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Conserved domains on  [gi|489734382|ref|WP_003638477|]
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YtpR family tRNA-binding protein [Lactiplantibacillus pentosus]

Protein Classification

DUF4479 and tRNA-binding domain-containing protein( domain architecture ID 10632253)

DUF4479 and tRNA-binding domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
tRNA_bind_bactPheRS cd02796
tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. ...
 97-202 1.66e-42

tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate the 2'OH of the terminal ribose of tRNA they belong functionally to class 1 aaRSs. This domain has general tRNA binding properties and is believed to direct tRNAphe to the active site of the enzyme.


:

Pssm-ID: 239196 [Multi-domain]  Cd Length: 103  Bit Score: 138.80  E-value: 1.66e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489734382  97 FVVGYVQSAEAHPKSDHLKITKTDVGADEPLQIVSGSPNMQADILVVVAKVGAMMPNGLIIWPGELRGVKSNGMIVSGRE 176
Cdd:cd02796    1 VVVGKVLEVEPHPNADKLNVCKVDIGENKPLQIVCGAPNVRAGDKVVVALPGAVLPGGLKIKKRKLRGVESEGMLCSAKE 80

                         90       100
                 ....*....|....*....|....*.
gi 489734382 177 LQLPNapQRPGALILPANYqPVGAAF 202
Cdd:cd02796   81 LGLGE--DSDGIIELPEDA-PVGTDI 103
DUF4479 pfam14794
Domain of unknown function (DUF4479); This domain family is found in bacteria, and is ...
 21-92 3.35e-28

Domain of unknown function (DUF4479); This domain family is found in bacteria, and is approximately 70 amino acids in length. The family is found in association with pfam01588.


:

Pssm-ID: 434215 [Multi-domain]  Cd Length: 71  Bit Score: 101.10  E-value: 3.35e-28
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489734382   21 PDTATQTIETHANVTRISDADSGETLGYNFFDVSKTLgSLDVNGQVHLTAEQVDQLNNLLQANDFEPELVLD 92
Cdd:pfam14794   1 PDREEQTVERKGDVVRIFDEETGETVGYNIFNASSYL-EIEGNGQVELTEEQVAKLNEALAKNGFEEELEVD 71
 
Name Accession Description Interval E-value
tRNA_bind_bactPheRS cd02796
tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. ...
 97-202 1.66e-42

tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate the 2'OH of the terminal ribose of tRNA they belong functionally to class 1 aaRSs. This domain has general tRNA binding properties and is believed to direct tRNAphe to the active site of the enzyme.


Pssm-ID: 239196 [Multi-domain]  Cd Length: 103  Bit Score: 138.80  E-value: 1.66e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489734382  97 FVVGYVQSAEAHPKSDHLKITKTDVGADEPLQIVSGSPNMQADILVVVAKVGAMMPNGLIIWPGELRGVKSNGMIVSGRE 176
Cdd:cd02796    1 VVVGKVLEVEPHPNADKLNVCKVDIGENKPLQIVCGAPNVRAGDKVVVALPGAVLPGGLKIKKRKLRGVESEGMLCSAKE 80

                         90       100
                 ....*....|....*....|....*.
gi 489734382 177 LQLPNapQRPGALILPANYqPVGAAF 202
Cdd:cd02796   81 LGLGE--DSDGIIELPEDA-PVGTDI 103
pheT PRK00629
phenylalanyl-tRNA synthetase subunit beta; Reviewed
 96-202 9.00e-34

phenylalanyl-tRNA synthetase subunit beta; Reviewed


Pssm-ID: 234804 [Multi-domain]  Cd Length: 791  Bit Score: 127.21  E-value: 9.00e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489734382  96 KFVVGYVQSAEAHPKSDHLKITKTDVGaDEPLQIVSGSPNMQADILVVVAKVGAMMPNGLIIWPGELRGVKSNGMIVSGR 175
Cdd:PRK00629  44 GVVVGKVLECEKHPNADKLRVCQVDVG-EEPLQIVCGAPNVRAGDKVPVALPGAVLPGGFKIKKAKLRGVESEGMLCSAS 122

                         90       100
                 ....*....|....*....|....*..
gi 489734382 176 ELQLPNAPQrpGALILPANYqPVGAAF 202
Cdd:PRK00629 123 ELGLSDDHD--GIIELPEDA-PVGTDA 146
pheT_bact TIGR00472
phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Every known example of ...
 96-205 1.67e-30

phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Every known example of the phenylalanyl-tRNA synthetase, except the monomeric form of mitochondrial, is an alpha 2 beta 2 heterotetramer. The beta subunits break into two subfamilies that are considerably different in sequence, length, and pattern of gaps. This model represents the subfamily that includes the beta subunit from Bacteria other than spirochetes, as well as a chloroplast-encoded form from Porphyra purpurea. The chloroplast-derived sequence is considerably shorter at the amino end. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273097 [Multi-domain]  Cd Length: 797  Bit Score: 117.78  E-value: 1.67e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489734382   96 KFVVGYVQSAEAHPKSDHLKITKTDVGADEPLQIVSGSPNMQADILVVVAKVGAMMPNGLIIWPGELRGVKSNGMIVSGR 175
Cdd:TIGR00472  45 GVVVGKVLEVEPHPNADKLKVCKVDIGEKEMLQIVCGAPNVEAGKKVAVALPGAKLPNGLKIKKSKLRGVESEGMLCSES 124

                          90       100       110
                  ....*....|....*....|....*....|...
gi 489734382  176 ELQLPNapQRPGALILPANY---QPVGAAFDFD 205
Cdd:TIGR00472 125 ELGLDE--KSDGIIVLDEDAplgTDIAEYLGLD 155
DUF4479 pfam14794
Domain of unknown function (DUF4479); This domain family is found in bacteria, and is ...
 21-92 3.35e-28

Domain of unknown function (DUF4479); This domain family is found in bacteria, and is approximately 70 amino acids in length. The family is found in association with pfam01588.


Pssm-ID: 434215 [Multi-domain]  Cd Length: 71  Bit Score: 101.10  E-value: 3.35e-28
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489734382   21 PDTATQTIETHANVTRISDADSGETLGYNFFDVSKTLgSLDVNGQVHLTAEQVDQLNNLLQANDFEPELVLD 92
Cdd:pfam14794   1 PDREEQTVERKGDVVRIFDEETGETVGYNIFNASSYL-EIEGNGQVELTEEQVAKLNEALAKNGFEEELEVD 71
EMAP COG0073
tRNA-binding EMAP/Myf domain [Translation, ribosomal structure and biogenesis];
84-203 2.19e-26

tRNA-binding EMAP/Myf domain [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439843 [Multi-domain]  Cd Length: 773  Bit Score: 106.09  E-value: 2.19e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489734382  84 DFEPELVLDtdpKFVVGYVQSAEAHPKSDHLKITKTDVGaDEPLQIVSGSPNMQADILVVVAKVGAMMPNGLIIWPGELR 163
Cdd:COG0073   34 DFEKVGGLD---GLRVGKVLEAEPHPNADKLLVLQVDVG-EETRQIVCGAPNVYAGDKVPEALVGAQVPGVVNLKPRKIR 109

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 489734382 164 GVKSNGMIVSGRELQLPNAPQrpGALILPANYqPVGAAFD 203
Cdd:COG0073  110 GVESEGMLCSAEELGLGEDHD--GILELPEDA-PPGDDAE 146
tRNA_bind pfam01588
Putative tRNA binding domain; This domain is found in prokaryotic methionyl-tRNA synthetases, ...
 97-177 2.30e-19

Putative tRNA binding domain; This domain is found in prokaryotic methionyl-tRNA synthetases, prokaryotic phenylalanyl tRNA synthetases the yeast GU4 nucleic-binding protein (G4p1 or p42, ARC1), human tyrosyl-tRNA synthetase, and endothelial-monocyte activating polypeptide II. G4p1 binds specifically to tRNA form a complex with methionyl-tRNA synthetases. In human tyrosyl-tRNA synthetase this domain may direct tRNA to the active site of the enzyme. This domain may perform a common function in tRNA aminoacylation.


Pssm-ID: 396251 [Multi-domain]  Cd Length: 96  Bit Score: 79.21  E-value: 2.30e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489734382   97 FVVGYVQSAEAHPKSDHLKITKTDVGADEPLQIVSGSPNMQADILvVVAKVGAMMPNGLiiwPGELRGVKSNGMIVSGRE 176
Cdd:pfam01588   1 LRVGKVVEAERHPNADKLLVCKVDVGEEEPRQIVSGAVNVYPPEE-LVGRLVVVVANLK---PAKLRGVESEGMILSAEE 76


                  .
gi 489734382  177 L 177
Cdd:pfam01588  77 L 77
 
Name Accession Description Interval E-value
tRNA_bind_bactPheRS cd02796
tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. ...
 97-202 1.66e-42

tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate the 2'OH of the terminal ribose of tRNA they belong functionally to class 1 aaRSs. This domain has general tRNA binding properties and is believed to direct tRNAphe to the active site of the enzyme.


Pssm-ID: 239196 [Multi-domain]  Cd Length: 103  Bit Score: 138.80  E-value: 1.66e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489734382  97 FVVGYVQSAEAHPKSDHLKITKTDVGADEPLQIVSGSPNMQADILVVVAKVGAMMPNGLIIWPGELRGVKSNGMIVSGRE 176
Cdd:cd02796    1 VVVGKVLEVEPHPNADKLNVCKVDIGENKPLQIVCGAPNVRAGDKVVVALPGAVLPGGLKIKKRKLRGVESEGMLCSAKE 80

                         90       100
                 ....*....|....*....|....*.
gi 489734382 177 LQLPNapQRPGALILPANYqPVGAAF 202
Cdd:cd02796   81 LGLGE--DSDGIIELPEDA-PVGTDI 103
pheT PRK00629
phenylalanyl-tRNA synthetase subunit beta; Reviewed
 96-202 9.00e-34

phenylalanyl-tRNA synthetase subunit beta; Reviewed


Pssm-ID: 234804 [Multi-domain]  Cd Length: 791  Bit Score: 127.21  E-value: 9.00e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489734382  96 KFVVGYVQSAEAHPKSDHLKITKTDVGaDEPLQIVSGSPNMQADILVVVAKVGAMMPNGLIIWPGELRGVKSNGMIVSGR 175
Cdd:PRK00629  44 GVVVGKVLECEKHPNADKLRVCQVDVG-EEPLQIVCGAPNVRAGDKVPVALPGAVLPGGFKIKKAKLRGVESEGMLCSAS 122

                         90       100
                 ....*....|....*....|....*..
gi 489734382 176 ELQLPNAPQrpGALILPANYqPVGAAF 202
Cdd:PRK00629 123 ELGLSDDHD--GIIELPEDA-PVGTDA 146
pheT_bact TIGR00472
phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Every known example of ...
 96-205 1.67e-30

phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Every known example of the phenylalanyl-tRNA synthetase, except the monomeric form of mitochondrial, is an alpha 2 beta 2 heterotetramer. The beta subunits break into two subfamilies that are considerably different in sequence, length, and pattern of gaps. This model represents the subfamily that includes the beta subunit from Bacteria other than spirochetes, as well as a chloroplast-encoded form from Porphyra purpurea. The chloroplast-derived sequence is considerably shorter at the amino end. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273097 [Multi-domain]  Cd Length: 797  Bit Score: 117.78  E-value: 1.67e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489734382   96 KFVVGYVQSAEAHPKSDHLKITKTDVGADEPLQIVSGSPNMQADILVVVAKVGAMMPNGLIIWPGELRGVKSNGMIVSGR 175
Cdd:TIGR00472  45 GVVVGKVLEVEPHPNADKLKVCKVDIGEKEMLQIVCGAPNVEAGKKVAVALPGAKLPNGLKIKKSKLRGVESEGMLCSES 124

                          90       100       110
                  ....*....|....*....|....*....|...
gi 489734382  176 ELQLPNapQRPGALILPANY---QPVGAAFDFD 205
Cdd:TIGR00472 125 ELGLDE--KSDGIIVLDEDAplgTDIAEYLGLD 155
DUF4479 pfam14794
Domain of unknown function (DUF4479); This domain family is found in bacteria, and is ...
 21-92 3.35e-28

Domain of unknown function (DUF4479); This domain family is found in bacteria, and is approximately 70 amino acids in length. The family is found in association with pfam01588.


Pssm-ID: 434215 [Multi-domain]  Cd Length: 71  Bit Score: 101.10  E-value: 3.35e-28
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489734382   21 PDTATQTIETHANVTRISDADSGETLGYNFFDVSKTLgSLDVNGQVHLTAEQVDQLNNLLQANDFEPELVLD 92
Cdd:pfam14794   1 PDREEQTVERKGDVVRIFDEETGETVGYNIFNASSYL-EIEGNGQVELTEEQVAKLNEALAKNGFEEELEVD 71
EMAP COG0073
tRNA-binding EMAP/Myf domain [Translation, ribosomal structure and biogenesis];
84-203 2.19e-26

tRNA-binding EMAP/Myf domain [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439843 [Multi-domain]  Cd Length: 773  Bit Score: 106.09  E-value: 2.19e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489734382  84 DFEPELVLDtdpKFVVGYVQSAEAHPKSDHLKITKTDVGaDEPLQIVSGSPNMQADILVVVAKVGAMMPNGLIIWPGELR 163
Cdd:COG0073   34 DFEKVGGLD---GLRVGKVLEAEPHPNADKLLVLQVDVG-EETRQIVCGAPNVYAGDKVPEALVGAQVPGVVNLKPRKIR 109

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 489734382 164 GVKSNGMIVSGRELQLPNAPQrpGALILPANYqPVGAAFD 203
Cdd:COG0073  110 GVESEGMLCSAEELGLGEDHD--GILELPEDA-PPGDDAE 146
tRNA_bindingDomain cd02153
The tRNA binding domain is also known as the Myf domain in literature. This domain is found in ...
 97-197 5.70e-25

The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human tyrosyl-tRNA synthetase(hTyrRS), Saccharomyces cerevisiae Arc1p, Thermus thermophilus CsaA, Aquifex aeolicus Trbp111, human p43 and human EMAP-II. PheRS, MetRS and hTyrRS aminoacylate their cognate tRNAs. Arc1p is a transactivator of yeast methionyl-tRNA and glutamyl-tRNA synthetases. The molecular chaperones Trbp111 and CsaA also contain this domain. CsaA has export related activities; Trbp111 is structure-specific recognizing the L-shape of the tRNA fold. This domain has general tRNA binding properties. In a subset of this family this domain has the added capability of a cytokine. For example the p43 component of the Human aminoacyl-tRNA synthetase complex is cleaved to release EMAP-II cytokine. EMAP-II has multiple activities during apoptosis, angiogenesis and inflammation and participates in malignant transformation. An EMAP-II-like cytokine is released from hTyrRS upon cleavage. The active cytokine heptapeptide locates to this domain. For homodimeric members of this group which include CsaA, Trbp111 and Escherichia coli MetRS this domain acts as a dimerization domain.


Pssm-ID: 239066 [Multi-domain]  Cd Length: 99  Bit Score: 93.74  E-value: 5.70e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489734382  97 FVVGYVQSAEAHPKSDHLKITKTDVGADEPLQIVSGSPNMQAD-----ILVVVAkvgammpngLIIWPGELRGVKSNGMI 171
Cdd:cd02153    1 LRVGKIVEAEPHPNADKLYVLKVDIGEEKPRQIVSGAANVYPPeelvgKKVVVA---------VNLKPKKLRGVESEGML 71

                         90       100
                 ....*....|....*....|....*.
gi 489734382 172 VSGRELQLPNapQRPGALILPANYQP 197
Cdd:cd02153   72 LSAEELGLEE--GSVGILELPEDAPV 95
tRNA_bind pfam01588
Putative tRNA binding domain; This domain is found in prokaryotic methionyl-tRNA synthetases, ...
 97-177 2.30e-19

Putative tRNA binding domain; This domain is found in prokaryotic methionyl-tRNA synthetases, prokaryotic phenylalanyl tRNA synthetases the yeast GU4 nucleic-binding protein (G4p1 or p42, ARC1), human tyrosyl-tRNA synthetase, and endothelial-monocyte activating polypeptide II. G4p1 binds specifically to tRNA form a complex with methionyl-tRNA synthetases. In human tyrosyl-tRNA synthetase this domain may direct tRNA to the active site of the enzyme. This domain may perform a common function in tRNA aminoacylation.


Pssm-ID: 396251 [Multi-domain]  Cd Length: 96  Bit Score: 79.21  E-value: 2.30e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489734382   97 FVVGYVQSAEAHPKSDHLKITKTDVGADEPLQIVSGSPNMQADILvVVAKVGAMMPNGLiiwPGELRGVKSNGMIVSGRE 176
Cdd:pfam01588   1 LRVGKVVEAERHPNADKLLVCKVDVGEEEPRQIVSGAVNVYPPEE-LVGRLVVVVANLK---PAKLRGVESEGMILSAEE 76


                  .
gi 489734382  177 L 177
Cdd:pfam01588  77 L 77
tRNA_bind_EMAP-II_like cd02799
tRNA-binding-domain-containing EMAP2-like proteins. This family contains a diverse fraction of ...
 97-191 1.87e-12

tRNA-binding-domain-containing EMAP2-like proteins. This family contains a diverse fraction of tRNA binding proteins, including Caenorhabditis elegans methionyl-tRNA synthetase (CeMetRS), human tyrosyl- tRNA synthetase (hTyrRS), Saccharomyces cerevisiae Arc1p, human p43 and EMAP2. CeMetRS and hTyrRS aminoacylate their cognate tRNAs. Arc1p is a transactivator of yeast methionyl-tRNA and glutamyl-tRNA synthetases. This domain has general tRNA binding properties. In a subset of this family this domain has the added capability of a cytokine. For example the p43 component of the Human aminoacyl-tRNA synthetase complex is cleaved to release EMAP-II cytokine. EMAP-II has multiple activities during apoptosis, angiogenesis and inflammation and participates in malignant transformation. A EMAP-II-like cytokine also is released from hTyrRS upon cleavage. The active cytokine heptapeptide locates to this domain.


Pssm-ID: 239198 [Multi-domain]  Cd Length: 105  Bit Score: 61.09  E-value: 1.87e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489734382  97 FVVGYVQSAEAHPKSDHLKITKTDVGADEPLQIVSGSPN------MQADILVVVAKVGammpngliiwPGELRGVKSNGM 170
Cdd:cd02799    8 IRVGKILKVRKHPDADSLYVEEIDLGEEEPRTIVSGLVKfvpleqMQNRLVVVLCNLK----------PRKMRGVKSQGM 77

                         90       100
                 ....*....|....*....|....*...
gi 489734382 171 IV-------SGRELQLPNAPQRPGALIL 191
Cdd:cd02799   78 VLcasnadhEKVELLEPPEGAKPGERVT 105
PheT COG0072
Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; ...
 86-204 2.01e-12

Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; Phenylalanyl-tRNA synthetase beta subunit is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439842 [Multi-domain]  Cd Length: 793  Bit Score: 65.57  E-value: 2.01e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489734382  86 EPELVLDTDPKFVVGYVQSAEAHPKSDHLKITKTDVGADEPLQIVSGSPNMQADILVVVAKVGAMMPNGLIIWPGELRGV 165
Cdd:COG0072   34 EVEGAAAVVVGVVVVVVVVEEPHPDADDLVVVVVDVGGGEVLVVVCGAANVAVGVVVVAAPGGAVLPGGFKIKKAKIRGV 113

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 489734382 166 KSNGMIVSGRELQLPNApqRPGALILPANYQPVGAAFDF 204
Cdd:COG0072  114 ESSGMLCSEEELGLGED--HDGIIVLPPDAPVGGDAREY 150
PRK12267 PRK12267
methionyl-tRNA synthetase; Reviewed
 99-190 2.75e-07

methionyl-tRNA synthetase; Reviewed


Pssm-ID: 237028 [Multi-domain]  Cd Length: 648  Bit Score: 50.18  E-value: 2.75e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489734382  99 VGYVQSAEAHPKSDHLKITKTDVGADEPLQIVSG-----SPnmqADIL----VVVA--KvgammpngliiwPGELRGVKS 167
Cdd:PRK12267 555 VAEVLEAEKVEKSDKLLKLQVDLGEEEPRQIVSGiakfyPP---EELVgkkvVVVAnlK------------PAKLMGEES 619

                         90       100
                 ....*....|....*....|....*...
gi 489734382 168 NGMIVSGRE---LQL--PNAPQRPGALI 190
Cdd:PRK12267 620 QGMILAAEDdgkLTLltVDKEVPNGSKV 647
PLN02610 PLN02610
probable methionyl-tRNA synthetase
 99-173 1.64e-05

probable methionyl-tRNA synthetase


Pssm-ID: 215329 [Multi-domain]  Cd Length: 801  Bit Score: 45.16  E-value: 1.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489734382  99 VGYVQSAEAHPKSDHLKITKTDVGADEPLQIVSG------SPNMQADILVVVAKVGammpngliiwPGELRGVKSNGMIV 172
Cdd:PLN02610 647 VGLIVKAEKHPDADSLYVEEIDVGEGAPRTVVSGlvkyipLEEMQNRKVCVLCNLK----------PAAMRGIKSQAMVL 716


                 .
gi 489734382 173 S 173
Cdd:PLN02610 717 A 717
tRNA_bind_EcMetRS_like cd02800
tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like ...
 99-190 3.24e-05

tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine transfer RNAs (tRNAmet). AaTrbp111 is structure-specific molecular chaperone recognizing the L-shape of the tRNA fold. AaTrbp111 plays a role in nuclear trafficking of tRNAs. The functional unit of EcMetRs and AaTrbp111 is a homodimer, this domain acts as the dimerization domain.


Pssm-ID: 239199 [Multi-domain]  Cd Length: 105  Bit Score: 41.33  E-value: 3.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489734382  99 VGYVQSAEAHPKSDHLKITKTDVGaDEPLQIVSG-----SPnmqADIL----VVVAKvgammpngliIWPGELRGVKSNG 169
Cdd:cd02800   13 VGKVLEAERVEGSDKLLKLTVDLG-EEERQIVSGiakfyPP---EELVgkkvVVVAN----------LKPRKLRGVESQG 78

                         90       100
                 ....*....|....*....|....*.
gi 489734382 170 MIVSGRE-----LQLPNAPQRPGALI 190
Cdd:cd02800   79 MILAAEDggklkLLTPDEEVEPGSRV 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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