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Conserved domains on  [gi|495979243|ref|WP_008703822|]
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MULTISPECIES: helix-turn-helix transcriptional regulator [Bacillota]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 10007659)

helix-turn-helix (HTH) domain-containing protein with an XRE (Xenobiotic Response Element) family HTH domain, binds DNA and may function as a transcriptional regulator

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|2644244|8831795
SCOP:  4000362

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YozG COG3655
DNA-binding transcriptional regulator, XRE family [Transcription];
5-69 1.05e-21

DNA-binding transcriptional regulator, XRE family [Transcription];


:

Pssm-ID: 442872 [Multi-domain]  Cd Length: 69  Bit Score: 79.42  E-value: 1.05e-21
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 495979243  5 YNKLWKLLIDKGMKKSQLREAVGASKSTFAKL--GKNENVTLPVLLNICEYLECDFGDIMEAVPENE 69
Cdd:COG3655   3 YVKLDELLAERGMTKKELAEATGISRATLSRLknGKAKAVRLDTLEKICKALDCQPGDLLEYVPDEE 69
 
Name Accession Description Interval E-value
YozG COG3655
DNA-binding transcriptional regulator, XRE family [Transcription];
5-69 1.05e-21

DNA-binding transcriptional regulator, XRE family [Transcription];


Pssm-ID: 442872 [Multi-domain]  Cd Length: 69  Bit Score: 79.42  E-value: 1.05e-21
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 495979243  5 YNKLWKLLIDKGMKKSQLREAVGASKSTFAKL--GKNENVTLPVLLNICEYLECDFGDIMEAVPENE 69
Cdd:COG3655   3 YVKLDELLAERGMTKKELAEATGISRATLSRLknGKAKAVRLDTLEKICKALDCQPGDLLEYVPDEE 69
HTH_26 pfam13443
Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to ...
 7-67 1.68e-18

Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433211 [Multi-domain]  Cd Length: 63  Bit Score: 71.03  E-value: 1.68e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 495979243   7 KLWKLLIDKGMKKSQLREAVGASKSTFAKL--GKNENVTLPVLLNICEYLECDFGDIMEAVPE 67
Cdd:pfam13443  1 KLRKLMADRGISKSDLARATGISRATLSRLrkGKPKRVSLDTLDKICDALGCQPGDLLEYVPD 63
 
Name Accession Description Interval E-value
YozG COG3655
DNA-binding transcriptional regulator, XRE family [Transcription];
5-69 1.05e-21

DNA-binding transcriptional regulator, XRE family [Transcription];


Pssm-ID: 442872 [Multi-domain]  Cd Length: 69  Bit Score: 79.42  E-value: 1.05e-21
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 495979243  5 YNKLWKLLIDKGMKKSQLREAVGASKSTFAKL--GKNENVTLPVLLNICEYLECDFGDIMEAVPENE 69
Cdd:COG3655   3 YVKLDELLAERGMTKKELAEATGISRATLSRLknGKAKAVRLDTLEKICKALDCQPGDLLEYVPDEE 69
HTH_26 pfam13443
Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to ...
 7-67 1.68e-18

Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433211 [Multi-domain]  Cd Length: 63  Bit Score: 71.03  E-value: 1.68e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 495979243   7 KLWKLLIDKGMKKSQLREAVGASKSTFAKL--GKNENVTLPVLLNICEYLECDFGDIMEAVPE 67
Cdd:pfam13443  1 KLRKLMADRGISKSDLARATGISRATLSRLrkGKPKRVSLDTLDKICDALGCQPGDLLEYVPD 63
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
6-63 3.50e-04

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 34.82  E-value: 3.50e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 495979243  6 NKLWKLLIDKGMKKSQLREAVGASKSTFAKLGKNE-NVTLPVLLNICEYLECDFGDIME 63
Cdd:COG1476   7 NRLKELRKERGLTQEELAELLGVSRQTISAIENGKyNPSLELALKIARALGVSLEELFS 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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