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Conserved domains on  [gi|491675627|ref|WP_005531769|]
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ABC transporter permease [Vibrio campbellii]

Protein Classification

ABC transporter permease( domain architecture ID 11439449)

ABC transporter permease is the transmembrane (TM) subunit in a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter which generally binds a type 2 PBP; similar to the permease subunit of ABC-type dipeptide/oligopeptide/nickel transport systems

Gene Ontology:  GO:0140359|GO:0042626
PubMed:  25750732|24638992
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DppC COG1173
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 1-303 6.75e-86

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


:

Pssm-ID: 440786 [Multi-domain]  Cd Length: 275  Bit Score: 260.05  E-value: 6.75e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491675627   1 MKELFKLILGNAFARVGLAIISVFIFVAVAAPLITQHAPDKRtgnpheypgfvvkqaqnnpdgwvaknladDRRSLLMSK 80
Cdd:COG1173    5 WRRAWRRLRRNPLAVIGLVILLLLVLLALFAPLLAPYDPTAQ-----------------------------DLAARLQPP 55

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491675627  81 KADHVLGTSRMGRDIWSQVAYGARVSLGVGFGAGIIVCFLATVIGISAGYFGGRVDDVLSAAMNIMLVIPQLPLLFVLAA 160
Cdd:COG1173   56 SAAHWLGTDQLGRDVLSRLLYGARISLLVGLLAVLIALVIGVLLGLLAGYFGGWVDAVLMRLVDVLLAFPSLLLAIALVA 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491675627 161 FIGeAGPLTIALIIAGTSWAWGARVVRAQTMALREKEFVKAAEVLGESSMRIIFVEILPNLIPIVGASFIGSVMLAINTE 240
Cdd:COG1173  136 VLG-PGLLNVILALGLTGWPGYARLVRAQVLSLREREYVEAARALGASPLRIIFRHILPNVLPPLIVQATLGIASAILAE 214

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491675627 241 AVISFLGLG-DANTISWGIMLYNVQTssaMLIGAWWEVLAPCIALTLLVTGLALLNFAVDEIAN 303
Cdd:COG1173  215 AGLSFLGLGvQPPTPSWGTMLSEGRN---YLLTAPWLALFPGLAIVLTVLAFNLLGDGLRDALD 275
 
Name Accession Description Interval E-value
DppC COG1173
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 1-303 6.75e-86

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


Pssm-ID: 440786 [Multi-domain]  Cd Length: 275  Bit Score: 260.05  E-value: 6.75e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491675627   1 MKELFKLILGNAFARVGLAIISVFIFVAVAAPLITQHAPDKRtgnpheypgfvvkqaqnnpdgwvaknladDRRSLLMSK 80
Cdd:COG1173    5 WRRAWRRLRRNPLAVIGLVILLLLVLLALFAPLLAPYDPTAQ-----------------------------DLAARLQPP 55

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491675627  81 KADHVLGTSRMGRDIWSQVAYGARVSLGVGFGAGIIVCFLATVIGISAGYFGGRVDDVLSAAMNIMLVIPQLPLLFVLAA 160
Cdd:COG1173   56 SAAHWLGTDQLGRDVLSRLLYGARISLLVGLLAVLIALVIGVLLGLLAGYFGGWVDAVLMRLVDVLLAFPSLLLAIALVA 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491675627 161 FIGeAGPLTIALIIAGTSWAWGARVVRAQTMALREKEFVKAAEVLGESSMRIIFVEILPNLIPIVGASFIGSVMLAINTE 240
Cdd:COG1173  136 VLG-PGLLNVILALGLTGWPGYARLVRAQVLSLREREYVEAARALGASPLRIIFRHILPNVLPPLIVQATLGIASAILAE 214

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491675627 241 AVISFLGLG-DANTISWGIMLYNVQTssaMLIGAWWEVLAPCIALTLLVTGLALLNFAVDEIAN 303
Cdd:COG1173  215 AGLSFLGLGvQPPTPSWGTMLSEGRN---YLLTAPWLALFPGLAIVLTVLAFNLLGDGLRDALD 275
nikC PRK10417
nickel transporter permease NikC; Provisional
 15-311 1.11e-33

nickel transporter permease NikC; Provisional


Pssm-ID: 236687 [Multi-domain]  Cd Length: 272  Bit Score: 125.17  E-value: 1.11e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491675627  15 RVGLAIISVFIFVAVAAPLITQHAPDkrtgnpheypgfvvkqaqnnpdgwvaknlADDRRSLLMSKKADHVLGTSRMGRD 94
Cdd:PRK10417   7 RLALIIIALLALIALTSQWWLPYDPQ-----------------------------AIDLPSRLLSPDAQHWLGTDHLGRD 57

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491675627  95 IWSQVAYGARVSLGVGFGAGIIVCFLATVIGISAGYFGGRVDDVLSAAMNIMLVIPQLPLLFVLAAFIGeAGPLTIALII 174
Cdd:PRK10417  58 IFSRLMAGTRVSLGSVMACLLLVLALGLVIGGSAGLLGGRVDQATMRVADMFMTFPTSILAFFMVGVLG-TGLTNVIIAI 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491675627 175 AGTSWAWGARVVRAQTMALREKEFVKAAEVLGESSMRIIFVEILPNLIP---IVGASFIGSVMLAInteAVISFLGLG-D 250
Cdd:PRK10417 137 ALSHWAWYARMVRSLVISLRQREFVLAARLSGAGHVRVFIDHLLPAVIPqllVLATLDIGHMMLHV---AGLSFLGLGvT 213

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491675627 251 ANTISWGIMLYNVQT---SSAMLIgawwevLAPCIALTLLVTGLALLNFAVDEIANPQLRSHKG 311
Cdd:PRK10417 214 APTAEWGVMINDARQyiwTQPLLM------FWPGLALFISVMAFNLLGDALRDHLDPHLVTEHA 271
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 103-273 4.86e-21

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 88.87  E-value: 4.86e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491675627 103 ARVSLGVGFGAGIIVCFLATVIGISAGYFGGRVDDVLSAAMNIMLVIPQLPLLFVLAAFIGEAGPLTI-------ALIIA 175
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGIlpglglpALILA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491675627 176 GTSWAWGARVVRAQTMALREKEFVKAAEVLGESSMRIIFVEILPNLIPIVGASFIGSVMLAINTEAVISFLGLGDANTIS 255
Cdd:cd06261   81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPG 160

                        170
                 ....*....|....*...
gi 491675627 256 WGIMLYNVQTSSAMLIGA 273
Cdd:cd06261  161 TGLLLIFAILFPGDLGVA 178
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 121-273 1.41e-13

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 68.09  E-value: 1.41e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491675627  121 ATVIGISAG-YFGGRVDDVLSAAMNIMLVIP---QLPLLFVLAAFIGEAGPLTIALIIAGTSWAWGARVVRAQTMALREK 196
Cdd:pfam00528   1 GIPLGIIAAlRRGRRLDRLLRPLIDLLQALPsfvLAILLVVIAILSILGHGILPAIILALLGWAGYARLIRRAALRSLPS 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491675627  197 EFVKAAEVLGESSMRIIFVEILPNLIPIVGASFIGSVMLAINTEAVISFLGL--GDANTISWGIMLYNVQTSSAMLIGA 273
Cdd:pfam00528  81 DLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSwpGLGLLLIEAILGYDYPEIQGPVLAA 159
 
Name Accession Description Interval E-value
DppC COG1173
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 1-303 6.75e-86

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


Pssm-ID: 440786 [Multi-domain]  Cd Length: 275  Bit Score: 260.05  E-value: 6.75e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491675627   1 MKELFKLILGNAFARVGLAIISVFIFVAVAAPLITQHAPDKRtgnpheypgfvvkqaqnnpdgwvaknladDRRSLLMSK 80
Cdd:COG1173    5 WRRAWRRLRRNPLAVIGLVILLLLVLLALFAPLLAPYDPTAQ-----------------------------DLAARLQPP 55

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491675627  81 KADHVLGTSRMGRDIWSQVAYGARVSLGVGFGAGIIVCFLATVIGISAGYFGGRVDDVLSAAMNIMLVIPQLPLLFVLAA 160
Cdd:COG1173   56 SAAHWLGTDQLGRDVLSRLLYGARISLLVGLLAVLIALVIGVLLGLLAGYFGGWVDAVLMRLVDVLLAFPSLLLAIALVA 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491675627 161 FIGeAGPLTIALIIAGTSWAWGARVVRAQTMALREKEFVKAAEVLGESSMRIIFVEILPNLIPIVGASFIGSVMLAINTE 240
Cdd:COG1173  136 VLG-PGLLNVILALGLTGWPGYARLVRAQVLSLREREYVEAARALGASPLRIIFRHILPNVLPPLIVQATLGIASAILAE 214

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491675627 241 AVISFLGLG-DANTISWGIMLYNVQTssaMLIGAWWEVLAPCIALTLLVTGLALLNFAVDEIAN 303
Cdd:COG1173  215 AGLSFLGLGvQPPTPSWGTMLSEGRN---YLLTAPWLALFPGLAIVLTVLAFNLLGDGLRDALD 275
nikC PRK10417
nickel transporter permease NikC; Provisional
 15-311 1.11e-33

nickel transporter permease NikC; Provisional


Pssm-ID: 236687 [Multi-domain]  Cd Length: 272  Bit Score: 125.17  E-value: 1.11e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491675627  15 RVGLAIISVFIFVAVAAPLITQHAPDkrtgnpheypgfvvkqaqnnpdgwvaknlADDRRSLLMSKKADHVLGTSRMGRD 94
Cdd:PRK10417   7 RLALIIIALLALIALTSQWWLPYDPQ-----------------------------AIDLPSRLLSPDAQHWLGTDHLGRD 57

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491675627  95 IWSQVAYGARVSLGVGFGAGIIVCFLATVIGISAGYFGGRVDDVLSAAMNIMLVIPQLPLLFVLAAFIGeAGPLTIALII 174
Cdd:PRK10417  58 IFSRLMAGTRVSLGSVMACLLLVLALGLVIGGSAGLLGGRVDQATMRVADMFMTFPTSILAFFMVGVLG-TGLTNVIIAI 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491675627 175 AGTSWAWGARVVRAQTMALREKEFVKAAEVLGESSMRIIFVEILPNLIP---IVGASFIGSVMLAInteAVISFLGLG-D 250
Cdd:PRK10417 137 ALSHWAWYARMVRSLVISLRQREFVLAARLSGAGHVRVFIDHLLPAVIPqllVLATLDIGHMMLHV---AGLSFLGLGvT 213

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491675627 251 ANTISWGIMLYNVQT---SSAMLIgawwevLAPCIALTLLVTGLALLNFAVDEIANPQLRSHKG 311
Cdd:PRK10417 214 APTAEWGVMINDARQyiwTQPLLM------FWPGLALFISVMAFNLLGDALRDHLDPHLVTEHA 271
PRK09881 PRK09881
D,D-dipeptide ABC transporter permease;
2-307 4.55e-31

D,D-dipeptide ABC transporter permease;


Pssm-ID: 182131 [Multi-domain]  Cd Length: 296  Bit Score: 118.77  E-value: 4.55e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491675627   2 KELFKLILGNAFARVGLAIISVFIFVAVAAPLITQHAPDkrtgnpheypgfvvkqaqnnpdgwvaknlADDRRSLLMSKK 81
Cdd:PRK09881  21 AKLVWMLKGSPLTVTGAVIIVLMLLMMIFSPWLATHDPN-----------------------------AIDLTARLLPPS 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491675627  82 ADHVLGTSRMGRDIWSQVAYGARVSLGVGFGAGIIVCFLATVIGISAGYFGGRVDDVLSAAMNIMLVIPQLPLLFVLAAF 161
Cdd:PRK09881  72 AAHWFGTDEVGRDLFSRVLVGSQQSILAGLVVVAIAGMIGSLLGCLSGVLGGRADAIIMRIMDIMLSIPSLVLTMALAAA 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491675627 162 IGEAgPLTIALIIAGTSWAWGARVVRAQTMALREKEFVKAAEVLGESSMRIIFVEILPNLIP--IVGASF-IGSvmlAIN 238
Cdd:PRK09881 152 LGPS-LFNAMLAIAIVRIPFYVRLARGQALVVRQYTYVQAAKTFGASRWHLISWHILRNSLPplIVQASLdIGS---AIL 227

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491675627 239 TEAVISFLGLGDAN-TISWGIMlynVQTSSAMLIGAWWEVLAPCIALTLLVTGLALLNFAVDEIANPQLR 307
Cdd:PRK09881 228 MAATLGFIGLGAQQpSAEWGAM---VANGRNYVLDQWWYCAFPGAAILLTAVGFNLFGDGIRDLLDPKAG 294
PRK10913 PRK10913
dipeptide ABC transporter permease DppC;
1-307 3.83e-29

dipeptide ABC transporter permease DppC;


Pssm-ID: 182833 [Multi-domain]  Cd Length: 300  Bit Score: 113.72  E-value: 3.83e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491675627   1 MKELFKLILGNAFARVGLAIISVFIFVAVAAPLITQHAPDKRtgnpheypgfvVKQAQNNPDGWVAknladdrrsllmSK 80
Cdd:PRK10913  19 LQEFWHYFKRNKGAVVGLVYVVIMLFIAIFANWIAPHNPAEQ-----------FRDALLAPPVWQE------------GG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491675627  81 KADHVLGTSRMGRDIWSQVAYGARVSLGVGFGAGIIVCFLATVIGISAGYFGGRVDDVLSAAMNIMLVIPQLPLLFVLAA 160
Cdd:PRK10913  76 SWAHILGTDDVGRDVLSRLMYGARLSLLVGCLVVVLSLVMGVILGLIAGYFGGLVDNIIMRVVDIMLALPSLLLALVLVA 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491675627 161 FIGEAgPLTIALIIAGTSWAWGARVVRAQTMALREKEFVKAAEVLGESSMRIIFVEILPN-LIP-IVGASFIGSVmlAIN 238
Cdd:PRK10913 156 IFGPS-IVNAALALTFVALPHYVRLTRAAVLVEVNRDYVTASRVAGAGAMRQMFINILPNcLAPlIVQASLGFSN--AIL 232

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491675627 239 TEAVISFLGLG-DANTISWGIMLYNVQTSSAmliGAWWEVLAPCIALTLLVTGLALLNFAVDEIANPQLR 307
Cdd:PRK10913 233 DMAALGFLGMGaQPPTPEWGTMLSDVLQFAQ---SAWWVVTFPGLAILLTVLAFNLMGDGLRDALDPKLK 299
YejE COG4239
ABC-type microcin C transport system, permease component YejE [Secondary metabolites ...
 82-296 4.17e-28

ABC-type microcin C transport system, permease component YejE [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 443381 [Multi-domain]  Cd Length: 342  Bit Score: 111.78  E-value: 4.17e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491675627  82 ADHVLGTSRMGRDIWSQVAYGARVSlgVGFGagIIVCFLATVIGISAG----YFGGRVDDVLSAAMNIMLVIPQLPLLFV 157
Cdd:COG4239  119 AENWLGTDDQGRDVLARLIYGFRIS--VLFG--LALTVISSVIGVAAGavqgYFGGRVDLLFQRFIEIWSSMPELYLLII 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491675627 158 LAAFIgEAGPLTIALIIAGTSWAWGARVVRAQTMALREKEFVKAAEVLGESSMRIIFVEILPN-LIPIVgaSFIGSVML- 235
Cdd:COG4239  195 LSSIF-QPSFWLLLGILLLFGWMGLVGVVRAEFLRARNLEYVRAARALGVSDRRIMFRHILPNaMVATL--TFLPFILSg 271

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491675627 236 AINTEAVISFLGLG-DANTISWGIMLY----NVQtssamligAWWEVLAPCIALTLLvtgLALLNF 296
Cdd:COG4239  272 AITTLTSLDFLGFGlPPGSPSLGELLAqgknNLQ--------APWLGLSAFVVLALM---LSLLVF 326
PRK15406 PRK15406
oligopeptide ABC transporter permease OppC; Provisional
 71-299 3.72e-27

oligopeptide ABC transporter permease OppC; Provisional


Pssm-ID: 185304 [Multi-domain]  Cd Length: 302  Bit Score: 108.38  E-value: 3.72e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491675627  71 DDRRSLLMSKKAD----HVLGTSRMGRDIWSQVAYGARVSLGVGFGAGIIVCFLATVIGISAGYFGGRVDDVLSAAMNIM 146
Cdd:PRK15406  65 DDTDWGMMSSAPDmesgHYFGTDSSGRDLLVRVAIGGRISLMVGVAAALVAVVVGTLYGSLSGYLGGKVDSVMMRLLEIL 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491675627 147 LVIPQLPLLFVLAAFIGEaGPLTIALIIAGTSWAWGARVVRAQTMALREKEFVKAAEVLGESSMRIIFVEILPNL--IPI 224
Cdd:PRK15406 145 NSFPFMFFVILLVTFFGQ-NILLIFVAIGMVSWLDMARIVRGQTLSLKRKEFIEAAQVGGVSTRGIVLRHIVPNVlgVVV 223

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491675627 225 VGASFIGSVMlaINTEAVISFLGLGDANTI-SWGIMLYNVQTSSAMligAWWEVLAPCialTLLVTGLALLNFAVD 299
Cdd:PRK15406 224 VYASLLVPSM--ILFESFLSFLGLGTQEPLsSWGALLSDGANSMEV---SPWLLLFPA---GFLVVTLFCFNFIGD 291
PRK15082 PRK15082
glutathione ABC transporter permease GsiD; Provisional
 82-306 1.31e-21

glutathione ABC transporter permease GsiD; Provisional


Pssm-ID: 185040 [Multi-domain]  Cd Length: 301  Bit Score: 93.25  E-value: 1.31e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491675627  82 ADHVLGTSRMGRDIWSQVAYGARVSLGVGFGAGIIVCFLATVIGISAGYFGGRVDDVLSAAMNIMLVIPQLPLLFVLAAF 161
Cdd:PRK15082  78 LQHWFGVDSLGRDIFSRILVGARISLAAGFFSVAIGAAIGTVLGLLAGYYEGWWDRIIMRICDVLFAFPGILLAIAVVAI 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491675627 162 IGeAGPLTIALIIAGTSWAWGARVVRAQTMALREKEFVKAAEVLGESSMRIIFVEILPNLIPIVGASFIGSVMLAINTEA 241
Cdd:PRK15082 158 LG-SGMANVIIAVAIFSIPAFARLVRGNTLVLKQQTYIESARSIGASDWTILLRHILPGTVSSIVVYFTMRIGTSIITAA 236

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491675627 242 VISFLGLG-DANTISWGIMLYNVQtssAMLIGAWWEVLAPCIALTLLVTGLALLNFAVDEIANPQL 306
Cdd:PRK15082 237 SLSFLGLGaQPPTPEWGAMLNEAR---ADMVIAPHVALFPSLAIFLTVLAFNLLGDGLRDALDPKI 299
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 103-273 4.86e-21

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 88.87  E-value: 4.86e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491675627 103 ARVSLGVGFGAGIIVCFLATVIGISAGYFGGRVDDVLSAAMNIMLVIPQLPLLFVLAAFIGEAGPLTI-------ALIIA 175
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGIlpglglpALILA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491675627 176 GTSWAWGARVVRAQTMALREKEFVKAAEVLGESSMRIIFVEILPNLIPIVGASFIGSVMLAINTEAVISFLGLGDANTIS 255
Cdd:cd06261   81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPG 160

                        170
                 ....*....|....*...
gi 491675627 256 WGIMLYNVQTSSAMLIGA 273
Cdd:cd06261  161 TGLLLIFAILFPGDLGVA 178
PRK15111 PRK15111
peptide ABC transporter permease SapC;
86-294 1.21e-16

peptide ABC transporter permease SapC;


Pssm-ID: 185066 [Multi-domain]  Cd Length: 296  Bit Score: 78.98  E-value: 1.21e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491675627  86 LGTSRMGRDIWSQVAYGARVSlgvgFGAGIIVCFLATVIGISAGYFGGRVDDVLSAAMN----IMLVIPQLPLLFVLAAF 161
Cdd:PRK15111  78 LGTDDLGRDVLSRLLSGAAPT----VGGAFVVTLAATLCGLVLGVFAGATHGLRSAVLNhildTLLSIPSLLLAIIVVAF 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491675627 162 IGEAgpLTIALIIAgtsW-AWGARVVRAQTMALR---EKEFVKAAEVLGESSMRIIFVEILPNLIPIVGASFIGSVMLAI 237
Cdd:PRK15111 154 AGPS--LSHAMFAV---WlALLPRMVRSIYSAVHdelEKEYVIAARLDGASTLNILWYAVLPNITAGLVTEITRALSMAI 228

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 491675627 238 NTEAVISFLGLG-DANTISWGIMLYNvqtSSAMLIGAWWEVLAPCIALTLLVTGLALL 294
Cdd:PRK15111 229 LDIAALGFLDLGaQLPSPEWGAMLGD---SLELIYVAPWTVMLPGAAIMLSVLLVNLL 283
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 121-273 1.41e-13

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 68.09  E-value: 1.41e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491675627  121 ATVIGISAG-YFGGRVDDVLSAAMNIMLVIP---QLPLLFVLAAFIGEAGPLTIALIIAGTSWAWGARVVRAQTMALREK 196
Cdd:pfam00528   1 GIPLGIIAAlRRGRRLDRLLRPLIDLLQALPsfvLAILLVVIAILSILGHGILPAIILALLGWAGYARLIRRAALRSLPS 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491675627  197 EFVKAAEVLGESSMRIIFVEILPNLIPIVGASFIGSVMLAINTEAVISFLGL--GDANTISWGIMLYNVQTSSAMLIGA 273
Cdd:pfam00528  81 DLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSwpGLGLLLIEAILGYDYPEIQGPVLAA 159
PRK15021 PRK15021
microcin C ABC transporter permease; Provisional
 82-304 2.38e-12

microcin C ABC transporter permease; Provisional


Pssm-ID: 184982 [Multi-domain]  Cd Length: 341  Bit Score: 66.93  E-value: 2.38e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491675627  82 ADHVLGTSRMGRDIWSQVAYGARVSLGVGFGAGIIVCFLATVIGISAGYFGGRVDDVLSAAMNIMLVIPQLPLLFVLAAF 161
Cdd:PRK15021 119 RQNWLGTDANGGDVLARILYGTRISVLFGLMLTLCSSVMGVLAGALQGYYGGKVDLWGQRFIEVWSGMPTLFLIILLSSV 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491675627 162 IGEAGPLTIALIIAgTSWAWGARVVRAQTMALREKEFVKAAEVLGESSMRIIFVEILPNLIpIVGASFIGSVML-AINTE 240
Cdd:PRK15021 199 VQPNFWWLLAITVL-FGWMSLVGVVRAEFLRTRNFDYIRAAQALGVSDRSIILRHMLPNAM-VATLTFLPFILCsSITTL 276

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491675627 241 AVISFLGLG-DANTISWGIMLYNVQTSsamlIGAWWEVLAPCIALTLLVTGLALLNFAVDEIANP 304
Cdd:PRK15021 277 TSLDFLGFGlPLGSPSLGELLLQGKNN----LQAPWLGITAFLSVAILLSLLIFIGEAVRDAFDP 337
DppB COG0601
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 86-249 5.12e-09

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


Pssm-ID: 440366 [Multi-domain]  Cd Length: 314  Bit Score: 56.61  E-value: 5.12e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491675627  86 LGTS-RMGRDIWSQVAYGARVSLGVGFGAGIIVCFLATVIGISAGYF-GGRVDDVLSAAMNIMLVIP------------- 150
Cdd:COG0601   77 LGTSfVYGRPVSDLIAERLPVTLELALLALLLALLIGIPLGILAALRrGSWLDRLITVLALLGISIPsfwlglllillfa 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491675627 151 -QLPLLFVLAAFIGEAGPLTI-------ALIIAGTSWAWGARVVRAQTMALREKEFVKAAEVLGESSMRIIFVEILPN-L 221
Cdd:COG0601  157 vKLGWLPVSGRVSPWEDFLDAlrhlilpALTLALGSLAGIARLTRSSMLEVLGQDYVRTARAKGLSERRVLLRHALRNaL 236

                        170       180       190
                 ....*....|....*....|....*....|.
gi 491675627 222 IPIV---GASFIGSVMLAINTEAVISFLGLG 249
Cdd:COG0601  237 IPVVtvlGLQLGGLLGGAVVVETVFSWPGLG 267
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
103-294 2.07e-04

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 42.84  E-value: 2.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491675627 103 ARVSLGVGFGAGIIVCFLATVIGISAGYFGGRVDDVLSAAMNIMLVIP----QLPLLFVLAAFIGEAGPLTIALIIAGTS 178
Cdd:COG1178  340 LLNSLLLALLAALLAVLLALLLAYLVRRRRGRLARLLDRLAMLPYAVPgivlGLGLLLLFNRPLPLLLYGTLAILVLAYV 419

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491675627 179 WAWGARVVRAQTMALRE--KEFVKAAEVLGESSMRIIFVEILPNLIPIVGASFIGSVMLAINTEAVISFLGLGDANTISw 256
Cdd:COG1178  420 VRFLPFALRSLEAALAQidPSLEEAARSLGASPLRTLRRVTLPLLRPGLLAAALLVFVTSMKELSATLLLRPPGFETLA- 498

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 491675627 257 gIMLYNVQTSSAMLIGAwwevlAPCIALTLLVTGLALL 294
Cdd:COG1178  499 -VLIYQLASSGRYGEAA-----ALALLLVLVSLLPVLL 530
PRK15110 PRK15110
peptide ABC transporter permease SapB;
184-260 4.57e-03

peptide ABC transporter permease SapB;


Pssm-ID: 185065 [Multi-domain]  Cd Length: 321  Bit Score: 38.52  E-value: 4.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491675627 184 RVVRAQTMALREKEFVKAAEVLGESSMRIIFVEI----LPNLIPIVGASFIGSVMLAINTEAVISFLGLG---------- 249
Cdd:PRK15110 200 RLMRISTIEVYDQNYVKAAATRGLSRFTILRRHVlhnaLPPVIPRLGLQFSTMLTLAMITEMVFSWPGLGrwlinairqq 279

                         90
                 ....*....|.
gi 491675627 250 DANTISWGIML 260
Cdd:PRK15110 280 DYAAISAGVMV 290
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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