View
Concise Results
Standard Results
Full Results
penicillin-binding transpeptidase domain-containing protein [Thermotoga maritima]
Protein Classification
penicillin-binding protein 2 ( domain architecture ID 1002396 )
penicillin-binding protein (PBP) 2 is a membrane-associated enzyme that is involved in the synthesis of cross-linked peptidoglycan
List of domain hits
Name
Accession
Description
Interval
E-value
pbp2_mrdA super family
cl37268 penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ...
5-540
0e+00
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
TIGR03423 :Pssm-ID: 274573 [Multi-domain]
Cd Length: 592
Bit Score: 528.63
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 5 LILI L MALS F VLIIMKA F QV Q ILEH E KHKKYIDLLQT RLV K IP A PRG K I ISSD G KV LA KDEVVYV L ------- D PWLNSI 77
Cdd:TIGR03423 5 VLGG L VLAL F GVLAARL F YL Q VIRG E EYATLSEDNRI RLV P IP P PRG L I LDRN G VL LA DNRPSFS L eivpekv D DLDATL 84
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 78 D E L K K TGLFT PE E I LSLV K G ------- E S I VI - DKARADVISK -------- A G MRVVMDYR R K Y -- EP LA P HV V GYV NA - 138
Cdd:TIGR03423 85 D R L A K LLDLD PE D I ARFL K E lkrsrrf E P I PL k SDLTEEEVAR favnqyrl P G VEIEARLK R Y Y py GE LA A HV L GYV GE i 164
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 139 ---------------- D RA G VY G V E SV Y DEF L T G TD G VKM V F V EPS G AISSEVL R S PP K PG E D VT LTID T R I Q KV AE ES L 202
Cdd:TIGR03423 165 needlerlepanyagg D YI G KS G I E KY Y EDE L R G KP G YRE V E V NAR G RVIRTLS R V PP V PG K D LV LTID A R L Q QA AE KA L 244
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 203 E ki G NP G S V ILS D V RTGEILA LA S F P EYN P QD F YE G FTKREWERFARNSPS PL I NRAI SSA Y S PGS SI K ILW A V AAL LN G 282
Cdd:TIGR03423 245 G -- G RR G A V VVM D P RTGEILA MV S T P SFD P NL F VD G ISSKDYKALLNDPDR PL L NRAI QGV Y P PGS TF K PVV A L AAL EE G 322
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 283 V - D PE EK I N C R G V F EYRN srgevv A R Y R D WK EE GHG FT DLRKAI RV SC N VYFYQL G L K LG V DK MV E V AK KLSIFE KTGID 361
Cdd:TIGR03423 323 V i T PE TR I Y C P G Y F QLGG ------ R R F R C WK RG GHG RV DLRKAI EE SC D VYFYQL A L R LG I DK IA E Y AK RFGFGQ KTGID 396
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 362 LPGEKSG TL PS P EWK MSKI G E PWYPGDT ILM SIGQGY LTA TP IE L LKLVSLV AN E G IF Y R PH V VK R I GS ------ KAVK P 435
Cdd:TIGR03423 397 LPGEKSG LV PS R EWK RKRF G Q PWYPGDT LNV SIGQGY VLV TP LQ L AVATAAL AN G G KL Y K PH L VK S I ED pdggvv RRTE P 476
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 436 E IETQVQ I DEKIWNFIKDA M V DV T sfkg N EKE dp GTA YHVFGDF PY RV AGKTGTA E ----------- A GSGA ---- P H SW 500
Cdd:TIGR03423 477 E VLRPLP I SPENLDVVREG M R DV V ---- N GPG -- GTA RRARLGL PY KM AGKTGTA Q vvslkqgekyd A EQIP erlr D H AL 550
570 580 590 600
....*....|....*....|....*....|....*....|
gi 490182649 501 FV G FAP AE NP EV A IV V M VEHGG Y GS G AA SQ IAR RVLEE Y F 540
Cdd:TIGR03423 551 FV A FAP YD NP KI A VA V I VEHGG G GS S AA AP IAR KIMDA Y L 590
Name
Accession
Description
Interval
E-value
pbp2_mrdA
TIGR03423 penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ...
5-540
0e+00
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 274573 [Multi-domain]
Cd Length: 592
Bit Score: 528.63
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 5 LILI L MALS F VLIIMKA F QV Q ILEH E KHKKYIDLLQT RLV K IP A PRG K I ISSD G KV LA KDEVVYV L ------- D PWLNSI 77
Cdd:TIGR03423 5 VLGG L VLAL F GVLAARL F YL Q VIRG E EYATLSEDNRI RLV P IP P PRG L I LDRN G VL LA DNRPSFS L eivpekv D DLDATL 84
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 78 D E L K K TGLFT PE E I LSLV K G ------- E S I VI - DKARADVISK -------- A G MRVVMDYR R K Y -- EP LA P HV V GYV NA - 138
Cdd:TIGR03423 85 D R L A K LLDLD PE D I ARFL K E lkrsrrf E P I PL k SDLTEEEVAR favnqyrl P G VEIEARLK R Y Y py GE LA A HV L GYV GE i 164
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 139 ---------------- D RA G VY G V E SV Y DEF L T G TD G VKM V F V EPS G AISSEVL R S PP K PG E D VT LTID T R I Q KV AE ES L 202
Cdd:TIGR03423 165 needlerlepanyagg D YI G KS G I E KY Y EDE L R G KP G YRE V E V NAR G RVIRTLS R V PP V PG K D LV LTID A R L Q QA AE KA L 244
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 203 E ki G NP G S V ILS D V RTGEILA LA S F P EYN P QD F YE G FTKREWERFARNSPS PL I NRAI SSA Y S PGS SI K ILW A V AAL LN G 282
Cdd:TIGR03423 245 G -- G RR G A V VVM D P RTGEILA MV S T P SFD P NL F VD G ISSKDYKALLNDPDR PL L NRAI QGV Y P PGS TF K PVV A L AAL EE G 322
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 283 V - D PE EK I N C R G V F EYRN srgevv A R Y R D WK EE GHG FT DLRKAI RV SC N VYFYQL G L K LG V DK MV E V AK KLSIFE KTGID 361
Cdd:TIGR03423 323 V i T PE TR I Y C P G Y F QLGG ------ R R F R C WK RG GHG RV DLRKAI EE SC D VYFYQL A L R LG I DK IA E Y AK RFGFGQ KTGID 396
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 362 LPGEKSG TL PS P EWK MSKI G E PWYPGDT ILM SIGQGY LTA TP IE L LKLVSLV AN E G IF Y R PH V VK R I GS ------ KAVK P 435
Cdd:TIGR03423 397 LPGEKSG LV PS R EWK RKRF G Q PWYPGDT LNV SIGQGY VLV TP LQ L AVATAAL AN G G KL Y K PH L VK S I ED pdggvv RRTE P 476
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 436 E IETQVQ I DEKIWNFIKDA M V DV T sfkg N EKE dp GTA YHVFGDF PY RV AGKTGTA E ----------- A GSGA ---- P H SW 500
Cdd:TIGR03423 477 E VLRPLP I SPENLDVVREG M R DV V ---- N GPG -- GTA RRARLGL PY KM AGKTGTA Q vvslkqgekyd A EQIP erlr D H AL 550
570 580 590 600
....*....|....*....|....*....|....*....|
gi 490182649 501 FV G FAP AE NP EV A IV V M VEHGG Y GS G AA SQ IAR RVLEE Y F 540
Cdd:TIGR03423 551 FV A FAP YD NP KI A VA V I VEHGG G GS S AA AP IAR KIMDA Y L 590
FtsI
COG0768 Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
4-543
4.59e-177
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440531 [Multi-domain]
Cd Length: 568
Bit Score: 511.68
E-value: 4.59e-177
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 4 R L ILI L MA L S F V L IIMKA F QV Q IL E HEKHKKYIDLLQT R L V K IPAPRG K I ISSD G K VLA KDEV VY -- VL DP WLNS ----- 76
Cdd:COG0768 15 L L LFL L VL L L F L L LVGRL F YL Q VV E GDEYAELAEENRI R T V P IPAPRG L I YDRN G N VLA TNVP VY sl YA DP EEVK dpeet 94
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 77 IDE L K K - T GL f T PEE ILSLV K GE S --- IVI ---- DKAR A DV I SKA --- G MR V VMD Y R R K Y -- EP LA P HV V GYV NA ---- D 139
Cdd:COG0768 95 AEK L A K l L GL - D PEE LRKKL K KK S rfp VYL krnl SPEE A AR I RAL klp G VY V EAE Y K R Y Y py GE LA A HV L GYV GE ingg D 173
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 140 RA G VY G V E SV Y DEF L T GT D G VKM V F V EPS G - A I SSEVLRS PP K PG E D VT LTID TRI QK V AEE S L E K I ----- GNP G S V IL 213
Cdd:COG0768 174 GI G KS G L E KA Y EDL L R GT P G KRR V E V DAR G r V I RDLGEEK PP V PG K D LV LTID SDL QK I AEE A L K K A veeyk AKS G A V VV 253
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 214 S D VR TGEILA L AS F P EYN P QD F YE G ftkrewerfarn SPS PL I NRA ISSA Y S PGS SI K ILW A V AAL LN GV - D P EEKIN C R 292
Cdd:COG0768 254 M D PK TGEILA M AS Y P SFD P NL F VG G ------------ PDE PL R NRA VQGT Y E PGS TF K PFT A A AAL EE GV i T P DTTFD C P 321
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 293 G VFEYRN srgevv ARY RDW KEE GHG FTD L RK A IRV S C NV Y FY Q L G L K LG V DK MVEVA KK LSIFE KTGIDLPGE K SG T LPS 372
Cdd:COG0768 322 G YYRVGG ------ RTI RDW DRG GHG TLT L TE A LAK S S NV G FY K L A L R LG I DK LYDYL KK FGLGQ KTGIDLPGE A SG L LPS 395
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 373 P ewkmskig EP WYPG D T IL MSIGQG y L TA TP IE L LKLVSLV AN E G IFYR PH V VK R I GSKA ----- VK PE IETQ V q I DEKI 447
Cdd:COG0768 396 P -------- KR WYPG E T AT MSIGQG - L SV TP LQ L AQAYAAI AN G G VLVK PH L VK E I VDPD gevvk EE PE VLRR V - I SPET 465
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 448 WNFIKDA M VD V TS fkgnek E DP GTA YHVFGD f P YRVAGKTGTA EAGSGAPH -------- SW FVGFAPA E NP EV A IV V M VE 519
Cdd:COG0768 466 AETVREG M EG V VN ------ E PG GTA RRAAIP - G YRVAGKTGTA QVVDIGNG gyykgrhi AS FVGFAPA D NP RY A VA V V VE 538
570 580
....*....|....*....|....*..
gi 490182649 520 HG G --- YG SGA A SQIA R RVL E E Y FK L K 543
Cdd:COG0768 539 NP G gga YG GTV A APVF R EIM E A Y LR L L 565
PRK10795
PRK10795 penicillin-binding protein 2; Provisional
7-552
1.33e-96
penicillin-binding protein 2; Provisional
Pssm-ID: 236761 [Multi-domain]
Cd Length: 634
Bit Score: 307.08
E-value: 1.33e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 7 L ILMA L SF VLI I m KAFQV QI LEHEKHKKYIDLLQTR LV K I PAP RG K I ISSD G KV LA KDEVV Y V L DPWLNSI D E L KK T g L F 86
Cdd:PRK10795 27 L GILL L TG VLI A - NLYNL QI VRFTDYQTRSNENRIK LV P I APS RG I I YDRN G TP LA LNRTI Y Q L EMMPEKV D N L QQ T - L D 104
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 87 TPEEILS L VKGESIVID K A RA -------------- DVISK A GMR V --------- V MD Y R R K Y E P LAP --- HV V GYV N --- 137
Cdd:PRK10795 105 ALRSVVD L TDDDIAAFR K E RA rsrrftsipvktnl TEVQV A RFA V nqyrfpgve V KG Y Q R R Y Y P YGS alt HV I GYV S kin 184
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 138 ------------- A DR A ----- G VY G V E SV Y DEF L T G TD G VKM V F V EPS G AISSEVLRS PP KP G E D VT LT I D TRI Q KVA E 199
Cdd:PRK10795 185 dkdverldkegkl A NY A athdi G KL G I E RY Y EDV L H G KT G YEE V E V NNR G RVIRQLHEQ PP QA G H D IY LT L D LKL Q QYI E 264
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 200 ES L E ki G NPGS V ILS D V RTG E ILAL A S F P E Y N P QD F YE G FTKREWERFARNSPS PLINRA ISSA Y S P G S SI K ILW AV A AL 279
Cdd:PRK10795 265 TL L A -- G SRAA V VVT D P RTG G ILAL V S T P S Y D P NL F VD G ISSKDYSGLLNDPNR PLINRA TQGV Y P P A S TV K PYV AV S AL 342
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 280 LN GV - DPEEKINCR G VFEYRN S R gevv A RYRDWK EE GHG FTDLR K AIRV S CNVY FYQ LGLKL G V D KMV E VAK K LSIFEK T 358
Cdd:PRK10795 343 SA GV i TRNTSLFDP G WWQLPG S E ---- K RYRDWK KW GHG RLNVT K SLEE S ADTF FYQ VAYDM G I D RLS E WMG K FGYGHY T 418
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 359 GIDL PG E K SG TL P SP EWK MSKIGE PWY P GDTI LMS IGQGY L TATPI ELL K LVSLVA N E GI FYR PH VV -- KRIGS K A V -- K 434
Cdd:PRK10795 419 GIDL AE E R SG NM P TR EWK QKRFKK PWY Q GDTI PVG IGQGY W TATPI QMS K ALMTLI N D GI VKV PH LL ms TAEDG K Q V pw V 498
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 435 PEI E TQ V - Q I DEKI W NFI KD A M VD V TS f KG N ekedp GTA YHV F GDF PY RV A G K T GTA EAGSGAP --------------- H 498
Cdd:PRK10795 499 QPH E PP V g D I HSGY W EIA KD G M YG V AN - RP N ----- GTA HKY F ASA PY KI A A K S GTA QVFGLKA netynahkiaerlrd H 572
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....
gi 490182649 499 SWFVG FAP AE NP E VA IVVMV E H GG Y G S g A ASQ I A R RV L e EYFK L KESAQET P VS 552
Cdd:PRK10795 573 KLMTA FAP YN NP Q VA VAIIL E N GG A G P - A VGT I M R QI L - DHIM L GDNNTDL P AE 624
Transpeptidase
pfam00905 Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss: ...
209-537
5.05e-70
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.
Pssm-ID: 425939 [Multi-domain]
Cd Length: 296
Bit Score: 226.91
E-value: 5.05e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 209 GS VILS D VR TGE I LA LASF P E Y N P QD F Y egftkrewerfarnsp S PL I NRA IS S A Y S PGS SI K ILW A V AAL L NGV - D P E E 287
Cdd:pfam00905 1 GS AVVL D PK TGE V LA MVGK P S Y D P NG F I ---------------- G PL R NRA VT S R Y E PGS TF K PFT A L AAL D NGV l K P D E 64
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 288 K I NCRG v FEYRNS rgevv ARYR DW KEEGH G FTD LR K A IRV S C N V Y FYQ L GL KLG V DK MVEVA KK LSIFE KTGI D LPGE KS 367
Cdd:pfam00905 65 T I FDWP - GKQQGG ----- KSIG DW NQDQV G IGT LR Q A LEY S S N W Y MQK L AQ KLG A DK LRSYL KK FGYGN KTGI G LPGE NA 138
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 368 G T L PS pewkmskige P W YP G D T ILMS IG qgy LT A TP IELLKLVSLV AN E G IFYR PH V VK R I GS K a V K P EIETQVQ I DEKI 447
Cdd:pfam00905 139 G Y L TP ---------- Y W LE G A T ASFG IG --- LT I TP LQQAQAYAAI AN G G KLVP PH L VK S I ED K - V D P KVLNKLP I SKST 204
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 448 WNFI KD AMVD V tsfkgn EKEDP GT AY hv FGDFP Y R VAGKTGTA E -------- AGS GA PHS WFVG F APA E NP EV A IV V MVE 519
Cdd:pfam00905 205 AEKV KD MLRL V ------ VNDGT GT GT -- AAVPG Y K VAGKTGTA Q vagpkggg YYD GA QIG WFVG Y APA D NP KY A FA V LID 276
330 340
....*....|....*....|
gi 490182649 520 HGG -- YG SGA A SQ I ARRV LE 537
Cdd:pfam00905 277 DPK ry YG GKV A AP I FKDI LE 296
Name
Accession
Description
Interval
E-value
pbp2_mrdA
TIGR03423 penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ...
5-540
0e+00
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 274573 [Multi-domain]
Cd Length: 592
Bit Score: 528.63
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 5 LILI L MALS F VLIIMKA F QV Q ILEH E KHKKYIDLLQT RLV K IP A PRG K I ISSD G KV LA KDEVVYV L ------- D PWLNSI 77
Cdd:TIGR03423 5 VLGG L VLAL F GVLAARL F YL Q VIRG E EYATLSEDNRI RLV P IP P PRG L I LDRN G VL LA DNRPSFS L eivpekv D DLDATL 84
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 78 D E L K K TGLFT PE E I LSLV K G ------- E S I VI - DKARADVISK -------- A G MRVVMDYR R K Y -- EP LA P HV V GYV NA - 138
Cdd:TIGR03423 85 D R L A K LLDLD PE D I ARFL K E lkrsrrf E P I PL k SDLTEEEVAR favnqyrl P G VEIEARLK R Y Y py GE LA A HV L GYV GE i 164
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 139 ---------------- D RA G VY G V E SV Y DEF L T G TD G VKM V F V EPS G AISSEVL R S PP K PG E D VT LTID T R I Q KV AE ES L 202
Cdd:TIGR03423 165 needlerlepanyagg D YI G KS G I E KY Y EDE L R G KP G YRE V E V NAR G RVIRTLS R V PP V PG K D LV LTID A R L Q QA AE KA L 244
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 203 E ki G NP G S V ILS D V RTGEILA LA S F P EYN P QD F YE G FTKREWERFARNSPS PL I NRAI SSA Y S PGS SI K ILW A V AAL LN G 282
Cdd:TIGR03423 245 G -- G RR G A V VVM D P RTGEILA MV S T P SFD P NL F VD G ISSKDYKALLNDPDR PL L NRAI QGV Y P PGS TF K PVV A L AAL EE G 322
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 283 V - D PE EK I N C R G V F EYRN srgevv A R Y R D WK EE GHG FT DLRKAI RV SC N VYFYQL G L K LG V DK MV E V AK KLSIFE KTGID 361
Cdd:TIGR03423 323 V i T PE TR I Y C P G Y F QLGG ------ R R F R C WK RG GHG RV DLRKAI EE SC D VYFYQL A L R LG I DK IA E Y AK RFGFGQ KTGID 396
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 362 LPGEKSG TL PS P EWK MSKI G E PWYPGDT ILM SIGQGY LTA TP IE L LKLVSLV AN E G IF Y R PH V VK R I GS ------ KAVK P 435
Cdd:TIGR03423 397 LPGEKSG LV PS R EWK RKRF G Q PWYPGDT LNV SIGQGY VLV TP LQ L AVATAAL AN G G KL Y K PH L VK S I ED pdggvv RRTE P 476
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 436 E IETQVQ I DEKIWNFIKDA M V DV T sfkg N EKE dp GTA YHVFGDF PY RV AGKTGTA E ----------- A GSGA ---- P H SW 500
Cdd:TIGR03423 477 E VLRPLP I SPENLDVVREG M R DV V ---- N GPG -- GTA RRARLGL PY KM AGKTGTA Q vvslkqgekyd A EQIP erlr D H AL 550
570 580 590 600
....*....|....*....|....*....|....*....|
gi 490182649 501 FV G FAP AE NP EV A IV V M VEHGG Y GS G AA SQ IAR RVLEE Y F 540
Cdd:TIGR03423 551 FV A FAP YD NP KI A VA V I VEHGG G GS S AA AP IAR KIMDA Y L 590
FtsI
COG0768 Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
4-543
4.59e-177
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440531 [Multi-domain]
Cd Length: 568
Bit Score: 511.68
E-value: 4.59e-177
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 4 R L ILI L MA L S F V L IIMKA F QV Q IL E HEKHKKYIDLLQT R L V K IPAPRG K I ISSD G K VLA KDEV VY -- VL DP WLNS ----- 76
Cdd:COG0768 15 L L LFL L VL L L F L L LVGRL F YL Q VV E GDEYAELAEENRI R T V P IPAPRG L I YDRN G N VLA TNVP VY sl YA DP EEVK dpeet 94
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 77 IDE L K K - T GL f T PEE ILSLV K GE S --- IVI ---- DKAR A DV I SKA --- G MR V VMD Y R R K Y -- EP LA P HV V GYV NA ---- D 139
Cdd:COG0768 95 AEK L A K l L GL - D PEE LRKKL K KK S rfp VYL krnl SPEE A AR I RAL klp G VY V EAE Y K R Y Y py GE LA A HV L GYV GE ingg D 173
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 140 RA G VY G V E SV Y DEF L T GT D G VKM V F V EPS G - A I SSEVLRS PP K PG E D VT LTID TRI QK V AEE S L E K I ----- GNP G S V IL 213
Cdd:COG0768 174 GI G KS G L E KA Y EDL L R GT P G KRR V E V DAR G r V I RDLGEEK PP V PG K D LV LTID SDL QK I AEE A L K K A veeyk AKS G A V VV 253
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 214 S D VR TGEILA L AS F P EYN P QD F YE G ftkrewerfarn SPS PL I NRA ISSA Y S PGS SI K ILW A V AAL LN GV - D P EEKIN C R 292
Cdd:COG0768 254 M D PK TGEILA M AS Y P SFD P NL F VG G ------------ PDE PL R NRA VQGT Y E PGS TF K PFT A A AAL EE GV i T P DTTFD C P 321
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 293 G VFEYRN srgevv ARY RDW KEE GHG FTD L RK A IRV S C NV Y FY Q L G L K LG V DK MVEVA KK LSIFE KTGIDLPGE K SG T LPS 372
Cdd:COG0768 322 G YYRVGG ------ RTI RDW DRG GHG TLT L TE A LAK S S NV G FY K L A L R LG I DK LYDYL KK FGLGQ KTGIDLPGE A SG L LPS 395
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 373 P ewkmskig EP WYPG D T IL MSIGQG y L TA TP IE L LKLVSLV AN E G IFYR PH V VK R I GSKA ----- VK PE IETQ V q I DEKI 447
Cdd:COG0768 396 P -------- KR WYPG E T AT MSIGQG - L SV TP LQ L AQAYAAI AN G G VLVK PH L VK E I VDPD gevvk EE PE VLRR V - I SPET 465
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 448 WNFIKDA M VD V TS fkgnek E DP GTA YHVFGD f P YRVAGKTGTA EAGSGAPH -------- SW FVGFAPA E NP EV A IV V M VE 519
Cdd:COG0768 466 AETVREG M EG V VN ------ E PG GTA RRAAIP - G YRVAGKTGTA QVVDIGNG gyykgrhi AS FVGFAPA D NP RY A VA V V VE 538
570 580
....*....|....*....|....*..
gi 490182649 520 HG G --- YG SGA A SQIA R RVL E E Y FK L K 543
Cdd:COG0768 539 NP G gga YG GTV A APVF R EIM E A Y LR L L 565
PRK10795
PRK10795 penicillin-binding protein 2; Provisional
7-552
1.33e-96
penicillin-binding protein 2; Provisional
Pssm-ID: 236761 [Multi-domain]
Cd Length: 634
Bit Score: 307.08
E-value: 1.33e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 7 L ILMA L SF VLI I m KAFQV QI LEHEKHKKYIDLLQTR LV K I PAP RG K I ISSD G KV LA KDEVV Y V L DPWLNSI D E L KK T g L F 86
Cdd:PRK10795 27 L GILL L TG VLI A - NLYNL QI VRFTDYQTRSNENRIK LV P I APS RG I I YDRN G TP LA LNRTI Y Q L EMMPEKV D N L QQ T - L D 104
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 87 TPEEILS L VKGESIVID K A RA -------------- DVISK A GMR V --------- V MD Y R R K Y E P LAP --- HV V GYV N --- 137
Cdd:PRK10795 105 ALRSVVD L TDDDIAAFR K E RA rsrrftsipvktnl TEVQV A RFA V nqyrfpgve V KG Y Q R R Y Y P YGS alt HV I GYV S kin 184
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 138 ------------- A DR A ----- G VY G V E SV Y DEF L T G TD G VKM V F V EPS G AISSEVLRS PP KP G E D VT LT I D TRI Q KVA E 199
Cdd:PRK10795 185 dkdverldkegkl A NY A athdi G KL G I E RY Y EDV L H G KT G YEE V E V NNR G RVIRQLHEQ PP QA G H D IY LT L D LKL Q QYI E 264
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 200 ES L E ki G NPGS V ILS D V RTG E ILAL A S F P E Y N P QD F YE G FTKREWERFARNSPS PLINRA ISSA Y S P G S SI K ILW AV A AL 279
Cdd:PRK10795 265 TL L A -- G SRAA V VVT D P RTG G ILAL V S T P S Y D P NL F VD G ISSKDYSGLLNDPNR PLINRA TQGV Y P P A S TV K PYV AV S AL 342
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 280 LN GV - DPEEKINCR G VFEYRN S R gevv A RYRDWK EE GHG FTDLR K AIRV S CNVY FYQ LGLKL G V D KMV E VAK K LSIFEK T 358
Cdd:PRK10795 343 SA GV i TRNTSLFDP G WWQLPG S E ---- K RYRDWK KW GHG RLNVT K SLEE S ADTF FYQ VAYDM G I D RLS E WMG K FGYGHY T 418
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 359 GIDL PG E K SG TL P SP EWK MSKIGE PWY P GDTI LMS IGQGY L TATPI ELL K LVSLVA N E GI FYR PH VV -- KRIGS K A V -- K 434
Cdd:PRK10795 419 GIDL AE E R SG NM P TR EWK QKRFKK PWY Q GDTI PVG IGQGY W TATPI QMS K ALMTLI N D GI VKV PH LL ms TAEDG K Q V pw V 498
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 435 PEI E TQ V - Q I DEKI W NFI KD A M VD V TS f KG N ekedp GTA YHV F GDF PY RV A G K T GTA EAGSGAP --------------- H 498
Cdd:PRK10795 499 QPH E PP V g D I HSGY W EIA KD G M YG V AN - RP N ----- GTA HKY F ASA PY KI A A K S GTA QVFGLKA netynahkiaerlrd H 572
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....
gi 490182649 499 SWFVG FAP AE NP E VA IVVMV E H GG Y G S g A ASQ I A R RV L e EYFK L KESAQET P VS 552
Cdd:PRK10795 573 KLMTA FAP YN NP Q VA VAIIL E N GG A G P - A VGT I M R QI L - DHIM L GDNNTDL P AE 624
spoVD_pbp
TIGR02214 stage V sporulation protein D; This model describes the spoVD subfamily of homologs of the ...
6-540
4.68e-81
stage V sporulation protein D; This model describes the spoVD subfamily of homologs of the cell division protein FtsI, a penicillin binding protein. This subfamily is restricted to Bacillus subtilis and related Gram-positive species with known or suspected endospore formation capability. In these species, the functional equivalent of FtsI is desginated PBP-2B, a paralog of spoVD. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Sporulation and germination]
Pssm-ID: 131269 [Multi-domain]
Cd Length: 636
Bit Score: 266.29
E-value: 4.68e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 6 ILI LMALS F VLI I MKA F Q VQ ILEHEKH K KYIDLLQ TR LVK I P A P RG K I ISSD G KV LA KDEV V YVL D PWLNS I -------- 77
Cdd:TIGR02214 5 ILI SFTAL F LIL I LRL F Y VQ VFRGSFY K EMAEDQW TR EIP I E A K RG R I LDRN G NE LA VSVS V DRV D LDPAT I rknkepkq 84
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 78 ---- D EL KKTGLFTP E EILS - LV K GE S IV -------- I D K AR A D --- VISKA G MR V VM D YR R K Y E -- PLAP HV V G YV N A D 139
Cdd:TIGR02214 85 reia N EL ARVLEMDK E KVFK r IT K KN S PF vsaklgrk I E K DK A E kvr NLKLN G VS V SP D SK R Y Y P ng DFLS HV L G FT N S D 164
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 140 RA G VY G V E SV YD EF L T G TD GV KMVFVEPSGA -- ISSEVLRSP P KP G E D VT LTID TR IQ KVA E ESLE K I --- GN P GS V -- I 212
Cdd:TIGR02214 165 GR G LE G L E LY YD KE L R G LP GV RVAEYDANSL el PYAQHAYVK P VD G H D LV LTID EN IQ YII E READ K A lre RK P KG V si I 244
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 213 LSDVRT GEIL ALASF P E Y N P Q D FYEGF tkrew ERF AR N spspli NRA I S S AY S PGS SI KI LWAV AA L - LNG V DPEE K INC 291
Cdd:TIGR02214 245 VMNPKN GEIL GMSNR P T Y D P N D PRDKS ----- PDT AR R ------ NRA V S D AY E PGS TF KI ITSS AA M e EGI V KESD K FYD 313
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 292 R G VFEYRN srgevv ARYRD WK EE GHG FTDLRKAIRV SCN VY F YQ LG LK LG VD K MVEVAKKLSIFE KTGIDLPGE KS G T L P 371
Cdd:TIGR02214 314 D G SATVGG ------ KKIKC WK PG GHG SQTFPEVVQN SCN PG F IE LG MR LG AE K LNNYILAFGFGS KTGIDLPGE AA G I L V 387
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 372 SPE wkms K I G epwy P G D TILM S I GQ G y L T A TPI E L LKL V SL VAN E G IFYR PH VV K R I ---- GSKAVK --- PE IET QV q ID 444
Cdd:TIGR02214 388 PKK ---- K V G ---- P V D LATI S F GQ A - N T V TPI Q L MTA V NA VAN G G KLIQ PH IM K E I sdsq NNAVDQ tfe PE VKR QV - VS 457
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 445 EKIWNFIKD A MVD V T S f KG N ekedp G TAYHVF G dfp YRV A GKTGTA EA ------- GS G APHSW FVGFAPA EN P E VA IV V M 517
Cdd:TIGR02214 458 KETTQKLRL A LET V V S - KG S ----- G KNAFIE G --- YRV G GKTGTA QK vkpnggy ME G EYIVS FVGFAPA DD P A VA VL V V 528
570 580
....*....|....*....|....*..
gi 490182649 518 V EH -- G G -- Y G SGA A SQIARR V LEEYF 540
Cdd:TIGR02214 529 V DN pk G V qq F G GLV A APVFGS V FNDIL 555
Transpeptidase
pfam00905 Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss: ...
209-537
5.05e-70
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.
Pssm-ID: 425939 [Multi-domain]
Cd Length: 296
Bit Score: 226.91
E-value: 5.05e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 209 GS VILS D VR TGE I LA LASF P E Y N P QD F Y egftkrewerfarnsp S PL I NRA IS S A Y S PGS SI K ILW A V AAL L NGV - D P E E 287
Cdd:pfam00905 1 GS AVVL D PK TGE V LA MVGK P S Y D P NG F I ---------------- G PL R NRA VT S R Y E PGS TF K PFT A L AAL D NGV l K P D E 64
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 288 K I NCRG v FEYRNS rgevv ARYR DW KEEGH G FTD LR K A IRV S C N V Y FYQ L GL KLG V DK MVEVA KK LSIFE KTGI D LPGE KS 367
Cdd:pfam00905 65 T I FDWP - GKQQGG ----- KSIG DW NQDQV G IGT LR Q A LEY S S N W Y MQK L AQ KLG A DK LRSYL KK FGYGN KTGI G LPGE NA 138
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 368 G T L PS pewkmskige P W YP G D T ILMS IG qgy LT A TP IELLKLVSLV AN E G IFYR PH V VK R I GS K a V K P EIETQVQ I DEKI 447
Cdd:pfam00905 139 G Y L TP ---------- Y W LE G A T ASFG IG --- LT I TP LQQAQAYAAI AN G G KLVP PH L VK S I ED K - V D P KVLNKLP I SKST 204
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 448 WNFI KD AMVD V tsfkgn EKEDP GT AY hv FGDFP Y R VAGKTGTA E -------- AGS GA PHS WFVG F APA E NP EV A IV V MVE 519
Cdd:pfam00905 205 AEKV KD MLRL V ------ VNDGT GT GT -- AAVPG Y K VAGKTGTA Q vagpkggg YYD GA QIG WFVG Y APA D NP KY A FA V LID 276
330 340
....*....|....*....|
gi 490182649 520 HGG -- YG SGA A SQ I ARRV LE 537
Cdd:pfam00905 277 DPK ry YG GKV A AP I FKDI LE 296
PRK15105
PRK15105 peptidoglycan synthase FtsI; Provisional
8-529
4.22e-38
peptidoglycan synthase FtsI; Provisional
Pssm-ID: 185060 [Multi-domain]
Cd Length: 578
Bit Score: 148.04
E-value: 4.22e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 8 IL M AL S F V L I im KAFQV Q ILEHEKHKKYI D LLQT R LVKIPAP RG K I ISSD G KV LA KDEV V YVL dp W LNSIDELKKT G LFT 87
Cdd:PRK15105 30 IL L AL V F L L G -- RVAWL Q VINPDMLVREG D MRSL R VQEVSTS RG M I TDRS G RP LA VSVP V KAI -- W ADPKEVHDAG G ISV 105
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 88 PEEILS L VKGES I VI D KAR A DVISKAGM R VVM ---------- DY -------------- R R K Y E P --- LAP H VV G YV N A D R 140
Cdd:PRK15105 106 DDRWKA L ADALN I PL D QLS A RINANPKG R FIY larqvnpdma DY ikklklpgihlree S R R Y Y P sge VTA H LI G FT N V D S 185
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 141 A G VY GVE SVY D EF LTG TD G VKM V FVEPS G AISSEVLRSPPKPGEDVT L T ID T R I Q KVAEES L EKI ----- GNP GS VI L S D 215
Cdd:PRK15105 186 Q G IE GVE KSF D KW LTG QP G ERI V RKDRY G RVIEDISSTDSQAAHNLA L S ID E R L Q ALVYRE L NNA vafnk AES GS AV L V D 265
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 216 V R TGE I LA L A SF P E YNP QDFYE gf T KREWE R farnspspli NRAI SSAYS PGS SI K ILWAVA AL LN GV DP E EKI nc RGVF 295
Cdd:PRK15105 266 V N TGE V LA M A NS P S YNP NNLSG -- T PKDAM R ---------- NRAI TDVFE PGS TV K PMVVMT AL QR GV VK E NSV -- LNTV 331
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 296 E YR NSRG E V -- VARY RDWKEE G hgftdlrk AIRV S C NV YFYQ L G L KLGVDKM V EVAKKLSIFEK T GID L P GE K SG TL P SP 373
Cdd:PRK15105 332 P YR INGH E I kd VARY SELTLT G -------- VLQK S S NV GVSK L A L AMPSSAL V DTYSRFGLGKA T NLG L V GE R SG LY P QK 403
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 374 ewkmskig EP W YPGDTILM S I G Q G y L TA TP IE L LKLVSLVANE GI f YRP HVVKR igska V K P EIETQVQID E K I WNFIKD 453
Cdd:PRK15105 404 -------- QR W SDIERATF S F G Y G - L MV TP LQ L ARVYATIGSY GI - YRP LSITK ----- V D P PVPGERVFP E S I VRTVVH 468
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 454 A M VD V TSFK G N ekedp G TAYHVF G dfp YR V A G KTGTA - EA G SGAPH ----- SWFV G F APA EN P EV A I VV MV --- EH G G Y G 524
Cdd:PRK15105 469 M M ES V ALPG G G ----- G VKAAIK G --- YR I A I KTGTA k KV G PDGRY inkyi AYTA G V APA SQ P RF A L VV VI ndp QA G K Y Y 540
....*
gi 490182649 525 S GA A S 529
Cdd:PRK15105 541 G GA V S 545
MrcB
COG0744 Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall ...
186-553
1.03e-36
Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440507 [Multi-domain]
Cd Length: 630
Bit Score: 144.29
E-value: 1.03e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 186 VTL T I D TRI QK V AE ESLEKI --- G N P ---- GSVILS D VR TGE I LA LASFPE Y NPQD F yegftkrewerfarnspspli NR 258
Cdd:COG0744 297 IYT T L D PKL QK A AE KAVKNV lpe G K P gglq AALVVV D PK TGE V LA MVGGRD Y GKSQ F --------------------- NR 355
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 259 A ISSAYS PGS SI K ILWAV AAL LN G VD P EEKINCR ------ G VFEYR N SR G evvaryrdwke EGH G FTD LR K A IRV S C N VY 332
Cdd:COG0744 356 A TQAKRQ PGS TF K PFVYA AAL EQ G YT P ATTVDDE pvtfpg G GWSPK N YD G ----------- RYR G PVT LR E A LAN S L N TP 424
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 333 FYQ L GLKL G V DK M V EV A KK L sifekt GI D lpg EKSGTL PS pewkmskigepwypgdtil MSI G QGYL ta T P I E LLKLVSL 412
Cdd:COG0744 425 AVR L AQEV G L DK V V DT A RR L ------ GI T --- SPLDPN PS ------------------- LAL G TSEV -- S P L E MASAYAT 474
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 413 V AN E G IFYR PH VVKRI ---- G SKAVKPEIETQVQ I DEKIWNFIK D AMV DV TS fkgneked P GT AYHV - FGDF P yr VAGKT 487
Cdd:COG0744 475 F AN G G VYVE PH AITKV tdad G KVLYEAKPKCEQV I SPEVAYLMT D MLQ DV VT -------- S GT GRAA r LPGR P -- VAGKT 544
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490182649 488 GT AE ags GAPHS WFVG F apae N P EVAIV V M V ------- EHGGY G SGAASQ I A R RVL E EYFKLKESAQETPV S S 553
Cdd:COG0744 545 GT TN --- DNRDA WFVG Y ---- T P QLVTA V W V gnddnsp MGYVT G GSLPAP I W R DFM E AALEGLPVEDFPKP S G 610
PBP_1a_fam
TIGR02074 penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan ...
180-541
7.86e-23
penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273955 [Multi-domain]
Cd Length: 531
Bit Score: 101.95
E-value: 7.86e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 180 PKP G EDVTL T I D TRI QK V AE ES L EKIGN ---------- PGSVILS D VR TG EIL AL ASFPE Y NPQD F yegftkrewerfar 249
Cdd:TIGR02074 218 YTG G LKIYT T L D LDA QK A AE KV L NTGLR vagrrdgddl QAALVAI D PD TG AVR AL VGGRD Y GKSQ F -------------- 283
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 250 nspspli NRA ISSAYS PGS SI K ILWAV AAL LN G VD P E ------- EKI N CR G VFEYR N SR G evva R YR dwkeegh G FTD LR 322
Cdd:TIGR02074 284 ------- NRA TQAKRQ PGS TF K PFVYA AAL EK G LT P A tivndep ITY N GN G PWSPK N YG G ---- G YR ------- G NVT LR 345
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 323 K A IRV S C N VYFYQ L GLKL G V DK M V EV AK KL sifekt GI DL P GEKS gtlpspewkmskigepwypgdtil M S IGQ G YLTAT 402
Cdd:TIGR02074 346 Q A LAQ S R N IPAVR L LQEV G L DK V V AL AK RF ------ GI TS P LDPV ------------------------ L S LAL G TVEVS 395
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 403 P I E LLKLVSLV AN E G IFYR PH VVKR I GSKA ------ V KP E i E TQV q I DEKIWNFIK D AMVD V T sfkgneke DP GT AY -- H 474
Cdd:TIGR02074 396 P L E MASAYAVF AN G G KYVE PH GIRK I VDRD gkviye N KP K - T TQV - I SPATAYIMT D MLKG V V -------- ES GT GR sa R 465
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490182649 475 VF G dfp YR VAGKTGT A eag SGAPHS WFVG F apae N P EVAIV V M V ------ EH G -- G Y G S G A A SQ I A R RVLE E YF K 541
Cdd:TIGR02074 466 LP G --- RP VAGKTGT T --- QNWRDA WFVG Y ---- T P YYVTA V W V gyddkk TL G ks G T G G G L A AP I W R DFMA E AL K 530
PBP_dimer
pfam03717 Penicillin-binding Protein dimerization domain; This domain is found at the N terminus of ...
45-174
3.39e-12
Penicillin-binding Protein dimerization domain; This domain is found at the N terminus of Class B High Molecular Weight Penicillin-Binding Proteins. Its function has not been precisely defined, but is strongly implicated in PBP polymerization. The domain forms a largely disordered 'sugar tongs' structure.
Pssm-ID: 427460 [Multi-domain]
Cd Length: 178
Bit Score: 65.04
E-value: 3.39e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 45 K IPAPRG K I ISSD G K VLA KDEV VY V L --------- DPW L NSIDE L K K tg L FTPE E I L SLVK ------------- GESI VI 102
Cdd:pfam03717 1 P IPAPRG E I YDRN G V VLA TNKP VY S L titpsklkk ADA L KTALK L A K -- L LSNY E D L DDED lterflkmnsyks YYPV VI 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490182649 103 ---- DKARADV I SKA ----- G MRVVM D YR R K Y -- EP LA P H VV GYV NA ----------------- D RA G VY G V E SV Y DEF L 154
Cdd:pfam03717 79 kknl SEEEVAR I EEN llelp G VSIET D PV R Y Y py GE LA A H LL GYV GE iteeelekyldkgysrg D LV G KS G L E KQ Y ESV L 158
170 180
....*....|....*....|
gi 490182649 155 T G T DGV KM V F V EPS G AISS E 174
Cdd:pfam03717 159 R G K DGV RQ V E V DAL G RVIR E 178
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
