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Conserved domains on  [gi|499338777|ref|WP_011028485|]
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MULTISPECIES: bifunctional 2-polyprenyl-6-hydroxyphenol methylase/3-demethylubiquinol 3-O-methyltransferase UbiG [Streptomyces]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 11454890)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

EC:  2.1.1.-
Gene Ontology:  GO:0032259|GO:0008168|GO:1904047
PubMed:  12504684|12826405

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 19-138 3.69e-21

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


:

Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 85.07  E-value: 3.69e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499338777  19 NAAHPWDhnAHYHRWILRQLPRRfGSALDVGSGTGDLARLLATRADEVRGVDSDPAITAQARALTPEpTAASFAVADALT 98
Cdd:COG2227    5 DARDFWD--RRLAALLARLLPAG-GRVLDVGCGTGRLALALARRGADVTGVDISPEALEIARERAAE-LNVDFVQGDLED 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 499338777  99 -DLPAGPHDVITCVATLHHLP-FTEALDTFREHMAPGGILVV 138
Cdd:COG2227   81 lPLEDGSFDLVICSEVLEHLPdPAALLRELARLLKPGGLLLL 122
 
Name Accession Description Interval E-value
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 19-138 3.69e-21

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 85.07  E-value: 3.69e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499338777  19 NAAHPWDhnAHYHRWILRQLPRRfGSALDVGSGTGDLARLLATRADEVRGVDSDPAITAQARALTPEpTAASFAVADALT 98
Cdd:COG2227    5 DARDFWD--RRLAALLARLLPAG-GRVLDVGCGTGRLALALARRGADVTGVDISPEALEIARERAAE-LNVDFVQGDLED 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 499338777  99 -DLPAGPHDVITCVATLHHLP-FTEALDTFREHMAPGGILVV 138
Cdd:COG2227   81 lPLEDGSFDLVICSEVLEHLPdPAALLRELARLLKPGGLLLL 122
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 46-134 4.42e-15

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 67.97  E-value: 4.42e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499338777   46 LDVGSGTGDLARLLATRAD-EVRGVDSDPAITAQARA-LTPEPTAASFAVADALT-DLPAGPHDVITCVATLHHLPFTEA 122
Cdd:pfam13649   2 LDLGCGTGRLTLALARRGGaRVTGVDLSPEMLERARErAAEAGLNVEFVQGDAEDlPFPDGSFDLVVSSGVLHHLPDPDL 81

                          90
                  ....*....|....*
gi 499338777  123 LDTFRE---HMAPGG 134
Cdd:pfam13649  82 EAALREiarVLKPGG 96
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 46-139 2.81e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 55.51  E-value: 2.81e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499338777  46 LDVGSGTGDLARLLATR-ADEVRGVDSDPAI--TAQARALTPEPTAASFAVADALTDLPA--GPHDVITCVATLHHLPFT 120
Cdd:cd02440    3 LDLGCGTGALALALASGpGARVTGVDISPVAleLARKAAAALLADNVEVLKGDAEELPPEadESFDVIISDPPLHHLVED 82

                         90       100
                 ....*....|....*....|.
gi 499338777 121 --EALDTFREHMAPGGILVVV 139
Cdd:cd02440   83 laRFLEEARRLLKPGGVLVLT 103
PRK06202 PRK06202
hypothetical protein; Provisional
 1-221 3.25e-09

hypothetical protein; Provisional


Pssm-ID: 180466 [Multi-domain]  Cd Length: 232  Bit Score: 55.01  E-value: 3.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499338777   1 MTLAGLTPHRLVQALDRF---NAAHPWDHNAHYHRWILRQLPRRFGSALDVGSGTGDLARLLATRAD------EVRGVDS 71
Cdd:PRK06202  17 MDDPGCDPARLDRTYAGFrrvNRIVAGWRGLYRRLLRPALSADRPLTLLDIGCGGGDLAIDLARWARrdglrlEVTAIDP 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499338777  72 DPAITAQARALTPEPTAA-SFAVADALTDLPAGpHDVITCVATLHHLPfTEALDTFREHMApggilvvvGLYRPRTVTDH 150
Cdd:PRK06202  97 DPRAVAFARANPRRPGVTfRQAVSDELVAEGER-FDVVTSNHFLHHLD-DAEVVRLLADSA--------ALARRLVLHND 166

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 499338777 151 LL-GAGAVLPNAALGWLKNRGRAAAP--PTSMTARTRPADMafpdiaaeAHTVLPGARLRRRLFWRYTLTWRRP 221
Cdd:PRK06202 167 LIrSRLAYALFWAGTRLLSRSSFVHTdgLLSVRRSYTPAEL--------AALAPQGWRVERQWPFRYLLVWDPH 232
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 32-146 9.57e-08

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 50.72  E-value: 9.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499338777   32 RWILRQLPRRFgsaLDVGSGTGDLARLLATRA---DEVRGVDSDPAITAQARALTPEPTAASFAVADALtDLPAGPH--D 106
Cdd:TIGR01934  33 KLIGVFKGQKV---LDVACGTGDLAIELAKSApdrGKVTGVDFSSEMLEVAKKKSELPLNIEFIQADAE-ALPFEDNsfD 108

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 499338777  107 VITCVATLHHLP-FTEALDTFREHMAPGGILVVVGLYRPRT 146
Cdd:TIGR01934 109 AVTIAFGLRNVTdIQKALREMYRVLKPGGRLVILEFSKPAN 149
 
Name Accession Description Interval E-value
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 19-138 3.69e-21

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 85.07  E-value: 3.69e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499338777  19 NAAHPWDhnAHYHRWILRQLPRRfGSALDVGSGTGDLARLLATRADEVRGVDSDPAITAQARALTPEpTAASFAVADALT 98
Cdd:COG2227    5 DARDFWD--RRLAALLARLLPAG-GRVLDVGCGTGRLALALARRGADVTGVDISPEALEIARERAAE-LNVDFVQGDLED 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 499338777  99 -DLPAGPHDVITCVATLHHLP-FTEALDTFREHMAPGGILVV 138
Cdd:COG2227   81 lPLEDGSFDLVICSEVLEHLPdPAALLRELARLLKPGGLLLL 122
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
41-139 1.51e-19

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 79.87  E-value: 1.51e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499338777  41 RFGSALDVGSGTGDLARLLATRADEVR--GVDSDPAITAQARALTPEptaASFAVADALTDLPAGPHDVITCVATLHHLP 118
Cdd:COG4106    1 PPRRVLDLGCGTGRLTALLAERFPGARvtGVDLSPEMLARARARLPN---VRFVVADLRDLDPPEPFDLVVSNAALHWLP 77

                         90       100
                 ....*....|....*....|..
gi 499338777 119 -FTEALDTFREHMAPGGILVVV 139
Cdd:COG4106   78 dHAALLARLAAALAPGGVLAVQ 99
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 24-155 4.22e-18

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 77.34  E-value: 4.22e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499338777  24 WDHNAHY---HRWILRQLPRRFGS-ALDVGSGTGDLARLLATRADEVRGVDSDPAITAQARALTPE-PTAASFAVADAL- 97
Cdd:COG2226    1 FDRVAARydgREALLAALGLRPGArVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAEaGLNVEFVVGDAEd 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499338777  98 TDLPAGPHDVITCVATLHHLP-FTEALDTFREHMAPGGILVVVGLYRP--RTVTDHLLGAG 155
Cdd:COG2226   81 LPFPDGSFDLVISSFVLHHLPdPERALAEIARVLKPGGRLVVVDFSPPdlAELEELLAEAG 141
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 46-134 4.42e-15

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 67.97  E-value: 4.42e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499338777   46 LDVGSGTGDLARLLATRAD-EVRGVDSDPAITAQARA-LTPEPTAASFAVADALT-DLPAGPHDVITCVATLHHLPFTEA 122
Cdd:pfam13649   2 LDLGCGTGRLTLALARRGGaRVTGVDLSPEMLERARErAAEAGLNVEFVQGDAEDlPFPDGSFDLVVSSGVLHHLPDPDL 81

                          90
                  ....*....|....*
gi 499338777  123 LDTFRE---HMAPGG 134
Cdd:pfam13649  82 EAALREiarVLKPGG 96
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
28-137 1.03e-14

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 69.26  E-value: 1.03e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499338777  28 AHYHRWILRQLP-RRFGSALDVGSGTGDLARLLATRADEVRGVDSDPAITAQARAltpEPTAASFAVADaLTDLPAGPH- 105
Cdd:COG4976   32 ALLAEELLARLPpGPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKARE---KGVYDRLLVAD-LADLAEPDGr 107

                         90       100       110
                 ....*....|....*....|....*....|....
gi 499338777 106 -DVITCVATLHHLP-FTEALDTFREHMAPGGILV 137
Cdd:COG4976  108 fDLIVAADVLTYLGdLAAVFAGVARALKPGGLFI 141
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 34-198 1.62e-12

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 63.78  E-value: 1.62e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499338777  34 ILRQLPRRfGSALDVGSGTGDLARLLATRA-DEVRGVDSDPAITAQARALTPEPTAAS--FAVADA--LTDLPAGPHDVI 108
Cdd:COG0500   20 LLERLPKG-GRVLDLGCGTGRNLLALAARFgGRVIGIDLSPEAIALARARAAKAGLGNveFLVADLaeLDPLPAESFDLV 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499338777 109 TCVATLHHLPFTEALDTFRE---HMAPGGILVVVGLYRPRTVTD--HLLGAGAVLPNAALGWLKNRGRAAAPPTSMTART 183
Cdd:COG0500   99 VAFGVLHHLPPEEREALLRElarALKPGGVLLLSASDAAAALSLarLLLLATASLLELLLLLRLLALELYLRALLAAAAT 178

                        170
                 ....*....|....*
gi 499338777 184 RPADMAFPDIAAEAH 198
Cdd:COG0500  179 EDLRSDALLESANAL 193
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 46-138 1.01e-11

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 59.22  E-value: 1.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499338777   46 LDVGSGTGDLARLLATRADEVRGVDSDPAITAQARALTPEPtAASFAVADAlTDLPAGPH--DVITCVATLHHLPFTEAL 123
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKAPRE-GLTFVVGDA-EDLPFPDNsfDLVLSSEVLHHVEDPERA 78

                          90
                  ....*....|....*...
gi 499338777  124 dtFRE---HMAPGGILVV 138
Cdd:pfam08241  79 --LREiarVLKPGGILII 94
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 32-138 2.14e-11

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 60.13  E-value: 2.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499338777   32 RWILRQLPRRF--GSALDVGSGTGDLARLLATRADEVRGVDSDPAITAQARaltpePTAASFAVADALTDLPAGPHDVIT 109
Cdd:pfam13489  11 DLLLRLLPKLPspGRVLDFGCGTGIFLRLLRAQGFSVTGVDPSPIAIERAL-----LNVRFDQFDEQEAAVPAGKFDVIV 85

                          90       100       110
                  ....*....|....*....|....*....|
gi 499338777  110 CVATLHHLP-FTEALDTFREHMAPGGILVV 138
Cdd:pfam13489  86 AREVLEHVPdPPALLRQIAALLKPGGLLLL 115
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 32-138 1.14e-10

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 58.02  E-value: 1.14e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499338777  32 RWILRQLPRRFGS-ALDVGSGTGDLARLLATRAD-EVRGVDSDPAITAQARALTPE---PTAASFAVADALTDLPAGPHD 106
Cdd:COG2230   41 DLILRKLGLKPGMrVLDIGCGWGGLALYLARRYGvRVTGVTLSPEQLEYARERAAEaglADRVEVRLADYRDLPADGQFD 120

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 499338777 107 VITCVATLHHLP---FTEALDTFREHMAPGGILVV 138
Cdd:COG2230  121 AIVSIGMFEHVGpenYPAYFAKVARLLKPGGRLLL 155
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 46-139 2.81e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 55.51  E-value: 2.81e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499338777  46 LDVGSGTGDLARLLATR-ADEVRGVDSDPAI--TAQARALTPEPTAASFAVADALTDLPA--GPHDVITCVATLHHLPFT 120
Cdd:cd02440    3 LDLGCGTGALALALASGpGARVTGVDISPVAleLARKAAAALLADNVEVLKGDAEELPPEadESFDVIISDPPLHHLVED 82

                         90       100
                 ....*....|....*....|.
gi 499338777 121 --EALDTFREHMAPGGILVVV 139
Cdd:cd02440   83 laRFLEEARRLLKPGGVLVLT 103
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 46-136 9.61e-10

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 53.91  E-value: 9.61e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499338777   46 LDVGSGTGDLARLLATRAD--EVRGVDSDPAITAQARALTPEPTAASFAVADA----LTDLPAGPHDVITCVATLHHLP- 118
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPglEYTGLDISPAALEAARERLAALGLLNAVRVELfqldLGELDPGSFDVVVASNVLHHLAd 80

                          90
                  ....*....|....*...
gi 499338777  119 FTEALDTFREHMAPGGIL 136
Cdd:pfam08242  81 PRAVLRNIRRLLKPGGVL 98
PRK06202 PRK06202
hypothetical protein; Provisional
 1-221 3.25e-09

hypothetical protein; Provisional


Pssm-ID: 180466 [Multi-domain]  Cd Length: 232  Bit Score: 55.01  E-value: 3.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499338777   1 MTLAGLTPHRLVQALDRF---NAAHPWDHNAHYHRWILRQLPRRFGSALDVGSGTGDLARLLATRAD------EVRGVDS 71
Cdd:PRK06202  17 MDDPGCDPARLDRTYAGFrrvNRIVAGWRGLYRRLLRPALSADRPLTLLDIGCGGGDLAIDLARWARrdglrlEVTAIDP 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499338777  72 DPAITAQARALTPEPTAA-SFAVADALTDLPAGpHDVITCVATLHHLPfTEALDTFREHMApggilvvvGLYRPRTVTDH 150
Cdd:PRK06202  97 DPRAVAFARANPRRPGVTfRQAVSDELVAEGER-FDVVTSNHFLHHLD-DAEVVRLLADSA--------ALARRLVLHND 166

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 499338777 151 LL-GAGAVLPNAALGWLKNRGRAAAP--PTSMTARTRPADMafpdiaaeAHTVLPGARLRRRLFWRYTLTWRRP 221
Cdd:PRK06202 167 LIrSRLAYALFWAGTRLLSRSSFVHTdgLLSVRRSYTPAEL--------AALAPQGWRVERQWPFRYLLVWDPH 232
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 32-146 9.57e-08

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 50.72  E-value: 9.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499338777   32 RWILRQLPRRFgsaLDVGSGTGDLARLLATRA---DEVRGVDSDPAITAQARALTPEPTAASFAVADALtDLPAGPH--D 106
Cdd:TIGR01934  33 KLIGVFKGQKV---LDVACGTGDLAIELAKSApdrGKVTGVDFSSEMLEVAKKKSELPLNIEFIQADAE-ALPFEDNsfD 108

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 499338777  107 VITCVATLHHLP-FTEALDTFREHMAPGGILVVVGLYRPRT 146
Cdd:TIGR01934 109 AVTIAFGLRNVTdIQKALREMYRVLKPGGRLVILEFSKPAN 149
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 46-139 1.05e-07

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 50.47  E-value: 1.05e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499338777  46 LDVGSGTGDLARLLATRADEVRGVDSDPAITAQARALTPE--PTAASFAVADALTDLPA-GPHDVITCVATLHHLPftea 122
Cdd:COG2518   71 LEIGTGSGYQAAVLARLAGRVYSVERDPELAERARERLAAlgYDNVTVRVGDGALGWPEhAPFDRIIVTAAAPEVP---- 146

                         90
                 ....*....|....*..
gi 499338777 123 lDTFREHMAPGGILVVV 139
Cdd:COG2518  147 -EALLEQLAPGGRLVAP 162
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 46-138 3.21e-07

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 48.18  E-value: 3.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499338777   46 LDVGSGTGDLARLLATRAD---EVRGVDSDPAITAQARALTPE--PTAASFAVADAL---TDLPAGPHDVITCVATLHHL 117
Cdd:pfam13847   8 LDLGCGTGHLSFELAEELGpnaEVVGIDISEEAIEKARENAQKlgFDNVEFEQGDIEelpELLEDDKFDVVISNCVLNHI 87

                          90       100
                  ....*....|....*....|..
gi 499338777  118 PFT-EALDTFREHMAPGGILVV 138
Cdd:pfam13847  88 PDPdKVLQEILRVLKPGGRLII 109
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 35-140 1.30e-06

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 47.11  E-value: 1.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499338777  35 LRQLPRRF-GSALDVGSGTGDLARLLATRADEVR--GVDSDP-AIT-AQARALTPEPTAASFAVADALTDLPAGPHDVIT 109
Cdd:COG2813   42 LEHLPEPLgGRVLDLGCGYGVIGLALAKRNPEARvtLVDVNArAVElARANAAANGLENVEVLWSDGLSGVPDGSFDLIL 121

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 499338777 110 C-----------VATLHHLpFTEAldtfREHMAPGGILVVVG 140
Cdd:COG2813  122 SnppfhagravdKEVAHAL-IADA----ARHLRPGGELWLVA 158
DUF938 pfam06080
Protein of unknown function (DUF938); This family consists of several hypothetical proteins ...
 34-143 7.10e-06

Protein of unknown function (DUF938); This family consists of several hypothetical proteins from both prokaryotes and eukaryotes. The function of this family is unknown.


Pssm-ID: 253548  Cd Length: 201  Bit Score: 45.14  E-value: 7.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499338777   34 ILRQLPRRFGSALDVGSGTGDLARLLATRADEVRGVDSDPA------ITAQARAL----TPEPTA--ASFAVADALTDLP 101
Cdd:pfam06080  18 LQSYFAKTTERVLEIASGTGQHAVFFAPLLPNLTWQPSDPDpnlrgsIAAWADQQglrnLRPPLHldVTRPPWPVEAPAP 97

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 499338777  102 AgPHDVITCVATLHHLPFTEALDTFR---EHMAPGGILVVVGLYR 143
Cdd:pfam06080  98 A-SYDAIFSINMIHISPWSCVEGLFRgagRLLPPGGVLYIYGPYN 141
PRK08317 PRK08317
hypothetical protein; Provisional
 30-139 2.27e-05

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 43.77  E-value: 2.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499338777  30 YHRWILRQL-PRRFGSALDVGSGTGDLARLLATR---ADEVRGVDSDPAITAQAR-ALTPEPTAASF--AVADALtDLPA 102
Cdd:PRK08317   7 YRARTFELLaVQPGDRVLDVGCGPGNDARELARRvgpEGRVVGIDRSEAMLALAKeRAAGLGPNVEFvrGDADGL-PFPD 85

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 499338777 103 GPHDVITCVATLHHLPFTE-ALDTFREHMAPGGILVVV 139
Cdd:PRK08317  86 GSFDAVRSDRVLQHLEDPArALAEIARVLRPGGRVVVL 123
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
32-142 5.09e-05

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 43.24  E-value: 5.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499338777  32 RWILRQLPRRfGSALDVGSGTGDLArLLATR--ADEVRGVDSDP-AITAqAR---ALTPEPTAASFAVADAltdLPAGPH 105
Cdd:COG2264  140 EALEKLLKPG-KTVLDVGCGSGILA-IAAAKlgAKRVLAVDIDPvAVEA-ARenaELNGVEDRIEVVLGDL---LEDGPY 213

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 499338777 106 DVItcVATLHHLPFTEALDTFREHMAPGGILVVVGLY 142
Cdd:COG2264  214 DLV--VANILANPLIELAPDLAALLKPGGYLILSGIL 248
PRK01683 PRK01683
trans-aconitate 2-methyltransferase; Provisional
 45-138 8.78e-05

trans-aconitate 2-methyltransferase; Provisional


Pssm-ID: 234970  Cd Length: 258  Bit Score: 42.24  E-value: 8.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499338777  45 ALDVGSGTGDLARLLATR--ADEVRGVDSDPAITAQARALTPEptaASFAVADALTDLPAGPHDVITCVATLHHLPftEA 122
Cdd:PRK01683  35 VVDLGCGPGNSTELLVERwpAARITGIDSSPAMLAEARSRLPD---CQFVEADIASWQPPQALDLIFANASLQWLP--DH 109

                         90
                 ....*....|....*....
gi 499338777 123 LDTFREHM---APGGILVV 138
Cdd:PRK01683 110 LELFPRLVsllAPGGVLAV 128
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 35-141 4.17e-04

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 40.33  E-value: 4.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499338777   35 LRQLPRRFGSALDVGSGTGDL---ARLLAtrADEVRGVDSDP-AITAQARALTPEPTAASFAVAdALTDLPAGPHDVItc 110
Cdd:pfam06325 155 LERLVKPGESVLDVGCGSGILaiaALKLG--AKKVVGVDIDPvAVRAAKENAELNGVEARLEVY-LPGDLPKEKADVV-- 229

                          90       100       110
                  ....*....|....*....|....*....|.
gi 499338777  111 VATLHHLPFTEALDTFREHMAPGGILVVVGL 141
Cdd:pfam06325 230 VANILADPLIELAPDIYALVKPGGYLILSGI 260
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 39-140 4.39e-04

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 39.50  E-value: 4.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499338777   39 PRRFGSALDVGSGTGDLARLLATRADEVR--GVDSDPAITAQAR--ALTPEPTAASFAVADALTDLPAGPHDVITCvatl 114
Cdd:pfam05175  29 KDLSGKVLDLGCGAGVLGAALAKESPDAEltMVDINARALESARenLAANGLENGEVVASDVYSGVEDGKFDLIIS---- 104

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 499338777  115 hHLPFTEALDTF-----------REHMAPGGILVVVG 140
Cdd:pfam05175 105 -NPPFHAGLATTynvaqrfiadaKRHLRPGGELWIVA 140
PRK14103 PRK14103
trans-aconitate 2-methyltransferase; Provisional
 39-138 6.87e-04

trans-aconitate 2-methyltransferase; Provisional


Pssm-ID: 184509  Cd Length: 255  Bit Score: 39.67  E-value: 6.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499338777  39 PRRfgsALDVGSGTGDLARLLATRADE--VRGVDSDPAITAQARaltpePTAASFAVADALTDLPAGPHDVITCVATLHH 116
Cdd:PRK14103  30 ARR---VVDLGCGPGNLTRYLARRWPGavIEALDSSPEMVAAAR-----ERGVDARTGDVRDWKPKPDTDVVVSNAALQW 101

                         90       100
                 ....*....|....*....|....*
gi 499338777 117 LPftEALDTFR---EHMAPGGILVV 138
Cdd:PRK14103 102 VP--EHADLLVrwvDELAPGSWIAV 124
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
32-142 2.68e-03

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 37.82  E-value: 2.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499338777  32 RWILRQLPRRfGSALDVGSGTGDL---ARLLAtrADEVRGVDSDP-AITAqaraltpepTAASFA---VADALTdLPAG- 103
Cdd:PRK00517 111 EALEKLVLPG-KTVLDVGCGSGILaiaAAKLG--AKKVLAVDIDPqAVEA---------ARENAElngVELNVY-LPQGd 177

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 499338777 104 -PHDVITC--VATLHhlpftEAL-DTFREHMAPGGILVVVGLY 142
Cdd:PRK00517 178 lKADVIVAniLANPL-----LELaPDLARLLKPGGRLILSGIL 215
PLN02585 PLN02585
magnesium protoporphyrin IX methyltransferase
 47-131 3.90e-03

magnesium protoporphyrin IX methyltransferase


Pssm-ID: 215319 [Multi-domain]  Cd Length: 315  Bit Score: 37.53  E-value: 3.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499338777  47 DVGSGTGDLARLLATRADEVRGVDSDPAITAQAR-------ALTPEPTAASFAVADaLTDLpAGPHDVITCVATLHHLPf 119
Cdd:PLN02585 150 DAGCGTGSLAIPLALEGAIVSASDISAAMVAEAErrakealAALPPEVLPKFEAND-LESL-SGKYDTVTCLDVLIHYP- 226

                         90
                 ....*....|..
gi 499338777 120 TEALDTFREHMA 131
Cdd:PLN02585 227 QDKADGMIAHLA 238
PRK14968 PRK14968
putative methyltransferase; Provisional
 43-80 4.14e-03

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 36.80  E-value: 4.14e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 499338777  43 GSALDVGSGTGDLARLLATRADEVRGVDSDPAITAQAR 80
Cdd:PRK14968  25 DRVLEVGTGSGIVAIVAAKNGKKVVGVDINPYAVECAK 62
YtxK COG0827
Adenine-specific DNA N6-methylase [Replication, recombination and repair];
46-110 7.97e-03

Adenine-specific DNA N6-methylase [Replication, recombination and repair];


Pssm-ID: 440589 [Multi-domain]  Cd Length: 327  Bit Score: 36.47  E-value: 7.97e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 499338777  46 LDVGSGTGDLAR-LLATRADEVR--GVDSDPAITAQARALTPE-PTAASFAVADALTDLPAGPHDVITC 110
Cdd:COG0827  120 LDPAVGTGNLLTtVLNQLKKKVNayGVEVDDLLIRLAAVLANLqGHPVELFHQDALQPLLIDPVDVVIS 188
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 45-101 8.48e-03

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 36.28  E-value: 8.48e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 499338777  45 ALDVGSGTGDLARLLATRAD---EVRGVDSDPAITAQARALTPEPTAA---SFAVADAlTDLP 101
Cdd:PRK00216  55 VLDLACGTGDLAIALAKAVGktgEVVGLDFSEGMLAVGREKLRDLGLSgnvEFVQGDA-EALP 116
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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