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Conserved domains on  [gi|490412626|ref|WP_004285265|]
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uracil-DNA glycosylase [Neisseria weaveri]

Protein Classification

uracil-DNA glycosylase( domain architecture ID 10786350)

uracil-DNA glycosylase (UDG) excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine

CATH:  3.40.470.10
EC:  3.2.2.27
Gene Ontology:  GO:0004844|GO:0006281|GO:0006284
PubMed:  11716455|10946227|25550433

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Ung COG0692
Uracil-DNA glycosylase [Replication, recombination and repair];
1-217 6.18e-160

Uracil-DNA glycosylase [Replication, recombination and repair];


:

Pssm-ID: 440456  Cd Length: 221  Bit Score: 440.64  E-value: 6.18e-160
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490412626   1 MESWKEALGAEKELPYFRHILETVRAERMQGEVVYPPASDVFNAFKATEFGRVKVVILGQDPYHGPGQAHGLAFSVRPDI 80
Cdd:COG0692    6 EPSWKEALAEEFEKPYFQALGAFLKAEYAAGKTIYPPGEDIFRAFNLTPFDDVKVVILGQDPYHGPGQAHGLSFSVPPGV 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490412626  81 QIPPSLKNIYKEMADDIaGFRIPHHGCLQAWAEQGVLLLNTVLTVRAGQAHSHADLGWETFTDKAVRQLAEHREHLVFIL 160
Cdd:COG0692   86 PLPPSLRNIYKELEDDL-GIPIPNHGDLTSWAEQGVLLLNTVLTVRAGQAGSHAGKGWETFTDAVIRALNARKEPVVFLL 164

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 490412626 161 WGSHAQKKGAFIDRNRHLVLTSAHPSPLSAYRGFFGSRPFSKANAYLAAHGQTPIDW 217
Cdd:COG0692  165 WGAYAQKKAALIDASKHLVLESPHPSPLSAHRGFFGSKPFSKANAYLEEQGKTPIDW 221
 
Name Accession Description Interval E-value
Ung COG0692
Uracil-DNA glycosylase [Replication, recombination and repair];
1-217 6.18e-160

Uracil-DNA glycosylase [Replication, recombination and repair];


Pssm-ID: 440456  Cd Length: 221  Bit Score: 440.64  E-value: 6.18e-160
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490412626   1 MESWKEALGAEKELPYFRHILETVRAERMQGEVVYPPASDVFNAFKATEFGRVKVVILGQDPYHGPGQAHGLAFSVRPDI 80
Cdd:COG0692    6 EPSWKEALAEEFEKPYFQALGAFLKAEYAAGKTIYPPGEDIFRAFNLTPFDDVKVVILGQDPYHGPGQAHGLSFSVPPGV 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490412626  81 QIPPSLKNIYKEMADDIaGFRIPHHGCLQAWAEQGVLLLNTVLTVRAGQAHSHADLGWETFTDKAVRQLAEHREHLVFIL 160
Cdd:COG0692   86 PLPPSLRNIYKELEDDL-GIPIPNHGDLTSWAEQGVLLLNTVLTVRAGQAGSHAGKGWETFTDAVIRALNARKEPVVFLL 164

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 490412626 161 WGSHAQKKGAFIDRNRHLVLTSAHPSPLSAYRGFFGSRPFSKANAYLAAHGQTPIDW 217
Cdd:COG0692  165 WGAYAQKKAALIDASKHLVLESPHPSPLSAHRGFFGSKPFSKANAYLEEQGKTPIDW 221
PRK05254 PRK05254
uracil-DNA glycosylase; Provisional
 1-219 1.68e-158

uracil-DNA glycosylase; Provisional


Pssm-ID: 235376  Cd Length: 224  Bit Score: 437.28  E-value: 1.68e-158
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490412626   1 MESWKEALGAEKELPYFRHILETVRAERMQGEVVYPPASDVFNAFKATEFGRVKVVILGQDPYHGPGQAHGLAFSVRPDI 80
Cdd:PRK05254   7 EPSWKEVLKPEFKKPYFQELLEFLRAERAAGKTIYPPGEDIFRAFNLTPFDDVKVVILGQDPYHGPGQAHGLSFSVPPGV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490412626  81 QIPPSLKNIYKEMADDIaGFRIPHHGCLQAWAEQGVLLLNTVLTVRAGQAHSHADLGWETFTDKAVRQLAEHREHLVFIL 160
Cdd:PRK05254  87 PIPPSLRNIFKELEDDL-GFPIPNHGDLTSWAEQGVLLLNTVLTVEAGQANSHAGKGWETFTDAVIKALNERREPVVFIL 165

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 490412626 161 WGSHAQKKGAFIDRNRHLVLTSAHPSPLSAYRGFFGSRPFSKANAYLAAHGQTPIDWQL 219
Cdd:PRK05254 166 WGSHAQKKKALIDNSKHLILESPHPSPLSAHRGFFGSKHFSKANALLKQHGKTPIDWQL 224
UDG-F1-like cd10027
Uracil DNA glycosylase family 1 subfamily, includes Human uracil DNA glycosylase and similar ...
 16-217 3.92e-136

Uracil DNA glycosylase family 1 subfamily, includes Human uracil DNA glycosylase and similar proteins; Uracil DNA glycosylase family 1 is the most efficient of all uracil-DNA glycosylases (UDGs, also known as UNGs) and shows a specificity for uracil in DNA. UDG catalyzes the removal of uracil from DNA to initiate the DNA base excision repair pathway. Uracil in DNA can arise as a result of mis-incorporation of dUMP residues by DNA polymerase or deamination of cytosine. Uracil mispaired with guanine in DNA is one of the major pro-mutagenic events, causing G:C->A:T mutations. Thus, UDG is an essential enzyme for maintaining the integrity of genetic information. UDGs have been classified into various families on the basis of their substrate specificity, conserved motifs, and structural similarities. Although these families demonstrate different substrate specificities, often the function of one enzyme can be complemented by the other.


Pssm-ID: 381678  Cd Length: 200  Bit Score: 379.49  E-value: 3.92e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490412626  16 YFRHILETVRAERmQGEVVYPPASDVFNAFKATEFGRVKVVILGQDPYHGPGQAHGLAFSVRPDIQIPPSLKNIYKEMAD 95
Cdd:cd10027    1 YFKKLEAFLEEEY-KKKTIYPPKEDIFRAFELTPLDDVKVVILGQDPYHGPGQAHGLAFSVPPGVKIPPSLRNIFKELKS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490412626  96 DIAGFrIPHHGCLQAWAEQGVLLLNTVLTVRAGQAHSHADLGWETFTDKAVRQLAEHREHLVFILWGSHAQKKGAFIDRN 175
Cdd:cd10027   80 DLGIF-PPKHGDLSSWAKQGVLLLNTVLTVEAGKPGSHKNIGWETFTDAVIKALSEKNENVVFLLWGNHAQKKKKLIDKK 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 490412626 176 RHLVLTSAHPSPLSAYRGFFGSRPFSKANAYLAAHGQTPIDW 217
Cdd:cd10027  159 KHLVLESSHPSPLSAYRGFFGSKHFSKANEYLKKHGKKPIDW 200
ung TIGR00628
uracil-DNA glycosylase; All proteins in this family for which functions are known are ...
 2-212 3.65e-125

uracil-DNA glycosylase; All proteins in this family for which functions are known are uracil-DNA glycosylases that function in base excision repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273182  Cd Length: 211  Bit Score: 352.29  E-value: 3.65e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490412626    2 ESWKEALGAEKELPYFRHILETVRAERmQGEVVYPPASDVFNAFKATEFGRVKVVILGQDPYHGPGQAHGLAFSVRPDIQ 81
Cdd:TIGR00628   2 PSWRAFLQPEFKKPYFQELLAFYKRER-AQETVYPPKEDVFAWTRLCPPEDVKVVILGQDPYHGPGQAHGLAFSVKRGVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490412626   82 IPPSLKNIYKEMADDIAGFRIPHHGCLQAWAEQGVLLLNTVLTVRAGQAHSHADLGWETFTDKAVRQLAEHREHLVFILW 161
Cdd:TIGR00628  81 IPPSLKNIFKELEADYPDFPPPKHGCLEAWARQGVLLLNTVLTVRRGQPGSHSGLGWERFTDAVISRLSERLDGLVFMLW 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 490412626  162 GSHAQKKGAFIDRNRHLVLTSAHPSPLSAYRGFFGSRPFSKANAYLAAHGQ 212
Cdd:TIGR00628 161 GAHAQKKKSLIDAKKHLVLKSPHPSPLSARRGFFGCRHFSKANEYLEKHGK 211
UDG smart00986
Uracil DNA glycosylase superfamily;
50-207 5.39e-31

Uracil DNA glycosylase superfamily;


Pssm-ID: 214956  Cd Length: 156  Bit Score: 111.32  E-value: 5.39e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490412626    50 FGRVKVVILGQDPYHGPGQ-------AHGLAFSVRP----DIQIPPSLKNIYKEMADDIAgfriphHGCLQAWAEQGVLL 118
Cdd:smart00986   5 DPNAKVLIVGQAPGASEEDrggpfvgAAGLLLSVMLgvagLPRLPPYLTNIVKCRPPDAG------NRRPTSWELQGCLL 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490412626   119 lnTVLTVRAGQAHSHADLGWETFTDKAVRQLAEHreHLVFILWGSHAQKKGAfidrnRHLVLTSAHPSPLSAYRgfFGSR 198
Cdd:smart00986  79 --PWLTVELALARPHLILLLGKFAAQALLGLLRR--PLVFGLRGRVAQLKGK-----GHRVLPLPHPSPLNRNF--FPAK 147


                   ....*....
gi 490412626   199 PFSKANAYL 207
Cdd:smart00986 148 KFAAWNDLL 156
UDG pfam03167
Uracil DNA glycosylase superfamily;
53-206 1.98e-20

Uracil DNA glycosylase superfamily;


Pssm-ID: 397331  Cd Length: 154  Bit Score: 83.94  E-value: 1.98e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490412626   53 VKVVILGQDPYHGpGQAHGLAFSVRPDiQIPPSLKNIykemaddiAGFRiphhgcLQAWAEQGVLLLNTVLTVR--AGQA 130
Cdd:pfam03167   8 AKVLIVGEAPGAD-EDATGLPFVGRAG-NLLWKLLNA--------AGLT------RDLFSPQGVYITNVVKCRPgnRRKP 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490412626  131 HSHA-DLGWEtFTDKAVRQLAEHrehlVFILWGSHAQKK-----------GAFIDRNRHLVLTSAHPSPLSAYRgffgSR 198
Cdd:pfam03167  72 TSHEiDACWP-YLEAEIELLRPR----VIVLLGKTAAKAllglkkitklrGKLIDLKGIPVLPTPHPSPLLRNK----LN 142


                  ....*...
gi 490412626  199 PFSKANAY 206
Cdd:pfam03167 143 PFLKANAW 150
 
Name Accession Description Interval E-value
Ung COG0692
Uracil-DNA glycosylase [Replication, recombination and repair];
1-217 6.18e-160

Uracil-DNA glycosylase [Replication, recombination and repair];


Pssm-ID: 440456  Cd Length: 221  Bit Score: 440.64  E-value: 6.18e-160
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490412626   1 MESWKEALGAEKELPYFRHILETVRAERMQGEVVYPPASDVFNAFKATEFGRVKVVILGQDPYHGPGQAHGLAFSVRPDI 80
Cdd:COG0692    6 EPSWKEALAEEFEKPYFQALGAFLKAEYAAGKTIYPPGEDIFRAFNLTPFDDVKVVILGQDPYHGPGQAHGLSFSVPPGV 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490412626  81 QIPPSLKNIYKEMADDIaGFRIPHHGCLQAWAEQGVLLLNTVLTVRAGQAHSHADLGWETFTDKAVRQLAEHREHLVFIL 160
Cdd:COG0692   86 PLPPSLRNIYKELEDDL-GIPIPNHGDLTSWAEQGVLLLNTVLTVRAGQAGSHAGKGWETFTDAVIRALNARKEPVVFLL 164

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 490412626 161 WGSHAQKKGAFIDRNRHLVLTSAHPSPLSAYRGFFGSRPFSKANAYLAAHGQTPIDW 217
Cdd:COG0692  165 WGAYAQKKAALIDASKHLVLESPHPSPLSAHRGFFGSKPFSKANAYLEEQGKTPIDW 221
PRK05254 PRK05254
uracil-DNA glycosylase; Provisional
 1-219 1.68e-158

uracil-DNA glycosylase; Provisional


Pssm-ID: 235376  Cd Length: 224  Bit Score: 437.28  E-value: 1.68e-158
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490412626   1 MESWKEALGAEKELPYFRHILETVRAERMQGEVVYPPASDVFNAFKATEFGRVKVVILGQDPYHGPGQAHGLAFSVRPDI 80
Cdd:PRK05254   7 EPSWKEVLKPEFKKPYFQELLEFLRAERAAGKTIYPPGEDIFRAFNLTPFDDVKVVILGQDPYHGPGQAHGLSFSVPPGV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490412626  81 QIPPSLKNIYKEMADDIaGFRIPHHGCLQAWAEQGVLLLNTVLTVRAGQAHSHADLGWETFTDKAVRQLAEHREHLVFIL 160
Cdd:PRK05254  87 PIPPSLRNIFKELEDDL-GFPIPNHGDLTSWAEQGVLLLNTVLTVEAGQANSHAGKGWETFTDAVIKALNERREPVVFIL 165

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 490412626 161 WGSHAQKKGAFIDRNRHLVLTSAHPSPLSAYRGFFGSRPFSKANAYLAAHGQTPIDWQL 219
Cdd:PRK05254 166 WGSHAQKKKALIDNSKHLILESPHPSPLSAHRGFFGSKHFSKANALLKQHGKTPIDWQL 224
UDG-F1-like cd10027
Uracil DNA glycosylase family 1 subfamily, includes Human uracil DNA glycosylase and similar ...
 16-217 3.92e-136

Uracil DNA glycosylase family 1 subfamily, includes Human uracil DNA glycosylase and similar proteins; Uracil DNA glycosylase family 1 is the most efficient of all uracil-DNA glycosylases (UDGs, also known as UNGs) and shows a specificity for uracil in DNA. UDG catalyzes the removal of uracil from DNA to initiate the DNA base excision repair pathway. Uracil in DNA can arise as a result of mis-incorporation of dUMP residues by DNA polymerase or deamination of cytosine. Uracil mispaired with guanine in DNA is one of the major pro-mutagenic events, causing G:C->A:T mutations. Thus, UDG is an essential enzyme for maintaining the integrity of genetic information. UDGs have been classified into various families on the basis of their substrate specificity, conserved motifs, and structural similarities. Although these families demonstrate different substrate specificities, often the function of one enzyme can be complemented by the other.


Pssm-ID: 381678  Cd Length: 200  Bit Score: 379.49  E-value: 3.92e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490412626  16 YFRHILETVRAERmQGEVVYPPASDVFNAFKATEFGRVKVVILGQDPYHGPGQAHGLAFSVRPDIQIPPSLKNIYKEMAD 95
Cdd:cd10027    1 YFKKLEAFLEEEY-KKKTIYPPKEDIFRAFELTPLDDVKVVILGQDPYHGPGQAHGLAFSVPPGVKIPPSLRNIFKELKS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490412626  96 DIAGFrIPHHGCLQAWAEQGVLLLNTVLTVRAGQAHSHADLGWETFTDKAVRQLAEHREHLVFILWGSHAQKKGAFIDRN 175
Cdd:cd10027   80 DLGIF-PPKHGDLSSWAKQGVLLLNTVLTVEAGKPGSHKNIGWETFTDAVIKALSEKNENVVFLLWGNHAQKKKKLIDKK 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 490412626 176 RHLVLTSAHPSPLSAYRGFFGSRPFSKANAYLAAHGQTPIDW 217
Cdd:cd10027  159 KHLVLESSHPSPLSAYRGFFGSKHFSKANEYLKKHGKKPIDW 200
ung TIGR00628
uracil-DNA glycosylase; All proteins in this family for which functions are known are ...
 2-212 3.65e-125

uracil-DNA glycosylase; All proteins in this family for which functions are known are uracil-DNA glycosylases that function in base excision repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273182  Cd Length: 211  Bit Score: 352.29  E-value: 3.65e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490412626    2 ESWKEALGAEKELPYFRHILETVRAERmQGEVVYPPASDVFNAFKATEFGRVKVVILGQDPYHGPGQAHGLAFSVRPDIQ 81
Cdd:TIGR00628   2 PSWRAFLQPEFKKPYFQELLAFYKRER-AQETVYPPKEDVFAWTRLCPPEDVKVVILGQDPYHGPGQAHGLAFSVKRGVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490412626   82 IPPSLKNIYKEMADDIAGFRIPHHGCLQAWAEQGVLLLNTVLTVRAGQAHSHADLGWETFTDKAVRQLAEHREHLVFILW 161
Cdd:TIGR00628  81 IPPSLKNIFKELEADYPDFPPPKHGCLEAWARQGVLLLNTVLTVRRGQPGSHSGLGWERFTDAVISRLSERLDGLVFMLW 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 490412626  162 GSHAQKKGAFIDRNRHLVLTSAHPSPLSAYRGFFGSRPFSKANAYLAAHGQ 212
Cdd:TIGR00628 161 GAHAQKKKSLIDAKKHLVLKSPHPSPLSARRGFFGCRHFSKANEYLEKHGK 211
PHA03347 PHA03347
uracil DNA glycosylase; Provisional
 15-219 2.23e-85

uracil DNA glycosylase; Provisional


Pssm-ID: 177588  Cd Length: 252  Bit Score: 253.05  E-value: 2.23e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490412626  15 PYFRH----ILETVRAERMQgEVVYPPASDVFNAFKATEFGRVKVVILGQDPYHGpGQAHGLAFSVRPDIQIPPSLKNIY 90
Cdd:PHA03347  38 PFLKQkllaLLNCVRELRKQ-TVIYPPEDRIMAWSYLCDPEDIKVVILGQDPYHG-GQANGLAFSVAYGFPVPPSLRNIF 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490412626  91 KEMADDIAGFRIPHHGCLQAWAEQGVLLLNTVLTVRAGQAHSHADLGWETFTDKAVRQLAEHREHLVFILWGSHAQKKGA 170
Cdd:PHA03347 116 AELHRSVPDFSPPDHGCLDAWARQGVLLLNTILTVEKGKPGSHSDLGWAWFTDYIISSLSEKLKACVFMLWGSKAIDKAS 195

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 490412626 171 FIDRNRHLVLTSAHPSPLSA---YRG----FFGSRPFSKANAYLAAHGQTPIDWQL 219
Cdd:PHA03347 196 LINSQKHLVLKAQHPSPLAAnstRSStwpkFLGCNHFVLANKYLTQHGKGPIDWNL 251
PHA03200 PHA03200
uracil DNA glycosylase; Provisional
 11-219 3.03e-85

uracil DNA glycosylase; Provisional


Pssm-ID: 165467  Cd Length: 255  Bit Score: 253.11  E-value: 3.03e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490412626  11 EKELPYFRHILETVRAERmQGEVVYPPASDVFNAFKATEFGRVKVVILGQDPYHGpGQAHGLAFSVRPDIQIPPSLKNIY 90
Cdd:PHA03200  44 DHDISQLRRIVDAVDRDR-QRLTVYPPPEDVHRWSRLCSPEDVKVVIVGQDPYHD-GSACGLAFGTVRGRSAPPSLKNVF 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490412626  91 KEMADDIAGFRIPHHGCLQAWAEQGVLLLNTVLTVRAGQAHSHADLGWETFTDKAVRQLAEHREHLVFILWGSHAQKKGA 170
Cdd:PHA03200 122 RELERTVPNFSRPDSGCLDSWCRQGVLLLNTVFTVVHGQPGSHEALGWQTLSDRVISRLSEKREHLVFMLWGAQAQKLEY 201

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 490412626 171 FIDRNRHLVLTSAHPSP--LSAYRGFFGSRPFSKANAYLAAHGQTPIDWQL 219
Cdd:PHA03200 202 LIDSRKHLILKSAHPSPrvKGARTPFIGNNHFVLANEYLSTHGKRPIDWNI 252
PHA03202 PHA03202
uracil DNA glycosylase; Provisional
 3-219 3.72e-76

uracil DNA glycosylase; Provisional


Pssm-ID: 165469  Cd Length: 313  Bit Score: 231.89  E-value: 3.72e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490412626   3 SWKEALGAEKELPYFRHILETVRAeRMQGEVVYPPASDVFNAFKATEFGRVKVVILGQDPYHGPGQAHGLAFSVRPDIQI 82
Cdd:PHA03202  99 SWRPILEREMQQPYVRLLLNEYKL-RCAREEVFPPKEDIFAWTRFSPPEKVRVVIVGQDPYHAPGQAHGLAFSVRKGVPV 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490412626  83 PPSLKNIYKEMADDIAGFRIPHHGCLQAWAEQGVLLLNTVLTVRAGQAHSHADLGWETFTDKAVRQLAEHREHLVFILWG 162
Cdd:PHA03202 178 PPSLRNIYSAVQKSYPSFRPPMHGFLEKWAEQGVLLINTTLTVARGKPGSHATLGWHRLVRAVIDRLCTTSQGLVFMLWG 257

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 490412626 163 SHAQKKGAfIDRNRHLVLTSAHPSPLSayRGFFGSRP-FSKANAYLAAHGQTPIDWQL 219
Cdd:PHA03202 258 AHAQKSCS-PNRQHHLVLTYGHPSPLS--RVNFRDCPhFLEANAYLTKTGRKPVDWQI 312
PHA03199 PHA03199
uracil DNA glycosylase; Provisional
 4-219 3.43e-68

uracil DNA glycosylase; Provisional


Pssm-ID: 165466  Cd Length: 304  Bit Score: 211.40  E-value: 3.43e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490412626   4 WKEALGAEKELPYFRHILETVRAERMQGEVVYPPASDVFNAFKATEFGRVKVVILGQDPYHGPGQAHGLAFSVRPDIQIP 83
Cdd:PHA03199  91 WHDLLRDEFEEPYAKGIFEEYNQLLNNGEEIFPIKGDIFAWTRFCGPEKIRVVIIGQDPYHGAGHAHGLAFSVKRGIPIP 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490412626  84 PSLKNIYKEMADDIAGFRIPHHGCLQAWAEQGVLLLNTVLTVRAGQAHSHADLGWETFTDKAVRQLAEHREHLVFILWGS 163
Cdd:PHA03199 171 PSLKNIFAALMESYPHLPLPTHGCLDNWARQGVLLLNTTLTVKRGTPGSHFYLGWDMLIKRMLKRLCENRTGLVFMLWGA 250

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 490412626 164 HAQKKgafIDRN--RHLVLTSAHPSPLSAYRgFFGSRPFSKANAYLAAHGQTPIDWQL 219
Cdd:PHA03199 251 HAQKT---IQPNprCHLVLTHAHPSPLSRSE-FRNCKHFLQANEYFLKKGEPEIDWSI 304
PHA03201 PHA03201
uracil DNA glycosylase; Provisional
 2-217 3.75e-66

uracil DNA glycosylase; Provisional


Pssm-ID: 165468  Cd Length: 318  Bit Score: 206.67  E-value: 3.75e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490412626   2 ESWKEALGAEKELPYFRHIL-ETVRaeRMQGEVVYPPASDVFNAFKATEFGRVKVVILGQDPYHGPGQAHGLAFSVRPDI 80
Cdd:PHA03201 104 DAWRPLLEPELANPLTARLMaEYER--RCRTEEVLPPREDVFSWTRYCTPDEVRVVIIGQDPYHQPGQAHGLAFSVRPGT 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490412626  81 QIPPSLKNIYKEMADDIAGFRIPHHGCLQAWAEQGVLLLNTVLTVRAGQAHSHADLGWETFTDKAVRQLAEHREHLVFIL 160
Cdd:PHA03201 182 PAPPSLRNILAAVRNCCPDARMSGHGCLEKWARGGVLLLNTTLTVRRGEPASHAKIGWDRFVGSVVRRLAASRPGLVFML 261

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 490412626 161 WGSHAQkKGAFIDRNRHLVLTSAHPSPLSayRGFFGS-RPFSKANAYLAAHGQTPIDW 217
Cdd:PHA03201 262 WGAHAQ-NAIRPDPRVHRVLTYSHPSPLS--KVPFGScRHFCLANQYLRERSLAPIDW 316
PHA03204 PHA03204
uracil DNA glycosylase; Provisional
 2-219 5.33e-63

uracil DNA glycosylase; Provisional


Pssm-ID: 165471  Cd Length: 322  Bit Score: 198.65  E-value: 5.33e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490412626   2 ESWKEALGAEKELPYFRHIL-ETVRaeRMQGEVVYPPASDVFNAFKATEFGRVKVVILGQDPYHGPGQAHGLAFSVRPDI 80
Cdd:PHA03204 104 CRWKEILLPELCCPTGSKILaEYER--RARYEEVYPPKSDIFAWTRYCAPDHVKVVIVGQDPYANPGQAHGLAFSVKPGS 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490412626  81 QIPPSLKNIYKEMADDIAGFRIPHHGCLQAWAEQGVLLLNTVLTVRAGQAHSHADLGWETFTDKAVRQLAEHREHLVFIL 160
Cdd:PHA03204 182 PIPPSLKNILAAVKACYPSIELGSHGCLEDWAKRGVLLLNSVLTVKRGDPGSHHSVGWQILVRNVLRRLSQSTRGIVFML 261

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 490412626 161 WGSHAQKKGAFIDRN-RHLVLTSAHPSPLSAyRGFFGSRPFSKANAYLAAHGQTPIDWQL 219
Cdd:PHA03204 262 WGAQAQTMYFQTDNDdRHLVLKYSHPSPLSR-KPFAHCTHFKDANEFLCKMGKGAIDWSL 320
UDG-F1-like cd19371
Uracil DNA glycosylase family 1, includes Human uracil DNA glycosylase, Vaccinia virus protein ...
 55-189 7.13e-55

Uracil DNA glycosylase family 1, includes Human uracil DNA glycosylase, Vaccinia virus protein D4, Nitratifractor salsuginis UNG and similar proteins; Uracil DNA glycosylase family 1 is the most efficient of all uracil-DNA glycosylases (UDGs, also known as UNGs) and shows a specificity for uracil in DNA. UDG catalyzes the removal of uracil from DNA to initiate the DNA base excision repair pathway. Uracil in DNA can arise as a result of misincorporation of dUMP residues by DNA polymerase or deamination of cytosine. Uracil mispaired with guanine in DNA is one of the major pro-mutagenic events, causing G:C->A:T mutations. Thus, UDG is an essential enzyme for maintaining the integrity of genetic information. UDGs have been classified into various families on the basis of their substrate specificity, conserved motifs, and structural similarities. Although these families demonstrate different substrate specificities, often the function of one enzyme can be complemented by the other. More distant members of UDG family 1 include Nitratifractor salsuginis UNG (NsaUNG) and Vaccinia virus (VAVC) protein D4 uracil-DNA glycosylase, a subunit of the VACV DNA polymerase holoenzyme. NsaUNG only exhibits robust enzymatic activity on uracil-containing DNAs, in particular double-stranded uracil-containing substrates; it does not act on hypoxanthine- and xanthine-containing substrates. NsUNG is not inhibited by Ugi protein that specifically inhibits conventional family 1 UDGs. D4, in addition to excising uracil residues from DNA, is part of a heterodimeric processivity factor which potentiates the DNA polymerase activity.


Pssm-ID: 381686  Cd Length: 135  Bit Score: 171.75  E-value: 7.13e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490412626  55 VVILGQDPYHGPGQAHGLAFSVRPDIQIPPSLKNIYKEMADDIAGFRIPHHGCLQAWAEQGVLLLNTVLTVRAGQAHSHA 134
Cdd:cd19371    1 VVIIGQDPYPSPGHAGGLAFSVTSEVPPPKSLRNIYKELERDYSSFLPPGNGTLEFWARQGVLLLNAALTCESGKPKSHY 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 490412626 135 DLgWETFTDKAVRQLAEHREHLVFILWGSHAQKKGAFIDRNRHLVLTSAHPSPLS 189
Cdd:cd19371   81 LL-WEPFIKAFIRYISAHNKGLVFLLFGSDAQKLRKKINGRNVHVFKADHPSPAD 134
UDG smart00986
Uracil DNA glycosylase superfamily;
50-207 5.39e-31

Uracil DNA glycosylase superfamily;


Pssm-ID: 214956  Cd Length: 156  Bit Score: 111.32  E-value: 5.39e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490412626    50 FGRVKVVILGQDPYHGPGQ-------AHGLAFSVRP----DIQIPPSLKNIYKEMADDIAgfriphHGCLQAWAEQGVLL 118
Cdd:smart00986   5 DPNAKVLIVGQAPGASEEDrggpfvgAAGLLLSVMLgvagLPRLPPYLTNIVKCRPPDAG------NRRPTSWELQGCLL 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490412626   119 lnTVLTVRAGQAHSHADLGWETFTDKAVRQLAEHreHLVFILWGSHAQKKGAfidrnRHLVLTSAHPSPLSAYRgfFGSR 198
Cdd:smart00986  79 --PWLTVELALARPHLILLLGKFAAQALLGLLRR--PLVFGLRGRVAQLKGK-----GHRVLPLPHPSPLNRNF--FPAK 147


                   ....*....
gi 490412626   199 PFSKANAYL 207
Cdd:smart00986 148 KFAAWNDLL 156
UDG pfam03167
Uracil DNA glycosylase superfamily;
53-206 1.98e-20

Uracil DNA glycosylase superfamily;


Pssm-ID: 397331  Cd Length: 154  Bit Score: 83.94  E-value: 1.98e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490412626   53 VKVVILGQDPYHGpGQAHGLAFSVRPDiQIPPSLKNIykemaddiAGFRiphhgcLQAWAEQGVLLLNTVLTVR--AGQA 130
Cdd:pfam03167   8 AKVLIVGEAPGAD-EDATGLPFVGRAG-NLLWKLLNA--------AGLT------RDLFSPQGVYITNVVKCRPgnRRKP 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490412626  131 HSHA-DLGWEtFTDKAVRQLAEHrehlVFILWGSHAQKK-----------GAFIDRNRHLVLTSAHPSPLSAYRgffgSR 198
Cdd:pfam03167  72 TSHEiDACWP-YLEAEIELLRPR----VIVLLGKTAAKAllglkkitklrGKLIDLKGIPVLPTPHPSPLLRNK----LN 142


                  ....*...
gi 490412626  199 PFSKANAY 206
Cdd:pfam03167 143 PFLKANAW 150
UDG-like cd09593
uracil-DNA glycosylases (UDG) and related enzymes; Uracil-DNA glycosylases (UDGs) initiate ...
 55-190 9.69e-19

uracil-DNA glycosylases (UDG) and related enzymes; Uracil-DNA glycosylases (UDGs) initiate repair of uracils in DNA. Uracil may arise from misincorporation of dUMP residues by DNA polymerase or via deamination of cytosine. Uracil in DNA mispaired with guanine is one of the major pro-mutagenic events, causing G:C->A:T mutations; thus, UDG is an essential enzyme for maintaining the integrity of genetic information. UDGs have been classified into various families on the basis of their substrate specificity, conserved motifs, and structural similarities. Although these families demonstrate different substrate specificities, often the function of one enzyme can be complemented by the other. UDG family 1 is the most efficient uracil-DNA glycosylase (UDG, also known as UNG) and shows a specificity for uracil in DNA. UDG family 2 includes thymine DNA glycosylase which removes uracil and thymine from G:U and G:T mismatches, and mismatch-specific uracil DNA glycosylase (MUG) which in Escherichia coli is highly specific to G:U mismatches, but also repairs G:T mismatches at high enzyme concentration. UDG family 3 includes Human SMUG1 which can remove uracil and its oxidized pyrimidine derivatives from, single-stranded DNA and double-stranded DNA with a preference for single-stranded DNA. Pedobacter heparinus SMUG2, which is UDG family 3 SMUG1-like, displays catalytic activities towards DNA containing uracil or hypoxanthine/xanthine. UDG family 4 includes Thermotoga maritima TTUDGA, a robust UDG which like family 1, acts on double-stranded and single-stranded uracil-containing DNA. UDG family 5 (UDGb) includes Thermus thermophilus HB8 TTUDGB which acts on double-stranded uracil-containing DNA; it is a hypoxanthine DNA glycosylase acting on double-stranded hypoxanthine-containing DNA except for the C/I base pair, as well as a xanthine DNA glycosylase which acts on both double-stranded and single-stranded xanthine-containing DNA. UDG family 6 hypoxanthine-DNA glycosylase lacks any detectable UDG activity; it excises hypoxanthine. Other UDG families include one represented by Bradyrhizobium diazoefficiens Blr0248 which prefers single-stranded DNA and removes uracil, 5-hydroxymethyl-uracil or xanthine from it.


Pssm-ID: 381677  Cd Length: 125  Bit Score: 78.58  E-value: 9.69e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490412626  55 VVILGQDPYHGPGQAHGlafsvrpdIQIPPSLKNIYKEMADDIAGFRiphhgclqaWAEQGVLLLNTVLTVRAGQAHSHA 134
Cdd:cd09593    1 VLIVGQNPGPHGARAGG--------VPPGPSGNRLWRLLAAAGGTPR---------LFRYGVGLTNTVPRGPPGAAAGSE 63

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490412626 135 DlGWETFTDKAVRQLAEHREHLVFILWGSHAQKKG-------AFIDRNRHLVLTSAHPSPLSA 190
Cdd:cd09593   64 K-KELRFCGRWLRKLLELLNPRVVVLLGKKAQEAYlavltssKGAPGKGTEVLVLPHPSPRNR 125
UDG_F1_VAVC_D4-like cd19372
Uracil DNA glycosylase family 1 subfamily, includes Vaccinia virus protein D4 and similar ...
 54-217 5.57e-05

Uracil DNA glycosylase family 1 subfamily, includes Vaccinia virus protein D4 and similar proteins; Vaccinia virus (VAVC) protein D4 uracil-DNA glycosylase, is a subunit of the VACV DNA polymerase holoenzyme, and a more distant member of uracil DNA glycosylase (UDG) family 1. D4, in addition to excising uracil residues from DNA, is part of a heterodimeric processivity factor which potentiates the DNA polymerase activity. UDG catalyzes the removal of uracil from DNA to initiate the DNA base excision repair pathway. Uracil in DNA can arise as a result of mis-incorporation of dUMP residues by DNA polymerase or deamination of cytosine. Uracil mispaired with guanine in DNA is one of the major pro-mutagenic events, causing G:C->A:T mutations. Thus, UDG is an essential enzyme for maintaining the integrity of genetic information. UDGs have been classified into various families on the basis of their substrate specificity, conserved motifs, and structural similarities. Although these families demonstrate different substrate specificities, often the function of one enzyme can be complemented by the other.


Pssm-ID: 381687  Cd Length: 200  Bit Score: 42.42  E-value: 5.57e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490412626  54 KVVILGQDPYhgPGQAHGLAFsvrpdiQIPPSLKNIYKEMADDIA-GFRIPHHGCLQAWAEQGVLLLNTVLTVRAGQAHS 132
Cdd:cd19372   43 RVCICGIDPY--PTDATGVPF------ESPDFSKKTIRAIAEAISrRTGVSLYKGYNFALVEGVLAWNYYLSCREGETKS 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490412626 133 HAdLGWETFTDKAVRQLAEHREHLVFiLWGSHAQKKGAFIDRNRHLVLtSAHPsplsAYRG--FFGSRPFSKANAYLAAH 210
Cdd:cd19372  115 HA-IHWERISKLLLQHIAKYVSVLYC-LGKTDFSNVRARLEVPVTVVV-GYHP----AARDgqFDKERAFEIVNVLLELN 187


                 ....*..
gi 490412626 211 GQTPIDW 217
Cdd:cd19372  188 GKPPVNW 194
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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