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Conserved domains on  [gi|489516299|ref|WP_003421130|]
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type I methionyl aminopeptidase [Clostridioides difficile]

Protein Classification

type I methionyl aminopeptidase( domain architecture ID 10000257)

type I methionyl aminopeptidase (M24A family metallopeptidase) catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides

CATH:  3.90.230.10
EC:  3.4.11.18
Gene Ontology:  GO:0070006|GO:0046914|GO:0006508|GO:0004239
MEROPS:  M24
PubMed:  7674922

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
2-248 4.97e-160

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


:

Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 443.29  E-value: 4.97e-160
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299   2 IILKSKKEIELLREAGKIVADTHEVLRKAISPGISTLELDKIAEENIRKYNAEPSFKGYGGFPGSICASINREVVHGIPG 81
Cdd:COG0024    1 IEIKTPEEIEKMREAGRIVAEVLDELAEAVKPGVTTLELDRIAEEFIRDHGAIPAFLGYYGFPKSICTSVNEVVVHGIPS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299  82 ETILQEGDIVSLDIGAYYKGYHGDSAKTHGVGMISEEDRKLIEVTRESFYEGIKFAKLGYRLSDISHAVQTHVEKHGFSV 161
Cdd:COG0024   81 DRVLKDGDIVNIDVGAILDGYHGDSARTFVVGEVSPEARRLVEVTEEALYAGIAAAKPGNRLGDIGHAIQSYAESNGYSV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299 162 VRDLVGHGVGANLHEDPQVPNYGLPGKGPRLREGMVIAIEPMVNAGRYHVKTLSDGWTTVTIDGKKSAHYEHTIAITEHE 241
Cdd:COG0024  161 VREFVGHGIGREMHEEPQVPNYGRPGRGPRLKPGMVLAIEPMINAGTPEVKVLDDGWTVVTKDGSLSAQFEHTVAVTEDG 240


                 ....*..
gi 489516299 242 PLILTKL 248
Cdd:COG0024  241 PEILTLP 247
 
Name Accession Description Interval E-value
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
2-248 4.97e-160

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 443.29  E-value: 4.97e-160
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299   2 IILKSKKEIELLREAGKIVADTHEVLRKAISPGISTLELDKIAEENIRKYNAEPSFKGYGGFPGSICASINREVVHGIPG 81
Cdd:COG0024    1 IEIKTPEEIEKMREAGRIVAEVLDELAEAVKPGVTTLELDRIAEEFIRDHGAIPAFLGYYGFPKSICTSVNEVVVHGIPS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299  82 ETILQEGDIVSLDIGAYYKGYHGDSAKTHGVGMISEEDRKLIEVTRESFYEGIKFAKLGYRLSDISHAVQTHVEKHGFSV 161
Cdd:COG0024   81 DRVLKDGDIVNIDVGAILDGYHGDSARTFVVGEVSPEARRLVEVTEEALYAGIAAAKPGNRLGDIGHAIQSYAESNGYSV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299 162 VRDLVGHGVGANLHEDPQVPNYGLPGKGPRLREGMVIAIEPMVNAGRYHVKTLSDGWTTVTIDGKKSAHYEHTIAITEHE 241
Cdd:COG0024  161 VREFVGHGIGREMHEEPQVPNYGRPGRGPRLKPGMVLAIEPMINAGTPEVKVLDDGWTVVTKDGSLSAQFEHTVAVTEDG 240


                 ....*..
gi 489516299 242 PLILTKL 248
Cdd:COG0024  241 PEILTLP 247
PRK05716 PRK05716
methionine aminopeptidase; Validated
 1-247 2.69e-145

methionine aminopeptidase; Validated


Pssm-ID: 235576 [Multi-domain]  Cd Length: 252  Bit Score: 406.06  E-value: 2.69e-145
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299   1 MIILKSKKEIELLREAGKIVADTHEVLRKAISPGISTLELDKIAEENIRKYNAEPSFKGYGGFPGSICASINREVVHGIP 80
Cdd:PRK05716   2 AITIKTPEEIEKMRVAGRLAAEVLDEIEPHVKPGVTTKELDRIAEEYIRDQGAIPAPLGYHGFPKSICTSVNEVVCHGIP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299  81 GETILQEGDIVSLDIGAYYKGYHGDSAKTHGVGMISEEDRKLIEVTRESFYEGIKFAKLGYRLSDISHAVQTHVEKHGFS 160
Cdd:PRK05716  82 SDKVLKEGDIVNIDVTVIKDGYHGDTSRTFGVGEISPEDKRLCEVTKEALYLGIAAVKPGARLGDIGHAIQKYAEAEGFS 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299 161 VVRDLVGHGVGANLHEDPQVPNYGLPGKGPRLREGMVIAIEPMVNAGRYHVKTLSDGWTTVTIDGKKSAHYEHTIAITEH 240
Cdd:PRK05716 162 VVREYCGHGIGRKFHEEPQIPHYGAPGDGPVLKEGMVFTIEPMINAGKREVKTLKDGWTVVTKDGSLSAQYEHTVAVTED 241


                 ....*..
gi 489516299 241 EPLILTK 247
Cdd:PRK05716 242 GPEILTL 248
MetAP1 cd01086
Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 10-247 1.46e-137

Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238519 [Multi-domain]  Cd Length: 238  Bit Score: 386.08  E-value: 1.46e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299  10 IELLREAGKIVADTHEVLRKAISPGISTLELDKIAEENIRKYNAEPSFKGYGGFPGSICASINREVVHGIPGETILQEGD 89
Cdd:cd01086    1 IEGMREAGRIVAEVLDELAKAIKPGVTTKELDQIAHEFIEEHGAYPAPLGYYGFPKSICTSVNEVVCHGIPDDRVLKDGD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299  90 IVSLDIGAYYKGYHGDSAKTHGVGMISEEDRKLIEVTRESFYEGIKFAKLGYRLSDISHAVQTHVEKHGFSVVRDLVGHG 169
Cdd:cd01086   81 IVNIDVGVELDGYHGDSARTFIVGEVSEEAKKLVEVTEEALYKGIEAVKPGNRIGDIGHAIEKYAEKNGYSVVREFGGHG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489516299 170 VGANLHEDPQVPNYGLPGKGPRLREGMVIAIEPMVNAGRYHVKTLSDGWTTVTIDGKKSAHYEHTIAITEHEPLILTK 247
Cdd:cd01086  161 IGRKFHEEPQIPNYGRPGTGPKLKPGMVFTIEPMINLGTYEVVTLPDGWTVVTKDGSLSAQFEHTVLITEDGPEILTL 238
met_pdase_I TIGR00500
methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. ...
 2-248 4.43e-116

methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. Bacterial and organellar examples (type I) differ from eukaroytic and archaeal (type II) examples in lacking a region of approximately 60 amino acids between the 4th and 5th cobalt-binding ligands. This model describes type I. The role of this protein in general is to produce the mature form of cytosolic proteins by removing the N-terminal methionine. [Protein fate, Protein modification and repair]


Pssm-ID: 129591 [Multi-domain]  Cd Length: 247  Bit Score: 332.01  E-value: 4.43e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299    2 IILKSKKEIELLREAGKIVADTHEVLRKAISPGISTLELDKIAEENIRKYNAEPSFKGYGGFPGSICASINREVVHGIPG 81
Cdd:TIGR00500   1 ISLKSPDEIEKIRKAGRLAAEVLEELEREVKPGVSTKELDRIAKDFIEKHGAKPAFLGYYGFPGSVCISVNEVVIHGIPD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299   82 ETILQEGDIVSLDIGAYYKGYHGDSAKTHGVGMISEEDRKLIEVTRESFYEGIKFAKLGYRLSDISHAVQTHVEKHGFSV 161
Cdd:TIGR00500  81 KKVLKDGDIVNIDVGVIYDGYHGDTAKTFLVGKISPEAEKLLECTEESLYKAIEEAKPGNRIGEIGAAIQKYAEAKGFSV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299  162 VRDLVGHGVGANLHEDPQVPNYGLPGKGPRLREGMVIAIEPMVNAGRYHVKTLSDGWTTVTIDGKKSAHYEHTIAITEHE 241
Cdd:TIGR00500 161 VREYCGHGIGRKFHEEPQIPNYGKKFTNVRLKEGMVFTIEPMVNTGTEEITTAADGWTVKTKDGSLSAQFEHTIVITDNG 240


                  ....*..
gi 489516299  242 PLILTKL 248
Cdd:TIGR00500 241 PEILTER 247
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 11-239 6.40e-56

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 177.82  E-value: 6.40e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299   11 ELLREAGKIVADTHEVLRKAISPGISTLELDKIAEENIRKYNAepsfKGYGGFPGSICASINREVVHGIPGETILQEGDI 90
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRPGVTERELAAELEAARLRRGG----ARGPAFPPIVASGPNAAIPHYIPNDRVLKPGDL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299   91 VSLDIGAYYK-GYHGDSAKTHGVGMISEEDRKLIEVTRESFYEGIKFAKLGYRLSDISHAVQTHVEKHGFS-VVRDLVGH 168
Cdd:pfam00557  77 VLIDVGAEYDgGYCSDITRTFVVGKPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVLEEAGLGeYFPHGLGH 156

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489516299  169 GVGANLHEDPQVPNyglPGKGPRLREGMVIAIEPMVnagryhvktlsdgwttVTIDGKKSAHYEHTIAITE 239
Cdd:pfam00557 157 GIGLEVHEGPYISR---GGDDRVLEPGMVFTIEPGI----------------YFIPGWGGVRIEDTVLVTE 208
 
Name Accession Description Interval E-value
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
2-248 4.97e-160

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 443.29  E-value: 4.97e-160
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299   2 IILKSKKEIELLREAGKIVADTHEVLRKAISPGISTLELDKIAEENIRKYNAEPSFKGYGGFPGSICASINREVVHGIPG 81
Cdd:COG0024    1 IEIKTPEEIEKMREAGRIVAEVLDELAEAVKPGVTTLELDRIAEEFIRDHGAIPAFLGYYGFPKSICTSVNEVVVHGIPS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299  82 ETILQEGDIVSLDIGAYYKGYHGDSAKTHGVGMISEEDRKLIEVTRESFYEGIKFAKLGYRLSDISHAVQTHVEKHGFSV 161
Cdd:COG0024   81 DRVLKDGDIVNIDVGAILDGYHGDSARTFVVGEVSPEARRLVEVTEEALYAGIAAAKPGNRLGDIGHAIQSYAESNGYSV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299 162 VRDLVGHGVGANLHEDPQVPNYGLPGKGPRLREGMVIAIEPMVNAGRYHVKTLSDGWTTVTIDGKKSAHYEHTIAITEHE 241
Cdd:COG0024  161 VREFVGHGIGREMHEEPQVPNYGRPGRGPRLKPGMVLAIEPMINAGTPEVKVLDDGWTVVTKDGSLSAQFEHTVAVTEDG 240


                 ....*..
gi 489516299 242 PLILTKL 248
Cdd:COG0024  241 PEILTLP 247
PRK05716 PRK05716
methionine aminopeptidase; Validated
 1-247 2.69e-145

methionine aminopeptidase; Validated


Pssm-ID: 235576 [Multi-domain]  Cd Length: 252  Bit Score: 406.06  E-value: 2.69e-145
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299   1 MIILKSKKEIELLREAGKIVADTHEVLRKAISPGISTLELDKIAEENIRKYNAEPSFKGYGGFPGSICASINREVVHGIP 80
Cdd:PRK05716   2 AITIKTPEEIEKMRVAGRLAAEVLDEIEPHVKPGVTTKELDRIAEEYIRDQGAIPAPLGYHGFPKSICTSVNEVVCHGIP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299  81 GETILQEGDIVSLDIGAYYKGYHGDSAKTHGVGMISEEDRKLIEVTRESFYEGIKFAKLGYRLSDISHAVQTHVEKHGFS 160
Cdd:PRK05716  82 SDKVLKEGDIVNIDVTVIKDGYHGDTSRTFGVGEISPEDKRLCEVTKEALYLGIAAVKPGARLGDIGHAIQKYAEAEGFS 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299 161 VVRDLVGHGVGANLHEDPQVPNYGLPGKGPRLREGMVIAIEPMVNAGRYHVKTLSDGWTTVTIDGKKSAHYEHTIAITEH 240
Cdd:PRK05716 162 VVREYCGHGIGRKFHEEPQIPHYGAPGDGPVLKEGMVFTIEPMINAGKREVKTLKDGWTVVTKDGSLSAQYEHTVAVTED 241


                 ....*..
gi 489516299 241 EPLILTK 247
Cdd:PRK05716 242 GPEILTL 248
MetAP1 cd01086
Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 10-247 1.46e-137

Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238519 [Multi-domain]  Cd Length: 238  Bit Score: 386.08  E-value: 1.46e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299  10 IELLREAGKIVADTHEVLRKAISPGISTLELDKIAEENIRKYNAEPSFKGYGGFPGSICASINREVVHGIPGETILQEGD 89
Cdd:cd01086    1 IEGMREAGRIVAEVLDELAKAIKPGVTTKELDQIAHEFIEEHGAYPAPLGYYGFPKSICTSVNEVVCHGIPDDRVLKDGD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299  90 IVSLDIGAYYKGYHGDSAKTHGVGMISEEDRKLIEVTRESFYEGIKFAKLGYRLSDISHAVQTHVEKHGFSVVRDLVGHG 169
Cdd:cd01086   81 IVNIDVGVELDGYHGDSARTFIVGEVSEEAKKLVEVTEEALYKGIEAVKPGNRIGDIGHAIEKYAEKNGYSVVREFGGHG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489516299 170 VGANLHEDPQVPNYGLPGKGPRLREGMVIAIEPMVNAGRYHVKTLSDGWTTVTIDGKKSAHYEHTIAITEHEPLILTK 247
Cdd:cd01086  161 IGRKFHEEPQIPNYGRPGTGPKLKPGMVFTIEPMINLGTYEVVTLPDGWTVVTKDGSLSAQFEHTVLITEDGPEILTL 238
PRK12896 PRK12896
methionine aminopeptidase; Reviewed
 2-246 3.14e-120

methionine aminopeptidase; Reviewed


Pssm-ID: 237252 [Multi-domain]  Cd Length: 255  Bit Score: 342.97  E-value: 3.14e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299   2 IILKSKKEIELLREAGKIVADTHEVLRKAISPGISTLELDKIAEENIRKYNAEPSFKGYGGFPGSICASINREVVHGIPG 81
Cdd:PRK12896   8 MEIKSPRELEKMRKIGRIVATALKEMGKAVEPGMTTKELDRIAEKRLEEHGAIPSPEGYYGFPGSTCISVNEEVAHGIPG 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299  82 ETILQEGDIVSLDIGAYYKGYHGDSAKTHGVGMISEEDRKLIEVTRESFYEGIKFAKLGYRLSDISHAVQTHVEKHGFSV 161
Cdd:PRK12896  88 PRVIKDGDLVNIDVSAYLDGYHGDTGITFAVGPVSEEAEKLCRVAEEALWAGIKQVKAGRPLNDIGRAIEDFAKKNGYSV 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299 162 VRDLVGHGVGANLHEDPQVPN-YGLPGKGPRLREGMVIAIEPMVNAGRYHVKTLSDGWTTVTIDGKKSAHYEHTIAITEH 240
Cdd:PRK12896 168 VRDLTGHGVGRSLHEEPSVILtYTDPLPNRLLRPGMTLAVEPFLNLGAKDAETLDDGWTVVTPDKSLSAQFEHTVVVTRD 247


                 ....*.
gi 489516299 241 EPLILT 246
Cdd:PRK12896 248 GPEILT 253
met_pdase_I TIGR00500
methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. ...
 2-248 4.43e-116

methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. Bacterial and organellar examples (type I) differ from eukaroytic and archaeal (type II) examples in lacking a region of approximately 60 amino acids between the 4th and 5th cobalt-binding ligands. This model describes type I. The role of this protein in general is to produce the mature form of cytosolic proteins by removing the N-terminal methionine. [Protein fate, Protein modification and repair]


Pssm-ID: 129591 [Multi-domain]  Cd Length: 247  Bit Score: 332.01  E-value: 4.43e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299    2 IILKSKKEIELLREAGKIVADTHEVLRKAISPGISTLELDKIAEENIRKYNAEPSFKGYGGFPGSICASINREVVHGIPG 81
Cdd:TIGR00500   1 ISLKSPDEIEKIRKAGRLAAEVLEELEREVKPGVSTKELDRIAKDFIEKHGAKPAFLGYYGFPGSVCISVNEVVIHGIPD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299   82 ETILQEGDIVSLDIGAYYKGYHGDSAKTHGVGMISEEDRKLIEVTRESFYEGIKFAKLGYRLSDISHAVQTHVEKHGFSV 161
Cdd:TIGR00500  81 KKVLKDGDIVNIDVGVIYDGYHGDTAKTFLVGKISPEAEKLLECTEESLYKAIEEAKPGNRIGEIGAAIQKYAEAKGFSV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299  162 VRDLVGHGVGANLHEDPQVPNYGLPGKGPRLREGMVIAIEPMVNAGRYHVKTLSDGWTTVTIDGKKSAHYEHTIAITEHE 241
Cdd:TIGR00500 161 VREYCGHGIGRKFHEEPQIPNYGKKFTNVRLKEGMVFTIEPMVNTGTEEITTAADGWTVKTKDGSLSAQFEHTIVITDNG 240


                  ....*..
gi 489516299  242 PLILTKL 248
Cdd:TIGR00500 241 PEILTER 247
PRK12897 PRK12897
type I methionyl aminopeptidase;
1-248 5.75e-84

type I methionyl aminopeptidase;


Pssm-ID: 171806  Cd Length: 248  Bit Score: 250.72  E-value: 5.75e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299   1 MIILKSKKEIELLREAGKIVADTHEVLRKAISPGISTLELDKIAEENIRKYNAEPSFKGYGGFPGSICASINREVVHGIP 80
Cdd:PRK12897   1 MITIKTKNEIDLMHESGKLLASCHREIAKIMKPGITTKEINTFVEAYLEKHGATSEQKGYNGYPYAICASVNDEMCHAFP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299  81 GETILQEGDIVSLDIGAYYKGYHGDSAKTHGVGMISEEDRKLIEVTRESFYEGIKFAKLGYRLSDISHAVQTHVEKHGFS 160
Cdd:PRK12897  81 ADVPLTEGDIVTIDMVVNLNGGLSDSAWTYRVGKVSDEAEKLLLVAENALYKGIDQAVIGNRVGDIGYAIESYVANEGFS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299 161 VVRDLVGHGVGANLHEDPQVPNYGLPGKGPRLREGMVIAIEPMVNAGRYHVKTLSDGWTTVTIDGKKSAHYEHTIAITEH 240
Cdd:PRK12897 161 VARDFTGHGIGKEIHEEPAIFHFGKQGQGPELQEGMVITIEPIVNVGMRYSKVDLNGWTARTMDGKLSAQYEHTIAITKD 240


                 ....*...
gi 489516299 241 EPLILTKL 248
Cdd:PRK12897 241 GPIILTKL 248
PRK07281 PRK07281
methionyl aminopeptidase;
1-246 4.29e-69

methionyl aminopeptidase;


Pssm-ID: 180918  Cd Length: 286  Bit Score: 214.33  E-value: 4.29e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299   1 MIILKSKKEIELLREAGKIVADTHEVLRKAISPGISTLELDKIAEENIRKYNAEPSFKGYGG----FPGSICASINREVV 76
Cdd:PRK07281   1 MITLKSAREIEAMDRAGDFLASIHIGLRDLIKPGVDMWEVEEYVRRRCKEENVLPLQIGVDGammdYPYATCCGLNDEVA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299  77 HGIPGETILQEGDIVSLD------------------------IGAYYKGYHG---DSAKTHGVGMISEEDRKLIEVTRES 129
Cdd:PRK07281  81 HAFPRHYILKEGDLLKVDmvlsepldksivdvsklnfdnveqMKKYTESYRGglaDSCWAYAVGTPSDEVKNLMDVTKEA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299 130 FYEGIKFAKLGYRLSDISHAVQTHVEKHGFSVVRDLVGHGVGANLHEDPQVPNYGLPGKGPRLREGMVIAIEPMVNAGRY 209
Cdd:PRK07281 161 MYRGIEQAVVGNRIGDIGAAIQEYAESRGYGVVRDLVGHGVGPTMHEEPMVPNYGTAGRGLRLREGMVLTIEPMINTGTW 240

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 489516299 210 HVKT-LSDGWTTVTIDGKKSAHYEHTIAITEHEPLILT 246
Cdd:PRK07281 241 EIDTdMKTGWAHKTLDGGLSCQYEHQFVITKDGPVILT 278
PLN03158 PLN03158
methionine aminopeptidase; Provisional
 4-247 1.50e-67

methionine aminopeptidase; Provisional


Pssm-ID: 215607 [Multi-domain]  Cd Length: 396  Bit Score: 213.55  E-value: 1.50e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299   4 LKSKKEIELLREAGKIVADTHEVLRKAISPGISTLELDKIAEENIRKYNAEPSFKGYGGFPGSICASINREVVHGIPGET 83
Cdd:PLN03158 137 IKTPEQIQRMRETCRIAREVLDAAARAIKPGVTTDEIDRVVHEATIAAGGYPSPLNYHFFPKSCCTSVNEVICHGIPDAR 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299  84 ILQEGDIVSLDIGAYYKGYHGDSAKTHGVGMISEEDRKLIEVTRESFYEGIKFAKLGYRLSDISHAVQTHVEKHGFSVVR 163
Cdd:PLN03158 217 KLEDGDIVNVDVTVYYKGCHGDLNETFFVGNVDEASRQLVKCTYECLEKAIAIVKPGVRYREVGEVINRHATMSGLSVVK 296

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299 164 DLVGHGVGANLHEDPQVPNYGLPGKGPRLREGMVIAIEPMVNAGRYHVKTLSDGWTTVTIDGKKSAHYEHTIAITEHEPL 243
Cdd:PLN03158 297 SYCGHGIGELFHCAPNIPHYARNKAVGVMKAGQVFTIEPMINAGVWRDRMWPDGWTAVTADGKRSAQFEHTLLVTETGVE 376


                 ....
gi 489516299 244 ILTK 247
Cdd:PLN03158 377 VLTA 380
PRK12318 PRK12318
methionyl aminopeptidase;
2-248 2.34e-62

methionyl aminopeptidase;


Pssm-ID: 183434 [Multi-domain]  Cd Length: 291  Bit Score: 196.96  E-value: 2.34e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299   2 IILKSKKEIELLREAGKIVADTHEVLRKAISPGISTLELDKIAEENIRKYNAEPSFKGYGG--FPGSICASINREVVHGI 79
Cdd:PRK12318  41 IIIKTPEQIEKIRKACQVTARILDALCEAAKEGVTTNELDELSRELHKEYNAIPAPLNYGSppFPKTICTSLNEVICHGI 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299  80 PGETILQEGDIVSLDIGAYYKGYHGDSAKTHGVGMISEEDRKLIEVTRESFYEGIKFAKLGYRLSDISHAVQTHVEKHGF 159
Cdd:PRK12318 121 PNDIPLKNGDIMNIDVSCIVDGYYGDCSRMVMIGEVSEIKKKVCQASLECLNAAIAILKPGIPLYEIGEVIENCADKYGF 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299 160 SVVRDLVGHGVGANLHEDPQVPNYGLPGKGPrLREGMVIAIEPMVNAG-RYHVKTLSDGWTTVTIDGKKSAHYEHTIAIT 238
Cdd:PRK12318 201 SVVDQFVGHGVGIKFHENPYVPHHRNSSKIP-LAPGMIFTIEPMINVGkKEGVIDPINHWEARTCDNQPSAQWEHTILIT 279

                        250
                 ....*....|
gi 489516299 239 EHEPLILTKL 248
Cdd:PRK12318 280 ETGYEILTLL 289
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 11-239 6.40e-56

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 177.82  E-value: 6.40e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299   11 ELLREAGKIVADTHEVLRKAISPGISTLELDKIAEENIRKYNAepsfKGYGGFPGSICASINREVVHGIPGETILQEGDI 90
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRPGVTERELAAELEAARLRRGG----ARGPAFPPIVASGPNAAIPHYIPNDRVLKPGDL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299   91 VSLDIGAYYK-GYHGDSAKTHGVGMISEEDRKLIEVTRESFYEGIKFAKLGYRLSDISHAVQTHVEKHGFS-VVRDLVGH 168
Cdd:pfam00557  77 VLIDVGAEYDgGYCSDITRTFVVGKPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVLEEAGLGeYFPHGLGH 156

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489516299  169 GVGANLHEDPQVPNyglPGKGPRLREGMVIAIEPMVnagryhvktlsdgwttVTIDGKKSAHYEHTIAITE 239
Cdd:pfam00557 157 GIGLEVHEGPYISR---GGDDRVLEPGMVFTIEPGI----------------YFIPGWGGVRIEDTVLVTE 208
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
5-248 2.33e-39

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 138.03  E-value: 2.33e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299   5 KSKKEIELLREAGKIVADTHEVLRKAISPGISTLELDKIAEENIRKYNAE-PSFkgyggfpGSICAS-INREVVHGIPGE 82
Cdd:COG0006   74 KSPEEIELMRKAARIADAAHEAALAALRPGVTEREVAAELEAAMRRRGAEgPSF-------DTIVASgENAAIPHYTPTD 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299  83 TILQEGDIVSLDIGAYYKGYHGDSAKTHGVGMISEEDRKLIEVTRESFYEGIKFAKLGYRLSDISHAVQTHVEKHGFSvv 162
Cdd:COG0006  147 RPLKPGDLVLIDAGAEYDGYTSDITRTVAVGEPSDEQREIYEAVLEAQEAAIAALKPGVTGGEVDAAARDVLAEAGYG-- 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299 163 RDLV---GHGVGANLHEdpqVPNYGLPGKGPrLREGMVIAIEPMVnagrYHvktlsDGWTTVTIdgkksahyEHTIAITE 239
Cdd:COG0006  225 EYFPhgtGHGVGLDVHE---GPQISPGNDRP-LEPGMVFTIEPGI----YI-----PGIGGVRI--------EDTVLVTE 283


                 ....*....
gi 489516299 240 HEPLILTKL 248
Cdd:COG0006  284 DGAEVLTRL 292
MetAP2 cd01088
Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 10-208 1.78e-36

Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238521 [Multi-domain]  Cd Length: 291  Bit Score: 130.45  E-value: 1.78e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299  10 IELLREAGKIVADTHEVLRKAISPGISTLELDKIAEENIRKYNAEPsfkgygGFPGSIcaSINREVVHGIPG---ETILQ 86
Cdd:cd01088    1 LEKYREAGEIHRQVRKYAQSLIKPGMTLLEIAEFVENRIRELGAGP------AFPVNL--SINECAAHYTPNagdDTVLK 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299  87 EGDIVSLDIGAYYKGYHGDSAKTHGVGMISEEdrkLIEVTRESFYEGIKFAKLGYRLSDISHAVQTHVEKHGFSVVRDLV 166
Cdd:cd01088   73 EGDVVKLDFGAHVDGYIADSAFTVDFDPKYDD---LLEAAKEALNAAIKEAGPDVRLGEIGEAIEEVIESYGFKPIRNLT 149

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 489516299 167 GHGVGA-NLHEDPQVPNYGLPGKGpRLREGMVIAIEPMVNAGR 208
Cdd:cd01088  150 GHSIERyRLHAGKSIPNVKGGEGT-RLEEGDVYAIEPFATTGK 191
APP-like cd01092
Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse ...
 10-202 4.04e-34

Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline.


Pssm-ID: 238525 [Multi-domain]  Cd Length: 208  Bit Score: 121.85  E-value: 4.04e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299  10 IELLREAGKIVADTHEVLRKAISPGISTLELDKIAEENIRKYNAE-PSFkgyggfpGSICAS-INREVVHGIPGETILQE 87
Cdd:cd01092    1 IELLRKAARIADKAFEELLEFIKPGMTEREVAAELEYFMRKLGAEgPSF-------DTIVASgPNSALPHGVPSDRKIEE 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299  88 GDIVSLDIGAYYKGYHGDSAKTHGVGMISEEDRKLIEVTRESFYEGIKFAKLGYRLSDISHAVQTHVEKHGFS---VVRd 164
Cdd:cd01092   74 GDLVLIDFGAIYDGYCSDITRTVAVGEPSDELKEIYEIVLEAQQAAIKAVKPGVTAKEVDKAARDVIEEAGYGeyfIHR- 152

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 489516299 165 lVGHGVGANLHEDPQVPnyglPGKGPRLREGMVIAIEP 202
Cdd:cd01092  153 -TGHGVGLEVHEAPYIS----PGSDDVLEEGMVFTIEP 185
APP_MetAP cd01066
A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as ...
 10-242 1.96e-32

A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity compared to other metallo-aminopeptidases, suggesting they play roles in regulation of biological processes rather than general protein degradation.


Pssm-ID: 238514 [Multi-domain]  Cd Length: 207  Bit Score: 117.55  E-value: 1.96e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299  10 IELLREAGKIVADTHEVLRKAISPGISTLELDKIAEENIRKynaepsfkGYGGFPGSICASINRE--VVHGIPGETILQE 87
Cdd:cd01066    1 IARLRKAAEIAEAAMAAAAEAIRPGVTEAEVAAAIEQALRA--------AGGYPAGPTIVGSGARtaLPHYRPDDRRLQE 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299  88 GDIVSLDIGAYYKGYHGDSAKTHGVGMISEEDRKLIEVTRESFYEGIKFAKLGYRLSDISHAVQTHVEKHGFSVVR-DLV 166
Cdd:cd01066   73 GDLVLVDLGGVYDGYHADLTRTFVIGEPSDEQRELYEAVREAQEAALAALRPGVTAEEVDAAAREVLEEHGLGPNFgHRT 152

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489516299 167 GHGVGANLHEDPQVPnyglPGKGPRLREGMVIAIEP-MVNAGRYHVKtlsdgwttvtidgkksahYEHTIAITEHEP 242
Cdd:cd01066  153 GHGIGLEIHEPPVLK----AGDDTVLEPGMVFAVEPgLYLPGGGGVR------------------IEDTVLVTEDGP 207
met_pdase_II TIGR00501
methionine aminopeptidase, type II; Methionine aminopeptidase (map) is a cobalt-binding enzyme. ...
 8-212 1.19e-31

methionine aminopeptidase, type II; Methionine aminopeptidase (map) is a cobalt-binding enzyme. Bacterial and organellar examples (type I) differ from eukaroytic and archaeal (type II) examples in lacking a region of approximately 60 amino acids between the 4th and 5th cobalt-binding ligands. The role of this protein in general is to produce the mature amino end of cytosolic proteins by removing the N-terminal methionine. This model describes type II, among which the eukaryotic members typically have an N-terminal extension not present in archaeal members. It can act cotranslationally. The enzyme from rat has been shown to associate with translation initiation factor 2 (IF-2) and may have a role in translational regulation. [Protein fate, Protein modification and repair]


Pssm-ID: 129592  Cd Length: 295  Bit Score: 117.58  E-value: 1.19e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299    8 KEIELLREAGKIVADTHEVLRKAISPGISTLELDKIAEENIRKYNAEPsfkgygGFPGSIcaSINREVVHGIPG---ETI 84
Cdd:TIGR00501   3 ERAEKWIEAGKIHSKVRREAADRIVPGVKLLEVAEFVENRIRELGAEP------AFPCNI--SINECAAHFTPKagdKTV 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299   85 LQEGDIVSLDIGAYYKGYHGDSAKTHGVGMISEEdrkLIEVTRESFYEGIKFAKLGYRLSDISHAVQTHVEKHGFSVVRD 164
Cdd:TIGR00501  75 FKDGDVVKLDLGAHVDGYIADTAITVDLGDQYDN---LVKAAKDALYTAIKEIRAGVRVGEIGKAIQEVIESYGVKPISN 151

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 489516299  165 LVGHGVGA-NLHEDPQVPNYGlPGKGPRLREGMVIAIEPMVNAGRYHVK 212
Cdd:TIGR00501 152 LTGHSMAPyRLHGGKSIPNVK-ERDTTKLEEGDVVAIEPFATDGVGYVT 199
PTZ00053 PTZ00053
methionine aminopeptidase 2; Provisional
 11-211 2.25e-16

methionine aminopeptidase 2; Provisional


Pssm-ID: 240246 [Multi-domain]  Cd Length: 470  Bit Score: 77.83  E-value: 2.25e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299  11 ELLREAGKIVADTHEVLRKA--------------ISPGISTLELDKIAEENIRKYNAEPSFKGYGGFPGSiCaSINREVV 76
Cdd:PTZ00053 145 EEKRELEKLSEEQYQDLRRAaevhrqvrryaqsvIKPGVKLIDICERIESKSRELIEADGLKCGWAFPTG-C-SLNHCAA 222

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299  77 HGIPG---ETILQEGDIVSLDIGAYYKGYHGDSAKThgvgmISEEDR--KLIEVTRESFYEGIKFAKLGYRLSDISHAVQ 151
Cdd:PTZ00053 223 HYTPNtgdKTVLTYDDVCKLDFGTHVNGRIIDCAFT-----VAFNPKydPLLQATKDATNTGIKEAGIDVRLSDIGAAIQ 297

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299 152 THVEKHGFSV---------VRDLVGHGVGA-NLHEDPQVPNYGlPGKGPRLREGMVIAIEPMVNAGRYHV 211
Cdd:PTZ00053 298 EVIESYEVEIkgktypiksIRNLNGHSIGPyIIHGGKSVPIVK-GGENTRMEEGELFAIETFASTGRGYV 366
Prolidase cd01087
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline ...
 10-202 2.90e-16

Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.


Pssm-ID: 238520 [Multi-domain]  Cd Length: 243  Bit Score: 75.30  E-value: 2.90e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299  10 IELLREAGKIVADTHEVLRKAISPGISTLELDKIAEENIRKYNAEPSfkgYGgfPGSICASiNREVVHGIPGETILQEGD 89
Cdd:cd01087    1 IELMRKACDISAEAHRAAMKASRPGMSEYELEAEFEYEFRSRGARLA---YS--YIVAAGS-NAAILHYVHNDQPLKDGD 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299  90 IVSLDIGAYYKGYHGDSAKTHGV-GMISEEDRKLIEVTRESFYEGIKFAKLGYRLSDI-SHAVQTHVE---KHGF--SVV 162
Cdd:cd01087   75 LVLIDAGAEYGGYASDITRTFPVnGKFTDEQRELYEAVLAAQKAAIAACKPGVSYEDIhLLAHRVLAEglkELGIlkGDV 154

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489516299 163 RDLV-------------GHGVGANLHEdpqVPNYGLPGKGPR-LREGMVIAIEP 202
Cdd:cd01087  155 DEIVesgayakffphglGHYLGLDVHD---VGGYLRYLRRARpLEPGMVITIEP 205
PRK09795 PRK09795
aminopeptidase; Provisional
 4-202 3.87e-16

aminopeptidase; Provisional


Pssm-ID: 182080 [Multi-domain]  Cd Length: 361  Bit Score: 76.51  E-value: 3.87e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299   4 LKSKKEIELLREAGKIVADTHEVLRKAISPGISTLELDKIAEENIRKYNAE-PSFKgyggfpgSICASINREVV-HGIPG 81
Cdd:PRK09795 127 IKTPEEVEKIRLACGIADRGAEHIRRFIQAGMSEREIAAELEWFMRQQGAEkASFD-------TIVASGWRGALpHGKAS 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299  82 ETILQEGDIVSLDIGAYYKGYHGDSAKT---HGVGmISEEDRKLIEVTR---ESFYEGIKFAKLGYRLSDISHAVQTHVE 155
Cdd:PRK09795 200 DKIVAAGEFVTLDFGALYQGYCSDMTRTllvNGEG-VSAESHPLFNVYQivlQAQLAAISAIRPGVRCQQVDDAARRVIT 278

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 489516299 156 KHGFSVVRDL-VGHGVGANLHEDPQVPnyglPGKGPRLREGMVIAIEP 202
Cdd:PRK09795 279 EAGYGDYFGHnTGHAIGIEVHEDPRFS----PRDTTTLQPGMLLTVEP 322
PRK10879 PRK10879
proline aminopeptidase P II; Provisional
 1-202 3.28e-13

proline aminopeptidase P II; Provisional


Pssm-ID: 182804 [Multi-domain]  Cd Length: 438  Bit Score: 68.21  E-value: 3.28e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299   1 MIILKSKKEIELLREAGKIVADTHEVLRKAISPGISTLELD-KIAEENIRKYNAEPSFKGYGGFPGSICasinreVVHGI 79
Cdd:PRK10879 170 MRLFKSPEEIAVLRRAGEISALAHTRAMEKCRPGMFEYQLEgEIHHEFNRHGARYPSYNTIVGSGENGC------ILHYT 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299  80 PGETILQEGDIVSLDIGAYYKGYHGDSAKTHGV-GMISEEDRKLIEVTRESFYEGIKFAKLGYRLSDIS-HAVQTHVEK- 156
Cdd:PRK10879 244 ENESEMRDGDLVLIDAGCEYKGYAGDITRTFPVnGKFTPAQREIYDIVLESLETSLRLYRPGTSIREVTgEVVRIMVSGl 323

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299 157 ------------------------HGFSvvrdlvgHGVGANLHEdpqVPNYGlPGKGPRLREGMVIAIEP 202
Cdd:PRK10879 324 vklgilkgdvdqliaenahrpffmHGLS-------HWLGLDVHD---VGVYG-QDRSRILEPGMVLTVEP 382
PRK15173 PRK15173
peptidase; Provisional
 3-201 2.74e-07

peptidase; Provisional


Pssm-ID: 185095 [Multi-domain]  Cd Length: 323  Bit Score: 50.49  E-value: 2.74e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299   3 ILKSKKEIELLREAGKIVADTHEVLRKAISPGISTLELDKIAEENIRKyNAEPSFKGYGGFpgSICASINREVvhgIPGE 82
Cdd:PRK15173  94 VIKSPWEIKRLRKSAEITEYGITEASKLIRVGCTSAELTAAYKAAVMS-KSETHFSRFHLI--SVGADFSPKL---IPSN 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299  83 TILQEGDIVSLDIGAYYKGYHGDSAKTHGVGMISEEDRKLIEVTRESFYEGIKFAKLGYRLSDISHAVQTHVEKHGF-SV 161
Cdd:PRK15173 168 TKACSGDLIKFDCGVDVDGYGADIARTFVVGEPPEITRKIYQTIRTGHEHMLSMVAPGVKMKDVFDSTMEVIKKSGLpNY 247

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 489516299 162 VRDLVGHGVGA--NLHEDPQVPNYGLPGkgprLREGMVIAIE 201
Cdd:PRK15173 248 NRGHLGHGNGVflGLEESPFVSTHATES----FTSGMVLSLE 285
PRK14575 PRK14575
putative peptidase; Provisional
 3-201 4.66e-07

putative peptidase; Provisional


Pssm-ID: 173039 [Multi-domain]  Cd Length: 406  Bit Score: 50.09  E-value: 4.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299   3 ILKSKKEIELLREAGKIVADTHEVLRKAISPGISTLELDKIAEENIRKyNAEPSFKGYGGFpgSICASINREVvhgIPGE 82
Cdd:PRK14575 177 VIKSPWEIKRLRKSAEITEYGITEASKLIRVGCTSAELTAAYKAAVMS-KSETHFSRFHLI--SVGADFSPKL---IPSN 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299  83 TILQEGDIVSLDIGAYYKGYHGDSAKTHGVGMISEEDRKLIEVTRESFYEGIKFAKLGYRLSDISHAVQTHVEKHGF-SV 161
Cdd:PRK14575 251 TKACSGDLIKFDCGVDVDGYGADIARTFVVGEPPEITRKIYQTIRTGHEHMLSMVAPGVKMKDVFDSTMEVIKKSGLpNY 330

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 489516299 162 VRDLVGHGVGA--NLHEDPQVPNYGLPGkgprLREGMVIAIE 201
Cdd:PRK14575 331 NRGHLGHGNGVflGLEESPFVSTHATES----FTSGMVLSLE 368
Creatinase cd01090
Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea.
 69-204 8.17e-06

Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea.


Pssm-ID: 238523 [Multi-domain]  Cd Length: 228  Bit Score: 45.61  E-value: 8.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299  69 ASINREVVHGIPGETILQEGDIVSLDIGAYYKGYHGDSAKTHGVGMISEEDRKLIEVTRESFYEGIKFAKLGYRLSDISH 148
Cdd:cd01090   61 SGINTDGAHNPVTNRKVQRGDILSLNCFPMIAGYYTALERTLFLDEVSDAHLKIWEANVAVHERGLELIKPGARCKDIAA 140

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489516299 149 AVQTHVEK------------HGFSVVRDLVGHGVGANLHEDPQVpnyglpgkgpRLREGMVIAIEPMV 204
Cdd:cd01090  141 ELNEMYREhdllryrtfgygHSFGVLSHYYGREAGLELREDIDT----------VLEPGMVVSMEPMI 198
crvDNA_42K TIGR00495
42K curved DNA binding protein; Proteins identified by this model have been identified in a ...
 16-118 1.55e-05

42K curved DNA binding protein; Proteins identified by this model have been identified in a number of species as a nuclear (but not nucleolar) protein with a cell cycle dependence. Various names given to members of this family have included cell cycle protein p38-2G4, DNA-binding protein GBP16, and proliferation-associated protein 1. This protein is closely related to methionine aminopeptidase, a cobolt-binding protein. [Unknown function, General]


Pssm-ID: 273105  Cd Length: 390  Bit Score: 45.26  E-value: 1.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299   16 AGKIVADTHEVLRKAISPGISTLEL-----DKIAEENIRKYNAEPSFKGYGGFPgsICASINREVVHGIP----GETILQ 86
Cdd:TIGR00495  26 AGEIANNVLKSVVEACSPGAKVVDIcekgdAFIMEETAKIFKKEKEMEKGIAFP--TCISVNNCVGHFSPlksdQDYILK 103

                          90       100       110
                  ....*....|....*....|....*....|..
gi 489516299   87 EGDIVSLDIGAYYKGYHGDSAKTHGVGMISEE 118
Cdd:TIGR00495 104 EGDVVKIDLGCHIDGFIALVAHTFVVGVAQEE 135
PA2G4-like cd01089
Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family ...
 14-113 5.30e-05

Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family members have been implicated in cell cycle control.


Pssm-ID: 238522  Cd Length: 228  Bit Score: 43.09  E-value: 5.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299  14 REAGKIVADTHEVLRKAISPGISTLEL----DKIAEENIRK-YNAEPSFKGYGGFPGSIcaSINREVVHGIPG----ETI 84
Cdd:cd01089    5 KTAGQIANKVLKQVISLCVPGAKVVDLcekgDKLILEELGKvYKKEKKLEKGIAFPTCI--SVNNCVCHFSPLksdaTYT 82

                         90       100
                 ....*....|....*....|....*....
gi 489516299  85 LQEGDIVSLDIGAYYKGYHGDSAKTHGVG 113
Cdd:cd01089   83 LKDGDVVKIDLGCHIDGYIAVVAHTIVVG 111
APP cd01085
X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline ...
 167-202 5.11e-04

X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide.


Pssm-ID: 238518 [Multi-domain]  Cd Length: 224  Bit Score: 40.24  E-value: 5.11e-04
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 489516299 167 GHGVGA--NLHEDPQVPnYGLPGKGPrLREGMVIAIEP 202
Cdd:cd01085  161 GHGVGSflNVHEGPQSI-SPAPNNVP-LKAGMILSNEP 196
PRK14576 PRK14576
putative endopeptidase; Provisional
 3-201 4.32e-03

putative endopeptidase; Provisional


Pssm-ID: 173040 [Multi-domain]  Cd Length: 405  Bit Score: 38.07  E-value: 4.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299   3 ILKSKKEIELLREAGKIVADTHEVLRKAISPGISTLELDKIAEENIRKYnAEPSFKGYGGFpgSICASINREVvhgIPGE 82
Cdd:PRK14576 176 MIKSPWEIEHLRKSAEITEYGIASAAKKIRVGCTAAELTAAFKAAVMSF-PETNFSRFNLI--SVGDNFSPKI---IADT 249

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489516299  83 TILQEGDIVSLDIGAYYKGYHGDSAKTHGVGMISEEDRKLIEVTRESFYEGIKFAKLGYRLSDISHAVQTHVEKHGFS-V 161
Cdd:PRK14576 250 TPAKVGDLIKFDCGIDVAGYGADLARTFVLGEPDKLTQQIYDTIRTGHEHMLSMVAPGVKLKAVFDSTMAVIKTSGLPhY 329

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 489516299 162 VRDLVGHGVGA--NLHEDPQVPNYGLpgkgPRLREGMVIAIE 201
Cdd:PRK14576 330 NRGHLGHGDGVflGLEEVPFVSTQAT----ETFCPGMVLSLE 367
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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