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Conserved domains on  [gi|497581776|ref|WP_009895960|]
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MFS transporter [Burkholderia thailandensis]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 11-410 8.94e-55

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17503:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 380  Bit Score: 187.01  E-value: 8.94e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  11 YLLGFSIDLANMFAINAAYPALQRELHASVTQLAWIGNIYMLGLTVVIPLGAWLAHRFGERRLLAASLLVFALGSAGAAS 90
Cdd:cd17503    1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  91 AQSIGALLASRLVQGLGGGLLIPVGQAMTYRAYPRETRARLTSIVMMVALLVPATSPALGGVIVDHASWRAVFagmlala 170
Cdd:cd17503   81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIF------- 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 171 alacvlalawlpadvsndaprpldaaglglsaagLIALLLGftfasrrgapmpaIAALAIacvaglayvrharrssAPLL 250
Cdd:cd17503  154 ----------------------------------YINLPIG-------------ILALLL----------------APLL 170

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 251 DLALLSQPLLRVGVVIYLCVPGVFTGVNLIASLFLQNALGLSATQVGALMVPWSAASFAAIATTRRAFPLHGPRPLLACG 330
Cdd:cd17503  171 DLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAG 250

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 331 IVIACIGVALLAtPLAAHEAGRMLA--YAAMGFGASLCTSTSQSAAFLDVPADRMGEASALWNINRQLSFCLGSAVLGSA 408
Cdd:cd17503  251 LLLLALGTLLLA-FLTPDTSLWLIIlpLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATL 329


                 ..
gi 497581776 409 LN 410
Cdd:cd17503  330 LT 331
 
Name Accession Description Interval E-value
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 11-410 8.94e-55

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 187.01  E-value: 8.94e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  11 YLLGFSIDLANMFAINAAYPALQRELHASVTQLAWIGNIYMLGLTVVIPLGAWLAHRFGERRLLAASLLVFALGSAGAAS 90
Cdd:cd17503    1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  91 AQSIGALLASRLVQGLGGGLLIPVGQAMTYRAYPRETRARLTSIVMMVALLVPATSPALGGVIVDHASWRAVFagmlala 170
Cdd:cd17503   81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIF------- 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 171 alacvlalawlpadvsndaprpldaaglglsaagLIALLLGftfasrrgapmpaIAALAIacvaglayvrharrssAPLL 250
Cdd:cd17503  154 ----------------------------------YINLPIG-------------ILALLL----------------APLL 170

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 251 DLALLSQPLLRVGVVIYLCVPGVFTGVNLIASLFLQNALGLSATQVGALMVPWSAASFAAIATTRRAFPLHGPRPLLACG 330
Cdd:cd17503  171 DLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAG 250

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 331 IVIACIGVALLAtPLAAHEAGRMLA--YAAMGFGASLCTSTSQSAAFLDVPADRMGEASALWNINRQLSFCLGSAVLGSA 408
Cdd:cd17503  251 LLLLALGTLLLA-FLTPDTSLWLIIlpLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATL 329


                 ..
gi 497581776 409 LN 410
Cdd:cd17503  330 LT 331
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 25-404 1.81e-40

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 151.38  E-value: 1.81e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776   25 INAAYPALQRELHASVTQLAWIGNIYMLGLTVVIPLGAWLAHRFGERRLLAASLLVFALGSAGAASAQSIGALLASRLVQ 104
Cdd:TIGR00711  21 VNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQ 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  105 GLGGGLLIPVGQAMTYRAYPRETRARLTSIVMMVALLVPATSPALGGVIVDHASWRAVFAGMLALAALACVLALAWLPAD 184
Cdd:TIGR00711 101 GFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVVVAFFILPRD 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  185 VSNdAPRPLDAAGLGLSAAGLIALLLGFTFASRRG--APMPAIAALAIACVAGLAYVRHARRSSAPLLDLALLSQPLLRV 262
Cdd:TIGR00711 181 KPA-ASENFDFLGLLLLSVGLGSLLYGLSEGPERGwfDSNEILILSITGLVAIIAFVVWELTDDNPLVDLRLFKYRNFTI 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  263 GVVIYLCVPGVFTGVNLIASLFLQNALGLSATQVGALMVPWSAASFAAIATTRRAFPLHGPRPLLACGIVIACIGVALLA 342
Cdd:TIGR00711 260 GCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLVTIGLILYAVGFYWRA 339

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 497581776  343 TPLA--AHEAGRMLAYAAMGFGASLCTSTSQSAAFLDVPADRMGEASALWNINRQLSFCLGSAV 404
Cdd:TIGR00711 340 FTFTpdTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGTAL 403
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
2-391 3.84e-26

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 108.52  E-value: 3.84e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776   2 SARSRIAAVYLLGFSIDLANMFAINAAYPALQRELHASVTQLAWIGNIYMLGLTVVIPLGAWLAHRFGERRLLAASLLVF 81
Cdd:COG2814    6 RRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  82 ALGSAGAASAQSIGALLASRLVQGLGGGLLIPVGQAMTYRAYPRETRARLTSIVMMVALLVPATSPALGGVIVDHASWRA 161
Cdd:COG2814   86 ALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRW 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 162 VFAGmlalaalacvlalawlpadvsndaprpldAAGLGLSAAGLIALLLGFTFASRRGAPMPAIAalaiacvaglayvrh 241
Cdd:COG2814  166 VFLV-----------------------------NAVLALLALLLLLRLLPESRPAARARLRGSLR--------------- 201

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 242 arrssaplldlALLSQPLLRVGVVIYLCVPGVFTGVNLIASLFLQNALGLSATQVGALMVPWSAASFAAIATTRRAFPLH 321
Cdd:COG2814  202 -----------ELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF 270

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 322 GPRPLLACGIVIACIGVALLAtpLAAHEAGRMLAYAAMGFGASLCTSTSQSAAFLDVPADRMGEASALWN 391
Cdd:COG2814  271 GRRRLLLIGLLLLALGLLLLA--LAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYN 338
MFS_1 pfam07690
Major Facilitator Superfamily;
10-402 5.75e-19

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 87.86  E-value: 5.75e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776   10 VYLLGFSIDLANMFAINAAYPALQRELHASVTQLAWIGNIYMLGLTVVIPLGAWLAHRFGERRLLAASLLVFALGSAGAA 89
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776   90 SAQSIGALLASRLVQGLGGGLLIPVGQAMTYRAYPRETRARLTSIVMMVALLVPATSPALGGVIVDHASWRAVFagmlal 169
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAF------ 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  170 aalacvlalawlpadvsndaprpldaaglgLSAAGLIALLLGFTFASRRGAPMPAIAALAIACVAGLAYVRHARRSSAPL 249
Cdd:pfam07690 155 ------------------------------LILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLW 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  250 LDLALLSQPLLRVGVVIYLcvpgvftgvnliasLFLQNALGLSATQVGALMVPWSAAS-FAAIATTRRAFPLHGPRPLLA 328
Cdd:pfam07690 205 LLLALLLFGFAFFGLLTYL--------------PLYQEVLGLSALLAGLLLGLGGLLGaIGRLLLGRLSDRLGRRRRLLL 270

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 497581776  329 CGIVIACIGVALLATPLAAHEAGRMLAYAAMGFGASLCTSTSQSAAFLDVPADRMGEASALWNINRQLSFCLGS 402
Cdd:pfam07690 271 ALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
PRK10504 PRK10504
putative transporter; Provisional
 25-302 5.39e-17

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 83.24  E-value: 5.39e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  25 INAAYPALQRELHASVTQLAWIGNIYMLGLTVVIPLGAWLAHRFGERRLLAASLLVFALGSAGAASAQSIGALLASRLVQ 104
Cdd:PRK10504  29 VNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLARVLQ 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 105 GLGGGLLIPVGQAMTYRAYPRETRARLTSIVMMVALLVPATSPALGGVIVDHASWRAVF-----AGMLALAALACVLALA 179
Cdd:PRK10504 109 GVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFlinipVGIIGAIATLMLMPNY 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 180 WLPadvsndaPRPLDAAGLGLSAAGLIALLLGFTFASRRGAPMPAIAAL-AIACVAGLAYVRHARRSSAPLLDLALLSQP 258
Cdd:PRK10504 189 TMQ-------TRRFDLSGFLLLAVGMATLTLALDGSKGLGLSPLAIAGLvAVGVVALLLYLLHARNNNRALFSLKLFRTR 261

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 497581776 259 LLRVGVViylcvpGVFTG------VNLIASLFLQNALGLSATQVGALMVP 302
Cdd:PRK10504 262 TFSLGLA------GSFAGrigsgmLPFMTPVFLQIGLGFSPFHAGLMMIP 305
 
Name Accession Description Interval E-value
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 11-410 8.94e-55

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 187.01  E-value: 8.94e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  11 YLLGFSIDLANMFAINAAYPALQRELHASVTQLAWIGNIYMLGLTVVIPLGAWLAHRFGERRLLAASLLVFALGSAGAAS 90
Cdd:cd17503    1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  91 AQSIGALLASRLVQGLGGGLLIPVGQAMTYRAYPRETRARLTSIVMMVALLVPATSPALGGVIVDHASWRAVFagmlala 170
Cdd:cd17503   81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIF------- 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 171 alacvlalawlpadvsndaprpldaaglglsaagLIALLLGftfasrrgapmpaIAALAIacvaglayvrharrssAPLL 250
Cdd:cd17503  154 ----------------------------------YINLPIG-------------ILALLL----------------APLL 170

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 251 DLALLSQPLLRVGVVIYLCVPGVFTGVNLIASLFLQNALGLSATQVGALMVPWSAASFAAIATTRRAFPLHGPRPLLACG 330
Cdd:cd17503  171 DLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAG 250

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 331 IVIACIGVALLAtPLAAHEAGRMLA--YAAMGFGASLCTSTSQSAAFLDVPADRMGEASALWNINRQLSFCLGSAVLGSA 408
Cdd:cd17503  251 LLLLALGTLLLA-FLTPDTSLWLIIlpLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATL 329


                 ..
gi 497581776 409 LN 410
Cdd:cd17503  330 LT 331
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 25-404 1.81e-40

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 151.38  E-value: 1.81e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776   25 INAAYPALQRELHASVTQLAWIGNIYMLGLTVVIPLGAWLAHRFGERRLLAASLLVFALGSAGAASAQSIGALLASRLVQ 104
Cdd:TIGR00711  21 VNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQ 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  105 GLGGGLLIPVGQAMTYRAYPRETRARLTSIVMMVALLVPATSPALGGVIVDHASWRAVFAGMLALAALACVLALAWLPAD 184
Cdd:TIGR00711 101 GFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVVVAFFILPRD 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  185 VSNdAPRPLDAAGLGLSAAGLIALLLGFTFASRRG--APMPAIAALAIACVAGLAYVRHARRSSAPLLDLALLSQPLLRV 262
Cdd:TIGR00711 181 KPA-ASENFDFLGLLLLSVGLGSLLYGLSEGPERGwfDSNEILILSITGLVAIIAFVVWELTDDNPLVDLRLFKYRNFTI 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  263 GVVIYLCVPGVFTGVNLIASLFLQNALGLSATQVGALMVPWSAASFAAIATTRRAFPLHGPRPLLACGIVIACIGVALLA 342
Cdd:TIGR00711 260 GCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLVTIGLILYAVGFYWRA 339

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 497581776  343 TPLA--AHEAGRMLAYAAMGFGASLCTSTSQSAAFLDVPADRMGEASALWNINRQLSFCLGSAV 404
Cdd:TIGR00711 340 FTFTpdTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGTAL 403
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 12-414 2.26e-29

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 118.04  E-value: 2.26e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  12 LLGFSIDLANMFAINAAYPALQRELHASVTQLAWIGNIYMLGLTVVIPLGAWLAHRFGERRLLAASLLVFALGSAGAASA 91
Cdd:cd17321    2 LLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  92 QSIGALLASRLVQGLGGGLLIPVGQAMTYRAYPRETRARLTSIVMMVALLVPATSPALGGVIVDHASWRAVFAGMLalaa 171
Cdd:cd17321   82 PSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINV---- 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 172 lacvlalawlpadvsndaprpldaaglglsAAGLIALLLGftfasrrgapmpaiaalaiacvaglayvrharrssaplld 251
Cdd:cd17321  158 ------------------------------PIGLVALLLA---------------------------------------- 167

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 252 lallsqPLLRVGVVIYLCVPGVFTGVNLIASLFLQNALGLSATQVGALMVPWSAASFAAIATTRRAFPLHGPRPLLACGI 331
Cdd:cd17321  168 ------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGL 241

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 332 VIACIGVALLATPLAAHEAGRML-AYAAMGFGASLCTSTSQSAAFLDVPADRMGEASALWNINRQLSFCLGSAVLGSALN 410
Cdd:cd17321  242 LLTAVGLLLLALLGADSSVWLLLpGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLT 321


                 ....
gi 497581776 411 FLLA 414
Cdd:cd17321  322 AGLS 325
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
2-391 3.84e-26

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 108.52  E-value: 3.84e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776   2 SARSRIAAVYLLGFSIDLANMFAINAAYPALQRELHASVTQLAWIGNIYMLGLTVVIPLGAWLAHRFGERRLLAASLLVF 81
Cdd:COG2814    6 RRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  82 ALGSAGAASAQSIGALLASRLVQGLGGGLLIPVGQAMTYRAYPRETRARLTSIVMMVALLVPATSPALGGVIVDHASWRA 161
Cdd:COG2814   86 ALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRW 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 162 VFAGmlalaalacvlalawlpadvsndaprpldAAGLGLSAAGLIALLLGFTFASRRGAPMPAIAalaiacvaglayvrh 241
Cdd:COG2814  166 VFLV-----------------------------NAVLALLALLLLLRLLPESRPAARARLRGSLR--------------- 201

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 242 arrssaplldlALLSQPLLRVGVVIYLCVPGVFTGVNLIASLFLQNALGLSATQVGALMVPWSAASFAAIATTRRAFPLH 321
Cdd:COG2814  202 -----------ELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF 270

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 322 GPRPLLACGIVIACIGVALLAtpLAAHEAGRMLAYAAMGFGASLCTSTSQSAAFLDVPADRMGEASALWN 391
Cdd:COG2814  271 GRRRLLLIGLLLLALGLLLLA--LAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYN 338
MFS_1 pfam07690
Major Facilitator Superfamily;
10-402 5.75e-19

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 87.86  E-value: 5.75e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776   10 VYLLGFSIDLANMFAINAAYPALQRELHASVTQLAWIGNIYMLGLTVVIPLGAWLAHRFGERRLLAASLLVFALGSAGAA 89
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776   90 SAQSIGALLASRLVQGLGGGLLIPVGQAMTYRAYPRETRARLTSIVMMVALLVPATSPALGGVIVDHASWRAVFagmlal 169
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAF------ 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  170 aalacvlalawlpadvsndaprpldaaglgLSAAGLIALLLGFTFASRRGAPMPAIAALAIACVAGLAYVRHARRSSAPL 249
Cdd:pfam07690 155 ------------------------------LILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLW 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  250 LDLALLSQPLLRVGVVIYLcvpgvftgvnliasLFLQNALGLSATQVGALMVPWSAAS-FAAIATTRRAFPLHGPRPLLA 328
Cdd:pfam07690 205 LLLALLLFGFAFFGLLTYL--------------PLYQEVLGLSALLAGLLLGLGGLLGaIGRLLLGRLSDRLGRRRRLLL 270

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 497581776  329 CGIVIACIGVALLATPLAAHEAGRMLAYAAMGFGASLCTSTSQSAAFLDVPADRMGEASALWNINRQLSFCLGS 402
Cdd:pfam07690 271 ALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 1-285 2.45e-17

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 82.17  E-value: 2.45e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776   1 MSARSRIAAVYLLGFSIDLANMFAINAAYPALQRELHASVTQLAWIGNIYMLGLTVVIPLGAWLAHRFGERRLLAASLLV 80
Cdd:COG0477    9 TRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  81 FALGSAGAASAQSIGALLASRLVQGLGGGLLIPVGQAMTYRAYPRETRARLTSIVMMVALLVPATSPALGGVIVDHASWR 160
Cdd:COG0477   89 FGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWR 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 161 AVFAGMLALAALACVLALAWLPADVSNDAPRPLDAAGLGLSAAGLIALLLGFTFASRRGAPMPAIAALAIACVAGLAYVR 240
Cdd:COG0477  169 WIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLL 248

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 497581776 241 HARRSSAPLLDLALLSQPLLRVGVVIYLCVPGVFTGVNLIASLFL 285
Cdd:COG0477  249 ALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLAL 293
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 28-410 2.86e-17

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 83.01  E-value: 2.86e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  28 AYPALQRELHASVTQLAWIGNIYMLGLTVVIPLGAWLAHRFGERRLLAASLLVFALGSAGAASAQSIGALLASRLVQGLG 107
Cdd:cd17320   21 ALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLG 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 108 GGLLIPVGQAMTYRAYPRETRARLTSIVMMVALLVPATSPALGGVIVDHASWRAVFAGMlalaalacvlalawlpadvsn 187
Cdd:cd17320  101 AAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFL--------------------- 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 188 daprpldaAGLGLSAAGLIALLLGFTFASRRGAPMPAIAALAIAcvaglayvrharrssaplldlALLSQPLLRVGVVIY 267
Cdd:cd17320  160 --------ALLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAYK---------------------RVLKNRRFLGYALAL 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 268 LCVPGVFTGVNLIASLFLQNALGLSATQVGALMVPWSAASFAAIATTRRAFPLHGPRPLLACGIVIACIGVALL---ATP 344
Cdd:cd17320  211 GLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLllaALL 290

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 497581776 345 LAAHEAGRMLAYAAMGFGASLCTSTSQSAAfLDVPADRMGEASALWNINRQLSFCLGSAVLGSALN 410
Cdd:cd17320  291 GGLSLWPLVAPLFLIFFGFGLIFPNATSLA-LEPFPHVAGTASALLGFLQFLIGALAGALVGLLPN 355
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 12-406 3.89e-17

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 82.62  E-value: 3.89e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  12 LLGFSIDLANMFAINAAYPALQRELHASVTQLAWIGNIYMLGLTVVIPLGAWLAHRFGERRLLAASLLVFALGSAGAASA 91
Cdd:cd17325    2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  92 QSIGALLASRLVQGLGGGLLIPVGQAMTYRAYPRETRARLTSIVMMVALLVPATSPALGGVIVDHASWRAVFagmlalaa 171
Cdd:cd17325   82 TSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPF-------- 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 172 lacvlalawlpadvsndaprpldaagLGLSAAGLIALLLGFTFASRRGAPMPAiaalaiacvaglayvRHARRSSAPLLD 251
Cdd:cd17325  154 --------------------------LVCAALALLALVLALLLLPEPRPPPNK---------------RAVSAARLRSGL 192

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 252 LALLSQPLLRVGVVIYLCVPGVFTGVNLIASLFLQNALGLSATQVGALMVPWSAASFAAIATTRRAFPLHGPRPLLACGI 331
Cdd:cd17325  193 RLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGL 272

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 497581776 332 VIacIGVALLATPLAAHEAGRMLAYAAMGFGASLCTSTSQSAAFLDVPADRMGEASALWNINRQLSFCLGSAVLG 406
Cdd:cd17325  273 LL--SAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGG 345
PRK10504 PRK10504
putative transporter; Provisional
 25-302 5.39e-17

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 83.24  E-value: 5.39e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  25 INAAYPALQRELHASVTQLAWIGNIYMLGLTVVIPLGAWLAHRFGERRLLAASLLVFALGSAGAASAQSIGALLASRLVQ 104
Cdd:PRK10504  29 VNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLARVLQ 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 105 GLGGGLLIPVGQAMTYRAYPRETRARLTSIVMMVALLVPATSPALGGVIVDHASWRAVF-----AGMLALAALACVLALA 179
Cdd:PRK10504 109 GVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFlinipVGIIGAIATLMLMPNY 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 180 WLPadvsndaPRPLDAAGLGLSAAGLIALLLGFTFASRRGAPMPAIAAL-AIACVAGLAYVRHARRSSAPLLDLALLSQP 258
Cdd:PRK10504 189 TMQ-------TRRFDLSGFLLLAVGMATLTLALDGSKGLGLSPLAIAGLvAVGVVALLLYLLHARNNNRALFSLKLFRTR 261

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 497581776 259 LLRVGVViylcvpGVFTG------VNLIASLFLQNALGLSATQVGALMVP 302
Cdd:PRK10504 262 TFSLGLA------GSFAGrigsgmLPFMTPVFLQIGLGFSPFHAGLMMIP 305
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 27-409 1.62e-15

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 77.62  E-value: 1.62e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  27 AAYPALQRELHASVTQLAWIGNIYMLGLTVVIPLGAWLAHRFGERRLLAASLLVFALGSAGAASAQSIGALLASRLVQgL 106
Cdd:cd17504   17 PALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQ-G 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 107 GGGLLIPVGQAMTYRAYPRETRARLTSIVMMVALLVPATSPALGGVIVDHASWRAVFAGMLalaalacvlalawlpadvs 186
Cdd:cd17504   96 IGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAA------------------- 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 187 ndaprpldaaglglsaaglialllgftfasrrgapmpAIAALAIACVaglayvrharrssaPLLDLALLSQPLLRVGVVI 266
Cdd:cd17504  157 -------------------------------------PVAVLLAALV--------------PLIDLRLLRRRNVLLANIT 185

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 267 YLCVPGVFTGVNLIASLFLQNA----LGLSATQVGALMVPWSAASFAAIATTRRAFPLHGPRPLLACGIVIACIGVALLA 342
Cdd:cd17504  186 ALLAGFGMFMVFQLLPQLLQLPtptgFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLA 265

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 497581776 343 TpLAAHEAGRMLAYAAMGFGASLCTSTSQSAAFLDVPADRMGEASALWNINRQLSFCLGSAVLGSAL 409
Cdd:cd17504  266 L-LHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAIL 331
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
4-166 4.17e-14

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 73.37  E-value: 4.17e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776   4 RSRIAAVYLLGFSIDLANMFAINAAYPALQRELHASVTQLAWIGNIYMLGLTVVIPLGAWLAHRFGERRLLAASLLVFAL 83
Cdd:COG2271    8 RWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  84 GSAGAASAQSIGALLASRLVQGLGGGLLIPVGQAMTYRAYPRETRARLTSIVMMVALLVPATSPALGGVIVDHASWRAVF 163
Cdd:COG2271   88 ATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAF 167


                 ...
gi 497581776 164 AGM 166
Cdd:COG2271  168 LIL 170
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 25-404 8.38e-14

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 72.21  E-value: 8.38e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  25 INAAYPALQRELHaSVTQLAWIGNIYMLGLTVVIPLGAWLAHRFGERRLLAASLLVFALGSAGAASAQSIGALLASRLVQ 104
Cdd:cd17502   15 VATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQ 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 105 GLGGGLLIPVGQAMTYRAYPRETRARL---TSIVMMVALLVpatSPALGGVIVDHASWRAVFagmlalaalacvlalawl 181
Cdd:cd17502   94 GIGGGGLMSLAFIIIADLVPPRERGKYqgyIGAVFGIASVA---GPLIGGAFTDHLSWRWCF------------------ 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 182 padvsndaprpldaaGLGLSAAGLIALLLgftfasrrgaPMPAIAALAIACVAGLAYvrharrssaplldlallsqpllr 261
Cdd:cd17502  153 ---------------YINLPIGGLALALL----------RTILLSSIFGFLFGGALF----------------------- 184

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 262 vGVVIYLcvpgvftgvnliaSLFLQNALGLSATQVG----ALMVPWSAASFAAIATTRRafpLHGPRPLLACGIVIACIG 337
Cdd:cd17502  185 -GLIYYL-------------PLYFQLVLGDSATKSGvrllPLIIGLVIGSIISGALISK---TGRYKPLIVIGTILMSVG 247

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 497581776 338 VALLAT-PLAAHEAGRMLAYAAMGFGASLCTSTSQSAAFLDVPADRMGEASALWNINRQLSFCLGSAV 404
Cdd:cd17502  248 AGLLTTlTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAI 315
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 20-409 1.19e-12

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 69.12  E-value: 1.19e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  20 ANMFAINAAYPALQRELHASVTQLAWIGNIYMLGLTVVIPLGAWLAHRFGERRLLAASLLVFALGSAGAASAQSIGALLA 99
Cdd:cd17324   13 TTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 100 SRLVQGLGGGLLIPVGQAMTYRAYPRETRARLTSIVMMVALLVPATSPALGGVIVDHASWRAVFAGMlalaalacvlala 179
Cdd:cd17324   93 ARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAI------------- 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 180 wlpadvsndaprpldaAGLGLSAAGLIALLLgftfasrrgapmPAIAAlaiacvaglayvRHARRSSAPLLDLALLSQPL 259
Cdd:cd17324  160 ----------------AVLALLAALLLWRLL------------PSLPP------------KKPGSLGLLSSLLLLLRNPR 199

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 260 LRVGVVIYLCVPGVFTGVNLIASLFLQNALGLSATQVGALMVPWSAASFAAIATTRRAFPLHGPRPLLACGIVIACIGVA 339
Cdd:cd17324  200 LRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLL 279

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 340 LlaTPLAAHEAGRMLAYAAMGFGASLCTSTSQSAAFLDVPADRmGEASALWNINRQLSFCLGSAVLGSAL 409
Cdd:cd17324  280 L--TLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEAR-GLASSLYLAAYNLGGALGAALGGLVL 346
PRK14995 PRK14995
SmvA family efflux MFS transporter;
28-411 3.03e-12

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 68.60  E-value: 3.03e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  28 AYPALQRELHASVTQLAWIGNIYMLGLT-VVIPLGAwLAHRFGERRLLAASLLVFALGSAGAASAQSIGALLASRLVQGL 106
Cdd:PRK14995  28 AAPTLSMTLGASGNELLWIIDIYSLVMAgMVLPMGA-LGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIATRALLAI 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 107 GGGLLIPVGQAMTYRAYPRET-RARLTSIVMMVALLVPATSPALGGVIVDHASWRAVFAGMLALAALACVLALAWLPadv 185
Cdd:PRK14995 107 GAAMIVPATLAGIRATFTEEKqRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMGLTARYVP--- 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 186 sNDAPRPLDAAGLGlSAAGLIALLLGFTFASRRG-----APMPAIAALAIACVAGLAYVRHARRSSAPLLDLALLSQPLL 260
Cdd:PRK14995 184 -RQAGRRDQPLNLG-HALMLIVAILLLVYSAKTAlkgflSLWVTSLTLLTGALLLGLFIRTQLAASRPMIDMRLFTHRII 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 261 RVGVVIYLCVPGVFTGVNLIASLFLQNALGLSATQVGALMVPWSAAS-----FAAIATTRRafplhGPRPLLACGIVIAc 335
Cdd:PRK14995 262 LSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASgfsgpIAGILVSRL-----GLRLVATGGMALS- 335

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 497581776 336 iGVALLATPLAAHEAGRMLAYAAM---GFGASLCTSTSQSAAFLDVPADRMGEASALWNINRQLSFCLGSAVLGSALNF 411
Cdd:PRK14995 336 -ALSFYGLAMTDFSTQQWQAWGLMallGFSAASALLASTSAIMAAAPPEKAAAAGAIETMAYELGAGLGIAIFGLLLSR 413
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 28-164 1.14e-11

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 66.25  E-value: 1.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776   28 AYPALQRELHASVTQLAWIGNIYMLGLTVVIPLGAWLAHRFGERRLLAASLLVFALGSAGAASAQSIGALLASRLVQGLG 107
Cdd:TIGR00710  27 AFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFG 106

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 497581776  108 GGLLIPVGQAMTYRAYPRETRARLTSIVMMVALLVPATSPALGGVIVDHASWRAVFA 164
Cdd:TIGR00710 107 ASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFA 163
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 4-163 1.01e-10

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 62.97  E-value: 1.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776   4 RSRIAAVYLLGFSIDLANMFAINAAYPALQRELHASVTQLAWIGNIYMLGLTVVIPLGAWLAHRFGERRLLAASLLVFAL 83
Cdd:cd17319    1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  84 GSAGAASAQSIGALLASRLVQGLGGGLLIPVGQAMTYRAYPRETRARLTSIVMMVALLVPATSPALGGVIVDHASWRAVF 163
Cdd:cd17319   81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 11-410 1.93e-10

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 62.44  E-value: 1.93e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  11 YLLGFSIDLANMFAINAAYPALQRELHASVTQLAWIGNIYMLGLTVVIPLGAWLAHRFGERRLLAASLLVFALGSAGAAS 90
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  91 AQSIGALLASRLVQGLGGGLLIPVGQAMTYRAYPRETRARLTSIVMMVALLVPATSPALGGVIVDH--ASWRAVFAGMla 168
Cdd:cd06174   81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIA-- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 169 laalacvlalawlpadvsndaprpldaaglglSAAGLIALLLGFTFasrrgapmpaIAALAIACVAGLAYVRHARRSSAP 248
Cdd:cd06174  159 --------------------------------AALALLAAILLLLV----------VPDPPESARAKNEEASSKSVLKLL 196

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 249 LLdlaLLSQPLLRVGVVIYLCVPGVFTGVNLIASLFLQNALGLSATQVGALMVPWSAASFAAIATTRRAFPLHGPRPLLA 328
Cdd:cd06174  197 KR---VLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLL 273

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 329 cGIVIACIGVALLATPLAAHEAGRMLAYAAMGFGASLCTSTSQSAAFLDVPADRMGEASALWNINRQLSFCLGSAVLGSA 408
Cdd:cd06174  274 -LIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFL 352


                 ..
gi 497581776 409 LN 410
Cdd:cd06174  353 LA 354
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 30-165 4.68e-10

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 61.05  E-value: 4.68e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  30 PALQRELHASVTQLAWIGNIYMLGLTVVIPLGAWLAHRFGERRLLAASLLVFALGSAGAASAQSIGALLASRLVQGLGGG 109
Cdd:cd17474   23 PAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAA 102

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 497581776 110 LLIPVGQAMTYRAYPRETRARLTSIVMMVALLVPATSPALGGVIVDHaSWRAVFAG 165
Cdd:cd17474  103 GLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI-SWRYPFFL 157
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 23-391 5.68e-09

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 57.58  E-value: 5.68e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  23 FAINAAYPALQRELHASVTQLA-WIGNIYMLGLTVVIPLGAWLAHRFGERRLLAASLLVFALGSAGAASAQSIGALLASR 101
Cdd:cd17473   16 AAIAPALPAIAQHFVPNSELLVpLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASR 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 102 LVQGLGGGLLIPVGQAMTYRAYPRETRARLTSIVMMVALLVPATSPALGGVIVDHaSWRAVFAGMlalaalacvlalawl 181
Cdd:cd17473   96 ALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEI-GWRAPFLVY--------------- 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 182 padvsndaprpldaaglglsaagLIALLlgftfasrrgapmpaIAALAIACVAGLAYVRHARRSSAPLLDLALLSQPLLR 261
Cdd:cd17473  160 -----------------------LLALP---------------VLILVLLFLPEPARKSKSAASPGAATAAALPWKRVLP 201

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 262 VGVVIYLCVPGVFTGVNLIaSLFLQNALGLSATQVGALMVPWSAASFAAIATTRRAFPLHGPRPLLACGIVIACIGVALL 341
Cdd:cd17473  202 IYFLAFLAMLLFYVIPIQL-PFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLL 280

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 497581776 342 AtpLAAHEAGRMLAYAAMGFGASLCTSTSQSAAFLDVPADRMGEASALWN 391
Cdd:cd17473  281 A--LASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVT 328
2_A_01_02 TIGR00880
Multidrug resistance protein;
49-163 6.06e-08

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 51.50  E-value: 6.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776   49 IYMLGLTVVIPLGAWLAHRFGERRLLAASLLVFALGSAGAASAQSIGALLASRLVQGLGGGLLIPVGQAMTYRAYPRETR 128
Cdd:TIGR00880   6 GYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEER 85

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 497581776  129 ARLTSIVMMVALLVPATSPALGGVIVDHASWRAVF 163
Cdd:TIGR00880  86 GVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPF 120
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
2-365 4.23e-07

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 51.81  E-value: 4.23e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776   2 SARSRIAAVYLLGFSIDLANMFAINAAYPALQRELHASVTQLAWIGNIYMLGLTVVIPLGAWLAHRFGERRLLAASLLVF 81
Cdd:COG2223    1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  82 ALGSAGAASAQSIGALLASRLVQGLGGGLLIPVGQAMTYRAYPRETRARLTSIVMMVALLVPATSPALGGVIVDHASWRA 161
Cdd:COG2223   81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 162 VFagmlalaalacvlalawlpadvsndaprpldaagLGLSAAGLIALLLGFTFASRRGAPMPAIAALAIACVaglayvrh 241
Cdd:COG2223  161 AF----------------------------------LILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQ-------- 198

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 242 arrssaplldLALLSQPLLRVGVVIYLCVPGVFTGVNLIASLFLQNALGLSATQVGALM-VPWSAASFAAIATTRRAFPL 320
Cdd:COG2223  199 ----------LEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAaLFALLGALGRPLGGWLSDRI 268

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 497581776 321 HGPRPLLACGIV--IACIGVALLATPLAAHEAGRMLAYAAMGFGASL 365
Cdd:COG2223  269 GGRRVLLIVFALmaLGLLLLALALGSLWLFLVLFLLLGLALGGGNGA 315
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
28-164 4.68e-07

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 51.82  E-value: 4.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  28 AYPALQRELHASVTQLAWIGNIYMLGLTVVIPLGAWLAHRFGERRLLAASLLVFALGSAGAASAQSIGALLASRLVQGLG 107
Cdd:PRK11043  28 AFKAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVG 107

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 497581776 108 GGLLIPVGQAMTYRAYPRETRARLTSIVMMVALLVPATSPALGGVIVDHASWRAVFA 164
Cdd:PRK11043 108 VCSAAVIWQALVIDRYPAQKANRVFATIMPLVALSPALAPLLGAWLLNHFGWQAIFA 164
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
2-389 7.84e-07

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 51.01  E-value: 7.84e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776   2 SARSRIAAVYLLGFSIDLANMfAINAAYPALQRELHASVTQLAWIGNIYMLGLTVVIPLGAWLAHRFGERRLLAASLLVF 81
Cdd:COG0738    5 NYRRALIAIYLLFFLWGFATA-LWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLM 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  82 ALGSAGAASAQSIGALLASRLVQGLGGGLLIPVGQAMTYRAYPRETRARLTS--IVMMVALLVpatSPALGGVIVDH--- 156
Cdd:COG0738   84 ALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLlhAFFSLGALL---GPLLGGLLILLgls 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 157 ASWRAVFAGMlalaalacvlalawlpadvsndaprpldaaglglsaaGLIALLLGFTFAsrrGAPMPAIAAlaiacvagl 236
Cdd:COG0738  161 LSWHLPYLIL-------------------------------------AVLLLLLALLFL---RSKLPEIEE--------- 191

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 237 ayvRHARRSSAPLLDLALLSQPLLRVGVVIYLCVPGVFTGVNLIASLFLQNALGLSATQVGALMvpwsAASFAAIATTR- 315
Cdd:COG0738  192 ---EEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGL----SLFWGGMTIGRf 264

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 497581776 316 ---RAFPLHGPRPLLACGIVIACIGVALLAtpLAAHEAGRMLAYAAMGFGASLCTSTSQSAAFLDVPADRMGEASAL 389
Cdd:COG0738  265 lggFLLKRFGPVRLLRLSALLAAVGLLLAL--LAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAV 339
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 19-163 1.40e-06

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 50.27  E-value: 1.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  19 LANMFAINAAYPA---LQRELHASVTQLAWIGNIYMLGLTVVIPLGAWLAHRFGERRLLAASLLVFALGSAGAASAQSIG 95
Cdd:cd17323    9 FVVTFGSSIYSPAlpqIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIA 88

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 497581776  96 ALLASRLVQGLGGGLLIPVGQAMTYRAYPRETRARLTSIVMMVALLVPATSPALGGVIVDHASWRAVF 163
Cdd:cd17323   89 MLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIF 156
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 23-406 2.19e-06

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 49.51  E-value: 2.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  23 FAINAAYPALQRELHASVTQLAWIGNIYMLGLTVVIPLGAWLAHRFGERRLLAASLLVFALGSAGAASAQSIGALLASRL 102
Cdd:cd17489   13 YLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 103 VQGLGGGLLIPVGQAMTYRAYPRETRARLTSIVMMVALLVPATSPALGGVIVDHASWRAVFagmlalaalacvlalawlp 182
Cdd:cd17489   93 IHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLF------------------- 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 183 advsndaprpldaaglgLSAAGLIALLLGFTFASRRGAPmpaiaalaiacvaglayVRHARRSSAPLLDLALLSQPLLRV 262
Cdd:cd17489  154 -----------------IVAAVLALLALLLVFLVKDPPP-----------------VAAEEAEAGTRAFRRLVEKKVLPP 199

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 263 GVVIYLCVPGVFTGVNLIASLFLQnalgLSATQVGALMVPWSAASFAAIATTRRAFPLHGPRPLLACGIVIACIGVALLA 342
Cdd:cd17489  200 ALILFLASIAYGAISTFLPLYAAE----RGISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLS 275

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 497581776 343 TPLAAHEAgrMLAYAAMGFGASLCTSTSQSAAFLDVPADRMGEASALWNINRQLSFCLGSAVLG 406
Cdd:cd17489  276 FAGSPWML--LLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLG 337
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 6-164 5.00e-06

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 48.51  E-value: 5.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776    6 RIAAVYLLGFSIDLANMFAINAAYPALQRELHASVTQLAWIGNIYMLGLTVVIPLGAWLAHRFGERRLLAASLLVFALGS 85
Cdd:TIGR00895  17 RAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFT 96

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 497581776   86 AGAASAQSIGALLASRLVQGLGGGLLIPVGQAMTYRAYPRETRARLTSIVMMVALLVPATSPALGGVIVDHASWRAVFA 164
Cdd:TIGR00895  97 LLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFY 175
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
28-163 6.09e-06

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 48.37  E-value: 6.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  28 AYPALQRELHASVTQLAWIGNIYMLGLTVVIPLGAWLAHRFGERRLLAASLLVFALGSAGAASAQSIGALLASRLVQGLG 107
Cdd:PRK11102  13 ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLA 92

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 497581776 108 GGLLIPVGQAMTYRAYPRETRARLTSIVMMVALLVPATSPALGGVIVDHASWRAVF 163
Cdd:PRK11102  93 AAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIF 148
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
30-164 1.07e-05

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 47.56  E-value: 1.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  30 PALQRELHASVTQLAWIGNIYMLGLTVVIPLGAWLAHRFGERRLLAASLLVFALGSAGAASAQSIGALLASRLVQGLGGG 109
Cdd:COG2807   42 PEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIA 121

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 497581776 110 LLIPVGQAMTYRAYPREtRARLTSIVMMVALLVPATSPALGGVIVDHASWRAVFA 164
Cdd:COG2807  122 VGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALA 175
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 24-163 1.63e-05

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 46.81  E-value: 1.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  24 AINAAYPALQRELHASVTQLAWIGNIYMLGLTVVIPLGAWLAHRFGERRLLAASLLVFALGSAGAASAQSIGALLASRLV 103
Cdd:cd17365   17 VMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFL 96

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 104 QGLGGGLLIPVGQAMTYRAYPRETRARLTSIVMMVALLVPATSPALGGVIVDHASWRAVF 163
Cdd:cd17365   97 TGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVF 156
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 35-412 6.72e-05

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 44.91  E-value: 6.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  35 ELHASVTQLAWIGNIYMLGLTVVIPLGAWLAHRFGERRLLAAS-----LLVFALGSAGAASAQSIGALLASRLVQGLGGG 109
Cdd:cd06173   28 QLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILAdllraLLAAVLALLALLGSLSLWLLLVLAFLLGIASA 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 110 LLIPVGQAMTYRAYPRETRARLTSIVMMVALLVPATSPALGGVIVDHASWRAVFAgmlalaalacvlalawlpadvsnda 189
Cdd:cd06173  108 FFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFA------------------------- 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 190 prpLDAAGLGLSAAGLIALllgftfasRRGAPMPAIAALAIACVAGLAYVRHARRSsaplldlallsqPLLRVGVVIYLC 269
Cdd:cd06173  163 ---INALSFLLSALLLLFI--------RRPPPAAPGESSSLLLRDLREGLRYLRRS------------PLLRLLLLALAL 219

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 270 VPGVFTGVNLIASLFLQNALGLSATQVGALMVPWSAASFAAIATTRRAFPLHGPRPLLAcgIVIACIGVALLATPLAAHE 349
Cdd:cd06173  220 FALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLL--IGALLLGLALLVLGLSPSL 297

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 497581776 350 AGRMLAYAAMGFGASLCTSTSQSAAFLDVPADRMGEASALWNINRQLSFCLGSAVLGSALNFL 412
Cdd:cd06173  298 WLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADAL 360
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 4-159 9.38e-05

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 44.97  E-value: 9.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776    4 RSRIAAVYLLGFSI--DLANMFAINAAYPALQRELHASVTQLAWIGNIYMLGLTVVIPLGAWLAHRFGERRLLAASLLVF 81
Cdd:TIGR01299 163 RFQWALFFVLGLALmaDGVEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVN 242

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 497581776   82 ALGSAGAASAQSIGALLASRLVQGLGGGLLIPVGQAMTYRAYPRETRARLTSIVMMVALLVPATSPALGGVIVDHASW 159
Cdd:TIGR01299 243 GFFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIGGIYAAAMAWAIIPHYGW 320
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 11-166 1.51e-04

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 43.72  E-value: 1.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  11 YLLGFSIDLANMFAINAAYPAL----QRELHASVTQLAWIGNIYMLGLTVVIPLGAWLAHRFGERRLLAASLLVFALGSA 86
Cdd:cd17325  201 LLALFLAIFVLAFAFGALEPFLplyaAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALL 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  87 GAASAQSIGALLASRLVQGLGGGLLIPVGQAMTYRAYPRETRARLTSIVMMVALLVPATSPALGGVIVDHASWRAVFAGM 166
Cdd:cd17325  281 LLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAA 360
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
30-166 1.62e-04

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 43.86  E-value: 1.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  30 PALQRELHASVTQLAWIGNIYMLGLTVVIPLGAWLAHRFGERRLLAASLLVFALGSAGAASAQSIGALLASRLVQGLGGG 109
Cdd:PRK10473  27 PRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGAG 106

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 497581776 110 LLIPVGQAMTYRAYPRETRARLTSIVMMVALLVPATSPALGGVIVDHASWRAVFAGM 166
Cdd:PRK10473 107 CCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTM 163
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
 11-159 1.79e-04

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 43.76  E-value: 1.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  11 YLLGFSI--DLANMFAINAAYPALQRELHASVTQLAWIGNIYMLGLTVVIPLGAWLAHRFGERRLLAASLLVFALGSAGA 88
Cdd:cd17438    2 FVLGLALmaDGVEVFVVGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLS 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 497581776  89 ASAQSIGALLASRLVQGLGGGLLIPVGQAMTYRAYPRETRARLTSIVMMVALLVPATSPALGGVIVDHASW 159
Cdd:cd17438   82 SFVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIGGLYASAMAWSIIPHYGW 152
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 24-410 3.43e-04

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 43.00  E-value: 3.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  24 AINAAYPALQRELHASvTQLAWIGNIYMLGLTVVIPLGAWLAHRFGERRLLAASLLVFALGSAGAASAQSIGALLASRLV 103
Cdd:cd06179   16 LPAAVLPFIVADLGPS-SNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQAL 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 104 qGLGGGLLIPVGQAMTYRAYPRETRARLTSIVMMVALLVPATSPALGGVIV--DHASWRAVF---AGMLALAALACVLAL 178
Cdd:cd06179   95 -IGIGAGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVeaNAAGWRWIFyinAIFNALALILLFFFY 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 179 AWLPADVSNDAP-----RPLDAAGLGLSAAGLIALLLGFTFASRRGAPMPA--IAALAIACVAGLA-YVRHARRSSAPLL 250
Cdd:cd06179  174 HPPPRPQLHGSStrqklKRLDWVGLFLLIAGLVLFLLGLSWGGNPYPWSSAhvIAPLVIGGVLLIAfGLYEWKGTKDGLL 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 251 DLALLSQPLLRVGVVIYLCVPG-VFTGVNLIASLFLQNALGLSATQVGALMVPWSAAS-FAAIATTRRAFPLHGPRPLLA 328
Cdd:cd06179  254 PPRLLFRGRNFALILIVAFVEGmIFYSLNIFWPQQISLLFTTDPLKAGLYQLPFGLGTlFGAILAGLLLTKIKHIKWQLV 333

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 329 CGIVIACIGVALLA--TPLAAHEAGRMLAYAAMGFGASLCTSTsqSAAFLDVPADRMGEASALWNINRQLSFCLGSAVLG 406
Cdd:cd06179  334 AGFVLFTAFLALLAliTPDNKALAIAFSVLAGIGIGGPLVLAI--VIVQLSVPPEDIGTASGLLGSARALGGAVGTAIFT 411


                 ....
gi 497581776 407 SALN 410
Cdd:cd06179  412 SILS 415
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
25-163 4.21e-04

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 42.62  E-value: 4.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  25 INAAYPALQRELHASVTQLAWIGNIYMLGLTVVIPLGAWLAHRFGERRLLAASLLVFALGSAGAASAQSIGALLASRLVQ 104
Cdd:PRK15402  32 IQPGMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQ 111

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 497581776 105 GLGGGLLIPVGQAMTYRAYPRETRARLTSIVMMVALLVPATSPALGGVIVDHASWRAVF 163
Cdd:PRK15402 112 GIGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALIHVLPWRGMF 170
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 2-163 4.29e-04

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 42.64  E-value: 4.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776   2 SARSRIAAVYLLGFSIDLANMF---AINAAYPALQRELHASVTQLAWIGNIYMLGLTVVIPLGAWLAHRFGERRLLAASL 78
Cdd:PRK11551   8 ASSSRLALTIGLCFLVALLEGLdlqSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSV 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  79 LVFALGSAGAASAQSIGALLASRLVQGLGGGLLIPVGQAMTYRAYPRETRARLTSIVMMVALLVPATSPALGGVIVDHAS 158
Cdd:PRK11551  88 ALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAA 167


                 ....*
gi 497581776 159 WRAVF 163
Cdd:PRK11551 168 WRHIF 172
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
196-411 9.99e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 41.43  E-value: 9.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 196 AGLGLSAAGLIALLLGFTFASRRGAPMPAIAALAIACVAGLAYVR------HARRSSAPLLDL--ALLSQPLLRVGVVIY 267
Cdd:COG2211  158 LGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFgtkerpVPEEEKVSLKESlkALLKNRPFLLLLLAY 237

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 268 LCVPGVFTGVNLIASLFLQNALGLSATQVGALMVPWSAASFAAIATTRRAFPLHGPRPLLACGIVIACIGVALLATPLAA 347
Cdd:COG2211  238 LLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPG 317

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 497581776 348 HEAGRMLAYAAMGFGASLCTSTSQS-------AAFLDVPADRMGEASALWNINRQLSFCLGSAVLGSALNF 411
Cdd:COG2211  318 NLWLLLVLAALAGIGLGAILVLPWAmladvvdYDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLAL 388
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 13-364 1.75e-03

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 40.36  E-value: 1.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  13 LGFSIDLANMFAINAAYPALQRELHASVTQLAWIGNIYMLGLTVVIPLGAWLAHRFGERRLLAASLLVFALGSAGAASAQ 92
Cdd:cd17371    6 LGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQ 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  93 SIGALLASRLVQGLGGGLLIPVGQAMTYRAYPRETRARLTSIVMMV----ALLVPATSPALGGVIVDHASWRAVFAgmla 168
Cdd:cd17371   86 NYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGwavgWLLATLLAALLFPLLPPEIAWRVLFL---- 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 169 laalacvlalawlpadvsndaprpldaagLGLSAAGLIALLlgftfasRRGAPMPAIAALAiacvaglayvRHARRSSAP 248
Cdd:cd17371  162 -----------------------------LGALPALLVLFI-------RRFVKEPPQWQAA----------RAARRHFAD 195

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 249 L-LDLALLSQPLLRVGVVIYL---CVPGVFTGVNLIASLFLQNALGLSATQVGALMVPWSAASFAAIATTRRAFPLHGPR 324
Cdd:cd17371  196 RpSLRELFSPPLLRTTLLASLlatGALGGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRR 275

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 497581776 325 PLLACGIVIACIGVaLLATPLAAHEAGRMLAYAAMGFGAS 364
Cdd:cd17371  276 NNFALFALGSAISI-LLYFFLPLSPTLILILGFPLGFFAS 314
PRK15403 PRK15403
multidrug efflux MFS transporter MdtM;
34-164 3.24e-03

multidrug efflux MFS transporter MdtM;


Pssm-ID: 237958 [Multi-domain]  Cd Length: 413  Bit Score: 39.81  E-value: 3.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  34 RELHASVTQLAWIGNIYMLGLTVVIPLGAWLAHRFGERRLLAASLLVFALGSAGAASAQSIGALLASRLVQGLGGGLLIP 113
Cdd:PRK15403  44 RDFNADVSLAPASVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIAT 123

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 497581776 114 VGQAMTYRAYPRETRARLTSIVMMVALLVPATSPALGGVIVDHASWRAVFA 164
Cdd:PRK15403 124 VGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAALMHFVHWKVLFA 174
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 61-163 3.56e-03

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 39.52  E-value: 3.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  61 GAWLAHRFGERRLLAASLLV--FALGSAGAASAQSIGALLASRLVQGLGGGLLIPVGQAMTYRAYPRETRARLTSIVMMV 138
Cdd:cd17318   76 GGYLAEKYGAKRVLGYSILItaLLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSG 155

                         90       100
                 ....*....|....*....|....*
gi 497581776 139 ALLVPATSPALGGVIVDHASWRAVF 163
Cdd:cd17318  156 SQFGTVIAMPLSGFLCESLGWPSIF 180
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 9-163 3.79e-03

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 39.46  E-value: 3.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776   9 AVYLLGFSIDLANMFAINAAYPALQRELHASVTQLAWIGNIYMLGLTVVIPLGAWLAHRFGERRLLAASLLV--FALGSA 86
Cdd:cd17380    2 ILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALwsLATLLT 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 497581776  87 GAASAQSIGALLASRLVQGLGGGLLIPVGQAMTYRAYPRETRARLTSIVMMVALLVPATSPALGGVIVDHASWRAVF 163
Cdd:cd17380   82 PLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVF 158
MFS_MosC_like cd17393
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ...
 199-374 5.02e-03

Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340951 [Multi-domain]  Cd Length: 373  Bit Score: 39.16  E-value: 5.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 199 GLSAAGLIALLLGFTFASRRGAPMPAIAALAIACVAGLAYVRHARRSSAPLLDLALLSQPLLRVGVVIYLCVPGVFT--- 275
Cdd:cd17393  135 GLAGALLGAAAIGAGVSPGVHLLAAAVLLLLAALVAIRALLPGTGEAAEDRPDGAGKPGFLLPNRLLLLLGLLALAAala 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776 276 --GVNLIASLFLQNALGLSATQVGALMVPWSAASFAAIATTRRAFPLHGPRPLLACGIVIACIGVALLAtpLAAHEAGRM 353
Cdd:cd17393  215 egAAADWSALYLRDVLGASAALAALGYAVFSLAMTVGRLFGDRLVDRFGDVAVLRAGALLAALGLLLAL--LAPSVWVAL 292

                        170       180
                 ....*....|....*....|.
gi 497581776 354 LAYAAMGFGASLCTSTSQSAA 374
Cdd:cd17393  293 AGFALMGLGLSVVVPLAFSAA 313
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
 11-159 6.18e-03

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 38.86  E-value: 6.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497581776  11 YLLGFSI--DLANMFAINAAYPALQRELHASVTQLAWIGNIYMLGLTVVIPLGAWLAHRFGERRLLAASLLVFALGSAGA 88
Cdd:cd17439    2 FVLGLALmaDGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFS 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 497581776  89 ASAQSIGALLASRLVQGLGGGLLIPVGQAMTYRAYPRETRARLTSIVMMVALLVPATSPALGGVIVDHASW 159
Cdd:cd17439   82 SFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGW 152
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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