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Conserved domains on  [gi|488997725|ref|WP_002908417|]
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MULTISPECIES: dihydroxyacetone kinase subunit DhaL [Streptococcus]

Protein Classification

dihydroxyacetone kinase subunit L( domain architecture ID 10020732)

dihydroxyacetone kinase subunit L (DhaL) is the ADP-binding subunit of dihydroxyacetone kinase, which catalyzes the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone via a phosphoryl group transfer from DhaL-ATP

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
dha_L_ycgS TIGR02365
dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Two types of dihydroxyacetone ...
7-186 5.89e-76

dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Two types of dihydroxyacetone kinase (glycerone kinase) are described. In yeast and a few bacteria, e.g. Citrobacter freundii, the enzyme is a single chain that uses ATP as phosphoryl donor and is designated EC 2.7.1.29. By contract, E. coli and many other bacterial species have a multisubunit form (EC 2.7.1.-) with a phosphoprotein donor related to PTS transport proteins. This family represents the subunit homologous to the E. coli YcgS subunit.


:

Pssm-ID: 274099 [Multi-domain]  Cd Length: 194  Bit Score: 226.08  E-value: 5.89e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488997725    7 KKWMQLFNEKIQNQKDYLSDLDTPIGDGDHGANMVRGMAAAVESLAAKDFASAAEVFQVVSMQLISKVGGASGPLYGSAF 86
Cdd:TIGR02365   2 LNWLKNCGDLIIENKEYLTELDRAIGDGDHGINMARGFSEVKEKLDAFKDKTIGEILKNTGMTLISKVGGASGPLYGTAF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488997725   87 MGMAKAEK-----DGKDLSGVIQAGLDMIQKRGKAVPGEKTMVDVW----------SGIPLSLQSGElthEKIGSLVEAT 151
Cdd:TIGR02365  82 LKASKALKddeilDAEDLAEILQAGLEGIQSRGKATPGEKTMVDVWapvvealrkaADEPDALAAAR---EAAEQGAEAT 158
                         170       180       190
                  ....*....|....*....|....*....|....*
gi 488997725  152 KDLKATKGRASYVGERSIGHIDPGSASSGLLFEAL 186
Cdd:TIGR02365 159 KDMQATKGRASYLGERSIGHIDPGATSSYYLFQAL 193
 
Name Accession Description Interval E-value
dha_L_ycgS TIGR02365
dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Two types of dihydroxyacetone ...
7-186 5.89e-76

dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Two types of dihydroxyacetone kinase (glycerone kinase) are described. In yeast and a few bacteria, e.g. Citrobacter freundii, the enzyme is a single chain that uses ATP as phosphoryl donor and is designated EC 2.7.1.29. By contract, E. coli and many other bacterial species have a multisubunit form (EC 2.7.1.-) with a phosphoprotein donor related to PTS transport proteins. This family represents the subunit homologous to the E. coli YcgS subunit.


Pssm-ID: 274099 [Multi-domain]  Cd Length: 194  Bit Score: 226.08  E-value: 5.89e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488997725    7 KKWMQLFNEKIQNQKDYLSDLDTPIGDGDHGANMVRGMAAAVESLAAKDFASAAEVFQVVSMQLISKVGGASGPLYGSAF 86
Cdd:TIGR02365   2 LNWLKNCGDLIIENKEYLTELDRAIGDGDHGINMARGFSEVKEKLDAFKDKTIGEILKNTGMTLISKVGGASGPLYGTAF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488997725   87 MGMAKAEK-----DGKDLSGVIQAGLDMIQKRGKAVPGEKTMVDVW----------SGIPLSLQSGElthEKIGSLVEAT 151
Cdd:TIGR02365  82 LKASKALKddeilDAEDLAEILQAGLEGIQSRGKATPGEKTMVDVWapvvealrkaADEPDALAAAR---EAAEQGAEAT 158
                         170       180       190
                  ....*....|....*....|....*....|....*
gi 488997725  152 KDLKATKGRASYVGERSIGHIDPGSASSGLLFEAL 186
Cdd:TIGR02365 159 KDMQATKGRASYLGERSIGHIDPGATSSYYLFQAL 193
Dak2 pfam02734
DAK2 domain; This domain is the predicted phosphatase domain of the dihydroxyacetone kinase ...
30-188 1.79e-55

DAK2 domain; This domain is the predicted phosphatase domain of the dihydroxyacetone kinase family.


Pssm-ID: 460668 [Multi-domain]  Cd Length: 175  Bit Score: 173.52  E-value: 1.79e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488997725   30 PIGDGDHGANMVRGMAAAVESLAAKDFASAAEVFQVVSMQLISKVGGASGPLYGSAFMGMAKA-----EKDGKDLSGVIQ 104
Cdd:pfam02734   1 PVGDGDHGTNMARGFEAALKALEDLEPASLAEVLKALAMALLSGAGGNSGPLYGQFFRGAAKAlkgkeELDAEDLAAALE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488997725  105 AGLDMIQKRGKAVPGEKTMVDVWSGIPLSLQS----GELTHEKIGSLVEA-------TKDLKATKGRASYVGERSIGHID 173
Cdd:pfam02734  81 AALEAIQARGKARPGDKTMLDVLRPAAEALEAaaeaGEDLAEALEAAVKAaeegaeaTKELLAKLGRASYLGERSIGVVD 160
                         170
                  ....*....|....*
gi 488997725  174 PGSASSGLLFEALLE 188
Cdd:pfam02734 161 PGATGLALILEALLE 175
PRK10005 PRK10005
dihydroxyacetone kinase ADP-binding subunit DhaL;
9-186 2.20e-51

dihydroxyacetone kinase ADP-binding subunit DhaL;


Pssm-ID: 182192 [Multi-domain]  Cd Length: 210  Bit Score: 164.14  E-value: 2.20e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488997725   9 WMQLFNEKIQNQKDYLSDLDTPIGDGDHGANMVRGMAAAVESLAA---KDFASaaeVFQVVSMQLISKVGGASGPLYGSA 85
Cdd:PRK10005  11 WLTRCGDIFTEESDYLTGLDREIGDADHGLNMNRGFSKVVEKLPAiadKDIGF---ILKNTGMTLLSSVGGASGPLYGTF 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488997725  86 FM-----GMAKAEKDGKDLSGVIQAGLDMIQKRGKAVPGEKTMVDVWSGIPLSLQSGELTHEKIGSL-----------VE 149
Cdd:PRK10005  88 FIraaqaTQARQSLTLEELYQMFRDGADGVISRGKAEPGDKTMCDVWVPVVESLRQSSEQNLSVPAAlnaavsiaesaAQ 167
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 488997725 150 ATKDLKATKGRASYVGERSIGHIDPGSASSGLLFEAL 186
Cdd:PRK10005 168 STITMQARKGRASYLGERSIGHQDPGATSVMFMMQAL 204
DAK1 COG2376
Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Dihydroxyacetone kinase is ...
10-186 1.12e-48

Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Dihydroxyacetone kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441943 [Multi-domain]  Cd Length: 206  Bit Score: 157.28  E-value: 1.12e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488997725  10 MQLFNEKIQNQKDYLSDLDTPIGDGDHGANMVRGMAAAVESLAAKDfASAAEVFQVVSMQLISKVGGASGPLYGSAFMGM 89
Cdd:COG2376    1 MKAVADVIAENRKFLNDLDAVVGDGDHGINMARGFDAVRAALDAAP-ADPGVVLRAAGMKVASVVGGGSGGLVGTGFLDA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488997725  90 AKAEKDGKDLSG-----VIQAGLDMIQKRGKAVPGEKTMVDVWS----GIPLSLQSGELTHEKIGSLVEA-------TKD 153
Cdd:COG2376   80 AVALKGETSPTAdqvaaALRAADEGIQGRGVAYTGDKTNFDAAApaaeAIEEAVAAGTAAAAALDEAAAAaekgaeaTRS 159
                        170       180       190
                 ....*....|....*....|....*....|...
gi 488997725 154 LKATKGRASYVGERSIGHIDPGSASSGLLFEAL 186
Cdd:COG2376  160 MGAALGRATYPGERSPGHPDPGATSVALLLNGL 192
 
Name Accession Description Interval E-value
dha_L_ycgS TIGR02365
dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Two types of dihydroxyacetone ...
7-186 5.89e-76

dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Two types of dihydroxyacetone kinase (glycerone kinase) are described. In yeast and a few bacteria, e.g. Citrobacter freundii, the enzyme is a single chain that uses ATP as phosphoryl donor and is designated EC 2.7.1.29. By contract, E. coli and many other bacterial species have a multisubunit form (EC 2.7.1.-) with a phosphoprotein donor related to PTS transport proteins. This family represents the subunit homologous to the E. coli YcgS subunit.


Pssm-ID: 274099 [Multi-domain]  Cd Length: 194  Bit Score: 226.08  E-value: 5.89e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488997725    7 KKWMQLFNEKIQNQKDYLSDLDTPIGDGDHGANMVRGMAAAVESLAAKDFASAAEVFQVVSMQLISKVGGASGPLYGSAF 86
Cdd:TIGR02365   2 LNWLKNCGDLIIENKEYLTELDRAIGDGDHGINMARGFSEVKEKLDAFKDKTIGEILKNTGMTLISKVGGASGPLYGTAF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488997725   87 MGMAKAEK-----DGKDLSGVIQAGLDMIQKRGKAVPGEKTMVDVW----------SGIPLSLQSGElthEKIGSLVEAT 151
Cdd:TIGR02365  82 LKASKALKddeilDAEDLAEILQAGLEGIQSRGKATPGEKTMVDVWapvvealrkaADEPDALAAAR---EAAEQGAEAT 158
                         170       180       190
                  ....*....|....*....|....*....|....*
gi 488997725  152 KDLKATKGRASYVGERSIGHIDPGSASSGLLFEAL 186
Cdd:TIGR02365 159 KDMQATKGRASYLGERSIGHIDPGATSSYYLFQAL 193
Dak2 pfam02734
DAK2 domain; This domain is the predicted phosphatase domain of the dihydroxyacetone kinase ...
30-188 1.79e-55

DAK2 domain; This domain is the predicted phosphatase domain of the dihydroxyacetone kinase family.


Pssm-ID: 460668 [Multi-domain]  Cd Length: 175  Bit Score: 173.52  E-value: 1.79e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488997725   30 PIGDGDHGANMVRGMAAAVESLAAKDFASAAEVFQVVSMQLISKVGGASGPLYGSAFMGMAKA-----EKDGKDLSGVIQ 104
Cdd:pfam02734   1 PVGDGDHGTNMARGFEAALKALEDLEPASLAEVLKALAMALLSGAGGNSGPLYGQFFRGAAKAlkgkeELDAEDLAAALE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488997725  105 AGLDMIQKRGKAVPGEKTMVDVWSGIPLSLQS----GELTHEKIGSLVEA-------TKDLKATKGRASYVGERSIGHID 173
Cdd:pfam02734  81 AALEAIQARGKARPGDKTMLDVLRPAAEALEAaaeaGEDLAEALEAAVKAaeegaeaTKELLAKLGRASYLGERSIGVVD 160
                         170
                  ....*....|....*
gi 488997725  174 PGSASSGLLFEALLE 188
Cdd:pfam02734 161 PGATGLALILEALLE 175
PRK10005 PRK10005
dihydroxyacetone kinase ADP-binding subunit DhaL;
9-186 2.20e-51

dihydroxyacetone kinase ADP-binding subunit DhaL;


Pssm-ID: 182192 [Multi-domain]  Cd Length: 210  Bit Score: 164.14  E-value: 2.20e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488997725   9 WMQLFNEKIQNQKDYLSDLDTPIGDGDHGANMVRGMAAAVESLAA---KDFASaaeVFQVVSMQLISKVGGASGPLYGSA 85
Cdd:PRK10005  11 WLTRCGDIFTEESDYLTGLDREIGDADHGLNMNRGFSKVVEKLPAiadKDIGF---ILKNTGMTLLSSVGGASGPLYGTF 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488997725  86 FM-----GMAKAEKDGKDLSGVIQAGLDMIQKRGKAVPGEKTMVDVWSGIPLSLQSGELTHEKIGSL-----------VE 149
Cdd:PRK10005  88 FIraaqaTQARQSLTLEELYQMFRDGADGVISRGKAEPGDKTMCDVWVPVVESLRQSSEQNLSVPAAlnaavsiaesaAQ 167
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 488997725 150 ATKDLKATKGRASYVGERSIGHIDPGSASSGLLFEAL 186
Cdd:PRK10005 168 STITMQARKGRASYLGERSIGHQDPGATSVMFMMQAL 204
DAK1 COG2376
Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Dihydroxyacetone kinase is ...
10-186 1.12e-48

Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Dihydroxyacetone kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441943 [Multi-domain]  Cd Length: 206  Bit Score: 157.28  E-value: 1.12e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488997725  10 MQLFNEKIQNQKDYLSDLDTPIGDGDHGANMVRGMAAAVESLAAKDfASAAEVFQVVSMQLISKVGGASGPLYGSAFMGM 89
Cdd:COG2376    1 MKAVADVIAENRKFLNDLDAVVGDGDHGINMARGFDAVRAALDAAP-ADPGVVLRAAGMKVASVVGGGSGGLVGTGFLDA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488997725  90 AKAEKDGKDLSG-----VIQAGLDMIQKRGKAVPGEKTMVDVWS----GIPLSLQSGELTHEKIGSLVEA-------TKD 153
Cdd:COG2376   80 AVALKGETSPTAdqvaaALRAADEGIQGRGVAYTGDKTNFDAAApaaeAIEEAVAAGTAAAAALDEAAAAaekgaeaTRS 159
                        170       180       190
                 ....*....|....*....|....*....|...
gi 488997725 154 LKATKGRASYVGERSIGHIDPGSASSGLLFEAL 186
Cdd:COG2376  160 MGAALGRATYPGERSPGHPDPGATSVALLLNGL 192
PRK14479 PRK14479
dihydroxyacetone kinase; Provisional
3-188 2.43e-44

dihydroxyacetone kinase; Provisional


Pssm-ID: 237723 [Multi-domain]  Cd Length: 568  Bit Score: 154.58  E-value: 2.43e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488997725   3 AARAKKWMQLFNEKIQNQKDYLSDLDTPIGDGDHGANMVRGMAAAVESL--AAKDFASAAEVFQVVSMQLISKVGGASGP 80
Cdd:PRK14479 361 AANLVAALDAVAEALIDNEDELGELDAVAGDGDHGIGMARGSKAALAAAraAVEAGAGAGSVLAAAGDAWADHAGGTSGP 440
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488997725  81 LYGSAFMGMAKA-----EKDGKDLSGVIQAGLDMIQKRGKAVPGEKTMVDVWsgIPL------SLQSGELTHEKIGSLV- 148
Cdd:PRK14479 441 LWGTALRAAGKAlgdkdEPTAADFAAAVRAAVDAIQELGGAQVGDKTMVDAL--VPFadaleaAAAAGADLAEAWAAAAe 518
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 488997725 149 ------EATKDLKATKGRASYVGERSIGHIDPGSASSGLLFEALLE 188
Cdd:PRK14479 519 aaeegaEATADLVPRMGRARYLGERSLGTPDAGAVSLALIFTAIAG 564
PTZ00375 PTZ00375
dihydroxyacetone kinase-like protein; Provisional
15-189 1.74e-24

dihydroxyacetone kinase-like protein; Provisional


Pssm-ID: 185583 [Multi-domain]  Cd Length: 584  Bit Score: 99.50  E-value: 1.74e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488997725  15 EKIQNQKDYLSDLDTPIGDGDHGANMVRGMAAAVESLAAKDF-ASAAEVFQVVSMQLISKVGGASGPLYGSAFMGMAKA- 92
Cdd:PTZ00375 387 ETLIESENYLNELDAEVGDGDLGSGLERSSKAVLESLPYLPLeANVRKTLTLISKAVADAFGGSSGPLYGAFLLGGANAl 466
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488997725  93 ------EKDGKDLSGVIQAGLDMIQKRGKAVPGEKTMVDVWSGIPLSLQSG-------------ELTHEKIGSLVEATKD 153
Cdd:PTZ00375 467 aealngGNAVDAVRAALAAGSHSIQELGGARVGDRTMVDVLIPFAEALNSCpsvneaasspellKACSEEAREAAEATAL 546
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 488997725 154 LKATKGRASYVGERSIGHIDPGSASSGLLFEALLET 189
Cdd:PTZ00375 547 LPAKHGRSRYLEGKELGKKDPGAELVVAWVEALASE 582
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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