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Conserved domains on  [gi|489927451|ref|WP_003830785|]
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MULTISPECIES: TetR/AcrR family transcriptional regulator [Pseudomonadota]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 11461403)

TetR/AcrR family transcriptional regulator controls genes involved in a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

CATH:  1.10.10.60|1.10.357.10
Gene Ontology:  GO:0003677|GO:0003700|GO:0006355
PubMed:  15808743|23602932
SCOP:  4000333

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YbjK COG3226
DNA-binding transcriptional regulator YbjK [Transcription];
7-179 4.55e-12

DNA-binding transcriptional regulator YbjK [Transcription];


:

Pssm-ID: 442459 [Multi-domain]  Cd Length: 191  Bit Score: 61.49  E-value: 4.55e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927451   7 RLEVLEAIVSIIERDGLTAVTLDAVALETGMTRAGLLYHFPSREALILATHEHLTRSWEQELEASAGNTSDRATDAERHA 86
Cdd:COG3226   10 RERILEAALRVIARDGVRGVTHRAVAAEAGVPLGSTTYYFRTRDELLAAAFERLAEREAARLRALLAAADDLEDAAEALA 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927451  87 AYINTCARAAR---RVELLLILESSDNRQLGDL-------WQQVIDRWAPPAPIGNDAAELDRFISrlAADGLWIHEALS 156
Cdd:COG3226   90 DLLAELLPADRdrlLARYELYLEALRDPELRALlrrwrdrLREALARLLAALGSPDPPETARALVA--LIDGLTLHALLD 167

                        170       180
                 ....*....|....*....|...
gi 489927451 157 SRPLPEQLRKRIAARLVAMAAGP 179
Cdd:COG3226  168 PDPLTREELRAALRRLLRALLPA 190
 
Name Accession Description Interval E-value
YbjK COG3226
DNA-binding transcriptional regulator YbjK [Transcription];
7-179 4.55e-12

DNA-binding transcriptional regulator YbjK [Transcription];


Pssm-ID: 442459 [Multi-domain]  Cd Length: 191  Bit Score: 61.49  E-value: 4.55e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927451   7 RLEVLEAIVSIIERDGLTAVTLDAVALETGMTRAGLLYHFPSREALILATHEHLTRSWEQELEASAGNTSDRATDAERHA 86
Cdd:COG3226   10 RERILEAALRVIARDGVRGVTHRAVAAEAGVPLGSTTYYFRTRDELLAAAFERLAEREAARLRALLAAADDLEDAAEALA 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927451  87 AYINTCARAAR---RVELLLILESSDNRQLGDL-------WQQVIDRWAPPAPIGNDAAELDRFISrlAADGLWIHEALS 156
Cdd:COG3226   90 DLLAELLPADRdrlLARYELYLEALRDPELRALlrrwrdrLREALARLLAALGSPDPPETARALVA--LIDGLTLHALLD 167

                        170       180
                 ....*....|....*....|...
gi 489927451 157 SRPLPEQLRKRIAARLVAMAAGP 179
Cdd:COG3226  168 PDPLTREELRAALRRLLRALLPA 190
TetR_C_28 pfam17937
Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the ...
 86-177 1.94e-07

Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in CgmR (C. glutamicum multidrug-responsive transcriptional repressor), previously called CGL2612 protein. CgmR (CGL2612) from Corynebacterium glutamicum is a multidrug-resistance-related transcription factor belonging to the TetR family. It regulates expression of the immediately upstream gene cgmA (cgl2611) by binding to the operator cgmO in the cgmA promoter. The cgmA gene encodes a permease belonging to the major facilitator superfamily, a protein family composed of bacterial multidrug exporters, and the pair of CgmR and CgmA confers multidrug resistance on C. glutamicum.


Pssm-ID: 436157  Cd Length: 97  Bit Score: 47.28  E-value: 1.94e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927451   86 AAYINTCA--RAARRVELLLILESSDNRQLGDLWQQVIDRWAppAPIGNDAAELDR-FISRLAADGLWIHEALSSRPLPE 162
Cdd:pfam17937   5 RAYLRATFddAAERRLLAALLAALAEDPELLEPWREWYRRWL--ERLEADGLDPVLaTIVRLAADGLWLAELLGLPPLDP 82

                          90
                  ....*....|....*
gi 489927451  163 QLRKRIAARLVAMAA 177
Cdd:pfam17937  83 EEREALLDRLLALTR 97
PRK15008 PRK15008
HTH-type transcriptional regulator RutR; Provisional
 2-70 1.21e-05

HTH-type transcriptional regulator RutR; Provisional


Pssm-ID: 184970 [Multi-domain]  Cd Length: 212  Bit Score: 44.15  E-value: 1.21e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489927451   2 ARASKRLEVLEAIVSIIERDGLTAVTLDAVALETGMTRAGLLYHFPSREALILATHEHLTRSWEQELEA 70
Cdd:PRK15008  15 AVSAKKKAILSAALDTFSQFGFHGTRLEQIAELAGVSKTNLLYYFPSKEALYIAVLRQILDIWLAPLKA 83
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
7-76 3.17e-03

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 36.80  E-value: 3.17e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489927451   7 RLEVLEAIVSIIERDGLTAVTLDAVALETGMTRAGLLYHFPSREALILA-THEHLTRSWEQELEASAGNTS 76
Cdd:NF041196   8 RRAILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEALARAvLEEQVARLREAVEPQRAGGGS 78
 
Name Accession Description Interval E-value
YbjK COG3226
DNA-binding transcriptional regulator YbjK [Transcription];
7-179 4.55e-12

DNA-binding transcriptional regulator YbjK [Transcription];


Pssm-ID: 442459 [Multi-domain]  Cd Length: 191  Bit Score: 61.49  E-value: 4.55e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927451   7 RLEVLEAIVSIIERDGLTAVTLDAVALETGMTRAGLLYHFPSREALILATHEHLTRSWEQELEASAGNTSDRATDAERHA 86
Cdd:COG3226   10 RERILEAALRVIARDGVRGVTHRAVAAEAGVPLGSTTYYFRTRDELLAAAFERLAEREAARLRALLAAADDLEDAAEALA 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927451  87 AYINTCARAAR---RVELLLILESSDNRQLGDL-------WQQVIDRWAPPAPIGNDAAELDRFISrlAADGLWIHEALS 156
Cdd:COG3226   90 DLLAELLPADRdrlLARYELYLEALRDPELRALlrrwrdrLREALARLLAALGSPDPPETARALVA--LIDGLTLHALLD 167

                        170       180
                 ....*....|....*....|...
gi 489927451 157 SRPLPEQLRKRIAARLVAMAAGP 179
Cdd:COG3226  168 PDPLTREELRAALRRLLRALLPA 190
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
3-125 1.68e-08

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 51.44  E-value: 1.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927451   3 RASKRLEVLEAIVSIIERDGLTAVTLDAVALETGMTRAGLLYHFPSREALILATHEHLTRSWEQELEASAGNTSDRATDA 82
Cdd:COG1309    4 REATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEDPRERLR 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 489927451  83 ERHAAYINTcARAARRVELLLILESSDNRQLGDLWQQVIDRWA 125
Cdd:COG1309   84 ALLRAYLEF-LAENPALARLLLAEAAELPELRAALRALLRRLR 125
TetR_C_28 pfam17937
Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the ...
 86-177 1.94e-07

Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in CgmR (C. glutamicum multidrug-responsive transcriptional repressor), previously called CGL2612 protein. CgmR (CGL2612) from Corynebacterium glutamicum is a multidrug-resistance-related transcription factor belonging to the TetR family. It regulates expression of the immediately upstream gene cgmA (cgl2611) by binding to the operator cgmO in the cgmA promoter. The cgmA gene encodes a permease belonging to the major facilitator superfamily, a protein family composed of bacterial multidrug exporters, and the pair of CgmR and CgmA confers multidrug resistance on C. glutamicum.


Pssm-ID: 436157  Cd Length: 97  Bit Score: 47.28  E-value: 1.94e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927451   86 AAYINTCA--RAARRVELLLILESSDNRQLGDLWQQVIDRWAppAPIGNDAAELDR-FISRLAADGLWIHEALSSRPLPE 162
Cdd:pfam17937   5 RAYLRATFddAAERRLLAALLAALAEDPELLEPWREWYRRWL--ERLEADGLDPVLaTIVRLAADGLWLAELLGLPPLDP 82

                          90
                  ....*....|....*
gi 489927451  163 QLRKRIAARLVAMAA 177
Cdd:pfam17937  83 EEREALLDRLLALTR 97
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
10-55 1.09e-05

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 40.85  E-value: 1.09e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 489927451   10 VLEAIVSIIERDGLTAVTLDAVALETGMTRAGLLYHFPSREALILA 55
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEA 46
PRK15008 PRK15008
HTH-type transcriptional regulator RutR; Provisional
 2-70 1.21e-05

HTH-type transcriptional regulator RutR; Provisional


Pssm-ID: 184970 [Multi-domain]  Cd Length: 212  Bit Score: 44.15  E-value: 1.21e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489927451   2 ARASKRLEVLEAIVSIIERDGLTAVTLDAVALETGMTRAGLLYHFPSREALILATHEHLTRSWEQELEA 70
Cdd:PRK15008  15 AVSAKKKAILSAALDTFSQFGFHGTRLEQIAELAGVSKTNLLYYFPSKEALYIAVLRQILDIWLAPLKA 83
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
7-76 3.17e-03

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 36.80  E-value: 3.17e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489927451   7 RLEVLEAIVSIIERDGLTAVTLDAVALETGMTRAGLLYHFPSREALILA-THEHLTRSWEQELEASAGNTS 76
Cdd:NF041196   8 RRAILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEALARAvLEEQVARLREAVEPQRAGGGS 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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