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Conserved domains on  [gi|499176622|ref|WP_010874209|]
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MULTISPECIES: type II CAAX prenyl endopeptidase Rce1 family protein [unclassified Synechocystis]

Protein Classification

COG4449 family protein( domain architecture ID 10008561)

COG4449 family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4449 COG4449
Predicted protease, Abi (CAAX) family [General function prediction only];
651-826 7.67e-63

Predicted protease, Abi (CAAX) family [General function prediction only];


:

Pssm-ID: 443548  Cd Length: 176  Bit Score: 209.10  E-value: 7.67e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499176622 651 PVLSALARRILAAIVFLPRPQDWQFFGIAVVVYGAIAMTLGFKFGLLQWQWWGQSLGGSMKSILALFFLPALGEELVFRV 730
Cdd:COG4449    1 PLLSLILSRLLRAVRTLPSLRDWLVALLILLIYAAIALPLGFITGFLQWSPWAASPLSLLAVILILLLFPAIGEELLFRG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499176622 731 MLLPYPTELNLFWPTLGAMLLSLVLFLLYHPLNALLFYPRGRNVFFQPIFLGLTGLLAVATTAIYWHSGSLWLIAIFHWL 810
Cdd:COG4449   81 LLLPHPVELASGLNWWLWILLSLVLFVLYHPLNALTFYPAGRPTFLNPRFLLLAGLLGLACTIAYLLTGSLWPAVIIHWL 160

                        170
                 ....*....|....*.
gi 499176622 811 VVVTWLMLLGGYGKLA 826
Cdd:COG4449  161 VVVVWLLLLGGYEKLL 176
Laminin_I super family cl26988
Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from ...
 452-574 1.99e-04

Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.


The actual alignment was detected with superfamily member pfam06008:

Pssm-ID: 310534 [Multi-domain]  Cd Length: 258  Bit Score: 43.94  E-value: 1.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499176622  452 VKLDVLEDYNfgGSVLSPLDELQKQLQIMMARYRTgdgtgyagVSPAASCVQDSNQALYLAIVGLQQKVQNSPEIITWLA 531
Cdd:pfam06008  40 IQIEILEKEL--SSLAQETEELQKKATQTLAKAQQ--------VNAESERTLGHAKELAEAIKNLIDNIKEINEKVATLG 109

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 499176622  532 QHGNSPENQRFQRLQQLGDRLLTMLKPRGITREDwQNNAATLA 574
Cdd:pfam06008 110 ENDFALPSSDLSRMLAEAQRMLGEIRSRDFGTQL-QNAEAELK 151
 
Name Accession Description Interval E-value
COG4449 COG4449
Predicted protease, Abi (CAAX) family [General function prediction only];
651-826 7.67e-63

Predicted protease, Abi (CAAX) family [General function prediction only];


Pssm-ID: 443548  Cd Length: 176  Bit Score: 209.10  E-value: 7.67e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499176622 651 PVLSALARRILAAIVFLPRPQDWQFFGIAVVVYGAIAMTLGFKFGLLQWQWWGQSLGGSMKSILALFFLPALGEELVFRV 730
Cdd:COG4449    1 PLLSLILSRLLRAVRTLPSLRDWLVALLILLIYAAIALPLGFITGFLQWSPWAASPLSLLAVILILLLFPAIGEELLFRG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499176622 731 MLLPYPTELNLFWPTLGAMLLSLVLFLLYHPLNALLFYPRGRNVFFQPIFLGLTGLLAVATTAIYWHSGSLWLIAIFHWL 810
Cdd:COG4449   81 LLLPHPVELASGLNWWLWILLSLVLFVLYHPLNALTFYPAGRPTFLNPRFLLLAGLLGLACTIAYLLTGSLWPAVIIHWL 160

                        170
                 ....*....|....*.
gi 499176622 811 VVVTWLMLLGGYGKLA 826
Cdd:COG4449  161 VVVVWLLLLGGYEKLL 176
Rce1-like pfam02517
Type II CAAX prenyl endopeptidase Rce1-like; This family (also known as the ABI (abortive ...
 713-811 1.07e-06

Type II CAAX prenyl endopeptidase Rce1-like; This family (also known as the ABI (abortive infection) family) contains putative IMPs and has homologs in all three domains of life, including Rce1 from S. cerevisiae. Rce1 is a type II CAAX prenyl protease that processes all farnesylated and geranylgeranylated CAAX proteins. It is an integral membrane endoprotease localized to the endoplasmic reticulum that mediates the cleavage of the carboxyl-terminal three amino acids from CaaX proteins. It is involved in processing the Ras family of small GTPases, the gamma-subunit of heterotrimeric GTPases, nuclear lamins, and protein kinases and phosphatases. Three residues of S. cerevisiae Rce1 -E156, H194 and H248- are critical for catalysis. The structure of Rce1 from the archaea Methanococcus (MmRce1) suggests that this group of proteins represents a novel IMP (intramembrane protease) family, the glutamate IMPs. There is a conserved sequence motif EExxxR.


Pssm-ID: 460578 [Multi-domain]  Cd Length: 92  Bit Score: 47.55  E-value: 1.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499176622  713 ILALFFLPALGEELVFRVMLLPYPTELnlFWPTLGAMllslvlfllyhpLNALLF----YPrgrnvfFQPIFLGLTGLLA 788
Cdd:pfam02517   7 LLLLALLAPIGEELLFRGYLLPRLRRR--LWPVLAIL------------ISSLLFglahLP------NGPQLFLLAFLLG 66

                          90       100
                  ....*....|....*....|...
gi 499176622  789 VATTAIYWHSGSLWLIAIFHWLV 811
Cdd:pfam02517  67 LILGYLYLRTGSLWAAILLHALN 89
Laminin_I pfam06008
Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from ...
 452-574 1.99e-04

Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.


Pssm-ID: 310534 [Multi-domain]  Cd Length: 258  Bit Score: 43.94  E-value: 1.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499176622  452 VKLDVLEDYNfgGSVLSPLDELQKQLQIMMARYRTgdgtgyagVSPAASCVQDSNQALYLAIVGLQQKVQNSPEIITWLA 531
Cdd:pfam06008  40 IQIEILEKEL--SSLAQETEELQKKATQTLAKAQQ--------VNAESERTLGHAKELAEAIKNLIDNIKEINEKVATLG 109

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 499176622  532 QHGNSPENQRFQRLQQLGDRLLTMLKPRGITREDwQNNAATLA 574
Cdd:pfam06008 110 ENDFALPSSDLSRMLAEAQRMLGEIRSRDFGTQL-QNAEAELK 151
 
Name Accession Description Interval E-value
COG4449 COG4449
Predicted protease, Abi (CAAX) family [General function prediction only];
651-826 7.67e-63

Predicted protease, Abi (CAAX) family [General function prediction only];


Pssm-ID: 443548  Cd Length: 176  Bit Score: 209.10  E-value: 7.67e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499176622 651 PVLSALARRILAAIVFLPRPQDWQFFGIAVVVYGAIAMTLGFKFGLLQWQWWGQSLGGSMKSILALFFLPALGEELVFRV 730
Cdd:COG4449    1 PLLSLILSRLLRAVRTLPSLRDWLVALLILLIYAAIALPLGFITGFLQWSPWAASPLSLLAVILILLLFPAIGEELLFRG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499176622 731 MLLPYPTELNLFWPTLGAMLLSLVLFLLYHPLNALLFYPRGRNVFFQPIFLGLTGLLAVATTAIYWHSGSLWLIAIFHWL 810
Cdd:COG4449   81 LLLPHPVELASGLNWWLWILLSLVLFVLYHPLNALTFYPAGRPTFLNPRFLLLAGLLGLACTIAYLLTGSLWPAVIIHWL 160

                        170
                 ....*....|....*.
gi 499176622 811 VVVTWLMLLGGYGKLA 826
Cdd:COG4449  161 VVVVWLLLLGGYEKLL 176
Rce1-like pfam02517
Type II CAAX prenyl endopeptidase Rce1-like; This family (also known as the ABI (abortive ...
 713-811 1.07e-06

Type II CAAX prenyl endopeptidase Rce1-like; This family (also known as the ABI (abortive infection) family) contains putative IMPs and has homologs in all three domains of life, including Rce1 from S. cerevisiae. Rce1 is a type II CAAX prenyl protease that processes all farnesylated and geranylgeranylated CAAX proteins. It is an integral membrane endoprotease localized to the endoplasmic reticulum that mediates the cleavage of the carboxyl-terminal three amino acids from CaaX proteins. It is involved in processing the Ras family of small GTPases, the gamma-subunit of heterotrimeric GTPases, nuclear lamins, and protein kinases and phosphatases. Three residues of S. cerevisiae Rce1 -E156, H194 and H248- are critical for catalysis. The structure of Rce1 from the archaea Methanococcus (MmRce1) suggests that this group of proteins represents a novel IMP (intramembrane protease) family, the glutamate IMPs. There is a conserved sequence motif EExxxR.


Pssm-ID: 460578 [Multi-domain]  Cd Length: 92  Bit Score: 47.55  E-value: 1.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499176622  713 ILALFFLPALGEELVFRVMLLPYPTELnlFWPTLGAMllslvlfllyhpLNALLF----YPrgrnvfFQPIFLGLTGLLA 788
Cdd:pfam02517   7 LLLLALLAPIGEELLFRGYLLPRLRRR--LWPVLAIL------------ISSLLFglahLP------NGPQLFLLAFLLG 66

                          90       100
                  ....*....|....*....|...
gi 499176622  789 VATTAIYWHSGSLWLIAIFHWLV 811
Cdd:pfam02517  67 LILGYLYLRTGSLWAAILLHALN 89
YdiL COG1266
Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, ...
 713-819 5.21e-05

Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440877 [Multi-domain]  Cd Length: 97  Bit Score: 42.86  E-value: 5.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499176622 713 ILALFFLPALGEELVFRVMLLPYpteLNLFWPTLGAMLlslvlfllyhpLNALLFyprGRNVFFQPIFLGLTGLLAVATT 792
Cdd:COG1266    8 LLVVVILAPIAEELLFRGYLLGR---LRRRFGPWLAIL-----------LSSLLF---GLLHLPNLLGFLPAFLLGLVLG 70

                         90       100
                 ....*....|....*....|....*..
gi 499176622 793 AIYWHSGSLWLIAIFHWLVVVTWLMLL 819
Cdd:COG1266   71 LLYLRTGSLWVPILLHALNNLLALLLL 97
Laminin_I pfam06008
Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from ...
 452-574 1.99e-04

Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.


Pssm-ID: 310534 [Multi-domain]  Cd Length: 258  Bit Score: 43.94  E-value: 1.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499176622  452 VKLDVLEDYNfgGSVLSPLDELQKQLQIMMARYRTgdgtgyagVSPAASCVQDSNQALYLAIVGLQQKVQNSPEIITWLA 531
Cdd:pfam06008  40 IQIEILEKEL--SSLAQETEELQKKATQTLAKAQQ--------VNAESERTLGHAKELAEAIKNLIDNIKEINEKVATLG 109

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 499176622  532 QHGNSPENQRFQRLQQLGDRLLTMLKPRGITREDwQNNAATLA 574
Cdd:pfam06008 110 ENDFALPSSDLSRMLAEAQRMLGEIRSRDFGTQL-QNAEAELK 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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