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Conserved domains on  [gi|493793808|ref|WP_006741909|]
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Fe(3+)-hydroxamate ABC transporter permease FhuB [Vibrio antiquarius]

Protein Classification

iron ABC transporter permease( domain architecture ID 11484808)

iron ABC transporter permease is the transmembrane subunit (TM) found in a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter involved in the import of iron and iron-containing compounds

Gene Ontology:  GO:0022857|GO:0006826|GO:0043190|GO:0140359|GO:0042626|GO:0016020
PubMed:  15574383|25750732|24638992|18535149|17723295
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
1-655 0e+00

Fe(3+)-hydroxamate ABC transporter permease FhuB;


:

Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 626.87  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808   1 MRTKHYIGYLALITLLSVFSLQIDTNLSLFEQWQLLTKPEvASEFRDVFFTQAQLPRLSITLLVGAMLGLTGSLMQQLTQ 80
Cdd:PRK10577  10 ARLPALLLALLLLLALALTLTQLSAALPLSQWLQALWGPD-ADDLEQLLLHYSRLPRLAIALLVGAALGLAGALLQQVLR 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808  81 NNLTSPLTLGTSSGAWLALVVVNIWFVDWVADYSALAAMAGALVAFGLIVSIAGVRNMTGLPLVVSGMVINILLGSIATA 160
Cdd:PRK10577  89 NPLASPTTLGVAAGAQLALVLATLFAPALLALASQLAAFAGGLLAAALVFALAGGKRLSPLRLVLAGMVVSLYLGALTTL 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 161 IIILNAQFAQNIFMWGAGDLSQYSWDWFEWLLPRCAIAIVILIVAPRILTLMKLGQEGAAARGLAVLPAFGTLMVMGIWL 240
Cdd:PRK10577 169 LLLFNEQYLQGLFLWGAGSLAQNDWSGVQRLLPRLLVGLLLLLLLARPLTLLGLGDDVARSLGLAVSLTRLAALALAVLL 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 241 VSASITAVGIISFIGLLTPNIARAMGARTPRDELISSMLLGAMLLIITDSAAISLSLWLEETIPSGVAAAAIGAPALIWF 320
Cdd:PRK10577 249 SAAVVSAVGPIGFIGLAAPNLARLLGARRLRARLPLSPLIGALLLLLTDQLVRLLAGVGGELLPTGAVTALIGAPLLLWL 328

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 321 TRKKLTATDQLNLSMSQGKTALSKRA---VCSIALFSLVGILAYSFVTHGINGIQWSVP--GEFQWQLRWPRMLTALSVG 395
Cdd:PRK10577 329 LPRLRSAQSAPAMSAGDRVAARRRRVlawLLALGLLLLLALVVALSFGRDAHGWNWLSGqlLDALLPLRLPRLLAALLAG 408

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 396 IALSVAGIILQRIVYNPLASPDILGVSSGATFAIITTGVIAGSLLSAFNWGIAFFGSMSVLMLLLIIGKRSHFNPSNFVL 475
Cdd:PRK10577 409 AMLAVAGTLLQRLTRNPLASPEVLGISSGAGLGVVLALFLVPGAGFGWLLAAALLGALAALALILLLARRGGFAPERLLL 488

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 476 SGIALTALLEALVQFSLAQGSGDSYKILLWLTGSIYRVTAGTALMLCLAIIVLLTAVFAISRWLTLISIGRQFSNARGLN 555
Cdd:PRK10577 489 TGIALSALFTALIQLLLASGDPRAAQLLTWLSGSTYGVTWAQALPLLIVAVLLLALALLLRRWLDLLPLGDDTARALGLP 568

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 556 PTVANTLMLTIVALLCAFSTATVGPISFVGLVAPHMAMMLGARKVKEQLSVGALVGATLMLWADWLGQIAIYPSQVAAGT 635
Cdd:PRK10577 569 VTRARLALLLLAALLTAAATATVGPLSFVGLMAPHLARMLGGRRARPQLVLAALLGALLMVLADWLGRTLLFPYQIPAGL 648

                        650       660
                 ....*....|....*....|
gi 493793808 636 LVAILGSTYFLFLMLKSKFS 655
Cdd:PRK10577 649 LAALIGAPYFLWLLRRSRRR 668
 
Name Accession Description Interval E-value
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
1-655 0e+00

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 626.87  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808   1 MRTKHYIGYLALITLLSVFSLQIDTNLSLFEQWQLLTKPEvASEFRDVFFTQAQLPRLSITLLVGAMLGLTGSLMQQLTQ 80
Cdd:PRK10577  10 ARLPALLLALLLLLALALTLTQLSAALPLSQWLQALWGPD-ADDLEQLLLHYSRLPRLAIALLVGAALGLAGALLQQVLR 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808  81 NNLTSPLTLGTSSGAWLALVVVNIWFVDWVADYSALAAMAGALVAFGLIVSIAGVRNMTGLPLVVSGMVINILLGSIATA 160
Cdd:PRK10577  89 NPLASPTTLGVAAGAQLALVLATLFAPALLALASQLAAFAGGLLAAALVFALAGGKRLSPLRLVLAGMVVSLYLGALTTL 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 161 IIILNAQFAQNIFMWGAGDLSQYSWDWFEWLLPRCAIAIVILIVAPRILTLMKLGQEGAAARGLAVLPAFGTLMVMGIWL 240
Cdd:PRK10577 169 LLLFNEQYLQGLFLWGAGSLAQNDWSGVQRLLPRLLVGLLLLLLLARPLTLLGLGDDVARSLGLAVSLTRLAALALAVLL 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 241 VSASITAVGIISFIGLLTPNIARAMGARTPRDELISSMLLGAMLLIITDSAAISLSLWLEETIPSGVAAAAIGAPALIWF 320
Cdd:PRK10577 249 SAAVVSAVGPIGFIGLAAPNLARLLGARRLRARLPLSPLIGALLLLLTDQLVRLLAGVGGELLPTGAVTALIGAPLLLWL 328

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 321 TRKKLTATDQLNLSMSQGKTALSKRA---VCSIALFSLVGILAYSFVTHGINGIQWSVP--GEFQWQLRWPRMLTALSVG 395
Cdd:PRK10577 329 LPRLRSAQSAPAMSAGDRVAARRRRVlawLLALGLLLLLALVVALSFGRDAHGWNWLSGqlLDALLPLRLPRLLAALLAG 408

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 396 IALSVAGIILQRIVYNPLASPDILGVSSGATFAIITTGVIAGSLLSAFNWGIAFFGSMSVLMLLLIIGKRSHFNPSNFVL 475
Cdd:PRK10577 409 AMLAVAGTLLQRLTRNPLASPEVLGISSGAGLGVVLALFLVPGAGFGWLLAAALLGALAALALILLLARRGGFAPERLLL 488

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 476 SGIALTALLEALVQFSLAQGSGDSYKILLWLTGSIYRVTAGTALMLCLAIIVLLTAVFAISRWLTLISIGRQFSNARGLN 555
Cdd:PRK10577 489 TGIALSALFTALIQLLLASGDPRAAQLLTWLSGSTYGVTWAQALPLLIVAVLLLALALLLRRWLDLLPLGDDTARALGLP 568

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 556 PTVANTLMLTIVALLCAFSTATVGPISFVGLVAPHMAMMLGARKVKEQLSVGALVGATLMLWADWLGQIAIYPSQVAAGT 635
Cdd:PRK10577 569 VTRARLALLLLAALLTAAATATVGPLSFVGLMAPHLARMLGGRRARPQLVLAALLGALLMVLADWLGRTLLFPYQIPAGL 648

                        650       660
                 ....*....|....*....|
gi 493793808 636 LVAILGSTYFLFLMLKSKFS 655
Cdd:PRK10577 649 LAALIGAPYFLWLLRRSRRR 668
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 381-653 2.44e-59

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 201.45  E-value: 2.44e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 381 WQLRWPRMLTALSVGIALSVAGIILQRIVYNPLASPDILGVSSGATFAIITTGVIAGSLLSAFNWGIAFFGSMSVLMLLL 460
Cdd:COG0609   32 WDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGAVLAIVLGGGLSALGLPLAAFLGALLAALLVY 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 461 IIGKR-SHFNPSNFVLSGIALTALLEALVQFSLAQGSGDSYK-ILLWLTGSIYRVTAGTALMLCLAIIVLLTAVFAISRW 538
Cdd:COG0609  112 LLARRgGGLSPLRLVLAGVAVSALFSALTSLLLLLADPEQLRsIVFWLMGSLAGASWDDVLLLLPVLLIGLLLALLLARA 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 539 LTLISIGRQFSNARGLNPTVANTLMLTIVALLCAFSTATVGPISFVGLVAPHMAMMLGARKVKEQLSVGALVGATLMLWA 618
Cdd:COG0609  192 LNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGLVVPHIARLLVGPDHRRLLPASALLGALLLLLA 271

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 493793808 619 DWLGQIAIYPSQVAAGTLVAILGSTYFLFLMLKSK 653
Cdd:COG0609  272 DTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 350-651 4.16e-55

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 190.05  E-value: 4.16e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808  350 IALFSLVGILAYSFVTHGINGIQWSVPGEFQWQLRWPRMLTALSVGIALSVAGIILQRIVYNPLASPDILGVSSGATFAI 429
Cdd:pfam01032   8 LSLFIGAVKISPSDVFSALLGGDDSLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGISSGAALGA 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808  430 ITTGVIAGSLLSAFNWGIAFFGSM-SVLMLLLIIGKRSHFNPSNFVLSGIALTALLEALVQFSLAQGSGDSYK-ILLWLT 507
Cdd:pfam01032  88 VLAILLGGSLSLFALPLAAFIGALlAALLVYFLSRGRGGASPLRLILAGIAVSALLSALTSLLLLLLNPEALQsILFWLM 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808  508 GSIYRVTAGTALMLCLAIIVLLTAVFAISRWLTLISIGRQFSNARGLNPTVANTLMLTIVALLCAFSTATVGPISFVGLV 587
Cdd:pfam01032 168 GSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVGPIGFVGLI 247

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 493793808  588 APHMAMMLGARKVKEQLSVGALVGATLMLWADWLGQIAIYPSQVAAGTLVAILGSTYFLFLMLK 651
Cdd:pfam01032 248 VPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 388-649 5.46e-37

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 138.84  E-value: 5.46e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 388 MLTALSVGIALSVAGIILQRIVYNPLASPDILGVSSGATFAIITTGVIAGSLLSAFNWGIAFFGSMSVLMLLLIIGKRSH 467
Cdd:cd06550    1 LLAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSNYALGAFAFAGALAIALLVLLLASRGG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 468 FNPSNFVLSGIALTALLEALVQFSLAQGSGDSYKILLWLTGSIYRVTAGTALMLCLAIIVLLTAVFAISRWLTLISIGRQ 547
Cdd:cd06550   81 LSPSKLILIGIVLSAFFSAGVILISLLSDDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFDED 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 548 FSNARGLNPTVANTLMLTIVALLCAFSTATVGPISFVGLVAPHMAMMLGARKVKEQLSVGALVGATLMLWADWLGQIaIY 627
Cdd:cd06550  161 LAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRT-LL 239

                        250       260
                 ....*....|....*....|..
gi 493793808 628 PSQVAAGTLVAILGSTYFLFLM 649
Cdd:cd06550  240 PSELPVGPVTALLGAPYFLYLL 261
 
Name Accession Description Interval E-value
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
1-655 0e+00

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 626.87  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808   1 MRTKHYIGYLALITLLSVFSLQIDTNLSLFEQWQLLTKPEvASEFRDVFFTQAQLPRLSITLLVGAMLGLTGSLMQQLTQ 80
Cdd:PRK10577  10 ARLPALLLALLLLLALALTLTQLSAALPLSQWLQALWGPD-ADDLEQLLLHYSRLPRLAIALLVGAALGLAGALLQQVLR 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808  81 NNLTSPLTLGTSSGAWLALVVVNIWFVDWVADYSALAAMAGALVAFGLIVSIAGVRNMTGLPLVVSGMVINILLGSIATA 160
Cdd:PRK10577  89 NPLASPTTLGVAAGAQLALVLATLFAPALLALASQLAAFAGGLLAAALVFALAGGKRLSPLRLVLAGMVVSLYLGALTTL 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 161 IIILNAQFAQNIFMWGAGDLSQYSWDWFEWLLPRCAIAIVILIVAPRILTLMKLGQEGAAARGLAVLPAFGTLMVMGIWL 240
Cdd:PRK10577 169 LLLFNEQYLQGLFLWGAGSLAQNDWSGVQRLLPRLLVGLLLLLLLARPLTLLGLGDDVARSLGLAVSLTRLAALALAVLL 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 241 VSASITAVGIISFIGLLTPNIARAMGARTPRDELISSMLLGAMLLIITDSAAISLSLWLEETIPSGVAAAAIGAPALIWF 320
Cdd:PRK10577 249 SAAVVSAVGPIGFIGLAAPNLARLLGARRLRARLPLSPLIGALLLLLTDQLVRLLAGVGGELLPTGAVTALIGAPLLLWL 328

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 321 TRKKLTATDQLNLSMSQGKTALSKRA---VCSIALFSLVGILAYSFVTHGINGIQWSVP--GEFQWQLRWPRMLTALSVG 395
Cdd:PRK10577 329 LPRLRSAQSAPAMSAGDRVAARRRRVlawLLALGLLLLLALVVALSFGRDAHGWNWLSGqlLDALLPLRLPRLLAALLAG 408

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 396 IALSVAGIILQRIVYNPLASPDILGVSSGATFAIITTGVIAGSLLSAFNWGIAFFGSMSVLMLLLIIGKRSHFNPSNFVL 475
Cdd:PRK10577 409 AMLAVAGTLLQRLTRNPLASPEVLGISSGAGLGVVLALFLVPGAGFGWLLAAALLGALAALALILLLARRGGFAPERLLL 488

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 476 SGIALTALLEALVQFSLAQGSGDSYKILLWLTGSIYRVTAGTALMLCLAIIVLLTAVFAISRWLTLISIGRQFSNARGLN 555
Cdd:PRK10577 489 TGIALSALFTALIQLLLASGDPRAAQLLTWLSGSTYGVTWAQALPLLIVAVLLLALALLLRRWLDLLPLGDDTARALGLP 568

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 556 PTVANTLMLTIVALLCAFSTATVGPISFVGLVAPHMAMMLGARKVKEQLSVGALVGATLMLWADWLGQIAIYPSQVAAGT 635
Cdd:PRK10577 569 VTRARLALLLLAALLTAAATATVGPLSFVGLMAPHLARMLGGRRARPQLVLAALLGALLMVLADWLGRTLLFPYQIPAGL 648

                        650       660
                 ....*....|....*....|
gi 493793808 636 LVAILGSTYFLFLMLKSKFS 655
Cdd:PRK10577 649 LAALIGAPYFLWLLRRSRRR 668
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 381-653 2.44e-59

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 201.45  E-value: 2.44e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 381 WQLRWPRMLTALSVGIALSVAGIILQRIVYNPLASPDILGVSSGATFAIITTGVIAGSLLSAFNWGIAFFGSMSVLMLLL 460
Cdd:COG0609   32 WDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGAVLAIVLGGGLSALGLPLAAFLGALLAALLVY 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 461 IIGKR-SHFNPSNFVLSGIALTALLEALVQFSLAQGSGDSYK-ILLWLTGSIYRVTAGTALMLCLAIIVLLTAVFAISRW 538
Cdd:COG0609  112 LLARRgGGLSPLRLVLAGVAVSALFSALTSLLLLLADPEQLRsIVFWLMGSLAGASWDDVLLLLPVLLIGLLLALLLARA 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 539 LTLISIGRQFSNARGLNPTVANTLMLTIVALLCAFSTATVGPISFVGLVAPHMAMMLGARKVKEQLSVGALVGATLMLWA 618
Cdd:COG0609  192 LNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGLVVPHIARLLVGPDHRRLLPASALLGALLLLLA 271

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 493793808 619 DWLGQIAIYPSQVAAGTLVAILGSTYFLFLMLKSK 653
Cdd:COG0609  272 DTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 350-651 4.16e-55

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 190.05  E-value: 4.16e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808  350 IALFSLVGILAYSFVTHGINGIQWSVPGEFQWQLRWPRMLTALSVGIALSVAGIILQRIVYNPLASPDILGVSSGATFAI 429
Cdd:pfam01032   8 LSLFIGAVKISPSDVFSALLGGDDSLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGISSGAALGA 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808  430 ITTGVIAGSLLSAFNWGIAFFGSM-SVLMLLLIIGKRSHFNPSNFVLSGIALTALLEALVQFSLAQGSGDSYK-ILLWLT 507
Cdd:pfam01032  88 VLAILLGGSLSLFALPLAAFIGALlAALLVYFLSRGRGGASPLRLILAGIAVSALLSALTSLLLLLLNPEALQsILFWLM 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808  508 GSIYRVTAGTALMLCLAIIVLLTAVFAISRWLTLISIGRQFSNARGLNPTVANTLMLTIVALLCAFSTATVGPISFVGLV 587
Cdd:pfam01032 168 GSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVGPIGFVGLI 247

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 493793808  588 APHMAMMLGARKVKEQLSVGALVGATLMLWADWLGQIAIYPSQVAAGTLVAILGSTYFLFLMLK 651
Cdd:pfam01032 248 VPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
FepG COG4779
ABC-type enterobactin transport system, permease component [Inorganic ion transport and ...
 381-652 2.56e-47

ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 443810  Cd Length: 344  Bit Score: 169.92  E-value: 2.56e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 381 WQLRWPRMLTALSVGIALSVAGIILQRIVYNPLASPDILGVSSGA-TFAIITTGVIAGSLLSAfnWGIAFFGSMSVLMLL 459
Cdd:COG4779   70 LELRLPRALAALLVGAALGLSGAIFQSLTRNPLASPDIIGITAGAsAGAVAAIVVLGGSGLAV--ALGALAGGLATALLV 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 460 LIIGKRSHFNPSNFVLSGIALTALLEALVQFSLAQGS-GDSYKILLWLTGSIYRVTAGTALMLCLAIIVLLTAVFAISRW 538
Cdd:COG4779  148 YLLAWRGGVSGYRLILVGIGVSAMLTAVNSYLLTRADlEDAQSAAVWLTGSLNGRTWEDVLPLAVALAVLLPLALALARR 227

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 539 LTLISIGRQFSNARGLNPTVANTLMLTIVALLCAFSTATVGPISFVGLVAPHMAMMLgARKVKEQLSVGALVGATLMLWA 618
Cdd:COG4779  228 LRLLELGDDTAAALGVRVERTRLLLLLVAVALAAVATAAAGPIAFVALAAPQIARRL-TRSPGPPLLPSALVGALLLLAA 306

                        250       260       270
                 ....*....|....*....|....*....|....
gi 493793808 619 DWLGQIAIYPSQVAAGTLVAILGSTYFLFLMLKS 652
Cdd:COG4779  307 DLVAQHLLAPVQLPVGVVTGALGGPYLLWLLIRE 340
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 25-292 3.46e-47

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 168.71  E-value: 3.46e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808  25 TNLSLFEQWQLLTKPEVASEFRDVFFtQAQLPRLSITLLVGAMLGLTGSLMQQLTQNNLTSPLTLGTSSGAWLALVVVNI 104
Cdd:COG0609    7 VPISLSDVLRALLGPDGDPTADLIVW-DLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGAVLAIV 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 105 WFVDWVADYSALAAMAGALVAFGLIVSIAGV-RNMTGLPLVVSGMVINILLGSIATAIIIL-NAQFAQNIFMWGAGDLSQ 182
Cdd:COG0609   86 LGGGLSALGLPLAAFLGALLAALLVYLLARRgGGLSPLRLVLAGVAVSALFSALTSLLLLLaDPEQLRSIVFWLMGSLAG 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 183 YSWDWFEWLLPRCAIAIVILIVAPRILTLMKLGQEGAAARGLAVLPAFGTLMVMGIWLVSASITAVGIISFIGLLTPNIA 262
Cdd:COG0609  166 ASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGLVVPHIA 245

                        250       260       270
                 ....*....|....*....|....*....|
gi 493793808 263 RAMGARTPRDELISSMLLGAMLLIITDSAA 292
Cdd:COG0609  246 RLLVGPDHRRLLPASALLGALLLLLADTLA 275
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 12-323 2.59e-46

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 166.16  E-value: 2.59e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808   12 LITLLSVFSLQI-DTNLSLFEQWQLLTKPevASEFRDVFFTQAQLPRLSITLLVGAMLGLTGSLMQQLTQNNLTSPLTLG 90
Cdd:pfam01032   1 LLLLLILLSLFIgAVKISPSDVFSALLGG--DDSLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808   91 TSSGAWLALVVVNIWFVDWVADYSALAAMAGALVAFGLIVSIAGVR-NMTGLPLVVSGMVINILLGSIATAIIIL-NAQF 168
Cdd:pfam01032  79 ISSGAALGAVLAILLGGSLSLFALPLAAFIGALLAALLVYFLSRGRgGASPLRLILAGIAVSALLSALTSLLLLLlNPEA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808  169 AQNIFMWGAGDLSQYSWDWFEWLLPRCAIAIVILIVAPRILTLMKLGQEGAAARGLAVLPAFGTLMVMGIWLVSASITAV 248
Cdd:pfam01032 159 LQSILFWLMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVV 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 493793808  249 GIISFIGLLTPNIARAMGARTPRDELISSMLLGAMLLIITDSAAISLSLWLEetIPSGVAAAAIGAPALIWFTRK 323
Cdd:pfam01032 239 GPIGFVGLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYE--LPVGIVTALIGAPFFIYLLLR 311
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 388-649 5.46e-37

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 138.84  E-value: 5.46e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 388 MLTALSVGIALSVAGIILQRIVYNPLASPDILGVSSGATFAIITTGVIAGSLLSAFNWGIAFFGSMSVLMLLLIIGKRSH 467
Cdd:cd06550    1 LLAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSNYALGAFAFAGALAIALLVLLLASRGG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 468 FNPSNFVLSGIALTALLEALVQFSLAQGSGDSYKILLWLTGSIYRVTAGTALMLCLAIIVLLTAVFAISRWLTLISIGRQ 547
Cdd:cd06550   81 LSPSKLILIGIVLSAFFSAGVILISLLSDDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFDED 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 548 FSNARGLNPTVANTLMLTIVALLCAFSTATVGPISFVGLVAPHMAMMLGARKVKEQLSVGALVGATLMLWADWLGQIaIY 627
Cdd:cd06550  161 LAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRT-LL 239

                        250       260
                 ....*....|....*....|..
gi 493793808 628 PSQVAAGTLVAILGSTYFLFLM 649
Cdd:cd06550  240 PSELPVGPVTALLGAPYFLYLL 261
fecD PRK09777
Fe(3+) dicitrate ABC transporter permease subunit FecD;
382-653 1.06e-33

Fe(3+) dicitrate ABC transporter permease subunit FecD;


Pssm-ID: 182071  Cd Length: 318  Bit Score: 131.32  E-value: 1.06e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 382 QLRWPRMLTALSVGIALSVAGIILQRIVYNPLASPDILGVSSGATFAIITTGVIAGSLlsAFNW--GIAFFGSMSVLMLL 459
Cdd:PRK09777  49 EYRLPRLLLALFVGAALAVSGVLVQGIVRNPLASPDILGVNHAASLASVGALLLFPSL--PVMWlpLLAFIGGMAGLILL 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 460 LIIGKRShfNPSNFVLSGIALTALLEALVQFSLAQGSGDSYKILLWLTGSIYRVTAGTALMLCLAIIVLLTAVFAISRWL 539
Cdd:PRK09777 127 KMLAGTH--QPMKLALTGVALSALWASLTDYLMLSRPQDINNALLWLTGSLWGRDWSFVKVALPWLILLLPLSLSFCRDL 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 540 TLISIGRQFSNARGLNPTVANTLMLTIVALLCAFSTATVGPISFVGLVAPHMAMMLGARKVKEQLSVGALVGATLMLWAD 619
Cdd:PRK09777 205 DLLALGDARATTLGVSVPHTQFWALLLAVALTATGVAACGPISFIGLVVPHLMRSLVGGRHRRLLPVSALTGALLLLLAD 284

                        250       260       270
                 ....*....|....*....|....*....|....
gi 493793808 620 WLGQIAIYPSQVAAGTLVAILGSTYFLFLMLKSK 653
Cdd:PRK09777 285 LLARIIHPPLELPAGVLTAIIGAPWFFWLLVRMR 318
fecC PRK11228
iron-dicitrate ABC transporter permease FecC;
382-648 1.08e-30

iron-dicitrate ABC transporter permease FecC;


Pssm-ID: 183042  Cd Length: 323  Bit Score: 122.88  E-value: 1.08e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 382 QLRWPRMLTALSVGIALSVAGIILQRIVYNPLASPDILGVSSGATFAIITTGVIAGSLLSAFNwgIAFF----GSMSVLM 457
Cdd:PRK11228  49 NLRLPRSLVAVLIGASLALAGALLQTLTHNPLASPSLLGINSGAALAMALTSALSPTPFAGYS--LAFIaacgGGLSWLL 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 458 LLLIIGKRSHFNPSN-FVLSGIALTALLEALVQFSLAQGSGDSYKILLWLTGSIYRVTAGTALMLCLAIIVLLTAVFAIS 536
Cdd:PRK11228 127 VMTAGGGWRHTHDRNrLILAGIALSALCMALTRITLLLAEDHAYGIFYWLAGGVSHARWQEVWQLLPFVVTAVPVVLLLA 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 537 RWLTLISIGRQFSNARGLNPTVANTLMLTIVALLCAFSTATVGPISFVGLVAPHMAMMLGARKVKEQLSVGALVGATLML 616
Cdd:PRK11228 207 NQLNLLNLSDSSAHTLGVNLTRLRLVVNMLVLLLVGACVSVAGPVAFIGLLVPHLARFWIGYDQRNVLPMSMLLGATLML 286

                        250       260       270
                 ....*....|....*....|....*....|..
gi 493793808 617 WADWLGQIAIYPSQVAAGTLVAILGSTYFLFL 648
Cdd:PRK11228 287 LADLLARALAFPGELPAGAVLALIGAPCFVWL 318
BtuC COG4139
ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and ...
 379-653 1.58e-29

ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and metabolism];


Pssm-ID: 443314  Cd Length: 327  Bit Score: 119.57  E-value: 1.58e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 379 FQWQLRWPRMLTALSVGIALSVAGIILQRIVYNPLASPDILGVSSGATFAIITTGVIAGSLLSafNWGI---AFFGSMSV 455
Cdd:COG4139   50 FVWQLRLPRTLAAVLVGASLAVSGAVMQALFENPLAEPGLLGISNGAGVGLVLVVLLGGGLLP--PWLLslaAIAGALLV 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 456 LMLLLIIGKRsHFNPSNFVLSGIAL----TALLEALVQFSLAQgsgDSYKILLWLTGSIYRVTAGTALMLCLAIIVLLTA 531
Cdd:COG4139  128 TLLLLAFARR-RLSNARLLLIGVALgiicSAIMTWAVYFSSSL---DLRQLMYWMMGSFGGVDWRQLWLLLALLPVLLWL 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 532 VFAISRwLTLISIGRQFSNARGLNPTVANTLMLTIVALLCAFSTATVGPISFVGLVAPHMAMMLGARKVKEQLSVGALVG 611
Cdd:COG4139  204 CLQGKP-LNLLLLGENQARQLGLSVHRWRNLLVLATGLLVGVSVALAGPIGFVGLVVPHLLRLLGTTDHRFLLPACALAG 282

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 493793808 612 ATLMLWADWLGQIAIYPSQVAAGTLVAILGSTYFLFLMLKSK 653
Cdd:COG4139  283 AALLLLADIIARLALSSAELPIGVVTATLGAPVFIWLLLRRR 324
PRK03784 PRK03784
vtamin B12-transporter permease; Provisional
 352-653 2.03e-28

vtamin B12-transporter permease; Provisional


Pssm-ID: 235159  Cd Length: 331  Bit Score: 116.59  E-value: 2.03e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 352 LFSLVGILAYSFVTHGINGIQWSVPGE--------FQWQLRWPRMLTALSVGIALSVAGIILQRIVYNPLASPDILGVSS 423
Cdd:PRK03784  18 LLGLSVLLLLALLLSLCAGEQWISPGDwlsprgelFVWQLRLPRTLAVLLVGAALAVSGAVMQALFENPLAEPGLLGVSN 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 424 GATFAIITTGVIAGSLLSAFNWGI-AFFGSMSVLMLLLIIGKRSHFNPSNFVLSGIAL----TALLEALVQFSlaqGSGD 498
Cdd:PRK03784  98 GAGVALVAAVLLGQGLLPPWALSLcAIAGALLITLILLRFARRHRLSTSRLLLAGVALgiicSALMTWAVYFS---TSLD 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 499 SYKILLWLTGSIYRVTAGTAlMLCLAIIVLLTAVFAISRWLTLISIGRQFSNARGLNPTVANTLMLTIVALLCAFSTATV 578
Cdd:PRK03784 175 LRQLMYWMMGGFGGVDWRQS-WLMLALLPVLIWLCCQGRPLNMLALGEISARQLGLPLWFWRNLLVLATGWLVGVSVALA 253

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 493793808 579 GPISFVGLVAPHMAMMLGARKVKEQLSVGALVGATLMLWADWLGQIAIYPSQVAAGTLVAILGSTYFLFLMLKSK 653
Cdd:PRK03784 254 GAIGFIGLVIPHILRLCGLTDHRVLLPGCALAGASLLLLADIVARLALASAELPIGVVTATLGAPVFIWLLLRSH 328
fecC PRK11228
iron-dicitrate ABC transporter permease FecC;
52-325 1.38e-26

iron-dicitrate ABC transporter permease FecC;


Pssm-ID: 183042  Cd Length: 323  Bit Score: 110.94  E-value: 1.38e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808  52 QAQLPRLSITLLVGAMLGLTGSLMQQLTQNNLTSPLTLGTSSGAWLALVVVNIWFVDWVADYS-ALAAMAGALVAFGLIV 130
Cdd:PRK11228  49 NLRLPRSLVAVLIGASLALAGALLQTLTHNPLASPSLLGINSGAALAMALTSALSPTPFAGYSlAFIAACGGGLSWLLVM 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 131 SIAGVRNMTGL--PLVVSGMVINILLGSIATAIIILNAQFAQNIFMWGAGDLSQYSWDWFEWLLPRCAIAIVILIVAPRI 208
Cdd:PRK11228 129 TAGGGWRHTHDrnRLILAGIALSALCMALTRITLLLAEDHAYGIFYWLAGGVSHARWQEVWQLLPFVVTAVPVVLLLANQ 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 209 LTLMKLGQEGAAARGLAVLPAFGTLMVMGIWLVSASITAVGIISFIGLLTPNIARAMGARTPRDELISSMLLGAMLLIIT 288
Cdd:PRK11228 209 LNLLNLSDSSAHTLGVNLTRLRLVVNMLVLLLVGACVSVAGPVAFIGLLVPHLARFWIGYDQRNVLPMSMLLGATLMLLA 288

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 493793808 289 DSAAISLSLWLEetIPSGVAAAAIGAPALIWFTRKKL 325
Cdd:PRK11228 289 DLLARALAFPGE--LPAGAVLALIGAPCFVWLARRRG 323
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 58-295 3.37e-25

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 105.33  E-value: 3.37e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808  58 LSITLLVGAMLGLTGSLMQQLTQNNLTSPLTLGTSSGAWLALVVVNIWFVDWVADYSALAAMAGALVAFGLIVSIAGVRN 137
Cdd:cd06550    1 LLAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSNYALGAFAFAGALAIALLVLLLASRGG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 138 MTGLPLVVSGMVINILLGSIATAIIILNAQFAQNIFMWGAGDLSQYSWDWFEWLLPRCAIAIVILIVAPRILTLMKLGQE 217
Cdd:cd06550   81 LSPSKLILIGIVLSAFFSAGVILISLLSDDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFDED 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 493793808 218 GAAARGLAVLPAFGTLMVMGIWLVSASITAVGIISFIGLLTPNIARAMGARTPRDELISSMLLGAMLLIITDSAAISL 295
Cdd:cd06550  161 LAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRTL 238
PRK10441 PRK10441
Fe(3+)-siderophore ABC transporter permease;
384-648 1.18e-23

Fe(3+)-siderophore ABC transporter permease;


Pssm-ID: 182464  Cd Length: 335  Bit Score: 102.48  E-value: 1.18e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 384 RWPRMLTALSVGIALSVAGIILQRIVYNPLASPDILGVSSGATFAIITTGVIAGSLLSAFNWGIAFFGSMSVLMLLLIIG 463
Cdd:PRK10441  60 RLPRTLAGLLAGGALGLAGALMQTLTRNPLADPGLLGVNAGASFAIVLGAALFGYSSAQEQLAMAFAGALVASLIVAFTG 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 464 KR--SHFNPSNFVLSGIALTALLEALVQfSLAQGSGDSYKIL-LWLTGSIYRVTAGTALMLCLAIIVLLTAVFAISRWLT 540
Cdd:PRK10441 140 SQggGQLSPVRLTLAGVALAAVLEGLTS-GIALLNPDVYDQLrFWQAGSLDIRNLHTLKVVLIPVLIAGATALLLSRALN 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 541 LISIGRQFSNARGLNPTVANTLMLTIVALLCAFSTATVGPISFVGLVAPHMAMMLGARKVKEQLSVGALVGATLMLWADW 620
Cdd:PRK10441 219 SLSLGSDTATALGSRVARTQLIGLLAITVLCGSATAVVGPIAFIGLMMPHMARWLVGADHRWSLPVTLLATPALLLFADI 298

                        250       260
                 ....*....|....*....|....*...
gi 493793808 621 LGQIaIYPSQVAAGTLVAILGSTYFLFL 648
Cdd:PRK10441 299 IGRL-LVPGELRVSVVSAFIGAPVLIFL 325
PRK10440 PRK10440
iron-enterobactin ABC transporter permease;
382-651 1.40e-22

iron-enterobactin ABC transporter permease;


Pssm-ID: 182463  Cd Length: 330  Bit Score: 99.40  E-value: 1.40e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 382 QLRWPRMLTALSVGIALSVAGIILQRIVYNPLASPDILGVSSGATFAIITTGVIAGSLLSAFNWGiAFFGSMSVLMLLLI 461
Cdd:PRK10440  57 EWRLPRVLMALLIGAALGVSGAIFQSLMRNPLGSPDVMGFNTGAWSGVLVAMVLFGQDLTAIALA-AMAGGIVTSLLVWL 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 462 IGKRSHFNPSNFVLSGIALTALLEALVQFSLAQGSGDS-YKILLWLTGSIYRVTAGTALMLCLAIIVLLTAVFAISRWLT 540
Cdd:PRK10440 136 LAWRNGIDTFRLIIIGIGVRAMLVAFNTWLLLKASLETaLTAGLWNAGSLNGLTWAKTSPSAPIIILMLIAAALLVRRMR 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 541 LISIGRQFSNARGLNPTVANTLMLTIVALLCAFSTATVGPISFVGLVAPHMAMML-GARKVKeqLSVGALVGATLMLWAD 619
Cdd:PRK10440 216 LLEMGDDTACALGVSVERSRLLLMLVAVVLTAAATALAGPISFIALVAPHIARRLsGTARWG--LTQAALCGALLLLAAD 293

                        250       260       270
                 ....*....|....*....|....*....|..
gi 493793808 620 WLGQIAIYPSQVAAGTLVAILGSTYFLFLMLK 651
Cdd:PRK10440 294 LCAQQLFMPYQLPVGVVTVSLGGIYLIVLLIQ 325
PRK10440 PRK10440
iron-enterobactin ABC transporter permease;
51-319 3.20e-22

iron-enterobactin ABC transporter permease;


Pssm-ID: 182463  Cd Length: 330  Bit Score: 98.24  E-value: 3.20e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808  51 TQAQLPRLSITLLVGAMLGLTGSLMQQLTQNNLTSPLTLGTSSGAWLALVVVNIWFVDWVADYsALAAMAGALVAFGLIV 130
Cdd:PRK10440  56 TEWRLPRVLMALLIGAALGVSGAIFQSLMRNPLGSPDVMGFNTGAWSGVLVAMVLFGQDLTAI-ALAAMAGGIVTSLLVW 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 131 SIAGVRNMTGLPLVVSGMVINILLGSIATAIII-LNAQFAQNIFMWGAGDLSQYSWDWFEWLLPRCAIAIVILIVAPRIL 209
Cdd:PRK10440 135 LLAWRNGIDTFRLIIIGIGVRAMLVAFNTWLLLkASLETALTAGLWNAGSLNGLTWAKTSPSAPIIILMLIAAALLVRRM 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 210 TLMKLGQEGAAARGLAVLPAFGTLMVMGIWLVSASITAVGIISFIGLLTPNIARAMgARTPRDELISSMLLGAMLLIITD 289
Cdd:PRK10440 215 RLLEMGDDTACALGVSVERSRLLLMLVAVVLTAAATALAGPISFIALVAPHIARRL-SGTARWGLTQAALCGALLLLAAD 293

                        250       260       270
                 ....*....|....*....|....*....|
gi 493793808 290 SAAisLSLWLEETIPSGVAAAAIGAPALIW 319
Cdd:PRK10440 294 LCA--QQLFMPYQLPVGVVTVSLGGIYLIV 321
btuC PRK09535
cobalamin ABC transporter permease BtuC;
382-651 3.34e-22

cobalamin ABC transporter permease BtuC;


Pssm-ID: 236553  Cd Length: 366  Bit Score: 98.67  E-value: 3.34e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 382 QLRWPRMLTALSVGIALSVAGIILQRIVYNPLASPDILGVSSGATFAIITTGVIAGSLLSAFNwGIAFFGSMSVLMLLLI 461
Cdd:PRK09535  93 QIRLPRILLAATVGFALAAAGTVMQGFFRNPMADPSIIGVSSGAAVGAVAAIVLPLAVPFGLQ-AAAFAGALVAAFGVYA 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 462 IGKRSHFNP-SNFVLSGIALTALLEALVQFSLAQGSGDSYKILLWLTGSIYRVTAGTALMLCLAIIVLLTAVFAISRWLT 540
Cdd:PRK09535 172 IATENGRTPvATLLLAGVAVQTFLGAVISYLLLHSGESLRRAVYWLMGHLHGSTWSDVEVALPVVVVGFVVLLAYARDLN 251

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 541 LISIGRQFSNARGLNPTVANTLMLTIVALLCAFSTATVGPISFVGLVAPHMAMMLGARKVKEQLSVGALVGATLMLWADW 620
Cdd:PRK09535 252 VLLLGEEDAHTLGIEVERTKRLLLALASVVTAAAVAVAGVIGFVGLIVPHVMRLLVGPDHRILLPTSALAGASFLVATDT 331

                        250       260       270
                 ....*....|....*....|....*....|.
gi 493793808 621 LGQIAiyPSQVAAGTLVAILGSTYFLFLMLK 651
Cdd:PRK09535 332 VARSG--PAEVPVGIVTAALGAPFFLYLLRT 360
PRK10441 PRK10441
Fe(3+)-siderophore ABC transporter permease;
51-289 5.30e-20

Fe(3+)-siderophore ABC transporter permease;


Pssm-ID: 182464  Cd Length: 335  Bit Score: 91.69  E-value: 5.30e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808  51 TQAQLPRLSITLLVGAMLGLTGSLMQQLTQNNLTSPLTLGTSSGAWLALVV-VNIWFVDWVADYSALAAmAGALVAfGLI 129
Cdd:PRK10441  57 LDARLPRTLAGLLAGGALGLAGALMQTLTRNPLADPGLLGVNAGASFAIVLgAALFGYSSAQEQLAMAF-AGALVA-SLI 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 130 VSIAGVR---NMTGLPLVVSGMVINILLGSIATAIIILNAQFAQNIFMWGAGDLSQYSWDWFEWLLPRCAIAIVILIVAP 206
Cdd:PRK10441 135 VAFTGSQgggQLSPVRLTLAGVALAAVLEGLTSGIALLNPDVYDQLRFWQAGSLDIRNLHTLKVVLIPVLIAGATALLLS 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 207 RILTLMKLGQEGAAARGLAVLPAFGTLMVMGIWLVSASITAVGIISFIGLLTPNIARAMGARTPRDELISSMLLGAMLLI 286
Cdd:PRK10441 215 RALNSLSLGSDTATALGSRVARTQLIGLLAITVLCGSATAVVGPIAFIGLMMPHMARWLVGADHRWSLPVTLLATPALLL 294


                 ...
gi 493793808 287 ITD 289
Cdd:PRK10441 295 FAD 297
fecD PRK09777
Fe(3+) dicitrate ABC transporter permease subunit FecD;
1-307 7.64e-20

Fe(3+) dicitrate ABC transporter permease subunit FecD;


Pssm-ID: 182071  Cd Length: 318  Bit Score: 90.88  E-value: 7.64e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808   1 MRTKHYIGYLALITLLSVFSLQIDTNLSLFEQWQLLTKPEVASEFrdvFFTQAQLPRLSITLLVGAMLGLTGSLMQQLTQ 80
Cdd:PRK09777   1 MKIALVIFITLALAGCALLSLRMGVIPLPWRALLTDWQAGDEHYY---VLMEYRLPRLLLALFVGAALAVSGVLVQGIVR 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808  81 NNLTSPLTLGTSSGAWLALVVVNIWFVDWVADYSALAAMAGALVAFGLIVSIAGVRnmTGLPLVVSGMVINILLGSIATA 160
Cdd:PRK09777  78 NPLASPDILGVNHAASLASVGALLLFPSLPVMWLPLLAFIGGMAGLILLKMLAGTH--QPMKLALTGVALSALWASLTDY 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 161 IIILNAQFAQNIFMWGAGDLSQYSWDWFEWLLPRCAIAIVILIVAPRILTLMKLGQEGAAARGLAVLPAFGTLMVMGIWL 240
Cdd:PRK09777 156 LMLSRPQDINNALLWLTGSLWGRDWSFVKVALPWLILLLPLSLSFCRDLDLLALGDARATTLGVSVPHTQFWALLLAVAL 235

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 493793808 241 VSASITAVGIISFIGLLTPNIARAMGARTPRDELISSMLLGAMLLIITDSAAISLSLWLEetIPSGV 307
Cdd:PRK09777 236 TATGVAACGPISFIGLVVPHLMRSLVGGRHRRLLPVSALTGALLLLLADLLARIIHPPLE--LPAGV 300
PRK03784 PRK03784
vtamin B12-transporter permease; Provisional
 9-289 8.46e-19

vtamin B12-transporter permease; Provisional


Pssm-ID: 235159  Cd Length: 331  Bit Score: 88.09  E-value: 8.46e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808   9 YLALITLLSVFSLQIdtNLSLFEQWQLLTKPevASEFRDVFFTQAQLPRLSITLLVGAMLGLTGSLMQQLTQNNLTSPLT 88
Cdd:PRK03784  17 WLLGLSVLLLLALLL--SLCAGEQWISPGDW--LSPRGELFVWQLRLPRTLAVLLVGAALAVSGAVMQALFENPLAEPGL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808  89 LGTSSGAWLALVVVNIWFVDWVADYS-ALAAMAGALVAFGLIVSIAGVRNMTGLPLVVSGMVINILLGSIATAIIILNAQ 167
Cdd:PRK03784  93 LGVSNGAGVALVAAVLLGQGLLPPWAlSLCAIAGALLITLILLRFARRHRLSTSRLLLAGVALGIICSALMTWAVYFSTS 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 168 FAQNIFM-WGAGDLSQYSW--DWFEWLLPrcaIAIVILIVAPRILTLMKLGQEGAAARGLAVLPAFGTLMVMGIWLVSAS 244
Cdd:PRK03784 173 LDLRQLMyWMMGGFGGVDWrqSWLMLALL---PVLIWLCCQGRPLNMLALGEISARQLGLPLWFWRNLLVLATGWLVGVS 249

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 493793808 245 ITAVGIISFIGLLTPNIARAMGARTPRDELISSMLLGAMLLIITD 289
Cdd:PRK03784 250 VALAGAIGFIGLVIPHILRLCGLTDHRVLLPGCALAGASLLLLAD 294
btuC PRK09535
cobalamin ABC transporter permease BtuC;
51-294 6.20e-16

cobalamin ABC transporter permease BtuC;


Pssm-ID: 236553  Cd Length: 366  Bit Score: 79.79  E-value: 6.20e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808  51 TQAQLPRLSITLLVGAMLGLTGSLMQQLTQNNLTSPLTLGTSSGAWLAlVVVNIWFVDWVADYSALAAMAGALVAFGLIV 130
Cdd:PRK09535  92 LQIRLPRILLAATVGFALAAAGTVMQGFFRNPMADPSIIGVSSGAAVG-AVAAIVLPLAVPFGLQAAAFAGALVAAFGVY 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 131 SIAGVRNMTGLP-LVVSGMVINILLGSIATAIIILNAQFAQNIFMWGAGDLSQYSWDWFEWLLPRCAIAIVILIVAPRIL 209
Cdd:PRK09535 171 AIATENGRTPVAtLLLAGVAVQTFLGAVISYLLLHSGESLRRAVYWLMGHLHGSTWSDVEVALPVVVVGFVVLLAYARDL 250

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 210 TLMKLGQEGAAARGLAVLPAFGTLMVMGIWLVSASITAVGIISFIGLLTPNIARAMGARTPRDELISSMLLGAMLLIITD 289
Cdd:PRK09535 251 NVLLLGEEDAHTLGIEVERTKRLLLALASVVTAAAVAVAGVIGFVGLIVPHVMRLLVGPDHRILLPTSALAGASFLVATD 330


                 ....*
gi 493793808 290 SAAIS 294
Cdd:PRK09535 331 TVARS 335
ZnuB COG1108
ABC-type Mn2+/Zn2+ transport system, permease component [Inorganic ion transport and ...
 432-653 5.21e-04

ABC-type Mn2+/Zn2+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440725  Cd Length: 260  Bit Score: 42.34  E-value: 5.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 432 TGVIAGSLLSAFNWGIAFFGSMSVLMLLLIIGKRSHFNPSN----FVLSGIALTALLEALVQFSlaQGSGDSYkillwLT 507
Cdd:COG1108   43 PGVALAFLLGLSPLLGALVAGLLAALLIGLLRRRSRLKEDTaigiVFSGGFALGVLLISLVPGS--AVDLMSY-----LF 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493793808 508 GSIYRVTAGTALMLCLAIIVLLTAVFAISRWLTLISIGRQFSNARGLNPTVANTLMLTIVALLCAFSTATVGPISFVGL- 586
Cdd:COG1108  116 GSILAVSRSDLLLLAVLAAVVLLLLLLFYRELLLVSFDPELARASGLPVRLLHLLLLVLLALTVVAALQAVGALLVSALl 195

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 493793808 587 VAPHMAMMLGARKVKEQLSVGALVGATLMLWADWLgqiAIYPSQVAAGTLVAILGSTYFLFLMLKSK 653
Cdd:COG1108  196 IIPAATARLLTRSLRRMLLLAVLIGVLSSVLGLYL---SYYLDLPTGPTIVLVAGLLFLLSLLFSPR 259
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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