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MULTISPECIES: helix-turn-helix transcriptional regulator [Streptomyces]
helix-turn-helix domain-containing protein( domain architecture ID 10650117)
helix-turn-helix (HTH) domain-containing protein with an XRE (Xenobiotic Response Element) family HTH domain, binds DNA and may function as a transcriptional regulator
List of domain hits
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Name | Accession | Description | Interval | E-value | ||
HTH_XRE | smart00530 | Helix-turn-helix XRE-family like proteins; |
11-65 | 3.06e-17 | ||
Helix-turn-helix XRE-family like proteins; : Pssm-ID: 197775 [Multi-domain] Cd Length: 56 Bit Score: 67.54 E-value: 3.06e-17
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Name | Accession | Description | Interval | E-value | ||
HTH_XRE | smart00530 | Helix-turn-helix XRE-family like proteins; |
11-65 | 3.06e-17 | ||
Helix-turn-helix XRE-family like proteins; Pssm-ID: 197775 [Multi-domain] Cd Length: 56 Bit Score: 67.54 E-value: 3.06e-17
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HTH_3 | pfam01381 | Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ... |
11-65 | 1.09e-16 | ||
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family. Pssm-ID: 460181 [Multi-domain] Cd Length: 55 Bit Score: 66.41 E-value: 1.09e-16
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HipB | COG1396 | Transcriptional regulator, contains XRE-family HTH domain [Transcription]; |
11-68 | 1.14e-16 | ||
Transcriptional regulator, contains XRE-family HTH domain [Transcription]; Pssm-ID: 441006 [Multi-domain] Cd Length: 83 Bit Score: 66.94 E-value: 1.14e-16
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HTH_XRE | cd00093 | Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ... |
9-65 | 1.87e-16 | ||
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators. Pssm-ID: 238045 [Multi-domain] Cd Length: 58 Bit Score: 65.65 E-value: 1.87e-16
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CxxCG_CxxCG_HTH | TIGR03830 | putative zinc finger/helix-turn-helix protein, YgiT family; This model describes a family of ... |
7-46 | 1.13e-07 | ||
putative zinc finger/helix-turn-helix protein, YgiT family; This model describes a family of predicted regulatory proteins with a conserved zinc finger/HTH architecture. The amino-terminal region contains a novel domain, featuring two CXXC motifs and occuring in a number of small bacterial proteins as well as in the present family. The carboxyl-terminal region consists of a helix-turn-helix domain, modeled by pfam01381. The predicted function is DNA binding and transcriptional regulation. Pssm-ID: 274805 [Multi-domain] Cd Length: 127 Bit Score: 44.93 E-value: 1.13e-07
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PRK09726 | PRK09726 | type II toxin-antitoxin system antitoxin HipB; |
6-60 | 1.17e-05 | ||
type II toxin-antitoxin system antitoxin HipB; Pssm-ID: 182049 Cd Length: 88 Bit Score: 39.19 E-value: 1.17e-05
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Name | Accession | Description | Interval | E-value | ||
HTH_XRE | smart00530 | Helix-turn-helix XRE-family like proteins; |
11-65 | 3.06e-17 | ||
Helix-turn-helix XRE-family like proteins; Pssm-ID: 197775 [Multi-domain] Cd Length: 56 Bit Score: 67.54 E-value: 3.06e-17
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HTH_3 | pfam01381 | Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ... |
11-65 | 1.09e-16 | ||
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family. Pssm-ID: 460181 [Multi-domain] Cd Length: 55 Bit Score: 66.41 E-value: 1.09e-16
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HipB | COG1396 | Transcriptional regulator, contains XRE-family HTH domain [Transcription]; |
11-68 | 1.14e-16 | ||
Transcriptional regulator, contains XRE-family HTH domain [Transcription]; Pssm-ID: 441006 [Multi-domain] Cd Length: 83 Bit Score: 66.94 E-value: 1.14e-16
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HTH_XRE | cd00093 | Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ... |
9-65 | 1.87e-16 | ||
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators. Pssm-ID: 238045 [Multi-domain] Cd Length: 58 Bit Score: 65.65 E-value: 1.87e-16
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XRE | COG1476 | DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription]; |
10-67 | 1.34e-14 | ||
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription]; Pssm-ID: 441085 [Multi-domain] Cd Length: 68 Bit Score: 61.40 E-value: 1.34e-14
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aMBF1 | COG1813 | Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and ... |
8-64 | 7.89e-12 | ||
Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis]; Pssm-ID: 441418 [Multi-domain] Cd Length: 70 Bit Score: 54.17 E-value: 7.89e-12
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AF2118 | COG3620 | Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain ... |
9-66 | 4.26e-10 | ||
Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain CBS pair) [Transcription]; Pssm-ID: 442838 [Multi-domain] Cd Length: 95 Bit Score: 50.79 E-value: 4.26e-10
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YiaG | COG2944 | DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription]; |
1-47 | 1.66e-09 | ||
DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription]; Pssm-ID: 442187 [Multi-domain] Cd Length: 64 Bit Score: 48.39 E-value: 1.66e-09
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HTH_19 | pfam12844 | Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. ... |
11-59 | 1.09e-08 | ||
Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. This family contains many example antitoxins from bacterial toxin-antitoxin systems. These antitoxins are likely to be DNA-binding domains. Pssm-ID: 463728 [Multi-domain] Cd Length: 64 Bit Score: 46.13 E-value: 1.09e-08
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CxxCG_CxxCG_HTH | TIGR03830 | putative zinc finger/helix-turn-helix protein, YgiT family; This model describes a family of ... |
7-46 | 1.13e-07 | ||
putative zinc finger/helix-turn-helix protein, YgiT family; This model describes a family of predicted regulatory proteins with a conserved zinc finger/HTH architecture. The amino-terminal region contains a novel domain, featuring two CXXC motifs and occuring in a number of small bacterial proteins as well as in the present family. The carboxyl-terminal region consists of a helix-turn-helix domain, modeled by pfam01381. The predicted function is DNA binding and transcriptional regulation. Pssm-ID: 274805 [Multi-domain] Cd Length: 127 Bit Score: 44.93 E-value: 1.13e-07
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couple_hipB | TIGR03070 | transcriptional regulator, y4mF family; Members of this family belong to a clade of ... |
9-62 | 7.63e-07 | ||
transcriptional regulator, y4mF family; Members of this family belong to a clade of helix-turn-helix DNA-binding proteins, among the larger family pfam01381 (HTH_3; Helix-turn-helix). Members are similar in sequence to the HipB protein of E. coli. Genes for members of the seed alignment for this protein family were found to be closely linked to genes encoding proteins related to HipA. The HibBA operon appears to have some features in common with toxin-antitoxin post-segregational killing systems. [Regulatory functions, DNA interactions] Pssm-ID: 213767 [Multi-domain] Cd Length: 58 Bit Score: 41.49 E-value: 7.63e-07
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VapI | COG3093 | Plasmid maintenance system antidote protein VapI, contains XRE-type HTH domain [Defense ... |
18-59 | 1.40e-06 | ||
Plasmid maintenance system antidote protein VapI, contains XRE-type HTH domain [Defense mechanisms]; Pssm-ID: 442327 [Multi-domain] Cd Length: 87 Bit Score: 41.33 E-value: 1.40e-06
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HTH_26 | pfam13443 | Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to ... |
11-67 | 2.21e-06 | ||
Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to DNA. Pssm-ID: 433211 [Multi-domain] Cd Length: 63 Bit Score: 40.22 E-value: 2.21e-06
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HTH_31 | pfam13560 | Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA. |
11-60 | 2.62e-06 | ||
Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA. Pssm-ID: 433309 [Multi-domain] Cd Length: 64 Bit Score: 40.20 E-value: 2.62e-06
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PRK09726 | PRK09726 | type II toxin-antitoxin system antitoxin HipB; |
6-60 | 1.17e-05 | ||
type II toxin-antitoxin system antitoxin HipB; Pssm-ID: 182049 Cd Length: 88 Bit Score: 39.19 E-value: 1.17e-05
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PRK09706 | PRK09706 | transcriptional repressor DicA; Reviewed |
1-58 | 1.87e-05 | ||
transcriptional repressor DicA; Reviewed Pssm-ID: 182039 [Multi-domain] Cd Length: 135 Bit Score: 39.45 E-value: 1.87e-05
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PRK09943 | PRK09943 | HTH-type transcriptional regulator PuuR; |
11-65 | 2.18e-05 | ||
HTH-type transcriptional regulator PuuR; Pssm-ID: 182158 [Multi-domain] Cd Length: 185 Bit Score: 39.78 E-value: 2.18e-05
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PHA01976 | PHA01976 | helix-turn-helix protein |
8-63 | 4.50e-05 | ||
helix-turn-helix protein Pssm-ID: 177330 [Multi-domain] Cd Length: 67 Bit Score: 37.24 E-value: 4.50e-05
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COG1395 | COG1395 | Predicted transcriptional regulator [Transcription]; |
8-60 | 5.43e-05 | ||
Predicted transcriptional regulator [Transcription]; Pssm-ID: 441005 [Multi-domain] Cd Length: 313 Bit Score: 38.66 E-value: 5.43e-05
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PRK04140 | PRK04140 | transcriptional regulator; |
9-60 | 2.16e-04 | ||
transcriptional regulator; Pssm-ID: 235224 [Multi-domain] Cd Length: 317 Bit Score: 37.14 E-value: 2.16e-04
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PRK13355 | PRK13355 | bifunctional HTH-domain containing protein/aminotransferase; Provisional |
5-59 | 6.35e-04 | ||
bifunctional HTH-domain containing protein/aminotransferase; Provisional Pssm-ID: 237361 [Multi-domain] Cd Length: 517 Bit Score: 35.87 E-value: 6.35e-04
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MqsA_antitoxin | pfam15731 | Antitoxin component of bacterial toxin-antitoxin system, MqsA; MqsA_antitoxin is a family of ... |
8-46 | 2.09e-03 | ||
Antitoxin component of bacterial toxin-antitoxin system, MqsA; MqsA_antitoxin is a family of prokaryotic proteins that act as antidotes to the mRNA interferase MqsR. It has a zinc-binding at the very N-terminus indicating its DNA-binding capacity. MqsR is the gene most highly upregulated in E. Colo MqsR_toxin is a family of bacterial toxins that act as an mRNA interferase. MqsR is the gene most highly upregulated in E. coli persister cells and it plays an essential role in biofilm regulation and cell signalling. It forms part of a bacterial toxin-antitoxin TA system, and as expected for a TA system, the expression of the MqsR toxin leads to growth arrest, while co-expression with its antitoxin, MqsA, rescues the growth arrest phenotype. In addition, MqsR associates with MqsA to form a tight, non-toxic complex and both MqsA alone and the MqsR:MqsA2:MqsR complex bind and regulate the mqsR promoter. The structure of MqsR shows that is is a member of the RelE/YoeB family of bacterial RNases that are structurally and functionally characterized bacterial toxins. Pssm-ID: 292359 [Multi-domain] Cd Length: 131 Bit Score: 33.89 E-value: 2.09e-03
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RodZ | COG1426 | Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell ... |
11-59 | 9.25e-03 | ||
Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell division, chromosome partitioning]; Pssm-ID: 441035 [Multi-domain] Cd Length: 71 Bit Score: 31.31 E-value: 9.25e-03
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