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Conserved domains on  [gi|490329716|ref|WP_004219138|]
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MULTISPECIES: response regulator transcription factor [Bifidobacterium]

Protein Classification

DNA-binding response regulator( domain architecture ID 10361306)

two-component system response regulator binds DNA upon phosphorylation and functions as transcriptional regulator

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
trans_reg_C cd00383
DNA-binding effector domain of two-component system response regulators; Bacteria and some ...
 136-223 2.24e-35

DNA-binding effector domain of two-component system response regulators; Bacteria and some eukaryotes use two-component signal transduction systems to detect and respond to changes in the environment. The systems consists of a sensor histidine kinase and a response regulator. The former autophosphorylates a histidine residue on detecting an external stimulus. The phosphate is then transferred to an invariant aspartate residue in a highly conserved receiver domain of the response regulator. Phosphorylation activates a variable effector domain of the response regulator, which triggers the cellular response. This C-terminal effector domain belongs to the winged helix-turn-helix family of transcriptional regulators and contains DNA and RNA polymerase binding sites. Several dimers or monomers bind head to tail to small tandem repeats upstream of the genes. The RNA polymerase binding sites interact with the alpha or sigma subunit of RNA polymerase.


:

Pssm-ID: 294013 [Multi-domain]  Cd Length: 89  Bit Score: 121.43  E-value: 2.24e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716 136 LVVDTNGYTANLRGVPIDLAYKEFELLKYLVQHPGRVFTRAQLLQEVWGYDYYGGTRTVDVHVRRLRAKLGGEYEH-LIG 214
Cdd:cd00383    1 LRLDPARREVTVDGEEVELTPKEFELLELLARNPGRVVSREELLEAVWGYDYEVDDRTVDVHISRLRKKLEDDPEPrLIK 80


                 ....*....
gi 490329716 215 TVRNVGYRF 223
Cdd:cd00383   81 TVRGVGYRL 89
REC super family cl19078
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 27-224 1.57e-33

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


The actual alignment was detected with superfamily member TIGR02154:

Pssm-ID: 473134 [Multi-domain]  Cd Length: 226  Bit Score: 120.90  E-value: 1.57e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716   27 DASSLVRMPENTILLLDARDDLASAKTLCRLLHASGLSTPI-VLILTEGGFTV--VNG-EWGVSDVIVNTASPAEVEGRL 102
Cdd:TIGR02154  37 EALTLINERGPDLILLDWMLPGTSGIELCRRLRRRPETRAIpIIMLTARGEEEdrVRGlETGADDYITKPFSPRELLARI 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716  103 RLVTERvatynvmpnalanSGPEDEDGLIRSGDLVVDTNGYTANLRGVPIDLAYKEFELLKYLVQHPGRVFTRAQLLQEV 182
Cdd:TIGR02154 117 KAVLRR-------------IRPQLSDEVIEVGDLSLDPVAHRVFRGGQPLSLGPTEFRLLHFFMTHPERVYSREQLLDRV 183

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 490329716  183 WGYDYYGGTRTVDVHVRRLRAKLGGE-YEHLIGTVRNVGYRFD 224
Cdd:TIGR02154 184 WGRDVYVEERTVDVHIRRLRKALNPFgLEDPVQTVRGAGYRFS 226
 
Name Accession Description Interval E-value
trans_reg_C cd00383
DNA-binding effector domain of two-component system response regulators; Bacteria and some ...
 136-223 2.24e-35

DNA-binding effector domain of two-component system response regulators; Bacteria and some eukaryotes use two-component signal transduction systems to detect and respond to changes in the environment. The systems consists of a sensor histidine kinase and a response regulator. The former autophosphorylates a histidine residue on detecting an external stimulus. The phosphate is then transferred to an invariant aspartate residue in a highly conserved receiver domain of the response regulator. Phosphorylation activates a variable effector domain of the response regulator, which triggers the cellular response. This C-terminal effector domain belongs to the winged helix-turn-helix family of transcriptional regulators and contains DNA and RNA polymerase binding sites. Several dimers or monomers bind head to tail to small tandem repeats upstream of the genes. The RNA polymerase binding sites interact with the alpha or sigma subunit of RNA polymerase.


Pssm-ID: 294013 [Multi-domain]  Cd Length: 89  Bit Score: 121.43  E-value: 2.24e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716 136 LVVDTNGYTANLRGVPIDLAYKEFELLKYLVQHPGRVFTRAQLLQEVWGYDYYGGTRTVDVHVRRLRAKLGGEYEH-LIG 214
Cdd:cd00383    1 LRLDPARREVTVDGEEVELTPKEFELLELLARNPGRVVSREELLEAVWGYDYEVDDRTVDVHISRLRKKLEDDPEPrLIK 80


                 ....*....
gi 490329716 215 TVRNVGYRF 223
Cdd:cd00383   81 TVRGVGYRL 89
PhoB TIGR02154
phosphate regulon transcriptional regulatory protein PhoB; PhoB is a DNA-binding response ...
 27-224 1.57e-33

phosphate regulon transcriptional regulatory protein PhoB; PhoB is a DNA-binding response regulator protein acting with PhoR in a 2-component system responding to phosphate ion. PhoB acts as a positive regulator of gene expression for phosphate-related genes such as phoA, phoS, phoE and ugpAB as well as itself. It is often found proximal to genes for the high-affinity phosphate ABC transporter (pstSCAB; GenProp0190) and presumably regulates these as well. [Regulatory functions, DNA interactions, Signal transduction, Two-component systems]


Pssm-ID: 131209 [Multi-domain]  Cd Length: 226  Bit Score: 120.90  E-value: 1.57e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716   27 DASSLVRMPENTILLLDARDDLASAKTLCRLLHASGLSTPI-VLILTEGGFTV--VNG-EWGVSDVIVNTASPAEVEGRL 102
Cdd:TIGR02154  37 EALTLINERGPDLILLDWMLPGTSGIELCRRLRRRPETRAIpIIMLTARGEEEdrVRGlETGADDYITKPFSPRELLARI 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716  103 RLVTERvatynvmpnalanSGPEDEDGLIRSGDLVVDTNGYTANLRGVPIDLAYKEFELLKYLVQHPGRVFTRAQLLQEV 182
Cdd:TIGR02154 117 KAVLRR-------------IRPQLSDEVIEVGDLSLDPVAHRVFRGGQPLSLGPTEFRLLHFFMTHPERVYSREQLLDRV 183

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 490329716  183 WGYDYYGGTRTVDVHVRRLRAKLGGE-YEHLIGTVRNVGYRFD 224
Cdd:TIGR02154 184 WGRDVYVEERTVDVHIRRLRKALNPFgLEDPVQTVRGAGYRFS 226
Trans_reg_C pfam00486
Transcriptional regulatory protein, C terminal;
149-223 4.62e-33

Transcriptional regulatory protein, C terminal;


Pssm-ID: 425712 [Multi-domain]  Cd Length: 77  Bit Score: 114.92  E-value: 4.62e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490329716  149 GVPIDLAYKEFELLKYLVQHPGRVFTRAQLLQEVWGYDYYGGTRTVDVHVRRLRAKLG--GEYEHLIGTVRNVGYRF 223
Cdd:pfam00486   1 GEEVELTPKEFKLLELLAENPGRVVSREQLLEEVWGEDYDVDDNTVDVHISRLRKKLEddPRDPRLIKTVRGVGYRL 77
Trans_reg_C smart00862
Transcriptional regulatory protein, C terminal; This domain is almost always found associated ...
 149-223 4.57e-32

Transcriptional regulatory protein, C terminal; This domain is almost always found associated with the response regulator receiver domain. It may play a role in DNA binding.


Pssm-ID: 214866 [Multi-domain]  Cd Length: 76  Bit Score: 112.26  E-value: 4.57e-32
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490329716   149 GVPIDLAYKEFELLKYLVQHPGRVFTRAQLLQEVWGYDYYGGTRTVDVHVRRLRAKLG-GEYEHLIGTVRNVGYRF 223
Cdd:smart00862   1 GEPIKLTPKEFRLLELLLRNPGRVVSREELLEAVWGDDEDVDDNTLDVHISRLRKKLEdDGDPRLIETVRGVGYRL 76
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 53-209 5.24e-30

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 111.20  E-value: 5.24e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716  53 TLCRLLHASGLSTPIvLILTEGG--FTVVNG-EWGVSDVIVNTASPAEVEGRLRLVTERVATynvmpnalansgpededG 129
Cdd:COG0745   62 EVCRRLRARPSDIPI-IMLTARDdeEDRVRGlEAGADDYLTKPFDPEELLARIRALLRRRAA-----------------E 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716 130 LIRSGDLVvDTNGYTANLRGVPIDLAYKEFELLKYLVQHPGRVFTRAQLLQEVWGYDyYGGTRTVDVHVRRLRAKLGGEY 209
Cdd:COG0745  124 VLRVGDLL-DLAAREVTRDGEPVELTPKEFRLLELLMRNPGRVVSREQLLEEVWGYD-YGDDRTVDVHISRLRKKLEDDL 201
resp_reg_YycF NF040534
response regulator YycF;
125-227 5.87e-30

response regulator YycF;


Pssm-ID: 439744 [Multi-domain]  Cd Length: 231  Bit Score: 111.74  E-value: 5.87e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716 125 EDEDGLIRSGDLVVDTNGYTANLRGVPIDLAYKEFELLKYLVQHPGRVFTRAQLLQEVWGYDYYGGTRTVDVHVRRLRAK 204
Cdd:NF040534 127 EEENNEIVIGSLTIHPDAYTVKKRGETIELTHREFELLHYLAKHIGQVMTREHLLQTVWGYDYFGDVRTVDVTVRRLREK 206

                         90       100
                 ....*....|....*....|....*
gi 490329716 205 LGGEYEH--LIGTVRNVGYRFDPPE 227
Cdd:NF040534 207 IEDNPSHpeWIVTRRGVGYYLRNPE 231
orf27 CHL00148
Ycf27; Reviewed
 82-223 8.44e-29

Ycf27; Reviewed


Pssm-ID: 214376 [Multi-domain]  Cd Length: 240  Bit Score: 109.04  E-value: 8.44e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716  82 EWGVSDVIVNTASPAEVEGRLRLVTERVatynvmpNALANSGPEDEDGLIRSGDLVVDTNGYTANLRGVPIDLAYKEFEL 161
Cdd:CHL00148  97 ELGADDYVVKPFSPKELEARIRSVLRRT-------NKKSFSSKIPNSSIIRIGFLKIDLNKKQVYKNNERIRLTGMEFSL 169

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490329716 162 LKYLVQHPGRVFTRAQLLQEVWGYDY--YGGTRTVDVHVRRLRAKLGGEYEH--LIGTVRNVGYRF 223
Cdd:CHL00148 170 LELLISKSGEIFSRATILKEVWGYTPerHIDTRVVDVHISRLRAKLEDDPSNpdLILTARGTGYLF 235
MtrAB_MtrA NF040689
MtrAB system response regulator MtrA;
55-222 6.85e-28

MtrAB system response regulator MtrA;


Pssm-ID: 468653 [Multi-domain]  Cd Length: 219  Bit Score: 106.11  E-value: 6.85e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716  55 CRLLHASGlSTPIVLiLTEGGFT--VVNG-EWGVSDVIVNTASPAEVEGRLRLVTERVAtynvmpnalansgpEDEDGLI 131
Cdd:NF040689  61 CRQIRAES-GVPIIM-LTAKSDTvdVVRGlEAGADDYVVKPFKPKELVARIRARLRRSE--------------DEESEVL 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716 132 RSGDLVVDTNGYTANLRGVPIDLAYKEFELLKYLVQHPGRVFTRAQLLQEVWGYDYYGGTRTVDVHVRRLRAKLGGEYEH 211
Cdd:NF040689 125 RIGDLTIDVAGHEVTRGGEEIPLTPLEFDLLVALARKPGQVFSREELLEQVWGYRHAADTRLVNVHVQRLRAKIERDPEN 204

                        170
                 ....*....|...
gi 490329716 212 --LIGTVRNVGYR 222
Cdd:NF040689 205 peIVVTVRGVGYK 217
CadC1 COG3710
DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];
131-231 1.80e-21

DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];


Pssm-ID: 442924 [Multi-domain]  Cd Length: 106  Bit Score: 85.73  E-value: 1.80e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716 131 IRSGDLVVDTNGYTANLRGVPIDLAYKEFELLKYLVQHPGRVFTRAQLLQEVWGyDYYGGTRTVDVHVRRLRAKLG--GE 208
Cdd:COG3710    3 YRFGDFRLDPARRELLRDGEPVRLSPRAFDLLLLLLEHPGRVVSRDELLAAVWP-GRVVSDNSLTQAISRLRKALGddGL 81

                         90       100
                 ....*....|....*....|...
gi 490329716 209 YEHLIGTVRNVGYRFDPPEEESA 231
Cdd:COG3710   82 EPRLIRTVPRRGYRLVAPVEVEA 104
PRK09836 PRK09836
DNA-binding transcriptional activator CusR; Provisional
 54-229 3.00e-19

DNA-binding transcriptional activator CusR; Provisional


Pssm-ID: 182102 [Multi-domain]  Cd Length: 227  Bit Score: 83.44  E-value: 3.00e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716  54 LCRLLHASGLSTPIVLILTEGGFT--VVNGEWGVSDVIVNTASPAEVEGRLRLVTERVATynVMPnalansgpedeDGLI 131
Cdd:PRK09836  62 IVRMLRSANKGMPILLLTALGTIEhrVKGLELGADDYLVKPFAFAELLARVRTLLRRGAA--VII-----------ESQF 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716 132 RSGDLVVDTNGYTANLRGVPIDLAYKEFELLKYLVQHPGRVFTRAQLLQEVWGYDYYGGTRTVDVHVRRLRAKLGGEYE- 210
Cdd:PRK09836 129 QVADLMVDLVSRKVTRSGTRITLTSKEFTLLEFFLRHQGEVLPRSLIASQVWDMNFDSDTNAIDVAVKRLRGKIDNDFEp 208

                        170
                 ....*....|....*....
gi 490329716 211 HLIGTVRNVGYRFDPPEEE 229
Cdd:PRK09836 209 KLIQTVRGVGYMLEVPDGQ 227
 
Name Accession Description Interval E-value
trans_reg_C cd00383
DNA-binding effector domain of two-component system response regulators; Bacteria and some ...
 136-223 2.24e-35

DNA-binding effector domain of two-component system response regulators; Bacteria and some eukaryotes use two-component signal transduction systems to detect and respond to changes in the environment. The systems consists of a sensor histidine kinase and a response regulator. The former autophosphorylates a histidine residue on detecting an external stimulus. The phosphate is then transferred to an invariant aspartate residue in a highly conserved receiver domain of the response regulator. Phosphorylation activates a variable effector domain of the response regulator, which triggers the cellular response. This C-terminal effector domain belongs to the winged helix-turn-helix family of transcriptional regulators and contains DNA and RNA polymerase binding sites. Several dimers or monomers bind head to tail to small tandem repeats upstream of the genes. The RNA polymerase binding sites interact with the alpha or sigma subunit of RNA polymerase.


Pssm-ID: 294013 [Multi-domain]  Cd Length: 89  Bit Score: 121.43  E-value: 2.24e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716 136 LVVDTNGYTANLRGVPIDLAYKEFELLKYLVQHPGRVFTRAQLLQEVWGYDYYGGTRTVDVHVRRLRAKLGGEYEH-LIG 214
Cdd:cd00383    1 LRLDPARREVTVDGEEVELTPKEFELLELLARNPGRVVSREELLEAVWGYDYEVDDRTVDVHISRLRKKLEDDPEPrLIK 80


                 ....*....
gi 490329716 215 TVRNVGYRF 223
Cdd:cd00383   81 TVRGVGYRL 89
PhoB TIGR02154
phosphate regulon transcriptional regulatory protein PhoB; PhoB is a DNA-binding response ...
 27-224 1.57e-33

phosphate regulon transcriptional regulatory protein PhoB; PhoB is a DNA-binding response regulator protein acting with PhoR in a 2-component system responding to phosphate ion. PhoB acts as a positive regulator of gene expression for phosphate-related genes such as phoA, phoS, phoE and ugpAB as well as itself. It is often found proximal to genes for the high-affinity phosphate ABC transporter (pstSCAB; GenProp0190) and presumably regulates these as well. [Regulatory functions, DNA interactions, Signal transduction, Two-component systems]


Pssm-ID: 131209 [Multi-domain]  Cd Length: 226  Bit Score: 120.90  E-value: 1.57e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716   27 DASSLVRMPENTILLLDARDDLASAKTLCRLLHASGLSTPI-VLILTEGGFTV--VNG-EWGVSDVIVNTASPAEVEGRL 102
Cdd:TIGR02154  37 EALTLINERGPDLILLDWMLPGTSGIELCRRLRRRPETRAIpIIMLTARGEEEdrVRGlETGADDYITKPFSPRELLARI 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716  103 RLVTERvatynvmpnalanSGPEDEDGLIRSGDLVVDTNGYTANLRGVPIDLAYKEFELLKYLVQHPGRVFTRAQLLQEV 182
Cdd:TIGR02154 117 KAVLRR-------------IRPQLSDEVIEVGDLSLDPVAHRVFRGGQPLSLGPTEFRLLHFFMTHPERVYSREQLLDRV 183

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 490329716  183 WGYDYYGGTRTVDVHVRRLRAKLGGE-YEHLIGTVRNVGYRFD 224
Cdd:TIGR02154 184 WGRDVYVEERTVDVHIRRLRKALNPFgLEDPVQTVRGAGYRFS 226
Trans_reg_C pfam00486
Transcriptional regulatory protein, C terminal;
149-223 4.62e-33

Transcriptional regulatory protein, C terminal;


Pssm-ID: 425712 [Multi-domain]  Cd Length: 77  Bit Score: 114.92  E-value: 4.62e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490329716  149 GVPIDLAYKEFELLKYLVQHPGRVFTRAQLLQEVWGYDYYGGTRTVDVHVRRLRAKLG--GEYEHLIGTVRNVGYRF 223
Cdd:pfam00486   1 GEEVELTPKEFKLLELLAENPGRVVSREQLLEEVWGEDYDVDDNTVDVHISRLRKKLEddPRDPRLIKTVRGVGYRL 77
Trans_reg_C smart00862
Transcriptional regulatory protein, C terminal; This domain is almost always found associated ...
 149-223 4.57e-32

Transcriptional regulatory protein, C terminal; This domain is almost always found associated with the response regulator receiver domain. It may play a role in DNA binding.


Pssm-ID: 214866 [Multi-domain]  Cd Length: 76  Bit Score: 112.26  E-value: 4.57e-32
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490329716   149 GVPIDLAYKEFELLKYLVQHPGRVFTRAQLLQEVWGYDYYGGTRTVDVHVRRLRAKLG-GEYEHLIGTVRNVGYRF 223
Cdd:smart00862   1 GEPIKLTPKEFRLLELLLRNPGRVVSREELLEAVWGDDEDVDDNTLDVHISRLRKKLEdDGDPRLIETVRGVGYRL 76
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 53-209 5.24e-30

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 111.20  E-value: 5.24e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716  53 TLCRLLHASGLSTPIvLILTEGG--FTVVNG-EWGVSDVIVNTASPAEVEGRLRLVTERVATynvmpnalansgpededG 129
Cdd:COG0745   62 EVCRRLRARPSDIPI-IMLTARDdeEDRVRGlEAGADDYLTKPFDPEELLARIRALLRRRAA-----------------E 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716 130 LIRSGDLVvDTNGYTANLRGVPIDLAYKEFELLKYLVQHPGRVFTRAQLLQEVWGYDyYGGTRTVDVHVRRLRAKLGGEY 209
Cdd:COG0745  124 VLRVGDLL-DLAAREVTRDGEPVELTPKEFRLLELLMRNPGRVVSREQLLEEVWGYD-YGDDRTVDVHISRLRKKLEDDL 201
resp_reg_YycF NF040534
response regulator YycF;
125-227 5.87e-30

response regulator YycF;


Pssm-ID: 439744 [Multi-domain]  Cd Length: 231  Bit Score: 111.74  E-value: 5.87e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716 125 EDEDGLIRSGDLVVDTNGYTANLRGVPIDLAYKEFELLKYLVQHPGRVFTRAQLLQEVWGYDYYGGTRTVDVHVRRLRAK 204
Cdd:NF040534 127 EEENNEIVIGSLTIHPDAYTVKKRGETIELTHREFELLHYLAKHIGQVMTREHLLQTVWGYDYFGDVRTVDVTVRRLREK 206

                         90       100
                 ....*....|....*....|....*
gi 490329716 205 LGGEYEH--LIGTVRNVGYRFDPPE 227
Cdd:NF040534 207 IEDNPSHpeWIVTRRGVGYYLRNPE 231
orf27 CHL00148
Ycf27; Reviewed
 82-223 8.44e-29

Ycf27; Reviewed


Pssm-ID: 214376 [Multi-domain]  Cd Length: 240  Bit Score: 109.04  E-value: 8.44e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716  82 EWGVSDVIVNTASPAEVEGRLRLVTERVatynvmpNALANSGPEDEDGLIRSGDLVVDTNGYTANLRGVPIDLAYKEFEL 161
Cdd:CHL00148  97 ELGADDYVVKPFSPKELEARIRSVLRRT-------NKKSFSSKIPNSSIIRIGFLKIDLNKKQVYKNNERIRLTGMEFSL 169

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490329716 162 LKYLVQHPGRVFTRAQLLQEVWGYDY--YGGTRTVDVHVRRLRAKLGGEYEH--LIGTVRNVGYRF 223
Cdd:CHL00148 170 LELLISKSGEIFSRATILKEVWGYTPerHIDTRVVDVHISRLRAKLEDDPSNpdLILTARGTGYLF 235
MtrAB_MtrA NF040689
MtrAB system response regulator MtrA;
55-222 6.85e-28

MtrAB system response regulator MtrA;


Pssm-ID: 468653 [Multi-domain]  Cd Length: 219  Bit Score: 106.11  E-value: 6.85e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716  55 CRLLHASGlSTPIVLiLTEGGFT--VVNG-EWGVSDVIVNTASPAEVEGRLRLVTERVAtynvmpnalansgpEDEDGLI 131
Cdd:NF040689  61 CRQIRAES-GVPIIM-LTAKSDTvdVVRGlEAGADDYVVKPFKPKELVARIRARLRRSE--------------DEESEVL 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716 132 RSGDLVVDTNGYTANLRGVPIDLAYKEFELLKYLVQHPGRVFTRAQLLQEVWGYDYYGGTRTVDVHVRRLRAKLGGEYEH 211
Cdd:NF040689 125 RIGDLTIDVAGHEVTRGGEEIPLTPLEFDLLVALARKPGQVFSREELLEQVWGYRHAADTRLVNVHVQRLRAKIERDPEN 204

                        170
                 ....*....|...
gi 490329716 212 --LIGTVRNVGYR 222
Cdd:NF040689 205 peIVVTVRGVGYK 217
PRK11083 PRK11083
DNA-binding response regulator CreB; Provisional
 54-225 1.44e-22

DNA-binding response regulator CreB; Provisional


Pssm-ID: 236838 [Multi-domain]  Cd Length: 228  Bit Score: 91.95  E-value: 1.44e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716  54 LCRLLHASGLSTPiVLILT---EGGFTVVNGEWGVSDVIVNTASPAEVEGRLRLVTERVAtynvmPNALANSGPededgl 130
Cdd:PRK11083  65 LCRQLLAFHPALP-VIFLTarsDEVDRLVGLEIGADDYVAKPFSPREVAARVRTILRRVK-----KFAAPSPVI------ 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716 131 iRSGDLVVDTNGYTANLRGVPIDLAYKEFELLKYLVQHPGRVFTRAQLLQEVWGYDYYGGTRTVDVHVRRLRAKLGGEYE 210
Cdd:PRK11083 133 -RIGHFELDEPAARISYFGTPLTLTRYEFLLLKTLLLSPGRVFSRQQLMDIVWEDAQDSYDRTVDTHIKTLRAKLRAINP 211

                        170
                 ....*....|....*..
gi 490329716 211 HL--IGTVRNVGYRFDP 225
Cdd:PRK11083 212 DLspINTHRGMGYSLRP 228
CadC1 COG3710
DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];
131-231 1.80e-21

DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];


Pssm-ID: 442924 [Multi-domain]  Cd Length: 106  Bit Score: 85.73  E-value: 1.80e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716 131 IRSGDLVVDTNGYTANLRGVPIDLAYKEFELLKYLVQHPGRVFTRAQLLQEVWGyDYYGGTRTVDVHVRRLRAKLG--GE 208
Cdd:COG3710    3 YRFGDFRLDPARRELLRDGEPVRLSPRAFDLLLLLLEHPGRVVSRDELLAAVWP-GRVVSDNSLTQAISRLRKALGddGL 81

                         90       100
                 ....*....|....*....|...
gi 490329716 209 YEHLIGTVRNVGYRFDPPEEESA 231
Cdd:COG3710   82 EPRLIRTVPRRGYRLVAPVEVEA 104
PRK10161 PRK10161
phosphate response regulator transcription factor PhoB;
66-223 1.45e-20

phosphate response regulator transcription factor PhoB;


Pssm-ID: 182277 [Multi-domain]  Cd Length: 229  Bit Score: 87.08  E-value: 1.45e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716  66 PIVLILTEGGFT--VVNGEWGVSDVIVNTASPAEVEGRLRLVTERVAtynvmpnalansgPEDEDGLIRSGDLVVDTNGY 143
Cdd:PRK10161  78 PVVMLTARGEEEdrVRGLETGADDYITKPFSPKELVARIKAVMRRIS-------------PMAVEEVIEMQGLSLDPTSH 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716 144 TANLRGVPIDLAYKEFELLKYLVQHPGRVFTRAQLLQEVWGYDYYGGTRTVDVHVRRLRAKLGGE-YEHLIGTVRNVGYR 222
Cdd:PRK10161 145 RVMAGEEPLEMGPTEFKLLHFFMTHPERVYSREQLLNHVWGTNVYVEDRTVDVHIRRLRKALEPGgHDRMVQTVRGTGYR 224


                 .
gi 490329716 223 F 223
Cdd:PRK10161 225 F 225
PRK09836 PRK09836
DNA-binding transcriptional activator CusR; Provisional
 54-229 3.00e-19

DNA-binding transcriptional activator CusR; Provisional


Pssm-ID: 182102 [Multi-domain]  Cd Length: 227  Bit Score: 83.44  E-value: 3.00e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716  54 LCRLLHASGLSTPIVLILTEGGFT--VVNGEWGVSDVIVNTASPAEVEGRLRLVTERVATynVMPnalansgpedeDGLI 131
Cdd:PRK09836  62 IVRMLRSANKGMPILLLTALGTIEhrVKGLELGADDYLVKPFAFAELLARVRTLLRRGAA--VII-----------ESQF 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716 132 RSGDLVVDTNGYTANLRGVPIDLAYKEFELLKYLVQHPGRVFTRAQLLQEVWGYDYYGGTRTVDVHVRRLRAKLGGEYE- 210
Cdd:PRK09836 129 QVADLMVDLVSRKVTRSGTRITLTSKEFTLLEFFLRHQGEVLPRSLIASQVWDMNFDSDTNAIDVAVKRLRGKIDNDFEp 208

                        170
                 ....*....|....*....
gi 490329716 211 HLIGTVRNVGYRFDPPEEE 229
Cdd:PRK09836 209 KLIQTVRGVGYMLEVPDGQ 227
PRK10710 PRK10710
DNA-binding transcriptional regulator BaeR; Provisional
 40-224 1.58e-18

DNA-binding transcriptional regulator BaeR; Provisional


Pssm-ID: 182665 [Multi-domain]  Cd Length: 240  Bit Score: 81.66  E-value: 1.58e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716  40 LLLDARDDLasakTLCRLLHasGLS-TPIVLIL--TEGGFTVVNGEWGVSDVIVNTASPAEVEGRLRLVTERVatynvmp 116
Cdd:PRK10710  62 LMLPGTDGL----TLCREIR--RFSdIPIVMVTakIEEIDRLLGLEIGADDYICKPYSPREVVARVKTILRRC------- 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716 117 nalanSGPEDEDGLIRSGDLVVDTNGYTANLRGVPIDLAYKEFELLKYLVQHPGRVFTRAQLLQEVwgYDYYG--GTRTV 194
Cdd:PRK10710 129 -----KPQRELQQQDAESPLIIDESRFQASWRGKMLDLTPAEFRLLKTLSHEPGKVFSREQLLNHL--YDDYRvvTDRTI 201

                        170       180       190
                 ....*....|....*....|....*....|..
gi 490329716 195 DVHVRRLRAKLGG--EYEHLIGTVRNVGYRFD 224
Cdd:PRK10710 202 DSHIKNLRRKLESldAEQSFIRAVYGVGYRWE 233
PRK10701 PRK10701
DNA-binding transcriptional regulator RstA; Provisional
 53-225 3.62e-17

DNA-binding transcriptional regulator RstA; Provisional


Pssm-ID: 236738 [Multi-domain]  Cd Length: 240  Bit Score: 77.75  E-value: 3.62e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716  53 TLCRLLHASgLSTPIVLI--LTEGGFTVVNGEWGVSDVIVNTASPAEVEGRLRLVTeRVATYNVMPNALANSGPEDEDGL 130
Cdd:PRK10701  62 TICRDLRPK-WQGPIVLLtsLDSDMNHILALEMGACDYILKTTPPAVLLARLRLHL-RQNEQATQTKGLQETSLTPYKAL 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716 131 iRSGDLVVDTNGYTANLRGVPIDLAYKEFELLKYLVQHPGRVFTRAQLLQEVWGYDYYGGTRTVDVHVRRLRAKLG--GE 208
Cdd:PRK10701 140 -HFGTLTIDPVNRQVTLAGEEISLSTADFDLLWELATHAGQIMDRDALLKNLRGVSYDGLDRSVDVAISRLRKKLLdnAA 218

                        170
                 ....*....|....*..
gi 490329716 209 YEHLIGTVRNVGYRFDP 225
Cdd:PRK10701 219 EPYRIKTVRNKGYLFAP 235
PRK11517 PRK11517
DNA-binding response regulator HprR;
135-228 9.59e-16

DNA-binding response regulator HprR;


Pssm-ID: 183172 [Multi-domain]  Cd Length: 223  Bit Score: 73.78  E-value: 9.59e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716 135 DLVVDTNGYTANLRGVPIDLAYKEFELLKYLVQHPGRVFTRAQLLQEVWGYDYYGGTRTVDVHVRRLRAKLGGEYE-HLI 213
Cdd:PRK11517 129 GLRMDSVSQSVSRDNISITLTRKEFQLLWLLASRAGEIIPRTVIASEIWGINFDSDTNTVDVAIRRLRAKVDDPFPeKLI 208

                         90
                 ....*....|....*
gi 490329716 214 GTVRNVGYRFDPPEE 228
Cdd:PRK11517 209 ATIRGMGYSFVAVKK 223
ompR PRK09468
osmolarity response regulator; Provisional
 40-225 1.69e-12

osmolarity response regulator; Provisional


Pssm-ID: 181883 [Multi-domain]  Cd Length: 239  Bit Score: 65.00  E-value: 1.69e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716  40 LLLDARDDLasakTLCRLLHASGLSTPIVLiLTEGGFTV---VNGEWGVSDVIVNTASPAEVEGRLRLVTERVATynVMP 116
Cdd:PRK09468  57 LMLPGEDGL----SICRRLRSQNNPTPIIM-LTAKGEEVdriVGLEIGADDYLPKPFNPRELLARIRAVLRRQAP--ELP 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716 117 NAlansgPEDEDGLIRSGDLVVDTNGYTANLRGVPIDLAYKEFELLKYLVQHPGRVFTRAQLLQEVWGYDYYGGTRTVDV 196
Cdd:PRK09468 130 GA-----PSQEEEVIAFGKFKLNLGTRELFRGDEPMPLTTGEFAVLKALVSHPREPLSRDKLMNLARGREYSAMERSIDV 204

                        170       180       190
                 ....*....|....*....|....*....|.
gi 490329716 197 HVRRLRAKLGGEYEH--LIGTVRNVGYRFDP 225
Cdd:PRK09468 205 QISRLRRLIEEDPAHprYIQTVWGLGYVFVP 235
PRK10643 PRK10643
two-component system response regulator PmrA;
128-229 3.00e-12

two-component system response regulator PmrA;


Pssm-ID: 182612 [Multi-domain]  Cd Length: 222  Bit Score: 63.90  E-value: 3.00e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716 128 DGLIRSGDLVVDTNGYTANLRGVPIDLAYKEFELLKYLVQHPGRVFTRAQLLQEVWGYDYYGGTRTVDVHVRRLRAKLGG 207
Cdd:PRK10643 124 ENELQVGNLTLNLGRQQVWLDGQELILTPKEFALLSRLMLKAGSPVHREILYQDIYNWDDEPSSNTLEVHIHNLRDKVGK 203

                         90       100
                 ....*....|....*....|..
gi 490329716 208 EYehlIGTVRNVGYRFDPPEEE 229
Cdd:PRK10643 204 DR---IRTVRGFGYMLVANEEN 222
PRK10336 PRK10336
two-component system response regulator QseB;
131-221 1.66e-11

two-component system response regulator QseB;


Pssm-ID: 182387 [Multi-domain]  Cd Length: 219  Bit Score: 61.83  E-value: 1.66e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716 131 IRSGDLVVDTNGYTANLRGVPIDLAYKEFELLKYLVQHPGRVFTRAQLLQEVWGYDYYGGTRTVDVHVRRLRAKLGGEYe 210
Cdd:PRK10336 127 LRHGNVMLDPGKRIATLAGEPLTLKPKEFALLELLMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDF- 205

                         90
                 ....*....|.
gi 490329716 211 hlIGTVRNVGY 221
Cdd:PRK10336 206 --IRTVHGIGY 214
PRK10766 PRK10766
two-component system response regulator TorR;
125-205 2.53e-10

two-component system response regulator TorR;


Pssm-ID: 182711 [Multi-domain]  Cd Length: 221  Bit Score: 58.51  E-value: 2.53e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716 125 EDEDGLIRSGDLVVDTNGYTANLRGVPIDLAYKEFELLKYLVQHPGRVFTRAQLLQEVWGYDYYGGTRTVDVHVRRLRAK 204
Cdd:PRK10766 131 QEEDNCYRFAGYCLNVSRRTLERNGEPIKLTKAEYELLVAFVTNPGQVLSRERLLRMLSHRVENPNDRTIDVLIRRLRHK 210


                 .
gi 490329716 205 L 205
Cdd:PRK10766 211 L 211
PRK10529 PRK10529
DNA-binding transcriptional activator KdpE; Provisional
 97-225 9.02e-10

DNA-binding transcriptional activator KdpE; Provisional


Pssm-ID: 182522 [Multi-domain]  Cd Length: 225  Bit Score: 57.12  E-value: 9.02e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716  97 EVEGRLRLVTERvatynvmpnalaNSGPEDEDGLIRSGDLVVDTNGYTANLRGVPIDLAYKEFELLKYLVQHPGRVFTRA 176
Cdd:PRK10529 107 ELQARLRVALRR------------HSATPAPDPLVKFSDVTVDLAARVIHRGEEEVHLTPIEFRLLAVLLNNAGKVLTQR 174

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 490329716 177 QLLQEVWGYDYYGGTRTVDVHVRRLRAKLGGE---YEHLIgTVRNVGYRFDP 225
Cdd:PRK10529 175 QLLNQVWGPNAVEHSHYLRIYMGHLRQKLEQDparPRHFI-TETGIGYRFMP 225
PRK11173 PRK11173
two-component response regulator; Provisional
 82-223 3.16e-09

two-component response regulator; Provisional


Pssm-ID: 183013 [Multi-domain]  Cd Length: 237  Bit Score: 55.79  E-value: 3.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716  82 EWGVSDVIVNTASPAEVEGRLRlvtervatyNVMPNALANSGPEDEDGLIRSgdlvVDTNGYT--ANLR------GVPID 153
Cdd:PRK11173  94 EIGADDYITKPFNPRELTIRAR---------NLLSRTMNLGTVSEERRSVES----YKFNGWEldINSRslispdGEQYK 160

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490329716 154 LAYKEFELLKYLVQHPGRVFTRAQLLQEVWGYDYYGGTRTVDVHVRRLRA--KLGGEYEHLIGTVRNVGYRF 223
Cdd:PRK11173 161 LPRSEFRAMLHFCENPGKIQSRAELLKKMTGRELKPHDRTVDVTIRRIRKhfESTPDTPEIIATIHGEGYRF 232
PRK10955 PRK10955
envelope stress response regulator transcription factor CpxR;
65-221 1.02e-07

envelope stress response regulator transcription factor CpxR;


Pssm-ID: 182864 [Multi-domain]  Cd Length: 232  Bit Score: 51.34  E-value: 1.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716  65 TPIVLILTEGGF--TVVNGEWGVSDVIVNTASPAEVEGRLRLVTERVATYNVMPNALANSGPEDEDGLirsgdlVVDTNG 142
Cdd:PRK10955  72 TPVIMLTARGSEldRVLGLELGADDYLPKPFNDRELVARIRAILRRSHWSEQQQNNDNGSPTLEVDAL------SLNPGR 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716 143 YTANLRGVPIDLAYKEFELLKYLVQHPGRVFTRAQLLQEVWGYDYYGGTRTVDVHVRRLRAKLGGEYEHL--IGTVRNVG 220
Cdd:PRK10955 146 QEASFDGQTLELTGTEFTLLYLLAQHLGQVVSREHLSQEVLGKRLTPFDRAIDMHISNLRRKLPDRKDGHpwFKTLRGRG 225


                 .
gi 490329716 221 Y 221
Cdd:PRK10955 226 Y 226
DnrI COG3629
DNA-binding transcriptional regulator DnrI/AfsR/EmbR, SARP family, contains BTAD domain ...
 149-229 3.49e-05

DNA-binding transcriptional regulator DnrI/AfsR/EmbR, SARP family, contains BTAD domain [Transcription];


Pssm-ID: 442847 [Multi-domain]  Cd Length: 244  Bit Score: 43.68  E-value: 3.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716 149 GVPIDLAY-KEFELLKYLVQHPGRVFTRAQLLQEVWGYDYYGGTR-TVDVHVRRLRAKLGGEYEHLIGTVRNvGYRFDPP 226
Cdd:COG3629   16 GRPVPLGGpKQRALLAYLALRAGRPVSRDRLADLLWGDDPPASARaNLRTYVSRLRRALGPAGGDLLVTRGG-GYRLDVD 94


                 ...
gi 490329716 227 EEE 229
Cdd:COG3629   95 PDE 97
PRK10816 PRK10816
two-component system response regulator PhoP;
149-224 4.29e-05

two-component system response regulator PhoP;


Pssm-ID: 182755 [Multi-domain]  Cd Length: 223  Bit Score: 43.19  E-value: 4.29e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490329716 149 GVPIDLAYKEFELLKYLVQHPGRVFTRAQLLQEVWGYDYYGGTRTVDVHVRRLRAKLGGEYEH-LIGTVRNVGYRFD 224
Cdd:PRK10816 145 DEVIKLTAFEYTIMETLIRNNGKVVSKDSLMLQLYPDAELRESHTIDVLMGRLRKKIQAQYPQeVITTVRGQGYRFD 221
PRK13856 PRK13856
two-component response regulator VirG; Provisional
 142-224 6.96e-05

two-component response regulator VirG; Provisional


Pssm-ID: 172377 [Multi-domain]  Cd Length: 241  Bit Score: 42.88  E-value: 6.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716 142 GYTANLR--------GVPIDLAYKEFELLKYLVQHPGRVFTRAQLL--QEVWGYDYYggTRTVDVHVRRLRAKLGGE--Y 209
Cdd:PRK13856 136 DWTLNLRqrrliseaGGEVKLTAGEFNLLVAFLEKPRDVLSREQLLiaSRVREEEVY--DRSIDVLILRLRRKLEQDpaN 213

                         90
                 ....*....|....*
gi 490329716 210 EHLIGTVRNVGYRFD 224
Cdd:PRK13856 214 PQLIKTARGAGYFFD 228
PRK07239 PRK07239
bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated
 131-222 4.93e-04

bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated


Pssm-ID: 235981 [Multi-domain]  Cd Length: 381  Bit Score: 40.73  E-value: 4.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490329716 131 IRSGDLVVDtngytanlrGVPIDLAYKEFELLKYLVQHPGRVFTRAQLLQEVWGydyyGG--TRTVDVHVRRLRAKLGGe 208
Cdd:PRK07239 293 IRGHAVVVD---------GEVKPLSPAPMALLRALAARPGRVVSREDLLAALPG----GGtdEHAVETAVARLRTALGD- 358

                         90
                 ....*....|....
gi 490329716 209 yEHLIGTVRNVGYR 222
Cdd:PRK07239 359 -PKLVQTVVKRGYR 371
PRK10153 PRK10153
DNA-binding transcriptional activator CadC; Provisional
 161-183 3.51e-03

DNA-binding transcriptional activator CadC; Provisional


Pssm-ID: 236658 [Multi-domain]  Cd Length: 517  Bit Score: 38.10  E-value: 3.51e-03
                         10        20
                 ....*....|....*....|...
gi 490329716 161 LLKYLVQHPGRVFTRAQLLQEVW 183
Cdd:PRK10153  36 LLVFFAQHSGEVLSRDELIDHVW 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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