|
Name |
Accession |
Description |
Interval |
E-value |
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
14-452 |
2.63e-110 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 332.64 E-value: 2.63e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 14 IGVKEKIGYGFGDFASNLSFGFVSLFLLFFYTNIYGISAVQASLIFVIARVVDAAFNIVIGFAIDKTHSRYGKLRPWLLY 93
Cdd:COG2211 7 LSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGRRRPWILI 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 94 GSIPLGFLTVLCFV--PFGGEAKFYFALISYTIYCLAYTAVNTPYSALTNRLTQHEASRSSLSVYRFVLAIVGYLIVSTT 171
Cdd:COG2211 87 GAIPLALSFVLLFTapDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGLLASVL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 172 ADRLISPFS-DKQLGYVFAVSCFALLATFLFLACFGMTKERVGEEEEQTPaptLREMLKAVAGNAPLINLSMFTVFFYIA 250
Cdd:COG2211 167 PPPLVAAFGgDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVS---LKESLKALLKNRPFLLLLLAYLLFFLA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 251 YTVWMAIAIYFIKYIIG-SEGFTSTFFMIQSAAYIVGTVISEKIIALIGKKKMTLVALLIGVVGVLMQYFIAGDNIWLIM 329
Cdd:COG2211 244 LALVAALLLYYFKYVLGlSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLL 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 330 TGVCLYSITLGMGFVSMWSMIADTVEYAEWHHGVRTEGAIYGFFNFITKIAMAIGGGCAGWMLDYYHYDAG-NITASAIN 408
Cdd:COG2211 324 VLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAGaAQSPSALT 403
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 490241292 409 GINVLMTLFPGAMFALSALFVACYSLDEKTYRDIVQKISLRKQN 452
Cdd:COG2211 404 GIRLLFFLLPAVLLLLAALLLLFYPLTRERHAEIRAELAARRAA 447
|
|
| gph |
TIGR00792 |
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH): ... |
19-446 |
2.75e-97 |
|
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family (TC 2.A.2) GPH:cation symporters catalyze uptake of sugars in symport with a monovalent cation (H+ or Na+). Members of this family includes transporters for melibiose, lactose, raffinose, glucuronides, pentosides and isoprimeverose. Mutants of two groups of these symporters (the melibiose permeases of enteric bacteria, and the lactose permease of Streptococcus thermophilus) have been isolated in which altered cation specificity is observed or in which sugar transport is uncoupled from cation symport (i.e., uniport is catalyzed). The various members of the family can use Na+, H+ or Li, Na+ or Li+, H+ or Li+, or only H+ as the symported cation. All of these proteins possess twelve putative transmembrane a-helical spanners. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273270 Cd Length: 437 Bit Score: 299.17 E-value: 2.75e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 19 KIGYGFGDFASNLSFGFVSLFLLFFYTNIYGISAVQASLIFVIARVVDAAFNIVIGFAIDKTHSRYGKLRPWLLYGSIPL 98
Cdd:TIGR00792 1 KLSYGFGDFGNDFIFAIVSTYLLFFYTDVLGLSAAFVGTLFLVARILDAITDPIMGNIVDRTRTRWGKFRPWLLIGAIPF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 99 GFLTVLCFV--PFGGEAKFYFALISYTIYCLAYTAVNTPYSALTNRLTQHEASRSSLSVYRFVLAIVGYLIVSTTADRLI 176
Cdd:TIGR00792 81 SIVLVLLFTtpDFSGTGKLVYAYITYILLGLFYSFVNIPYWSLVPAITLDPRERESLSTFRRFGATLGGLLVAVIVLPLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 177 SPFS--DKQLGYVFAVSCFALLATFLFLACFGMTKERVGEEEEQ-TPAPTLREMLKAVAGNAPLINLSMFTVFFYIAYTV 253
Cdd:TIGR00792 161 SYFGggDDKFGWFMFALVLALIGVVSLIICFFGTKERYSEIPKNiEKKLSLKQIFKALFKNDQLLILCLAYLFYNLAFNI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 254 WMAIAIYFIKYIIGSEGFTSTFFMIQSAAYIVGTVISEKIIALIGKKKMTLVALLIGVVGVLMqYFIAGDNIWLIMTGVC 333
Cdd:TIGR00792 241 KNGVQVYYFTYVLGDPELFSYMGSIAIVAGLIGVLLFPRLVKKFGRKILFAGGILLMVLGYLI-FFFAGSNLPLILVLII 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 334 LYSITLGMGFVSMWSMIADTVEYAEWHHGVRTEGAIYGFFNFITKIAMAIGGGCAGWMLDYYHYDAGNI-TASAINGINV 412
Cdd:TIGR00792 320 LAGFGQNIVTGLVWALVADTVDYGEWKTGIRAEGLVYSVRTFVRKLGQALAGFFVGLILGIIGYVANAAqSPITLNGIKI 399
|
410 420 430
....*....|....*....|....*....|....*
gi 490241292 413 LMTLFPGAMFALSALFVAC-YSLDEKTYRDIVQKI 446
Cdd:TIGR00792 400 LMFAVPALFLLLAAIIIGRfYKLTEKKHAEIVEEL 434
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
19-436 |
1.16e-95 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 294.51 E-value: 1.16e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 19 KIGYGFGDFASNLSFGFVSLFLLFFYTNIYGISAVQASLIFVIARVVDAAFNIVIGFAIDKTHSRYGKLRPWLLYGSIPL 98
Cdd:cd17332 1 KIGYGLGDFGNNLIFQIVSTYLLFFYTDVLGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTRSRWGRFRPWLLWGAIPL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 99 GFLTVLCFVP--FGGEAKFYFALISYTIYCLAYTAVNTPYSALTNRLTQHEASRSSLSVYRFVLAIVGYLIVSTTADRLI 176
Cdd:cd17332 81 ALLFVLLFTTpdGSGTGKLIYALITYILLDLLYTLVNIPYTALIPELTDDPEERTSLTSWRMFFATIGGLLVTVLPPPLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 177 SPFS--DKQLGYVFAVSCFALLATFLFLACFGMTKERVGEEEEQTPAPTLREMLKAVAGNAPLINLSMFTVFFYIAYTVW 254
Cdd:cd17332 161 AYFGggNASRGYFLTALIIGIIGIILLLICFFGTRERVVPPEEEKSKLPLLKSLKALLKNRPFLILLLAYLLYFLAFNIV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 255 MAIAIYFIKYIIGSEGFTSTFFMIQSAAYIVGTVISEKIIALIGKKKMTLVALLIGVVGVLMQYFIAGDNIWLIMTGVCL 334
Cdd:cd17332 241 NTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPPGNLVLILVLAVL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 335 YSITLGMGFVSMWSMIADTVEYAEWHHGVRTEGAIYGFFNFITKIAMAIGGGCAGWMLDYYHYDAGN--ITASAINGINV 412
Cdd:cd17332 321 AGIGYGGANLLPWAMLADVIDYGELKTGKRREGIFYSVMTFFRKLGLALAGALVGLILSLAGYVANAaaQSASALNGIRL 400
|
410 420
....*....|....*....|....
gi 490241292 413 LMTLFPGAMFALSALFVACYSLDE 436
Cdd:cd17332 401 LIAVLPAVLLLLALILMSFYPLDK 424
|
|
| PRK09669 |
PRK09669 |
putative symporter YagG; Provisional |
13-444 |
6.28e-82 |
|
putative symporter YagG; Provisional
Pssm-ID: 236610 Cd Length: 444 Bit Score: 259.66 E-value: 6.28e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 13 VIGVKEKIGYGFGDFASNLSFGFVSLFLLFFYTNIYGISAVQASLIFVIARVVDAAFNIVIGFAIDKTHSRYGKLRPWLL 92
Cdd:PRK09669 5 QLTTKDKIGYGLGDTACNLVWQTVMLFLAYFYTDVFGLSAAIMGTMFLVVRVLDAVTDPLMGALVDRTRTRHGQFRPYLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 93 YGSIPLGFLTVLCF-VP-FGGEAKFYFALISYTIYCLAYTAVNTPYSALTNRLTQHEASRSSLSVYRFVLAIVGYLIVST 170
Cdd:PRK09669 85 WFAIPFGVVCLLTFyTPdFGATGKIIYACVTYILLSLVYTAINVPYCAMPGAITNDPRERHSLQSWRFALSFIGGLIVSV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 171 TADRLISPF--SDKQLGYVFAVSCFALLATFLFLACFGMTKERVGEEEEqtPAPTLREMLKAVAGNAPLINLSMFTVFFY 248
Cdd:PRK09669 165 IALPLVDILgkGDEQKGYFYAMMVMGLLGVVLFFCCFFMTKERYTPEVD--NSSSVWKDLKLLLGNSQWRIMFIFNVVLL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 249 IAYTVWMAIAIYFIKYIIGSEGFTSTFFMIQSAAYIVGTVISEKIIALIGKKKMTLVALLIGVVGVLMQYFIAGDNIWLI 328
Cdd:PRK09669 243 TAVVTRGGATLYYVNYVLLRPDLATLFLVTGMIAGLFGALLSERLLGKFDRVRAFKWTIVAFVILSALIFFIPPSNVWLI 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 329 MTGVCLYSITLGMGFVSMWSMIADTVEYAEWHHGVRTEGAIYGFFNFITKIAMAIGGGCAGWMLDYYHYDAGNI--TASA 406
Cdd:PRK09669 323 FALNILFNFIQNLTTPLQWSMFSDVVDYEEKRSGRRLDGLVFSTNLFAIKLGLAIGGAVVGWILAWVDYVGGAAvqSASV 402
|
410 420 430
....*....|....*....|....*....|....*...
gi 490241292 407 INGINVLMTLFPGAMFALSALFVACYSLDEKTYRDIVQ 444
Cdd:PRK09669 403 LTTINLLFTVIPGVLFAGMAIILNFYKLNDARVEAIAQ 440
|
|
| PRK09848 |
PRK09848 |
glucuronide transporter; Provisional |
20-453 |
1.54e-79 |
|
glucuronide transporter; Provisional
Pssm-ID: 182109 [Multi-domain] Cd Length: 448 Bit Score: 253.55 E-value: 1.54e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 20 IGYGFGDFASNLSFGFVSLFLLFFYTNIYGISAVQASLIFVIARVVDAAFNIVIGFAIDKTHSRYGKLRPWLLYGSIPLG 99
Cdd:PRK09848 11 VGYSLGDVANNFAFAMGALFLLSYYTDVAGVGAAAAGTMLLLVRVFDAFADVFAGRVVDSVNTRWGKFRPFLLFGTAPLM 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 100 FLTVLCF-VP--FGGEAKFYFALISYTIYCLAYTAVNTPYSALTNRLTQHEASRSSLSVYRFVLAIVGYLIVSTTADRLI 176
Cdd:PRK09848 91 IFSVLVFwVPtdWSHSSKVVYAYLTYMGLGLCYSLVNIPYGSLATAMTQQPQSRARLGAARGIAASLTFVCLAFLIGPSI 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 177 SPFSDKQLG--YVFAVSCFALLATFLFLACFGMTKERVgeeEEQTPAPTLREMLKAVAGNAPLINLSMFTVFFYIAYTVW 254
Cdd:PRK09848 171 KNSSPEEMVsvYHFWTIVLAIAGMVLYFICFKSTRENV---VRIVAQPSLKISLQTLKRNRPLFMLCIGALCVLISTFAV 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 255 MAIAIYFIKYIIGSEGFTSTFFMIQSaayIVGTVISEKI----IALIGKKKMTLVALLIGVVGVLMQYFIAGDNIWLIMT 330
Cdd:PRK09848 248 SASSLFYVRYVLNDTGLFTVLVLVQN---LVGTVASAPLvpgmVARIGKKNTFLIGALLGTCGYLLFFWVSVWSLPVALV 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 331 GVCLYSITLGMGFVSMWSMIADTVEYAEWHHGVRTEGAIYGFFNFITKIAMAIGGGCAGWMLDYYHYDAGNI-TASAING 409
Cdd:PRK09848 325 ALAIASIGQGVTMTVMWALEADTVEYGEYLTGVRIEGLTYSLFSFTRKCGQAIGGSIPAFILGLSGYIANQVqTPEVIMG 404
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 490241292 410 INVLMTLFPGAMFALSALFVACYSLDEKTYRDIVQKISLRKQNA 453
Cdd:PRK09848 405 IRTSIALVPCGFMLLAFVIIWFYPLTDKKFKEIVVEIDNRKKVQ 448
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
21-436 |
5.89e-71 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 230.66 E-value: 5.89e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 21 GYGFGDFASNLSFGFVSLFLLFFYTNIYGISAVQASLIFVIARVVDAAFNIVIGFAIDKTHSRYGKLRPWLLYGSIPLGF 100
Cdd:pfam13347 1 GYGSGALAAGIKYAGLATYLLYFYTDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRWGRRRPWLLLSAIILAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 101 LTVLCFVP--FGGEAKFYFALISYTIYCLAYTAVNTPYSALTNRLTQHEASRSSLSVYRFVLAIVGYLIVSTTADRLISP 178
Cdd:pfam13347 81 SFILLFTPpeLGRAPLFIWLLATYILLRIAYTFFEIPYWSLGPELTRDYDERTSLTSYRSFFSVGGGLLAAALAFPLVLI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 179 FSDKQL---GYVFAVSCFALLATFLFLACFGMTKERV----GEEEEQTPAPTLREMLKAVAGNAPLINLSMFTVFFYIAY 251
Cdd:pfam13347 161 LGGTGLerkGYRIFALIGAVLMLLGVIITAAGTKERVsmrsKEDTGQKEAGSLLDMLKEVFRNRAFLILLASFLLAALAM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 252 TVWMAIAIYFIKYIIGSEGFTSTFFMIQSAAYIVGTVISEKIIALIGKKKMTLVALLIGVVGVLMQYFIAGDNIWLIMTG 331
Cdd:pfam13347 241 GVLNGLLLYYFRYVLGNGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIAGFALALLLGPNNTLLFLVL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 332 VCLYSITLGMGFVSMWSMIADTVEYAEWHHGVRTEGAIYGFFNFITKIAMAIGGGCAGWMLDYYHYDAGN--ITASAING 409
Cdd:pfam13347 321 YIIIGFGYGSSFFLPWSMLADVVDYGELRTGKRREGTFFAMWSFISKLATGVGLGVSGLLLSAFGYNAGDsvQSPQAVTA 400
|
410 420
....*....|....*....|....*..
gi 490241292 410 INVLMTLFPGAMFALSALFVACYSLDE 436
Cdd:pfam13347 401 IRLLYAVLPAVLFLVALLLLYFYPLDR 427
|
|
| PRK11462 |
PRK11462 |
putative transporter; Provisional |
13-432 |
2.37e-60 |
|
putative transporter; Provisional
Pssm-ID: 183145 Cd Length: 460 Bit Score: 204.02 E-value: 2.37e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 13 VIGVKEKIGYGFGDFASNLSFGFVSLFLLFFYTNIYGISAVQASLIFVIARVVDAAFNIVIGFAIDKTHSRYGKLRPWLL 92
Cdd:PRK11462 5 VLSVKEKIGYGMGDAASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLVARALDAISDPCMGLLADRTRSRWGKFRPWVL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 93 YGSIPLGFLTVLCFVP--FGGEAKFYFALISYTIYCLAYTAVNTPYSALTNRLTQHEASRSSLSVYRFVLAIVGYLIVST 170
Cdd:PRK11462 85 FGALPFGIVCVLAYSTpdLSMNGKMIYAAITYTLLTLLYTVVNIPYCALGGVITNDPTQRISLQSWRFVLATAGGMLSTV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 171 TADRLISPF--SDKQLGYVFAVSCFALLATFLFLACFGMTKERVgeeEEQTPAPTLREMLKAVAGNAPLINLSMFTVFFY 248
Cdd:PRK11462 165 LMMPLVNLIggDNKPLGFQGGIAVLSVVAFMMLAFCFFTTKERV---EAPPTTTSMREDLRDIWQNDQWRIVGLLTIFNI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 249 IAYTVWMAIAIYFIKYIIGSEGFTSTFFMIQSAAYIVGTVISEKIIALigKKKMTL---VALLIGVVGVLMqYFIAGDNI 325
Cdd:PRK11462 242 LAVCVRGGAMMYYVTWILGTPEVFVAFLTTYCVGNLIGSALAKPLTDW--KCKVTIfwwTNALLAVISLAM-FFVPMQAS 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 326 wlIMTGVCLYSITLGMGFVS--MWSMIADTVEYAEWHHGVRTEGAIYGFFNFITKIAMAIGGGCAGWMLDYYHYDAGNIT 403
Cdd:PRK11462 319 --ITMFVFIFVIGVLHQLVTpiQWVMMSDTVDYGEWCNGKRLTGISFAGTLFVLKLGLAFGGALIGWMLAYGGYDAAEKA 396
|
410 420 430
....*....|....*....|....*....|.
gi 490241292 404 --ASAINGINVLMTLFPGAMFALSALFVACY 432
Cdd:PRK11462 397 qnSATISIIIALFTIVPAICYLLSAIIAKRY 427
|
|
| PRK10429 |
PRK10429 |
melibiose:sodium transporter MelB; |
14-442 |
3.07e-46 |
|
melibiose:sodium transporter MelB;
Pssm-ID: 182453 Cd Length: 473 Bit Score: 166.42 E-value: 3.07e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 14 IGVKEKIGYGFGDFASNLSFGFVSLFLLFFYTNIYGISAVQASLIFVIARVVDAAFNIVIGFAIDKTHSRYGKLRPWLLY 93
Cdd:PRK10429 3 ISMTTKLSYGFGAFGKDFAIGIVYMYLMYYYTDVVGLSVGLVGTLFLVARIWDAINDPIMGWIVNNTRSRWGKFKPWILI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 94 GSIPLGFLTVLCFVPFG--GEAKFYFALISYTIYCLAYTAVNTPYSALTNRLTQHEASRSSLSVYRFVLAIVGYLIVSTT 171
Cdd:PRK10429 83 GTLANSVVLFLLFSAHLfeGTAQYVFVCVTYILWGMTYTIMDIPFWSLVPTLTLDKREREQLVPYPRFFASLAGFVTAGF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 172 ADRLISPF--SDKQLGY-VFAVSCFALLATFLFLACFGMTKERVGEEEEQTPAP--TLREMLKAVAGNAPLINLSMFTVF 246
Cdd:PRK10429 163 TLPFVNYVggGDRGFGFqMFTLVLIAFFIVSTIITLRNVHEVYSSDNQVSAEGShlTLKDIVALIYKNDQLSCLLGMALA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 247 FYIAYTVWMAIAIYFIKYIIGSEGFTSTFFMIQSAAYIVGTVISEKIIALIGKKKMTLVA---LLIGVVGVLMQYFIAGD 323
Cdd:PRK10429 243 YNIASNIINGFAIYYFTYVIGDADLFPYYLSYAGAANLVTLILFPRLVKSLSRRILWAGAsifPVLSCGVLLLMGLAAPH 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 324 NIWLIMTGVCLYSITLGMGFVSMWSMIADTVEYAEWHHGVRTEGAIYGFFNFITKIAMAIGGGCAGWMLDYYHYDAGNI- 402
Cdd:PRK10429 323 NALLIVIAGILLNIGTALFWVLQVIMVADTVDYGEYKLGIRCESIAYSVQTMVVKGGSAFAAFFIGVVLGLIGYVPNVEq 402
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 490241292 403 TASAINGINVLMTLFPGAMFALSA-LFVACYSLDEKTYRDI 442
Cdd:PRK10429 403 SAQTLLGMQFIMIGLPTLFFMITLvLYFRYYRLNGDFLRRI 443
|
|
| MFS_MFSD2 |
cd17392 |
Major facilitator superfamily domain-containing protein 2 subfamily; The major facilitator ... |
19-436 |
2.71e-19 |
|
Major facilitator superfamily domain-containing protein 2 subfamily; The major facilitator superfamily domain-containing protein 2 (MFSD2) subfamily is composed of two vertebrate members, MFSD2A amd MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD2 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340950 Cd Length: 446 Bit Score: 89.84 E-value: 2.71e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 19 KIGYGFGDFASNLSFGFVSLFLLFFYTNIYGISAVQASLIFVIARVVDAAFNIVIGFAIDKTH-SRYGKLRPWLLyGSIP 97
Cdd:cd17392 1 KLCYAIGGAPYQMTSSATGFFLQIFLLDVAQMGAFSVSLILFVGRVWDAVTDPLVGYFISRSQrTGIGRLMPWIV-FSTP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 98 LGFLT--VLCFVPFGGEAKFYFALISYTIYCLAYTAVNTPYSALTNRLTQHEASRSSLSVYRFVLAIVGYLIVSTTADRL 175
Cdd:cd17392 80 LIILAyfFLWFLPPFTSLSGLWYLTFYCLFETFMTCFHVPYSALTMFLGGCQRERDSATAYRMTVEVFGTLMGATIQGQI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 176 ISPFSDKQ--------------------------LGYVFAVSCFALLATFLFLAcfgmTKERVGEEEEQ--TPAPTLREM 227
Cdd:cd17392 160 VGVAHRPRrqdctatpgtsdhpvtvlpntrraylIAALVVVVLYFVCCSILFLG----VKEQPDPLSPAsgPGLSYLAGL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 228 lKAVAGNAPLINLSMFTVFFYIAYTVWMAIAIYFIKYIIGSEGFTSTFFMIQSAAYIVGTVISEKIIALIGKKKMTLVAL 307
Cdd:cd17392 236 -KLVTGHPPYLKLVIGFLFSSLAFQMEQGNFVLFCTHAAGLGDHFQHLVLAILVSATLSIPLWQWVLQRRGKKTTSFIGI 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 308 LIgVVGVLMQYFIAGDNIWLIMTGVCLYSITLGMGFVSMWSMIADTV-EYAEWH-HGVRTEGAIYGFFNFITKIAMAIGG 385
Cdd:cd17392 315 SA-MVPFLILLALVPSNLPVAYVVAVVSGVSLAALFLLPWSMLPDVVdDFQLKNpHCPGLEPIFYSCYVFFTKLGGGLSL 393
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 490241292 386 GCAGWMLDYYHYDAGNITAS--AINGINVLMTLFPGAMFALSALFVACYSLDE 436
Cdd:cd17392 394 GISTLSLHFSGYKAGACKQPeeVVVTLKVLIAPVPICLILAGLVLFYVYPINE 446
|
|
| MFS_MFSD2B |
cd17452 |
Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily ... |
19-436 |
3.63e-16 |
|
Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily domain-containing protein 2B (MFSD2B) is closely related to MFSD2A, and their conserved genomic structure suggests that they are derived from the duplication of an ancestral gene. Variations of chromosome 2 gene expressions among patients with lung cancer or non-cancer identified MFSD2B as a potential risk or protect factor in the prognosis of lung adenocarcinoma. MFSD2B belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341010 Cd Length: 416 Bit Score: 80.25 E-value: 3.63e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 19 KIGYGFGDFASNLSFGFVSLFLLFFYTNIYGISAVQASLIFVIARVVDAAFNIVIGFAIDKTH-SRYGKLRPWLLyGSIP 97
Cdd:cd17452 1 KLCYAIGGAPNQVAGSATAFFLQIYLLDIAQITPFQASLVLFVGKAWGAATDPVVGFFISKSKwTKIGRLMPWML-GCTP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 98 LGFLT--VLCFVPFGGEAKFYFALISYTIYCLAYTAVNTPYSALTNRLTQHEASRSSLSVYRFVLAIVGYLIVSTTADRL 175
Cdd:cd17452 80 FIVVSyfFLWFVPPFTTGRFLWYLTFYCLFQALATCFHVPYSALTMFLSTDQRERDSATAYRMTVEVLGTLVGAAVQGQI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 176 ISPfsdkqlGYVFA---VSCFALLATFLFlaCFGMTKERVGEEEEQTPAPTLREMLKAVAGNAPLINLSMFTVFFYIAYT 252
Cdd:cd17452 160 VAS------AYMIAagvIGGLYLLCISVL--FLGVKERDDPYAPKSGKAIPFFKGLSLTMRHGPYLKLTASFLFISAAVQ 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 253 VWMAIAIYFIKYIIGSEGFTSTFFMIQSAAYIVGTVISEKIIALIGKKK--------MTLVALLIGVVGVLMQYFIAgdn 324
Cdd:cd17452 232 LEQSNFVLFCTHAVDLHDHFQNLVLTILVSAVVSIPFWQWFLQRFGKKAaacgiswmIPFAIMLVTIPNLIVAYVVA--- 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 325 iwlIMTGVclysiTLGMGFVSMWSMIADTVE--YAEWHHGVRTEGAIYGFFNFITKIAMAIGGGCAGWMLDYYHYDAG-- 400
Cdd:cd17452 309 ---FVSGL-----SIAASLLLPWSMLPDVVDdfRLQNPHGKGLETIFYSSYVFFTKLSAGIALGISTLSLEFAGYETGac 380
|
410 420 430
....*....|....*....|....*....|....*.
gi 490241292 401 NITASAINGINVLMTLFPGAMFALSALFVACYSLDE 436
Cdd:cd17452 381 KQPESVVLTLKLLIGAAPTCMILIGLCILMFYPITE 416
|
|
| MFS_NLS1_MFSD2A |
cd17451 |
Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of ... |
19-436 |
4.63e-15 |
|
Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of transporters; Sodium-dependent lysophosphatidylcholine (LPC) symporter 1 (NLS1) is also called major facilitator superfamily domain-containing protein 2A (MFSD2A). NLS1/MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. It also transports the essential omega-3 fatty acid docosahexaenoic acid (DHA), which is essential for normal brain growth and cognitive function, in the form of LPC into the brain across the blood-brain barrier. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. NLS1/MFSD2A belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341009 Cd Length: 419 Bit Score: 76.78 E-value: 4.63e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 19 KIGYGFGDFASNLSFGFVSLFLLFFYTNIYGISAVQASLIFVIARVVDAAFNIVIGFAIDKTH-SRYGKLRPWLLYgSIP 97
Cdd:cd17451 1 KLCYAIGGAPYQITGCALGFFLQIYLLDVAQLDPFYASIILFVGRAWDAITDPTVGFFVSKSPwTRFGRLMPWIIF-STP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 98 LGFLT--VLCFVPFGGEAKFYFALISYTIYCLAYTAVNTPYSALTNRLTQHEASRSSLSVYRFVLAIVGYLIVSTTADRL 175
Cdd:cd17451 80 FAVLSyfLIWFVPDFSQGKVMWYLLFYCLFQTLQTCFHVPYSALTMFISTEQKERDSATAYRMTVEVLGTVLGTAIQGQI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 176 ISpfsdkQLGYVFAVSCFALLATFLFLACFGMTKERVGEEEEQTPAP-TLREMLKAVAGNAPLINLSMFTVFFYIAYTVW 254
Cdd:cd17451 160 VG-----MAAYMIAAGVICAIYVLCAIILFLGVREQREPCELKSQKPvSFFKGLKLVMSHGPYIKLITGFLFTSLAFMLL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 255 MAIAIYFIKYIIG-SEGFTSTFFMIQSAAyIVGTVISEKIIALIGKKKMTLVAlLIGVVGVLMQYFIAGDNIWLIMTGVC 333
Cdd:cd17451 235 EGNFALFCTYTLGfRNDFQNILLVIMLSA-TLTIPFWQWFLTRFGKKTAVYIG-ISSAVPFLILVVLVESNLIVTYVVSV 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 334 LYSITLGMGFVSMWSMIADTVE--YAEWHHGVRTEGAIYGFFNFITKIAMAIGGGCAGWMLDYYHYDAGNITAS-AIN-G 409
Cdd:cd17451 313 AAGVSVAAAFLLPWSMLPDVVDdfKLKNPDSQGHEAIFYSFYVFFTKFASGVSLGISTLSLDFAGYQTRGCSQPeEVNlT 392
|
410 420
....*....|....*....|....*..
gi 490241292 410 INVLMTLFPGAMFALSALFVACYSLDE 436
Cdd:cd17451 393 LKMLVSAAPVVLILLGLLLFKLYPIDE 419
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
27-417 |
1.56e-14 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 74.92 E-value: 1.56e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 27 FASNLSFGFVSLFLLFfYTNIYGISAVQASLIFVIARVVDAAFNIVIGFAIDkthsRYGKLRPwLLYGSiplgFLTVLCF 106
Cdd:cd17325 6 FLDMLGYGIIIPILPL-YAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSD----RFGRKRL-LLLGL----LLLAVST 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 107 VPFGGEAKFYFALISYTIYCLAYTAVNTPYSALTNRLTQHEASRSSLSVYRFVLAI---VGYLIVSttadrLISPFSDKQ 183
Cdd:cd17325 76 LLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLgflIGPLLGG-----LLADALGYR 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 184 LGYVFAvSCFALLAtfLFLACFGMTKERVGEEEEQTPAPTLREMLKAVAGNAPLINLSMFTVFFYIAYT-VWMAIAIYFI 262
Cdd:cd17325 151 APFLVC-AALALLA--LVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGaLEPFLPLYAA 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 263 KYIIGSEGFTSTFFMIQSAAYIVGTVISEKIIALIGKKKMTLVALLIGVVGVLMqyFIAGDNIWLIMTGVCLYSITLGMG 342
Cdd:cd17325 228 ELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLL--LPLATSFWLLLLLLALLGLGLGLV 305
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490241292 343 FVSMWSMIADTVeyaewHHGVRteGAIYGFFNFITKIAMAIGGGCAGWMLDYYHYDAGNITASAINGINVLMTLF 417
Cdd:cd17325 306 FPATLALLADIV-----PPEGR--GTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
23-417 |
2.42e-13 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 71.50 E-value: 2.42e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 23 GFGDFASNLSF----GFVSLFLLffytnIYGISAVQASLIFVIARVVDAAFNIVIGFAIDKTHSRYGKLRPWLLYGS--- 95
Cdd:cd17313 5 GFGFFGIEFGWalenSYVPPILQ-----TLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRIGRRRPFILVGApla 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 96 ----IPLGFLTVLCFVPFGGEAKFYFALISYTIYCL--AYTAVNTPYSALTNRLTQHEASRSSLSVYRF---VLAIVGYL 166
Cdd:cd17313 80 alglILIPNAADIGLALGDGPRTWALVLFVLGIVLLdfAMNVCQGPVRALLPDLVPPEQRSKANGIINFmggLGGVLGYL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 167 IVSTTADRLISPFSD-KQLGYVFAVSCFALLATFLFLACFGMTKERVGEEEEQTPAPTLREMLKA-----VAGNAPLINL 240
Cdd:cd17313 160 LGAILWDHNWFGFALgGNLKVPFYIGAIILLVCVLVTLFFVKEPPLSPEAGEHSENPSLGEVLKSllkllKIMPRSLLRL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 241 SMFTVFFYIA-------YTVWMAIAIY------FIKYIIGsEGFTSTFFMIQSAAYIVGTVISEKIIALIGKKKMTLVAL 307
Cdd:cd17313 240 LLVIFFWWIAffpfelfFTDYMGEEVYhgtsaaSSHYGAG-VRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 308 LIGVVGVLMQYFIagDNIWLIMTGVCLYSITLGMGFVSMWSMIADTVEYAEWHHGVRTegaiyGFFNFITKIAMAIGGGC 387
Cdd:cd17313 319 VLFAVGMALMALV--HNVTVALVLFALGGIGWATININPYPLVSDYHSESGRGQGTDT-----GLLNLAISLAQILVSLL 391
|
410 420 430
....*....|....*....|....*....|
gi 490241292 388 AGWMLDYYHYDAGNITASAINGINVLMTLF 417
Cdd:cd17313 392 AGPIIDVKGYGTVFPVAAVASFLSLVGALF 421
|
|
| MFS_MFSD12 |
cd17491 |
Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily ... |
19-380 |
8.59e-13 |
|
Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily domain-containing protein 12 (MFSD12) protein subfamily includes a group of uncharacterized proteins similar to human MFSD2. MFSD2 is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD12 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341044 Cd Length: 438 Bit Score: 69.98 E-value: 8.59e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 19 KIGYGFGDFASNLSFGFVSLFLLFFYTNIYGISAVQASLIFVIARVVDAAFNIVIGFAIDKT--HSRYGKLRPWLLYGSI 96
Cdd:cd17491 1 RIAYGVGHVLNDLCASMWFTYLLVYFHLVLGFSSALAGILLLIGQVADAISTPLVGYESDRTngCGKYGRRKSWHLIGTI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 97 PLGFLTVLCFVP---FGGE----AKFYFALISYTIYCLAYTAVNTPYSALTNRLTQHEASRSSLSVYRFVLAIVGYLIVS 169
Cdd:cd17491 81 CVLLSFPFIFNPclgCSDStsewAKLVYYGPFIIIFQFGWAAVQISHLSLIPELTSDEHERVELTALRYAFTVIANITVY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 170 TTADRLISPFSDKQLG------------YVFAVSCFALLATFLFLaCFGMTKERVGEEEEQTPAPTLREMLKAVAGNAPL 237
Cdd:cd17491 161 LIAWLLLQQSSGDSVNptsaqdlpifrnLSLIVVGIGFLFSLLFH-LGTKEPRPPTDLSTTTNEGEEVTAPEEPRLTWKE 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 238 --------------------INLSMFTVFFYIAYTVWM---AIAIyfIKYIIGSEGFTSTFFMiqsaayivgtvisEKII 294
Cdd:cd17491 240 wlrepqfyqvallymctrliVNLSQVYIPLYLTETLQLpkeSIAI--VPLVMYVSGFLTSLVM-------------KPIN 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 295 ALIGKKKMTLVALLIGVVGVLMQYFIAGDNiwlimTGVCLY--SITLGMG----FVSMWSMIADTVEyaewhHGVRTEGA 368
Cdd:cd17491 305 KKIGRKITYLLGLLFVLGFCIWVWFQSGSS-----RTYEIYgaAVLLGVGsatlLVTSLSMTADLIG-----TNTESGAF 374
|
410
....*....|..
gi 490241292 369 IYGFFNFITKIA 380
Cdd:cd17491 375 VYGAMSFTDKLS 386
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
24-396 |
4.22e-11 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 64.37 E-value: 4.22e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 24 FGDFASNLSFGFVSLFLLFFYTNIYGISAVQASLIFVIARVVDAAFNIVIGFAIDkthsRYGKlRPWLLYGSIPLGFLTV 103
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLAD----RFGR-RPVLLLGLLLFALGAL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 104 LcfvpFGGEAKFYFALISYTIYCLAYTAVNTPYSALTNRLTqHEASRSSLSVYRFVLAIVGYLIVSTTADRLISPFSDKQ 183
Cdd:cd06174 77 L----FAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLF-PERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGW 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 184 LGYVFAVSCFALLATFLFLACFGMTKERVGEEEEQTPAPTLREMLKAVAGNAPLINLSMFTVFFYIAYTVWMAIAIYFIK 263
Cdd:cd06174 152 RAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 264 YIIGSEGFTSTFFM-IQSAAYIVGTVISEKIIALIGKKKMTLVALLIGVVGVLMqYFIAGDNIWLIMTGVCLYSITLGMG 342
Cdd:cd06174 232 DLGGLSVAVAGLLLsLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLA-LLLLAPSLLLLLLLLLLLGFGLGGL 310
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 490241292 343 FVSMWSMIADTVEyaewhhgVRTEGAIYGFFNFITKIAMAIGGGCAGWMLDYYH 396
Cdd:cd06174 311 LPLSFALIAELFP-------PEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATF 357
|
|
| MFS_BCD_PucC-like |
cd06176 |
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator ... |
73-393 |
2.78e-10 |
|
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator Superfamily; The bacteriochlorophyll delivery (BCD) family, also called PucC family, is composed of the PucC protein and related proteins including LhaA (also called ORF477 and F1696) and bacteriochlorophyll synthase 44.5 kDa chain (also called ORF428). These proteins are found in photosynthetic organisms. Rhodobacter capsulatus LhaA and PucC are implicated in light-harvesting complex 1 and 2 (LH1 and LH2) assembly. PucC may function to shepherd or sequester LH2 alpha and beta proteins to facilitate proper assembly, as well as deliver bacteriochlorophyll a to nascent LH2 complexes. The BCD family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 349950 [Multi-domain] Cd Length: 409 Bit Score: 61.75 E-value: 2.78e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 73 IGFAIDKTHSRYGKLRPWLLYGSipLGFLTVLCFVPFG----GEAKFYFALI----SYTIYCLAYTAVNTPYSALTNRLT 144
Cdd:cd06176 55 IGHRSDTHPLRGYRRTPYIWLGM--LLLALGLALAPFAalllAGAAFWLGLAlavlAFLLYGIGVGAAGTAFLALLADLT 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 145 qHEASRSSLSVYRFVLAIVGYLIVSTTADRLISPFSDKQLGYVFAVSCFALLaTFLFLACFGMTK--ERVGEEEEQTPAP 222
Cdd:cd06176 133 -PEERRPRAVTVVWTMLILGIIVTAIVFGRLLDPYSPERLIQVFQIVALVAL-LLALLALWGVERrrSRAALAAEEAPPE 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 223 TLREMLKAVAGNAPLINlsmFTVFfyiaytVWMAIAIYFIKYII----GSEGF------TSTFFMIQSAAYIVGTVISEK 292
Cdd:cd06176 211 TFREALRLLWASPQARR---FFIF------LFLSTLALFMQDVIlepfGGEVFgmsvgeTTRLTAIWGGGTLLGMLLAGF 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 293 IIALIGKKKMT----LVALLIGVVGVLMQYFIAgdNIWLIMTGVCLYSITLGMGFVSMWSMIADTVeyAEWHHGVRTega 368
Cdd:cd06176 282 LLSRRLGKKRTaalgCLLSALGFLLLALAGLLG--NPWLFRPGVFLLGLGNGLFTVGALTLMMDLT--GEGTAGLFM--- 354
|
330 340
....*....|....*....|....*
gi 490241292 369 iyGFFNFITKIAMAIGGGCAGWMLD 393
Cdd:cd06176 355 --GLWGAAQALARGLGTLLGGALRD 377
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
237-417 |
3.00e-09 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 58.34 E-value: 3.00e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 237 LINLSMFTVFFYIAYTVWMAIAIYFIKYIIGSEGFT----STFFMIQSAAYIVGTVISEKIIALIGKKKMTLVALLIGVV 312
Cdd:COG2271 179 LLRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSlaqaGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLA 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 313 GVLMQYFIAGDNIWLIMTGVCLYSITLGMGFVSMWSMIADTVeyaewhhGVRTEGAIYGFFNFITKIAMAIGGGCAGWML 392
Cdd:COG2271 259 ALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELF-------PKKARGTASGLVNTFGFLGGALGPLLVGYLL 331
|
170 180
....*....|....*....|....*
gi 490241292 393 DYYHYDAGNITASAINGINVLMTLF 417
Cdd:COG2271 332 DATGYQAAFLLLAALALLAALLALL 356
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
24-395 |
2.66e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 52.61 E-value: 2.66e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 24 FGDFASNLSFGFVSLFLLFFYTNIYGISAVQASLIFVIARVVDAAFNIVIGFAIDkthsRYGKlRPWLLYGSIPLGFLTV 103
Cdd:cd17329 6 IGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLAD----RFGR-KPVMLAGLLLRALGFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 104 LCFVPFGgeakFYFALISYTIYCLAYTAVNTPYSALTNRLTQHEASRSSLSVYRFVL---AIVGYLIVSTTADRLISpfs 180
Cdd:cd17329 81 LLGFAHS----PWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAInlgVAIGPLLGGLLLLYSFR--- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 181 dkqlgYVFAVscfALLATFLFLACFGMTKERVGEEEEQTPAPTLREMLKAVAGNAPLINLSMFTVFFYIAYTVWM-AIAI 259
Cdd:cd17329 154 -----LLFLA---AAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLEsTLPV 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 260 YFIKYIIGSEGFTSTFFMIQSAAYIVGTVISEKIIALIGKKKMTLVALLIGVVGVLMQYFIAgdNIWLIMTGVCLYSITL 339
Cdd:cd17329 226 YVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFAN--TLAVLILAMIVLTLGE 303
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 490241292 340 GMGFVSMWSMIADTVEyaewhhgVRTEGAIYGFFNFITKIAMAIGGGCAGWMLDYY 395
Cdd:cd17329 304 MLVFPAVQTLVAALAP-------PDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLL 352
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
27-383 |
5.61e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 51.51 E-value: 5.61e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 27 FASNLSFGFVsLFLLFFYTNIYGISAVQASLIFVIARVVDAAFNIVIGFAIDkthsRYGKlRPWLLYGSIPLGFLTVLCF 106
Cdd:COG2814 20 FLSGLGIGIV-LPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLAD----RFGR-RRVLLLGLLLFALGSLLCA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 107 VPFGgeakFYFALISYTIYCLAYTAVNTPYSALTNRLTQHEASRSSLSVYRFVLAIvGYLIVSTTADRLISPFSdkqLGY 186
Cdd:COG2814 94 LAPS----LWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGL-GPALGPLLGGLLADLFG---WRW 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 187 VFAVSCFALLATFLFLAcfgmtkeRVGEEEEQTPAPTLREMLKAVAGNAPLINLSMFTVFFYIAYTVWMAIAIYFIKYII 266
Cdd:COG2814 166 VFLVNAVLALLALLLLL-------RLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 267 G-SEGFTSTFFMIQSAAYIVGTVISEKIIALIGKKKMTLVALLIGVVGVLMqyFIAGDNIWLIMTGVCLYSITLGMGFVS 345
Cdd:COG2814 239 GlSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLL--LALAGSLWLLLLALFLLGFGFGLLFPL 316
|
330 340 350
....*....|....*....|....*....|....*...
gi 490241292 346 MWSMIADTVeyaewhhGVRTEGAIYGFFNFITKIAMAI 383
Cdd:COG2814 317 LQALVAELA-------PPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
27-384 |
7.71e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 50.88 E-value: 7.71e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 27 FASNLSFGFVSLFLLFFYTNIYGISAVQASLIFVIARVVDAAFNIVIGFAIDkthsRYGKlRPWLLYGSIPLGFLTVLCF 106
Cdd:pfam07690 6 FLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSD----RFGR-RRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 107 VPfggeAKFYFALISYTIYCLAYTAVNTPYSALTNRLTQHEAsRSSLSVYRFVLAIVGYLIVSTTADRLISPFSdkqLGY 186
Cdd:pfam07690 81 FA----SSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEE-RGRALGLVSAGFGLGAALGPLLGGLLASLFG---WRA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 187 VFAVSCFALLATFLFLACFGMTKERVGEEEEQTPAPTLREMLKAVAGNAPLINLSMFTVFFYIAYTVWMAIAIYFIKYII 266
Cdd:pfam07690 153 AFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 267 gSEGFTSTFFMIQSAAYIVGTVISEKIIALIGKKKMTLVALLIGVVGVLMQYFIAG-DNIWLIMTGVCLYSITLGMGFVS 345
Cdd:pfam07690 233 -SALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLtLSSLWLLLALLLLGFGFGLVFPA 311
|
330 340 350
....*....|....*....|....*....|....*....
gi 490241292 346 MWSMIADTVeyaewhhGVRTEGAIYGFFNFITKIAMAIG 384
Cdd:pfam07690 312 LNALVSDLA-------PKEERGTASGLYNTAGSLGGALG 343
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
163-417 |
2.04e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 46.41 E-value: 2.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 163 VGYLIVSTTADRLISPFSdkqLGYVFAVSCFALLATFLFLACFGMTKERVGEEEEQTPAPTLREMLKavagnapLINLSM 242
Cdd:COG2223 140 LGAAVAAFLAPLLIAAFG---WRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEALR-------DPRFWL 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 243 FTVFFYIAYTVWMAIAIYFIKYIIGSEG--------FTSTFFMIQSAAYIVGTVISEKIialiGKKKMTLVALLIGVVGV 314
Cdd:COG2223 210 LSLLYFGTFGSFIGFSSWLPPYLVDQFGlsaataglLAALFALLGALGRPLGGWLSDRI----GGRRVLLIVFALMALGL 285
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 315 LMQYFIAGdNIWLIMTGVCLYSITLGMGFVSMWSMIADTVeyaewhhGVRTEGAIYGFFNFITKIAMAIGGGCAGWMLDY 394
Cdd:COG2223 286 LLLALALG-SLWLFLVLFLLLGLALGGGNGAVFALVPDIF-------PTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDA 357
|
250 260
....*....|....*....|....
gi 490241292 395 YH-YDAGNITASAINGINVLMTLF 417
Cdd:COG2223 358 TGsYTAAFLVFAVLALVALVLTLL 381
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
161-414 |
2.75e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 46.00 E-value: 2.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 161 AIVGYLIVSttadrLISPFSDKQLGYVFAVSCFALLATFLFLACFGMTKERVGEEEEQTPAPTLREM---LKAVAGNAPL 237
Cdd:cd17370 137 AVLGPLLAA-----LLLYLLGGNYRTIFLLAAIPALLALLILLFVVKEYPRPPKLRKKSKKTSLKKLpkaFWLYLLAVAL 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 238 INLSMFTVFFYI--AYTVWMAIAIYFIKYIIgsegftstfFMIQSA--AYIVGtVISEKIialiGKKKMTLVALLIGVVG 313
Cdd:cd17370 212 FALGNFSFAFLIlrAQELGLSAALIPLLYAL---------FNLVYAlaAYPAG-RLSDRI----GRKKLLILGYLSLALA 277
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 314 VLmqYFIAGDNIWLIMTGVCLYSITLGMGFVSMWSMIADTVEyaewhhgVRTEGAIYGFFNFITKIAMAIGGGCAGWMLD 393
Cdd:cd17370 278 YL--GFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVP-------AELRGTAYGLFNTVVGIGWLLASLIAGYLWD 348
|
250 260
....*....|....*....|.
gi 490241292 394 YYHYDAGNITASAINGINVLM 414
Cdd:cd17370 349 LISPSAAFLFSAVLALIALLL 369
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
46-354 |
3.60e-05 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 45.62 E-value: 3.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 46 NIYGISAVQASLIFVIARVVDAAFNIVIGFAIDKTHSRYGklrpwLLYGSIplgfLTVLCFVPFGGEAKFYFALISYTIY 125
Cdd:COG0738 36 DAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRG-----LLLGLL----LMALGLLLFALAPSYPLLLLALFLL 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 126 CLAYTAVNTPYSALTNRLtQHEASRSSLSVYRF---VLAIVGYLIVSTtadrLISPFSDKQLGYVFAVSCFALLATFLFL 202
Cdd:COG0738 107 GLGLGLLDVAANPYVAAL-GPETAASRLNLLHAffsLGALLGPLLGGL----LILLGLSLSWHLPYLILAVLLLLLALLF 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 203 ACFGMTKERVGEEEEQTPAPTLREMLKAvagnaPLINLSMFTVFFYIA--YTVWMAIAIYFIKYIIGSEGFTSTFFMIQS 280
Cdd:COG0738 182 LRSKLPEIEEEEEEAAGSAASLKSLLKN-----PRLLLGGLAIFLYVGaeGAIGDWLPLYLKDVLGLSEATAALGLSLFW 256
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490241292 281 AAYIVGTVISEKIIALIGKKKMTLVALLIGVVGVLMqyFIAGDNIWLIMTGVCLYSITLGMGFVSMWSMIADTV 354
Cdd:COG0738 257 GGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLL--ALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGL 328
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
24-417 |
3.82e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 45.68 E-value: 3.82e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 24 FGDFASNLSFGFVSLFLLFFYTNIYGiSAVQASLIFVIARVVDAAFNIVIGFAIDkthsRYGKlRPWLLYGSIPLGFLT- 102
Cdd:cd06173 6 LAQLLSALGDWIFTVALPWLVLQLTG-SALLVGLVLAAFFLPFLLFSPFAGVLAD----RFDR-RRLLILADLLRALLAa 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 103 VLCFVPFGGEAKFYFALISYTIYCLAYTAVNTPYSALTNRLTQHEASRSSLSVYRFVLAIvGYLIVSTTADRLISPFSdk 182
Cdd:cd06173 80 VLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQL-ARIIGPALGGLLVALLG-- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 183 qLGYVFAVSCFALLATFLFLACFGMTKERVGEEEEQTPAPTLREMLKAVAGNAPLINLSMFTVFFYIAYTVWMAIAIYFI 262
Cdd:cd06173 157 -PGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 263 KYIIG-SEGFTSTFFMIQSAAYIVGTVISEKIIALIGKKKMTLVALLIGVVGVLMQYFIAgdNIWLIMTGVCLYSITLGM 341
Cdd:cd06173 236 KEVLGgGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSP--SLWLLLAALFLLGLAGGL 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490241292 342 GFVSMWSMIADTVEyaEWHHgvrteGAIYGFFNFITKIAMAIGGGCAGWMLDYYHYDAGNITASAINGINVLMTLF 417
Cdd:cd06173 314 FNVPLNTLLQLRVP--DELR-----GRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
234-392 |
1.94e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 43.30 E-value: 1.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 234 NAPLINLSMFTVFFYIAYTVWM-AIAIYFIKYIIG-SEGFTSTFFMIQSAAYIVGTVISEKIIALIGKKKMTLVALLIGV 311
Cdd:COG0738 5 NYRRALIAIYLLFFLWGFATALwGPLIPALKDAFGlSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 312 VGVLMqyFIAGDNIWLIMTGVCLYSITLGMGFVSMWSMIADtveyaewhHGVRTEGAIYGFFNFITKIAMAIGGGCAGWM 391
Cdd:COG0738 85 LGLLL--FALAPSYPLLLLALFLLGLGLGLLDVAANPYVAA--------LGPETAASRLNLLHAFFSLGALLGPLLGGLL 154
|
.
gi 490241292 392 L 392
Cdd:COG0738 155 I 155
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
235-417 |
2.81e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 43.04 E-value: 2.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 235 APLINLSMFTVFFYIAYTVWMAIAIYFIKYIIGSEGFTSTFFMIQSAAYIVGTVISEKIIALIGKKKMTLVALLIGVVGV 314
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 315 LMQYFIagDNIWLIMTGVCLYSITLGMGFVSMWSMIADTVEYAEWhhgvrteGAIYGFFNFITKIAMAIGGGCAGWMLDY 394
Cdd:COG2814 90 LLCALA--PSLWLLLAARFLQGLGAGALFPAALALIADLVPPERR-------GRALGLLGAGLGLGPALGPLLGGLLADL 160
|
170 180
....*....|....*....|...
gi 490241292 395 YHYDAGNITASAINGINVLMTLF 417
Cdd:COG2814 161 FGWRWVFLVNAVLALLALLLLLR 183
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
220-416 |
2.87e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 42.92 E-value: 2.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 220 PAPTLREMLKAVAGNAPLINLSMFTVFFYIA-YTVWMAIAIYFIKYIIGSEGFTSTFFMIQSAAYIVGTVISEKIIALIG 298
Cdd:cd17324 183 GSLGLLSSLLLLLRNPRLRLAYLITFLLFGGfFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGG 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 299 KKKMTLVALLIGVVGVLMQYFiaGDNIWLIMTGVCLYSITLGMGFVSMWSMIADTVEyaewhhgvRTEGAIYGFFNFITK 378
Cdd:cd17324 263 RRALLIALLLLAAALLLLTLL--GPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP--------EARGLASSLYLAAYN 332
|
170 180 190
....*....|....*....|....*....|....*...
gi 490241292 379 IAMAIGGGCAGWMLDYYHYDAGNITASAINGINVLMTL 416
Cdd:cd17324 333 LGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
240-418 |
3.83e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.41 E-value: 3.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 240 LSMFTVFFYIAYTVWMAIAIYFIKYIIGSEGFTSTFFMIQSAAYIVGTVISEKIIALIGKKKMTLVALLIGVVGVLMqyF 319
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL--L 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 320 IAGDNIWLIMTGVCLYSITLGMGFVSMWSMIADTVEYAEWhhgvrteGAIYGFFNFITKIAMAIGGGCAGWMLDYYHYDA 399
Cdd:pfam07690 80 LFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEER-------GRALGLVSAGFGLGAALGPLLGGLLASLFGWRA 152
|
170
....*....|....*....
gi 490241292 400 GNITASAINGINVLMTLFP 418
Cdd:pfam07690 153 AFLILAILSLLAAVLLLLP 171
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
187-417 |
3.90e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 42.58 E-value: 3.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 187 VFAVSCFALLATFLFLACFGMTKERVGEEEEQTPAPTLREMLKAVagnaplINLSMFTVFFYIAYTVWMA-IAIYFIKYI 265
Cdd:cd17489 152 LFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKV------LPPALILFLASIAYGAISTfLPLYAAERG 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 266 IGSEGFtstFFMIQSAAYIVGTVISEKIIALIGKKKMTLVALLIGVVGVLMQYFiaGDNIWLIMTGVCLYSITLGMGFVS 345
Cdd:cd17489 226 ISNAGL---FFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSF--AGSPWMLLLAAVLYGLGFGLLFPA 300
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490241292 346 MWSMIADTVEYAEwhhgvrtEGAIYGFFNFITKIAMAIGGGCAGWMLDYYHYDAGNITASAINGINVLMTLF 417
Cdd:cd17489 301 LQALAVDLVPPHR-------RGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIF 365
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
240-352 |
2.52e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 39.89 E-value: 2.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 240 LSMFTVFFYIAYTVWMAIAIYFIKYIIG-SEGFTSTFFMIQSAAYIVGTVISEKIIALIGKKKMTLVALLIGVVGVLMQY 318
Cdd:cd17316 182 LILLWFFISFGYYGLTTFLPTYLQTVLGlSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLF 261
|
90 100 110
....*....|....*....|....*....|....
gi 490241292 319 FIAGDNIWLIMTGVCLYSITLGMGFVSMWSMIAD 352
Cdd:cd17316 262 YLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAE 295
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
33-202 |
3.20e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 39.45 E-value: 3.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 33 FGFVSLFLLFFYTNIYGISAVQASLIFVIARVVDAAFNIVIGFAIDKTHsrygklRPWLLYGSIPLGFLTVLCFVPFGGe 112
Cdd:cd17370 214 LGNFSFAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIG------RKKLLILGYLSLALAYLGFALGSS- 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 113 akFYFALISYTIYCLAYTAVNTPYSALTNRLTQHEASRSSLSVYRFVLAIvGYLIVSTTADRLISPFSdkqLGYVFAVSC 192
Cdd:cd17370 287 --LWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGI-GWLLASLIAGYLWDLIS---PSAAFLFSA 360
|
170
....*....|
gi 490241292 193 FALLATFLFL 202
Cdd:cd17370 361 VLALIALLLL 370
|
|
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
268-417 |
4.45e-03 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 39.12 E-value: 4.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 268 SEGFTSTFFMIQSAAYivgtVISEKIIALIG-KKKMTLVALLIGVVGVLMQYFIAG--------DNIWLIMTGVCLYSIT 338
Cdd:cd17385 234 SPGQVGLMFLILAGSY----AISAPLWGWLSdKKKIPKWLMVIGSIITGVGFLLLGpapllpikSELWMVIIGLVLLGLS 309
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490241292 339 LGMGFVSMWSMIADTVEYAEWHHGVRTEGAIYGFFNFITKIAMAIGGGCAGWMLDYYHYDagnITASAINGINVLMTLF 417
Cdd:cd17385 310 LGAALVPTFPELLNCAREYGFPDNLSTYGLVSGLFNAAFSLGAFIGPTLGGFLLERLGFE---WAATIQAGLAFVVGIL 385
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
20-203 |
4.84e-03 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 39.10 E-value: 4.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 20 IGYGFGDFASNLSFGFVSLFLLFFYTNIYGISAVQASLIFVIARVVDAAFNIVIGFAIDkthsRYGKlRPWLLYGSIplg 99
Cdd:cd17325 202 LALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSD----RIGR-KPLILIGLL--- 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 100 fLTVLCFVPFGGEAKFYFALISYTIYCLAYTAVNTPYSALTNRLTQHEASRSSLSVYRFVLAIvGYLIVSTTADRLISPF 179
Cdd:cd17325 274 -LSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSL-GMVLGPLLGGFLYDAF 351
|
170 180
....*....|....*....|....
gi 490241292 180 SDKQLGYVFAVSCFALLATFLFLA 203
Cdd:cd17325 352 GFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
186-407 |
7.20e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 38.32 E-value: 7.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 186 YVFAVSCFALLATFLFLAcfgMTKERVGEEEEQTPAPTLREMLKAVAGNAPLINLSMFTVFFYIAYTVWMAIAIYFIKYI 265
Cdd:cd17474 153 YPFFLLAALIPVAFLAIL---FLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLY 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490241292 266 IGSEGFTSTFFMIQSAAYIVGTVISEKIIAL-IGKKKMTLVALLIGVVGVLMqyFIAGDNIWLIMTGVCLYSITLGMGFV 344
Cdd:cd17474 230 GISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYALSLLL--LGFVPSLALLLIAIVLFGLGLGLNLP 307
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490241292 345 SMWSMIADTVEYAEwhhgvrtEGAIYGFFNFITKIAMAIGGGCAGWMLDYYHYDAGNITASAI 407
Cdd:cd17474 308 LLTTLVTELAPEEE-------RGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAI 363
|
|
| |
