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Conserved domains on  [gi|490009574|ref|WP_003912368|]
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MULTISPECIES: cell division-associated protein FhaA [Mycobacterium]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
FHA_FhaA-like cd22668
forkhead associated (FHA) domain found in Mycobacterium tuberculosis FHA domain-containing ...
436-525 6.06e-49

forkhead associated (FHA) domain found in Mycobacterium tuberculosis FHA domain-containing protein FhaA and similar proteins; FhaA regulates cell growth and peptidoglycan synthesis by binding to MviN. It may inhibit the late stages of peptidoglycan synthesis. It contains an FHA domain, which is a small phosphopeptide recognition module.


:

Pssm-ID: 438720 [Multi-domain]  Cd Length: 91  Bit Score: 163.79  E-value: 6.06e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574 436 VTLQLDDGSGRTYQLREGSNIIGRGQDAQFRLPDTGVSRRHLEIRWDGQVALLADLNSTNGTTVNNAPVQ-EWQLADGDV 514
Cdd:cd22668    1 VTLQLDDGSGRVYQLREGSNIIGRGSDADFRLPDTGVSRRHAEIRWDGQVAHLTDLGSTNGTTVNNAPVTpEWRLADGDV 80
                         90
                 ....*....|.
gi 490009574 515 IRLGHSEIIVR 525
Cdd:cd22668   81 ITLGHSEIIVR 91
FhaA_N pfam12401
FhaA, N-terminal domain; This domain can be found at the N terminus of FHA domain-containing ...
8-122 6.13e-47

FhaA, N-terminal domain; This domain can be found at the N terminus of FHA domain-containing protein Fha from Mycobacterium tuberculosis. The FHA (Fork Head Associated) domain is a phosphopeptide- specific binding domain that enables the protein to specifically bind to sequences containing phosphothreonine. FhaA is one of the major substrates of Ser/Thr protein kinases (STPK) and plays a role in the regulation of cell growth and peptidoglycan synthesis by binding to MviN. It may inhibit the late stages of peptidoglycan synthesis.


:

Pssm-ID: 463562  Cd Length: 115  Bit Score: 159.22  E-value: 6.13e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574    8 VQRVERKLEQTVGDAFARIFGGSIVPQEVEALLRREAADGIQSLQGNRLLAPNEYIITLGVHDFEKLGADPELKSTGFAR 87
Cdd:pfam12401   1 LDRFERRLERAVEGAFARVFGGEVQPVEIAKALRREMDDNARVVSGGRVLAPNVYTVELSPDDYERLAPWGDTLADELAD 80
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 490009574   88 DLADYIQEQGWQTYGDVVVRFEQSSNLHTGQFRAR 122
Cdd:pfam12401  81 YLAEHAREQGYTFVGPVVVRFEEDESLHTGQFRVR 115
dnaA super family cl42516
chromosomal replication initiator protein DnaA;
178-377 1.29e-06

chromosomal replication initiator protein DnaA;


The actual alignment was detected with superfamily member PRK14086:

Pssm-ID: 455861 [Multi-domain]  Cd Length: 617  Bit Score: 50.98  E-value: 1.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574 178 RYARPQEDPRGGPDPQGGSDPRGGYPpetgGYPPQPGYPRPRHPDQGD-YPE-QIGYPDQGGYPEQRGYPeqrGYPDQRG 255
Cdd:PRK14086  94 EPAPPPPHARRTSEPELPRPGRRPYE----GYGGPRADDRPPGLPRQDqLPTaRPAYPAYQQRPEPGAWP---RAADDYG 166
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574 256 YQdqgrgypdQGQGGYPPPYEQRPPVSPGPAAGYGAPGYDQGYRQSGGYGPSPGGGQPGYGGYGEYGRGPARHEEGS-YV 334
Cdd:PRK14086 167 WQ--------QQRLGFPPRAPYASPASYAPEQERDREPYDAGRPEYDQRRRDYDHPRPDWDRPRRDRTDRPEPPPGAgHV 238
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 490009574 335 PSGPPGPPE-----QRPAYPDQGGYDQGYQQGATTYGRQDYGGGADYT 377
Cdd:PRK14086 239 HRGGPGPPErddapVVPIRPSAPGPLAAQPAPAPGPGEPTARLNPKYT 286
 
Name Accession Description Interval E-value
FHA_FhaA-like cd22668
forkhead associated (FHA) domain found in Mycobacterium tuberculosis FHA domain-containing ...
436-525 6.06e-49

forkhead associated (FHA) domain found in Mycobacterium tuberculosis FHA domain-containing protein FhaA and similar proteins; FhaA regulates cell growth and peptidoglycan synthesis by binding to MviN. It may inhibit the late stages of peptidoglycan synthesis. It contains an FHA domain, which is a small phosphopeptide recognition module.


Pssm-ID: 438720 [Multi-domain]  Cd Length: 91  Bit Score: 163.79  E-value: 6.06e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574 436 VTLQLDDGSGRTYQLREGSNIIGRGQDAQFRLPDTGVSRRHLEIRWDGQVALLADLNSTNGTTVNNAPVQ-EWQLADGDV 514
Cdd:cd22668    1 VTLQLDDGSGRVYQLREGSNIIGRGSDADFRLPDTGVSRRHAEIRWDGQVAHLTDLGSTNGTTVNNAPVTpEWRLADGDV 80
                         90
                 ....*....|.
gi 490009574 515 IRLGHSEIIVR 525
Cdd:cd22668   81 ITLGHSEIIVR 91
FhaA_N pfam12401
FhaA, N-terminal domain; This domain can be found at the N terminus of FHA domain-containing ...
8-122 6.13e-47

FhaA, N-terminal domain; This domain can be found at the N terminus of FHA domain-containing protein Fha from Mycobacterium tuberculosis. The FHA (Fork Head Associated) domain is a phosphopeptide- specific binding domain that enables the protein to specifically bind to sequences containing phosphothreonine. FhaA is one of the major substrates of Ser/Thr protein kinases (STPK) and plays a role in the regulation of cell growth and peptidoglycan synthesis by binding to MviN. It may inhibit the late stages of peptidoglycan synthesis.


Pssm-ID: 463562  Cd Length: 115  Bit Score: 159.22  E-value: 6.13e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574    8 VQRVERKLEQTVGDAFARIFGGSIVPQEVEALLRREAADGIQSLQGNRLLAPNEYIITLGVHDFEKLGADPELKSTGFAR 87
Cdd:pfam12401   1 LDRFERRLERAVEGAFARVFGGEVQPVEIAKALRREMDDNARVVSGGRVLAPNVYTVELSPDDYERLAPWGDTLADELAD 80
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 490009574   88 DLADYIQEQGWQTYGDVVVRFEQSSNLHTGQFRAR 122
Cdd:pfam12401  81 YLAEHAREQGYTFVGPVVVRFEEDESLHTGQFRVR 115
FHA COG1716
Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];
435-526 1.60e-29

Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];


Pssm-ID: 441322 [Multi-domain]  Cd Length: 96  Bit Score: 111.59  E-value: 1.60e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574 435 SVTLQLDDGS--GRTYQLREGSNIIGRGQDAQFRLPDTGVSRRHLEIRWDGQVALLADLNSTNGTTVNNAPV-QEWQLAD 511
Cdd:COG1716    1 MARLVVLEGPlaGRRFPLDGGPLTIGRAPDNDIVLDDPTVSRRHARIRRDGGGWVLEDLGSTNGTFVNGQRVtEPAPLRD 80
                         90
                 ....*....|....*
gi 490009574 512 GDVIRLGHSEIIVRM 526
Cdd:COG1716   81 GDVIRLGKTELRFRL 95
FHA pfam00498
FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.
456-517 1.09e-16

FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.


Pssm-ID: 459831 [Multi-domain]  Cd Length: 66  Bit Score: 74.53  E-value: 1.09e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490009574  456 IIGRGQDAQFRLPDTGVSRRHLEIRWDGQVAL-LADLNSTNGTTVNNAPVQE--WQLADGDVIRL 517
Cdd:pfam00498   2 TIGRSPDCDIVLDDPSVSRRHAEIRYDGGGRFyLEDLGSTNGTFVNGQRLGPepVRLKDGDVIRL 66
FHA smart00240
Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear ...
456-504 1.14e-11

Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain.


Pssm-ID: 214578 [Multi-domain]  Cd Length: 52  Bit Score: 59.50  E-value: 1.14e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 490009574   456 IIGRG-QDAQFRLPDTGVSRRHLEIRWDGQ-VALLADLNSTNGTTVNNAPV 504
Cdd:smart00240   2 TIGRSsEDCDIQLDGPSISRRHAVIVYDGGgRFYLIDLGSTNGTFVNGKRI 52
VI_FHA TIGR03354
type VI secretion system FHA domain protein; Members of this protein family are FHA ...
439-527 2.50e-10

type VI secretion system FHA domain protein; Members of this protein family are FHA (forkhead-associated) domain-containing proteins that are part of type VI secretion loci in a considerable number of bacteria, most of which are known pathogens. Species include Pseudomonas aeruginosa PAO1, Aeromonas hydrophila, Yersinia pestis, Burkholderia mallei, etc. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 274537 [Multi-domain]  Cd Length: 396  Bit Score: 62.39  E-value: 2.50e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574  439 QLDDGSGRTYQLREGSNIIGRGQDAQFRLPDTG--VSRRHLEIRWDGQVALLADLnSTNGTTVNNAPVQ-----EWQLAD 511
Cdd:TIGR03354  10 QLTPGIAAQKTFGTNGGTIGRSEDCDWVLPDPErhVSGRHARIRYRDGAYLLTDL-STNGVFLNGSGSPlgrgnPVRLEQ 88
                          90
                  ....*....|....*.
gi 490009574  512 GDVIRLGHSEIIVRMH 527
Cdd:TIGR03354  89 GDRLRLGDYEIRVSLG 104
dnaA PRK14086
chromosomal replication initiator protein DnaA;
178-377 1.29e-06

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 50.98  E-value: 1.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574 178 RYARPQEDPRGGPDPQGGSDPRGGYPpetgGYPPQPGYPRPRHPDQGD-YPE-QIGYPDQGGYPEQRGYPeqrGYPDQRG 255
Cdd:PRK14086  94 EPAPPPPHARRTSEPELPRPGRRPYE----GYGGPRADDRPPGLPRQDqLPTaRPAYPAYQQRPEPGAWP---RAADDYG 166
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574 256 YQdqgrgypdQGQGGYPPPYEQRPPVSPGPAAGYGAPGYDQGYRQSGGYGPSPGGGQPGYGGYGEYGRGPARHEEGS-YV 334
Cdd:PRK14086 167 WQ--------QQRLGFPPRAPYASPASYAPEQERDREPYDAGRPEYDQRRRDYDHPRPDWDRPRRDRTDRPEPPPGAgHV 238
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 490009574 335 PSGPPGPPE-----QRPAYPDQGGYDQGYQQGATTYGRQDYGGGADYT 377
Cdd:PRK14086 239 HRGGPGPPErddapVVPIRPSAPGPLAAQPAPAPGPGEPTARLNPKYT 286
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
140-373 8.28e-03

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 38.84  E-value: 8.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574  140 RPQSNHAFGAEPGvAPMSDNssyRGGQGQGRPDEYYDDRyARPQEDPRGGPDPQGGSDPRGGYPPETGGYPPQPGYPRPR 219
Cdd:pfam09606  95 RPQMMGPMGPGPG-GPMGQQ---MGGPGTASNLLASLGR-PQMPMGGAGFPSQMSRVGRMQPGGQAGGMMQPSSGQPGSG 169
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574  220 HPDQGDYPEQIGYPDQGGYPEQRGYPEQRGYPDQRGyqDQGRGYPDQGQGGYPppyeQRPPVSPGPAAGYGAPGYDQGYR 299
Cdd:pfam09606 170 TPNQMGPNGGPGQGQAGGMNGGQQGPMGGQMPPQMG--VPGMPGPADAGAQMG----QQAQANGGMNPQQMGGAPNQVAM 243
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490009574  300 QSGGYGPSPGGGQPGYGGYGEYGRGPA-RHEEGSYVPSGPPGPPEQRPAY--PDQGGYDQGYQQGATTYGRQDYGGG 373
Cdd:pfam09606 244 QQQQPQQQGQQSQLGMGINQMQQMPQGvGGGAGQGGPGQPMGPPGQQPGAmpNVMSIGDQNNYQQQQTRQQQQQQGG 320
 
Name Accession Description Interval E-value
FHA_FhaA-like cd22668
forkhead associated (FHA) domain found in Mycobacterium tuberculosis FHA domain-containing ...
436-525 6.06e-49

forkhead associated (FHA) domain found in Mycobacterium tuberculosis FHA domain-containing protein FhaA and similar proteins; FhaA regulates cell growth and peptidoglycan synthesis by binding to MviN. It may inhibit the late stages of peptidoglycan synthesis. It contains an FHA domain, which is a small phosphopeptide recognition module.


Pssm-ID: 438720 [Multi-domain]  Cd Length: 91  Bit Score: 163.79  E-value: 6.06e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574 436 VTLQLDDGSGRTYQLREGSNIIGRGQDAQFRLPDTGVSRRHLEIRWDGQVALLADLNSTNGTTVNNAPVQ-EWQLADGDV 514
Cdd:cd22668    1 VTLQLDDGSGRVYQLREGSNIIGRGSDADFRLPDTGVSRRHAEIRWDGQVAHLTDLGSTNGTTVNNAPVTpEWRLADGDV 80
                         90
                 ....*....|.
gi 490009574 515 IRLGHSEIIVR 525
Cdd:cd22668   81 ITLGHSEIIVR 91
FhaA_N pfam12401
FhaA, N-terminal domain; This domain can be found at the N terminus of FHA domain-containing ...
8-122 6.13e-47

FhaA, N-terminal domain; This domain can be found at the N terminus of FHA domain-containing protein Fha from Mycobacterium tuberculosis. The FHA (Fork Head Associated) domain is a phosphopeptide- specific binding domain that enables the protein to specifically bind to sequences containing phosphothreonine. FhaA is one of the major substrates of Ser/Thr protein kinases (STPK) and plays a role in the regulation of cell growth and peptidoglycan synthesis by binding to MviN. It may inhibit the late stages of peptidoglycan synthesis.


Pssm-ID: 463562  Cd Length: 115  Bit Score: 159.22  E-value: 6.13e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574    8 VQRVERKLEQTVGDAFARIFGGSIVPQEVEALLRREAADGIQSLQGNRLLAPNEYIITLGVHDFEKLGADPELKSTGFAR 87
Cdd:pfam12401   1 LDRFERRLERAVEGAFARVFGGEVQPVEIAKALRREMDDNARVVSGGRVLAPNVYTVELSPDDYERLAPWGDTLADELAD 80
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 490009574   88 DLADYIQEQGWQTYGDVVVRFEQSSNLHTGQFRAR 122
Cdd:pfam12401  81 YLAEHAREQGYTFVGPVVVRFEEDESLHTGQFRVR 115
FHA COG1716
Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];
435-526 1.60e-29

Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];


Pssm-ID: 441322 [Multi-domain]  Cd Length: 96  Bit Score: 111.59  E-value: 1.60e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574 435 SVTLQLDDGS--GRTYQLREGSNIIGRGQDAQFRLPDTGVSRRHLEIRWDGQVALLADLNSTNGTTVNNAPV-QEWQLAD 511
Cdd:COG1716    1 MARLVVLEGPlaGRRFPLDGGPLTIGRAPDNDIVLDDPTVSRRHARIRRDGGGWVLEDLGSTNGTFVNGQRVtEPAPLRD 80
                         90
                 ....*....|....*
gi 490009574 512 GDVIRLGHSEIIVRM 526
Cdd:COG1716   81 GDVIRLGKTELRFRL 95
FHA cd00060
forkhead associated (FHA) domain superfamily; Forkhead-associated (FHA) domains are small ...
441-525 8.26e-26

forkhead associated (FHA) domain superfamily; Forkhead-associated (FHA) domains are small phosphopeptide recognition modules mostly found in eubacteria and eukaryotes. It is about 95-120 residues long that fold into an 11-stranded beta-sandwich. FHA domains can mediate the recognition of phosphorylated and non-phosphorylated substrates, as well as protein oligomerization. They specifically recognize threonine phosphorylation (pThr) accompanying activation of protein serine/threonine kinases. FHA domains show diverse ligand specificity. They may recognize the pTXXD motif, the pTXXI/L motif, and TQ clusters (singly and multiply phosphorylated). In eukaryotes, FHA superfamily members include forkhead-type transcription factors, as well as other signaling proteins, such as many regulatory proteins, kinases, phosphatases, motor proteins called kinesins, and metabolic enzymes. Many of them localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. FHA domains play important roles in human diseases, particularly in relation to DNA damage responses and cancers. In bacteria, FHA domain-containing proteins may participate in injection of viral proteins into host cells, transmembrane transporters, and cell division. FHA domain-containing proteins rarely include more than one copy of the domain. The only exception in eukaryotes is the checkpoint kinase Rad53 from Saccharomyces cerevisiae, which harbors two FHA domains (FHA1 and FHA2) flanking a central kinase domain. The two FHA domains recognize different phosphorylated targets and function independently from one another. In contrast, Mycobacterium tuberculosis ABC transporter Rv1747 contains two FHA domains but only one of them is essential for protein function.


Pssm-ID: 438714 [Multi-domain]  Cd Length: 92  Bit Score: 100.81  E-value: 8.26e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574 441 DDGSGRTYQLREGSNIIGRGQDAQFRLPDTGVSRRHLEIRWDGQVALLADLNSTNGTTVNNAPVQEW-QLADGDVIRLGH 519
Cdd:cd00060    7 GDGGGREFPLTKGVVTIGRSPDCDIVLDDPSVSRRHARIEVDGGGVYLEDLGSTNGTFVNGKRITPPvPLQDGDVIRLGD 86

                 ....*.
gi 490009574 520 SEIIVR 525
Cdd:cd00060   87 TTFRFE 92
FHA_EspA-like cd22698
forkhead associated (FHA) domain found in Myxococcus xanthus EspA and similar proteins; EspA ...
439-525 7.33e-17

forkhead associated (FHA) domain found in Myxococcus xanthus EspA and similar proteins; EspA is a histidine protein kinase with a fork head-associated (FHA) domain at the N-terminus and a receiver domain at the C-terminus. It functions as an inhibitor of sporulation during early fruiting body development while cells are aggregating into raised mounds. EspA is part of a two-component signal transduction system that regulates the timing of sporulation initiation. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438750 [Multi-domain]  Cd Length: 93  Bit Score: 75.91  E-value: 7.33e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574 439 QLDDGSGRTYQLREGSNIIGRGQDAQFRLPDTGVSRRHLEIRWDGQVALLADLNSTNGTTVNNAPVQEWQLADGDVIRLG 518
Cdd:cd22698    7 QKGSEEGKDYELDQDEFTIGRSSNNDIRLNDHSVSRHHARIVRQGDKCNLTDLGSTNGTFLNGIRVGTHELKHGDRIQLG 86

                 ....*..
gi 490009574 519 hsEIIVR 525
Cdd:cd22698   87 --ETIFR 91
FHA pfam00498
FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.
456-517 1.09e-16

FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.


Pssm-ID: 459831 [Multi-domain]  Cd Length: 66  Bit Score: 74.53  E-value: 1.09e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490009574  456 IIGRGQDAQFRLPDTGVSRRHLEIRWDGQVAL-LADLNSTNGTTVNNAPVQE--WQLADGDVIRL 517
Cdd:pfam00498   2 TIGRSPDCDIVLDDPSVSRRHAEIRYDGGGRFyLEDLGSTNGTFVNGQRLGPepVRLKDGDVIRL 66
FHA_Rv1747-like_rpt1 cd22694
first forkhead associated (FHA) domain found in Mycobacterium tuberculosis ABC transporter ...
445-520 1.35e-14

first forkhead associated (FHA) domain found in Mycobacterium tuberculosis ABC transporter ATP-binding/permease protein Rv1747 and similar proteins; Rv1747 is a putative ATP-binding cassette (ABC) transporter involved in the translocation of an unknown substrate across the membrane. It is required for normal virulent infection by M. tuberculosis. Rv1747 has a cytoplasmic regulatory module consisting of two pThr-interacting forkhead-associated (FHA) domains connected by a conformationally disordered linker with two phospho-acceptor threonines (pThr). Recruitment and phosphorylation of Rv1747 depend on the interaction between its two non-redundant FHA domains and the autophosphorylated form of serine/threonine protein kinase PknF. This model corresponds to the first FHA domain. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438746 [Multi-domain]  Cd Length: 93  Bit Score: 69.28  E-value: 1.35e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490009574 445 GRTYQLREGSNI-IGRGQDAQFRLPDTGVSRRHLEIRWDGQVALLADLNSTNGTTVNNAPVQEWQLADGDVIRLGHS 520
Cdd:cd22694    7 GGELRFDPGSSVrIGRDPDADVRLDDPRVSRRHALLEFDGDGWVYTDLGSRNGTYLNGRRVQQVKLSDGTRVRLGDP 83
FHA_Ki67 cd22673
forkhead associated (FHA) domain found in proliferation marker protein Ki-67 and similar ...
436-518 2.12e-14

forkhead associated (FHA) domain found in proliferation marker protein Ki-67 and similar proteins; Ki-67, also called antigen identified by monoclonal antibody Ki-67, antigen KI-67, or antigen Ki67, acts as a biological surfactant to disperse mitotic chromosomes. It is required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly. Ki-67 binds DNA with a preference for supercoiled DNA and AT-rich DNA. It may also play a role in chromatin organization. Ki-67 contains an FHA domain at its N-terminus. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438725 [Multi-domain]  Cd Length: 95  Bit Score: 68.78  E-value: 2.12e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574 436 VTLQLDDGSGRTYQLREGSNIIGRGQDAQFRLPDTGVSRRHLEIRWDGQV-ALLADLNSTNGTTVNNAPVQE-WQLADGD 513
Cdd:cd22673    4 VVIKKDGTDGSRFPLTKKSCTFGRDLSCDIRIQLPGVSREHCRIEVDENGkAYLENLSTTNPTLVNGKAIEKsAELKDGD 83

                 ....*
gi 490009574 514 VIRLG 518
Cdd:cd22673   84 VITIG 88
FHA_MDC1 cd22665
forkhead associated (FHA) domain found in mediator of DNA damage checkpoint protein 1 (MDC1) ...
442-518 2.46e-14

forkhead associated (FHA) domain found in mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins; MDC1, also called nuclear factor with BRCT domains 1 (NFBD1), is a nuclear chromatin-associated protein that is required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S and G2/M phases of the cell cycle. It directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. MDC1 contains a forkhead-associated (FHA) domain and two BRCT domains, as well as an internal 41-amino acid repeat sequence. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438717 [Multi-domain]  Cd Length: 97  Bit Score: 68.80  E-value: 2.46e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574 442 DGSGRTYQLREGSNIIGRGQDAQFRLPDTGVSRRHLEIRWDGQVALLADLNSTNGTTVNN----APVQEWQLADGDVIRL 517
Cdd:cd22665   10 HGPEKDFPLYEGENVIGRDPSCSVVLPDKSVSKQHACIEVDGGTHLIEDLGSTNGTRIGNkvrlKPNVRYELIDGDLLLF 89

                 .
gi 490009574 518 G 518
Cdd:cd22665   90 G 90
COG3456 COG3456
Predicted component of the type VI protein secretion system, contains a FHA domain [Signal ...
439-526 5.85e-13

Predicted component of the type VI protein secretion system, contains a FHA domain [Signal transduction mechanisms, Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442679 [Multi-domain]  Cd Length: 402  Bit Score: 70.56  E-value: 5.85e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574 439 QLDDGSGRTYQLREGSNIIGRGQDAQFRLPDTG--VSRRHLEIRWDGQVALLADLnSTNGTTVNNAPV-----QEWQLAD 511
Cdd:COG3456   12 DLESGSAASATFGRGGGTIGRSADCDWVLPDPDrsVSRRHAEIRFRDGAFCLTDL-STNGTFLNGSDHplgpgRPVRLRD 90
                         90
                 ....*....|....*
gi 490009574 512 GDVIRLGHSEIIVRM 526
Cdd:COG3456   91 GDRLRIGDYEIRVEI 105
FHA_DgcB-like cd22682
forkhead associated (FHA) domain found in Bdellovibrio bacteriovorus GGDEF domain protein DgcB ...
443-518 5.87e-12

forkhead associated (FHA) domain found in Bdellovibrio bacteriovorus GGDEF domain protein DgcB and similar proteins; DgcB is a GGDEF enzyme that produces cyclic-di-GMP in response to an unknown stimulus. It appends the C-terminal GGDEF enzymatic domain with an N-terminal forkhead-associated (FHA) domain that acts as a consensus phosphopeptide sensor. The GGDEF and sensory FHA domains form an asymmetrical dimer.


Pssm-ID: 438734 [Multi-domain]  Cd Length: 96  Bit Score: 61.77  E-value: 5.87e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490009574 443 GSGRTYQLREGSNIIGRGQDAQFRLPDTGVSRRHLEIRWDGQVALLADLNSTNGTTVNN---APVQEWQLADGDVIRLG 518
Cdd:cd22682   10 GVGKQFPITESTIVIGRSVESQVQIDDDSVSRYHAKLAVNPSAVSIIDLGSTNGTIVNGkkiPKLASCDLQNGDQIKIG 88
FHA smart00240
Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear ...
456-504 1.14e-11

Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain.


Pssm-ID: 214578 [Multi-domain]  Cd Length: 52  Bit Score: 59.50  E-value: 1.14e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 490009574   456 IIGRG-QDAQFRLPDTGVSRRHLEIRWDGQ-VALLADLNSTNGTTVNNAPV 504
Cdd:smart00240   2 TIGRSsEDCDIQLDGPSISRRHAVIVYDGGgRFYLIDLGSTNGTFVNGKRI 52
FHA_PP2C70-like cd22678
forkhead associated (FHA) domain found in Arabidopsis thaliana protein phosphatase 2C 70 ...
444-523 5.14e-11

forkhead associated (FHA) domain found in Arabidopsis thaliana protein phosphatase 2C 70 (AtPP2C70) and similar proteins; AtPP2C70, also called kinase-associated protein phosphatase, or protein ROOT ATTENUATED GROWTH 1, dephosphorylates the serine/threonine receptor-like kinase RLK5. It may function as a signaling component in a pathway involving RLK5. It acts as a negative regulator of the CLAVATA1 signaling in plant development by binding and dephosphorylating CLAVATA1. It is also a component of a signaling pathway which mediates adaptation to NaCl stress. It contains an FHA domain, which is a small phosphopeptide recognition module.


Pssm-ID: 438730 [Multi-domain]  Cd Length: 102  Bit Score: 59.30  E-value: 5.14e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574 444 SGRTYQLREGSN---IIGRGQDAQFRLPDTGVSRRHLEIRWDGQVA--LLADLNSTNGTTVNNAPVQ----EWQLADGDV 514
Cdd:cd22678   11 EGLRFDLQPGTRlplTIGRIQRGDIALKDDEVSGKHARIEWNSTGSkwELVDLGSLNGTLVNGESISpngrPVVLSSGDV 90

                 ....*....
gi 490009574 515 IRLGHSEII 523
Cdd:cd22678   91 ITLGSETKI 99
FHA_FhaB-like cd22693
forkhead associated (FHA) domain found in Mycobacterium tuberculosis FHA domain-containing ...
445-525 8.54e-11

forkhead associated (FHA) domain found in Mycobacterium tuberculosis FHA domain-containing protein FhaB and similar proteins; FhaB, also called FtsZ-interacting protein A (FipA), is a putative virulence factor involved in regulating cell shape. It can interact with polyketide-associated protein PapA5, a putative membrane protein involved in the biosynthesis of virulence enhancing lipids. FhaB regulates growth and cell division. It is probably required for divisomal protein assembly under oxidative stress. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438745 [Multi-domain]  Cd Length: 91  Bit Score: 58.47  E-value: 8.54e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574 445 GRTYQLREGSNIIGRGQDAQFRLPDTGVSRRHLEIRWDGQVALLADLNSTNGTTVNNAPV-QEWQLADGDVIRLGHSEII 523
Cdd:cd22693   10 GQTFPIDKSGITIGRADDNDLVLSDDFVSSRHARIYLQGSSWYLEDLGSTNGTFVNGNRVtQPVVVQPGDTIRIGATVFE 89

                 ..
gi 490009574 524 VR 525
Cdd:cd22693   90 VR 91
VI_FHA TIGR03354
type VI secretion system FHA domain protein; Members of this protein family are FHA ...
439-527 2.50e-10

type VI secretion system FHA domain protein; Members of this protein family are FHA (forkhead-associated) domain-containing proteins that are part of type VI secretion loci in a considerable number of bacteria, most of which are known pathogens. Species include Pseudomonas aeruginosa PAO1, Aeromonas hydrophila, Yersinia pestis, Burkholderia mallei, etc. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 274537 [Multi-domain]  Cd Length: 396  Bit Score: 62.39  E-value: 2.50e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574  439 QLDDGSGRTYQLREGSNIIGRGQDAQFRLPDTG--VSRRHLEIRWDGQVALLADLnSTNGTTVNNAPVQ-----EWQLAD 511
Cdd:TIGR03354  10 QLTPGIAAQKTFGTNGGTIGRSEDCDWVLPDPErhVSGRHARIRYRDGAYLLTDL-STNGVFLNGSGSPlgrgnPVRLEQ 88
                          90
                  ....*....|....*.
gi 490009574  512 GDVIRLGHSEIIVRMH 527
Cdd:TIGR03354  89 GDRLRLGDYEIRVSLG 104
Yop-YscD_cpl pfam16697
Inner membrane component of T3SS, cytoplasmic domain; Yop-YscD-cpl is the cytoplasmic domain ...
444-518 3.91e-10

Inner membrane component of T3SS, cytoplasmic domain; Yop-YscD-cpl is the cytoplasmic domain of Yop proteins like YscD from Proteobacteria. YscD forms part of the inner membrane component of the bacterial type III secretion injectosome apparatus.


Pssm-ID: 465238 [Multi-domain]  Cd Length: 94  Bit Score: 56.50  E-value: 3.91e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490009574  444 SGRTYQLREGSNIIGRGQDAQFRLPDTGVSRRHLEIRWDGQVALLADLNSTNGTTVNNAPV--QEWQLADGDVIRLG 518
Cdd:pfam16697   8 AGAEFPLEGGRYRIGSDPDCDIVLSDKEVSRVHLKLEVDDEGWRLDDLGSGNGTLVNGQRVteLGIALRPGDRIELG 84
FHA_ArnA-like cd22680
forkhead associated (FHA) domain found in Sulfolobus Acidocaldarius FHA domain-containing ...
436-523 1.03e-09

forkhead associated (FHA) domain found in Sulfolobus Acidocaldarius FHA domain-containing protein ArnA and similar proteins; ArnA is an FHA domain-containing protein from Sulfolobus acidocaldarius that was shown to strongly interact with ArnB, a von Willebrand domain-containing protein. They act synergistically and negatively to modulate motility. ArnA is involved in regulating archaella expression in S. acidocaldarius. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438732 [Multi-domain]  Cd Length: 96  Bit Score: 55.42  E-value: 1.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574 436 VTLQLDDGSGRTYQLREGSNIIGRGQDAQFRLPDTGVSRRHLEIRWDGQVALLADLNSTNGTTVNN-APVQ-EWQLADGD 513
Cdd:cd22680    4 EILSSPNLTGKKFPFDFSSVSIGRDPENVIVIPDPFVSRNHARITVDSNEIYIEDLGSTNGTFVNDfKRIKgPAKLHPND 83
                         90
                 ....*....|
gi 490009574 514 VIRLGHSEII 523
Cdd:cd22680   84 IIKLGRTTVL 93
FHA_Rv1747-like_rpt2 cd22737
second forkhead associated (FHA) domain found in Mycobacterium tuberculosis ABC transporter ...
442-522 3.97e-09

second forkhead associated (FHA) domain found in Mycobacterium tuberculosis ABC transporter ATP-binding/permease protein Rv1747 and similar proteins; Rv1747 is a putative ATP-binding cassette (ABC) transporter involved in the translocation of an unknown substrate across the membrane. It is required for normal virulent infection by M. tuberculosis. Rv1747 has a cytoplasmic regulatory module consisting of two pThr-interacting forkhead-associated (FHA) domains connected by a conformationally disordered linker with two phospho-acceptor threonines (pThr). Recruitment and phosphorylation of Rv1747 depend on the interaction between its two non-redundant FHA domains and the autophosphorylated form of serine/threonine protein kinase PknF. This model corresponds to the second FHA domain, which has a circularly permuted FHA domain fold with a conserved pThr-binding interface.


Pssm-ID: 439356 [Multi-domain]  Cd Length: 93  Bit Score: 53.65  E-value: 3.97e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574 442 DGSGRTYQLREGSNIIGRGQDAQFRLPDTGVSRRHLEIRWDGQVALLADLNSTNGTTVNNAPVQEWQLADGDVIRLGHSE 521
Cdd:cd22737   10 DGDTLTFELPPQAVRIGRASDNDIVIPEGSVSRHHATLVPTPGGTQIRDLRSTNGTFVNGLRVDAALLHDGDVVTIGDID 89

                 .
gi 490009574 522 I 522
Cdd:cd22737   90 F 90
FHA_APTX-like cd22671
forkhead associated (FHA) domain found in aprataxin, bifunctional polynucleotide phosphatase ...
440-523 5.66e-09

forkhead associated (FHA) domain found in aprataxin, bifunctional polynucleotide phosphatase/kinase (PNKP), aprataxin and PNK-like factor (APLF), and similar proteins; The family includes aprataxin, PNKP, and APLF. Aprataxin (EC 3.6.1.71/EC 3.6.1.72), also called forkhead-associated domain histidine triad-like protein (FHA-HIT), is a DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair, and base excision repair. It catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. It can also hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity. Likewise, it catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA but has higher specific activity with 5'-linked adenosine (AppDNA). PNKP (EC 3.1.3.32/EC 2.7.1.78), also called DNA 5'-kinase/3'-phosphatase, or polynucleotide kinase-3'-phosphatase, plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNKP ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone. APLF, also called apurinic-apyrimidinic endonuclease APLF, PNK and APTX-like FHA domain-containing protein, or XRCC1-interacting protein 1 (XIP1), is a novel apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease with conserved zinc-finger-like motifs involved in single-strand and double-strand DNA break repair. It is recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. It can introduce nicks at hydroxyuracil and other types of pyrimidine base damage. Together with PARP3, APLF promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ). Members of this family contain an FHA domain at their N-terminus. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438723 [Multi-domain]  Cd Length: 101  Bit Score: 53.47  E-value: 5.66e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574 440 LDDGSGRTYQLRE-GSNIIGRGQdaQFRLPDTGVSRRHLEIRWDGQV-ALLADLNSTNGTTVNNAPVQEWQLADGDVIRL 517
Cdd:cd22671    5 VDGGGGPPIELKEgGPTVLGRGP--LLGIRDKRVSRKQAEITVDDDTgSVTVTQLGTNPSFVNRADGEGKVLKKGESVEL 82

                 ....*.
gi 490009574 518 GHSEII 523
Cdd:cd22671   83 KDGDVI 88
FHA_MEK1-like cd22670
forkhead associated (FHA) domain found in Saccharomyces cerevisiae meiosis-specific serine ...
450-527 7.88e-09

forkhead associated (FHA) domain found in Saccharomyces cerevisiae meiosis-specific serine/threonine-protein kinase MEK1 and similar proteins; MEK1 (EC 2.7.11.1), also known as MRE4, is a meiosis-specific protein kinase required for chromosome synapsis and meiotic recombination. The recruitment and activation of MEK1 require the phosphorylation of the chromosome axis protein Hop1 at Thr318 (pT318), which is necessary for recognition by the MEK1 FHA domain. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438722 [Multi-domain]  Cd Length: 105  Bit Score: 53.39  E-value: 7.88e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574 450 LREGSNI-IGRGQDAQFRLPDTGVSRRHLEI---RWDGQVALLA---DLnSTNGTTVNNAPVQEWQ---LADGDVIRLGH 519
Cdd:cd22670   18 IYKNQVItIGRSPSCDIVINDPFVSRTHCRIysvQFDESSAPLVyveDL-SSNGTYLNGKLIGRNNtvlLSDGDVIEIAH 96

                 ....*...
gi 490009574 520 SEIIVRMH 527
Cdd:cd22670   97 SATFVYVH 104
FHA_Ct664-like cd22696
forkhead associated (FHA) domain found in Chlamydia trachomatis Ct664 protein and similar ...
444-524 3.43e-08

forkhead associated (FHA) domain found in Chlamydia trachomatis Ct664 protein and similar proteins; This subfamily corresponds to a group of uncharacterized FHA domain-containing proteins which show high sequence similarity with Chlamydia trachomatis Ct664 protein. Ct664 situates within the type III secretion system cluster that also encodes an STPK (CT673 in C. trachomatis), suggesting a role of CT664 in the chlamydial type III secretion system by mediating phosphorylation-dependent protein-protein interactions. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438748 [Multi-domain]  Cd Length: 97  Bit Score: 51.34  E-value: 3.43e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574 444 SGRTYqlregsnIIGR-GQDAQFRLPDTGVSRRH--LEIRWDGQVaLLADLNSTNGTTVNNAPVQEWQLADG-DVIRLGH 519
Cdd:cd22696   19 SGKTY-------FIGKdPTVCDIVLQDPSISRQHarLSIDQDNRV-FIEDLSSKNGVLVNGKPIEGKEEISGsDVISLGT 90

                 ....*
gi 490009574 520 SEIIV 524
Cdd:cd22696   91 TSFLL 95
FHA_GarA_OdhI-like cd22684
forkhead associated (FHA) domain found in Mycobacterium tuberculosis GarA, Corynebacterium ...
458-518 6.00e-08

forkhead associated (FHA) domain found in Mycobacterium tuberculosis GarA, Corynebacterium glutamicum OdhI and similar proteins; This family includes Mycobacterium tuberculosis glycogen accumulation regulator GarA and Corynebacterium glutamicum oxoglutarate dehydrogenase inhibitor (OdhI). GarA is involved in the regulation of glutamate metabolism. It acts as a phosphorylation-dependent molecular switch that modulates the activities of Kgd, Gdh and GltB. GarA binds to Kgd, Gdh, GltB, PknB, and the N-terminal region of PknG via its FHA domain. OdhI is an essential component of the PknG signaling pathway. It can inhibit the activity of 2-oxoglutarate dehydrogenase only when it is unphosphorylated. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438736 [Multi-domain]  Cd Length: 94  Bit Score: 50.46  E-value: 6.00e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490009574 458 GRGQDAQFRLPDTGVSRRHLEIRWDGQVALLADLNSTNGTTVNNAPVQEWQLADGDVIRLG 518
Cdd:cd22684   26 GRHPESDIFLDDVTVSRRHAEFRRAEGGFVVRDVGSLNGTYVNRERIDSAVLRNGDEVQIG 86
FHA_GarA-like cd22720
forkhead associated (FHA) domain found in Mycobacterium tuberculosis glycogen accumulation ...
444-523 7.34e-08

forkhead associated (FHA) domain found in Mycobacterium tuberculosis glycogen accumulation regulator GarA and similar proteins; GarA is an FHA domain-containing protein involved in the regulation of glutamate metabolism. It acts as a phosphorylation-dependent ON/OFF molecular switch that modulates the activities of KGD, GDH and GltB. Its FHA domain has dual specificity. It binds to both phosphorylated upstream partners, such as the kinases PknB and PknG, and nonphosphorylated downstream partners, such as the 2-oxoglutarate decarboxylase KGD. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438772 [Multi-domain]  Cd Length: 100  Bit Score: 50.39  E-value: 7.34e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574 444 SGRTYQLREGSNIIGRGQDAQFRLPDTGVSRRHLEIRWDGQVALLADLNSTNGTTVNNAPVQEWQLADGDVIRLGHSEII 523
Cdd:cd22720   15 AGSRFLLDQAITSAGRHPDSDIFLDDVTVSRRHAEFRLENNEFNVVDVGSLNGTYVNREPVDSAVLANGDEVQIGKFRLV 94
FHA_NBN cd22667
forkhead associated (FHA) domain found in nibrin and similar proteins; Nibrin (NBN), also ...
441-525 1.14e-07

forkhead associated (FHA) domain found in nibrin and similar proteins; Nibrin (NBN), also called cell cycle regulatory protein p95, or Nijmegen breakage syndrome protein 1 (NBS1), is a novel DNA double-strand break repair protein that is mutated in Nijmegen breakage syndrome. It is a component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. Nibrin modulates the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-dependent protein kinase catalytic subunit (DNA-PKcs) to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. Nibrin also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. Nibrin is a major player in the control of intra-S-phase checkpoint. This subfamily also includes Schizosaccharomyces pombe DNA repair and telomere maintenance protein Nbs1 and Arabidopsis thaliana AtNbs1. SpNbs1 is an FHA domain-containing protein required for DNA damage repair and S-phase DNA damage checkpoint. It is involved in telomere length maintenance and maintenance of chromatin structure. AtNbs1 is a component of MRN complex. It also functions in the very early stages of meiosis. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438719 [Multi-domain]  Cd Length: 108  Bit Score: 50.02  E-value: 1.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574 441 DDGSGRTYQLREG-SNIIGRGQDAQFRLPDTGVSRRHLEIRWDGQVALLADLN----------STNGTTVNNAPVQEWQ- 508
Cdd:cd22667    7 QDGAGTSYYLLPGgEYTVGRKDCDIIIVDDSSISRKHATLTVLHPEANLSDPDtrpeltlkdlSKYGTFVNGEKLKGGSe 86
                         90
                 ....*....|....*....
gi 490009574 509 --LADGDVIRLGHSEIIVR 525
Cdd:cd22667   87 vtLKDGDVITFGVLGSKFR 105
FHA_Cep170 cd22704
forkhead associated (FHA) domain found in the centrosomal protein of 170 kDa protein (Cep170) ...
440-525 1.20e-07

forkhead associated (FHA) domain found in the centrosomal protein of 170 kDa protein (Cep170) family; The Cep170 family includes Cep170 and Cep170B. Cep170, also called Cep170A, KARP-1-binding protein, or KARP1-binding protein, is a protein that localizes to centrosomes as well as spindle microtubules and plays a role in microtubule organization and microtubule assembly. It is required for centriole subdistal appendage assembly. Cep170 is phosphorylated during M phase and interacts with Polo-like kinase 1 (Plk1). Cep170B, also called centrosomal protein 170B, plays a role in microtubule organization. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438756 [Multi-domain]  Cd Length: 102  Bit Score: 50.01  E-value: 1.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574 440 LDDGSGRTYQLREGSNIIGRgQDAQFRLPDTGVSRRHLEIRWDGQVAL--LADLNSTNGTTVNNAPVQEW---QLADGDV 514
Cdd:cd22704    4 LVSSDGTRHRLPRSMLFVGR-EDCDLILQSRSVDKQHAVITYDQIDNEfkIKDLGSLNGTFVNDSRIPEQtyiTLKLGDS 82
                         90
                 ....*....|.
gi 490009574 515 IRLGHSEIIVR 525
Cdd:cd22704   83 IRFGYDTNVYR 93
FHA_PS1-like cd22691
forkhead associated (FHA) domain found in Arabidopsis thaliana Protein PARALLEL SPINDLE 1 (PS1) ...
456-527 5.09e-07

forkhead associated (FHA) domain found in Arabidopsis thaliana Protein PARALLEL SPINDLE 1 (PS1) and similar proteins; PS1 is an FHA domain-containing protein required for normal spindle orientation at male meiosis II and normal formation of tetrad of microspores. It is not involved in female meiosis. Mutations in PS1 lead to the production of diploid pollen grains. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438743 [Multi-domain]  Cd Length: 113  Bit Score: 48.18  E-value: 5.09e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490009574 456 IIGRGQDAQFRLPDTGVSRRHLEIRWDG--QVALLADLNSTNGTTVNN---APVQEWQLADGDVIRLGHSEIIVRMH 527
Cdd:cd22691   32 VVGRHPDCDIVLDHPSISRFHLEIRIIPsrRKITLTDLSSVHGTWVNGqriEPGVPVELEEGDTVRLGASTRVYRLH 108
FHA_Slr1951-like cd22697
forkhead associated (FHA) domain found in Synechocystis sp. Slr1951 protein and similar ...
436-527 6.41e-07

forkhead associated (FHA) domain found in Synechocystis sp. Slr1951 protein and similar proteins; This subfamily corresponds to a group of uncharacterized FHA domain-containing proteins which show high sequence similarity with Synechocystis sp. protein Slr1951 and protein Sll1895. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438749 [Multi-domain]  Cd Length: 102  Bit Score: 47.84  E-value: 6.41e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574 436 VTLQLDDGSGRTYQLREGSNIIGRGQDAQFRLPDTGVSRRHLEIRWDGQVALLADL----------NSTNGTTVNNAPVQ 505
Cdd:cd22697    1 ILVELDGNVRREIRLDEPIYTIGRHPGNDIQIPSQQISRRHATLRRKINPNLDISFwiidgdlegaESLNGLWVNGERIL 80
                         90       100
                 ....*....|....*....|..
gi 490009574 506 EWQLADGDVIRLGHSeIIVRMH 527
Cdd:cd22697   81 QHELVNGDEIALGPK-IVLRYQ 101
dnaA PRK14086
chromosomal replication initiator protein DnaA;
178-377 1.29e-06

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 50.98  E-value: 1.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574 178 RYARPQEDPRGGPDPQGGSDPRGGYPpetgGYPPQPGYPRPRHPDQGD-YPE-QIGYPDQGGYPEQRGYPeqrGYPDQRG 255
Cdd:PRK14086  94 EPAPPPPHARRTSEPELPRPGRRPYE----GYGGPRADDRPPGLPRQDqLPTaRPAYPAYQQRPEPGAWP---RAADDYG 166
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574 256 YQdqgrgypdQGQGGYPPPYEQRPPVSPGPAAGYGAPGYDQGYRQSGGYGPSPGGGQPGYGGYGEYGRGPARHEEGS-YV 334
Cdd:PRK14086 167 WQ--------QQRLGFPPRAPYASPASYAPEQERDREPYDAGRPEYDQRRRDYDHPRPDWDRPRRDRTDRPEPPPGAgHV 238
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 490009574 335 PSGPPGPPE-----QRPAYPDQGGYDQGYQQGATTYGRQDYGGGADYT 377
Cdd:PRK14086 239 HRGGPGPPErddapVVPIRPSAPGPLAAQPAPAPGPGEPTARLNPKYT 286
FHA_FHAD1 cd22700
forkhead associated (FHA) domain found in forkhead-associated domain-containing protein 1 ...
443-520 1.53e-06

forkhead associated (FHA) domain found in forkhead-associated domain-containing protein 1 (FHAD1) and similar proteins; FHAD1, also called FHA domain-containing protein 1, is an uncharacterized FHA domain-containing protein. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438752 [Multi-domain]  Cd Length: 96  Bit Score: 46.48  E-value: 1.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574 443 GSGRTYQLREGSNIIGRGqDAQFRLPDTGVSRRHLEIRWDGQVA--LLADLNSTNGTTVNNAPVQEW--QLADGDVIRLG 518
Cdd:cd22700    6 SSDGIFQLDPKVTTIGRE-GCDLVLQSPGVEEQHAVIEYSEQENcfVLQDLNTAQGTYVNDCRIQNAavRLAPGDVLRFG 84

                 ..
gi 490009574 519 HS 520
Cdd:cd22700   85 FG 86
FHA_OdhI-like cd22721
forkhead associated (FHA) domain found in Corynebacterium glutamicum oxoglutarate ...
444-523 2.59e-06

forkhead associated (FHA) domain found in Corynebacterium glutamicum oxoglutarate dehydrogenase inhibitor (OdhI) and similar proteins; OdhI is an essential component of the PknG signaling pathway. It regulates glutamate production under biotin non-limiting conditions. It can inhibit the activity of 2-oxoglutarate dehydrogenase only when it is unphosphorylated. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438773 [Multi-domain]  Cd Length: 102  Bit Score: 46.23  E-value: 2.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574 444 SGRTYQLREGSNIIGRGQDAQFRLPDTGVSRRHLEIRWDGQVALLADLNSTNGTTVNNAPVQEWQLADGDVIRLGHSEII 523
Cdd:cd22721   20 AGARFLLDQPTTTAGRHPESDIFLDDVTVSRRHAEFRINEGEFEVVDVGSLNGTYVNREPRNAQVMQTGDEIQIGKFRLV 99
FHA_AGGF1 cd22686
forkhead associated (FHA) domain found in angiogenic factor with G patch and FHA domains 1 ...
446-527 3.72e-06

forkhead associated (FHA) domain found in angiogenic factor with G patch and FHA domains 1 (AGGF1) and similar proteins; AGGF1, also called angiogenic factor VG5Q, or G patch domain-containing protein 7 (GPATC7), or vasculogenesis gene on 5q protein, is an angiogenic factor involved in vascular development, angiogenesis, specification of hemangioblasts, and differentiation of veins. It promotes angiogenesis and the proliferation of endothelial cells. It inhibits inflammatory effect and preserve vascular integrity in non-nervous system diseases. Mutated AGGF1 causes susceptibility to Klippel-Trenaunay syndrome, a vascular disorder. Increased AGGF1 expression is associated with tumor angiogenesis. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438738 [Multi-domain]  Cd Length: 123  Bit Score: 46.12  E-value: 3.72e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574 446 RTYQLREGS--------NIIGRGQDAQF--RLPDTGVSRRHLEIRWD--GQVALLADLNSTNGTTVNNAPV-------QE 506
Cdd:cd22686   11 ESPSLQVGSlfivtatgATIGREKDHGHtiRIPELGVSKFHAEIYYDddEQSYTIVDLGSQNGTYLNGVRIsqpkeksDP 90
                         90       100
                 ....*....|....*....|.
gi 490009574 507 WQLADGDVIRLGHSEIIVRMH 527
Cdd:cd22686   91 YPLTHGDELKIGETTLLFHIH 111
FHA_SNIP1_DDL-like cd22676
forkhead associated (FHA) domain found in Smad nuclear-interacting protein 1 (SNIP1), FHA ...
490-521 9.19e-06

forkhead associated (FHA) domain found in Smad nuclear-interacting protein 1 (SNIP1), FHA domain-containing protein DDL, and similar proteins; SNIP1 is an FHA domain-containing protein required for pre-mRNA splicing as a component of the spliceosome. It inhibits NF-kappaB signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators. It is involved in microRNA (miRNA) biogenesis. SNIP1 is a regulator of the cell cycle and cyclin D1 expression and may be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. This family also includes Arabidopsis thaliana FHA domain-containing protein DDL and similar proteins. DDL, also called protein DAWDLE, is involved in the microRNA (miRNA) and short interfering RNA (siRNA) biogenesis. It may facilitate DCL1 to access or recognize primary miRNAs. DDL binds RNA non-specifically. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438728 [Multi-domain]  Cd Length: 111  Bit Score: 44.60  E-value: 9.19e-06
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 490009574 490 DLNSTNGTTVNNAPVQEW---QLADGDVIRLGHSE 521
Cdd:cd22676   71 DLGSTNGTFLNGEKIEPRryyELREKDVLKFGLST 105
FHA_EmbR-like cd22669
forkhead associated (FHA) domain found in Mycobacterium tuberculosis transcriptional ...
444-518 9.22e-06

forkhead associated (FHA) domain found in Mycobacterium tuberculosis transcriptional regulatory protein EmbR and similar proteins; EmbR is a transcriptional regulator of the embCAB operon encoding cell wall arabinosyltransferases (EmbC, -A, and -B), and is phosphorylated by the cognate mycobacterial serine/threonine protein kinase PknH. It interacts with RNA polymerase and possesses a phosphorylation-dependent ATPase activity. EmbR contains a regulatory C-terminal forkhead-associated (FHA) domain, which mediates binding to a threonine-phosphorylated site in PknH. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438721 [Multi-domain]  Cd Length: 89  Bit Score: 44.33  E-value: 9.22e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490009574 444 SGRTYQLREGSNIIGRGQDAQFRLPDTGVSRRHLEIRWDGQVALLADLNSTNGTTVNNAPVQEWQ-LADGDVIRLG 518
Cdd:cd22669    7 SGRGYPLQAAATRIGRLHDNDIVLDSANVSRHHAVIVDTGTNYVINDLRSSNGVHVQHERIRSAVtLNDGDHIRIC 82
FHA_CHFR cd22672
forkhead associated (FHA) domain found in checkpoint with forkhead and RING finger domains ...
440-519 1.35e-05

forkhead associated (FHA) domain found in checkpoint with forkhead and RING finger domains protein (CHFR); CHFR, also called RING finger protein 196 (RNF196), is a checkpoint protein that delays entry into mitosis in response to stress. It functions as an E3 ubiquitin ligase that ubiquitinates and degrades its target proteins, such as Aurora-A, Plk1, Kif22 and PARP-1, which are critical for proper mitotic transitions. It also plays an important role in cell cycle progression and tumor suppression and is negatively regulated by SUMOylation-mediated proteasomal ubiquitylation. Moreover, CHFR is involved in the early stage of the DNA damage response, which mediates the crosstalk between ubiquitination and poly-ADP-ribosylation. CHFR contains a fork head associated-(FHA) domain and a RING-HC finger. The CHFR FHA domain has been crystallized as a segment-swapped dimer. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438724 [Multi-domain]  Cd Length: 108  Bit Score: 44.21  E-value: 1.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574 440 LDDGSGRTYQLREGSNIIGRGQDAQFRLPDTG-VSRRHLEIRWD--GQVALlADlNSTNGTTVNNAPV---QEWQLADGD 513
Cdd:cd22672    8 LTEESSPPILLRKDEFTIGRAKDCDLSFPGNKlVSGDHCKIIRDekGQVWL-ED-TSTNGTLVNKVKVvkgQKVELKHGD 85

                 ....*.
gi 490009574 514 VIRLGH 519
Cdd:cd22672   86 VIYLVY 91
FHA_PML1-like cd22681
forkhead associated (FHA) domain found in Saccharomyces cerevisiae pre-mRNA leakage protein 1 ...
441-517 1.71e-04

forkhead associated (FHA) domain found in Saccharomyces cerevisiae pre-mRNA leakage protein 1 (PML1) and similar proteins; PML1 is an FHA domain-containing protein required for efficient splicing and pre-mRNA nuclear retention. It is a component of the pre-mRNA retention and splicing (RES) complex composed of at least BUD13, IST3, and PML1. It contains an FHA domain, which is a small phosphopeptide recognition module.


Pssm-ID: 438733 [Multi-domain]  Cd Length: 129  Bit Score: 41.66  E-value: 1.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574 441 DDGSGRTYQLREGSN-IIGRGQD-------AQFRLPDTGVSRRHLEIRW---DGQ-VALLADLNSTNGTTVNNAPV---Q 505
Cdd:cd22681   27 SKGPIEEYELNSPSCyLIGREKGesteivvADIGIPEETCSKQHCVIQFrnvKGIlKPYIMDLDSSNGTCLNDNVIpssR 106
                         90
                 ....*....|..
gi 490009574 506 EWQLADGDVIRL 517
Cdd:cd22681  107 YVELRSGDVITF 118
dnaA PRK14086
chromosomal replication initiator protein DnaA;
118-294 1.83e-04

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 44.05  E-value: 1.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574 118 QFRARGTVNPDVETHPPVIDCAR----PQSNHafGAEPGVAPMSDNSSYRGGQGQGRPDEYYDDRYARPQEDPRGGPDPQ 193
Cdd:PRK14086  81 PIRIAITVDPSAGEPAPPPPHARrtsePELPR--PGRRPYEGYGGPRADDRPPGLPRQDQLPTARPAYPAYQQRPEPGAW 158
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574 194 GGSDPRGGYPPETGGYPPQPGYPRP----RHPDQGDYPEQIGYPDQGgyPEQRGYPEQRGYPDQRGYQDQGRGYPDQGQG 269
Cdd:PRK14086 159 PRAADDYGWQQQRLGFPPRAPYASPasyaPEQERDREPYDAGRPEYD--QRRRDYDHPRPDWDRPRRDRTDRPEPPPGAG 236
                        170       180
                 ....*....|....*....|....*....
gi 490009574 270 ----GYPPPYEqrPPVSPGPAAGYGAPGY 294
Cdd:PRK14086 237 hvhrGGPGPPE--RDDAPVVPIRPSAPGP 263
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
121-292 2.25e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 44.21  E-value: 2.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574 121 ARGTVNPDVETHPPVIDCARPQSNHAFGAEPGVAPMSDNSSYRGGQGQGRPDEYYDDRYARPQEDPRGGPDPQGGSDPRG 200
Cdd:PRK07764 595 AGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAG 674
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574 201 GYPPETGGYPPQPGYPRPRHPDQGdypeqiGYPDQGGYPEQRGYPEQRGYPDQRGYQDQGRGYPDQGQGGYPPPYEQRPP 280
Cdd:PRK07764 675 GAAPAAPPPAPAPAAPAAPAGAAP------AQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDP 748
                        170
                 ....*....|..
gi 490009574 281 VSPGPAAGYGAP 292
Cdd:PRK07764 749 PDPAGAPAQPPP 760
FHA_TCF19 cd22685
forkhead associated (FHA) domain found in transcription factor 19 (TCF-19) and similar ...
470-520 5.40e-04

forkhead associated (FHA) domain found in transcription factor 19 (TCF-19) and similar proteins; TCF-19, also called transcription factor SC1, was identified as a putative trans-activating factor with expression beginning at the late G1-S boundary in dividing cells. It also functions as a novel islet factor necessary for proliferation and survival in the INS-1 beta cell line. It plays an important role in susceptibility to both Type 1 Diabetes Mellitus (T1DM) and Type 2 Diabetes Mellitus (T2DM); it has been suggested that it may positively impact beta cell mass under conditions of beta cell stress and increased insulin demand. TCF-19 contains an N-terminal fork head association domain (FHA), a proline rich region, and a C-terminal plant homeodomain (PHD) finger. The FHA domain may serve as a nuclear signaling domain or as a phosphoprotein binding domain. The proline rich region is a common characteristic of trans-activating factors. The PHD finger may allow TCF-19 to interact with chromatin via methylated histone H3.


Pssm-ID: 438737 [Multi-domain]  Cd Length: 130  Bit Score: 40.09  E-value: 5.40e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574 470 TGVSRRHLEIR------WDGQVaLLADlNSTNGTTVNNAPVQEWQ---LADGDVIRLGHS 520
Cdd:cd22685   50 NLISREHAEIHaerdgnGNWKV-LIED-RSTNGTYVNDVRLQDGQrreLSDGDTITFGHK 107
FHA_DUN1-like cd22683
forkhead associated (FHA) domain found in Saccharomyces cerevisiae DNA damage response protein ...
457-518 6.00e-04

forkhead associated (FHA) domain found in Saccharomyces cerevisiae DNA damage response protein kinase DUN1 and similar proteins; DUN1 is a protein kinase that controls the DNA damage response in yeast. It phosphorylates SML1 on serine residues and cooperates with the PAN deadenylation complex in the regulation of RAD5 mRNA levels and cell survival in response to replicational stress. It contains an FHA domain, which is a small phosphopeptide recognition module.


Pssm-ID: 438735 [Multi-domain]  Cd Length: 96  Bit Score: 39.01  E-value: 6.00e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490009574 457 IGRGQDAQFRLPDTGVSRRHLEIRWDGQVALLADLNSTNGTTVNNAPV--QEWQLADGDVIRLG 518
Cdd:cd22683   25 IGRSRSCDLVLSDPSISRFHAELRLEQNGINVIDNNSANGTFINGKRIkgKTYILKNGDIIVFG 88
FHA_Kanadaptin cd22677
forkhead associated (FHA) domain found in kanadaptin and similar proteins; Kanadaptin, also ...
456-520 6.22e-04

forkhead associated (FHA) domain found in kanadaptin and similar proteins; Kanadaptin, also called human lung cancer oncogene 3 protein (HLC-3), kidney anion exchanger adapter protein, or solute carrier family 4 anion exchanger member 1 adapter protein (SLC4A1AP), is a nuclear protein widely expressed in mammalian tissues. It was originally isolated as a kidney Cl-/HCO3- anion exchanger 1 (kAE1)-binding protein. It is a highly mobile nucleocytoplasmic shuttling and multilocalizing protein. Its role in mammalian cells remains unclear. It contains an FHA domain, which is a small phosphopeptide recognition module.


Pssm-ID: 438729 [Multi-domain]  Cd Length: 106  Bit Score: 39.46  E-value: 6.22e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490009574 456 IIGRGQDAQFRLPDTGVSRRHLEIRWDGQV------ALLADLNSTNGTTVNNAPVQEWQ---LADGDVIRLGHS 520
Cdd:cd22677   25 VFGRLPGCDVVLEHPSISRYHAVLQYRGDAddhdggFYLYDLGSTHGTFLNKQRIPPKQyyrLRVGHVLKFGGS 98
FHA_FKH1-like cd22701
forkhead associated (FHA) domain found in Saccharomyces cerevisiae fork head protein homolog 1 ...
442-518 7.14e-04

forkhead associated (FHA) domain found in Saccharomyces cerevisiae fork head protein homolog 1 (FKH1), 2 (FKH2) and similar proteins; This family includes FKH1 and FKH2, as well as pre-rRNA-processing protein FHL1. FKH1 and FKH2 are forkhead transcription factors that regulate the expression of the CLB2 cluster of genes during the G2/M phase of the mitotic cell cycle. The CLB2 cluster of genes includes mitotic regulators such as CLB1, CLB2, CDC5 and CDC20, as well as SWI5 and ACE2. FKH1 and FKH2 are involved in HMRa silencing. They associate with the coding regions of active genes and influence, in opposing ways, transcriptional elongation and termination, and coordinate early transcription elongation and pre-mRNA processing. Both FKH1 and FKH2 play a role as regulators of lifespan in collaboration with the anaphase-promoting complex (APC), likely through combined regulation of stress response, genomic stability, and cell cycle regulation. They also function in controlling yeast cell morphology by preventing pseudohyphal growth and act as rate-limiting replication origin activators via their interaction with the origin recognition complex (ORC). FHL1 is a forkhead protein that controls the pre-rRNA processing machinery in conjunction with IFH1. It might act as a transcriptional regulator of genes specifically involved in that process. IFH1 convert FHL1 from a repressor to an activator. This family also includes AtFHA1 and AtFHA2, which may play a role in the control of plant organ development. AtFHA2 is specifically involved in the regulation of stamen development. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438753 [Multi-domain]  Cd Length: 106  Bit Score: 39.14  E-value: 7.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574 442 DGSGRTYQLREGSNIIGR-----------GQDAQFRlPDTGVSRRHLEIRWDgqvallADLN-------STNGTTVNNAP 503
Cdd:cd22701    6 DGDDFTYYVQKLEVVLGRnsknssstaadSVDIDLG-PSKKISRRHARIFYD------FTTQcfelsvlGRNGVKVDGIL 78
                         90
                 ....*....|....*....
gi 490009574 504 V----QEWQLADGDVIRLG 518
Cdd:cd22701   79 VkpgsPPVPLRSGSLIQIG 97
FHA_RAD53-like_rpt2 cd22690
second forkhead associated (FHA) domain found in Saccharomyces cerevisiae Serine ...
445-517 1.54e-03

second forkhead associated (FHA) domain found in Saccharomyces cerevisiae Serine/threonine-protein kinase RAD53 and similar proteins; RAD53, also called CHEK2 homolog, or serine-protein kinase 1 (Spk1), is a nuclear protein kinase that phosphorylates proteins on serine, threonine, and tyrosine. It controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints and prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5. It may be involved in the phosphorylation of RPH1. RAD53 contains two FHA domains. This model corresponds to the second one. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438742 [Multi-domain]  Cd Length: 105  Bit Score: 38.04  E-value: 1.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574 445 GRTYQ---LREGSNIIGRGQDAQFRLPDTGVSRRHLEIRWDGQ-----VALLADlNSTNGTTVNNAPVQ--EWQ-LADGD 513
Cdd:cd22690    8 NPSYPdieLTQNTTFIGRSKDCDEEITDPRISKHHCIITRKRSgkgldDVYVTD-TSTNGTFINNNRLGkgSQSlLQDGD 86

                 ....
gi 490009574 514 VIRL 517
Cdd:cd22690   87 EIVL 90
dnaA PRK14086
chromosomal replication initiator protein DnaA;
197-418 1.55e-03

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 41.35  E-value: 1.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574 197 DPRGGYPPETGgyPPQPGYPRPRHPDQGDYPeqigYPdqgGYPEQRGYPEQRGYPDQRGYQDQGRGYPDQGQGGYPPPYe 276
Cdd:PRK14086  89 DPSAGEPAPPP--PHARRTSEPELPRPGRRP----YE---GYGGPRADDRPPGLPRQDQLPTARPAYPAYQQRPEPGAW- 158
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574 277 qrppvsPGPAAGYGAPGYDQGYRQSGGYGPspgggqpgyggygeygrgparheegsyvPSGPPGPPEQ-RPAYPDQ-GGY 354
Cdd:PRK14086 159 ------PRAADDYGWQQQRLGFPPRAPYAS----------------------------PASYAPEQERdREPYDAGrPEY 204
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490009574 355 DQGYQQGATTYGRQDYGGGADYTRYTESPRVPGYAPQGGGYAEPAGRDYDYGQSGAPDY--GQPAP 418
Cdd:PRK14086 205 DQRRRDYDHPRPDWDRPRRDRTDRPEPPPGAGHVHRGGPGPPERDDAPVVPIRPSAPGPlaAQPAP 270
FHA_SLMAP cd22679
forkhead associated (FHA) domain found in sarcolemmal membrane-associated protein (SLMAP) and ...
473-518 2.62e-03

forkhead associated (FHA) domain found in sarcolemmal membrane-associated protein (SLMAP) and similar proteins; SLMAP, also called sarcolemmal-associated protein (SLAP), is a tail-anchored protein involved in fundamental cellular processes, such as myoblast fusion, cell cycle progression, and chromosomal inheritance. It is a cardiac membrane protein that plays an important role in E-C coupling and the adrenergic response of the heart. Overexpression of the SLMAP gene has been associated with diabetes and endothelial dysfunction of macro- and micro-blood vessels. SLMAP contains an N-terminal FHA domain, which is a small phosphopeptide recognition module.


Pssm-ID: 438731 [Multi-domain]  Cd Length: 126  Bit Score: 38.02  E-value: 2.62e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 490009574 473 SRRHLEIrW--DGQVaLLADLNSTNGTTVNNA-------PVQEWQLADGDVIRLG 518
Cdd:cd22679   50 SRNHALL-WydDGKF-YLQDTKSSNGTFVNNQrlskgseESEPRELHSGDIVQFG 102
FHA_PPP1R8 cd22674
forkhead associated (FHA) domain found in protein phosphatase 1 regulatory inhibitor subunit 8 ...
472-520 3.45e-03

forkhead associated (FHA) domain found in protein phosphatase 1 regulatory inhibitor subunit 8 (PPP1R8) and similar proteins; PPP1R8, also called nuclear inhibitor of protein phosphatase 1 (NIPP-1), is an inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. It may also be involved in pre-mRNA splicing and binds DNA and might act as a transcriptional repressor. PPP1R8 seems to be required for cell proliferation. PPP1R8 contains an FHA domain that mediates interactions with threonine-phosphorylated maternal embryonic leucine zipper kinase (MELK). The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438726 [Multi-domain]  Cd Length: 108  Bit Score: 37.24  E-value: 3.45e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 490009574 472 VSRRHLEIRW--DGQVALLADLNSTNGTTVNNA---PVQEWQLADGDVIRLGHS 520
Cdd:cd22674   47 CSRVHAALVYhkHLNRVFLIDLGSTHGTFVGGIrlePHKPQQLPIDSTLRFGAS 100
FHA_ZEP-like cd22702
forkhead associated (FHA) domain found in chloroplastic zeaxanthin epoxidase (ZEP) and similar ...
454-523 4.21e-03

forkhead associated (FHA) domain found in chloroplastic zeaxanthin epoxidase (ZEP) and similar proteins; ZEP, also called protein ABA DEFICIENT 1, ABA1, protein IMPAIRED IN BABA-INDUCED STERILITY 3, protein LOW EXPRESSION OF OSMOTIC STRESS-RESPONSIVE GENES 6, or protein NON-PHOTOCHEMICAL QUENCHING 2, plays an important role in the xanthophyll cycle and abscisic acid (ABA) biosynthesis. It converts zeaxanthin into antheraxanthin and subsequently violaxanthin. ZEP is required for resistance to osmotic and drought stresses, ABA-dependent stomatal closure, seed development and dormancy, modulation of defense gene expression, and disease resistance and non-photochemical quencing (NPQ). The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438754 [Multi-domain]  Cd Length: 123  Bit Score: 37.40  E-value: 4.21e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490009574 454 SNIIGRGQDAQFR-----LPDTGVSRRHLEIRWDGQVALLADLNSTNGTTVNNAPVQEWQLADGDVIRLGHSEII 523
Cdd:cd22702   33 PCIIGSDPHQAISgisvvIPSPQVSELHARITCKNGAFFLTDLGSEHGTWINDNEGRRYRAPPNFPVRLHPSDVI 107
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
127-288 5.97e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.58  E-value: 5.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574 127 PDVETHPPVIDCARPQSNHAFGAEPGVAPMSDNSSYRGGQGQGRPDEYYDDRYARPQEDPRGGPDPQGGSDPRGGYPPET 206
Cdd:PRK07764 630 AGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATP 709
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574 207 GGYPPQPGYPRPRHPDQGDYPEQIGYPDQGGYPEQRGYPEQRGYPDQRGYQDQGRGYPDQGQGGYPPPYEQRPPVSPGPA 286
Cdd:PRK07764 710 PAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDD 789

                 ..
gi 490009574 287 AG 288
Cdd:PRK07764 790 AP 791
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
140-373 8.28e-03

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 38.84  E-value: 8.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574  140 RPQSNHAFGAEPGvAPMSDNssyRGGQGQGRPDEYYDDRyARPQEDPRGGPDPQGGSDPRGGYPPETGGYPPQPGYPRPR 219
Cdd:pfam09606  95 RPQMMGPMGPGPG-GPMGQQ---MGGPGTASNLLASLGR-PQMPMGGAGFPSQMSRVGRMQPGGQAGGMMQPSSGQPGSG 169
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490009574  220 HPDQGDYPEQIGYPDQGGYPEQRGYPEQRGYPDQRGyqDQGRGYPDQGQGGYPppyeQRPPVSPGPAAGYGAPGYDQGYR 299
Cdd:pfam09606 170 TPNQMGPNGGPGQGQAGGMNGGQQGPMGGQMPPQMG--VPGMPGPADAGAQMG----QQAQANGGMNPQQMGGAPNQVAM 243
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490009574  300 QSGGYGPSPGGGQPGYGGYGEYGRGPA-RHEEGSYVPSGPPGPPEQRPAY--PDQGGYDQGYQQGATTYGRQDYGGG 373
Cdd:pfam09606 244 QQQQPQQQGQQSQLGMGINQMQQMPQGvGGGAGQGGPGQPMGPPGQQPGAmpNVMSIGDQNNYQQQQTRQQQQQQGG 320
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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