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Conserved domains on  [gi|493291867|ref|WP_006249558|]
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valine--tRNA ligase [Mannheimia haemolytica]

Protein Classification

valine--tRNA ligase( domain architecture ID 11424975)

valine--tRNA ligase catalyzes the attachment of valine to tRNA(Val)

CATH:  1.10.730.10|3.90.740.10
Gene Ontology:  GO:0006438|GO:0005524|GO:0004832|GO:0002161
SCOP:  4000856

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
ValS COG0525
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ...
 7-952 0e+00

Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


:

Pssm-ID: 440291 [Multi-domain]  Cd Length: 877  Bit Score: 1657.10  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867   7 MEDRFNPSAVEQALYQHWESQGYFKPSEDINAPSYCIAIPPPNVTGSLHMGHAFQQTLMDTLIRFNRMEGNNTLWQTGTD 86
Cdd:COG0525    3 LPKTYDPKEVEAKWYQYWEENGYFKADPDSDKEPFTIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLWQPGTD 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  87 HAGIATQMVVERKIAaEEGKTRHDYGREAFINKIWDWKAYSGGTISQQMRRLGNSIDWDRERFTMDEGLSNAVKEVFVRL 166
Cdd:COG0525   83 HAGIATQAVVERQLA-EEGKSRHDLGREKFLERVWEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKAVREVFVRL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 167 HEEGLIYRGKRLVNWDPKLHTAISDLEVENKESKGSLWHFRYPLAngaktaDGLDYLVVATTRPETMLGDTAVAVHPEDE 246
Cdd:COG0525  162 YEKGLIYRGKRLVNWDPKLKTALSDLEVEHEEVKGHLWHIRYPLA------DGSGYIVVATTRPETMLGDTAVAVHPEDE 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 247 RYQALIGKSVILPLANREIPIIADEYVDREFGTGVVKITPAHDFNDYEVGKRHGLPMVNVMTLNADIRAEAEIigtdgkp 326
Cdd:COG0525  236 RYKHLIGKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINILDEDGTINENAGK------- 308

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 327 lsdytapipadYQGLERFAARKKIVADFEALGLLDQIKPHDLKVPYGDRGGVPIEPMLTDQWYVSVKPLAEVATKAVEDG 406
Cdd:COG0525  309 -----------YRGLDRFEARKAIVADLEELGLLVKVEPHKHSVGHSDRSGTVIEPYLSDQWFVKMKPLAKPAIEAVEDG 377

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 407 EIQFVPKQYENLYFSWMRDIQDWCISRQLWWGHRIPAWYDEQGNVYVARDEAEVRAKHnlpADLPLKQDEDVLDTWFSSG 486
Cdd:COG0525  378 EIKFVPERWEKTYFHWMENIRDWCISRQLWWGHRIPAWYCPDGEVYVARTEPEACAKA---GSVNLTQDEDVLDTWFSSA 454

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 487 LWTFSTLGWPEQTKELKMFHPTDVLITGFDIIFFWVARMIMFTMHFIKdengkpQVPFKTVYVTGLIRDEQGQKMSKSKG 566
Cdd:COG0525  455 LWPFSTLGWPEKTEDLKYFYPTSVLVTGFDIIFFWVARMIMMGLHFTG------EVPFKDVYIHGLVRDEQGRKMSKSKG 528

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 567 NVLDPIDMIDgislddllekrtgnmmqpqlaekiakatrkefaegivAHGTDALRFTLTALASNGRDINWDMKRLEGYRN 646
Cdd:COG0525  529 NVIDPLDLID-------------------------------------KYGADALRFTLAALASPGRDIKFDEERVEGYRN 571

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 647 FCNKLWNASRYVLTN---DKLDLSEGDVEFSLADRWIESQFNRTVETFRTALSQYRFDLVANAIYEFTWDQFCDWYLELT 723
Cdd:COG0525  572 FANKLWNASRFVLMNlegFDPGLDPDPEELSLADRWILSRLNKTIAEVTEALEKYRFDEAAQALYDFVWNEFCDWYLELA 651

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 724 KPIFFKGTDVQRRGASRTLVNVLEKLLRLIHPVMPFITEEIWQKVKGfvGIEADTIMLQKFPQFDPLAIDETAESQINFI 803
Cdd:COG0525  652 KPRLYGGDEAAKRETRATLVYVLEQILRLLHPFMPFITEEIWQKLPP--RKEGESIMLAPWPEADEELIDEEAEAEFEWL 729

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 804 KEVIVAVRNIRAESNIAPSKGLDLIARNFSADEVSILNANEVLLKSMAKLDSVKVLENgENAPLSVAKLVANGEILIPMA 883
Cdd:COG0525  730 KEVISAIRNIRAEMNIPPSKKLPLLLKGADEADRARLEENAAYIKRLARLEEITILVD-EKPEGAASAVVGGAEVFLPLE 808

                        890       900       910       920       930       940
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 493291867 884 GFINKEAELARLTKEMDKLKGEVARIEGKLSNEAFVAKAPEQVIAKEREKMQEYLSGLEKLQVQYQEIE 952
Cdd:COG0525  809 GLIDVEAERARLEKELAKLEKEIARVEKKLSNEGFVAKAPAEVVEKEREKLAEAEAKLEKLEEQLARLK 877
L-asparaginase_like super family cl00216
Bacterial L-asparaginases and related enzymes; Asparaginases (amidohydrolases, E.C. 3.5.1.1) ...
 592-628 3.26e-04

Bacterial L-asparaginases and related enzymes; Asparaginases (amidohydrolases, E.C. 3.5.1.1) are dimeric or tetrameric enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases, one highly specific for asparagine and localized to the periplasm (type II L-asparaginase), and a second (asparaginase- glutaminase) present in the cytosol (type I L-asparaginase) that hydrolyzes both asparagine and glutamine with similar specificities and has a lower affinity for its substrate. Bacterial L-asparaginases (type II) are potent antileukemic agents and have been used in the treatment of acute lymphoblastic leukemia (ALL). A conserved threonine residue is thought to supply the nucleophile hydroxy-group that attacks the amide bond. Many bacterial L-asparaginases have both L-asparagine and L-glutamine hydrolysis activities, to a different degree, and some of them are annotated as asparaginase/glutaminase. This wider family also includes a subunit of an archaeal Glu-tRNA amidotransferase.


The actual alignment was detected with superfamily member cd08962:

Pssm-ID: 469665 [Multi-domain]  Cd Length: 402  Bit Score: 44.15  E-value: 3.26e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 493291867 592 MQPQLAEKIAKATRKEFAEG----IVAHGTDALRFTLTALA 628
Cdd:cd08962  128 MTPEYWVKIAEAVYKEIKEGadgvVVAHGTDTMHYTASALS 168
 
Name Accession Description Interval E-value
ValS COG0525
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ...
 7-952 0e+00

Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 440291 [Multi-domain]  Cd Length: 877  Bit Score: 1657.10  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867   7 MEDRFNPSAVEQALYQHWESQGYFKPSEDINAPSYCIAIPPPNVTGSLHMGHAFQQTLMDTLIRFNRMEGNNTLWQTGTD 86
Cdd:COG0525    3 LPKTYDPKEVEAKWYQYWEENGYFKADPDSDKEPFTIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLWQPGTD 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  87 HAGIATQMVVERKIAaEEGKTRHDYGREAFINKIWDWKAYSGGTISQQMRRLGNSIDWDRERFTMDEGLSNAVKEVFVRL 166
Cdd:COG0525   83 HAGIATQAVVERQLA-EEGKSRHDLGREKFLERVWEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKAVREVFVRL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 167 HEEGLIYRGKRLVNWDPKLHTAISDLEVENKESKGSLWHFRYPLAngaktaDGLDYLVVATTRPETMLGDTAVAVHPEDE 246
Cdd:COG0525  162 YEKGLIYRGKRLVNWDPKLKTALSDLEVEHEEVKGHLWHIRYPLA------DGSGYIVVATTRPETMLGDTAVAVHPEDE 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 247 RYQALIGKSVILPLANREIPIIADEYVDREFGTGVVKITPAHDFNDYEVGKRHGLPMVNVMTLNADIRAEAEIigtdgkp 326
Cdd:COG0525  236 RYKHLIGKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINILDEDGTINENAGK------- 308

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 327 lsdytapipadYQGLERFAARKKIVADFEALGLLDQIKPHDLKVPYGDRGGVPIEPMLTDQWYVSVKPLAEVATKAVEDG 406
Cdd:COG0525  309 -----------YRGLDRFEARKAIVADLEELGLLVKVEPHKHSVGHSDRSGTVIEPYLSDQWFVKMKPLAKPAIEAVEDG 377

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 407 EIQFVPKQYENLYFSWMRDIQDWCISRQLWWGHRIPAWYDEQGNVYVARDEAEVRAKHnlpADLPLKQDEDVLDTWFSSG 486
Cdd:COG0525  378 EIKFVPERWEKTYFHWMENIRDWCISRQLWWGHRIPAWYCPDGEVYVARTEPEACAKA---GSVNLTQDEDVLDTWFSSA 454

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 487 LWTFSTLGWPEQTKELKMFHPTDVLITGFDIIFFWVARMIMFTMHFIKdengkpQVPFKTVYVTGLIRDEQGQKMSKSKG 566
Cdd:COG0525  455 LWPFSTLGWPEKTEDLKYFYPTSVLVTGFDIIFFWVARMIMMGLHFTG------EVPFKDVYIHGLVRDEQGRKMSKSKG 528

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 567 NVLDPIDMIDgislddllekrtgnmmqpqlaekiakatrkefaegivAHGTDALRFTLTALASNGRDINWDMKRLEGYRN 646
Cdd:COG0525  529 NVIDPLDLID-------------------------------------KYGADALRFTLAALASPGRDIKFDEERVEGYRN 571

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 647 FCNKLWNASRYVLTN---DKLDLSEGDVEFSLADRWIESQFNRTVETFRTALSQYRFDLVANAIYEFTWDQFCDWYLELT 723
Cdd:COG0525  572 FANKLWNASRFVLMNlegFDPGLDPDPEELSLADRWILSRLNKTIAEVTEALEKYRFDEAAQALYDFVWNEFCDWYLELA 651

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 724 KPIFFKGTDVQRRGASRTLVNVLEKLLRLIHPVMPFITEEIWQKVKGfvGIEADTIMLQKFPQFDPLAIDETAESQINFI 803
Cdd:COG0525  652 KPRLYGGDEAAKRETRATLVYVLEQILRLLHPFMPFITEEIWQKLPP--RKEGESIMLAPWPEADEELIDEEAEAEFEWL 729

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 804 KEVIVAVRNIRAESNIAPSKGLDLIARNFSADEVSILNANEVLLKSMAKLDSVKVLENgENAPLSVAKLVANGEILIPMA 883
Cdd:COG0525  730 KEVISAIRNIRAEMNIPPSKKLPLLLKGADEADRARLEENAAYIKRLARLEEITILVD-EKPEGAASAVVGGAEVFLPLE 808

                        890       900       910       920       930       940
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 493291867 884 GFINKEAELARLTKEMDKLKGEVARIEGKLSNEAFVAKAPEQVIAKEREKMQEYLSGLEKLQVQYQEIE 952
Cdd:COG0525  809 GLIDVEAERARLEKELAKLEKEIARVEKKLSNEGFVAKAPAEVVEKEREKLAEAEAKLEKLEEQLARLK 877
valS PRK05729
valyl-tRNA synthetase; Reviewed
 5-953 0e+00

valyl-tRNA synthetase; Reviewed


Pssm-ID: 235582 [Multi-domain]  Cd Length: 874  Bit Score: 1608.24  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867   5 FTMEDRFNPSAVEQALYQHWESQGYFKPSEDiNAPSYCIAIPPPNVTGSLHMGHAFQQTLMDTLIRFNRMEGNNTLWQTG 84
Cdd:PRK05729   3 MELPKTYDPKEVEAKWYQKWEEKGYFKPDDN-SKKPFSIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLWLPG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  85 TDHAGIATQMVVERKIAAEeGKTRHDYGREAFINKIWDWKAYSGGTISQQMRRLGNSIDWDRERFTMDEGLSNAVKEVFV 164
Cdd:PRK05729  82 TDHAGIATQMVVERQLAAE-GKSRHDLGREKFLEKVWEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKAVREVFV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 165 RLHEEGLIYRGKRLVNWDPKLHTAISDLEVENKESKGSLWHFRYPLAngaktaDGLDYLVVATTRPETMLGDTAVAVHPE 244
Cdd:PRK05729 161 RLYEKGLIYRGKRLVNWDPKLQTALSDLEVEYKEVKGKLWHIRYPLA------DGSDYLVVATTRPETMLGDTAVAVNPE 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 245 DERYQALIGKSVILPLANREIPIIADEYVDREFGTGVVKITPAHDFNDYEVGKRHGLPMVNVMTLNADIRAEAEIigtdg 324
Cdd:PRK05729 235 DERYKHLIGKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINIMDEDGTINENPGE----- 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 325 kplsdytapipadYQGLERFAARKKIVADFEALGLLDQIKPHDLKVPYGDRGGVPIEPMLTDQWYVSVKPLAEVATKAVE 404
Cdd:PRK05729 310 -------------YQGLDRFEARKAIVADLEELGLLVKIEPHTHSVGHSDRSGVVIEPYLSDQWFVKMKPLAKPALEAVE 376

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 405 DGEIQFVPKQYENLYFSWMRDIQDWCISRQLWWGHRIPAWYDEQGNVYVARDEAEVRAKHNlpadlpLKQDEDVLDTWFS 484
Cdd:PRK05729 377 NGEIKFVPERWEKTYFHWMENIQDWCISRQLWWGHRIPAWYDEDGEVYVGREEPEAREKAL------LTQDEDVLDTWFS 450

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 485 SGLWTFSTLGWPEQTKELKMFHPTDVLITGFDIIFFWVARMIMFTMHFIKdengkpQVPFKTVYVTGLIRDEQGQKMSKS 564
Cdd:PRK05729 451 SALWPFSTLGWPEKTEDLKRFYPTSVLVTGFDIIFFWVARMIMMGLHFTG------QVPFKDVYIHGLVRDEQGRKMSKS 524

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 565 KGNVLDPIDMIDgislddllekrtgnmmqpqlaekiakatrkefaegivAHGTDALRFTLTALASNGRDINWDMKRLEGY 644
Cdd:PRK05729 525 KGNVIDPLDLID-------------------------------------KYGADALRFTLAALASPGRDIRFDEERVEGY 567

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 645 RNFCNKLWNASRYVLTN---DKLDLSEGDVEFSLADRWIESQFNRTVETFRTALSQYRFDLVANAIYEFTWDQFCDWYLE 721
Cdd:PRK05729 568 RNFANKLWNASRFVLMNlegADVGELPDPEELSLADRWILSRLNRTVAEVTEALDKYRFDEAARALYEFIWNEFCDWYLE 647

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 722 LTKPIFFkgtDVQRRGASRTLVNVLEKLLRLIHPVMPFITEEIWQKVKGfvGIEADTIMLQKFPQFDPlAIDETAESQIN 801
Cdd:PRK05729 648 LAKPVLQ---EAAKRATRATLAYVLEQILRLLHPFMPFITEELWQKLAP--LGIEESIMLAPWPEADE-AIDEAAEAEFE 721

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 802 FIKEVIVAVRNIRAESNIAPSKGLDLIARNFSADEVSILNANEVLLKSMAKLDSVKVLENGENAP-LSVAKLVANGEILI 880
Cdd:PRK05729 722 WLKELITAIRNIRAEMNIPPSKKLPLLLKGADAEDRARLEANEAYIKRLARLESLEILADDEEAPeGAASAVVGGAELFL 801

                        890       900       910       920       930       940       950
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 493291867 881 PMAGFINKEAELARLTKEMDKLKGEVARIEGKLSNEAFVAKAPEQVIAKEREKMQEYLSGLEKLQVQYQEIEA 953
Cdd:PRK05729 802 PLEGLIDVEAELARLEKELAKLEKEIERVEKKLSNEGFVAKAPEEVVEKEREKLAEYEEKLAKLKERLARLKA 874
valS TIGR00422
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ...
 7-933 0e+00

valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273070 [Multi-domain]  Cd Length: 861  Bit Score: 1363.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867    7 MEDRFNPSAVEQALYQHWESQGYFKPSEDINAPSYCIAIPPPNVTGSLHMGHAFQQTLMDTLIRFNRMEGNNTLWQTGTD 86
Cdd:TIGR00422   1 MPKDYDPHEVEKKWYKKWEKSGFFKPDGNSNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGTD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867   87 HAGIATQMVVERKIAAEeGKTRHDYGREAFINKIWDWKAYSGGTISQQMRRLGNSIDWDRERFTMDEGLSNAVKEVFVRL 166
Cdd:TIGR00422  81 HAGIATQVKVEKKLGAE-GKTKHDLGREEFREKIWEWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAFVRL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  167 HEEGLIYRGKRLVNWDPKLHTAISDLEVENKESKGSLWHFRYPLANGAKtadglDYLVVATTRPETMLGDTAVAVHPEDE 246
Cdd:TIGR00422 160 YEKGLIYRGEYLVNWDPKLNTAISDIEVEYKEVKGKLYYIRYPLANGSK-----DYLVVATTRPETMFGDTAVAVHPEDE 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  247 RYQALIGKSVILPLANREIPIIADEYVDREFGTGVVKITPAHDFNDYEVGKRHGLPMVNVMTLNADIRAEAeiigtdgkp 326
Cdd:TIGR00422 235 RYKHLIGKKVILPLTGRKIPIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLEFINILDEDGLLNENA--------- 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  327 lsdytapipADYQGLERFAARKKIVADFEALGLLDQIKPHDLKVPYGDRGGVPIEPMLTDQWYVSVKPLAEVATKAVEDG 406
Cdd:TIGR00422 306 ---------GKYQGLTRFEARKKIVEDLKEEGLLVKIEPHTHNVGTCWRSGTVVEPLLSKQWFVKVEKLADKALEAAEEG 376

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  407 EIQFVPKQYENLYFSWMRDIQDWCISRQLWWGHRIPAWY-DEQGNVYVARDEAEVRAKHNLPADLPLKQDEDVLDTWFSS 485
Cdd:TIGR00422 377 EIKFVPKRMEKRYLNWLRNIKDWCISRQLIWGHRIPVWYcKECGEVYVAKEEPLPDDKTNTGPSVELEQDTDVLDTWFSS 456

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  486 GLWTFSTLGWPEQTKELKMFHPTDVLITGFDIIFFWVARMIMFTMHFIKdengkpQVPFKTVYVTGLIRDEQGQKMSKSK 565
Cdd:TIGR00422 457 SLWPFSTLGWPDETKDLKKFYPTDLLVTGYDIIFFWVARMIFRSLALTG------QVPFKEVYIHGLVRDEQGRKMSKSL 530

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  566 GNVLDPIDMIDgislddllekrtgnmmqpqlaekiakatrkefaegivAHGTDALRFTLTALASNGRDINWDMKRLEGYR 645
Cdd:TIGR00422 531 GNVIDPLDVIE-------------------------------------KYGADALRFTLASLVTPGDDINFDWKRVESAR 573

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  646 NFCNKLWNASRYVLTN--DKLDLSEGDVEFSLADRWIESQFNRTVETFRTALSQYRFDLVANAIYEFTWDQFCDWYLELT 723
Cdd:TIGR00422 574 NFLNKLWNASRFVLMNlsDDLELSGGEEKLSLADRWILSKLNRTIKEVRKALDKYRFAEAAKALYEFIWNDFCDWYIELV 653

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  724 KPIFFKGTDVQRRGASRTLVNVLEKLLRLIHPVMPFITEEIWQKVKGFvgieADTIMLQKFPQFDPLAIDETAESQINFI 803
Cdd:TIGR00422 654 KYRLYNGNEAEKKAARDTLYYVLDKALRLLHPFMPFITEEIWQHFKEG----ADSIMLQSYPVVDAEFVDEEAEKAFELL 729

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  804 KEVIVAVRNIRAESNIAPSKGLDLIARNFSADEVSILNANEVLLKSMAKLDSVKVLENGENAPLSVAKLVANGEILIPMA 883
Cdd:TIGR00422 730 KEIIVSIRNLKAESNIPPNAPLKVLLIYTEAETAERLKLNAVDIKGAINFSEVEVVIEKPEVTEAVVELVPGFEIIIPVK 809

                         890       900       910       920       930
                  ....*....|....*....|....*....|....*....|....*....|
gi 493291867  884 GFINKEAELARLTKEMDKLKGEVARIEGKLSNEAFVAKAPEQVIAKEREK 933
Cdd:TIGR00422 810 GLINKAKELARLQKQLDKEKKEVIRIEGKLENEGFVKKAPKEVIEKEKEK 859
tRNA-synt_1 pfam00133
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ...
 19-637 0e+00

tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.


Pssm-ID: 459685 [Multi-domain]  Cd Length: 602  Bit Score: 811.64  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867   19 ALYQHWESQGYFKPS--EDINAPSYCIAIPPPNVTGSLHMGHAFQQTLMDTLIRFNRMEGNNTLWQTGTDHAGIATQMVV 96
Cdd:pfam00133   1 QIYEFWDEQGYFKPEleKRKGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867   97 ERKIAAEEGKTRHDYGREAFINKIWDWKAYSGGTISQQMRRLGNSIDWDRERFTMDEGLSNAVKEVFVRLHEEGLIYRGK 176
Cdd:pfam00133  81 EKKLGIKEKKTRHKYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  177 RLVNWDPKLHTAISDLEVENKESKGSLWHFRYPLANGAKTadgldYLVVATTRPETMLGDTAVAVHPE------------ 244
Cdd:pfam00133 161 KLVNWSPALNTALSNLEVEYKDVKGPSIHVAFPLADDEGA-----SLVIWTTTPWTLPGNTAVAVNPEfdyvitgegyil 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  245 -------------------DERYQALIGKSVILPLANREIPIIADEYVDREFGTGVVKITPAHDFNDYEVGKRHGLPMVN 305
Cdd:pfam00133 236 aeallkslykkgtdkkileDFRGKELEGKEAIHPFVNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVGQRHNLEVIN 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  306 VMTLNADIRAEAeiigtdgkplsdytapipADYQGLERFAARKKIVADFEALGLLDQIKPHDLKVPYGDRGGVPIEPMLT 385
Cdd:pfam00133 316 PVDDDGTFTEEA------------------PDFQGVYRFDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPIIPRAT 377

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  386 DQWYVSVKPLAEVATKAVEDgeIQFVPKQYENLYFSWMRDIQDWCISRQLWWGHRIPAWYDEQ-GNVYVARDEAEVRAKH 464
Cdd:pfam00133 378 PQWFVRMDELADQALEAVEK--VQFVPKSGEKRYFNWLANIQDWCISRQRWWGHPIPAWVSKDtEEVVCRGELFELVAGR 455

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  465 NLPAD-----------------LPLKQDEDVLDTWFSSGLWTFSTLGWPEQ-TKELKMFHPTDVLITGFDIIFFWVARMI 526
Cdd:pfam00133 456 FEEEGsikwlhreakdklgygkGTLEQDEDVLDTWFSSGSWPFSTLGWPFVnTEEFKKFFPADMLLEGSDQTRGWFYRMI 535

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  527 MFTMHFIKDengkpqVPFKTVYVTGLIRDEQGQKMSKSKGNVLDPIDMIDgislddllekrtgnmmqpqlaekiakatrk 606
Cdd:pfam00133 536 MLSTALTGS------VPFKNVLVHGLVRDEQGRKMSKSLGNVIDPLDVID------------------------------ 579

                         650       660       670
                  ....*....|....*....|....*....|.
gi 493291867  607 efaegivAHGTDALRFTLtALASNGRDINWD 637
Cdd:pfam00133 580 -------KYGADALRLWL-ANSDYGRDINLS 602
ValRS_core cd00817
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ...
 39-636 0e+00

catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 185677 [Multi-domain]  Cd Length: 382  Bit Score: 561.48  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  39 PSYCIAIPPPNVTGSLHMGHAFQQTLMDTLIRFNRMEGNNTLWQTGTDHAGIATQMVVERKIAAEeGKTRHDYGREAFIN 118
Cdd:cd00817    1 PVFVIDTPPPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLGIE-GKTRHDLGREEFLE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 119 KIWDWKAYSGGTISQQMRRLGNSIDWDRERFTMDEGLSNAVKEVFVRLHEEGLIYRGKRLVNWDPKLHTAISDLEVenke 198
Cdd:cd00817   80 KCWEWKEESGGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV---- 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 199 skgslwhfryplangaktadgldylvvattrpetmlgdtavavhpederyqaligksvilplanreipiiadeyvdrefg 278
Cdd:cd00817      --------------------------------------------------------------------------------

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 279 tgvvkitpahdfndyevgkrhglpmvnvmtlnadiraeaeiigtdgkplsdytapipadyqglerfaarkkivadfealg 358
Cdd:cd00817      --------------------------------------------------------------------------------

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 359 lldqikphdlkvpyGDRGGVPIEPMLTDQWYVSVKPLAEVATKAVEDGEIQFVPKQYENLYFSWMRDIQDWCISRQLWWG 438
Cdd:cd00817  156 --------------CSRSGDVIEPLLKPQWFVKVKDLAKKALEAVKEGDIKFVPERMEKRYENWLENIRDWCISRQLWWG 221

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 439 HRIPAWYDEQGN-VYVARDEAEVRAKHNLPADLP-----LKQDEDVLDTWFSSGLWTFSTLGWPEQTKELKMFHPTDVLI 512
Cdd:cd00817  222 HRIPAWYCKDGGhWVVAREEDEAIDKAAPEACVPcggeeLKQDEDVLDTWFSSSLWPFSTLGWPEETKDLKKFYPTSLLV 301

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 513 TGFDIIFFWVARMIMFTMHFIKdengkpQVPFKTVYVTGLIRDEQGQKMSKSKGNVLDPIDMIDGIslddllekrtgnmm 592
Cdd:cd00817  302 TGHDIIFFWVARMIMRGLKLTG------KLPFKEVYLHGLVRDEDGRKMSKSLGNVIDPLDVIDGY-------------- 361

                        570       580       590       600
                 ....*....|....*....|....*....|....*....|....
gi 493291867 593 qpqlaekiakatrkefaegivahGTDALRFTLTALASNGRDINW 636
Cdd:cd00817  362 -----------------------GADALRFTLASAATQGRDINL 382
GatD cd08962
GatD subunit of archaeal Glu-tRNA amidotransferase; GatD is involved in the alternative ...
 592-628 3.26e-04

GatD subunit of archaeal Glu-tRNA amidotransferase; GatD is involved in the alternative synthesis of Gln-tRNA(Gln) in archaea via the transamidation of incorrectly charged Glu-tRNA(Gln). GatD is active as a dimer, and it provides the amino group required for this reaction. GatD is related to bacterial L-asparaginases (amidohydrolases), which catalyze the hydrolysis of asparagine to aspartic acid and ammonia. This CD spans both the L-asparaginase_like domain and an N-terminal supplementary domain.


Pssm-ID: 199206 [Multi-domain]  Cd Length: 402  Bit Score: 44.15  E-value: 3.26e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 493291867 592 MQPQLAEKIAKATRKEFAEG----IVAHGTDALRFTLTALA 628
Cdd:cd08962  128 MTPEYWVKIAEAVYKEIKEGadgvVVAHGTDTMHYTASALS 168
PRK04183 PRK04183
Glu-tRNA(Gln) amidotransferase subunit GatD;
592-628 7.60e-04

Glu-tRNA(Gln) amidotransferase subunit GatD;


Pssm-ID: 235245 [Multi-domain]  Cd Length: 419  Bit Score: 42.91  E-value: 7.60e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 493291867 592 MQPQLAEKIAKATRKEFAEG----IVAHGTDALRFTLTALA 628
Cdd:PRK04183 133 MTPEYWVEIAEAVYEEIKNGadgvVVAHGTDTMHYTAAALS 173
 
Name Accession Description Interval E-value
ValS COG0525
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ...
 7-952 0e+00

Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 440291 [Multi-domain]  Cd Length: 877  Bit Score: 1657.10  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867   7 MEDRFNPSAVEQALYQHWESQGYFKPSEDINAPSYCIAIPPPNVTGSLHMGHAFQQTLMDTLIRFNRMEGNNTLWQTGTD 86
Cdd:COG0525    3 LPKTYDPKEVEAKWYQYWEENGYFKADPDSDKEPFTIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLWQPGTD 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  87 HAGIATQMVVERKIAaEEGKTRHDYGREAFINKIWDWKAYSGGTISQQMRRLGNSIDWDRERFTMDEGLSNAVKEVFVRL 166
Cdd:COG0525   83 HAGIATQAVVERQLA-EEGKSRHDLGREKFLERVWEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKAVREVFVRL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 167 HEEGLIYRGKRLVNWDPKLHTAISDLEVENKESKGSLWHFRYPLAngaktaDGLDYLVVATTRPETMLGDTAVAVHPEDE 246
Cdd:COG0525  162 YEKGLIYRGKRLVNWDPKLKTALSDLEVEHEEVKGHLWHIRYPLA------DGSGYIVVATTRPETMLGDTAVAVHPEDE 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 247 RYQALIGKSVILPLANREIPIIADEYVDREFGTGVVKITPAHDFNDYEVGKRHGLPMVNVMTLNADIRAEAEIigtdgkp 326
Cdd:COG0525  236 RYKHLIGKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINILDEDGTINENAGK------- 308

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 327 lsdytapipadYQGLERFAARKKIVADFEALGLLDQIKPHDLKVPYGDRGGVPIEPMLTDQWYVSVKPLAEVATKAVEDG 406
Cdd:COG0525  309 -----------YRGLDRFEARKAIVADLEELGLLVKVEPHKHSVGHSDRSGTVIEPYLSDQWFVKMKPLAKPAIEAVEDG 377

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 407 EIQFVPKQYENLYFSWMRDIQDWCISRQLWWGHRIPAWYDEQGNVYVARDEAEVRAKHnlpADLPLKQDEDVLDTWFSSG 486
Cdd:COG0525  378 EIKFVPERWEKTYFHWMENIRDWCISRQLWWGHRIPAWYCPDGEVYVARTEPEACAKA---GSVNLTQDEDVLDTWFSSA 454

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 487 LWTFSTLGWPEQTKELKMFHPTDVLITGFDIIFFWVARMIMFTMHFIKdengkpQVPFKTVYVTGLIRDEQGQKMSKSKG 566
Cdd:COG0525  455 LWPFSTLGWPEKTEDLKYFYPTSVLVTGFDIIFFWVARMIMMGLHFTG------EVPFKDVYIHGLVRDEQGRKMSKSKG 528

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 567 NVLDPIDMIDgislddllekrtgnmmqpqlaekiakatrkefaegivAHGTDALRFTLTALASNGRDINWDMKRLEGYRN 646
Cdd:COG0525  529 NVIDPLDLID-------------------------------------KYGADALRFTLAALASPGRDIKFDEERVEGYRN 571

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 647 FCNKLWNASRYVLTN---DKLDLSEGDVEFSLADRWIESQFNRTVETFRTALSQYRFDLVANAIYEFTWDQFCDWYLELT 723
Cdd:COG0525  572 FANKLWNASRFVLMNlegFDPGLDPDPEELSLADRWILSRLNKTIAEVTEALEKYRFDEAAQALYDFVWNEFCDWYLELA 651

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 724 KPIFFKGTDVQRRGASRTLVNVLEKLLRLIHPVMPFITEEIWQKVKGfvGIEADTIMLQKFPQFDPLAIDETAESQINFI 803
Cdd:COG0525  652 KPRLYGGDEAAKRETRATLVYVLEQILRLLHPFMPFITEEIWQKLPP--RKEGESIMLAPWPEADEELIDEEAEAEFEWL 729

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 804 KEVIVAVRNIRAESNIAPSKGLDLIARNFSADEVSILNANEVLLKSMAKLDSVKVLENgENAPLSVAKLVANGEILIPMA 883
Cdd:COG0525  730 KEVISAIRNIRAEMNIPPSKKLPLLLKGADEADRARLEENAAYIKRLARLEEITILVD-EKPEGAASAVVGGAEVFLPLE 808

                        890       900       910       920       930       940
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 493291867 884 GFINKEAELARLTKEMDKLKGEVARIEGKLSNEAFVAKAPEQVIAKEREKMQEYLSGLEKLQVQYQEIE 952
Cdd:COG0525  809 GLIDVEAERARLEKELAKLEKEIARVEKKLSNEGFVAKAPAEVVEKEREKLAEAEAKLEKLEEQLARLK 877
valS PRK05729
valyl-tRNA synthetase; Reviewed
 5-953 0e+00

valyl-tRNA synthetase; Reviewed


Pssm-ID: 235582 [Multi-domain]  Cd Length: 874  Bit Score: 1608.24  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867   5 FTMEDRFNPSAVEQALYQHWESQGYFKPSEDiNAPSYCIAIPPPNVTGSLHMGHAFQQTLMDTLIRFNRMEGNNTLWQTG 84
Cdd:PRK05729   3 MELPKTYDPKEVEAKWYQKWEEKGYFKPDDN-SKKPFSIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLWLPG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  85 TDHAGIATQMVVERKIAAEeGKTRHDYGREAFINKIWDWKAYSGGTISQQMRRLGNSIDWDRERFTMDEGLSNAVKEVFV 164
Cdd:PRK05729  82 TDHAGIATQMVVERQLAAE-GKSRHDLGREKFLEKVWEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKAVREVFV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 165 RLHEEGLIYRGKRLVNWDPKLHTAISDLEVENKESKGSLWHFRYPLAngaktaDGLDYLVVATTRPETMLGDTAVAVHPE 244
Cdd:PRK05729 161 RLYEKGLIYRGKRLVNWDPKLQTALSDLEVEYKEVKGKLWHIRYPLA------DGSDYLVVATTRPETMLGDTAVAVNPE 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 245 DERYQALIGKSVILPLANREIPIIADEYVDREFGTGVVKITPAHDFNDYEVGKRHGLPMVNVMTLNADIRAEAEIigtdg 324
Cdd:PRK05729 235 DERYKHLIGKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINIMDEDGTINENPGE----- 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 325 kplsdytapipadYQGLERFAARKKIVADFEALGLLDQIKPHDLKVPYGDRGGVPIEPMLTDQWYVSVKPLAEVATKAVE 404
Cdd:PRK05729 310 -------------YQGLDRFEARKAIVADLEELGLLVKIEPHTHSVGHSDRSGVVIEPYLSDQWFVKMKPLAKPALEAVE 376

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 405 DGEIQFVPKQYENLYFSWMRDIQDWCISRQLWWGHRIPAWYDEQGNVYVARDEAEVRAKHNlpadlpLKQDEDVLDTWFS 484
Cdd:PRK05729 377 NGEIKFVPERWEKTYFHWMENIQDWCISRQLWWGHRIPAWYDEDGEVYVGREEPEAREKAL------LTQDEDVLDTWFS 450

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 485 SGLWTFSTLGWPEQTKELKMFHPTDVLITGFDIIFFWVARMIMFTMHFIKdengkpQVPFKTVYVTGLIRDEQGQKMSKS 564
Cdd:PRK05729 451 SALWPFSTLGWPEKTEDLKRFYPTSVLVTGFDIIFFWVARMIMMGLHFTG------QVPFKDVYIHGLVRDEQGRKMSKS 524

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 565 KGNVLDPIDMIDgislddllekrtgnmmqpqlaekiakatrkefaegivAHGTDALRFTLTALASNGRDINWDMKRLEGY 644
Cdd:PRK05729 525 KGNVIDPLDLID-------------------------------------KYGADALRFTLAALASPGRDIRFDEERVEGY 567

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 645 RNFCNKLWNASRYVLTN---DKLDLSEGDVEFSLADRWIESQFNRTVETFRTALSQYRFDLVANAIYEFTWDQFCDWYLE 721
Cdd:PRK05729 568 RNFANKLWNASRFVLMNlegADVGELPDPEELSLADRWILSRLNRTVAEVTEALDKYRFDEAARALYEFIWNEFCDWYLE 647

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 722 LTKPIFFkgtDVQRRGASRTLVNVLEKLLRLIHPVMPFITEEIWQKVKGfvGIEADTIMLQKFPQFDPlAIDETAESQIN 801
Cdd:PRK05729 648 LAKPVLQ---EAAKRATRATLAYVLEQILRLLHPFMPFITEELWQKLAP--LGIEESIMLAPWPEADE-AIDEAAEAEFE 721

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 802 FIKEVIVAVRNIRAESNIAPSKGLDLIARNFSADEVSILNANEVLLKSMAKLDSVKVLENGENAP-LSVAKLVANGEILI 880
Cdd:PRK05729 722 WLKELITAIRNIRAEMNIPPSKKLPLLLKGADAEDRARLEANEAYIKRLARLESLEILADDEEAPeGAASAVVGGAELFL 801

                        890       900       910       920       930       940       950
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 493291867 881 PMAGFINKEAELARLTKEMDKLKGEVARIEGKLSNEAFVAKAPEQVIAKEREKMQEYLSGLEKLQVQYQEIEA 953
Cdd:PRK05729 802 PLEGLIDVEAELARLEKELAKLEKEIERVEKKLSNEGFVAKAPEEVVEKEREKLAEYEEKLAKLKERLARLKA 874
valS TIGR00422
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ...
 7-933 0e+00

valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273070 [Multi-domain]  Cd Length: 861  Bit Score: 1363.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867    7 MEDRFNPSAVEQALYQHWESQGYFKPSEDINAPSYCIAIPPPNVTGSLHMGHAFQQTLMDTLIRFNRMEGNNTLWQTGTD 86
Cdd:TIGR00422   1 MPKDYDPHEVEKKWYKKWEKSGFFKPDGNSNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGTD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867   87 HAGIATQMVVERKIAAEeGKTRHDYGREAFINKIWDWKAYSGGTISQQMRRLGNSIDWDRERFTMDEGLSNAVKEVFVRL 166
Cdd:TIGR00422  81 HAGIATQVKVEKKLGAE-GKTKHDLGREEFREKIWEWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAFVRL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  167 HEEGLIYRGKRLVNWDPKLHTAISDLEVENKESKGSLWHFRYPLANGAKtadglDYLVVATTRPETMLGDTAVAVHPEDE 246
Cdd:TIGR00422 160 YEKGLIYRGEYLVNWDPKLNTAISDIEVEYKEVKGKLYYIRYPLANGSK-----DYLVVATTRPETMFGDTAVAVHPEDE 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  247 RYQALIGKSVILPLANREIPIIADEYVDREFGTGVVKITPAHDFNDYEVGKRHGLPMVNVMTLNADIRAEAeiigtdgkp 326
Cdd:TIGR00422 235 RYKHLIGKKVILPLTGRKIPIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLEFINILDEDGLLNENA--------- 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  327 lsdytapipADYQGLERFAARKKIVADFEALGLLDQIKPHDLKVPYGDRGGVPIEPMLTDQWYVSVKPLAEVATKAVEDG 406
Cdd:TIGR00422 306 ---------GKYQGLTRFEARKKIVEDLKEEGLLVKIEPHTHNVGTCWRSGTVVEPLLSKQWFVKVEKLADKALEAAEEG 376

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  407 EIQFVPKQYENLYFSWMRDIQDWCISRQLWWGHRIPAWY-DEQGNVYVARDEAEVRAKHNLPADLPLKQDEDVLDTWFSS 485
Cdd:TIGR00422 377 EIKFVPKRMEKRYLNWLRNIKDWCISRQLIWGHRIPVWYcKECGEVYVAKEEPLPDDKTNTGPSVELEQDTDVLDTWFSS 456

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  486 GLWTFSTLGWPEQTKELKMFHPTDVLITGFDIIFFWVARMIMFTMHFIKdengkpQVPFKTVYVTGLIRDEQGQKMSKSK 565
Cdd:TIGR00422 457 SLWPFSTLGWPDETKDLKKFYPTDLLVTGYDIIFFWVARMIFRSLALTG------QVPFKEVYIHGLVRDEQGRKMSKSL 530

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  566 GNVLDPIDMIDgislddllekrtgnmmqpqlaekiakatrkefaegivAHGTDALRFTLTALASNGRDINWDMKRLEGYR 645
Cdd:TIGR00422 531 GNVIDPLDVIE-------------------------------------KYGADALRFTLASLVTPGDDINFDWKRVESAR 573

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  646 NFCNKLWNASRYVLTN--DKLDLSEGDVEFSLADRWIESQFNRTVETFRTALSQYRFDLVANAIYEFTWDQFCDWYLELT 723
Cdd:TIGR00422 574 NFLNKLWNASRFVLMNlsDDLELSGGEEKLSLADRWILSKLNRTIKEVRKALDKYRFAEAAKALYEFIWNDFCDWYIELV 653

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  724 KPIFFKGTDVQRRGASRTLVNVLEKLLRLIHPVMPFITEEIWQKVKGFvgieADTIMLQKFPQFDPLAIDETAESQINFI 803
Cdd:TIGR00422 654 KYRLYNGNEAEKKAARDTLYYVLDKALRLLHPFMPFITEEIWQHFKEG----ADSIMLQSYPVVDAEFVDEEAEKAFELL 729

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  804 KEVIVAVRNIRAESNIAPSKGLDLIARNFSADEVSILNANEVLLKSMAKLDSVKVLENGENAPLSVAKLVANGEILIPMA 883
Cdd:TIGR00422 730 KEIIVSIRNLKAESNIPPNAPLKVLLIYTEAETAERLKLNAVDIKGAINFSEVEVVIEKPEVTEAVVELVPGFEIIIPVK 809

                         890       900       910       920       930
                  ....*....|....*....|....*....|....*....|....*....|
gi 493291867  884 GFINKEAELARLTKEMDKLKGEVARIEGKLSNEAFVAKAPEQVIAKEREK 933
Cdd:TIGR00422 810 GLINKAKELARLQKQLDKEKKEVIRIEGKLENEGFVKKAPKEVIEKEKEK 859
PTZ00419 PTZ00419
valyl-tRNA synthetase-like protein; Provisional
 7-954 0e+00

valyl-tRNA synthetase-like protein; Provisional


Pssm-ID: 240411 [Multi-domain]  Cd Length: 995  Bit Score: 1071.94  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867   7 MEDRFNPSAVEQALYQHWESQGYFKPSEDINAPS----YCIAIPPPNVTGSLHMGHAFQQTLMDTLIRFNRMEGNNTLWQ 82
Cdd:PTZ00419  24 MAASYDPKEVESGWYEWWEKSGFFKPAEDAKSLNsgkkFVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDETLWV 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  83 TGTDHAGIATQMVVERKIAAEEGKTRHDYGREAFINKIWDWKAYSGGTISQQMRRLGNSIDWDRERFTMDEGLSNAVKEV 162
Cdd:PTZ00419 104 PGTDHAGIATQVVVEKKLMKEENKTRHDLGREEFLKKVWEWKDKHGNNICNQLRRLGSSLDWSREVFTMDEQRSKAVKEA 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 163 FVRLHEEGLIYRGKRLVNWDPKLHTAISDLEVENKESK----------------GSLWHFRYPLANGaktadGLDYLVVA 226
Cdd:PTZ00419 184 FVRLYEDGLIYRDTRLVNWCCYLKTAISDIEVEFEEIEkptkitipgydkkvevGVLWHFAYPLEDS-----GQEEIVVA 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 227 TTRPETMLGDTAVAVHPEDERYQALIGKSVILPLAN-REIPIIADE-YVDREFGTGVVKITPAHDFNDYEVGKRHGLPMV 304
Cdd:PTZ00419 259 TTRIETMLGDVAVAVHPKDERYKKLHGKELIHPFIPdRKIPIIADDeLVDMEFGTGAVKITPAHDPNDYEIAKRHNLPFI 338

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 305 NVMTLNADiraeaeiIGTDGKPlsdytapipadYQGLERFAARKKIVADFEALGLLDQIKPHDLKVPYGDRGGVPIEPML 384
Cdd:PTZ00419 339 NIFTLDGK-------INENGGE-----------FAGMHRFDCRRKIEEELKEMGLLRDKVPNPMRLPRCSRSGDIVEPML 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 385 TDQWYVSVKPLAEVATKAVEDGEIQFVPKQYENLYFSWMRDIQDWCISRQLWWGHRIPAW----------YDEQGNVYVA 454
Cdd:PTZ00419 401 IPQWYVNCKDMAKRAVEAVRNGELKIIPSSHENVWYHWLENIQDWCISRQLWWGHRIPAYrviskgpetdPSDEEPWVVA 480

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 455 RDEAEVRAK-----HNLPADLPLKQDEDVLDTWFSSGLWTFSTLGWPEQTKELKMFHPTDVLITGFDIIFFWVARMIMFT 529
Cdd:PTZ00419 481 RSEEEALEKakkkfGLSEEDFELEQDEDVLDTWFSSGLFPFSTLGWPDQTDDLQRFFPTSLLETGSDILFFWVARMVMMS 560

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 530 MHFIKdengkpQVPFKTVYVTGLIRDEQGQKMSKSKGNVLDPIDMIDGISLDDLLEK-RTGNMMQPQLaEKIAKATRKEF 608
Cdd:PTZ00419 561 LHLTD------KLPFKTVFLHAMVRDSQGEKMSKSKGNVIDPLEVIEGISLQDLNQKlYEGNLPEKEI-KRAIELQKKEF 633

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 609 AEGIVAHGTDALRFTLTALASNGRDINWDMKRLEGYRNFCNKLWNASRYVLTN--DKLDLSEGDVE-------FSLADRW 679
Cdd:PTZ00419 634 PNGIPECGTDALRFGLLAYTQQGRNINLDINRVVGYRHFCNKLWNAVKFALMKllKDFNLPNSTLFkpnnvesLPWEDKW 713

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 680 IESQFNRTVETFRTALSQYRFDLVANAIYEFTWDQFCDWYLELTKPIFFKGTD-VQRRGASRTLVNVLEKLLRLIHPVMP 758
Cdd:PTZ00419 714 ILHRLNVAIKEVTEGFKEYDFSEATQATYNFWLYELCDVYLELIKPRLSKQSDgERKQHAQDVLHTVLDIGLRLLHPMMP 793

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 759 FITEEIWQKVKGFVGIEaDTIMLQKFPQFDPLAIDETAESQINFIKEVIVAVRNIRAESNIAPSKGLDLIARNFSADEVS 838
Cdd:PTZ00419 794 FITEELYQRLPNYLRKS-ESISIAKYPQPNPGWNNEALDEEMKIIMSIVKSIRSLIATLGIPNKTKPDCYVTAKDAELIE 872

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 839 ILNANEVLLKSMAKLDSVKVLENGENAPLSVAKL---VANGEILIPM--AGFINKEAELARLTKEMDKLKGEVARIEGKL 913
Cdd:PTZ00419 873 LIESAENLISTLAKIGSVSVIPPIEEEAEVPKGCgfdVVDNKVIIYLnlDEFIDLKKELAKLEKKLAKLQKSLESYLKKI 952

                        970       980       990      1000
                 ....*....|....*....|....*....|....*....|.
gi 493291867 914 SNEAFVAKAPEQVIAKEREKMQEYLSGLEKLQVQYQEIEAL 954
Cdd:PTZ00419 953 SIPNYEDKVPEDVRKLNDEKIDELNEEIKQLEQAIEELKSL 993
valS PRK14900
valyl-tRNA synthetase; Provisional
 7-951 0e+00

valyl-tRNA synthetase; Provisional


Pssm-ID: 237855 [Multi-domain]  Cd Length: 1052  Bit Score: 1017.61  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867    7 MEDR------FNPSAVEQALYQHWESQGYFKPSE-DINAPSYCIAIPPPNVTGSLHMGHAFQQTLMDTLIRFNRMEGNNT 79
Cdd:PRK14900    9 NENRtelakgYEHREVEARWYPFWQERGYFHGDEhDRTRPPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNT 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867   80 LWQTGTDHAGIATQMVVERKIAAEEGKTRHDYGREAFINKIWDWKAYSGGTISQQMRRLGNSIDWDRERFTMDEGLSNAV 159
Cdd:PRK14900   89 LWLPGTDHAGIATQMIVEKELKKTEKKSRHDLGREAFLERVWAWKEQYGSRIGEQHKALGASLDWQRERFTMDEGLSRAV 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  160 KEVFVRLHEEGLIYRGKRLVNWDPKLHTAISDLEVENKESK-GSLWHFRYPLangaktADGLDYLVVATTRPETMLGDTA 238
Cdd:PRK14900  169 REVFVRLHEEGLIYREKKLINWCPDCRTALSDLEVEHEEAHqGELWSFAYPL------ADGSGEIVVATTRPETMLGDTA 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  239 VAVHPEDERYQALIGKSVILPLANREIPIIAD-EYVDREFGTGVVKITPAHDFNDYEVGKRHGLPMVNVmtlnadiraea 317
Cdd:PRK14900  243 VAVHPLDPRYMALHGKKVRHPITGRTFPIVADaILVDPKFGTGAVKVTPAHDFNDFEVGKRHGLEMITV----------- 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  318 eiIGTDGKpLSDYTAPipadYQGLERFAARKKIVADFEALGLLDQIKPHDLKVPYGDRGGVPIEPMLTDQWYVSVKPLAE 397
Cdd:PRK14900  312 --IGPDGR-MTAEAGP----LAGLDRFEARKEVKRLLAEQGLDRGAKPHVLPLGRCQRSATILEPLLSDQWYVRIEPLAR 384

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  398 VATKAVEDGEIQFVPKQYENLYFSWMRDIQDWCISRQLWWGHRIPAWYDEQGNVYVARDEAEVRAKhnlPADLPLKQDED 477
Cdd:PRK14900  385 PAIEAVEQGRTRFIPEQWTNTYMAWMRNIHDWCISRQLWWGHQIPAWYCPDGHVTVARETPEACST---CGKAELRQDED 461

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  478 VLDTWFSSGLWTFSTLGWPEQTKELKMFHPTDVLITGFDIIFFWVARMIMFTMHFIKDengkpqVPFKTVYVTGLIRDEQ 557
Cdd:PRK14900  462 VLDTWFSSGLWPFSTMGWPEQTDTLRTFYPTSVMETGHDIIFFWVARMMMMGLHFMGE------VPFRTVYLHPMVRDEK 535

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  558 GQKMSKSKGNVLDPIDMIDgislddllekrtgnmmqpqlaekiakatrkefaegivAHGTDALRFTLTALASNGRDINWD 637
Cdd:PRK14900  536 GQKMSKTKGNVIDPLVITE-------------------------------------QYGADALRFTLAALTAQGRDIKLA 578

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  638 MKRLEGYRNFCNKLWNASRYVLTN------DKLDLSEgdVEFSLADRWIESQFNRTVETFRTALSQYRFDLVANAIYEFT 711
Cdd:PRK14900  579 KERIEGYRAFANKLWNASRFALMNlsgyqeRGEDPAR--LARTPADRWILARLQRAVNETVEALEAFRFNDAANAVYAFV 656

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  712 WDQFCDWYLELTKPIFFkGTDVQRRGASR-TLVNVLEKLLRLIHPVMPFITEEIWQKVKGFVGIEA--DTIMLQKFPQFD 788
Cdd:PRK14900  657 WHELCDWYIELAKEALA-SEDPEARRSVQaVLVHCLQTSYRLLHPFMPFITEELWHVLRAQVGASAwaDSVLAAEYPRKG 735

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  789 plAIDETAESQINFIKEVIVAVRNIRAESNIAPSKGL----DLIARNFSADEVSILNANEV-LLKSMAKLDSVKVLEN-- 861
Cdd:PRK14900  736 --EADEAAEAAFRPVLGIIDAVRNIRGEMGIPWKVKLgaqaPVEIAVADPALRDLLQAGELaRVHRVAGVEGSRLVVAaa 813

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  862 GENAPLSVAKLVANGEILIPMAGFINKEAELARLTKEMDKLKGEVARIEGKLSNEAFVAKAPEQVIAKEREKMQEYLSGL 941
Cdd:PRK14900  814 TAPAPQSAVGVGPGFEVRVPLAGVIDLAAETARVDKEIGKVDQDLAVLERKLQNPSFVQNAPPAVVEKDRARAEELREKR 893

                         970
                  ....*....|
gi 493291867  942 EKLQVQYQEI 951
Cdd:PRK14900  894 GKLEAHRAML 903
PLN02943 PLN02943
aminoacyl-tRNA ligase
 17-936 0e+00

aminoacyl-tRNA ligase


Pssm-ID: 215509 [Multi-domain]  Cd Length: 958  Bit Score: 846.92  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  17 EQALYQHWESQGYFKPSEDINAPSYCIAIPPPNVTGSLHMGHAFQQTLMDTLIRFNRMEGNNTLWQTGTDHAGIATQMVV 96
Cdd:PLN02943  66 EERIYNWWESQGYFKPNFDRGGDPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGIATQLVV 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  97 ERKIAAEeGKTRHDYGREAFINKIWDWKAYSGGTISQQMRRLGNSIDWDRERFTMDEGLSNAVKEVFVRLHEEGLIYRGK 176
Cdd:PLN02943 146 EKMLASE-GIKRTDLGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEKGLIYQGS 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 177 RLVNWDPKLHTAISDLEVENKESKGSLWHFRYPLANGAKtadglDYLVVATTRPETMLGDTAVAVHPEDERYQALIGKSV 256
Cdd:PLN02943 225 YMVNWSPNLQTAVSDLEVEYSEEPGTLYYIKYRVAGGSE-----DFLTIATTRPETLFGDVAIAVNPEDDRYSKYIGKMA 299

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 257 ILPLA-NREIPIIADEYVDREFGTGVVKITPAHDFNDYEVGKRHGLPMVNVMTLNADIRaeaeiigtdgkplsdytapip 335
Cdd:PLN02943 300 IVPMTyGRHVPIIADRYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMNKDGTLN--------------------- 358

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 336 aDYQGLERFAARKKIVADFEALGLLDQIKPHDLKVPYGDRGGVPIEPMLTDQWYVSVKPLAEVATKAVEDGEIQFVPKQY 415
Cdd:PLN02943 359 -EVAGLYWFEAREKLWSDLEETGLAVKKEPHTLRVPRSQRGGEVIEPLVSKQWFVTMEPLAEKALKAVENGELTIIPERF 437

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 416 ENLYFSWMRDIQDWCISRQLWWGHRIPAWY----DEQGNVYVAR--DEAEVRAKHNLPADLPLKQDEDVLDTWFSSGLWT 489
Cdd:PLN02943 438 EKIYNHWLSNIKDWCISRQLWWGHRIPVWYivgkDCEEDYIVARsaEEALEKAREKYGKDVEIYQDPDVLDTWFSSALWP 517

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 490 FSTLGWPE-QTKELKMFHPTDVLITGFDIIFFWVARMIMFTMHFikdeNGKpqVPFKTVYVTGLIRDEQGQKMSKSKGNV 568
Cdd:PLN02943 518 FSTLGWPDvSAEDFKKFYPTTVLETGHDILFFWVARMVMMGIEF----TGT--VPFSYVYLHGLIRDSQGRKMSKTLGNV 591

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 569 LDPIDMIdgislddllekrtgnmmqpqlaekiakatrKEFaegivahGTDALRFTLtALASNGRDINWDMKRLEGYRNFC 648
Cdd:PLN02943 592 IDPLDTI------------------------------KEF-------GTDALRFTL-ALGTAGQDLNLSTERLTSNKAFT 633

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 649 NKLWNASRYVLTN---------------DKLDLSEGDVEFSLADRWIESQFNRTVETFRTALSQYRFDLVANAIYEFTWD 713
Cdd:PLN02943 634 NKLWNAGKFVLQNlpsqsdtsawehilaCKFDKEESLLSLPLPECWVVSKLHELIDSVTTSYDKYFFGDVGREIYDFFWS 713

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 714 QFCDWYLELTKPIFFKGTDVQRRGASRT-LVNVLEKLLRLIHPVMPFITEEIWQKVKGfvgiEADTIMLQKFPQfDPLAI 792
Cdd:PLN02943 714 DFADWYIEASKTRLYHSGDNSALSRAQAvLLYVFENILKLLHPFMPFVTEELWQALPY----RKEALIVSPWPQ-TSLPK 788

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 793 DETAESQINFIKEVIVAVRNIRAESNIAPSKGLDLIARNFSADEVSILNANEVL-LKSMAKLDSVKVLENGE-NAPLSVA 870
Cdd:PLN02943 789 DLKSIKRFENLQSLTRAIRNARAEYSVEPAKRISASIVASAEVIEYISKEKEVLaLLSRLDLQNVHFTDSPPgDANQSVH 868

                        890       900       910       920       930       940
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 493291867 871 KLVANG-EILIPMAGFINKEAELARLTKEMDKLKGEVARIEGKLSNEAFVAKAPEQVIAKEREKMQE 936
Cdd:PLN02943 869 LVASEGlEAYLPLADMVDISAEVERLSKRLSKMQTEYDALAARLSSPKFVEKAPEDVVRGVREKAAE 935
tRNA-synt_1 pfam00133
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ...
 19-637 0e+00

tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.


Pssm-ID: 459685 [Multi-domain]  Cd Length: 602  Bit Score: 811.64  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867   19 ALYQHWESQGYFKPS--EDINAPSYCIAIPPPNVTGSLHMGHAFQQTLMDTLIRFNRMEGNNTLWQTGTDHAGIATQMVV 96
Cdd:pfam00133   1 QIYEFWDEQGYFKPEleKRKGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867   97 ERKIAAEEGKTRHDYGREAFINKIWDWKAYSGGTISQQMRRLGNSIDWDRERFTMDEGLSNAVKEVFVRLHEEGLIYRGK 176
Cdd:pfam00133  81 EKKLGIKEKKTRHKYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  177 RLVNWDPKLHTAISDLEVENKESKGSLWHFRYPLANGAKTadgldYLVVATTRPETMLGDTAVAVHPE------------ 244
Cdd:pfam00133 161 KLVNWSPALNTALSNLEVEYKDVKGPSIHVAFPLADDEGA-----SLVIWTTTPWTLPGNTAVAVNPEfdyvitgegyil 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  245 -------------------DERYQALIGKSVILPLANREIPIIADEYVDREFGTGVVKITPAHDFNDYEVGKRHGLPMVN 305
Cdd:pfam00133 236 aeallkslykkgtdkkileDFRGKELEGKEAIHPFVNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVGQRHNLEVIN 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  306 VMTLNADIRAEAeiigtdgkplsdytapipADYQGLERFAARKKIVADFEALGLLDQIKPHDLKVPYGDRGGVPIEPMLT 385
Cdd:pfam00133 316 PVDDDGTFTEEA------------------PDFQGVYRFDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPIIPRAT 377

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  386 DQWYVSVKPLAEVATKAVEDgeIQFVPKQYENLYFSWMRDIQDWCISRQLWWGHRIPAWYDEQ-GNVYVARDEAEVRAKH 464
Cdd:pfam00133 378 PQWFVRMDELADQALEAVEK--VQFVPKSGEKRYFNWLANIQDWCISRQRWWGHPIPAWVSKDtEEVVCRGELFELVAGR 455

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  465 NLPAD-----------------LPLKQDEDVLDTWFSSGLWTFSTLGWPEQ-TKELKMFHPTDVLITGFDIIFFWVARMI 526
Cdd:pfam00133 456 FEEEGsikwlhreakdklgygkGTLEQDEDVLDTWFSSGSWPFSTLGWPFVnTEEFKKFFPADMLLEGSDQTRGWFYRMI 535

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  527 MFTMHFIKDengkpqVPFKTVYVTGLIRDEQGQKMSKSKGNVLDPIDMIDgislddllekrtgnmmqpqlaekiakatrk 606
Cdd:pfam00133 536 MLSTALTGS------VPFKNVLVHGLVRDEQGRKMSKSLGNVIDPLDVID------------------------------ 579

                         650       660       670
                  ....*....|....*....|....*....|.
gi 493291867  607 efaegivAHGTDALRFTLtALASNGRDINWD 637
Cdd:pfam00133 580 -------KYGADALRLWL-ANSDYGRDINLS 602
PLN02381 PLN02381
valyl-tRNA synthetase
 7-953 0e+00

valyl-tRNA synthetase


Pssm-ID: 215214 [Multi-domain]  Cd Length: 1066  Bit Score: 805.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867    7 MEDRFNPSAVEQALYQHWESQGYFKPSEDINAPSYCIAIPPPNVTGSLHMGHAFQQTLMDTLIRFNRMEGNNTLWQTGTD 86
Cdd:PLN02381   96 MAKQYSPSAVEKSWYAWWEKSGYFGADAKSSKPPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVPGVD 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867   87 HAGIATQMVVERKIAAEEGKTRHDYGREAFINKIWDWKAYSGGTISQQMRRLGNSIDWDRERFTMDEGLSNAVKEVFVRL 166
Cdd:PLN02381  176 HAGIATQVVVEKKLMRERHLTRHDIGREEFVSEVWKWKDEYGGTILNQLRRLGASLDWSRECFTMDEQRSKAVTEAFVRL 255

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  167 HEEGLIYRGKRLVNWDPKLHTAISDLEVEN---KESK-------------GSLWHFRYPLangaktADGLDYLVVATTRP 230
Cdd:PLN02381  256 YKEGLIYRDIRLVNWDCTLRTAISDVEVDYidiKERTllkvpgydkpvefGVLTSFAYPL------EGGLGEIVVATTRI 329

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  231 ETMLGDTAVAVHPEDERYQALIGKSVILPLANREIPIIAD-EYVDREFGTGVVKITPAHDFNDYEVGKRHGLPMVNVMTl 309
Cdd:PLN02381  330 ETMLGDTAIAIHPDDERYKHLHGKFAVHPFNGRKLPIICDaILVDPNFGTGAVKITPAHDPNDFEVGKRHNLEFINIFT- 408

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  310 nadiraeaeiigTDGKPLSDYTapipADYQGLERFAARKKIVADFEALGLLDQIKPHDLKVPYGDRGGVPIEPMLTDQWY 389
Cdd:PLN02381  409 ------------DDGKINSNGG----SEFAGMPRFAAREAVIEALQKKGLYRGAKNNEMRLGLCSRTNDVVEPMIKPQWF 472

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  390 VSVKPLAEVATKAVEDGE---IQFVPKQYENLYFSWMRDIQDWCISRQLWWGHRIPAWY-----DEQGNV-------YVA 454
Cdd:PLN02381  473 VNCSSMAKQALDAAIDGEnkkLEFIPKQYLAEWKRWLENIRDWCISRQLWWGHRIPAWYvtledDQLKELgsyndhwVVA 552

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  455 RDEAEVRAKHNLP---ADLPLKQDEDVLDTWFSSGLWTFSTLGWPEQTKELKMFHPTDVLITGFDIIFFWVARMIMFTMH 531
Cdd:PLN02381  553 RNESDALLEASQKfpgKKFELSQDPDVLDTWFSSGLFPLSVLGWPDDTDDLKAFYPTSVLETGHDILFFWVARMVMMGMQ 632

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  532 FIKDengkpqVPFKTVYVTGLIRDEQGQKMSKSKGNVLDPIDMIDGISLDDLLEK-RTGNMMQPQLAekIAKA-TRKEFA 609
Cdd:PLN02381  633 LGGD------VPFRKVYLHPMIRDAHGRKMSKSLGNVIDPLEVINGISLEGLHKRlEEGNLDPKELV--VAKEgQKKDFP 704

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  610 EGIVAHGTDALRFTLTALASNGRDINWDMKRLEGYRNFCNKLWNASRYVLTndKLD--------LSEGDVEFSLadRWIE 681
Cdd:PLN02381  705 NGIAECGTDALRFALVSYTAQSDKINLDILRVVGYRQWCNKLWNAVRFAMS--KLGddytppatLSVETMPFSC--KWIL 780

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  682 SQFNRTVETFRTALSQYRFDLVANAIYEFTWDQFCDWYLELTKPIFFKGT---DVQRRGASRTLVNVLEKLLRLIHPVMP 758
Cdd:PLN02381  781 SVLNKAISKTVSSLDAYEFSDAASTVYSWWQYQFCDVFIEAIKPYFAGDNpefASERAAAQDTLWICLDTGLRLLHPFMP 860

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  759 FITEEIWQKVKGFVGIE-ADTIMLQKFPQFDPLAIDETAESQINFIKEVIVAVRNIRAESnIAPSKGLDLIARNF-SADE 836
Cdd:PLN02381  861 FVTEELWQRLPQPKDHTrKDSIMISEYPSAVEAWTNEKVEYEMDLVLSTVKCLRSLRAEV-LEKQKNERLPAFALcRNQE 939

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  837 VS-ILNANEVLLKSMAKLDSVKVLENGENAP---LSVAKLVANGEILIPMAGFINKEAELARLTKEMDKLKGEVARIEGK 912
Cdd:PLN02381  940 IAaIIKSHQLEILTLANLSSLKVLLSENDAPpagCAFENVNENLKVYLQAQGAVNAEAELEKLRNKMDEIQKQQEKLEKK 1019

                         970       980       990      1000
                  ....*....|....*....|....*....|....*....|.
gi 493291867  913 LSNEAFVAKAPEQVIAKEREKMQEYLSGLEKLQVQYQEIEA 953
Cdd:PLN02381 1020 MNASGYKEKVPANIQEEDARKLTKLLQELEFFEKESKRLEA 1060
ValRS_core cd00817
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ...
 39-636 0e+00

catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 185677 [Multi-domain]  Cd Length: 382  Bit Score: 561.48  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  39 PSYCIAIPPPNVTGSLHMGHAFQQTLMDTLIRFNRMEGNNTLWQTGTDHAGIATQMVVERKIAAEeGKTRHDYGREAFIN 118
Cdd:cd00817    1 PVFVIDTPPPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLGIE-GKTRHDLGREEFLE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 119 KIWDWKAYSGGTISQQMRRLGNSIDWDRERFTMDEGLSNAVKEVFVRLHEEGLIYRGKRLVNWDPKLHTAISDLEVenke 198
Cdd:cd00817   80 KCWEWKEESGGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV---- 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 199 skgslwhfryplangaktadgldylvvattrpetmlgdtavavhpederyqaligksvilplanreipiiadeyvdrefg 278
Cdd:cd00817      --------------------------------------------------------------------------------

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 279 tgvvkitpahdfndyevgkrhglpmvnvmtlnadiraeaeiigtdgkplsdytapipadyqglerfaarkkivadfealg 358
Cdd:cd00817      --------------------------------------------------------------------------------

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 359 lldqikphdlkvpyGDRGGVPIEPMLTDQWYVSVKPLAEVATKAVEDGEIQFVPKQYENLYFSWMRDIQDWCISRQLWWG 438
Cdd:cd00817  156 --------------CSRSGDVIEPLLKPQWFVKVKDLAKKALEAVKEGDIKFVPERMEKRYENWLENIRDWCISRQLWWG 221

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 439 HRIPAWYDEQGN-VYVARDEAEVRAKHNLPADLP-----LKQDEDVLDTWFSSGLWTFSTLGWPEQTKELKMFHPTDVLI 512
Cdd:cd00817  222 HRIPAWYCKDGGhWVVAREEDEAIDKAAPEACVPcggeeLKQDEDVLDTWFSSSLWPFSTLGWPEETKDLKKFYPTSLLV 301

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 513 TGFDIIFFWVARMIMFTMHFIKdengkpQVPFKTVYVTGLIRDEQGQKMSKSKGNVLDPIDMIDGIslddllekrtgnmm 592
Cdd:cd00817  302 TGHDIIFFWVARMIMRGLKLTG------KLPFKEVYLHGLVRDEDGRKMSKSLGNVIDPLDVIDGY-------------- 361

                        570       580       590       600
                 ....*....|....*....|....*....|....*....|....
gi 493291867 593 qpqlaekiakatrkefaegivahGTDALRFTLTALASNGRDINW 636
Cdd:cd00817  362 -----------------------GADALRFTLASAATQGRDINL 382
valS PRK13208
valyl-tRNA synthetase; Reviewed
 6-863 0e+00

valyl-tRNA synthetase; Reviewed


Pssm-ID: 237306 [Multi-domain]  Cd Length: 800  Bit Score: 558.27  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867   6 TMEDRFNPSAVEQALYQHWESQGYFKPSEDINAPSYCIAIPPPNVTGSLHMGHAFQQTLMDTLIRFNRMEGNNTLWQTGT 85
Cdd:PRK13208   5 ELPKKYDPEELEEKWQKIWEEEGTYKFDPDERKPVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVFFPQGW 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  86 DHAGIATqmvvERKIAAEEGKTRHDYGREAFINKIWDWKAYSGGTISQQMRRLGNSIDWDRERFTMDEGLSNAVKEVFVR 165
Cdd:PRK13208  85 DDNGLPT----ERKVEKYYGIRKDDISREEFIELCRELTDEDEKKFRELWRRLGLSVDWSLEYQTISPEYRRISQKSFLD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 166 LHEEGLIYRGKRLVNWDPKLHTAISDLEVENKESKGSLWHFRYPLANGaktadglDYLVVATTRPETMLGDTAVAVHPED 245
Cdd:PRK13208 161 LYKKGLIYRAEAPVLWCPRCETAIAQAEVEYREREGKLNYIKFPVEDG-------EEIEIATTRPELLPACVAVVVHPDD 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 246 ERYQALIGKSVILPLANREIPIIADEYVDREFGTGVVKITPAHDFNDYEVGKRHGLPMVnvmtlnadiraeaEIIGTDGK 325
Cdd:PRK13208 234 ERYKHLVGKTAIVPLFGVEVPILADPLVDPDFGTGAVMICTFGDKTDVTWWRELNLPTR-------------IIIDEDGR 300

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 326 pLSDYTAPipadYQGLERFAARKKIVADFEALGLLDQIKPHDLKVPYGDRGGVPIEPMLTDQWYVSVKPLAEVATKAVEd 405
Cdd:PRK13208 301 -MTEAAGK----LAGLTIEEARKKIVEDLKSGGLLGKQEPIKHNVKFCERCDTPLEILVTRQWFIKVLDLKEELLERGK- 374

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 406 gEIQFVP----KQYENlyfsWMRDIQ-DWCISRQLWWGHRIPAWY-DEQGNVYVARDEAevrakhnLPADlPLKQ----- 474
Cdd:PRK13208 375 -EINWYPehmrVRLEN----WIEGLNwDWCISRQRYFGTPIPVWYcKDCGHPILPDEED-------LPVD-PTKDeppgy 441

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 475 ------------DEDVLDTWFSSGL-WTFSTlGWPEQTKELKMFHPTDVLITGFDIIFFW----VARMIMftmhfikdEN 537
Cdd:PRK13208 442 kcpqcgspgfegETDVMDTWATSSItPLIVT-GWERDEDLFEKVFPMDLRPQGHDIIRTWlfytILRAYL--------LT 512

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 538 GKpqVPFKTVYVTGLIRDEQGQKMSKSKGNVLDPidmidgislDDLLEKrtgnmmqpqlaekiakatrkefaegivaHGT 617
Cdd:PRK13208 513 GK--LPWKNIMISGMVLDPDGKKMSKSKGNVVTP---------EELLEK----------------------------YGA 553

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 618 DALRFTlTALASNGRDINWDMKRLEGYRNFCNKLWNASRYVLTNDKLDLSEGDVEFSLADRWIESQFNRTVETFRTALSQ 697
Cdd:PRK13208 554 DAVRYW-AASARLGSDTPFDEKQVKIGRRLLTKLWNASRFVLHFSADPEPDKAEVLEPLDRWILAKLAKVVEKATEALEN 632

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 698 YRFDLVANAIYEFTWDQFCDWYLELTKP-IFFKGTDVQRRGASRTLVNVLEKLLRLIHPVMPFITEEIWQKVKGfvgiea 776
Cdd:PRK13208 633 YDFAKALEEIESFFWHVFCDDYLELVKSrAYGEDEEEEQKSARYTLYTVLDTLLRLLAPFLPFITEEVWSWLYG------ 706

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 777 DTIMLQKFPQFDPLAIDETAESQINFIKEVIVAVRNIRAESNI---APSKGLDLIArnfsADEVSILNANEVLLKSMAKL 853
Cdd:PRK13208 707 GSVHRASWPEPDEELIDEEDEELGELAKEILSAVRKYKSEAGLslnAPLKKVEVYG----PADLELLEAAEEDLKAAGNI 782

                        890
                 ....*....|
gi 493291867 854 DSVKVLENGE 863
Cdd:PRK13208 783 EELELVEGDP 792
IleS COG0060
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ...
 5-816 1.21e-106

Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439830 [Multi-domain]  Cd Length: 931  Bit Score: 352.46  E-value: 1.21e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867   5 FTMedRFNPSAVEQALYQHWESQGYFKPSEDINAPSyciaiP-------PPNVTGSLHMGHAFQQTLMDTLIRFNRMEGN 77
Cdd:COG0060   12 FPM--RANLPKREPEILKFWEENDIYEKSREARAGR-----PkfvlhdgPPYANGDIHIGHALNKILKDIIVRYKTMRGF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  78 NTLWQTGTD-HaGiatqMVVERKIAAEEGKTR---HDYGREAFINKIwdwKAYSGGTISQQM---RRLGNSIDWDRERFT 150
Cdd:COG0060   85 DVPYVPGWDcH-G----LPIELKVEKELGIKKkdiEKVGIAEFREKC---REYALKYVDEQRedfKRLGVWGDWDNPYLT 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 151 MDEGLSNAVKEVFVRLHEEGLIYRGKRLVNWDPKLHTAISDLEVE--NKESKgSLWhFRYPLANGAKTADGLD-YLVVAT 227
Cdd:COG0060  157 MDPEYEESIWWALKKLYEKGLLYKGLKPVPWCPRCGTALAEAEVEykDVTSP-SIY-VKFPVKDEKALLLLEDaYLVIWT 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 228 TRPETMLGDTAVAVHPE----------DERY---------------------------QALIGKSVILPLA-----NREI 265
Cdd:COG0060  235 TTPWTLPANLAVAVHPDidyvlvevtgGERLilaealveavlkelgiedyevlatfkgAELEGLRYEHPFYyvvgyDRAH 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 266 PIIADEYVDREFGTGVVKITPAHDFNDYEVGKRHGLPMVNVmtlnadiraeaeiIGTDGKplsdYTAPIPaDYQGLERFA 345
Cdd:COG0060  315 PVILGDYVTTEDGTGIVHTAPGHGEDDFEVGKKYGLPVLNP-------------VDDDGR----FTEEAP-LFAGLFVKD 376

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 346 ARKKIVADFEALGLL---DQIK---PHDlkvpygDRGGVPIEPMLTDQWYVSVKPLAEVATKAVEDgeIQFVPKQYENLY 419
Cdd:COG0060  377 ANPAIIEDLKERGALlarEKIThsyPHC------WRCKTPLIYRATPQWFISMDKLRDRALEAIEK--VNWIPEWGEGRF 448

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 420 FSWMRDIQDWCISRQLWWGHRIPAWYDEQGN-------VY------VARDEAEVRAKHN-----LPADLP-------LKQ 474
Cdd:COG0060  449 GNMLENRPDWCISRQRYWGVPIPIWVCEDCGelhrteeVIgsvaelLEEEGADAWFELDlhrpfLDETLKcpkcggtMRR 528

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 475 DEDVLDTWFSSGLWTFSTLgwpEQTKELKmfHPTDV---------------LITGfdiiffwvarMIMFtmhfikdenGK 539
Cdd:COG0060  529 VPDVLDVWFDSGSMHFAVL---ENREELH--FPADFylegsdqtrgwfyssLLTS----------TALF---------GR 584

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 540 PqvPFKTVYVTGLIRDEQGQKMSKSKGNVLDPIDMIDgislddllekrtgnmmqpqlaekiakatrkefaegivAHGTDA 619
Cdd:COG0060  585 A--PYKNVLTHGFVLDEDGRKMSKSLGNVVDPQEVID-------------------------------------KYGADI 625

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 620 LRFtltALASNGR--DINWDMKRLEGYRNFCNKLWNASRYVLTN-DKLDLSEGDVEFSLA---DRWIESQFNRTVETFRT 693
Cdd:COG0060  626 LRL---WVASSDYwgDLRFSDEILKEVRDVYRRLRNTYRFLLANlDDFDPAEDAVPYEDLpelDRWILSRLNELIKEVTE 702

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 694 ALSQYRFDLVANAIYEFTWDQFCDWYLELTKPIFFKG--TDVQRRGASRTLVNVLEKLLRLIHPVMPFITEEIWQkvkGF 771
Cdd:COG0060  703 AYDNYDFHRAYRALHNFCVEDLSNWYLDISKDRLYTEaaDSLDRRAAQTTLYEVLETLVRLLAPILPFTAEEIWQ---NL 779

                        890       900       910       920
                 ....*....|....*....|....*....|....*....|....*....
gi 493291867 772 VGIEADTIMLQKFPQFDPLAIDETAESQINFIKEVIVAVR----NIRAE 816
Cdd:COG0060  780 PGEAEESVHLADWPEVDEELIDEELEAKWDLVREVRSAVLkaleAARKE 828
PLN02843 PLN02843
isoleucyl-tRNA synthetase
 10-789 2.21e-62

isoleucyl-tRNA synthetase


Pssm-ID: 215452 [Multi-domain]  Cd Length: 974  Bit Score: 229.27  E-value: 2.21e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  10 RFNPSAVEQALYQHWESQGYFKP-SEDINAPSYCIAIPPPNVTGSLHMGHAFQQTLMDTLIRFNRMEGNNTLWQTGTDHA 88
Cdd:PLN02843   2 RANSVTREPEIQKLWEENQVYKRvSDRNNGESFTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  89 GIATQMVVERKIAAEEgktrhdygREAFINKIWDWKA--YSGGTISQQM---RRLGNSIDWDRERFTMDEGLSNAVKEVF 163
Cdd:PLN02843  82 GLPIELKVLQSLDQEA--------RKELTPIKLRAKAakFAKKTVDTQResfKRYGVWGDWENPYLTLDPEYEAAQIEVF 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 164 VRLHEEGLIYRGKRLVNWDPKLHTAISDLEVENKE---SKGSLWHFryPLANGAKTADGL-------DYLVVATTRPETM 233
Cdd:PLN02843 154 GQMFLNGYIYRGRKPVHWSPSSRTALAEAELEYPEghvSKSIYVAF--PVVSPSETSPEEleeflpgLSLAIWTTTPWTM 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 234 LGDTAVAVHP-------------EDERY-----------------------------------------------QALIG 253
Cdd:PLN02843 232 PANAAVAVNDklqysvvevqsfsEDESTsggnkkkrpgnvlkeqqklflivatdlvpaleakwgvklvvlktfpgSDLEG 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 254 KSVILPLANREIPIIAD-EYVDREFGTGVVKITPAHDFNDYEVGKRHGLPMVNVMTLNADIRAEAeiigtdgkplsdyta 332
Cdd:PLN02843 312 CRYIHPLYNRESPVVIGgDYITTESGTGLVHTAPGHGQEDYITGLKYGLPLLSPVDDAGKFTEEA--------------- 376

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 333 pipADYQGLERFAARKKIVADF--EALGLLDQiKPHDLKVPYGDRGGVPIEPMLTDQWYVSVKPLAEVATKAVEdgEIQF 410
Cdd:PLN02843 377 ---GQFSGLSVLGEGNAAVVEAldEAGSLLME-EAYGHKYPYDWRTKKPTIFRATEQWFASVEGFRQAALDAID--KVKW 450

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 411 VPKQYENLYFSWMRDIQDWCISRQLWWGHRIPAWYDEQGNVYVARDEA-----EVRAKHN------------LPADLPLK 473
Cdd:PLN02843 451 IPAQGENRIRAMVSGRSDWCISRQRTWGVPIPVFYHVETKEPLMNEETiahvkSIVAQKGsdawwymdvedlLPEKYRDK 530

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 474 QDE-----DVLDTWFSSGlwtFSTLGWPEQTKELKmfHPTDVLITGFDIIFFWvarmimFTMHFIKDENGKPQVPFKTVY 548
Cdd:PLN02843 531 ASDyekgtDTMDVWFDSG---SSWAGVLGSREGLS--YPADLYLEGSDQHRGW------FQSSLLTSVATKGKAPYKSVL 599

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 549 VTGLIRDEQGQKMSKSKGNVLDPIDMIDGislddllekrtGN--MMQPqlaekiakatrkefaegivAHGTDALRFTLTA 626
Cdd:PLN02843 600 THGFVLDEKGFKMSKSLGNVVDPRLVIEG-----------GKnqKQEP-------------------AYGADVLRLWVAS 649

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 627 LASNGrDINWDMKRL----EGYRnfcnKLWNASRYVLTNdkldLSEGDVEFSLA-------DRWIESQFNRTVETFRTAL 695
Cdd:PLN02843 650 VDYTG-DVLIGPQILkqmsDIYR----KLRGTLRYLLGN----LHDWKPDNAVPyedlpsiDKYALFQLENVVNEIEESY 720

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 696 SQYRFDLVANAIYEFTWDQFCDWYLELTKPIFFKG--TDVQRRGASRTLVNVLEKLLRLIHPVMPFITEEIWQKVK-GFV 772
Cdd:PLN02843 721 DNYQFFKIFQILQRFTIVDLSNFYLDVAKDRLYVGgtTSFTRRSCQTVLAAHLLSLLRAIAPILPHLAEDAWQNLPfQED 800

                        890
                 ....*....|....*..
gi 493291867 773 GIEADTIMLQKFPQFDP 789
Cdd:PLN02843 801 GSAAESVFEAGWPTPNE 817
leuS PRK12300
leucyl-tRNA synthetase; Reviewed
 54-939 2.68e-62

leucyl-tRNA synthetase; Reviewed


Pssm-ID: 237049 [Multi-domain]  Cd Length: 897  Bit Score: 228.21  E-value: 2.68e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  54 LHMGHAFQQTLMDTLIRFNRMEGNNTLW-----QTGTDHAGIAtqmvvERkIAAEEGKTRHDYGR-----EAFINKIWD- 122
Cdd:PRK12300   1 LHVGHGRTYTIGDVIARYKRMRGYNVLFpmafhVTGTPILGIA-----ER-IARGDPETIELYKSlygipEEELEKFKDp 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 123 --WKAYSGGTISQQMRRLGNSIDWDRERFTMDEGLSNAVKEVFVRLHEEGLIYRGKRLVNWDPKLHTAISD---LEVENK 197
Cdd:PRK12300  75 eyIVEYFSEEAKEDMKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNPVGDhdlLDGEEP 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 198 E-SKGSLWHFryplangaKTADGLdYLVVATTRPETMLGDTAVAVHPEDE---------------------RYQ------ 249
Cdd:PRK12300 155 EiVEYTLIKF--------EESEDL-ILPAATLRPETIFGVTNLWVNPDATyvkaevdgekwivskeaaeklSFQdrdvei 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 250 -------ALIGKSVILPLANREIPIIADEYVDREFGTGVVKITPAHDFNDY----EVGKRHGLPMV----NVMTLN---- 310
Cdd:PRK12300 226 ieeikgsELIGKKVKNPVTGKEVPILPADFVDPDNGTGVVMSVPAHAPYDYvalrDLKKNKELLDViepiPLIEVEgyge 305

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 311 ---ADIRAEAEIIGTDGKPLSDYTAPI-------------PADYQGLERFAARKKIVADFEALGLLDQIkpHDLKV-PYG 373
Cdd:PRK12300 306 fpaKEVVEKLGIKSQEDPELEEATKEVyraefhkgvlkenTGEYAGKPVREAREKITKDLIEKGIADIM--YEFSNrPVY 383

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 374 DRGGVPIEP-MLTDQWYV--SVKPLAEVATKAVEdgEIQFVP----KQYENLYFsWMRDiqdWCISRQLWWGHRIPaWYD 446
Cdd:PRK12300 384 CRCGTECVVkVVKDQWFIdySDPEWKELAHKALD--NMEIIPeeyrKEFENTID-WLKD---RACARRRGLGTRLP-WDE 456

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 447 EQ-------GNVY-----VARdeaEVRaKHNLPADlplKQDEDVLDTWF----SSGLWTFSTLGWPEQTKELKM----FH 506
Cdd:PRK12300 457 EWiieslsdSTIYmayytIAH---KIR-EYGIKPE---QLTPEFFDYVFlgkgDPEEVSKKTGIPKEILEEMREeflyWY 529

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 507 PTDVLITGFDII-----FFwvarmiMFTMHFIKDENGKPqvpfKTVYVTGLIRDEqGQKMSKSKGNVldpidmidgISLD 581
Cdd:PRK12300 530 PVDWRHSGKDLIpnhltFF------IFNHVAIFPEEKWP----RGIVVNGFVLLE-GKKMSKSKGNV---------IPLR 589

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 582 DLLEKrtgnmmqpqlaekiakatrkefaegivaHGTDALRFTLTALASNGRDINWDMKRLEGYRNFCNKLWNasryvlTN 661
Cdd:PRK12300 590 KAIEE----------------------------YGADVVRLYLTSSAELLQDADWREKEVESVRRQLERFYE------LA 635

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 662 DKLDLSEGDVEFSLADRWIESQFNRTVETFRTALSQYRF-DLVANAIYEFTWDqfCDWYLELTKpiffkgtdvqrRGASR 740
Cdd:PRK12300 636 KELIEIGGEEELRFIDKWLLSRLNRIIKETTEAMESFQTrDAVQEAFYELLND--LRWYLRRVG-----------EANNK 702

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 741 TLVNVLEKLLRLIHPVMPFITEEIWQKV--KGFVGIEadtimlqKFPQFDPLAIDETAESQINFIKEVIVAVRNIRAESN 818
Cdd:PRK12300 703 VLREVLEIWIRLLAPFTPHLAEELWHKLggEGFVSLE-------KWPEPDESKIDEEAELAEEYVKRLIEDIREILKVAK 775

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 819 IAPSKgldliarnfsadeVSILNANEvllksmAKLDSVKVLENGENAPLSVAKLVANGEilipMAGFINKEAELA-RLTK 897
Cdd:PRK12300 776 IKPKK-------------VYIYVAPD------WKYEVLEIAAENGDVKEAIKELMKDEE----LRKHGKEVAKLAqKIVK 832

                        970       980       990      1000
                 ....*....|....*....|....*....|....*....|..
gi 493291867 898 EMDKLKGEVARIEGKLSNEafvakapEQVIakerEKMQEYLS 939
Cdd:PRK12300 833 EVLKLDKEVRKLILKNIDE-------EEVL----EEAKDFLE 863
Anticodon_Ia_Val cd07962
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ...
 636-767 5.92e-62

Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.


Pssm-ID: 153416 [Multi-domain]  Cd Length: 135  Bit Score: 206.25  E-value: 5.92e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 636 WDMKRLEGYRNFCNKLWNASRYVLTN--DKLDLSEGDVEFSLADRWIESQFNRTVETFRTALSQYRFDLVANAIYEFTWD 713
Cdd:cd07962    1 FDEKRVEGGRNFCNKLWNAARFVLMNleDDDEPEEDPESLSLADRWILSRLNKTVEEVTEALENYRFSEAATALYEFFWN 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 493291867 714 QFCDWYLELTKPIFFKGTDVQRRGASRTLVNVLEKLLRLIHPVMPFITEEIWQK 767
Cdd:cd07962   81 DFCDWYLELVKPRLYGEDEEEKKAARATLYYVLETILRLLHPFMPFITEELWQR 134
Ile_Leu_Val_MetRS_core cd00668
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ...
 41-636 1.63e-56

catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.


Pssm-ID: 185674 [Multi-domain]  Cd Length: 312  Bit Score: 197.64  E-value: 1.63e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  41 YCIAIPPPNVTGSLHMGHAFQQTLMDTLIRFNRMEGNNTLWQTGTDHAGIATQMVVERKiAAEEGKTRHdygREAFINKI 120
Cdd:cd00668    2 FYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERK-GGRKKKTIW---IEEFREDP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 121 WDWKAYSGGTISQQMRRLGNSIDWDRERFTMDEGLSNAVKEVFVRLHEEGLIYRGKRLVNWDPKlhtaisdlevenkesk 200
Cdd:cd00668   78 KEFVEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGTHPVRITEQ---------------- 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 201 gslWHFRYPlangaktadgldylvvattrpetmlgdtavavhPEDERYQAligksvilplANREIPIiadeyvdrefgtg 280
Cdd:cd00668  142 ---WFFDMP---------------------------------KFKEKLLK----------ALRRGKI------------- 162

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 281 vvkitpahdfndyevgkrhglpmvnvmtlnadiraeaeiigtdgkplsdytapipadyqglerfaarkkivadfealgll 360
Cdd:cd00668      --------------------------------------------------------------------------------

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 361 dqikphdlkvpygdrggvpiepmltdqwyvsvkplaevatkavedgeiqfVPKQYENLYFSWMRDIQDWCISRQLWWGHR 440
Cdd:cd00668  163 --------------------------------------------------VPEHVKNRMEAWLESLLDWAISRQRYWGTP 192

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 441 IPawydeqgnvyvardeaevrakhnlpadlplkqdEDVLDTWFSSGLWTFSTLGWPEQTKELKMFHPTDVLITGFDIIFF 520
Cdd:cd00668  193 LP---------------------------------EDVFDVWFDSGIGPLGSLGYPEEKEWFKDSYPADWHLIGKDILRG 239

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 521 WVARMIMFTMHFikdeNGkpQVPFKTVYVTGLIRDEQGQKMSKSKGNVLDPIDMIdgislddllekrtgnmmqpqlaeki 600
Cdd:cd00668  240 WANFWITMLVAL----FG--EIPPKNLLVHGFVLDEGGQKMSKSKGNVIDPSDVV------------------------- 288

                        570       580       590
                 ....*....|....*....|....*....|....*.
gi 493291867 601 akatrKEFaegivahGTDALRFTLTALASNGRDINW 636
Cdd:cd00668  289 -----EKY-------GADALRYYLTSLAPYGDDIRL 312
LeuS COG0495
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ...
 7-801 7.94e-53

Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 440261 [Multi-domain]  Cd Length: 826  Bit Score: 199.12  E-value: 7.94e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867   7 MEDRFNPSAVEQALYQHWESQGYFKPSEDINAPSY--CIAIPPPnvTGSLHMGHAFQQTLMDTLIRFNRMEGNNTL---- 80
Cdd:COG0495    1 MQERYNPKEIEKKWQKYWEENGTFKADEDSSKPKYyvLDMFPYP--SGRLHMGHVRNYTIGDVVARYKRMQGYNVLhpmg 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  81 W------------QTGTdHAGIATqmvvERKIAaeegktrhdygreafinkiwdwkaysggTISQQMRRLGNSIDWDRER 148
Cdd:COG0495   79 WdafglpaenaaiKNGV-HPAEWT----YENIA----------------------------NMRRQLKRLGLSYDWSREI 125

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 149 FTMDEglsnavkE-------VFVRLHEEGLIYRGKRLVNWDPKLHTAI------------SDLEVENKE----------- 198
Cdd:COG0495  126 ATCDP-------EyykwtqwIFLQLYEKGLAYRKEAPVNWCPVDQTVLaneqvidgrcwrCGAPVEKKElpqwflkitdy 198

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 199 ----------------------------SKGSlwHFRYPLANGAKTadgldyLVVATTRPETMLGDTAVAV---HP---- 243
Cdd:COG0495  199 adellddldkldgwpekvktmqrnwigrSEGA--EVDFPVEGSDEK------ITVFTTRPDTLFGATFMVLapeHPlvke 270

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 244 --EDERYQAL--------------------------IGKSVILPLANREIPI-IADeYVDREFGTGVVKITPAHDFNDYE 294
Cdd:COG0495  271 laTPEQNAAVaafieeakkkseiertsetkektgvfTGLYAINPLTGEKIPIwIAD-YVLMDYGTGAVMAVPAHDQRDFE 349

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 295 VGKRHGLPMVNVmtlnadiraeaeIIGTDGKPLSDYTAPIPAD--------YQGLERFAARKKIVADFEALGLldqikph 366
Cdd:COG0495  350 FAKKYGLPIKQV------------IAPEDGDDPDILEEAYTGDgvlinsgeFDGLDSEEAKEAIIEWLEEKGL------- 410

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 367 dlkvpygdrggvpiepmltdqwyvsvkplaevATKAVedgeiqfvpkQYenlyfswmRdIQDWCISRQLWWGHRIPAWYD 446
Cdd:COG0495  411 --------------------------------GKRKV----------NY--------R-LRDWLISRQRYWGEPIPIIHC 439

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 447 EQGNVyVARDEAE--VRakhnLPADL--------PLKQDE------------------DVLDTWF-SSglWTFstLGWPE 497
Cdd:COG0495  440 EDCGV-VPVPEDQlpVE----LPEDVdfdptggsPLARAPewvnvtcpkcggparretDTMDTFVdSS--WYY--LRYTD 510

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 498 QTKELKMFH--------PTDVLITGfdiI-----------FFWvarMIMFTMHFIK-DEngkpqvPFKTV----YVTGLI 553
Cdd:COG0495  511 PHNDEAPFDpeaanywlPVDQYIGG---IehailhllyarFFT---KVLRDLGLVSfDE------PFKRLltqgMVLEVG 578

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 554 RD----EQGQKMSKSKGNVLDPIDMIDgislddllekrtgnmmqpqlaekiakatrkefaegivAHGTDALR-FTLTAla 628
Cdd:COG0495  579 KDgvviGGIEKMSKSKGNVVDPDEIIE-------------------------------------KYGADTLRlFEMFA-- 619

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 629 snG---RDINWDMKRLEGYRNFCNKLWNasryvLTNDKLDLSEGDV-EFSLADRWIESQFNRTVETFRTALSQYRFDLVA 704
Cdd:COG0495  620 --GppeRDLEWSDSGVEGAYRFLNRVWR-----LVVDEAEALKLDVaDLSEADKELRRALHKTIKKVTEDIERLRFNTAI 692

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 705 NAIYEFTwdqfcdwyLELTKpifFKGTDVQRRGASRTlvnVLEKLLRLIHPVMPFITEEIWQKVKGfvgieADTIMLQKF 784
Cdd:COG0495  693 AALMELV--------NALYK---AKDSGEADRAVLRE---ALETLVLLLAPFAPHIAEELWERLGH-----EGSVADAPW 753

                        970       980
                 ....*....|....*....|
gi 493291867 785 PQFDP-LAIDETAE--SQIN 801
Cdd:COG0495  754 PEADEaALVEDEVTivVQVN 773
leuS_bact TIGR00396
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ...
 11-820 3.20e-52

leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273057 [Multi-domain]  Cd Length: 842  Bit Score: 197.28  E-value: 3.20e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867   11 FNPSAVEQALYQHWESQGYFKPSEDINAPSYCIAIPPPNVTGSLHMGHAFQQTLMDTLIRFNRMEGNNTLWQTGTDHAGI 90
Cdd:TIGR00396   1 YNHIEIEEKWQQKWDENKTFKVTDDSSKPKYYILSMFPYPSGALHMGHVRNYTITDVLSRYYRMKGYNVLHPIGWDAFGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867   91 -ATQMVVERKIAAeegktrhdygreafinKIWDWK--AYsggtISQQMRRLGNSIDWDRERFTMDEGLSNAVKEVFVRLH 167
Cdd:TIGR00396  81 pAENAAIKRGIHP----------------AKWTYEniAN----MKKQLQALGFSYDWDREIATCDPEYYKWTQWIFLELF 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  168 EEGLIYRGKRLVNWDPKLHTAI-------------SDLEVENKE------------------------------------ 198
Cdd:TIGR00396 141 EKGLAYVKEADVNWCPNDGTVLaneqvdsdgrswrGDTPVEKKElkqwflkitayaeellndleeldhwpesvkemqrnw 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  199 ---SKGSLWHFryplangaKTADGLDYLVVATTRPETMLGDTAVAVHPE--------------DERYQALIGKSV----- 256
Cdd:TIGR00396 221 igkSEGVEITF--------KIADHDEKITVFTTRPDTIFGVTYLALAPEhplvekaaennpkvAAFIKKILNKTVaertk 292

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  257 --------------ILPLANREIPIIADEYVDREFGTGVVKITPAHDFNDYEVGKRHGLPMVNVMTLNADIRAEAEIIGT 322
Cdd:TIGR00396 293 atkekkgvdtgikaIHPLTGEKIPIWVANYVLMEYGTGAVMGVPAHDERDFEFAQKYGLPIKPVIDPAEKDLSLTAAYTE 372

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  323 DGKPLSdytapiPADYQGLERFAARKKIVADFEALGLldqikpHDLKVPYgdrggvpiepmltdqwyvsvkplaevatka 402
Cdd:TIGR00396 373 DGVLVN------SGEFNGLNSSEARNAIIDMLEKEGK------GKRKVNY------------------------------ 410

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  403 vedgeiqfvpkqyenlyfswmrDIQDWCISRQLWWGHRIPAWYDEQGNVyVARDEAEVRAKhnLPADL--------PLKQ 474
Cdd:TIGR00396 411 ----------------------RLRDWGFSRQRYWGEPIPIIHCEDGGV-VPVPEEDLPVI--LPEDVvydgdggsPLSR 465

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  475 DE------------------DVLDTWFSSGlWTFSTLGWPEQT------KELKMFHPTDVLITGFD--IIFFWVARmimF 528
Cdd:TIGR00396 466 IPewvnvtcpscgkpalretDTMDTFAGSS-WYYLRYLDPKNTdgpfdkEKAEYWLPVDLYIGGIEhaILHLLYAR---F 541

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  529 TMHFIKDENGKP-QVPFKTVY----VTGLIRDEQGQ---------------------------KMSKSKGNVLDPIDMID 576
Cdd:TIGR00396 542 FHKFLRDIGYVNtKEPFKKLInqgmVLGFYYPPNGKvpadvlterdekgkdkaggelvyvgyeKMSKSKGNGIDPQEIVE 621

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  577 gislddllekrtgnmmqpqlaekiakatrkefaegivAHGTDALRFTLTALASNGRDINWDMKRLEGYRNFCNKLWN-AS 655
Cdd:TIGR00396 622 -------------------------------------SYGADALRLFIMFMGPIAASLEWNESGLEGARRFLDRVWNlVY 664

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  656 RYVLTNDKLDLSEGDVEfsLADRWIESQFNRTV----------ETFRTALSQYRfdLVANAIYEFTWDqfcdwyleltkp 725
Cdd:TIGR00396 665 EITGELDAASLTVTALE--EAQKELRRDVHKFLkkvtedlekrESFNTAISAMM--ELLNKLYKAKKE------------ 728

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  726 iffkgtdvqrrgasRTLVNVLEKLLRLIHPVMPFITEEIWQKvkgfVGIEADTIMLQKFPQFDPLAIDEtaesqinFIKE 805
Cdd:TIGR00396 729 --------------ALMLEYLKGFVTVLSPFAPHLAEELWEK----LGSEPFIIDNAKWPVVDETALVE-------DKTL 783

                         970
                  ....*....|....*.
gi 493291867  806 VIVAVR-NIRAESNIA 820
Cdd:TIGR00396 784 IVVQVNgKFRAKITVP 799
PLN02882 PLN02882
aminoacyl-tRNA ligase
 17-819 9.58e-46

aminoacyl-tRNA ligase


Pssm-ID: 215477 [Multi-domain]  Cd Length: 1159  Bit Score: 178.77  E-value: 9.58e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867   17 EQALYQHWESQGYFKP--SEDINAPSYCIAIPPPNVTGSLHMGHAFQQTLMDTLIRFNRMEGNNTLWQTGTDHAGIAtqm 94
Cdd:PLN02882   14 EEKILSLWSEIDAFKTqlKRTEGLPEYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGWDCHGLP--- 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867   95 vVERKIAAEEGKTRHDYGREAFINKiwdwkaYSGGTISQQMR----------RLGNSIDWDRERFTMDEGLSNAVKEVFV 164
Cdd:PLN02882   91 -VEYEIDKKLGIKRRDDVLKMGIDK------YNEECRSIVTRyskewektvtRTGRWIDFENDYKTMDPKFMESVWWVFK 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  165 RLHEEGLIYRGKRLVNWDPKLHTAISDLEV--ENKESKGSLWHFRYPLANGAKTADgldyLVVATTRPETMLGDTAVAVH 242
Cdd:PLN02882  164 QLFEKGLVYKGFKVMPYSTACKTPLSNFEAglNYKDVSDPAVMVSFPIVGDPDNAS----FVAWTTTPWTLPSNLALCVN 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  243 PE-----------------------------------------DERYQAL---IGKSVI-----------LPLANREIPI 267
Cdd:PLN02882  240 PNftyvkvrnkytgkvyivaesrlsalptakpkskkgskpenaAEGYEVLakvPGSSLVgkkyeplfdyfSEFSDTAFRV 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  268 IADEYVDREFGTGVVKITPAHDFNDYEVGKRHGlpmvnvmtlnadiraeaeIIGTDGK---PLSD---YTAPIPaDYQGL 341
Cdd:PLN02882  320 VADDYVTDDSGTGVVHCAPAFGEDDYRVCLANG------------------IIEKGGNlpvPVDDdgcFTEKVT-DFSGR 380

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  342 ERFAARKKIVADFEALGLLDQIKPHDLKVPYGDRGGVPIEPMLTDQWYVSVKplaEVATKAVEDGE-IQFVPKQY-ENLY 419
Cdd:PLN02882  381 YVKDADKDIIAAIKAKGRLVKSGSITHSYPFCWRSDTPLIYRAVPSWFVKVE---EIKDRLLENNKqTYWVPDYVkEKRF 457

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  420 FSWMRDIQDWCISRQLWWGHRIPAWYDEQGN---VYVARDEAE----VRA----KHNL----------PADLPLKQDEDV 478
Cdd:PLN02882  458 HNWLENARDWAVSRSRFWGTPLPIWISDDGEevvVIGSIAELEklsgVKVtdlhRHFIdhitipssrgPEFGVLRRVDDV 537

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  479 LDTWFSSGLWTFSTLGWPEQTKEL--KMFhPTDVLITGFDIIFFWV-ARMIMFTMHFikdenGKPQvpFKTVYVTGLIRD 555
Cdd:PLN02882  538 FDCWFESGSMPYAYIHYPFENKELfeKNF-PADFVAEGLDQTRGWFyTLMVLSTALF-----DKPA--FKNLICNGLVLA 609

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  556 EQGQKMSKSKGNVLDPIDMIDgislddllekrtgnmmqpqlaekiakatrkefaegivAHGTDALRFTLtalasngrdIN 635
Cdd:PLN02882  610 EDGKKMSKSLKNYPDPNEVID-------------------------------------KYGADALRLYL---------IN 643

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  636 WDMKRLEGYRnFCNK------------LWNASRYVLTNDKLDLSEGDVEFS------------LADRWIESQFNRTVETF 691
Cdd:PLN02882  644 SPVVRAEPLR-FKEEgvfgvvkdvflpWYNAYRFLVQNAKRLEVEGGAPFVpldlaklqnsanVLDRWINSATQSLVKFV 722

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  692 RTALSQYRFDLVANAIYEFTwDQFCDWYLELTKPiFFKGT--DVQRRGASRTLVNVLEKLLRLIHPVMPFITEEIWQKVK 769
Cdd:PLN02882  723 REEMGAYRLYTVVPYLVKFI-DNLTNIYVRFNRK-RLKGRtgEEDCRTALSTLYNVLLTSCKVMAPFTPFFTEVLYQNLR 800

                         890       900       910       920       930
                  ....*....|....*....|....*....|....*....|....*....|
gi 493291867  770 GFVGIEADTIMLQKFPQFDPLAIDETAESQINFIKEVIVAVRNIRAESNI 819
Cdd:PLN02882  801 KVLPGSEESIHYCSFPQVDEGELDERIEQSVSRMQTVIELARNIRERHNK 850
Anticodon_1 pfam08264
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ...
 677-828 4.27e-44

Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.


Pssm-ID: 400523 [Multi-domain]  Cd Length: 141  Bit Score: 156.02  E-value: 4.27e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  677 DRWIESQFNRTVETFRTALSQYRFDLVANAIYEFTWDQFCDWYLELTKPIFFKGTDVQRrgASRTLVNVLEKLLRLIHPV 756
Cdd:pfam08264   1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWNDLSDWYLELIKDRLYGEEPDSR--AQTTLYEVLETLLRLLAPF 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 493291867  757 MPFITEEIWQKvkgfvgieaDTIMLQKFPQfDPLAIDETAESQINFIKEVIVAVRNIRAESNIAPSKGLDLI 828
Cdd:pfam08264  79 MPFITEELWQK---------ESIHLAPWPE-DAELEEAELEEAFELRQEIVQAIRKLRSELKIKKSLPLEVV 140
IleRS_core cd00818
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ...
 39-576 7.50e-34

catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 173909 [Multi-domain]  Cd Length: 338  Bit Score: 133.13  E-value: 7.50e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  39 PSYCIAIPPPNVTGSLHMGHAFQQTLMDTLIRFNRMEGNNTLWQTGTDHAGIATQMVVERKIAAEEGKTRHDYGREAFIN 118
Cdd:cd00818    1 PEFVFHDGPPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELGISGKKDIEKMGIAEFNA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 119 K--------IWDWKAysggtisqQMRRLGNSIDWDRERFTMDEGLSNAVKEVFVRLHEEGLIYRGKRLVNWdpklhtais 190
Cdd:cd00818   81 KcrefalryVDEQEE--------QFQRLGVWVDWENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVPW--------- 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 191 dlevenkeskgslwhfryplangaktadgldylvvattrpetmlgdtavavhpederyqaligksvilplanreiPIIad 270
Cdd:cd00818  144 ---------------------------------------------------------------------------PLI-- 146

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 271 eyvdrefgtgvvkitpahdfndyevgkrhglpmvnvmtlnadIRAeaeiigtdgkplsdytapipadyqglerfaarkki 350
Cdd:cd00818  147 ------------------------------------------YRA----------------------------------- 149

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 351 vadfealglldqikphdlkvpygdrggvpiepmlTDQWYVSVKPLAEVATKAVEdgEIQFVPKQYENLYFSWMRDIQDWC 430
Cdd:cd00818  150 ----------------------------------TPQWFIRVTKIKDRLLEAND--KVNWIPEWVKNRFGNWLENRRDWC 193

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 431 ISRQLWWGHRIPAWYDEQGNVYVARDEaevrakhnlpadlplkqdEDVLDTWFSSGLWTFSTLGWPEQTKELKMFHPTDV 510
Cdd:cd00818  194 ISRQRYWGTPIPVWYCEDCGEVLVRRV------------------PDVLDVWFDSGSMPYAQLHYPFENEDFEELFPADF 255

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 493291867 511 LITGFDIIFFWV-ARMIMFTMHFikdenGKPqvPFKTVYVTGLIRDEQGQKMSKSKGNVLDPIDMID 576
Cdd:cd00818  256 ILEGSDQTRGWFySLLLLSTALF-----GKA--PYKNVIVHGFVLDEDGRKMSKSLGNYVDPQEVVD 315
Anticodon_Ia_Ile_ABEc cd07961
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ...
 645-811 1.44e-30

Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.


Pssm-ID: 153415 [Multi-domain]  Cd Length: 183  Bit Score: 118.81  E-value: 1.44e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 645 RNFCNKLWNASRYVLTN---DKLDLSEGDVEFSLA---DRWIESQFNRTVETFRTALSQYRFDLVANAIYEFtWDQFCDW 718
Cdd:cd07961   11 RKVLLPLWNAYRFFVTYanlDGFDPGKDDDAVASLnvlDRWILSRLNSLIKEVTEEMEAYDLYTAVRALLEF-IDELTNW 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 719 YLELTKPIFFKGTDVQ-RRGASRTLVNVLEKLLRLIHPVMPFITEEIWQKVKGFVGIEADTIMLQKFPQFDPLAIDETAE 797
Cdd:cd07961   90 YIRRNRKRFWGEEGDDdKLAAYATLYEVLLTLSRLMAPFTPFITEEIYQNLRRELGDAPESVHLLDWPEVDESLIDEELE 169

                        170
                 ....*....|....
gi 493291867 798 SQINFIKEVIVAVR 811
Cdd:cd07961  170 EAMELVREIVELGR 183
PTZ00427 PTZ00427
isoleucine-tRNA ligase, putative; Provisional
 12-853 2.61e-30

isoleucine-tRNA ligase, putative; Provisional


Pssm-ID: 173617 [Multi-domain]  Cd Length: 1205  Bit Score: 129.70  E-value: 2.61e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867   12 NPSAVE--QALYQHWESQGYFKPSEDI--NAPSYCIAIPPPNVTGSLHMGHAFQQTLMDTLIRFNRMEGNNTLWQTGTDH 87
Cdd:PTZ00427   71 NPNIVEeeEKVLKYWKSIDAFNTSNKLakNKKAYIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFGWDC 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867   88 AGIATQMVVERKIAAEEGKTRHDYGREAFINKIWDWKAYSGGTISQQMRRLGNSIDWDRERFTMDEGLSNAVKEVFVRLH 167
Cdd:PTZ00427  151 HGLPIEYEIEKENNINKKEDILKMGIDVYNEKCRGIVLKYSNEWVKTVERIGRWIDFKNDYKTMDKTFMESVWWVFSELY 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  168 EEGLIYRGKRLVNWDPKLHTAISDLE-------------------------VEN----KESKGSLWHFRYPLAN------ 212
Cdd:PTZ00427  231 KNNYVYKSFKVMPYSCKCNTPISNFElnlnykdtpdpsiiisfvlcsdfpkVEEecniEEDKQLLGEKYSVLYNnkrens 310

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  213 ---GAKTADGLDY-----LVVATTRPETMLGDTAVAV----------HPEDERY-------------------------Q 249
Cdd:PTZ00427  311 nngNNNSTNNVCYaqhseILAWTTTPWTLPSNLALCVnehftylrihHVKSNRVvivgecrlewimkelkwnvedlkivN 390

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  250 ALIGKSV----ILPLAN----------REIPIIADEYVDREFGTGVVKITPAHDFNDYEVGKRHGL--PMVNV----MTL 309
Cdd:PTZ00427  391 RFKGKELkglrYKPLFTnfyekynfkeRAYKILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKNGVidPEKNIfidpLDA 470

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  310 NADIRAEAEIIgtDGKPLSDYTAPIPADYQGLERFAARKKIVADFealglldqikphdlkvPYGDRGGVPIEPMLTDQWY 389
Cdd:PTZ00427  471 NGYFTNEVEEV--QNLYIKEADNVIKKKLKNENRLLSNNTIVHSY----------------PFCWRSDTPLIYRAIPAWF 532

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  390 VSVkplAEVATKAVEDGEIQF-VPKQY-ENLYFSWMRDIQDWCISRQLWWGHRIPAWYDEQGNVYVARDE---------- 457
Cdd:PTZ00427  533 IRV---SNSTNELVKNNETTYwIPAHIkEKKFHNWIKDAKDWCISRNRYWGTPIPIWADEKMETVICVESikhleelsgv 609

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  458 AEVRAKH-----NLPADLP-------LKQDEDVLDTWFSSGLWTFSTLGWPEQTkELKMFH---PTDVLITGFDIIFFWV 522
Cdd:PTZ00427  610 KNINDLHrhfidHIEIKNPkgktypkLKRIPEVFDCWFESGSMPYAKVHYPFST-EKEDFHkifPADFIAEGLDQTRGWF 688

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  523 ARMIMF-TMHFIKdengkpqVPFKTVYVTGLIRDEQGQKMSKSKGNVLDPIDMIDGISLDDLlekrtgnmmQPQLAEKIA 601
Cdd:PTZ00427  689 YTLLVIsTLLFDK-------APFKNLICNGLVLASDGKKMSKRLKNYPDPLYILDKYGADSL---------RLYLINSVA 752

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  602 -KATRKEFAEGIVAHGTDAlrFTLTALASngrdinwdmkrlegYRNFCNKLwnaSRYVLTNDKLDLSEGDVEF---SLAD 677
Cdd:PTZ00427  753 vRAENLKFQEKGVNEVVKS--FILPFYHS--------------FRFFSQEV---TRYECLNKKQFLFNTDYIYkndNIMD 813

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  678 RWIESQFNRTVETFRTALSQYRFDLVANAIYEFTwDQFCDWYLELTKpiffkgtDVQR--RGASRTL--VNVLEKLLRL- 752
Cdd:PTZ00427  814 QWIFSSVQSLTKSVHTEMKAYKLYNVLPKLLQFI-ENLTNWYIRLNR-------DRMRgsLGEENCLqsLCTTYRTLHLf 885

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  753 ---IHPVMPFITEEIWQKVKGFV---------------------GIEADTIMLQKFPQFDP-LAIDETAESQINFIKEVI 807
Cdd:PTZ00427  886 tvlMAPFTPFITEYIYQQLRRVKstnehnennetgntkegdlnrGVIHKSVHFIMLPQVDEkYIIDYEIIELIEKMKDVI 965

                         970       980       990      1000
                  ....*....|....*....|....*....|....*....|....*.
gi 493291867  808 VAVRNIRAESNIAPSKGLdliarnfsaDEVSILNANEVLLKSMAKL 853
Cdd:PTZ00427  966 LLGRVLRERRKVASKKPL---------KSITILHPNESYFKNFDQI 1002
PLN02563 PLN02563
aminoacyl-tRNA ligase
 16-789 1.64e-27

aminoacyl-tRNA ligase


Pssm-ID: 178177 [Multi-domain]  Cd Length: 963  Bit Score: 120.31  E-value: 1.64e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  16 VEQALYQHWESQGYFKPSEDINA--PSYCI--AIPPPNVTGsLHMGHAFQQTLMDTLIRFNRMEGNNTLWQTGTDHAGI- 90
Cdd:PLN02563  85 IEPKWQRYWEENRTFRTPDDVDTskPKFYVldMFPYPSGAG-LHVGHPEGYTATDILARYKRMQGYNVLHPMGWDAFGLp 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  91 ATQMVVERKIAAEEGKTRHdygreafINKIwdwkaysggtiSQQMRRLGNSIDWDRERFTMDEGLSNAVKEVFVRLHEEG 170
Cdd:PLN02563 164 AEQYAIETGTHPKITTLKN-------IARF-----------RSQLKSLGFSYDWDREISTTEPEYYKWTQWIFLQLLKRG 225

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 171 LIYRGKRLVNWDPKLHTAISDLEVENKES-KGSLWHFRYPLANGAK--TA---------DGLDY---------------- 222
Cdd:PLN02563 226 LAYQAEVPVNWCPALGTVLANEEVVDGLSeRGGHPVIRKPMRQWMLkiTAyadrlledlDDLDWpesikemqrnwigrse 305

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 223 -------------------LVVATTRPETMLGDTAVAVHPE---------DERYQAL----------------------- 251
Cdd:PLN02563 306 gaeldfsvldgegkerdekITVYTTRPDTLFGATYLVVAPEhpllsslttAEQKEAVeeyvdaasrksdlertelqkekt 385

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 252 ---IGKSVILPLANREIPIIADEYVDREFGTGVVKITPAHDFNDYEVGKRHGLPMVNVMTLNADIRAEAEIIGT-DGKPL 327
Cdd:PLN02563 386 gvfTGSYAINPATGEAIPIWVADYVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKWVVKPADGNEDDAEKAYTgEGVIV 465

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 328 SDYTAPIpaDYQGLERFAARKKIVADFEALGLLDQikphdlKVPYGDRggvpiepmltdqwyvsvkplaevatkavedge 407
Cdd:PLN02563 466 NSSSSGL--DINGLSSKEAAKKVIEWLEETGNGKK------KVNYKLR-------------------------------- 505

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 408 iqfvpkqyenlyfswmrdiqDWCISRQLWWGHRIPAWYDEQGNVYVARDEAEvrakhnLPADLP--------------LK 473
Cdd:PLN02563 506 --------------------DWLFARQRYWGEPIPVVFLEDSGEPVPVPESD------LPLTLPelddftptgtgeppLA 559

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 474 QDEDVLDTWF-SSGLW----TFSTLGW------------PEQTKEL------KMFHPTDVLITGFD--IIFFWVARM--- 525
Cdd:PLN02563 560 KAVSWVNTVDpSSGKParreTNTMPQWagscwyylrfmdPKNSNALvdkekeKYWMPVDLYVGGAEhaVLHLLYARFwhk 639

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 526 IMFTMHFIKDENgkpqvPFKTVYVTGLI---------RDEQGQKMSKSKGNVLDPIDMIDgISLDDLLEKRTGNMMQ--P 594
Cdd:PLN02563 640 VLYDIGVVSTKE-----PFQCLVNQGMIlgeveytafKDSDGEYVSADTADRLGELQQEK-IPEEKVIKSGDSFVLKddP 713

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 595 QLaEKIAKATRKEFAEGIV--------AHGTDALRFtLTALASNGRDIN-WDMKRLEGYRNFCNKLWnasRYVLTNDKLD 665
Cdd:PLN02563 714 SI-RLIARAHKMSKSRGNVvnpddvvsEYGADSLRL-YEMFMGPLRDSKtWSTSGVEGVHRFLGRTW---RLVVGAPLPD 788

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 666 LSEGDVEFSLADRWIESQ---FNRTVETFRTALSQYRFDLVANAIYEFT-----WDqfcdwylelTKPiffkgtdvqrrg 737
Cdd:PLN02563 789 GSFRDGTVVTDEEPSLEQlrlLHKCIAKVTEEIESTRFNTAISAMMEFTnaaykWD---------KVP------------ 847

                        890       900       910       920       930
                 ....*....|....*....|....*....|....*....|....*....|..
gi 493291867 738 asrtlVNVLEKLLRLIHPVMPFITEEIWQKVKgfvgiEADTIMLQKFPQFDP 789
Cdd:PLN02563 848 -----REAIEPFVLLLSPYAPHLAEELWFRLG-----HSNSLAYEPWPEANP 889
PRK11893 PRK11893
methionyl-tRNA synthetase; Reviewed
 41-766 1.27e-19

methionyl-tRNA synthetase; Reviewed


Pssm-ID: 237012 [Multi-domain]  Cd Length: 511  Bit Score: 93.41  E-value: 1.27e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  41 YCIAIPPPNVTGSLHMGHAFQQTLMDTLIRFNRMEGNNTLWQTGTD-HagiatQMVVERKiAAEEGKTRHDYGREafink 119
Cdd:PRK11893   3 FYITTPIYYPNGKPHIGHAYTTLAADVLARFKRLRGYDVFFLTGTDeH-----GQKIQRK-AEEAGISPQELADR----- 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 120 iwdwkaysggtISQQMRRLGNSIDWDRERF--TMDEGLSNAVKEVFVRLHEEGLIYRGKrlvnwdpklhtaisdlevenk 197
Cdd:PRK11893  72 -----------NSAAFKRLWEALNISYDDFirTTDPRHKEAVQEIFQRLLANGDIYLGK--------------------- 119

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 198 eSKGslWhfryplangaktadgldYLVvattRPETMLGDTAVAvhpEDERYQALIGKSVilplanreipiiadEYVDRE- 276
Cdd:PRK11893 120 -YEG--W-----------------YCV----RCEEFYTESELI---EDGYRCPPTGAPV--------------EWVEEEs 158

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 277 -FgtgvvkitpahdFNdyevgkrhglpmvnvmtlnadiraeaeiigtdgkpLSDYTAPIPADYQGLERF---AARKKIVA 352
Cdd:PRK11893 159 yF------------FR-----------------------------------LSKYQDKLLELYEANPDFiqpASRRNEVI 191

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 353 DFEALGLldqikphdlkvpygdrggvpiepmltdqwyvsvkplaevatkavedgeiqfvpkqyenlyfswmrdiQDWCIS 432
Cdd:PRK11893 192 SFVKSGL-------------------------------------------------------------------KDLSIS 204

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 433 RQ-LWWGhripawydeqgnvyvardeaevrakhnlpadLPLKQDED-VLDTWFSSGLWTFSTLGWPEQTKELKM----FH 506
Cdd:PRK11893 205 RTnFDWG-------------------------------IPVPGDPKhVIYVWFDALTNYLTALGYPDDEELLAElfnkYW 253

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 507 PTDVLITGFDIIFF----WVArmimFTMHfikdeNGKPQvpFKTVYVTGLIRDEqGQKMSKSKGNVLDPIDMIDgisldd 582
Cdd:PRK11893 254 PADVHLIGKDILRFhavyWPA----FLMA-----AGLPL--PKRVFAHGFLTLD-GEKMSKSLGNVIDPFDLVD------ 315

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 583 llekrtgnmmqpqlaekiakatrkEFaegivahGTDALRFTLTALASNGRDINWDMKRLEGYRN--FCNKLWN-ASRYV- 658
Cdd:PRK11893 316 ------------------------EY-------GVDAVRYFLLREIPFGQDGDFSREAFINRINadLANDLGNlAQRTLs 364

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 659 -LTNDKLDLSEGDVEFSLADRWIESQFNRTVETFRTALSQYRFDLVANAIYEFTwdQFCDWYLELTKPIFFKGTDVQRrg 737
Cdd:PRK11893 365 mIAKNFDGKVPEPGALTEADEALLEAAAALLERVRAAMDNLAFDKALEAILALV--RAANKYIDEQAPWSLAKTDPER-- 440

                        730       740       750
                 ....*....|....*....|....*....|....*.
gi 493291867 738 asrtLVNVLEKLLR-------LIHPVMPFITEEIWQ 766
Cdd:PRK11893 441 ----LATVLYTLLEvlrgiavLLQPVMPELAAKILD 472
Anticodon_Ia_Ile_BEm cd07960
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ...
 638-806 2.58e-18

Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.


Pssm-ID: 153414 [Multi-domain]  Cd Length: 180  Bit Score: 83.73  E-value: 2.58e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 638 MKRL-EGYRnfcnKLWNASRYVLTN----DKLDLSEGDVEFSLADRWIESQFNRTVETFRTALSQYRFDLVANAIYEFTW 712
Cdd:cd07960    6 LKQVaEAYR----KIRNTFRFLLGNlndfDPAKDAVPYEELLELDRYALHRLNELIKEVREAYENYEFHKVYQALNNFCT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 713 DQFCDWYLELTKPIFF--KGTDVQRRGASRTLVNVLEKLLRLIHPVMPFITEEIWQKVKGFvgIEADTIMLQKFPQFDPL 790
Cdd:cd07960   82 VDLSAFYLDIIKDRLYcdAKDSLERRSAQTVLYHILDALLKLLAPILPFTAEEVWEHLPGE--KKEESVFLEDWPELPEE 159

                        170
                 ....*....|....*.
gi 493291867 791 AIDETAESQINFIKEV 806
Cdd:cd07960  160 WKDEELEEKWEKLLAL 175
MetG COG0143
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ...
 421-778 8.51e-18

Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439913 [Multi-domain]  Cd Length: 544  Bit Score: 87.86  E-value: 8.51e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 421 SWMRD-IQDWCISRQLWWGHRIPawyDEQGNV-YVardeaevrakhnlpadlplkqdedvldtWF-------SSglwtfs 491
Cdd:COG0143  217 SWLKEgLQDLSISRDFDWGIPVP---GDPGKVfYV----------------------------WFdaligyiSA------ 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 492 TLGWPEQTKELKMFHP----TDVLIT---GFDIIFF----WVArMIMFTmhfikdenGKPQVpfKTVYVTGLIRDEqGQK 560
Cdd:COG0143  260 TKGYADDRGLPEDFEKywpaPDTELVhfiGKDIIRFhaiiWPA-MLMAA--------GLPLP--KKVFAHGFLTVE-GEK 327

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 561 MSKSKGNVLDPIDMIDgislddllekrtgnmmqpqlaekiakatrkEFaegivahGTDALRFTLTALASNGRDINWDMKR 640
Cdd:COG0143  328 MSKSRGNVIDPDDLLD------------------------------RY-------GPDALRYYLLREVPFGQDGDFSWED 370

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 641 LEGyRN---FCNKLWN-ASRYV-LTNDKLD--LSEGDvEFSLADRWIESQFNRTVETFRTALSQYRFDLVANAIYEFTwd 713
Cdd:COG0143  371 FVA-RVnsdLANDLGNlASRTLsMIHKYFDgkVPEPG-ELTEADEELLAEAEAALEEVAEAMEAFEFRKALEEIMALA-- 446

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 493291867 714 QFCDWYLELTKP-IFFKGTDVQRRGAS-RTLVNVLEKLLRLIHPVMPFITEEIWQkvkgFVGIEADT 778
Cdd:COG0143  447 RAANKYIDETAPwKLAKDEDPERLATVlYTLLEALRILAILLKPFLPETAEKILE----QLGLEGDE 509
LeuRS_core cd00812
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ...
 43-182 1.63e-17

catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 173906 [Multi-domain]  Cd Length: 314  Bit Score: 84.61  E-value: 1.63e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  43 IAIPPPNvtGSLHMGHAFQQTLMDTLIRFNRMEGNNTLWQTGTDhagiATQMVVERkiAAEEGKTRHDYGREAFINKIwd 122
Cdd:cd00812    6 VMFPYPS--GALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFD----AFGLPAEN--AAIKIGRDPEDWTEYNIKKM-- 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 123 wkaysggtiSQQMRRLGNSIDWDRERFTMDEGLSNAVKEVFVRLHEEGLIYRGKRLVNWD 182
Cdd:cd00812   76 ---------KEQLKRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNWC 126
Val_tRNA-synt_C pfam10458
Valyl tRNA synthetase tRNA binding arm; This domain is found at the C-terminus of Valyl tRNA ...
 889-951 5.00e-17

Valyl tRNA synthetase tRNA binding arm; This domain is found at the C-terminus of Valyl tRNA synthetases.


Pssm-ID: 431296 [Multi-domain]  Cd Length: 66  Bit Score: 76.15  E-value: 5.00e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 493291867  889 EAELARLTKEMDKLKGEVARIEGKLSNEAFVAKAPEQVIAKEREKMQEYLSGLEKLQVQYQEI 951
Cdd:pfam10458   3 EKERARLEKELAKLQKEIERVQGKLANPGFVAKAPAEVVEEEKAKLAELEEQAEKLRERLSKL 65
LeuRS_core cd00812
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ...
 383-576 6.54e-12

catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 173906 [Multi-domain]  Cd Length: 314  Bit Score: 67.66  E-value: 6.54e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 383 MLTDQWYV--SVKPLAEVATKAVEdgEIQFVPKQYENLyfswMRDIQDwcISRQLWWGHRIPaWYD--EQ---GNVYVAR 455
Cdd:cd00812  127 KLLDQWFLkySETEWKEKLLKDLE--KLDGWPEEVRAM----QENWIG--CSRQRYWGTPIP-WTDtmESlsdSTWYYAR 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 456 deaeVRAKHNLPADLPLKQDEDvldtwfssglwtfstlgwpeqTKELKMFHPTDVLITGFDII----FFWVarmimFTMH 531
Cdd:cd00812  198 ----YTDAHNLEQPYEGDLEFD---------------------REEFEYWYPVDIYIGGKEHApnhlLYSR-----FNHK 247

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 493291867 532 FIKDENGKPQVPFKTVYVTGLIRDEqGQKMSKSKGNVLDPIDMID 576
Cdd:cd00812  248 ALFDEGLVTDEPPKGLIVQGMVLLE-GEKMSKSKGNVVTPDEAIK 291
Anticodon_Ia_Leu_AEc cd07959
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ...
 638-768 1.73e-11

Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.


Pssm-ID: 153413 [Multi-domain]  Cd Length: 117  Bit Score: 61.84  E-value: 1.73e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 638 MKRLEGYRNFCNKLwnasryvltndkLDLSEGDVEFSLADRWIESQFNRTVETFRTALSQYRFDLVANAIYeFTWDQFCD 717
Cdd:cd07959   10 ILRLERFYELAEEL------------IETEGELEELTFIDRWLLSRLNRLIKETTEAYENMQFREALKEGL-YELQNDLD 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 493291867 718 WYLELTKPIffKGTDVQRRgasrtlvnVLEKLLRLIHPVMPFITEEIWQKV 768
Cdd:cd07959   77 WYRERGGAG--MNKDLLRR--------FIEVWTRLLAPFAPHLAEEIWHEL 117
Anticodon_Ia_like cd07375
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ...
 639-757 7.68e-11

Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.


Pssm-ID: 153408 [Multi-domain]  Cd Length: 117  Bit Score: 60.21  E-value: 7.68e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 639 KRLEGYRNFCNKLWNASRYVLTNDKLDLSEGDVEF-SLADRWIESQFNRTVETFRTALSQYRFDLVANAIYEFTWDQfcD 717
Cdd:cd07375    2 ERLKQARAFLNRLYRLLSFFRKALGGTQPKWDNELlEEADRELLARLQEFIKRTTNALEALDPTTAVQELFKFTNEL--N 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 493291867 718 WYLELTKPIFFKGTDvqRRGASRTLVNVLEKLLRLIHPVM 757
Cdd:cd07375   80 WYLDELKPALQTEEL--REAVLAVLRAALVVLTKLLAPFT 117
MetRS_core cd00814
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ...
 44-176 2.42e-10

catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.


Pssm-ID: 173907 [Multi-domain]  Cd Length: 319  Bit Score: 62.93  E-value: 2.42e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  44 AIPPPNvtGSLHMGHAFQQTLMDTLIRFNRMEGNNTLWQTGTDHAGIATQMVverkiAAEEGKTRHDYGRE--AFINKIW 121
Cdd:cd00814    7 ALPYVN--GVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQK-----AEEEGVTPQELCDKyhEIFKDLF 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 493291867 122 DWkaysggtisqqmrrLGnsIDWDRERFTMDEGLSNAVKEVFVRLHEEGLIYRGK 176
Cdd:cd00814   80 KW--------------LN--ISFDYFIRTTSPRHKEIVQEFFKKLYENGYIYEGE 118
metG TIGR00398
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ...
 44-783 2.59e-10

methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ligase. This model appears to recognize the methionyl-tRNA synthetase of every species, including eukaryotic cytosolic and mitochondrial forms. The UPGMA difference tree calculated after search and alignment according to this model shows an unusual deep split between two families of MetG. One family contains forms from the Archaea, yeast cytosol, spirochetes, and E. coli, among others. The other family includes forms from yeast mitochondrion, Synechocystis sp., Bacillus subtilis, the Mycoplasmas, Aquifex aeolicus, and Helicobacter pylori. The E. coli enzyme is homodimeric, although monomeric forms can be prepared that are fully active. Activity of this enzyme in bacteria includes aminoacylation of fMet-tRNA with Met; subsequent formylation of the Met to fMet is catalyzed by a separate enzyme. Note that the protein from Aquifex aeolicus is split into an alpha (large) and beta (small) subunit; this model does not include the C-terminal region corresponding to the beta chain. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273058 [Multi-domain]  Cd Length: 530  Bit Score: 63.94  E-value: 2.59e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867   44 AIPPPNvtGSLHMGHAFQQTLMDTLIRFNRMEGNNTLWQTGTDHAGIATqmvvERKiAAEEGKTrhdygREAFINKIW-- 121
Cdd:TIGR00398   6 ALPYAN--GKPHLGHAYTTILADVYARYKRLRGYEVLFVCGTDEHGTKI----ELK-AEQEGLT-----PKELVDKYHee 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  122 ---DWKAYsggtisqqmrrlgnSIDWDRERFTMDEGLSNAVKEVFVRLHEEGLIYrgkrlvnwdpklhtaisdleveNKE 198
Cdd:TIGR00398  74 fkdDWKWL--------------NISFDRFIRTTDEEHKEIVQKIFQKLKENGYIY----------------------EKE 117

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  199 SKGslwhfryplangaktadgldylvvattrpetmlgdtavAVHPEDERYqaligksvilplanreipiIADEYVDrefg 278
Cdd:TIGR00398 118 IKQ--------------------------------------LYCPECEMF-------------------LPDRYVE---- 136

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  279 tgvvkitpahdfndyevgkrhglpmvnvmtlnadiraeaeiigtDGKPLSDYTAPIPADYQGLERfaarkkivadfealg 358
Cdd:TIGR00398 137 --------------------------------------------GTCPKCGSEDARGDHCEVCGR--------------- 157

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  359 lldQIKPHDLKVPYGDRGGVPIEPMLTDQWYVSV----KPLAEVATKAVEDGEIqfvPKQYENLYFSWMRD-IQDWCISR 433
Cdd:TIGR00398 158 ---HLEPTELINPRCKICGAKPELRDSEHYFFRLsafeKELEEWIRKNPESGSP---ASNVKNKAQNWLKGgLKDLAITR 231

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  434 QL-WWGHRIPawYDEQGNVYVardeaevrakhnlpadlplkqdedvldtWFSSGLWTFSTLGwpeqtkelkmfhptdvLI 512
Cdd:TIGR00398 232 DLvYWGIPVP--NDPNKVVYV----------------------------WFDALIGYISSLG----------------IL 265

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  513 TGFDIIF--FWVARMIMFTMHFIkdenGKPQVPFKTVY-----------------VTGLIRDEqGQKMSKSKGNVLDPID 573
Cdd:TIGR00398 266 SGDTEDWkkWWNNDEDAELIHFI----GKDIVRFHTIYwpamlmglglplptqvfSHGYLTVE-GGKMSKSLGNVVDPSD 340

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  574 MIDGIslddllekrtgnmmqpqlaekiakatrkefaegivahGTDALRFTLTALASNGRDINWDMKRLEGYRN--FCNKL 651
Cdd:TIGR00398 341 LLARF-------------------------------------GADILRYYLLKERPLGKDGDFSWEDFVERVNadLANKL 383

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  652 WN-ASRyVLT------NDKLDLSEGDVEFslaDRWIESQFNRTVETFRTALSQYRFDLVANAIYEFT------WDQFCDW 718
Cdd:TIGR00398 384 GNlLNR-TLGfikkyfNGVLPSEDITDEE---DKKLLKLINEALEQIDEAIESFEFRKALREIMKLAdrgnkyIDENKPW 459

                         730       740       750       760       770       780
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 493291867  719 YLELTKPiffkgtdvqrrgASRTLVNVLEKLLR----LIHPVMPFITEEIWQkvkgFVGIEADTIMLQK 783
Cdd:TIGR00398 460 ELFKQSP------------RLKELLAVCSMLIRvlsiLLYPIMPKLSEKILK----FLNFELEWDFKLK 512
tRNA-synt_1_2 pfam13603
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ...
 225-355 1.16e-09

Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.


Pssm-ID: 433342 [Multi-domain]  Cd Length: 185  Bit Score: 58.71  E-value: 1.16e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  225 VATTRPETMLGDTAVAVHPE----------DERYQALI-----------------------GKSVILPLANREIPI-IAD 270
Cdd:pfam13603  25 VFTTRPDTLMGVTFVALAPEhplveklaekNPEVAAFIeeckntseiertsetkekegvftGLYAIHPITGEKIPIwIAN 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  271 eYVDREFGTGVVKITPAHDFNDYEVGKRHGLPMVNV-----MTLNADIRAEAeiigtdgkplsdYTAPIP----ADYQGL 341
Cdd:pfam13603 105 -FVLMEYGTGAVMAVPAHDQRDFEFAKKYNLPIKPViqpedGDLDLDIMTEA------------YTEEGIlvnsGEFDGL 171

                         170
                  ....*....|....
gi 493291867  342 ERFAARKKIVADFE 355
Cdd:pfam13603 172 DSEEAKEAIIKKLE 185
PRK12267 PRK12267
methionyl-tRNA synthetase; Reviewed
 491-791 7.45e-09

methionyl-tRNA synthetase; Reviewed


Pssm-ID: 237028 [Multi-domain]  Cd Length: 648  Bit Score: 59.43  E-value: 7.45e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 491 STLGWPEQTKELKM-FHPTDVLITGFDIIFF----WVArMIMFTmhfikdenGKPqvPFKTVYVTG-LIRDeqGQKMSKS 564
Cdd:PRK12267 237 TALGYGSDDDELFKkFWPADVHLVGKDILRFhaiyWPI-MLMAL--------GLP--LPKKVFAHGwWLMK--DGKMSKS 303

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 565 KGNVLDPIDMIDgislddllekrtgnmmqpqlaekiakatrkefaegivAHGTDALRFTLTALASNGRD----------- 633
Cdd:PRK12267 304 KGNVVDPEELVD-------------------------------------RYGLDALRYYLLREVPFGSDgdfspealver 346

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 634 INWDMkrlegyrnfCNKLWN-ASRyVLT------NDKLDLSEGDVEFslaDRWIESQFNRTVETFRTALSQYRFDLVANA 706
Cdd:PRK12267 347 INSDL---------ANDLGNlLNR-TVAminkyfDGEIPAPGNVTEF---DEELIALAEETLKNYEELMEELQFSRALEE 413

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 707 IYEFTwdQFCDWYLELTKP-IFFKgtDVQRRGASRTLVNVLEKLLR----LIHPVMPFITEEIWQKvkgfVGIEADTIML 781
Cdd:PRK12267 414 VWKLI--SRANKYIDETAPwVLAK--DEGKKERLATVMYHLAESLRkvavLLSPFMPETSKKIFEQ----LGLEEELTSW 485

                        330
                 ....*....|
gi 493291867 782 QKFPQFDPLA 791
Cdd:PRK12267 486 ESLLEWGGLP 495
tRNA-synt_1g pfam09334
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
 44-213 1.25e-08

tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.


Pssm-ID: 401322 [Multi-domain]  Cd Length: 387  Bit Score: 58.07  E-value: 1.25e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867   44 AIPPPNvtGSLHMGHAFQQTLMDTLIRFNRMEGNNTLWQTGTDHAGIATQMVverkiAAEEGKTRHDYGREAFINKIWDW 123
Cdd:pfam09334   6 ALPYAN--GPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELK-----AEKEGITPEELVDRYHEIHREDF 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  124 KAYSggtISQQmrrlgnsiDWDRerfTMDEGLSNAVKEVFVRLHEEGLIYRGKRLVNWDPKLHTAISDLEVEnkeskGSL 203
Cdd:pfam09334  79 KKFN---ISFD--------DYGR---TTSERHHELVQEFFLKLYENGYIYEKEIEQFYCPSDERFLPDRYVE-----GTC 139

                         170
                  ....*....|
gi 493291867  204 WHFRYPLANG 213
Cdd:pfam09334 140 PHCGSEDARG 149
PRK12267 PRK12267
methionyl-tRNA synthetase; Reviewed
 50-176 3.82e-07

methionyl-tRNA synthetase; Reviewed


Pssm-ID: 237028 [Multi-domain]  Cd Length: 648  Bit Score: 54.04  E-value: 3.82e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  50 VTGSLHMGHAFQQTLMDTLIRFNRMEGNNTLWQTGTDHAGiatQMVVErkIAAEEGKTRhdygreafinkiwdwKAYSGG 129
Cdd:PRK12267  15 PNGKPHIGHAYTTIAADALARYKRLQGYDVFFLTGTDEHG---QKIQQ--AAEKAGKTP---------------QEYVDE 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 493291867 130 tISQQMRRLGNSIDWDRERF--TMDEGLSNAVKEVFVRLHEEGLIYRGK 176
Cdd:PRK12267  75 -ISAGFKELWKKLDISYDKFirTTDERHKKVVQKIFEKLYEQGDIYKGE 122
MetRS_core cd00814
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ...
 412-581 1.66e-06

catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.


Pssm-ID: 173907 [Multi-domain]  Cd Length: 319  Bit Score: 50.99  E-value: 1.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 412 PKQYENLYFSWMRD-IQDWCISRQLW-WGHRIPAwyDEQGNVYVardeaevrakhnlpadlplkqdedvldtWFS----- 484
Cdd:cd00814  164 PENARNEVLSWLKEgLKDLSITRDLFdWGIPVPL--DPGKVIYV----------------------------WFDaligy 213

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 485 -------SGLWTFSTLGWPEQTKelkmfhptDVLITGFDIIFF----WVArMIMFTmhfikdenGKPqvPFKTVYVTGLI 553
Cdd:cd00814  214 isatgyyNEEWGNSWWWKDGWPE--------LVHFIGKDIIRFhaiyWPA-MLLGA--------GLP--LPTRIVAHGYL 274

                        170       180
                 ....*....|....*....|....*...
gi 493291867 554 RDEqGQKMSKSKGNVLDPIDMIDGISLD 581
Cdd:cd00814  275 TVE-GKKMSKSRGNVVDPDDLLERYGAD 301
tRNA-synt_1g pfam09334
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
 365-583 3.54e-06

tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.


Pssm-ID: 401322 [Multi-domain]  Cd Length: 387  Bit Score: 50.37  E-value: 3.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  365 PHDLKVPYGDRGGVPIEPMLTDQWYVSVKPLAEVATKAVEDGEIQFvPKQYENLYFSWMRD-IQDWCISRQLWWGHRIPA 443
Cdd:pfam09334 161 PTELINPKCVICGTTPEVKETEHYFFDLSKFQDKLREWIEENNPEW-PENVKNMVLEWLKEgLKDRAISRDLDWGIPVPG 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  444 wyDEQGNVYVardeaevrakhnlpadlplkqdedvldtWFSSglwtfsTLGWPEQTKELkmfhptdvliTGFDIIF--FW 521
Cdd:pfam09334 240 --AEGKVFYV----------------------------WLDA------PIGYISATKEL----------SGNEEKWkeWW 273

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 493291867  522 VARMIMFTMHFIkdenGKPQVPFKTVYVTGLIRDEQ----------------GQKMSKSKGNVLDPIDMIDGISLDDL 583
Cdd:pfam09334 274 PNDPDTELVHFI----GKDIIYFHTIFWPAMLLGAGyrlpttvfahgyltyeGGKMSKSRGNVVWPSEALDRFPPDAL 347
Anticodon_Ia_Leu_BEm cd07958
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ...
 636-767 3.77e-06

Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.


Pssm-ID: 153412 [Multi-domain]  Cd Length: 117  Bit Score: 46.83  E-value: 3.77e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 636 WDMKRLEGYRNFCNKLWN-ASRYVltnDKLDLSEGDVEFSLADRWIESQFNRTV-------ETFR--TALSqyrfdlvan 705
Cdd:cd07958    1 WSDSGVEGAYRFLNRVWRlVTELA---EALAAPAAAAELSEEDKELRRKLHKTIkkvtediERLRfnTAIA--------- 68

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 493291867 706 AIYEFTwdqfcdwyLELTKpifFKGTDVQRRGASRTlvnVLEKLLRLIHPVMPFITEEIWQK 767
Cdd:cd07958   69 ALMELV--------NALYK---YKKKDAQHAAVLRE---ALETLVLLLAPFAPHIAEELWEE 116
argS PRK01611
arginyl-tRNA synthetase; Reviewed
 551-709 6.79e-06

arginyl-tRNA synthetase; Reviewed


Pssm-ID: 234964 [Multi-domain]  Cd Length: 507  Bit Score: 49.77  E-value: 6.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 551 GLIRDEQGQKMSKSKGNVldpidmidgISLDDLLEkrtgnmmqpqlaEKIAKAtRKEFAEGIVAH--GTDALRFtltALA 628
Cdd:PRK01611 313 GLVRGGEGVKMSTRAGNV---------VTLDDLLD------------EAVGRA-RELIEEKEIAEavGIDAVRY---FDL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 629 SNGRD----INWD-MKRLEG-------Y---------RNFCNKLWNASRYVLTNDKldlsegdvEFSLAdRWIeSQFNRT 687
Cdd:PRK01611 368 SRSRDkdldFDLDlALSFEGnnppyvqYaharicsilRKAAEAGIDLLLALLTEEE--------EKELI-KKL-AEFPEV 437

                        170       180
                 ....*....|....*....|..
gi 493291867 688 VEtfrTALSQYRFDLVANAIYE 709
Cdd:PRK01611 438 VE---SAAEELEPHRIANYLYE 456
PLN02224 PLN02224
methionine-tRNA ligase
 36-175 3.05e-05

methionine-tRNA ligase


Pssm-ID: 177869 [Multi-domain]  Cd Length: 616  Bit Score: 47.79  E-value: 3.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867  36 INAPSYCIAIPPpnvtgslHMGHAFQQTLMDTLIRFNRMEGNNTLWQTGTDHAG--IATQmvverkiAAEEGKTRHDYgr 113
Cdd:PLN02224  73 LTTPLYYVNAPP-------HMGSAYTTIAADSIARFQRLLGKKVIFITGTDEHGekIATS-------AAANGRNPPEH-- 136

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 493291867 114 eafinkiwdwkaysGGTISQQMRRLGNSIDWDRERF--TMDEGLSNAVKEVFVRLHEEGLIYRG 175
Cdd:PLN02224 137 --------------CDIISQSYRTLWKDLDIAYDKFirTTDPKHEAIVKEFYARVFANGDIYRA 186
ArgS COG0018
Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Arginyl-tRNA ...
 551-643 1.69e-04

Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Arginyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439789 [Multi-domain]  Cd Length: 574  Bit Score: 45.52  E-value: 1.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 551 GLIRDEQGQKMSKSKGNVldpidmidgISLDDLLEkrtgnMMQPQLAEKIAKATRKEFAEGIVAHGTDALRFtltALASN 630
Cdd:COG0018  370 GMVNLRDGEKMSTRAGTV---------VTLDDLLD-----EAVERAREIIEEKSEEEKEEIAEQVGIDAVRY---FDLSR 432

                         90
                 ....*....|....*...
gi 493291867 631 GR----DINWD-MKRLEG 643
Cdd:COG0018  433 SRdkdlDFDLDlALSFEG 450
Anticodon_Ia_Met cd07957
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA ...
 676-766 1.89e-04

Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA synthetases (MetRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon (CAU). MetRS catalyzes the transfer of methionine to the 3'-end of its tRNA.


Pssm-ID: 153411 [Multi-domain]  Cd Length: 129  Bit Score: 42.09  E-value: 1.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 676 ADRWIESQFNRTVETFRTALSQYRFDLVANAIYEFTwdQFCDWYLELTKP-IFFKGTDVQRRGAS-RTLVNVLEKLLRLI 753
Cdd:cd07957   37 EDEELLEEAEELLEEVAEAMEELEFRKALEEIMELA--RAANKYIDETAPwKLAKEEDPERLATVlYVLLELLRILAILL 114

                         90
                 ....*....|...
gi 493291867 754 HPVMPFITEEIWQ 766
Cdd:cd07957  115 SPFMPETAEKILD 127
lysK PRK00750
lysyl-tRNA synthetase; Reviewed
 537-585 2.05e-04

lysyl-tRNA synthetase; Reviewed


Pssm-ID: 234829 [Multi-domain]  Cd Length: 510  Bit Score: 45.19  E-value: 2.05e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 493291867 537 NGKPQVPFktVYvtGLIRDEQGQKMSKSKGNVldpidmidgISLDDLLE 585
Cdd:PRK00750 261 GGEPPEPF--VY--ELFLDKKGEKISKSKGNV---------ITIEDWLE 296
GatD cd08962
GatD subunit of archaeal Glu-tRNA amidotransferase; GatD is involved in the alternative ...
 592-628 3.26e-04

GatD subunit of archaeal Glu-tRNA amidotransferase; GatD is involved in the alternative synthesis of Gln-tRNA(Gln) in archaea via the transamidation of incorrectly charged Glu-tRNA(Gln). GatD is active as a dimer, and it provides the amino group required for this reaction. GatD is related to bacterial L-asparaginases (amidohydrolases), which catalyze the hydrolysis of asparagine to aspartic acid and ammonia. This CD spans both the L-asparaginase_like domain and an N-terminal supplementary domain.


Pssm-ID: 199206 [Multi-domain]  Cd Length: 402  Bit Score: 44.15  E-value: 3.26e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 493291867 592 MQPQLAEKIAKATRKEFAEG----IVAHGTDALRFTLTALA 628
Cdd:cd08962  128 MTPEYWVKIAEAVYKEIKEGadgvVVAHGTDTMHYTASALS 168
PRK04183 PRK04183
Glu-tRNA(Gln) amidotransferase subunit GatD;
592-628 7.60e-04

Glu-tRNA(Gln) amidotransferase subunit GatD;


Pssm-ID: 235245 [Multi-domain]  Cd Length: 419  Bit Score: 42.91  E-value: 7.60e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 493291867 592 MQPQLAEKIAKATRKEFAEG----IVAHGTDALRFTLTALA 628
Cdd:PRK04183 133 MTPEYWVEIAEAVYEEIKNGadgvVVAHGTDTMHYTAAALS 173
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
794-952 1.03e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 43.08  E-value: 1.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 794 ETAESQINFIKEVIV-----------AVRNIRAESNI-APSKGLDLIARNFSADEVSILNANEVLLKSMAKLDSVKvlEN 861
Cdd:COG3206  171 EEARKALEFLEEQLPelrkeleeaeaALEEFRQKNGLvDLSEEAKLLLQQLSELESQLAEARAELAEAEARLAALR--AQ 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493291867 862 GENAPLSVAKLVANGEILIPMAGFINKEAELARLTK--------------EMDKLKG----EVARIEGKLSNEAFVAKAP 923
Cdd:COG3206  249 LGSGPDALPELLQSPVIQQLRAQLAELEAELAELSArytpnhpdvialraQIAALRAqlqqEAQRILASLEAELEALQAR 328

                        170       180
                 ....*....|....*....|....*....
gi 493291867 924 EQVIAKEREKMQEYLSGLEKLQVQYQEIE 952
Cdd:COG3206  329 EASLQAQLAQLEARLAELPELEAELRRLE 357
LysS COG1384
Lysyl-tRNA synthetase, class I [Translation, ribosomal structure and biogenesis]; Lysyl-tRNA ...
 537-585 1.60e-03

Lysyl-tRNA synthetase, class I [Translation, ribosomal structure and biogenesis]; Lysyl-tRNA synthetase, class I is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 440994 [Multi-domain]  Cd Length: 525  Bit Score: 42.10  E-value: 1.60e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 493291867 537 NGKPQVPFktVYvtGLIRDEQGQKMSKSKGNvldpidmidGISLDDLLE 585
Cdd:COG1384  268 GGEPPEGF--VY--ELFLDENGEKISKSKGN---------GLTVEEWLE 303
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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