-65 3.06e-17

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 67.54  E-value: 3.06e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 499340629   11 LRQIRRQRGVTQYKLAASLGVHNTAISHYENGHRRPDVETLATIADVLGARMDDF 65
Cdd:smart00530  2 LKELREEKGLTQEELAEKLGVSRSTLSRIENGKRKPSLETLKKLAKALGVSLDEL 56
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 11-65 1.09e-16

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 66.41  E-value: 1.09e-16
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 499340629  11 LRQIRRQRGVTQYKLAASLGVHNTAISHYENGHRRPDVETLATIADVLGARMDDF 65
Cdd:pfam01381  1 LKELREELGLSQEELAEKLGVSRSTISKIENGKREPSLETLKKLAEALGVSLDEL 55
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
11-68 1.14e-16

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 66.94  E-value: 1.14e-16
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 499340629 11 LRQIRRQRGVTQYKLAASLGVHNTAISHYENGHRRPDVETLATIADVLGARMDDFVTA 68
Cdd:COG1396  12 LRELRKARGLTQEELAERLGVSRSTISRIERGRRNPSLETLLKLAKALGVSLDELLGG 69
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 9-65 1.87e-16

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 65.65  E-value: 1.87e-16
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 499340629  9 DALRQIRRQRGVTQYKLAASLGVHNTAISHYENGHRRPDVETLATIADVLGARMDDF 65
Cdd:cd00093   2 ERLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKALGVSLDEL 58
CxxCG_CxxCG_HTH TIGR03830
putative zinc finger/helix-turn-helix protein, YgiT family; This model describes a family of ...
 7-46 1.13e-07

putative zinc finger/helix-turn-helix protein, YgiT family; This model describes a family of predicted regulatory proteins with a conserved zinc finger/HTH architecture. The amino-terminal region contains a novel domain, featuring two CXXC motifs and occuring in a number of small bacterial proteins as well as in the present family. The carboxyl-terminal region consists of a helix-turn-helix domain, modeled by pfam01381. The predicted function is DNA binding and transcriptional regulation.


Pssm-ID: 274805 [Multi-domain]  Cd Length: 127  Bit Score: 44.93  E-value: 1.13e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 499340629    7 SPDALRQIRRQRGVTQYKLAASLGVHNTAISHYENGHRRP 46
Cdd:TIGR03830  66 TGPEIRRIRKKLGLSQREAAELLGGGVNAFSRYERGEVRP 105
PRK09726 PRK09726
type II toxin-antitoxin system antitoxin HipB;
6-60 1.17e-05

type II toxin-antitoxin system antitoxin HipB;


Pssm-ID: 182049  Cd Length: 88  Bit Score: 39.19  E-value: 1.17e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 499340629  6 FSP----DALRQIRRQRGVTQYKLAASLGVHNTAISHYENghrRPDVETLATIADVLGA 60
Cdd:PRK09726  8 YSPtqlaNAMKLVRQQNGWTQSELAKKIGIKQATISNFEN---NPDNTTLTTFFKILQS 63
 
Name Accession Description Interval E-value
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
11-65 3.06e-17

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 67.54  E-value: 3.06e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 499340629   11 LRQIRRQRGVTQYKLAASLGVHNTAISHYENGHRRPDVETLATIADVLGARMDDF 65
Cdd:smart00530  2 LKELREEKGLTQEELAEKLGVSRSTLSRIENGKRKPSLETLKKLAKALGVSLDEL 56
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 11-65 1.09e-16

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 66.41  E-value: 1.09e-16
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 499340629  11 LRQIRRQRGVTQYKLAASLGVHNTAISHYENGHRRPDVETLATIADVLGARMDDF 65
Cdd:pfam01381  1 LKELREELGLSQEELAEKLGVSRSTISKIENGKREPSLETLKKLAEALGVSLDEL 55
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
11-68 1.14e-16

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 66.94  E-value: 1.14e-16
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 499340629 11 LRQIRRQRGVTQYKLAASLGVHNTAISHYENGHRRPDVETLATIADVLGARMDDFVTA 68
Cdd:COG1396  12 LRELRKARGLTQEELAERLGVSRSTISRIERGRRNPSLETLLKLAKALGVSLDELLGG 69
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 9-65 1.87e-16

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 65.65  E-value: 1.87e-16
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 499340629  9 DALRQIRRQRGVTQYKLAASLGVHNTAISHYENGHRRPDVETLATIADVLGARMDDF 65
Cdd:cd00093   2 ERLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKALGVSLDEL 58
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
10-67 1.34e-14

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 61.40  E-value: 1.34e-14
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 499340629 10 ALRQIRRQRGVTQYKLAASLGVHNTAISHYENGHRRPDVETLATIADVLGARMDDFVT 67
Cdd:COG1476   8 RLKELRKERGLTQEELAELLGVSRQTISAIENGKYNPSLELALKIARALGVSLEELFS 65
aMBF1 COG1813
Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and ...
 8-64 7.89e-12

Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441418 [Multi-domain]  Cd Length: 70  Bit Score: 54.17  E-value: 7.89e-12
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 499340629  8 PDALRQIRRQRGVTQYKLAASLGVHNTAISHYENGHRRPDVETLATIADVLGARMDD 64
Cdd:COG1813  14 GERIREAREARGLSQEELAEKLGVSESTIRRIERGEATPSLDTLRKLEKALGISLAE 70
AF2118 COG3620
Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain ...
 9-66 4.26e-10

Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain CBS pair) [Transcription];


Pssm-ID: 442838 [Multi-domain]  Cd Length: 95  Bit Score: 50.79  E-value: 4.26e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 499340629  9 DALRQIRRQRGVTQYKLAASLGVHNTAISHYENGHRRPDVETLATIADVLGARMDDFV 66
Cdd:COG3620  20 EALRLMRKELGLSQLPVAELVGVSQSDILRIESGKRDPTVSTLEKIAEALGKELSAVL 77
YiaG COG2944
DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription];
1-47 1.66e-09

DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription];


Pssm-ID: 442187 [Multi-domain]  Cd Length: 64  Bit Score: 48.39  E-value: 1.66e-09
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 499340629  1 MPARTFSPDALRQIRRQRGVTQYKLAASLGVHNTAISHYENGHRRPD 47
Cdd:COG2944   1 MTKKPLTPEEIRALRERLGLSQAEFAALLGVSVSTVRRWEQGRRKPS 47
HTH_19 pfam12844
Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. ...
 11-59 1.09e-08

Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. This family contains many example antitoxins from bacterial toxin-antitoxin systems. These antitoxins are likely to be DNA-binding domains.


Pssm-ID: 463728 [Multi-domain]  Cd Length: 64  Bit Score: 46.13  E-value: 1.09e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 499340629  11 LRQIRRQRGVTQYKLAASLGVHNTAISHYENGHRRPDVETLATIADVLG 59
Cdd:pfam12844  4 LRKAREERGLTQEELAERLGISRSQLSAIENGKSVPPAETLYKIAELLG 52
CxxCG_CxxCG_HTH TIGR03830
putative zinc finger/helix-turn-helix protein, YgiT family; This model describes a family of ...
 7-46 1.13e-07

putative zinc finger/helix-turn-helix protein, YgiT family; This model describes a family of predicted regulatory proteins with a conserved zinc finger/HTH architecture. The amino-terminal region contains a novel domain, featuring two CXXC motifs and occuring in a number of small bacterial proteins as well as in the present family. The carboxyl-terminal region consists of a helix-turn-helix domain, modeled by pfam01381. The predicted function is DNA binding and transcriptional regulation.


Pssm-ID: 274805 [Multi-domain]  Cd Length: 127  Bit Score: 44.93  E-value: 1.13e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 499340629    7 SPDALRQIRRQRGVTQYKLAASLGVHNTAISHYENGHRRP 46
Cdd:TIGR03830  66 TGPEIRRIRKKLGLSQREAAELLGGGVNAFSRYERGEVRP 105
couple_hipB TIGR03070
transcriptional regulator, y4mF family; Members of this family belong to a clade of ...
 9-62 7.63e-07

transcriptional regulator, y4mF family; Members of this family belong to a clade of helix-turn-helix DNA-binding proteins, among the larger family pfam01381 (HTH_3; Helix-turn-helix). Members are similar in sequence to the HipB protein of E. coli. Genes for members of the seed alignment for this protein family were found to be closely linked to genes encoding proteins related to HipA. The HibBA operon appears to have some features in common with toxin-antitoxin post-segregational killing systems. [Regulatory functions, DNA interactions]


Pssm-ID: 213767 [Multi-domain]  Cd Length: 58  Bit Score: 41.49  E-value: 7.63e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 499340629   9 DALRQIRRQRGVTQYKLAASLGVHNTAISHYENGHRRPDVETLATIADVLGARM 62
Cdd:TIGR03070  5 ILVRARRKALGLTQADLADLAGVGLRFIRDLENGKPTVRLDKVLRVLDALGLEL 58
VapI COG3093
Plasmid maintenance system antidote protein VapI, contains XRE-type HTH domain [Defense ...
 18-59 1.40e-06

Plasmid maintenance system antidote protein VapI, contains XRE-type HTH domain [Defense mechanisms];


Pssm-ID: 442327 [Multi-domain]  Cd Length: 87  Bit Score: 41.33  E-value: 1.40e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 499340629 18 RGVTQYKLAASLGVHNTAISHYENGHRRPDVETLATIADVLG 59
Cdd:COG3093  21 LGLSQTELAKALGVSRQRISEILNGKRAITADTALRLARAFG 62
HTH_26 pfam13443
Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to ...
 11-67 2.21e-06

Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433211 [Multi-domain]  Cd Length: 63  Bit Score: 40.22  E-value: 2.21e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 499340629  11 LRQIRRQRGVTQYKLAASLGVHNTAISHYENG-HRRPDVETLATIADVLGARMDDFVT 67
Cdd:pfam13443  2 LRKLMADRGISKSDLARATGISRATLSRLRKGkPKRVSLDTLDKICDALGCQPGDLLE 59
HTH_31 pfam13560
Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.
 11-60 2.62e-06

Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433309 [Multi-domain]  Cd Length: 64  Bit Score: 40.20  E-value: 2.62e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 499340629  11 LRQIRRQRGVTQYKLAASLGVHNTAISHYENG-HRRPDVETLATIADVLGA 60
Cdd:pfam13560  6 LRRLRERAGLSQEALARRLGVSRSTLSRLETGrRGRPSPAVVERLARALGV 56
PRK09726 PRK09726
type II toxin-antitoxin system antitoxin HipB;
6-60 1.17e-05

type II toxin-antitoxin system antitoxin HipB;


Pssm-ID: 182049  Cd Length: 88  Bit Score: 39.19  E-value: 1.17e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 499340629  6 FSP----DALRQIRRQRGVTQYKLAASLGVHNTAISHYENghrRPDVETLATIADVLGA 60
Cdd:PRK09726  8 YSPtqlaNAMKLVRQQNGWTQSELAKKIGIKQATISNFEN---NPDNTTLTTFFKILQS 63
PRK09706 PRK09706
transcriptional repressor DicA; Reviewed
 1-58 1.87e-05

transcriptional repressor DicA; Reviewed


Pssm-ID: 182039 [Multi-domain]  Cd Length: 135  Bit Score: 39.45  E-value: 1.87e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 499340629   1 MPARTFSpDALRQIRRQRGVTQYKLAASLGVHNTAISHYENGHRRPDVETLATIADVL 58
Cdd:PRK09706   1 MKNLTLG-QRIRYRRKQLKLSQRSLAKAVKVSHVSISQWERDETEPTGKNLFALAKAL 57
PRK09943 PRK09943
HTH-type transcriptional regulator PuuR;
11-65 2.18e-05

HTH-type transcriptional regulator PuuR;


Pssm-ID: 182158 [Multi-domain]  Cd Length: 185  Bit Score: 39.78  E-value: 2.18e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 499340629  11 LRQIRRQRGVTQYKLAASLGVHNTAISHYENGHRRPDVETLATIADVLGARMDDF 65
Cdd:PRK09943  12 LSEIRQQQGLSQRRAAELSGLTHSAISTIEQDKVSPAISTLQKLLKVYGLSLSEF 66
PHA01976 PHA01976
helix-turn-helix protein
 8-63 4.50e-05

helix-turn-helix protein


Pssm-ID: 177330 [Multi-domain]  Cd Length: 67  Bit Score: 37.24  E-value: 4.50e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 499340629  8 PDALRQIRRQRGVTQYKLAASLGVHNTAISHYENGHRRPDVETLATIADVLGARMD 63
Cdd:PHA01976  4 AIQLIKARNARAWSAPELSRRAGVRHSLIYDFEADKRLPNLKTLLRLADALGVTLD 59
COG1395 COG1395
Predicted transcriptional regulator [Transcription];
8-60 5.43e-05

Predicted transcriptional regulator [Transcription];


Pssm-ID: 441005 [Multi-domain]  Cd Length: 313  Bit Score: 38.66  E-value: 5.43e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 499340629   8 PDALRQIRRQRGVTQYKLAASLGVHNTAISHYENGHRRPDVETLATIADVLGA 60
Cdd:COG1395  129 GEKLRELREERGLSLGELASELGVSRRTISKYERGEMDASIEVALKLEEILGE 181
PRK04140 PRK04140
transcriptional regulator;
9-60 2.16e-04

transcriptional regulator;


Pssm-ID: 235224 [Multi-domain]  Cd Length: 317  Bit Score: 37.14  E-value: 2.16e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 499340629   9 DALRQIRRQRGVTQYKLAASLGVHNTAISHYENGHRRPDVETLATIADVLGA 60
Cdd:PRK04140 129 DVLREAREELGLSLGELASELGVSRRTISKYENGGMNASIEVAIKLEEILDV 180
PRK13355 PRK13355
bifunctional HTH-domain containing protein/aminotransferase; Provisional
 5-59 6.35e-04

bifunctional HTH-domain containing protein/aminotransferase; Provisional


Pssm-ID: 237361 [Multi-domain]  Cd Length: 517  Bit Score: 35.87  E-value: 6.35e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 499340629   5 TFSpDALRQIRRQRGVTQYKLAASLGVHN-----TAISHYENGHRRPDVETLATIADVLG 59
Cdd:PRK13355   3 TFA-ERLKQAMKARGLKQEDLVHAAEARGvklgkSHISQYVSGKTGPRRDVLPFLAAILG 61
MqsA_antitoxin pfam15731
Antitoxin component of bacterial toxin-antitoxin system, MqsA; MqsA_antitoxin is a family of ...
 8-46 2.09e-03

Antitoxin component of bacterial toxin-antitoxin system, MqsA; MqsA_antitoxin is a family of prokaryotic proteins that act as antidotes to the mRNA interferase MqsR. It has a zinc-binding at the very N-terminus indicating its DNA-binding capacity. MqsR is the gene most highly upregulated in E. Colo MqsR_toxin is a family of bacterial toxins that act as an mRNA interferase. MqsR is the gene most highly upregulated in E. coli persister cells and it plays an essential role in biofilm regulation and cell signalling. It forms part of a bacterial toxin-antitoxin TA system, and as expected for a TA system, the expression of the MqsR toxin leads to growth arrest, while co-expression with its antitoxin, MqsA, rescues the growth arrest phenotype. In addition, MqsR associates with MqsA to form a tight, non-toxic complex and both MqsA alone and the MqsR:MqsA2:MqsR complex bind and regulate the mqsR promoter. The structure of MqsR shows that is is a member of the RelE/YoeB family of bacterial RNases that are structurally and functionally characterized bacterial toxins.


Pssm-ID: 292359 [Multi-domain]  Cd Length: 131  Bit Score: 33.89  E-value: 2.09e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 499340629    8 PDALRQIRRQRGVTQYKLAASLGVHNTAISHYENGHRRP 46
Cdd:pfam15731  71 PAFIARVRKKLGLDQREAAEIFGGGVNAFSRYENGKTRP 109
RodZ COG1426
Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell ...
 11-59 9.25e-03

Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441035 [Multi-domain]  Cd Length: 71  Bit Score: 31.31  E-value: 9.25e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 499340629 11 LRQIRRQRGVTQYKLAASLGVHNTAISHYENGHRRPDVET------LATIADVLG 59
Cdd:COG1426  10 LRQAREAKGLSLEDVAERTKISVSYLEAIEEGDFDALPGPvyvrgfLRSYARALG 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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