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Conserved domains on  [gi|492987468|ref|WP_006079879|]
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MULTISPECIES: 3-isopropylmalate dehydrogenase [Shewanella]

Protein Classification

3-isopropylmalate dehydrogenase( domain architecture ID 10011514)

3-isopropylmalate dehydrogenase catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate

CATH:  3.40.718.10
EC:  1.1.1.85
Gene Symbol:  leuB
Gene Ontology:  GO:0003862|GO:0046872|GO:0051287
SCOP:  4000791

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 1-363 0e+00

3-isopropylmalate dehydrogenase; Provisional


:

Pssm-ID: 234832  Cd Length: 358  Bit Score: 666.42  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468   1 MSYQVAVLAGDGIGPEVMAEARKVLREVEARFDLNIEYTQYDVGGIAIDNHGCPLPDATLKGCEAADAILFGSVGGPKWE 80
Cdd:PRK00772   1 MTYKIAVLPGDGIGPEVMAEAVKVLDAVAEKFGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKWD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468  81 KLPPNEQPERGaLLPLRGHFELFCNLRPAKLHDGLEHMSPLRSDIsARGFDVLCVRELTGGIYFGKPKGRQGEGENEEAF 160
Cdd:PRK00772  81 NLPPDVRPERG-LLALRKELGLFANLRPAKLYPGLADASPLKPEI-VAGLDILIVRELTGGIYFGEPRGREGLGGEERAF 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 161 DTMRYSRREISRIARIAFEAARGRRKKVTSVDKANVLACSVLWRQVVEEVAVDFPDVELEHIYIDNATMQLLRRPDEFDV 240
Cdd:PRK00772 159 DTMVYTREEIERIARVAFELARKRRKKVTSVDKANVLESSRLWREVVTEVAKEYPDVELSHMYVDNAAMQLVRNPKQFDV 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 241 MLCSNLFGDILSDEIAMLTGSMGLLSSASMNSSGFGLFEPAGGSAPDIAGKGIANPVAQILSAALMLRHSLKQEEAASAI 320
Cdd:PRK00772 239 IVTENLFGDILSDEAAMLTGSLGMLPSASLGESGPGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEEAADAI 318

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 492987468 321 ERAVSKALNSGYLTGELLSSDKRseaKSTAEMGDFIANAIKEG 363
Cdd:PRK00772 319 EAAVEKVLAQGYRTADIAEGGGK---VSTSEMGDAILAALAEG 358
 
Name Accession Description Interval E-value
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 1-363 0e+00

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 666.42  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468   1 MSYQVAVLAGDGIGPEVMAEARKVLREVEARFDLNIEYTQYDVGGIAIDNHGCPLPDATLKGCEAADAILFGSVGGPKWE 80
Cdd:PRK00772   1 MTYKIAVLPGDGIGPEVMAEAVKVLDAVAEKFGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKWD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468  81 KLPPNEQPERGaLLPLRGHFELFCNLRPAKLHDGLEHMSPLRSDIsARGFDVLCVRELTGGIYFGKPKGRQGEGENEEAF 160
Cdd:PRK00772  81 NLPPDVRPERG-LLALRKELGLFANLRPAKLYPGLADASPLKPEI-VAGLDILIVRELTGGIYFGEPRGREGLGGEERAF 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 161 DTMRYSRREISRIARIAFEAARGRRKKVTSVDKANVLACSVLWRQVVEEVAVDFPDVELEHIYIDNATMQLLRRPDEFDV 240
Cdd:PRK00772 159 DTMVYTREEIERIARVAFELARKRRKKVTSVDKANVLESSRLWREVVTEVAKEYPDVELSHMYVDNAAMQLVRNPKQFDV 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 241 MLCSNLFGDILSDEIAMLTGSMGLLSSASMNSSGFGLFEPAGGSAPDIAGKGIANPVAQILSAALMLRHSLKQEEAASAI 320
Cdd:PRK00772 239 IVTENLFGDILSDEAAMLTGSLGMLPSASLGESGPGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEEAADAI 318

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 492987468 321 ERAVSKALNSGYLTGELLSSDKRseaKSTAEMGDFIANAIKEG 363
Cdd:PRK00772 319 EAAVEKVLAQGYRTADIAEGGGK---VSTSEMGDAILAALAEG 358
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 2-360 0e+00

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 560.79  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468   2 SYQVAVLAGDGIGPEVMAEARKVLREVEARFDLNIEYTQYDVGGIAIDNHGCPLPDATLKGCEAADAILFGSVGGPKWek 81
Cdd:COG0473    1 TYKIAVLPGDGIGPEVVAAALKVLEAAAERFGLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKW-- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468  82 lPPNEQPERGaLLPLRGHFELFCNLRPAKLHDGLEHmsPLRSDIsARGFDVLCVRELTGGIYFGKPKGRQGEGENEEAFD 161
Cdd:COG0473   79 -DDGVRPESG-LLALRKELDLYANLRPAKLYPGLPS--PLKPEI-VEGIDLVIVRENTEGLYFGIGGRIGTGTGEEVAID 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 162 TMRYSRREISRIARIAFEAARGRRKKVTSVDKANVLA-CSVLWRQVVEEVAVDFPDVELEHIYIDNATMQLLRRPDEFDV 240
Cdd:COG0473  154 TRVYTRKGIERIARYAFELARKRRKKVTSVDKANVLKlTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDV 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 241 MLCSNLFGDILSDEIAMLTGSMGLLSSASMNSSGFGLFEPAGGSAPDIAGKGIANPVAQILSAALMLRHsLKQEEAASAI 320
Cdd:COG0473  234 IVTENLFGDILSDLAAGLTGSLGLAPSANIGDEGKALFEPVHGSAPDIAGKGIANPIATILSAAMMLRH-LGEEEAADAI 312

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 492987468 321 ERAVSKALNSGYLTGELLSSdkrseaKSTAEMGDFIANAI 360
Cdd:COG0473  313 EAAVEKVLAEGVRTPDLGGK------AGTSEMGDAIIAAL 346
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 5-356 0e+00

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 555.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468    5 VAVLAGDGIGPEVMAEARKVLREVEARFDLNIEYTQYDVGGIAIDNHGCPLPDATLKGCEAADAILFGSVGGPKWEKLPP 84
Cdd:TIGR00169   2 IAVLPGDGIGPEVMAQALKVLKAVAERFGLKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKWDNLPR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468   85 NEQPERGaLLPLRGHFELFCNLRPAKLHDGLEHMSPLRSDIsARGFDVLCVRELTGGIYFGKPKGRQGEGEneeAFDTMR 164
Cdd:TIGR00169  82 DQRPEQG-LLKLRKSLDLFANLRPAKVFPGLEDLSPLKEEI-AKGVDFVVVRELTGGIYFGEPKGREGEGE---AWDTEV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468  165 YSRREISRIARIAFEAARGRRKKVTSVDKANVLACSVLWRQVVEEVAVDFPDVELEHIYIDNATMQLLRRPDEFDVMLCS 244
Cdd:TIGR00169 157 YTVPEIERIARVAFEMARKRRKKVTSVDKANVLESSRLWRKTVEEIAKEYPDVELEHQYIDNAAMQLVKSPTQFDVVVTS 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468  245 NLFGDILSDEIAMLTGSMGLLSSASMNSSGFGLFEPAGGSAPDIAGKGIANPVAQILSAALMLRHSLKQEEAASAIERAV 324
Cdd:TIGR00169 237 NLFGDILSDEASVITGSLGMLPSASLGSDGFGLFEPVHGSAPDIAGKGIANPIAQILSAAMLLRYSFNLEEAADAIEAAV 316

                         330       340       350
                  ....*....|....*....|....*....|..
gi 492987468  325 SKALNSGYLTGELLSSDkrSEAKSTAEMGDFI 356
Cdd:TIGR00169 317 KKVLAEGYRTPDLGSSA--TTAVGTAEMGEEL 346
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
5-356 1.30e-173

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 486.42  E-value: 1.30e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468    5 VAVLAGDGIGPEVMAEARKVLREVEARFDLNIEYTQYDVGGIAIDNHGCPLPDATLKGCEAADAILFGSVGGPKWEklPP 84
Cdd:pfam00180   2 IAVLPGDGIGPEVMAAALKVLKAALEKAPLEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWD--PA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468   85 NEQPERGaLLPLRGHFELFCNLRPAKLHDGLEHMSPLRSDIsaRGFDVLCVRELTGGIYFGKPKGRQGeGENEEAFDTMR 164
Cdd:pfam00180  80 GVRPENG-LLALRKELGLFANLRPAKVFPPLGDASPLKNEV--EGVDIVIVRELTGGIYFGIEKGIKG-SGNEVAVDTKL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468  165 YSRREISRIARIAFEAARGR-RKKVTSVDKANVLACSVLWRQVVEEVA-VDFPDVELEHIYIDNATMQLLRRPDEFDVML 242
Cdd:pfam00180 156 YSRDEIERIARVAFELARKRgRKKVTSVDKANVLKSSDLWRKIVTEVAkAEYPDVELEHQLVDNAAMQLVKNPSQFDVIV 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468  243 CSNLFGDILSDEIAMLTGSMGLLSSASMNSSGFGLFEPAGGSAPDIAGKGIANPVAQILSAALMLRHSLKQEEAASAIER 322
Cdd:pfam00180 236 TPNLFGDILSDEASMLTGSLGLLPSASLGANGFGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEDAADKIEA 315

                         330       340       350
                  ....*....|....*....|....*....|....
gi 492987468  323 AVSKALNSGYLTGELLSSDKrseAKSTAEMGDFI 356
Cdd:pfam00180 316 AVLKVLESGIRTGDLAGSAT---YVSTSEFGEAV 346
AksF2_Meth NF040626
homoisocitrate dehydrogenase;
3-362 5.45e-82

homoisocitrate dehydrogenase;


Pssm-ID: 468598  Cd Length: 332  Bit Score: 253.12  E-value: 5.45e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468   3 YQVAVLAGDGIGPEVMAEARKVLReveaRFDLNIEYTQYDVGGIAIDNHGCPLPDATLKGCEAADAILFGSVGGPKWEKL 82
Cdd:NF040626   2 YKITVIPGDGIGKEVMEAALYVLD----ALDLNFDFIEAEAGRECFKKNGTTIPEETIKIAKKSDATLFGAVTSTPGQKS 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468  83 PpneqpergaLLPLRGHFELFCNLRPAKLHDGLEhmsPLRSDIsargfDVLCVRELTGGIYfgkpKGRQGEGENEEAFDT 162
Cdd:NF040626  78 P---------IITLRKELDLYANLRPIKSYEGIN---CLFKDL-----DFLIVRENTEGLY----SGLEEEYTEEKAIAE 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 163 MRYSRREISRIARIAFEAARGR-RKKVTSVDKANVLA-CSVLWRQVVEEVAVDFPDVELEHIYIDNATMQLLRRPDEFDV 240
Cdd:NF040626 137 RVITRKASERICKFAFEYAIKLgRKKVTAVHKANVLKkTDGIFKDTFYKVAKDYPQIETEDYYVDATAMYLITKPQDFDV 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 241 MLCSNLFGDILSDEIAMLTGSMGLLSSASMNSSGfGLFEPAGGSAPDIAGKGIANPVAQILSAALMLRHsLKQEEAASAI 320
Cdd:NF040626 217 IVTTNLFGDILSDEAAGLVGGLGLAPSANIGDKN-GLFEPVHGSAPDIAGKNIANPIAMILSASMMLDY-LGETYEANKL 294

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 492987468 321 ERAVSKALNSgyltGELLSSDKRSEAKsTAEMgdfiANAIKE 362
Cdd:NF040626 295 ENALEKVLRE----GKVVTPDLGGNAK-TMEM----ANEIKK 327
AksF_Meth NF040619
homoisocitrate dehydrogenase;
3-345 6.63e-71

homoisocitrate dehydrogenase;


Pssm-ID: 468591  Cd Length: 332  Bit Score: 224.64  E-value: 6.63e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468   3 YQVAVLAGDGIGPEVMAEARKVLREVEarfdlNIEYTQYDVGGIAIDNHGCPLPDATLKGCEAADAILFGSVGGPKwekl 82
Cdd:NF040619   2 PKICVIEGDGIGKEVIPETVRVLKELG-----DFEFIKGEAGLECFKKYGDAIPEETIEKAKECDAILFGAVTTPK---- 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468  83 pPNE---QPERGALLPLRGHFELFCNLRPaklhdglehMSPLRSDISARGFDVLCVRELTGGIYFGKPKGRQgegENEEA 159
Cdd:NF040619  73 -PTElknKNYKSPILTLRKELDLYANVRP---------INNFGDGQDVKNIDFVIIRENTEGLYVGREYYDE---ENEIA 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 160 FDTMRYSRREISRIARIAFE-AARGRRKKVTSVDKANVLACSV-LWRQVVEEVAVDF--PDVELEHIYIDNATMQLLRRP 235
Cdd:NF040619 140 IAERIISKKGSERIIKFAFEyAKKNNRKKVSCIHKANVLRVTDgLFLEIFNEIKKKYknFNIEADDYLVDATAMYLIKNP 219

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 236 DEFDVMLCSNLFGDILSDEIAMLTGSMGLLSSASMNSSgFGLFEPAGGSAPDIAGKGIANPVAQILSAALMLRHsLKQEE 315
Cdd:NF040619 220 EMFDVIVTTNLFGDILSDEASGLIGGLGLAPSANIGDK-KGLFEPVHGSAPDIAGKGIANPIATILSAAMMLDY-LGMKE 297

                        330       340       350
                 ....*....|....*....|....*....|
gi 492987468 316 AASAIERAVSKALNSGYLTGELLSSDKRSE 345
Cdd:NF040619 298 KGDLIREAVKKCLENGKVTPDLGGNLKTKE 327
 
Name Accession Description Interval E-value
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 1-363 0e+00

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 666.42  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468   1 MSYQVAVLAGDGIGPEVMAEARKVLREVEARFDLNIEYTQYDVGGIAIDNHGCPLPDATLKGCEAADAILFGSVGGPKWE 80
Cdd:PRK00772   1 MTYKIAVLPGDGIGPEVMAEAVKVLDAVAEKFGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKWD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468  81 KLPPNEQPERGaLLPLRGHFELFCNLRPAKLHDGLEHMSPLRSDIsARGFDVLCVRELTGGIYFGKPKGRQGEGENEEAF 160
Cdd:PRK00772  81 NLPPDVRPERG-LLALRKELGLFANLRPAKLYPGLADASPLKPEI-VAGLDILIVRELTGGIYFGEPRGREGLGGEERAF 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 161 DTMRYSRREISRIARIAFEAARGRRKKVTSVDKANVLACSVLWRQVVEEVAVDFPDVELEHIYIDNATMQLLRRPDEFDV 240
Cdd:PRK00772 159 DTMVYTREEIERIARVAFELARKRRKKVTSVDKANVLESSRLWREVVTEVAKEYPDVELSHMYVDNAAMQLVRNPKQFDV 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 241 MLCSNLFGDILSDEIAMLTGSMGLLSSASMNSSGFGLFEPAGGSAPDIAGKGIANPVAQILSAALMLRHSLKQEEAASAI 320
Cdd:PRK00772 239 IVTENLFGDILSDEAAMLTGSLGMLPSASLGESGPGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEEAADAI 318

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 492987468 321 ERAVSKALNSGYLTGELLSSDKRseaKSTAEMGDFIANAIKEG 363
Cdd:PRK00772 319 EAAVEKVLAQGYRTADIAEGGGK---VSTSEMGDAILAALAEG 358
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 2-360 0e+00

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 560.79  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468   2 SYQVAVLAGDGIGPEVMAEARKVLREVEARFDLNIEYTQYDVGGIAIDNHGCPLPDATLKGCEAADAILFGSVGGPKWek 81
Cdd:COG0473    1 TYKIAVLPGDGIGPEVVAAALKVLEAAAERFGLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKW-- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468  82 lPPNEQPERGaLLPLRGHFELFCNLRPAKLHDGLEHmsPLRSDIsARGFDVLCVRELTGGIYFGKPKGRQGEGENEEAFD 161
Cdd:COG0473   79 -DDGVRPESG-LLALRKELDLYANLRPAKLYPGLPS--PLKPEI-VEGIDLVIVRENTEGLYFGIGGRIGTGTGEEVAID 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 162 TMRYSRREISRIARIAFEAARGRRKKVTSVDKANVLA-CSVLWRQVVEEVAVDFPDVELEHIYIDNATMQLLRRPDEFDV 240
Cdd:COG0473  154 TRVYTRKGIERIARYAFELARKRRKKVTSVDKANVLKlTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDV 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 241 MLCSNLFGDILSDEIAMLTGSMGLLSSASMNSSGFGLFEPAGGSAPDIAGKGIANPVAQILSAALMLRHsLKQEEAASAI 320
Cdd:COG0473  234 IVTENLFGDILSDLAAGLTGSLGLAPSANIGDEGKALFEPVHGSAPDIAGKGIANPIATILSAAMMLRH-LGEEEAADAI 312

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 492987468 321 ERAVSKALNSGYLTGELLSSdkrseaKSTAEMGDFIANAI 360
Cdd:COG0473  313 EAAVEKVLAEGVRTPDLGGK------AGTSEMGDAIIAAL 346
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 5-356 0e+00

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 555.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468    5 VAVLAGDGIGPEVMAEARKVLREVEARFDLNIEYTQYDVGGIAIDNHGCPLPDATLKGCEAADAILFGSVGGPKWEKLPP 84
Cdd:TIGR00169   2 IAVLPGDGIGPEVMAQALKVLKAVAERFGLKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKWDNLPR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468   85 NEQPERGaLLPLRGHFELFCNLRPAKLHDGLEHMSPLRSDIsARGFDVLCVRELTGGIYFGKPKGRQGEGEneeAFDTMR 164
Cdd:TIGR00169  82 DQRPEQG-LLKLRKSLDLFANLRPAKVFPGLEDLSPLKEEI-AKGVDFVVVRELTGGIYFGEPKGREGEGE---AWDTEV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468  165 YSRREISRIARIAFEAARGRRKKVTSVDKANVLACSVLWRQVVEEVAVDFPDVELEHIYIDNATMQLLRRPDEFDVMLCS 244
Cdd:TIGR00169 157 YTVPEIERIARVAFEMARKRRKKVTSVDKANVLESSRLWRKTVEEIAKEYPDVELEHQYIDNAAMQLVKSPTQFDVVVTS 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468  245 NLFGDILSDEIAMLTGSMGLLSSASMNSSGFGLFEPAGGSAPDIAGKGIANPVAQILSAALMLRHSLKQEEAASAIERAV 324
Cdd:TIGR00169 237 NLFGDILSDEASVITGSLGMLPSASLGSDGFGLFEPVHGSAPDIAGKGIANPIAQILSAAMLLRYSFNLEEAADAIEAAV 316

                         330       340       350
                  ....*....|....*....|....*....|..
gi 492987468  325 SKALNSGYLTGELLSSDkrSEAKSTAEMGDFI 356
Cdd:TIGR00169 317 KKVLAEGYRTPDLGSSA--TTAVGTAEMGEEL 346
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
5-356 1.30e-173

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 486.42  E-value: 1.30e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468    5 VAVLAGDGIGPEVMAEARKVLREVEARFDLNIEYTQYDVGGIAIDNHGCPLPDATLKGCEAADAILFGSVGGPKWEklPP 84
Cdd:pfam00180   2 IAVLPGDGIGPEVMAAALKVLKAALEKAPLEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWD--PA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468   85 NEQPERGaLLPLRGHFELFCNLRPAKLHDGLEHMSPLRSDIsaRGFDVLCVRELTGGIYFGKPKGRQGeGENEEAFDTMR 164
Cdd:pfam00180  80 GVRPENG-LLALRKELGLFANLRPAKVFPPLGDASPLKNEV--EGVDIVIVRELTGGIYFGIEKGIKG-SGNEVAVDTKL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468  165 YSRREISRIARIAFEAARGR-RKKVTSVDKANVLACSVLWRQVVEEVA-VDFPDVELEHIYIDNATMQLLRRPDEFDVML 242
Cdd:pfam00180 156 YSRDEIERIARVAFELARKRgRKKVTSVDKANVLKSSDLWRKIVTEVAkAEYPDVELEHQLVDNAAMQLVKNPSQFDVIV 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468  243 CSNLFGDILSDEIAMLTGSMGLLSSASMNSSGFGLFEPAGGSAPDIAGKGIANPVAQILSAALMLRHSLKQEEAASAIER 322
Cdd:pfam00180 236 TPNLFGDILSDEASMLTGSLGLLPSASLGANGFGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEDAADKIEA 315

                         330       340       350
                  ....*....|....*....|....*....|....
gi 492987468  323 AVSKALNSGYLTGELLSSDKrseAKSTAEMGDFI 356
Cdd:pfam00180 316 AVLKVLESGIRTGDLAGSAT---YVSTSEFGEAV 346
PLN02329 PLN02329
3-isopropylmalate dehydrogenase
 3-364 2.00e-109

3-isopropylmalate dehydrogenase


Pssm-ID: 215188  Cd Length: 409  Bit Score: 325.87  E-value: 2.00e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468   3 YQVAVLAGDGIGPEVMAEARKVLREVEARFDLNIEYTQYDVGGIAIDNHGCPLPDATLKGCEAADAILFGSVGGPKWEKL 82
Cdd:PLN02329  47 YNIALLPGDGIGPEVISVAKNVLQKAGSLEGLEFDFQEMPVGGAALDLVGVPLPEETFTAAKQSDAILLGAIGGYKWDKN 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468  83 PPNEQPERGaLLPLRGHFELFCNLRPAKLHDGLEHMSPLRSDIsARGFDVLCVRELTGGIYFGKPKG-RQGEGENEEAFD 161
Cdd:PLN02329 127 EKHLRPEMA-LFYLRRDLKVFANLRPATVLPQLVDASTLKKEV-AEGVDMMIVRELTGGIYFGEPRGiTINENGEEVGVS 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 162 TMRYSRREISRIARIAFEAARGRRKKVTSVDKANVLACSVLWRQVVEEVAVDFPDVELEHIYIDNATMQLLRRPDEFDVM 241
Cdd:PLN02329 205 TEIYAAHEIDRIARVAFETARKRRGKLCSVDKANVLDASILWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQFDTI 284

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 242 LCSNLFGDILSDEIAMLTGSMGLLSSASMNSSGFGLFEPAGGSAPDIAGKGIANPVAQILSAALMLRHSLKQEEAASAIE 321
Cdd:PLN02329 285 VTNNIFGDILSDEASMITGSIGMLPSASLGESGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEEKAAKRIE 364

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 492987468 322 RAVSKALNSGYLTGELLSSDKRseAKSTAEMGDFIANAIKEGV 364
Cdd:PLN02329 365 DAVVDALNKGFRTGDIYSPGNK--LVGCKEMGEEVLKSVDSKV 405
PRK03437 PRK03437
3-isopropylmalate dehydrogenase; Provisional
 1-360 3.37e-99

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 179579  Cd Length: 344  Bit Score: 297.61  E-value: 3.37e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468   1 MSYQVAVLAGDGIGPEVMAEARKVLREVEARfDLNIEYTQYDVGGIAIDNHGCPLPDATLKGCEAADAILFGSVGGPKwe 80
Cdd:PRK03437   3 KTMKLAVIPGDGIGPEVVAEALKVLDAVAAG-GPGVETTEYDLGARRYLRTGETLPDSVLAELRQHDAILLGAIGDPS-- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468  81 kLPPNEQpERGALLPLRGHFELFCNLRPAKLHDGLEhmSPLRS--DIsargfDVLCVRELTGGIYFGK----PKGRQGEG 154
Cdd:PRK03437  80 -VPSGVL-ERGLLLKLRFALDHYVNLRPSKLYPGVT--SPLAGpgDI-----DFVVVREGTEGPYTGNggalRVGTPHEV 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 155 ENEEAFDTmrysRREISRIARIAFEAARGR-RKKVTSVDKANVL--ACSvLWRQVVEEVAVDFPDVELEHIYIDNATMQL 231
Cdd:PRK03437 151 ATEVSVNT----AFGVERVVRDAFERAQKRpRKHLTLVHKTNVLtfAGD-LWQRTVDEVAAEYPDVTVDYQHVDAATIFM 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 232 LRRPDEFDVMLCSNLFGDILSDEIAMLTGSMGLLSSASMNSSGFG--LFEPAGGSAPDIAGKGIANPVAQILSAALMLRH 309
Cdd:PRK03437 226 VTDPSRFDVIVTDNLFGDIITDLAAAVTGGIGLAASGNINPTGTNpsMFEPVHGSAPDIAGQGIADPTAAILSVALLLDH 305

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 492987468 310 sLKQEEAASAIERAVSKALnsgyltgellsSDKRSEAKSTAEMGDFIANAI 360
Cdd:PRK03437 306 -LGEEDAAARIEAAVEADL-----------AERGKMGRSTAEVGDRIAARL 344
TTC TIGR02089
tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+) ...
 3-360 3.98e-90

tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+)-tartrate as well as a D-malate. These enzymes are closely related to the 3-isopropylmalate and isohomocitrate dehydrogenases found in TIGR00169 and TIGR02088, respectively. [Energy metabolism, Other]


Pssm-ID: 273963  Cd Length: 352  Bit Score: 274.79  E-value: 3.98e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468    3 YQVAVLAGDGIGPEVMAEARKVLREVEARF-DLNIEYTQYDVGGIAIDNHGCPLPDATLKGCEAADAILFGSVGgpkWEK 81
Cdd:TIGR02089   4 YRIAAIPGDGIGKEVVAAALQVLEAAAKRHgGFSLHFTEFPWSCDYYKEHGKMMPEDGLEKLKKFDAIFLGAVG---WPA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468   82 LPPNEQPERGALLPLRGHFELFCNLRPAKLHDGLEhmSPLRSDiSARGFDVLCVRELTGGIYFGKpKGRQGEGENEE-AF 160
Cdd:TIGR02089  81 LVPDHISLWGLLLKIRREFDQYANVRPAKLLPGVT--SPLRNC-GPGDFDFVVVRENSEGEYSGV-GGRIHRGTDEEvAT 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468  161 DTMRYSRREISRIARIAFEAARGRRKKVTSVDKANVLACS-VLWRQVVEEVAVDFPDVELEHIYIDNATMQLLRRPDEFD 239
Cdd:TIGR02089 157 QNAIFTRKGVERIMRFAFELAQKRRKHLTSATKSNGIRHSmPFWDEVFAEVAAEYPDVEWDSYHIDALAARFVLKPETFD 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468  240 VMLCSNLFGDILSDEIAMLTGSMGLLSSASMNSSGF--GLFEPAGGSAPDIAGKGIANPVAQILSAALMLRHsLKQEEAA 317
Cdd:TIGR02089 237 VIVASNLFGDILSDLGAALMGSLGVAPSANINPEGKfpSMFEPVHGSAPDIAGKGIANPIGAIWTAAMMLEH-LGEKEAG 315

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 492987468  318 SAIERAVSKALNSGYLTGELLSSDKrseaksTAEMGDFIANAI 360
Cdd:TIGR02089 316 AKIMDAIERVTAAGILTPDVGGKAT------TSEVTEAVCNAL 352
LEU3_arch TIGR02088
isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal ...
 5-357 1.98e-85

isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal decarboxylating dehydrogenases which include the leucine biosynthesis enzyme 3-isopropylmalate dehydrogenase (LeuB, LEU3) and the methanogenic cofactor CoB biosynthesis enzyme isohomocitrate dehydrogenase (AksF). Both of these have been characterized in Methanococcus janaschii. Non-methanogenic archaea have only one hit to this model and presumably this is LeuB, although phylogenetic trees cannot establish which gene is which in the methanogens. The AksF gene is capable of acting on isohomocitrate, iso(homo)2-citrate and iso(homo)3-citrate in the successive elongation cycles of coenzyme B (7-mercaptoheptanoyl-threonine phosphate). This family is closely related to both the LeuB genes found in TIGR00169 and the mitochondrial eukaryotic isocitrate dehydratases found in TIGR00175. All of these are included within the broader subfamily model, pfam00180.


Pssm-ID: 273962  Cd Length: 322  Bit Score: 261.62  E-value: 1.98e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468    5 VAVLAGDGIGPEVMAEARKVLreveARFDLNIEYTQYDVGGIAIDNHGCPLPDATLKGCEAADAILFGSVGGPKweklPP 84
Cdd:TIGR02088   1 VAVIPGDGIGPEVIEAAIRIL----NKLGLEIEFIEFEAGDEALKKYGSALPEDTLEEIRKADAILFGAVTTPA----NP 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468   85 NEqpeRGALLPLRGHFELFCNLRPAKLHDGLEhmsplrsDISARGFDVLCVRELTGGIYFGKpkgrqGEGENEEAFDTMR 164
Cdd:TIGR02088  73 GY---KSVIVTLRKELDLYANVRPAKSLPGIP-------DLYPNGKDIVIVRENTEGLYAGF-----EFGFSDRAIAIRV 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468  165 YSRREISRIARIAFEAARGRRKKVTSVDKANVL-ACSVLWRQVVEEVAVDFpDVELEHIYIDNATMQLLRRPDEFDVMLC 243
Cdd:TIGR02088 138 ITREGSERIARFAFNLAKERNRKVTCVHKANVLkGTDGLFREVCREIAKRY-GVEYRDMYVDSAAMNLVKDPWRFDVIVT 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468  244 SNLFGDILSDEIAMLTGSMGLLSSASMNSSgFGLFEPAGGSAPDIAGKGIANPVAQILSAALMLRHSLKQEEAAsAIERA 323
Cdd:TIGR02088 217 TNMFGDILSDLASALAGSLGLAPSANIGDR-KALFEPVHGSAPDIAGKGIANPTAAILSVAMMLDYLGELEKGK-LVWEA 294

                         330       340       350
                  ....*....|....*....|....*....|....
gi 492987468  324 VSKALNSGYLTGELLSSDKrseaksTAEMGDFIA 357
Cdd:TIGR02088 295 VEYYIIEGKKTPDLGGTAK------TKEVGDEIA 322
AksF2_Meth NF040626
homoisocitrate dehydrogenase;
3-362 5.45e-82

homoisocitrate dehydrogenase;


Pssm-ID: 468598  Cd Length: 332  Bit Score: 253.12  E-value: 5.45e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468   3 YQVAVLAGDGIGPEVMAEARKVLReveaRFDLNIEYTQYDVGGIAIDNHGCPLPDATLKGCEAADAILFGSVGGPKWEKL 82
Cdd:NF040626   2 YKITVIPGDGIGKEVMEAALYVLD----ALDLNFDFIEAEAGRECFKKNGTTIPEETIKIAKKSDATLFGAVTSTPGQKS 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468  83 PpneqpergaLLPLRGHFELFCNLRPAKLHDGLEhmsPLRSDIsargfDVLCVRELTGGIYfgkpKGRQGEGENEEAFDT 162
Cdd:NF040626  78 P---------IITLRKELDLYANLRPIKSYEGIN---CLFKDL-----DFLIVRENTEGLY----SGLEEEYTEEKAIAE 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 163 MRYSRREISRIARIAFEAARGR-RKKVTSVDKANVLA-CSVLWRQVVEEVAVDFPDVELEHIYIDNATMQLLRRPDEFDV 240
Cdd:NF040626 137 RVITRKASERICKFAFEYAIKLgRKKVTAVHKANVLKkTDGIFKDTFYKVAKDYPQIETEDYYVDATAMYLITKPQDFDV 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 241 MLCSNLFGDILSDEIAMLTGSMGLLSSASMNSSGfGLFEPAGGSAPDIAGKGIANPVAQILSAALMLRHsLKQEEAASAI 320
Cdd:NF040626 217 IVTTNLFGDILSDEAAGLVGGLGLAPSANIGDKN-GLFEPVHGSAPDIAGKNIANPIAMILSASMMLDY-LGETYEANKL 294

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 492987468 321 ERAVSKALNSgyltGELLSSDKRSEAKsTAEMgdfiANAIKE 362
Cdd:NF040626 295 ENALEKVLRE----GKVVTPDLGGNAK-TMEM----ANEIKK 327
PRK08194 PRK08194
tartrate dehydrogenase; Provisional
 5-362 1.24e-80

tartrate dehydrogenase; Provisional


Pssm-ID: 181281  Cd Length: 352  Bit Score: 250.41  E-value: 1.24e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468   5 VAVLAGDGIGPEVMAEARKVLREV-EARFDLNIEYTQYDVGGIAIDNHGCPLPDATLKGCEAADAILFGSVGGPKwekLP 83
Cdd:PRK08194   6 IAVIPGDGVGKEVVPAAVRVLKAVaEVHGGLKFEFTEFPWSCEYYLEHGEMMPEDGLEQLKQFDAIFLGAVGNPK---LV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468  84 PNEQPERGALLPLRGHFELFCNLRPAKLHDGLEhmSPLRSdisARGFDVLCVRELTGGIYfGKPKGRQGEGENEEAFDTM 163
Cdd:PRK08194  83 PDHISLWGLLIKIRREFEQVINIRPAKQLRGIK--SPLAN---PKDFDLLVVRENSEGEY-SEVGGRIHRGEDEIAIQNA 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 164 RYSRREISRIARIAFEAARGRRKKVTSVDKANVLACSV-LWRQVVEEVAVDFPDVELEHIYIDNATMQLLRRPDEFDVML 242
Cdd:PRK08194 157 VFTRKGTERAMRYAFELAAKRRKHVTSATKSNGIVHSMpFWDEVFQEVGKDYPEIETDSQHIDALAAFFVTRPEEFDVIV 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 243 CSNLFGDILSDEIAMLTGSMGLLSSASMNSSGF--GLFEPAGGSAPDIAGKGIANPVAQILSAALMLRHsLKQEEAASAI 320
Cdd:PRK08194 237 ASNLFGDILTDIGAAIMGSIGIAPAANINVNGKypSMFEPVHGSAPDIAGKGIANPIGQIWTAKLMLDH-FGEEELGSHL 315

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 492987468 321 ERAVSKALNSGYLTGELlssdkrSEAKSTAEMGDFIANAIKE 362
Cdd:PRK08194 316 LDVIEDVTEDGIKTPDI------GGRATTDEVTDEIISRLKK 351
PRK14025 PRK14025
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
 2-360 7.50e-80

multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional


Pssm-ID: 184462  Cd Length: 330  Bit Score: 247.35  E-value: 7.50e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468   2 SYQVAVLAGDGIGPEVMAEARKVLREVearfDLNIEYTQYDVGGIAIDNHGCPLPDATLKGCEAADAILFGSVGgpkwek 81
Cdd:PRK14025   1 MHKICVIEGDGIGKEVVPAALHVLEAT----GLPFEFVYAEAGDEVFEKTGKALPEETIEAAKEADAVLFGAAG------ 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468  82 lppneQPERGALLPLRGHFELFCNLRPAKLHDGLEHMSPlrsdisarGFDVLCVRELTGGIYfgkpKGRQGEGENEEAFD 161
Cdd:PRK14025  71 -----ETAADVIVKLRRILDTYANVRPVKSYKGVKCLYP--------DIDYVIVRENTEGLY----KGIEAEIADGVTVA 133

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 162 TMRYSRREISRIARIAFEAAR-----GRRKKVTSVDKANVLACSV-LWRQVVEEVAVDFPDVELEHIYIDNATMQLLRRP 235
Cdd:PRK14025 134 TRVITRKASERIFRFAFEMAKrrkkmGKEGKVTCAHKANVLKKTDgLFKKTFYEVAKEYPDIKAEDYYVDAMNMYIITRP 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 236 DEFDVMLCSNLFGDILSDEIAMLTGSMGLLSSASMNSSgFGLFEPAGGSAPDIAGKGIANPVAQILSAALMLRHsLKQEE 315
Cdd:PRK14025 214 QTFDVVVTSNLFGDILSDGAAGLVGGLGLAPSANIGDK-YGLFEPVHGSAPDIAGKGIANPTATILTAVLMLRH-LGENE 291

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 492987468 316 AASAIERAVSKALNSGYLTGELLSSdkrseaKSTAEMGDFIANAI 360
Cdd:PRK14025 292 EADKVEKALEEVLALGLTTPDLGGN------LSTMEMAEEVAKRV 330
PRK08997 PRK08997
isocitrate dehydrogenase; Provisional
 1-337 4.96e-71

isocitrate dehydrogenase; Provisional


Pssm-ID: 181606  Cd Length: 334  Bit Score: 224.98  E-value: 4.96e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468   1 MSYQVAVLAGDGIGPEVMAEARKVLREVEArfDLNIEYTqyDVGGIAIDNHGCPLPDATLKGCEAADAILFGSVGGPKWE 80
Cdd:PRK08997   1 MKQTITVIPGDGIGPSIIDATLKILDKLGC--DFEYEFA--DAGLTALEKHGELLPQRTLDLIEKNKIALKGPLTTPVGE 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468  81 KLPPNEqpergalLPLRGHFELFCNLRPAKLHDGLEHmsplRSDisarGFDVLCVRELTGGIYFGKpkGRQGEGENEEAF 160
Cdd:PRK08997  77 GFTSIN-------VTLRKKFDLYANVRPVLSFPGTKA----RYD----NIDIITVRENTEGMYSGE--GQTVSEDGETAE 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 161 DTMRYSRREISRIARIAFEAARGR-RKKVTSVDKANVL-ACSVLWRQVVEEVAVDFPDVELEHIYIDNATMQLLRRPDEF 238
Cdd:PRK08997 140 ATSIITRKGAERIVRFAYELARKEgRKKVTAVHKANIMkSTSGLFLKVAREVALRYPDIEFEEMIVDATCMQLVMNPEQF 219

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 239 DVMLCSNLFGDILSDEIAMLTGSMGLLSSASMNSSGfGLFEPAGGSAPDIAGKGIANPVAQILSAALMLRHsLKQEEAAS 318
Cdd:PRK08997 220 DVIVTTNLFGDILSDLCAGLVGGLGMAPGANIGRDA-AIFEAVHGSAPDIAGKNLANPTSVILAAIQMLEY-LGMPDKAE 297

                        330       340
                 ....*....|....*....|
gi 492987468 319 AIERAVSKALNSG-YLTGEL 337
Cdd:PRK08997 298 RIRKAIVAVIEAGdRTTRDL 317
AksF_Meth NF040619
homoisocitrate dehydrogenase;
3-345 6.63e-71

homoisocitrate dehydrogenase;


Pssm-ID: 468591  Cd Length: 332  Bit Score: 224.64  E-value: 6.63e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468   3 YQVAVLAGDGIGPEVMAEARKVLREVEarfdlNIEYTQYDVGGIAIDNHGCPLPDATLKGCEAADAILFGSVGGPKwekl 82
Cdd:NF040619   2 PKICVIEGDGIGKEVIPETVRVLKELG-----DFEFIKGEAGLECFKKYGDAIPEETIEKAKECDAILFGAVTTPK---- 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468  83 pPNE---QPERGALLPLRGHFELFCNLRPaklhdglehMSPLRSDISARGFDVLCVRELTGGIYFGKPKGRQgegENEEA 159
Cdd:NF040619  73 -PTElknKNYKSPILTLRKELDLYANVRP---------INNFGDGQDVKNIDFVIIRENTEGLYVGREYYDE---ENEIA 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 160 FDTMRYSRREISRIARIAFE-AARGRRKKVTSVDKANVLACSV-LWRQVVEEVAVDF--PDVELEHIYIDNATMQLLRRP 235
Cdd:NF040619 140 IAERIISKKGSERIIKFAFEyAKKNNRKKVSCIHKANVLRVTDgLFLEIFNEIKKKYknFNIEADDYLVDATAMYLIKNP 219

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 236 DEFDVMLCSNLFGDILSDEIAMLTGSMGLLSSASMNSSgFGLFEPAGGSAPDIAGKGIANPVAQILSAALMLRHsLKQEE 315
Cdd:NF040619 220 EMFDVIVTTNLFGDILSDEASGLIGGLGLAPSANIGDK-KGLFEPVHGSAPDIAGKGIANPIATILSAAMMLDY-LGMKE 297

                        330       340       350
                 ....*....|....*....|....*....|
gi 492987468 316 AASAIERAVSKALNSGYLTGELLSSDKRSE 345
Cdd:NF040619 298 KGDLIREAVKKCLENGKVTPDLGGNLKTKE 327
PRK09222 PRK09222
NADP-dependent isocitrate dehydrogenase;
1-351 1.17e-56

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236416 [Multi-domain]  Cd Length: 482  Bit Score: 191.64  E-value: 1.17e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468   1 MSYQVAVLAGDGIGPEVMAEARKVLREVEARFDL-NIE-----YTQYDVGGIAidnhgcplPDAtlkgceaadailfgsv 74
Cdd:PRK09222   3 EKTPITVAYGDGIGPEIMEAVLKILEAAGAPLEIeTIEigekvYKKGWTSGIS--------PSA---------------- 58

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468  75 ggpkWEKL--------PPNEQPERG----ALLPLRGHFELFCNLRPAK-LHDGLEHMSPlrsdisarGFDVLCVRE---- 137
Cdd:PRK09222  59 ----WESIrrtkvllkAPITTPQGGgyksLNVTLRKTLGLYANVRPCVsYHPFVETKHP--------NLDVVIIREneed 126

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 138 LTGGIYFgkpkgRQGEgeneeafDTMR----YSRREISRIARIAFEAARGR-RKKVTSVDKANVLACSV-LWRQVVEEVA 211
Cdd:PRK09222 127 LYAGIEH-----RQTP-------DVYQclklISRPGSEKIIRYAFEYARANgRKKVTCLTKDNIMKLTDgLFHKVFDEIA 194

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 212 VDFPDVELEHIYIDNATMQLLRRPDEFDVMLCSNLFGDILSDEIAMLTGSMGLLSSASMNSSGfGLFEPAGGSAPDIAGK 291
Cdd:PRK09222 195 KEYPDIEAEHYIVDIGAARLATNPENFDVIVTPNLYGDILSDIAAEISGSVGLAGSANIGEEY-AMFEAVHGSAPDIAGK 273

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 492987468 292 GIANPVAQILSAALMLRHsLKQEEAASAIERAVSKALNSGYLTGElLSSDKRSEAK-STAE 351
Cdd:PRK09222 274 NIANPSGLLNAAVMMLVH-IGQFDIAELIENAWLKTLEDGIHTAD-IYNEGVSKKKvGTKE 332
Icd COG0538
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
 10-362 7.39e-44

Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440304  Cd Length: 409  Bit Score: 156.04  E-value: 7.39e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468  10 GDGIGPEVMAEARKVLRE-VEARF--DLNIEYTQYDVGGIAIDNHGCPLPDatlkgcEAADAILFGSVG--GPkwekL-P 83
Cdd:COG0538   26 GDGIGPEITRAIWKVIDAaVEKAYggKRDIEWKEVDAGEKARDETGDWLPD------ETAEAIKEYGVGikGP----LtT 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468  84 PNEQPER---GALlplRGHFELFCNLRPAKLHDGLEhmSPLRS----DIsargfdvlCV-RELTGGIYFG---KPKGRQG 152
Cdd:COG0538   96 PVGGGWRslnVTI---RQILDLYVCRRPVRYFKGVP--SPVKHpekvDI--------VIfRENTEDIYAGiewKAGSPEA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 153 E-----GENEEAFDTMR-----------YSRREISRIARIAFE-AARGRRKKVTSVDKANVL-----AcsvlWRQVVEEV 210
Cdd:COG0538  163 LkliffLEDEMGVTVIRfpedsgigikpVSDEGTERLVRAAIQyALDNKRKSVTLVHKGNIMkftegA----FKDWGYEV 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 211 AVD-FPD-------------------VELEHIYIDNATMQLLRRPDEFDVMLCSNLFGDILSDEIAMLTGSMGLLSSASM 270
Cdd:COG0538  239 AEEeFGDkfitegpwekykgpkpagkIVYKDRIADDMLQQILLRPGEYDVIATKNLNGDYISDALAAQVGGLGIAPGANI 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 271 NSSGFGLFEPAGGSAPDIAGKGIANPVAQILSAALMLRHsLKQEEAASAIERAVSKALNSGYLTGEL--LSSDKRseAKS 348
Cdd:COG0538  319 GDDGGAEFEATHGTAPKYAGKDSTNPGSLILSGTMMLRH-RGWLEAADLIEKAVEKTIESGKVTYDLarLMEGAT--ELS 395

                        410
                 ....*....|....
gi 492987468 349 TAEMGDFIANAIKE 362
Cdd:COG0538  396 TSEFGDAIIENLDK 409
PLN00118 PLN00118
isocitrate dehydrogenase (NAD+)
 10-345 2.82e-43

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215062  Cd Length: 372  Bit Score: 153.88  E-value: 2.82e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468  10 GDGIGPEVMAEARKVLREVEARfdlnIEYTQYDVGGiAIDnhgcPLPDATLKgCEAADAILFGSVG--GPKwekLPPNEQ 87
Cdd:PLN00118  49 GDGIGPEIAESVKQVFTAAGVP----IEWEEHYVGT-TVD----PRTGSFLT-WESLESVRRNKVGlkGPM---ATPIGK 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468  88 PERGALLPLRGHFELFCNLRPAKLHDGLEhmspLRSDisarGFDVLCVRELTGGIYFG-KPKGRQGEGENEEAFdtmryS 166
Cdd:PLN00118 116 GHRSLNLTLRKELGLYANVRPCYSLPGYK----TRYD----DVDLVTIRENTEGEYSGlEHQVVRGVVESLKII-----T 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 167 RREISRIARIAFEAARGR-RKKVTSVDKANVL-ACSVLWRQVVEEVAVDFPDVELEHIYIDNATMQLLRRPDEFDVMLCS 244
Cdd:PLN00118 183 RQASLRVAEYAFHYAKTHgRKRVSAIHKANIMkKTDGLFLKCCREVAEKYPEIVYEEVIIDNCCMMLVKNPALFDVLVMP 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 245 NLFGDILSDEIAMLTGSMGLLSSASMNSSGFGLFEPAGGSAPDIAGKGIANPVAQILSAALMLRHsLKQEEAASAIERAV 324
Cdd:PLN00118 263 NLYGDIISDLCAGLIGGLGLTPSCNIGENGLALAEAVHGSAPDIAGKNLANPTALLLSAVMMLRH-LKLNEQAEQIHNAI 341

                        330       340
                 ....*....|....*....|..
gi 492987468 325 SKALNSG-YLTGELLSSDKRSE 345
Cdd:PLN00118 342 LNTIAEGkYRTADLGGSSTTTD 363
PRK06451 PRK06451
NADP-dependent isocitrate dehydrogenase;
10-361 3.22e-35

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 235803  Cd Length: 412  Bit Score: 133.03  E-value: 3.22e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468  10 GDGIGPEVMAEARKVL-REVEARF--DLNIEYTQYDVGGIAIDNHGCPLPDATLKGCEAADAILFGSVGGP---KWEKLP 83
Cdd:PRK06451  31 GDGIGPEITHAAMKVInKAVEKAYgsDREIKWVEVLAGDKAEKLTGNRFPKESEELIEKYRVLLKGPLETPigkGWKSIN 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468  84 pneqpergalLPLRGHFELFCNLRPAKLHDGLEhmSPLRsdiSARGFDVLCVRELTGGIYfgkpKGRQGEGENEEAFDTM 163
Cdd:PRK06451 111 ----------VAIRLMLDLYANIRPVKYIPGIE--SPLK---NPEKIDLIIFRENTDDLY----RGIEYPYDSEEAKKIR 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 164 RYSRREI--------------------SRIARIAFE-AARGRRKKVTSVDKANVLACSV-LWRQVVEEVAV-DFPD---- 216
Cdd:PRK06451 172 DFLRKELgveveddtgigikliskfktQRIARMAIKyAIDHKRKKVTIMHKGNVMKYTEgAFREWAYEVALkEFRDyvvt 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 217 ----------------VELEHIYIDNATMQLLRRPDEFDVMLCSNLFGDILSDEIAMLTGSMGLLSSASMNSSGfGLFEP 280
Cdd:PRK06451 252 eeevtknyngvppsgkVIINDRIADNMFQQIIIRPDEYDIILAPNVNGDYISDAAGALVGNIGMLGGANIGDTG-GMFEA 330

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 281 AGGSAPDIAGKGIANPVAQILSAALMLRHsLKQEEAASAIERAVSKALNSGYLTGElLSSDKRSEAKSTAEMGDFIANAI 360
Cdd:PRK06451 331 IHGTAPKYAGKNVANPTGIIKGGELMLRF-MGWDKAADLIDKAIMESIKQKKVTQD-LARFMGVRALSTTEYTDELISII 408


                 .
gi 492987468 361 K 361
Cdd:PRK06451 409 D 409
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 5-337 1.09e-30

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 119.97  E-value: 1.09e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468   5 VAVLAGDGIGPEVMAEARKVLREVEArfdlNIEYTQYDVGGIAIDnhgcpLPDATLKGCEAADAILFGSVGGPKWEKLPP 84
Cdd:PLN00123  33 VTLIPGDGIGPLVTGAVEQVMEAMHA----PVYFERYEVHGDMKK-----VPEEVLESIRRNKVCLKGGLATPVGGGVSS 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468  85 -NEQpergallpLRGHFELFCNLRPAKLHDGLehmsPLRSDisarGFDVLCVRELTGGIYFGKpkgrqgegENE------ 157
Cdd:PLN00123 104 lNVQ--------LRKELDLFASLVNCFNLPGL----PTRHE----NVDIVVIRENTEGEYSGL--------EHEvvpgvv 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 158 EAFDTMRYSRREisRIARIAFEAAR-GRRKKVTSVDKANVLACSV-LWRQVVEEVAVDFPDVELEHIYIDNATMQLLRRP 235
Cdd:PLN00123 160 ESLKVITKFCSE--RIAKYAFEYAYlNNRKKVTAVHKANIMKLADgLFLESCREVAKKYPGIKYNEIIVDNCCMQLVSKP 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 236 DEFDVMLCSNLFGDILSDEIAMLTGSMGLLSSASMnSSGFGLFEpAGGSA-----PDIAGKGIANPVAQILSAALMLRHs 310
Cdd:PLN00123 238 EQFDVMVTPNLYGNLVANTAAGIAGGTGVMPGGNV-GADHAVFE-QGASAgnvgnEKLVEQKKANPVALLLSSAMMLRH- 314

                        330       340
                 ....*....|....*....|....*...
gi 492987468 311 LKQEEAASAIERAVSKALNSG-YLTGEL 337
Cdd:PLN00123 315 LQFPSFADRLETAVKRVIAEGkYRTKDL 342
PRK07006 PRK07006
isocitrate dehydrogenase; Reviewed
 10-334 8.95e-21

isocitrate dehydrogenase; Reviewed


Pssm-ID: 180792  Cd Length: 409  Bit Score: 92.82  E-value: 8.95e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468  10 GDGIGPEVMAEARKVLRE-VEARF--DLNIEYTQYDVGGIAIDNHGCP--LPDATLKGC-EAADAI---LFGSVGGPKwe 80
Cdd:PRK07006  27 GDGIGPDITPAMLKVVDAaVEKAYkgERKISWMEIYAGEKATKVYGEDvwLPEETLDLIrEYRVAIkgpLTTPVGGGI-- 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468  81 klppneqpeRGALLPLRGHFELFCNLRPAKLHDGLEhmSPLRSdisARGFDVLCVRELTGGIYfgkpKGRQGEGENEEAF 160
Cdd:PRK07006 105 ---------RSLNVALRQELDLYVCLRPVRYFKGVP--SPVKR---PEDTDMVIFRENSEDIY----AGIEWKAGSAEAK 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 161 DTMRYSRREI-----------------------SRIARIAFE-AARGRRKKVTSVDKANVLACSV-LWRQVVEEVAV-DF 214
Cdd:PRK07006 167 KVIKFLQEEMgvkkirfpetsgigikpvseegtERLVRAAIEyAIDNDRKSVTLVHKGNIMKFTEgAFKDWGYQLAEeEF 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 215 PDvEL----EHIYIDNAT----------------MQLLRRPDEFDVMLCSNLFGDILSDEIAMLTGSMGLLSSASMNSsG 274
Cdd:PRK07006 247 GD-ELidggPWDKIKNPEtgkeiivkdsiadaflQQILLRPAEYDVIATMNLNGDYISDALAAQVGGIGIAPGANIND-G 324

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 275 FGLFEPAGGSAPDIAGKGIANPVAQILSAALMLRHsLKQEEAASAIERAVSKALNSGYLT 334
Cdd:PRK07006 325 HAIFEATHGTAPKYAGLDKVNPGSVILSAEMMLRH-MGWTEAADLIIKSMEKTIASKTVT 383
PRK07362 PRK07362
NADP-dependent isocitrate dehydrogenase;
225-337 1.18e-10

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 180944  Cd Length: 474  Bit Score: 62.42  E-value: 1.18e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 225 DNATMQLLRRPDEFDVMLCSNLFGDILSDEIAMLTGSMGLLSSASMNSSGfGLFEPAGGSAPDIAGKGIANPVAQILSAA 304
Cdd:PRK07362 340 DSIFQQIQTRPQEYSILATLNLNGDYISDAAAAIVGGLGMAPGANIGDNA-AIFEATHGTAPKHAGLDRINPGSVILSGV 418

                         90       100       110
                 ....*....|....*....|....*....|...
gi 492987468 305 LMLRHsLKQEEAASAIERAVSKALNSGYLTGEL 337
Cdd:PRK07362 419 MMLEY-LGWQEAADLITKGLSAAIANKQVTYDL 450
PTZ00435 PTZ00435
isocitrate dehydrogenase; Provisional
 208-361 2.85e-05

isocitrate dehydrogenase; Provisional


Pssm-ID: 240417  Cd Length: 413  Bit Score: 45.75  E-value: 2.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 208 EEVAVDFPDVEL--EHIYIDNATMQLLRRPDEFdVMLCSNLFGDILSDEIAMLTGSMGLLSSASMNSSGFG-LFEPAGGS 284
Cdd:PTZ00435 234 EEYKAKFEKAGLwyEHRLIDDMVAQAIKSEGGF-VWACKNYDGDVQSDIVAQGYGSLGLMTSVLVCPDGKTvEAEAAHGT 312

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 285 ------APDIAGKGIANPVAQILSAALMLRHSLK----QE--EAASAIERAVSKALNSGYLTGEL------LSSDKRSEA 346
Cdd:PTZ00435 313 vtrhyrQHQKGKETSTNSIASIFAWTRGLAHRAKldnnQElvKFCQALERSCIETIEAGFMTKDLaicvhgSSKVTRSDY 392

                        170
                 ....*....|....*
gi 492987468 347 KSTAEMGDFIANAIK 361
Cdd:PTZ00435 393 LNTEEFIDKVAEKLK 407
PLN03065 PLN03065
isocitrate dehydrogenase (NADP+); Provisional
 203-337 1.33e-04

isocitrate dehydrogenase (NADP+); Provisional


Pssm-ID: 178617 [Multi-domain]  Cd Length: 483  Bit Score: 43.72  E-value: 1.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 203 WRQVVEEVAVDFpdvelEHIYIDNATMQLLRRPDEFdVMLCSNLFGDILSDEIAMLTGSMGLLSSASMNSSGFGL-FEPA 281
Cdd:PLN03065 304 WKQKFEEHSIWY-----EHRLIDDMVAYAVKSEGGY-VWACKNYDGDVQSDLLAQGFGSLGLMTSVLLSSDGKTLeAEAA 377

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 492987468 282 GGSAP---DIAGKGI---ANPVAQILSAALMLRHSLKQEEAASAI------ERAVSKALNSGYLTGEL 337
Cdd:PLN03065 378 HGTVTrhfRLHQKGQetsTNSIASIFAWTRGLEHRAKLDKNEELLdfvhklESACIETVESGKMTKDL 445
PRK08299 PRK08299
NADP-dependent isocitrate dehydrogenase;
217-337 2.04e-03

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236226  Cd Length: 402  Bit Score: 39.84  E-value: 2.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492987468 217 VELEHIYIDNATMQLLRRPDEFdVMLCSNLFGDILSDEIAMLTGSMGLLSSASMNSSGFGL-FEPAGGSAPD-----IAG 290
Cdd:PRK08299 242 ITYEHRLIDDMVASALKWEGGY-VWACKNYDGDVQSDTVAQGFGSLGLMTSVLMTPDGKTVeAEAAHGTVTRhyrqhQKG 320

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 492987468 291 KGIA-NPVAQIL--SAALMLRHSLKQEEA----ASAIERAVSKALNSGYLTGEL 337
Cdd:PRK08299 321 EETStNPIASIFawTRGLAHRGKLDGNPElvkfADTLEKVCIETVESGFMTKDL 374
PLN00096 PLN00096
isocitrate dehydrogenase (NADP+); Provisional
 215-288 2.44e-03

isocitrate dehydrogenase (NADP+); Provisional


Pssm-ID: 177715  Cd Length: 393  Bit Score: 39.63  E-value: 2.44e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 492987468 215 PDVELEHIYIDNATMQLLRRPDEFDVMLCSNLFGDILSDEIAMLTGSMGLLSS----ASMNSSGFGLFEPAGGSAPDI 288
Cdd:PLN00096 235 SGDELVHLLSDAATMKLVVWTDGGFGMAAHNYDGDVLTDELAQVHKSPGFITSnlvgVDENGTLIKEFEASHGTVTDM 312
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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