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Conserved domains on  [gi|490252713|ref|WP_004150739|]
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MULTISPECIES: HHA domain-containing protein [Enterobacterales]

Protein Classification

HHA domain-containing protein( domain architecture ID 10013682)

HHA domain-containing protein similar to hemolysin expression-modulating protein Hha may play a role in the regulation of gene expression in response to environmental factors

CATH:  1.20.1280.40
PubMed:  15458420
SCOP:  4002903

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10945 PRK10945
hemolysin expression modulator Hha;
1-67 2.59e-39

hemolysin expression modulator Hha;


:

Pssm-ID: 182856  Cd Length: 72  Bit Score: 123.82  E-value: 2.59e-39
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490252713  1 MTKQEWILRLRRCTSKETLERVIEKNKYSLSDDELEHFNAAVDHRLAEMAMGKFYDKIPAGVWKYVK 67
Cdd:PRK10945  6 LTKTDYLMRLRRCQTIDTLERVIEKNKYELSDDELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR 72
 
Name Accession Description Interval E-value
PRK10945 PRK10945
hemolysin expression modulator Hha;
1-67 2.59e-39

hemolysin expression modulator Hha;


Pssm-ID: 182856  Cd Length: 72  Bit Score: 123.82  E-value: 2.59e-39
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490252713  1 MTKQEWILRLRRCTSKETLERVIEKNKYSLSDDELEHFNAAVDHRLAEMAMGKFYDKIPAGVWKYVK 67
Cdd:PRK10945  6 LTKTDYLMRLRRCQTIDTLERVIEKNKYELSDDELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR 72
HHA pfam05321
Haemolysin expression modulating protein; This family consists of haemolysin expression ...
 8-63 1.41e-24

Haemolysin expression modulating protein; This family consists of haemolysin expression modulating protein (HHA) homologs. YmoA and Hha are highly similar bacterial proteins downregulating gene expression in Yersinia enterocolitica and Escherichia coli, respectively.


Pssm-ID: 428422  Cd Length: 56  Bit Score: 86.13  E-value: 1.41e-24
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 490252713   8 LRLRRCTSKETLERVIEKNKYSLSDDELEHFNAAVDHRLAEMAMGKFYDKIPAGVW 63
Cdd:pfam05321  1 MRLRRCSSIDTLEKVIEKNKYELTNDELSSFYSAADHRLAELTMGKLYDKIPKSVW 56
 
Name Accession Description Interval E-value
PRK10945 PRK10945
hemolysin expression modulator Hha;
1-67 2.59e-39

hemolysin expression modulator Hha;


Pssm-ID: 182856  Cd Length: 72  Bit Score: 123.82  E-value: 2.59e-39
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490252713  1 MTKQEWILRLRRCTSKETLERVIEKNKYSLSDDELEHFNAAVDHRLAEMAMGKFYDKIPAGVWKYVK 67
Cdd:PRK10945  6 LTKTDYLMRLRRCQTIDTLERVIEKNKYELSDDELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR 72
HHA pfam05321
Haemolysin expression modulating protein; This family consists of haemolysin expression ...
 8-63 1.41e-24

Haemolysin expression modulating protein; This family consists of haemolysin expression modulating protein (HHA) homologs. YmoA and Hha are highly similar bacterial proteins downregulating gene expression in Yersinia enterocolitica and Escherichia coli, respectively.


Pssm-ID: 428422  Cd Length: 56  Bit Score: 86.13  E-value: 1.41e-24
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 490252713   8 LRLRRCTSKETLERVIEKNKYSLSDDELEHFNAAVDHRLAEMAMGKFYDKIPAGVW 63
Cdd:pfam05321  1 MRLRRCSSIDTLEKVIEKNKYELTNDELSSFYSAADHRLAELTMGKLYDKIPKSVW 56
PRK10391 PRK10391
transcription modulator YdgT;
1-66 1.37e-11

transcription modulator YdgT;


Pssm-ID: 182426  Cd Length: 71  Bit Score: 53.66  E-value: 1.37e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490252713  1 MTKQEWILRLRRCTSKETLERVIEKNKYSLSDD-ELEHFNAAVDHRLAEMAM-GKFYD--KIPAGVWKYV 66
Cdd:PRK10391  1 MTVQDYLLKFRKISSLESLEKLFDHLNYTLTDDqEIINMYRAADHRRAELVSgGRLFDlgQVPKSVWHYV 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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