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Conserved domains on  [gi|497587727|ref|WP_009901911|]
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GyrI-like domain-containing protein [Clostridioides difficile]

Protein Classification

AraC family transcriptional regulator; AraC family transcriptional regulator; GyrI-like domain-containing protein; GyrI-like domain-containing protein; AraC family transcriptional regulator; GyrI-like domain-containing protein; GyrI-like domain-containing protein( domain architecture ID 10009001)

AraC family transcriptional regulator regulates diverse functions, including sugar catabolism and responses to stress and virulence; AraC family transcriptional regulator regulates diverse functions, including sugar catabolism and responses to stress and virulence; GyrI-like domain-containing protein adopts a beta-barrel fold similar to the effector-binding region of AraC/XylS transcription activators and may bind a small molecule; GyrI-like domain-containing protein adopts a beta-barrel fold similar to the effector-binding region of AraC/XylS transcription activators and may bind a small molecule; AraC family transcriptional regulator regulates diverse functions, including sugar catabolism and responses to stress and virulence; GyrI-like domain-containing protein adopts a beta-barrel fold similar to the effector-binding region of AraC/XylS transcription activators and may bind a small molecule; GyrI-like domain-containing protein adopts a beta-barrel fold similar to the effector-binding region of AraC/XylS transcription activators and may bind a small molecule

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BltR2 COG4978
GyrI-like small molecule binding domain [Signal transduction mechanisms];
7-147 5.76e-32

GyrI-like small molecule binding domain [Signal transduction mechanisms];


:

Pssm-ID: 444003  Cd Length: 144  Bit Score: 111.25  E-value: 5.76e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497587727   7 ITIAEQSEYCILAIRKTIDfMVEFSEFSKQSFEKISRYLEERGILSSGAPIVCFHNMDLAKLDVEVGFPVATYIDGKNEI 86
Cdd:COG4978    1 VEVKELPAQPVASIRATVP-MDELGELIGEAFGELFAYLAENGIEPAGPPFAIYHDTDEDDVDVEVGVPVAGPLPGTGDI 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 497587727  87 LQRIVPAQKIITAIDLGPYELQDPTLEDLFSWANSNGYKLHGDIYYQYLNDINRPA--SEYLT 147
Cdd:COG4978   80 KVGTLPAGKAATATHRGPYDTLDEAYEALLAWIEENGLEVAGPPREVYLTDPGNEPdpEEWVT 142
 
Name Accession Description Interval E-value
BltR2 COG4978
GyrI-like small molecule binding domain [Signal transduction mechanisms];
7-147 5.76e-32

GyrI-like small molecule binding domain [Signal transduction mechanisms];


Pssm-ID: 444003  Cd Length: 144  Bit Score: 111.25  E-value: 5.76e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497587727   7 ITIAEQSEYCILAIRKTIDfMVEFSEFSKQSFEKISRYLEERGILSSGAPIVCFHNMDLAKLDVEVGFPVATYIDGKNEI 86
Cdd:COG4978    1 VEVKELPAQPVASIRATVP-MDELGELIGEAFGELFAYLAENGIEPAGPPFAIYHDTDEDDVDVEVGVPVAGPLPGTGDI 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 497587727  87 LQRIVPAQKIITAIDLGPYELQDPTLEDLFSWANSNGYKLHGDIYYQYLNDINRPA--SEYLT 147
Cdd:COG4978   80 KVGTLPAGKAATATHRGPYDTLDEAYEALLAWIEENGLEVAGPPREVYLTDPGNEPdpEEWVT 142
AraC_E_bind smart00871
Bacterial transcription activator, effector binding domain; This domain is found in the ...
 6-153 1.85e-10

Bacterial transcription activator, effector binding domain; This domain is found in the probable effector binding domain of a number of different bacterial transcription activators.and is also present in some DNA gyrase inhibitors. The absence of a HTH motif in the DNA gyrase inhibitors is thought to indicate the fact that these do not bind DNA.


Pssm-ID: 214874 [Multi-domain]  Cd Length: 158  Bit Score: 55.95  E-value: 1.85e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497587727     6 NITIAEQSEYCILAIRKTIDFMVEFSEFSKQSFEKISRYLEERGILSSGAPIVCFHN----MDLAKLDVEVGFPVATYID 81
Cdd:smart00871   1 EVRIVELPAFKVAGLRHRGPNEDEKIPELWQRLIQWAKELGLLPVGNSGEPYGVYYDdpddTPDGEFRYDAGVEVSDEVE 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 497587727    82 GKNEILQRIVPAQK--IITAIDLGPYELQDpTLEDLFSWANSNGYKLH---GDIYYQYLNDINRPAS-EYLTKMMLPI 153
Cdd:smart00871  81 APEGVETKTIPAGKyaVFTHKGGSYDEIQE-AWEAIYGEWLPNSGYELrdaGPDFEVYLNDPPDTDPeELVTEIYIPV 157
GyrI-like pfam06445
GyrI-like small molecule binding domain; This family contains the small molecule binding ...
 6-153 5.84e-07

GyrI-like small molecule binding domain; This family contains the small molecule binding domain of a number of different bacterial transcription activators. This family also contains DNA gyrase inhibitors. The GyrI superfamily contains a diad of the SHS2 module, adapted for small-molecule binding. The GyrI superfamily includes a family of secreted forms that is found only in animals and the bacterial pathogen Leptospira.


Pssm-ID: 428947  Cd Length: 153  Bit Score: 46.25  E-value: 5.84e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497587727    6 NITIAEQSEYCILAIRKTIDFmvEFSEFsKQSFEKISRYLEERGILSSGAPI--VCFHN---MDLAKLDVEVGFPVATYI 80
Cdd:pfam06445   1 EVEIVELPAFRVAGLRHRGPY--NEEGI-GALWEELCAWASENGLSPAPSPLigVSYDDpevTEDEELRYDAGVAVPIPV 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 497587727   81 DGKNEILQRIVPAQKIITAIDLGPYELQDPTLEDLFS-WANSNGYKLH-GDIYYQYLNDINRPAS-EYLTKMMLPI 153
Cdd:pfam06445  78 EGPEGVEELELPGGEYAVFRHKGPYDDLQETYAKIYGeWLPESGYERRdGPSFEIYLNDPREVPEeELKTEIYIPV 153
 
Name Accession Description Interval E-value
BltR2 COG4978
GyrI-like small molecule binding domain [Signal transduction mechanisms];
7-147 5.76e-32

GyrI-like small molecule binding domain [Signal transduction mechanisms];


Pssm-ID: 444003  Cd Length: 144  Bit Score: 111.25  E-value: 5.76e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497587727   7 ITIAEQSEYCILAIRKTIDfMVEFSEFSKQSFEKISRYLEERGILSSGAPIVCFHNMDLAKLDVEVGFPVATYIDGKNEI 86
Cdd:COG4978    1 VEVKELPAQPVASIRATVP-MDELGELIGEAFGELFAYLAENGIEPAGPPFAIYHDTDEDDVDVEVGVPVAGPLPGTGDI 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 497587727  87 LQRIVPAQKIITAIDLGPYELQDPTLEDLFSWANSNGYKLHGDIYYQYLNDINRPA--SEYLT 147
Cdd:COG4978   80 KVGTLPAGKAATATHRGPYDTLDEAYEALLAWIEENGLEVAGPPREVYLTDPGNEPdpEEWVT 142
AraC_E_bind smart00871
Bacterial transcription activator, effector binding domain; This domain is found in the ...
 6-153 1.85e-10

Bacterial transcription activator, effector binding domain; This domain is found in the probable effector binding domain of a number of different bacterial transcription activators.and is also present in some DNA gyrase inhibitors. The absence of a HTH motif in the DNA gyrase inhibitors is thought to indicate the fact that these do not bind DNA.


Pssm-ID: 214874 [Multi-domain]  Cd Length: 158  Bit Score: 55.95  E-value: 1.85e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497587727     6 NITIAEQSEYCILAIRKTIDFMVEFSEFSKQSFEKISRYLEERGILSSGAPIVCFHN----MDLAKLDVEVGFPVATYID 81
Cdd:smart00871   1 EVRIVELPAFKVAGLRHRGPNEDEKIPELWQRLIQWAKELGLLPVGNSGEPYGVYYDdpddTPDGEFRYDAGVEVSDEVE 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 497587727    82 GKNEILQRIVPAQK--IITAIDLGPYELQDpTLEDLFSWANSNGYKLH---GDIYYQYLNDINRPAS-EYLTKMMLPI 153
Cdd:smart00871  81 APEGVETKTIPAGKyaVFTHKGGSYDEIQE-AWEAIYGEWLPNSGYELrdaGPDFEVYLNDPPDTDPeELVTEIYIPV 157
GyrI-like pfam06445
GyrI-like small molecule binding domain; This family contains the small molecule binding ...
 6-153 5.84e-07

GyrI-like small molecule binding domain; This family contains the small molecule binding domain of a number of different bacterial transcription activators. This family also contains DNA gyrase inhibitors. The GyrI superfamily contains a diad of the SHS2 module, adapted for small-molecule binding. The GyrI superfamily includes a family of secreted forms that is found only in animals and the bacterial pathogen Leptospira.


Pssm-ID: 428947  Cd Length: 153  Bit Score: 46.25  E-value: 5.84e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497587727    6 NITIAEQSEYCILAIRKTIDFmvEFSEFsKQSFEKISRYLEERGILSSGAPI--VCFHN---MDLAKLDVEVGFPVATYI 80
Cdd:pfam06445   1 EVEIVELPAFRVAGLRHRGPY--NEEGI-GALWEELCAWASENGLSPAPSPLigVSYDDpevTEDEELRYDAGVAVPIPV 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 497587727   81 DGKNEILQRIVPAQKIITAIDLGPYELQDPTLEDLFS-WANSNGYKLH-GDIYYQYLNDINRPAS-EYLTKMMLPI 153
Cdd:pfam06445  78 EGPEGVEELELPGGEYAVFRHKGPYDDLQETYAKIYGeWLPESGYERRdGPSFEIYLNDPREVPEeELKTEIYIPV 153
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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