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Conserved domains on  [gi|495401436|ref|WP_008126135|]
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OmpA family protein [Hoylesella timonensis]

Protein Classification

OmpA family protein( domain architecture ID 10163224)

OmpA family membrane protein acts as a porin with low permeability that allows slow penetration of small solutes; may function in peptidoglycan binding

CATH:  3.30.1330.60
Gene Ontology:  GO:0016020|GO:0009279|GO:0015288|GO:0042834
PubMed:  17559395

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
OmpA_C-like cd07185
Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; ...
 278-361 2.23e-21

Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.


:

Pssm-ID: 143586 [Multi-domain]  Cd Length: 106  Bit Score: 87.99  E-value: 2.23e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495401436 278 TVLFRQGQSVVDRSQMPNIELIANYMKNHKSATVTIKGYASPEGPTELNQRLSENRAKNVKNLLVDKYrIAPNRLKTVGM 357
Cdd:cd07185    3 TIYFDFGSAELTPEAKPLLDKLAEVLKKNPDAKIRIEGHTDSRGSDAYNQELSERRAEAVADYLVSKG-VDASRITAVGY 81


                 ....
gi 495401436 358 GETN 361
Cdd:cd07185   82 GESR 85
CwlO1 super family cl25603
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 219-263 2.67e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


The actual alignment was detected with superfamily member COG3883:

Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 39.43  E-value: 2.67e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 495401436 219 QSEIDGLNAQINSLRNDLSGKNAQLTDKDRQISDLQKALDDCNKR 263
Cdd:COG3883   36 QAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAE 80
GlpG super family cl42100
Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein ...
 97-134 6.15e-03

Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG0705:

Pssm-ID: 440469 [Multi-domain]  Cd Length: 189  Bit Score: 37.53  E-value: 6.15e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 495401436  97 LLGTVNLSNWFGGYPGEPRGFEVVGLFGY-----GWGHLFGNT 134
Cdd:COG0705   21 LLLGGELLNWLALVPARLLLGELWRLLTSmflhgGFLHLLFNM 63
 
Name Accession Description Interval E-value
OmpA_C-like cd07185
Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; ...
 278-361 2.23e-21

Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.


Pssm-ID: 143586 [Multi-domain]  Cd Length: 106  Bit Score: 87.99  E-value: 2.23e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495401436 278 TVLFRQGQSVVDRSQMPNIELIANYMKNHKSATVTIKGYASPEGPTELNQRLSENRAKNVKNLLVDKYrIAPNRLKTVGM 357
Cdd:cd07185    3 TIYFDFGSAELTPEAKPLLDKLAEVLKKNPDAKIRIEGHTDSRGSDAYNQELSERRAEAVADYLVSKG-VDASRITAVGY 81


                 ....
gi 495401436 358 GETN 361
Cdd:cd07185   82 GESR 85
OmpA COG2885
Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall ...
 218-361 7.16e-21

Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442131 [Multi-domain]  Cd Length: 294  Bit Score: 91.77  E-value: 7.16e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495401436 218 DQSEIDGLNAQINSLRNDLSGKNAQLTDKDRQISDLQKALDDCNKRKAYVKPA--TATNLQPTVLFRQGQSVVDRSQMPN 295
Cdd:COG2885  126 AGAAAALGALGASAAAAAAALAAAKALGDSAAAALDAAAKAEAAAAAAALLPAavAEVVLLSNVYFDFDSAELTPEAKAA 205

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 495401436 296 IELIANYMKNHKSATVTIKGYASPEGPTELNQRLSENRAKNVKNLLVDKyRIAPNRLKTVGMGETN 361
Cdd:COG2885  206 LDELAALLKENPDLRIEIEGHTDSRGSDAYNLALSERRAEAVKDYLVSK-GIPASRITAVGYGESR 270
OmpA pfam00691
OmpA family; The Pfam entry also includes MotB and related proteins which are not included in ...
 281-366 3.91e-14

OmpA family; The Pfam entry also includes MotB and related proteins which are not included in the Prosite family.


Pssm-ID: 425825 [Multi-domain]  Cd Length: 95  Bit Score: 67.38  E-value: 3.91e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495401436  281 FRQGQSVVDRSQMPNIELIANYMK-NHKSATVTIKGYASPEGPTELNQRLSENRAKNVKNLLVDKYrIAPNRLKTVGMGE 359
Cdd:pfam00691   1 FDPGSSQLTPKAKATLDEIADLLKfPELKNTITIEGHTDTVGSAAYNWELSQRRAEAVRRYLVNFG-VPPSRISVVGYGA 79


                  ....*..
gi 495401436  360 TNKLFKE 366
Cdd:pfam00691  80 TKPITDN 86
PRK10510 PRK10510
OmpA family lipoprotein;
299-361 6.30e-05

OmpA family lipoprotein;


Pssm-ID: 182507 [Multi-domain]  Cd Length: 219  Bit Score: 43.71  E-value: 6.30e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 495401436 299 IANYMKNHKSATVTIKGYASPEGPTELNQRLSENRAKNVKNLLVDKyRIAPNRLKTVGMGETN 361
Cdd:PRK10510 134 VAMVLKEYPKTAVNVVGYTDSTGSHDLNMRLSQQRADSVASALITQ-GVDASRIRTQGMGPAN 195
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 219-263 2.67e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 39.43  E-value: 2.67e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 495401436 219 QSEIDGLNAQINSLRNDLSGKNAQLTDKDRQISDLQKALDDCNKR 263
Cdd:COG3883   36 QAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAE 80
GlpG COG0705
Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein ...
 97-134 6.15e-03

Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440469 [Multi-domain]  Cd Length: 189  Bit Score: 37.53  E-value: 6.15e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 495401436  97 LLGTVNLSNWFGGYPGEPRGFEVVGLFGY-----GWGHLFGNT 134
Cdd:COG0705   21 LLLGGELLNWLALVPARLLLGELWRLLTSmflhgGFLHLLFNM 63
 
Name Accession Description Interval E-value
OmpA_C-like cd07185
Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; ...
 278-361 2.23e-21

Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.


Pssm-ID: 143586 [Multi-domain]  Cd Length: 106  Bit Score: 87.99  E-value: 2.23e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495401436 278 TVLFRQGQSVVDRSQMPNIELIANYMKNHKSATVTIKGYASPEGPTELNQRLSENRAKNVKNLLVDKYrIAPNRLKTVGM 357
Cdd:cd07185    3 TIYFDFGSAELTPEAKPLLDKLAEVLKKNPDAKIRIEGHTDSRGSDAYNQELSERRAEAVADYLVSKG-VDASRITAVGY 81


                 ....
gi 495401436 358 GETN 361
Cdd:cd07185   82 GESR 85
OmpA COG2885
Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall ...
 218-361 7.16e-21

Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442131 [Multi-domain]  Cd Length: 294  Bit Score: 91.77  E-value: 7.16e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495401436 218 DQSEIDGLNAQINSLRNDLSGKNAQLTDKDRQISDLQKALDDCNKRKAYVKPA--TATNLQPTVLFRQGQSVVDRSQMPN 295
Cdd:COG2885  126 AGAAAALGALGASAAAAAAALAAAKALGDSAAAALDAAAKAEAAAAAAALLPAavAEVVLLSNVYFDFDSAELTPEAKAA 205

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 495401436 296 IELIANYMKNHKSATVTIKGYASPEGPTELNQRLSENRAKNVKNLLVDKyRIAPNRLKTVGMGETN 361
Cdd:COG2885  206 LDELAALLKENPDLRIEIEGHTDSRGSDAYNLALSERRAEAVKDYLVSK-GIPASRITAVGYGESR 270
OmpA pfam00691
OmpA family; The Pfam entry also includes MotB and related proteins which are not included in ...
 281-366 3.91e-14

OmpA family; The Pfam entry also includes MotB and related proteins which are not included in the Prosite family.


Pssm-ID: 425825 [Multi-domain]  Cd Length: 95  Bit Score: 67.38  E-value: 3.91e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495401436  281 FRQGQSVVDRSQMPNIELIANYMK-NHKSATVTIKGYASPEGPTELNQRLSENRAKNVKNLLVDKYrIAPNRLKTVGMGE 359
Cdd:pfam00691   1 FDPGSSQLTPKAKATLDEIADLLKfPELKNTITIEGHTDTVGSAAYNWELSQRRAEAVRRYLVNFG-VPPSRISVVGYGA 79


                  ....*..
gi 495401436  360 TNKLFKE 366
Cdd:pfam00691  80 TKPITDN 86
PRK10510 PRK10510
OmpA family lipoprotein;
299-361 6.30e-05

OmpA family lipoprotein;


Pssm-ID: 182507 [Multi-domain]  Cd Length: 219  Bit Score: 43.71  E-value: 6.30e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 495401436 299 IANYMKNHKSATVTIKGYASPEGPTELNQRLSENRAKNVKNLLVDKyRIAPNRLKTVGMGETN 361
Cdd:PRK10510 134 VAMVLKEYPKTAVNVVGYTDSTGSHDLNMRLSQQRADSVASALITQ-GVDASRIRTQGMGPAN 195
motB PRK08457
flagellar motor protein MotB; Reviewed
 271-375 1.01e-04

flagellar motor protein MotB; Reviewed


Pssm-ID: 181435 [Multi-domain]  Cd Length: 257  Bit Score: 43.55  E-value: 1.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495401436 271 TATNLQPTVLFRQGQSVVDRSQM----PNIELIANYMKnhKSATVTIKGYA--SPEGPTEL--NQRLSENRAKNVKNLLV 342
Cdd:PRK08457 116 IALKLPSKLLFENGSAEIINADMmdylKRIAKIITKLP--KQVKINVRGYTdnSPLNKSRYkdHYELAAARAYNVMKVLI 193

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 495401436 343 dKYRIAPNRLKTVGMGETN------KLFKELDFNRVATF 375
Cdd:PRK08457 194 -QYGINPNRLSFSSYGSNNpiapndSLENRLKNNRVEIF 231
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 219-263 2.67e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 39.43  E-value: 2.67e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 495401436 219 QSEIDGLNAQINSLRNDLSGKNAQLTDKDRQISDLQKALDDCNKR 263
Cdd:COG3883   36 QAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAE 80
MotB COG1360
Flagellar motor protein MotB [Cell motility];
279-360 3.65e-03

Flagellar motor protein MotB [Cell motility];


Pssm-ID: 440971 [Multi-domain]  Cd Length: 174  Bit Score: 37.90  E-value: 3.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495401436 279 VLFRQGQSVVDRSQMPNIELIANYMKNHKSAtVTIKG------YASPEGPTelNQRLSENRAKNVKNLLVDkYRIAPNRL 352
Cdd:COG1360   61 VLFDSGSAELTPEGRELLDKIAAVLAEVPNR-IRVEGhtdnvpISTARFPS--NWELSAARAAAVVRYLIE-GGVPPERL 136


                 ....*...
gi 495401436 353 KTVGMGET 360
Cdd:COG1360  137 SAVGYGDT 144
PRK10808 PRK10808
outer membrane protein A; Reviewed
 275-361 4.23e-03

outer membrane protein A; Reviewed


Pssm-ID: 236764 [Multi-domain]  Cd Length: 351  Bit Score: 38.90  E-value: 4.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495401436 275 LQPTVLFR--------QGQSVVDR--SQMPNIelianymkNHKSATVTIKGYASPEGPTELNQRLSENRAKNVKNLLVDK 344
Cdd:PRK10808 222 LKSDVLFNfnkatlkpEGQQALDQlySQLSNL--------DPKDGSVVVLGYTDRIGSDAYNQGLSEKRAQSVVDYLVSK 293

                         90
                 ....*....|....*..
gi 495401436 345 yRIAPNRLKTVGMGETN 361
Cdd:PRK10808 294 -GIPADKISARGMGKSN 309
GlpG COG0705
Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein ...
 97-134 6.15e-03

Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440469 [Multi-domain]  Cd Length: 189  Bit Score: 37.53  E-value: 6.15e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 495401436  97 LLGTVNLSNWFGGYPGEPRGFEVVGLFGY-----GWGHLFGNT 134
Cdd:COG0705   21 LLLGGELLNWLALVPARLLLGELWRLLTSmflhgGFLHLLFNM 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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