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Conserved domains on  [gi|497557729|ref|WP_009871913|]
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ATP-binding protein [Chlamydia trachomatis]

Protein Classification

ATP-binding protein( domain architecture ID 10005496)

ATP-binding protein with a histidine kinase-like ATPase domain, similar to serine/threonine-protein kinase BtrW, which phosphorylates and inactivates its specific antagonist protein BtrV and may function as a negative regulator of sigma-B activity

Gene Ontology:  GO:0005524|GO:0016787
PubMed:  16077112|12354223

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
51-140 3.12e-21

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


:

Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 82.65  E-value: 3.12e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497557729  51 NIITHAYKGLPStGWIRILCTETPDALLVRITDHGPAFNPitaspdiMRLDLPIEQRRIGGLGIFLAKYSVDVFDYERVN 130
Cdd:COG2172   45 NAVRHAYGGDPD-GPVEVELELDPDGLEIEVRDEGPGFDP-------EDLPDPYSTLAEGGRGLFLIRRLMDEVEYESDP 116

                         90
                 ....*....|
gi 497557729 131 DTNVVTLTLY 140
Cdd:COG2172  117 GGTTVRLVKR 126
 
Name Accession Description Interval E-value
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
51-140 3.12e-21

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 82.65  E-value: 3.12e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497557729  51 NIITHAYKGLPStGWIRILCTETPDALLVRITDHGPAFNPitaspdiMRLDLPIEQRRIGGLGIFLAKYSVDVFDYERVN 130
Cdd:COG2172   45 NAVRHAYGGDPD-GPVEVELELDPDGLEIEVRDEGPGFDP-------EDLPDPYSTLAEGGRGLFLIRRLMDEVEYESDP 116

                         90
                 ....*....|
gi 497557729 131 DTNVVTLTLY 140
Cdd:COG2172  117 GGTTVRLVKR 126
HATPase_c_2 pfam13581
Histidine kinase-like ATPase domain;
10-138 3.70e-19

Histidine kinase-like ATPase domain;


Pssm-ID: 433327 [Multi-domain]  Cd Length: 127  Bit Score: 77.33  E-value: 3.70e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497557729   10 FPATLQDLYPMLDFVKRAGVHCNCTQKKLSKLELACEELLLNIITHAYKGLPsTGWIRILCTETPDALLVRITDHGPAFN 89
Cdd:pfam13581   1 FPADPEQLRAARRVLEAVLRRAGLPEELLDEVELAVGEACTNAVEHAYREGP-EGPVEVRLTSDGGGLVVTVADSGPPFD 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 497557729   90 PITASPDimRLDLPIEQRRIGGLGIFLAKYSVDVFDYERVNDTNVVTLT 138
Cdd:pfam13581  80 PLTLPPP--DLEEPDEDRKEGGRGLALIRGLMDDVEYTRGGEGNTVRMR 126
HATPase_RsbW-like cd16936
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ...
 51-139 6.03e-16

Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.


Pssm-ID: 340413 [Multi-domain]  Cd Length: 91  Bit Score: 68.06  E-value: 6.03e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497557729  51 NIITHAYKGLPStGWIRILCTETPDALLVRITDHGPAFNPI-TASPDIMrldlpieqRRIGGLGIFLAKYSVDVFDYERV 129
Cdd:cd16936   11 NAVRHAYRHDGP-GPVRLELDLDPDRLRVEVTDSGPGFDPLrPADPDAG--------LREGGRGLALIRALMDEVGYRRT 81

                         90
                 ....*....|
gi 497557729 130 NDTNVVTLTL 139
Cdd:cd16936   82 PGGKTVWLEL 91
PRK04069 PRK04069
serine-protein kinase RsbW; Provisional
 51-142 3.06e-06

serine-protein kinase RsbW; Provisional


Pssm-ID: 235217 [Multi-domain]  Cd Length: 161  Bit Score: 44.15  E-value: 3.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497557729  51 NIITHAYKGlPSTGWIRILCTETPDALLVRITDHGPAFN---------PITASPdimrldlPIEQRRIGGLGIFLAKYSV 121
Cdd:PRK04069  53 NAVQHAYKE-DEVGEIHIRFEIYEDRLEIVVADNGVSFDyetlksklgPYDISK-------PIEDLREGGLGLFLIETLM 124

                         90       100
                 ....*....|....*....|..
gi 497557729 122 DvfDYERVNDTNV-VTLTLYTK 142
Cdd:PRK04069 125 D--DVTVYKDSGVtVSMTKYIN 144
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 51-90 9.87e-03

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 33.78  E-value: 9.87e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 497557729    51 NIITHAYKGLPSTGWIRILCTETPDALLVRITDHGPAFNP 90
Cdd:smart00387  12 NLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPP 51
 
Name Accession Description Interval E-value
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
51-140 3.12e-21

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 82.65  E-value: 3.12e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497557729  51 NIITHAYKGLPStGWIRILCTETPDALLVRITDHGPAFNPitaspdiMRLDLPIEQRRIGGLGIFLAKYSVDVFDYERVN 130
Cdd:COG2172   45 NAVRHAYGGDPD-GPVEVELELDPDGLEIEVRDEGPGFDP-------EDLPDPYSTLAEGGRGLFLIRRLMDEVEYESDP 116

                         90
                 ....*....|
gi 497557729 131 DTNVVTLTLY 140
Cdd:COG2172  117 GGTTVRLVKR 126
HATPase_c_2 pfam13581
Histidine kinase-like ATPase domain;
10-138 3.70e-19

Histidine kinase-like ATPase domain;


Pssm-ID: 433327 [Multi-domain]  Cd Length: 127  Bit Score: 77.33  E-value: 3.70e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497557729   10 FPATLQDLYPMLDFVKRAGVHCNCTQKKLSKLELACEELLLNIITHAYKGLPsTGWIRILCTETPDALLVRITDHGPAFN 89
Cdd:pfam13581   1 FPADPEQLRAARRVLEAVLRRAGLPEELLDEVELAVGEACTNAVEHAYREGP-EGPVEVRLTSDGGGLVVTVADSGPPFD 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 497557729   90 PITASPDimRLDLPIEQRRIGGLGIFLAKYSVDVFDYERVNDTNVVTLT 138
Cdd:pfam13581  80 PLTLPPP--DLEEPDEDRKEGGRGLALIRGLMDDVEYTRGGEGNTVRMR 126
HATPase_RsbW-like cd16936
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ...
 51-139 6.03e-16

Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.


Pssm-ID: 340413 [Multi-domain]  Cd Length: 91  Bit Score: 68.06  E-value: 6.03e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497557729  51 NIITHAYKGLPStGWIRILCTETPDALLVRITDHGPAFNPI-TASPDIMrldlpieqRRIGGLGIFLAKYSVDVFDYERV 129
Cdd:cd16936   11 NAVRHAYRHDGP-GPVRLELDLDPDRLRVEVTDSGPGFDPLrPADPDAG--------LREGGRGLALIRALMDEVGYRRT 81

                         90
                 ....*....|
gi 497557729 130 NDTNVVTLTL 139
Cdd:cd16936   82 PGGKTVWLEL 91
PRK04069 PRK04069
serine-protein kinase RsbW; Provisional
 51-142 3.06e-06

serine-protein kinase RsbW; Provisional


Pssm-ID: 235217 [Multi-domain]  Cd Length: 161  Bit Score: 44.15  E-value: 3.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497557729  51 NIITHAYKGlPSTGWIRILCTETPDALLVRITDHGPAFN---------PITASPdimrldlPIEQRRIGGLGIFLAKYSV 121
Cdd:PRK04069  53 NAVQHAYKE-DEVGEIHIRFEIYEDRLEIVVADNGVSFDyetlksklgPYDISK-------PIEDLREGGLGLFLIETLM 124

                         90       100
                 ....*....|....*....|..
gi 497557729 122 DvfDYERVNDTNV-VTLTLYTK 142
Cdd:PRK04069 125 D--DVTVYKDSGVtVSMTKYIN 144
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 51-90 9.87e-03

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 33.78  E-value: 9.87e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 497557729    51 NIITHAYKGLPSTGWIRILCTETPDALLVRITDHGPAFNP 90
Cdd:smart00387  12 NLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPP 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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