|
Name |
Accession |
Description |
Interval |
E-value |
| PRK07269 |
PRK07269 |
cystathionine gamma-synthase; Reviewed |
1-363 |
0e+00 |
|
cystathionine gamma-synthase; Reviewed
Pssm-ID: 235983 Cd Length: 364 Bit Score: 721.99 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 1 MTQEYQLETILAHAGINSDEATGALASPIHFSTTYQHPEFGHSTGFDYTRTKNPTRATVEKTLAAIEKADYAIATSSGMS 80
Cdd:PRK07269 1 MSKDLHINTILAQAGIKSDEATGALVTPLHFSTTYQHPEFGQSTGFDYTRTKNPTRAKLEETLAAIESADYALATSSGMS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 81 AIVLAFEIFPVGSKVVAARDLYGGSFRWFNDKEKEGRFFFEYTNTEDEMIAAITEDTDIVYIETPTNPLMIEFDIEKVAK 160
Cdd:PRK07269 81 AIVLAFSVFPVGSKVVAVRDLYGGSFRWFNQQEKEGRFHFTYANTEEELIAAIEEDTDIVYIETPTNPLMVEFDIEKVAK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 161 IAHDKGAVVIVDNTFYSPIYQTPITQGADIVVHSATKYLSGHNDVLAGVVVTSNQEFYDKLYYNLNTTGPTLSPFDSYML 240
Cdd:PRK07269 161 LAHAKGAKVIVDNTFYSPIYQRPIELGADIVLHSATKYLSGHNDVLAGVVVTNDLELYEKLFYNLNTTGAVLSPFDSYLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 241 MRGLKTLKLRMEASTANAQEVVAFLEKSPAVKEVLYPGKGGMISFKVANQDKIPTIINSLKVFTFAESLGGVESLITYPT 320
Cdd:PRK07269 241 MRGLKTLSLRMERSTANAQEVVAFLKKSPAVKEVLYTGKGGMISFKVADETRIPHILNSLKVFTFAESLGGVESLITYPT 320
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 488979160 321 TQTHADIPGDVRASYGLTDDLLRLSIGIEAAQDLIADLENALS 363
Cdd:PRK07269 321 TQTHADIPAEVRHSYGLTDDLLRLSIGIEDARDLIADLKQALE 363
|
|
| PRK08247 |
PRK08247 |
methionine biosynthesis PLP-dependent protein; |
3-363 |
6.90e-175 |
|
methionine biosynthesis PLP-dependent protein;
Pssm-ID: 181320 [Multi-domain] Cd Length: 366 Bit Score: 490.75 E-value: 6.90e-175
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 3 QEYQLETILAHAGINSDEATGALASPIHFSTTYQHPEFGHSTGFDYTRTKNPTRATVEKTLAAIEKADYAIATSSGMSAI 82
Cdd:PRK08247 1 QMSTIETKLAQIGNRSDERTGTVNPPVYFSTAYRHEGIGESTGFDYSRTGNPTRGVLEQAIADLEGGDQGFACSSGMAAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 83 VLAFEIFPVGSKVVAARDLYGGSFRWFNDKEKEGRFFFEYTNT--EDEMIAAITEDTDIVYIETPTNPLMIEFDIEKVAK 160
Cdd:PRK08247 81 QLVMSLFRSGDELIVSSDLYGGTYRLFEEHWKKWNVRFVYVNTasLKAIEQAITPNTKAIFIETPTNPLMQETDIAAIAK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 161 IAHDKGAVVIVDNTFYSPIYQTPITQGADIVVHSATKYLSGHNDVLAGVVVTSNQEFYDKLYYNLNTTGPTLSPFDSYML 240
Cdd:PRK08247 161 IAKKHGLLLIVDNTFYTPVLQRPLEEGADIVIHSATKYLGGHNDVLAGLVVAKGQELCERLAYYQNAAGAVLSPFDSWLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 241 MRGLKTLKLRMEASTANAQEVVAFLEKSPAVKEVLYPGKGGMISFKVANQDKIPTIINSLKVFTFAESLGGVESLITYPT 320
Cdd:PRK08247 241 IRGMKTLALRMRQHEENAKAIAAFLNEQPGVTDVLYPGRGGMLSFRLQDEEWVNPFLKSLKLITFAESLGGVESFITYPA 320
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 488979160 321 TQTHADIPGDVRASYGLTDDLLRLSIGIEAAQDLIADLENALS 363
Cdd:PRK08247 321 TQTHADIPEEIRIANGVCNRLLRFSVGIENVEDLIADLKQAFK 363
|
|
| MetC |
COG0626 |
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ... |
5-363 |
7.53e-165 |
|
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 440391 [Multi-domain] Cd Length: 389 Bit Score: 466.06 E-value: 7.53e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 5 YQLETILAHAGINSDEATGALASPIHFSTTYQHPEF--------GHSTGFDYTRTKNPTRATVEKTLAAIEKADYAIATS 76
Cdd:COG0626 1 MGPATRAVHAGRDPDPQTGAVSPPIYLTSTFVFPSAealaarfaGEEGGYIYSRYGNPTRRALEEALAALEGGEAALAFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 77 SGMSAIVLA-FEIFPVGSKVVAARDLYGGSFRWFNDKEKegRFFFEYT----NTEDEMIAAITEDTDIVYIETPTNPLMI 151
Cdd:COG0626 81 SGMAAISAVlLALLKAGDHVVASDDLYGGTRRLLDKVLA--RFGIEVTfvdpTDLAAVEAAIRPNTKLVFLETPSNPTLE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 152 EFDIEKVAKIAHDKGAVVIVDNTFYSPIYQTPITQGADIVVHSATKYLSGHNDVLAGVVVTSNQEFYDKLYYNLNTTGPT 231
Cdd:COG0626 159 VVDIAAIAAIAHAAGALLVVDNTFATPLLQRPLELGADIVVHSATKYLGGHSDVLGGAVVGRDEELAERLRFLQNALGAV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 232 LSPFDSYMLMRGLKTLKLRMEASTANAQEVVAFLEKSPAVKEVLYPG----------K------GGMISFKVA-NQDKIP 294
Cdd:COG0626 239 LSPFDAWLLLRGLKTLALRMERHCENALAVAEWLEAHPAVARVYYPGlpshpghelaKrqmsgfGGMLSFELKgGREAAR 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488979160 295 TIINSLKVFTFAESLGGVESLITYPTTQTHADIPGDVRASYGLTDDLLRLSIGIEAAQDLIADLENALS 363
Cdd:COG0626 319 RFLDALKLFTLAVSLGGVESLITHPATMTHRSLPPEERAALGITDGLVRLSVGLEDVDDLIADLEQALA 387
|
|
| Cys_Met_Meta_PP |
pfam01053 |
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ... |
8-362 |
5.07e-156 |
|
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.
Pssm-ID: 395837 [Multi-domain] Cd Length: 376 Bit Score: 443.21 E-value: 5.07e-156
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 8 ETILAHAGINSDEATGALASPIHFSTTYQHPEFGHSTGFDYTRTKNPTRATVEKTLAAIEKADYAIATSSGMSAIVLA-F 86
Cdd:pfam01053 1 DTLAVHAGQRPDPQTGAVSVPIYLTSTYVFDFAGEEGGYDYSRSGNPTRDVLEERIAALEGGAAALAFSSGMAAITAAiL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 87 EIFPVGSKVVAARDLYGGSFRWFNDKEKEGRFFFEYTNTED--EMIAAITEDTDIVYIETPTNPLMIEFDIEKVAKIAHD 164
Cdd:pfam01053 81 ALLKAGDHIVATDDLYGGTYRLFNKVLPRFGIEVTFVDTSDpeDLEAAIKPNTKAVYLETPTNPLLKVVDIEAIAKLAKK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 165 KGAVVIVDNTFYSPIYQTPITQGADIVVHSATKYLSGHNDVLAGVVVTSNQEFYDKLYYNLNTTGPTLSPFDSYMLMRGL 244
Cdd:pfam01053 161 HGILVVVDNTFASPYLQRPLDLGADIVVHSATKYIGGHSDVVGGVIVVNGEELGKELYFLQNATGAVLSPFDAWLLLRGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 245 KTLKLRMEASTANAQEVVAFLEKSPAVKEVLYPG----------------KGGMISFKVAN-QDKIPTIINSLKVFTFAE 307
Cdd:pfam01053 241 KTLGLRMEQHQENAQKVAEFLESHPKVEKVYYPGlpshpghelakrqmkgFGGMLSFELKGgLEAAKKFLDNLKLFSLAV 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 488979160 308 SLGGVESLITYPTTQTHADIPGDVRASYGLTDDLLRLSIGIEAAQDLIADLENAL 362
Cdd:pfam01053 321 SLGGVESLISHPATMTHASIPPEEREAAGITDDLIRLSVGIEDVDDLIADLKQAL 375
|
|
| CGS_like |
cd00614 |
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ... |
23-363 |
3.47e-145 |
|
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.
Pssm-ID: 99738 [Multi-domain] Cd Length: 369 Bit Score: 415.45 E-value: 3.47e-145
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 23 GALASPIHFSTTYQHPEFGHST--------GFDYTRTKNPTRATVEKTLAAIEKADYAIATSSGMSAIVLAFEIF-PVGS 93
Cdd:cd00614 1 GAVAPPIYQTSTFVFPSPAEAAdlfalregGYIYSRIGNPTVDALEKKLAALEGGEAALAFSSGMAAISTVLLALlKAGD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 94 KVVAARDLYGGSFRWFNDKEKEG----RFFfeYTNTEDEMIAAITEDTDIVYIETPTNPLMIEFDIEKVAKIAHDKGAVV 169
Cdd:cd00614 81 HVVASDDLYGGTYRLFERLLPKLgievTFV--DPDDPEALEAAIKPETKLVYVESPTNPTLKVVDIEAIAELAHEHGALL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 170 IVDNTFYSPIYQTPITQGADIVVHSATKYLSGHNDVLAGVVVTSNQEFYDKLYYNLNTTGPTLSPFDSYMLMRGLKTLKL 249
Cdd:cd00614 159 VVDNTFATPYLQRPLELGADIVVHSATKYIGGHSDVIAGVVVGSGEALIQRLRFLRLALGTILSPFDAWLLLRGLKTLPL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 250 RMEASTANAQEVVAFLEKSPAVKEVLYP----------------GKGGMISFKVA-NQDKIPTIINSLKVFTFAESLGGV 312
Cdd:cd00614 239 RMERHSENALKVAEFLEKHPKVERVYYPglpshpqhelakkqmsGYGGVFSFELKgGLEAAKKFLNALKLFSLAVSLGGV 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 488979160 313 ESLITYPTTQTHADIPGDVRASYGLTDDLLRLSIGIEAAQDLIADLENALS 363
Cdd:cd00614 319 ESLVEHPASMTHSQLPPEERAAAGITPGLVRLSVGIEDVEDLIADLEQALK 369
|
|
| PRK07811 |
PRK07811 |
cystathionine gamma-synthase; Provisional |
7-363 |
9.76e-126 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 236104 [Multi-domain] Cd Length: 388 Bit Score: 366.66 E-value: 9.76e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 7 LETILAHAGINSDEATGALASPIHFSTTY-QHPEFGHSTGFDYTRTKNPTRATVEKTLAAIEKADYAIATSSGMSAI-VL 84
Cdd:PRK07811 13 FATRAIHAGYEPDPATGAVNPPIYASSTFaQDGVGGLRGGYEYARTGNPTRTALEEQLAALEGGAYGRAFSSGMAATdCL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 85 AFEIFPVGSKVVAARDLYGGSFRWFNdkEKEGRFFFEYTNTE----DEMIAAITEDTDIVYIETPTNPLMIEFDIEKVAK 160
Cdd:PRK07811 93 LRAVLRPGDHIVIPNDAYGGTFRLID--KVFTRWGVEYTPVDlsdlDAVRAAITPRTKLIWVETPTNPLLSITDIAALAE 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 161 IAHDKGAVVIVDNTFYSPIYQTPITQGADIVVHSATKYLSGHNDVLAGVVVTSNQEFYDKLYYNLNTTGPTLSPFDSYML 240
Cdd:PRK07811 171 LAHDAGAKVVVDNTFASPYLQQPLALGADVVVHSTTKYIGGHSDVVGGALVTNDEELDEAFAFLQNGAGAVPGPFDAYLT 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 241 MRGLKTLKLRMEASTANAQEVVAFLEKSPAVKEVLYPGK----------------GGMISFKVANQDKIP-TIINSLKVF 303
Cdd:PRK07811 251 LRGLKTLAVRMDRHSENAEAVAEFLAGHPEVSTVLYPGLpshpghevaarqmrgfGGMVSVRLAGGEEAArDFCARTKVF 330
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 304 TFAESLGGVESLITYPTTQTHADIPGdvrASYGLTDDLLRLSIGIEAAQDLIADLENALS 363
Cdd:PRK07811 331 TLAESLGGVESLIEHPSAMTHASTAG---SQLEVPDDLVRLSVGIEDVADLLADLEQALG 387
|
|
| PRK07671 |
PRK07671 |
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase; |
8-363 |
2.37e-122 |
|
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;
Pssm-ID: 181076 [Multi-domain] Cd Length: 377 Bit Score: 357.50 E-value: 2.37e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 8 ETILAHAGINSDEATGALASPIHFSTTYQHPEFGHSTGFDYTRTKNPTRATVEKTLAAIEKADYAIATSSGMSAIVLAFE 87
Cdd:PRK07671 4 KTKLIHGGIIGDPSTGAVSVPIYQVSTYKQEAVGKHQGYEYSRTGNPTRAALEELIAVLEGGHAGFAFGSGMAAITAVMM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 88 IFPVGSKVVAARDLYGGSFRW----FNDKEKEGRFFfeYTNTEDEMIAAITEDTDIVYIETPTNPLMIEFDIEKVAKIAH 163
Cdd:PRK07671 84 LFSSGDHVILTDDVYGGTYRVmtkvLNRFGIEHTFV--DTSNLEEVEEAIRPNTKAIYVETPTNPLLKITDIKKISTIAK 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 164 DKGAVVIVDNTFYSPIYQTPITQGADIVVHSATKYLSGHNDVLAGVVVTSNQEFYDKLYYNLNTTGPTLSPFDSYMLMRG 243
Cdd:PRK07671 162 EKGLLTIVDNTFMTPYWQSPISLGADIVLHSATKYLGGHSDVVAGLVVVNSPELAEDLHFVQNSTGGILGPQDSWLLLRG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 244 LKTLKLRMEASTANAQEVVAFLEKSPAVKEVLYPGK----------------GGMISFKVANQDKIPTIINSLKVFTFAE 307
Cdd:PRK07671 242 LKTLGIRMEEHETNSRAIAEFLNNHPAVNKVYYPGLpshpnhelakeqangfGGMISFDVGSEETANKVLERLQYFTLAE 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 488979160 308 SLGGVESLITYPTTQTHADIPGDVRASYGLTDDLLRLSIGIEAAQDLIADLENALS 363
Cdd:PRK07671 322 SLGAVESLISIPSQMTHASIPADRRKELGITDGLIRISVGIEDGEDLIEDLAQALA 377
|
|
| PRK08045 |
PRK08045 |
cystathionine gamma-synthase; Provisional |
9-362 |
1.37e-113 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 169194 [Multi-domain] Cd Length: 386 Bit Score: 335.71 E-value: 1.37e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 9 TILAHAGINSDEATGALASPIHFSTTYQHPEFGHSTGFDYTRTKNPTRATVEKTLAAIEKADYAIATSSGMSAIVLAFEI 88
Cdd:PRK08045 7 TIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIHLVTTV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 89 F-PVGSKVVAARDLYGGSFRWFNDKEKEGRFFFEYTNTEDE--MIAAITEDTDIVYIETPTNPLMIEFDIEKVAKIAHDK 165
Cdd:PRK08045 87 FlKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEqaLRAALAEKPKLVLVESPSNPLLRVVDIAKICHLAREA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 166 GAVVIVDNTFYSPIYQTPITQGADIVVHSATKYLSGHNDVLAGVVVTSNQEFYDKLYYNLNTTGPTLSPFDSYMLMRGLK 245
Cdd:PRK08045 167 GAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGAFDSYLLLRGLR 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 246 TLKLRMEASTANAQEVVAFLEKSPAVKEVLYP----------------GKGGMISFKV-ANQDKIPTIINSLKVFTFAES 308
Cdd:PRK08045 247 TLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPslpenqgheiaarqqkGFGAMLSFELdGDEQTLRRFLGGLSLFTLAES 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 488979160 309 LGGVESLITYPTTQTHADIPGDVRASYGLTDDLLRLSIGIEAAQDLIADLENAL 362
Cdd:PRK08045 327 LGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGF 380
|
|
| PRK06176 |
PRK06176 |
cystathionine gamma-synthase; |
6-363 |
6.27e-112 |
|
cystathionine gamma-synthase;
Pssm-ID: 180443 [Multi-domain] Cd Length: 380 Bit Score: 331.09 E-value: 6.27e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 6 QLETILAHAGINSDEATGALASPIHFSTTYQHPEFGHSTGFDYTRTKNPTRATVEKTLAAIEKADYAIATSSGMSAIVLA 85
Cdd:PRK06176 2 RMQTKLIHGGISEDTTTGAVSVPIYQTSTYRQDAIGRPKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHAV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 86 FEIFPVGSKVVAARDLYGGSFRWFNDKEKEGRFFFEYTNTED--EMIAAITEDTDIVYIETPTNPLMIEFDIEKVAKIAH 163
Cdd:PRK06176 82 FSLFQSGDHVLLGDDVYGGTFRLFDKVLVKNGLSCTIIDTSDlsQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVAK 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 164 DKGAVVIVDNTFYSPIYQTPITQGADIVVHSATKYLSGHNDVLAGVVVTSNQEFYDKLYYNLNTTGPTLSPFDSYMLMRG 243
Cdd:PRK06176 162 DHGLLTIVDNTFATPYYQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQRG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 244 LKTLKLRMEASTANAQEVVAFLEKSPAVKEVLYPGK----------------GGMISFKVANQDKIPTIINSLKVFTFAE 307
Cdd:PRK06176 242 IKTLGLRMEAHQKNALCVAEFLEKHPKVEKVYYPGLpthpnhelakkqmrgfSGMLSFTLKNDSEAVAFVESLKLFILGE 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 488979160 308 SLGGVESLITYPTTQTHADIPGDVRASYGLTDDLLRLSIGIEAAQDLIADLENALS 363
Cdd:PRK06176 322 SLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFA 377
|
|
| PRK08064 |
PRK08064 |
cystathionine beta-lyase MetC; |
1-363 |
8.76e-112 |
|
cystathionine beta-lyase MetC;
Pssm-ID: 236146 [Multi-domain] Cd Length: 390 Bit Score: 331.35 E-value: 8.76e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 1 MTQEYQLETILAHAGINSDEATGALASPIHFSTTYQHPEFGHSTGFDYTRTKNPTRATVEKTLAAIEKADYAIATSSGMS 80
Cdd:PRK08064 1 MAMSYSIDTLLLHNQYKHDKQTGAVNVPIYHASTFHQFDFDTFGKYDYSRSGNPTREALEDIIAELEGGTKGFAFASGMA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 81 AIVLAFEIFPVGSKVVAARDLYGGSFRWFNdkEKEGRFFFEYTNTE----DEMIAAITEDTDIVYIETPTNPLMIEFDIE 156
Cdd:PRK08064 81 AISTAFLLLSKGDHVLISEDVYGGTYRMIT--EVLSRFGIEHTFVDmtnlEEVAQNIKPNTKLFYVETPSNPLLKVTDIR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 157 KVAKIAHDKGAVVIVDNTFYSPIYQTPITQGADIVVHSATKYLSGHNDVLAGVVVTSNQEFYDKLYYNLNTTGPTLSPFD 236
Cdd:PRK08064 159 GVVKLAKAIGCLTFVDNTFLTPLLQKPLDLGADVVLHSATKFLAGHSDVLAGLAVVKDEELAQKLYFLQNSFGAVLGVQD 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 237 SYMLMRGLKTLKLRMEASTANAQEVVAFLEKSPAVKEVLYPG----------------KGGMISFKVANQDKIPTIINSL 300
Cdd:PRK08064 239 CWLVLRGLKTLHVRLEHSSETANKIALYLQEHPKVQNVYYPGlqthlgfdiqqsqatsAGAVLSFTLQSEEAVRQFVSHV 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488979160 301 KVFTFAESLGGVESLITYPTTQTHADIPGDVRASYGLTDDLLRLSIGIEAAQDLIADLENALS 363
Cdd:PRK08064 319 KLPVFAVSLGAVESILSYPAKMSHAAMPKEERDERGITDGLLRLSVGLENVDDLIADFEQALS 381
|
|
| PRK08776 |
PRK08776 |
O-succinylhomoserine (thiol)-lyase; |
9-362 |
7.46e-106 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181554 [Multi-domain] Cd Length: 405 Bit Score: 316.55 E-value: 7.46e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 9 TILAHAGINSDEATGALASPIHFSTTYQHPEFGHSTGFDYTRTKNPTRATVEKTLAAIEKADYAIATSSGMSAIVLAFE- 87
Cdd:PRK08776 15 TAAVRAGIDRDTAYGAVTPPIVLSSNFSFDGFGNKRQYDYTRSGNPTRDLLGEALAELEGGAGGVITATGMGAINLVLNa 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 88 IFPVGSKVVAARDLYGGSFRWFNDKEKEGRFFFEYTNTED--EMIAAITEDTDIVYIETPTNPLMIEFDIEKVAKIAHDK 165
Cdd:PRK08776 95 LLQPGDTLVVPHDAYGGSWRLFNALAKKGHFALITADLTDprSLADALAQSPKLVLIETPSNPLLRITDLRFVIEAAHKV 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 166 GAVVIVDNTFYSPIYQTPITQGADIVVHSATKYLSGHNDVLAGVVVTSNQEFYDKLYYNLNTTGPTLSPFDSYMLMRGLK 245
Cdd:PRK08776 175 GALTVVDNTFLSPALQKPLEFGADLVLHSTTKYINGHSDVVGGAVVARDAELHQQLVWWANALGLTGSPFDAFLTLRGLR 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 246 TLKLRMEASTANAQEVVAFLEKSPAVKEVLYPGK----------------GGMISFKVAN-QDKIPTIINSLKVFTFAES 308
Cdd:PRK08776 255 TLDARLRVHQENADAIAALLDGHAAVNQVYYPGLashpghalaarqqkgfGAMLSFELEGgEAAVRAFVDGLRYFTLAES 334
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 488979160 309 LGGVESLITYPTTQTHADIPGDVRASYGLTDDLLRLSIGIEAAQDLIADLENAL 362
Cdd:PRK08776 335 LGGVESLIAHPASMTHAAMTAEARAAAGISDGLLRLSVGIESAEDLLIDLRAGL 388
|
|
| MET17 |
COG2873 |
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid ... |
1-362 |
9.57e-104 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid transport and metabolism]; O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 442120 [Multi-domain] Cd Length: 428 Bit Score: 311.96 E-value: 9.57e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 1 MT-QEYQLETILAHAGINSDEATGALASPIHFSTTYQHPEFGHS--------TGFDYTRTKNPTRATVEKTLAAIEKADY 71
Cdd:COG2873 1 MTeKKYGFETLALHAGQEPDPTTGARAVPIYQTTSYVFDDAEHAadlfalkePGNIYTRIMNPTTDVLEKRIAALEGGVA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 72 AIATSSGMSAIVLA-FEIFPVGSKVVAARDLYGGSFRWFNDKEKegRF-----FFEyTNTEDEMIAAITEDTDIVYIETP 145
Cdd:COG2873 81 ALATASGQAAITLAiLNLAEAGDHIVASSSLYGGTYNLFAHTLP--RLgievrFVD-PDDPEAFEAAIDPNTKAIFGETI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 146 TNPLMIEFDIEKVAKIAHDKGAVVIVDNTFYSPIYQTPITQGADIVVHSATKYLSGHNDVLAGVVVTS-------NQEF- 217
Cdd:COG2873 158 GNPALDVLDIEAIAEIAHEHGVPLIVDNTFATPYLCRPIEHGADIVVHSATKYIGGHGTSIGGVIVDGgnfdwaaNGKFp 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 218 --------YDKLYYN----------------LNTTGPTLSPFDSYMLMRGLKTLKLRMEASTANAQEVVAFLEKSPAVKE 273
Cdd:COG2873 238 eltepdpsYHGLVYTeafgnaafitkarvqlLRDLGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLEAHPKVAW 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 274 VLYP-----------------GKGGMISFKVA-NQDKIPTIINSLKVFTFAESLGGVESLITYPTTQTHADIPGDVRASY 335
Cdd:COG2873 318 VNYPglpshpyhelaqkylpkGAGGVLTFGLKgGREAGKKFIDSLKLFSHLANIGDAKSLVIHPASTTHSQLSEEEQAAA 397
|
410 420
....*....|....*....|....*..
gi 488979160 336 GLTDDLLRLSIGIEAAQDLIADLENAL 362
Cdd:COG2873 398 GVTPDLIRLSVGIEDIDDIIADLDQAL 424
|
|
| PRK08861 |
PRK08861 |
O-succinylhomoserine (thiol)-lyase; |
4-364 |
6.16e-103 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181567 [Multi-domain] Cd Length: 388 Bit Score: 308.75 E-value: 6.16e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 4 EYQLETILAHAGINSDEATGALASPIHFSTTYQHPEFGHSTGFDYTRTKNPTRATVEKTLAAIEKADYAIATSSGMSAIV 83
Cdd:PRK08861 3 TRKPATIAVRTGIESDSQYHAVVPPIYLSTNYGFPAFGEVPKYDYTRSGNPNRGLLEQTLSELESGKGAVVTNCGTSALN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 84 LAFEIFPVGSK-VVAARDLYGGSFRWFNDKEKEGRFFFEYTNTEDE--MIAAITEDTDIVYIETPTNPLMIEFDIEKVAK 160
Cdd:PRK08861 83 LWVSALLGPDDlIVAPHDCYGGTYRLFNTRANKGDFKVQFVDQSDAaaLDAALAKKPKLILLETPSNPLVRVVDIAELCQ 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 161 IAHDKGAVVIVDNTFYSPIYQTPITQGADIVVHSATKYLSGHNDVLAGVVVTSNQEFYDKLYYNLNTTGPTLSPFDSYML 240
Cdd:PRK08861 163 KAKAVGALVAVDNTFLTPVLQKPLELGADFVIHSTTKYINGHSDVIGGVLITKTKEHAEELAWWGNCIGATGTPFDSYMT 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 241 MRGLKTLKLRMEASTANAQEVVAFLEKSPAVKEVLYP----------------GKGGMISFKVANQ-DKIPTIINSLKVF 303
Cdd:PRK08861 243 LRGIRTLGARMRVHEESAQQILAYLQTQSLVGTIYHPslpehpgheiakkqqsGFGSMLSFEFAGSfEQLKVFVKALALF 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488979160 304 TFAESLGGVESLITYPTTQTHADIPGDVRASYGLTDDLLRLSIGIEAAQDLIADLENALSL 364
Cdd:PRK08861 323 SLAESLGGVESLICHPASMTHRAMGEEALAEAGVSQQLLRLSVGLEDAQDLIADLDQAFAK 383
|
|
| PRK08574 |
PRK08574 |
cystathionine gamma-synthase family protein; |
9-363 |
7.75e-99 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236298 [Multi-domain] Cd Length: 385 Bit Score: 298.13 E-value: 7.75e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 9 TILAHAGINSDEaTGALASPIHFSTTYQHPEFGHST--GFD--YTRTKNPTRATVEKTLAAIEKADYAIATSSGMSAI-V 83
Cdd:PRK08574 5 TDAVRGYRGSDP-YGSLQPPIYLTALFRQEGEAYPSdrGFDlkYSREENPTLRPLEEALAKLEGGVDALAFNSGMAAIsT 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 84 LAFEIFPVGSKVVAARDLYGGSFRWFNDKEKEG-RFFFEYTNTEDeMIAAITED-TDIVYIETPTNPLMIEFDIEKVAKI 161
Cdd:PRK08574 84 LFFSLLKAGDRVVLPMEAYGTTLRLLKSLEKFGvKVVLAYPSTED-IIEAIKEGrTKLVFIETMTNPTLKVIDVPEVAKA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 162 AHDKGAVVIVDNTFYSPIYQTPITQGADIVVHSATKYLSGHNDVLAGVVVTSNQEFYDKLYYNLNTTGPTLSPFDSYMLM 241
Cdd:PRK08574 163 AKELGAILVVDNTFATPLLYRPLRHGADFVVHSLTKYIAGHNDVVGGVAVAWSGEFLEELWEWRRRLGTIMQPFEAYLVL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 242 RGLKTLKLRMEASTANAQEVVAFLEKSPAVKEVLYPG------------------KGGMISFKV-ANQDKIPTIINSLKV 302
Cdd:PRK08574 243 RGLKTLEVRFERQCRNAMAIAEFLSEHPKVAEVYYPGlpsdpyhgvakrlfgkdlYGGVVSFRVkGGRDAVLKFLRSLKL 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488979160 303 FTFAESLGGVESLITYPTTQTHADIPGDVRASYGLTDDLLRLSIGIEAAQDLIADLENALS 363
Cdd:PRK08574 323 IKPSPSLGGVESLATYPVKSAASPIPEEDRKALGITEDLVRLSVGLEDVEDLIEDLDQALG 383
|
|
| PRK06234 |
PRK06234 |
methionine gamma-lyase; Provisional |
13-364 |
9.48e-99 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 168478 [Multi-domain] Cd Length: 400 Bit Score: 298.28 E-value: 9.48e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 13 HAGINSDEATGALASPIHFSTTYQHPEF--------GHSTGFDYTRTKNPTRATVEKTLAAIEKADYAIATSSGMSAIVL 84
Cdd:PRK06234 15 HGGHIGDKQFGSLATPIYQTSTFIFDSAeqggrrfaGEESGYIYSRLGNPTSTEVENKLALLEGGEAAVVAASGMGAISS 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 85 A-FEIFPVGSKVVAARDLYGGSFRWFNdkEKEGRF-----FFEYTNTEdEMIAAITEDTDIVYIETPTNPLMIEFDIEKV 158
Cdd:PRK06234 95 SlWSALKAGDHVVASDTLYGCTFALLN--HGLTRYgvevtFVDTSNLE-EVRNALKANTKVVYLETPANPTLKVTDIKAI 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 159 AKIAH--DKGAVVIVDNTFYSPIYQTPITQGADIVVHSATKYLSGHNDVLAGVVVTsNQEFYD--KLYYNLNTTGPTLSP 234
Cdd:PRK06234 172 SNIAHenNKECLVFVDNTFCTPYIQRPLQLGADVVVHSATKYLNGHGDVIAGFVVG-KEEFINqvKLFGIKDMTGSVIGP 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 235 FDSYMLMRGLKTLKLRMEASTANAQEVVAFLEKSPAVKEVLYPG----------------KGGMISFKV-ANQDKIPTII 297
Cdd:PRK06234 251 FEAFLIIRGMKTLQIRMEKHCKNAMKVAKFLESHPAVEKVYYPGlesfeyyelakkqmslPGAMISFELkGGVEEGKVVM 330
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488979160 298 NSLKVFTFAESLGGVESLITYPTTQTHADIPGDVRASYGLTDDLLRLSIGIEAAQDLIADLENALSL 364
Cdd:PRK06234 331 NNVKLATLAVSLGDAETLIQHPASMTHSPYTAEERKEAGISDGLVRLSVGLEDVDDIIADLKQALDL 397
|
|
| cysta_beta_ly_E |
TIGR01329 |
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ... |
7-362 |
3.32e-97 |
|
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.
Pssm-ID: 273557 [Multi-domain] Cd Length: 378 Bit Score: 293.66 E-value: 3.32e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 7 LETILAHAGINSDEaTGALASPIHFSTTYQHPEFGHSTGFDYTRTKNPTRATVEKTLAAIEKADYAIATSSGMSAIVLAF 86
Cdd:TIGR01329 1 LSTLLVNTDNKNDP-YDASSMPIYQTATFKQPLAIENGPYDYTRSGNPTRTALESLLAKLDKADRAFAFSSGMAALDVIT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 87 EIFPVGSKVVAARDLYGGSFRWFNDKEKEGRFFFEYTNTE--DEMIAAITEDTDIVYIETPTNPLMIEFDIEKVAKIAHD 164
Cdd:TIGR01329 80 RLLNNGDEIIAGDDLYGGTDRLLTQVVPRSGVVVVHVDTTdlDKVKAALGPKTKLVLLESPTNPLQKIVDIRKISEMAHA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 165 KGAVVIVDNTFYSPIYQTPITQGADIVVHSATKYLSGHNDVLAGVVVTSNQEFYDKLYYNLNTTGPTLSPFDSYMLMRGL 244
Cdd:TIGR01329 160 QNALVVVDNTMMSPLLCNPLELGADIVYHSATKFLAGHSDVMAGVLAVKGEEIAKKVYFLQNSTGSGLAPFDCWLLLRGI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 245 KTLKLRMEASTANAQEVVAFLEKSPAVKEVLYP----------------GKGGMISFKVANQDKIPTIINSLKVFTFAES 308
Cdd:TIGR01329 240 KTLAIRIEKQQENARAIAMFLSTHPRVKKVRYAglpshpgfhlhfsqakGAGSVLSFETGSVALSKRLVEATKLFSITVS 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 488979160 309 LGGVESLITYPTTQTHADIPGDVRASYGLTDDLLRLSIGIEAAQDLIADLENAL 362
Cdd:TIGR01329 320 FGSVNSLISMPCFMSHASIPAEVREERGLPEDLVRLSVGIEDVDDLISDLDIAF 373
|
|
| PLN02509 |
PLN02509 |
cystathionine beta-lyase |
3-362 |
4.29e-97 |
|
cystathionine beta-lyase
Pssm-ID: 178125 [Multi-domain] Cd Length: 464 Bit Score: 296.17 E-value: 4.29e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 3 QEYQLETILAHAGiNSDEATGALASPIHFSTTYQHPEFGHSTGFDYTRTKNPTRATVEKTLAAIEKADYAIATSSGMSAI 82
Cdd:PLN02509 83 EEASVSTLLVNLD-NKFDPFDAMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAAL 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 83 VLAFEIFPVGSKVVAARDLYGGSFRWFNDKEKEGRFFFEYTNTE--DEMIAAITEDTDIVYIETPTNPLMIEFDIEKVAK 160
Cdd:PLN02509 162 SAVTHLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTnlDEVAAAIGPQTKLVWLESPTNPRQQISDIRKIAE 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 161 IAHDKGAVVIVDNTFYSPIYQTPITQGADIVVHSATKYLSGHNDVLAGVVVTSNQEFYDKLYYNLNTTGPTLSPFDSYML 240
Cdd:PLN02509 242 MAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLC 321
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 241 MRGLKTLKLRMEASTANAQEVVAFLEKSPAVKEVLY------PGK----------GGMISFKVANQDKIPTIINSLKVFT 304
Cdd:PLN02509 322 LRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYaglpdhPGHhlhfsqakgaGSVFSFITGSVALSKHLVETTKYFS 401
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 488979160 305 FAESLGGVESLITYPTTQTHADIPGDVRASYGLTDDLLRLSIGIEAAQDLIADLENAL 362
Cdd:PLN02509 402 IAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAF 459
|
|
| PRK06767 |
PRK06767 |
methionine gamma-lyase; Provisional |
3-362 |
3.10e-96 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 180685 [Multi-domain] Cd Length: 386 Bit Score: 291.36 E-value: 3.10e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 3 QEYQLETILAHAGINSDEATGALASPIHFSTTYQHPEF--------GHSTGFDYTRTKNPTRATVEKTLAAIEKADYAIA 74
Cdd:PRK06767 2 KKKHMETALIHHGYTSEEHKGSLTPPLFQTSTFTFETAqqgeasfaGVDPSYIYSRLGNPTVKLFEERMAVLEGGEEALA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 75 TSSGMSAI-VLAFEIFPVGSKVVAARDLYGGSFRWFNDKEKEGRFFFEYTN--TEDEMIAAITEDTDIVYIETPTNPLMI 151
Cdd:PRK06767 82 FGSGMAAIsATLIGFLKAGDHIICSNGLYGCTYGFLEVLEEKFMITHSFCDmeTEADIENKIRPNTKLIFVETPINPTMK 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 152 EFDIEKVAKIAHDKGAVVIVDNTFYSPIYQTPITQGADIVVHSATKYLSGHNDVLAGVVVTSNQEFYDKLYYNLNTTGPT 231
Cdd:PRK06767 162 LIDLKQVIRVAKRNGLLVIVDNTFCSPYLQRPLELGCDAVVHSATKYIGGHGDVVAGVTICKTRALAEKIRPMRKDIGGI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 232 LSPFDSYMLMRGLKTLKLRMEASTANAQEVVAFLEKSPAVKEVLYPG----------KGGMISFKV-ANQDKIPTIINSL 300
Cdd:PRK06767 242 MAPFDAWLLLRGLKTLAVRMDRHCDNAEKIVSFLKNHDAVEGVWYPEgelasrqmkrGGGVISFSIkGGKEETQAFINDL 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488979160 301 KVFTFAESLGGVESLITYPTTQTHADIPGDVRASYGLTDDLLRLSIGIEAAQDLIADLENAL 362
Cdd:PRK06767 322 HFITIAVSLGDTETLIQHPATMTHAAIPAELRQEMGIYDNLIRLSVGLESWEDIVSDLEQAL 383
|
|
| met_gam_lyase |
TIGR01328 |
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of ... |
8-362 |
5.11e-94 |
|
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of PLP-dependent trans-sulfuration enzymes. The member from the parasite Trichomonas vaginalis is described as catalyzing alpha gamma- and alpha-beta eliminations and gamma-replacement reactions on methionine, cysteine, and some derivatives. Likewise, the enzyme from Pseudomonas degrades cysteine as well as methionine. [Energy metabolism, Amino acids and amines]
Pssm-ID: 130395 [Multi-domain] Cd Length: 391 Bit Score: 286.01 E-value: 5.11e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 8 ETILAHAGINSDEATGALASPIHFSTTYQHPEF--------GHSTGFDYTRTKNPTRATVEKTLAAIEKADYAIATSSGM 79
Cdd:TIGR01328 5 ATRAIHAGYPPKDQFGALTPPIYQTSTFVFDSCeqggnrfaGQESGYIYSRLGNPTVSNLEGRIAFLEGTEAAVATSSGM 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 80 SAI-VLAFEIFPVGSKVVAARDLYGGSFRWFND-KEKEG-RFFFEYTNTEDEMIAAITEDTDIVYIETPTNPLMIEFDIE 156
Cdd:TIGR01328 85 GAIaATLLTILKAGDHLISDECLYGCTFALLEHaLTKFGiQVDFINMAIPEEVKAHIKDNTKIVYFETPANPTMKLIDME 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 157 KVAKIAHDKGAVVIVDNTFYSPIYQTPITQGADIVVHSATKYLSGHNDVLAGVVVTSNQEFYD-KLYYNLNTTGPTLSPF 235
Cdd:TIGR01328 165 RVCRDAHSQGVKVIVDNTFATPMLTNPVALGVDVVVHSATKYIGGHGDVVAGLICGKAELLQQiRMVGIKDMTGSVISPF 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 236 DSYMLMRGLKTLKLRMEASTANAQEVVAFLEKSPAVKEVLYPG----------------KGGMISFKV-ANQDKIPTIIN 298
Cdd:TIGR01328 245 DAWLILRGLKTLNIRMKRHSENAMKVAEYLKSHPAVEKVYYPGfedhpghdiaakqmrmGGGMITFELkGGFAGAKKLLN 324
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488979160 299 SLKVFTFAESLGGVESLITYPTTQTHADIPGDVRASYGLTDDLLRLSIGIEAAQDLIADLENAL 362
Cdd:TIGR01328 325 NLKLIRLAVSLGDAETLIQHPASMTHAVVPKEEREAAGITDGMIRLSVGLEDADDLIADLKQAL 388
|
|
| PRK08133 |
PRK08133 |
O-succinylhomoserine sulfhydrylase; Validated |
1-363 |
5.25e-94 |
|
O-succinylhomoserine sulfhydrylase; Validated
Pssm-ID: 181244 [Multi-domain] Cd Length: 390 Bit Score: 285.74 E-value: 5.25e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 1 MTQEYQLETILAHAGIN-SDEATGA----LASPIHFSTTYQHPE-FGHST-GFDYTRTKNPTRATVEKTLAAIEKADYAI 73
Cdd:PRK08133 1 DDDSLGFDTLAVRAGQLrSPFGEHSealfLTSSFVFESAAEAAArFAGEEpGNIYSRFTNPTVTMFQERLAALEGAEACV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 74 ATSSGMSAIV-LAFEIFPVGSKVVAARDLYGGSFRWFNDKEKegRFFFEYT----NTEDEMIAAITEDTDIVYIETPTNP 148
Cdd:PRK08133 81 ATASGMAAILaVVMALLQAGDHVVSSRSLFGSTVSLFEKIFA--RFGIETTfvdlTDLDAWRAAVRPNTKLFFLETPSNP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 149 LMIEFDIEKVAKIAHDKGAVVIVDNTFYSPIYQTPITQGADIVVHSATKYLSGHNDVLAGVVVTSnQEFYDKLYYNLNTT 228
Cdd:PRK08133 159 LTELADIAALAEIAHAAGALLVVDNCFCTPALQQPLKLGADVVIHSATKYLDGQGRVLGGAVVGS-KELMEEVFGFLRTA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 229 GPTLSPFDSYMLMRGLKTLKLRMEASTANAQEVVAFLEKSPAVKEVLYPG----------------KGGMISFKVAN-QD 291
Cdd:PRK08133 238 GPTLSPFNAWVFLKGLETLSLRMEAHSANALALAEWLEAHPGVERVFYPGlpshpqhelakrqqkgGGAIVSFEVKGgRE 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488979160 292 KIPTIINSLKVFTFAESLGGVESLITYPTTQTHADIPGDVRASYGLTDDLLRLSIGIEAAQDLIADLENALS 363
Cdd:PRK08133 318 AAWRVIDATRLISITANLGDTKTTITHPATTTHGRLSPEARAAAGITEGLIRVAVGLEDVADIKADLARGLA 389
|
|
| PRK06460 |
PRK06460 |
hypothetical protein; Provisional |
19-363 |
5.27e-92 |
|
hypothetical protein; Provisional
Pssm-ID: 235807 [Multi-domain] Cd Length: 376 Bit Score: 280.18 E-value: 5.27e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 19 DEATGALASPIHFSTTYQHPEfghSTGFDYTRTKNPTRATVEKTLAAIEKADYAIATSSGMSAI-VLAFEIFPVGSKVVA 97
Cdd:PRK06460 13 DEATGAITTPIYQTTAYHYPE---GEKYRYSREANPTVLELTKKIVELENAEMGVAFSSGMGAIsTTALALLKPGNSVLV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 98 ARDLYGGSFRWFNDKEKEGRFFFEYTNTEDEMI--AAITEDTDIVYIETPTNPLMIEFDIEKVAKIAHDKGAVVIVDNTF 175
Cdd:PRK06460 90 HRDMFGRSYRFFTDYLKNWGVNVDASNPGSDNIieKAKSKRYDVVFVENITNPLLRVVDITELSKVCKENGSILIVDATF 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 176 YSPIYQTPITQGADIVVHSATKYLSGHNDVLAGVVVTSNqEFYDKLYYNLNTTGPTLSPFDSYMLMRGLKTLKLRMEAST 255
Cdd:PRK06460 170 STPINQKPLELGADIVVHSASKFLAGHNDVIAGLAAGYG-KLLNVIDQMRRTLGTSLDPHAAYLTLRGIKTLKIRMDVIN 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 256 ANAQEVVAFLEKSPAVKEVLYPG----------------KGGMISFKV-ANQDKIPTIINSLKVFTFAESLGGVESLITY 318
Cdd:PRK06460 249 RNAEQIAEFLEGHPKVVKVYYPGlkshvdyeiarrvlkgFGGVLSFEVnGGQESALKVMKSLKLIIPAQTLGGVNSVISH 328
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 488979160 319 PTTQTHADIPGDVRASYGLTDDLLRLSIGIEAAQDLIADLENALS 363
Cdd:PRK06460 329 PATMSHRTLSLEERKIVGITDSLLRLSVGIEDVNDLIEDLDRALS 373
|
|
| PRK07503 |
PRK07503 |
methionine gamma-lyase; Provisional |
13-363 |
1.57e-91 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 181005 [Multi-domain] Cd Length: 403 Bit Score: 279.76 E-value: 1.57e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 13 HAGINSDEATGALASPIHFSTTYQHPEF--------GHSTGFDYTRTKNPTRATVEKTLAAIEKADYAIATSSGMSAIVL 84
Cdd:PRK07503 16 HHGYDPLDHGGALVPPVYLTATFAFPTAeygaecfaGEEEGHFYSRISNPTLALLEQRMASLEGGEAAVALASGMGAITA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 85 AF-EIFPVGSKVVAARDLYGGSFRWFNDKEkeGRFFFEYTNTE----DEMIAAITEDTDIVYIETPTNPLMIEFDIEKVA 159
Cdd:PRK07503 96 TLwTLLRPGDEVIVDQTLYGCTFAFLHHGL--GEFGVTVRHVDltdpAALKAAISDKTRMVYFETPANPNMRLVDIAAVA 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 160 KIAHDKGAVVIVDNTFYSPIYQTPITQGADIVVHSATKYLSGHNDVLAGVVVTSNQEFYD-KLYYNLNTTGPTLSPFDSY 238
Cdd:PRK07503 174 EIAHGAGAKVVVDNTYCTPYLQRPLELGADLVVHSATKYLGGHGDITAGLVVGGKALADRiRLEGLKDMTGAVMSPFDAF 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 239 MLMRGLKTLKLRMEASTANAQEVVAFLEKSPAVKEVLYPG----------------KGGMISFKV-ANQDKIPTIINSLK 301
Cdd:PRK07503 254 LLMRGLKTLALRMDRHCASAQAVAEWLARHPAVELVHYPGlpsfaqhalaqrqmalPGGMIAFELkGGIAAGRRFMNALQ 333
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488979160 302 VFTFAESLGGVESLITYPTTQTHADIPGDVRASYGLTDDLLRLSIGIEAAQDLIADLENALS 363
Cdd:PRK07503 334 LFARAVSLGDAESLAQHPASMTHSTYTPEERAEHGISEGLVRLSVGLEDVADILADLAQALD 395
|
|
| PRK08249 |
PRK08249 |
cystathionine gamma-synthase family protein; |
14-362 |
3.89e-90 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236202 [Multi-domain] Cd Length: 398 Bit Score: 276.24 E-value: 3.89e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 14 AGINSDEATGALASPIHFSTTYQHPE--------FGHSTGFDYTRTKNPTRATVEKTLAAIEKADYAIATSSGMSAI--V 83
Cdd:PRK08249 16 AGEKEYLPYGATQVPVVLSVAYGYDDidewydvaLGKKPGHIYSRNTNPTVQAFEEKVRILEGAEAATAFSTGMAAIsnT 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 84 LAFEIFPvGSKVVAARDLYGGSFRWFNDkekegrFFFEY--------TNTEDEMIAAITEDTDIVYIETPTNPLMIEFDI 155
Cdd:PRK08249 96 LYTFLKP-GDRVVSIKDTYGGTNKIFTE------FLPRMgvdvtlceTGDHEQIEAEIAKGCDLLYLETPTNPTLKIVDI 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 156 EKVAKIAHDKGAVVIVDNTFYSPIYQTPITQGADIVVHSATKYLSGHNDVLAGVVVTSnQEFYDKLYYNLNTTGPTLSPF 235
Cdd:PRK08249 169 ERLAAAAKKVGALVVVDNTFATPINQNPLALGADLVIHSATKFLSGHADALGGVVCGS-KELMEQVYHYREINGATMDPM 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 236 DSYMLMRGLKTLKLRMEASTANAQEVVAFLEKSPAVKEVLYPGK----------------GGMISFKVANQ-DKIPTIIN 298
Cdd:PRK08249 248 SAYLILRGMKTLKLRVRQQQESAMALAKYLQTHPKVEAVYYPGLethpnheiakaqmrgfGGILSFVLKGGmDTVKRLLP 327
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488979160 299 SLKVFTFAESLGGVESLITYPTTQTHADIPGDVRASYGLTDDLLRLSIGIEAAQDLIADLENAL 362
Cdd:PRK08249 328 KLRYAHRAANLGAVETIYGPARTTSHVENTLEERAALGIPEGLVRISVGIEDTEDLIADLEQAF 391
|
|
| OAH_OAS_sulfhy |
TIGR01326 |
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism ... |
7-362 |
2.93e-89 |
|
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism pyridoxal phosphate-dependent enzyme superfamily. Members include examples of OAH/OAS sulfhydrylase, an enzyme with activity both as O-acetylhomoserine (OAH) sulfhydrylase (EC 2.5.1.49) and O-acetylserine (OAS) sulphydrylase (EC 2.5.1.47). An alternate name for OAH sulfhydrylase is homocysteine synthase. This model is designated subfamily because it may or may not have both activities. [Amino acid biosynthesis, Aspartate family, Amino acid biosynthesis, Serine family]
Pssm-ID: 273555 [Multi-domain] Cd Length: 418 Bit Score: 274.62 E-value: 2.93e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 7 LETILAHAGINSDEATGALASPIHFSTTYQHPEFGHS--------TGFDYTRTKNPTRATVEKTLAAIEKADYAIATSSG 78
Cdd:TIGR01326 2 FETLQLHAGQEPDPTTGSRAVPIYQTTSYVFDSTEHAaalfglqePGNIYSRLMNPTTDVLEQRIAALEGGVAALAVASG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 79 MSAIVLAF-EIFPVGSKVVAARDLYGGSFRWFNDKEK----EGRFFFEytNTEDEMIAAITEDTDIVYIETPTNPLMIEF 153
Cdd:TIGR01326 82 QAAITYAIlNLAGAGDNIVSSSYLYGGTYNLFSHTLKrlgiEVRFVDP--DDPESLEKAIDENTKAVFAETIGNPQINVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 154 DIEKVAKIAHDKGAVVIVDNTFYSPIYQTPITQGADIVVHSATKYLSGHNDVLAGVVVTS------NQEF---------Y 218
Cdd:TIGR01326 160 DIEAIAEVAHRHGIPLIVDNTFATPYLCRPIKHGADIVVHSATKYIGGHGTAIGGVIVDGgkfdwnNGRFplfttpdpsY 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 219 DKLYYN----------------LNTTGPTLSPFDSYMLMRGLKTLKLRMEASTANAQEVVAFLEKSPAVKEVLYPG---- 278
Cdd:TIGR01326 240 HGLVFTetlgnpafilkarvqlLRDLGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLESHPDVAWVNYPGlash 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 279 -------------KGGMISFKVAN-QDKIPTIINSLKVFTFAESLGGVESLITYPTTQTHADIPGDVRASYGLTDDLLRL 344
Cdd:TIGR01326 320 phhalakkylpkgFGAVLSFEIKGgREAGKKFIDALKLASHLANVGDAKSLVIHPASTTHSQLSEEEQLKAGVTPGLIRL 399
|
410
....*....|....*...
gi 488979160 345 SIGIEAAQDLIADLENAL 362
Cdd:TIGR01326 400 SVGIENIDDIIADLEQAL 417
|
|
| PRK06434 |
PRK06434 |
cystathionine gamma-lyase; Validated |
13-363 |
3.61e-87 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 102374 [Multi-domain] Cd Length: 384 Bit Score: 268.31 E-value: 3.61e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 13 HAGINSDEATGALASPIHFSTTYQHPE------FGHSTG--FDYTRTKNPTRATVEKTLAAIEKADYAIATSSGMSAIVL 84
Cdd:PRK06434 15 QSGELRDPRFGNVTTPIFETSTFVYPNsekeayMDSTRGmpYIYTRWGNPTVQAFEEKYAVLENAEHALSFSSGMGAITS 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 85 A-FEIFPVGSKVVAARDLYGGSFRWFNDKEKEGRFFFEYTNTED-EMIAAITEDTDIVYIETPTNPLMIEFDIEKVAKIA 162
Cdd:PRK06434 95 AiLSLIKKGKRILSISDLYGQTFYFFNKVLKTLGIHVDYIDTDRlNSLDFDPSNYDLIYAESITNPTLKVPDIKNVSSFC 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 163 HDKgaVVIVDNTFYSPIYQTPITQGADIVVHSATKYLSGHNDVLAGVVVTSNQEFYDKLYYNLNTTGPTLSPFDSYMLMR 242
Cdd:PRK06434 175 HEN--DVIVDATFASPYNQNPLDLGADVVIHSATKYISGHSDVVMGVAGTNNKSIFNNLVERRKTLGSNPDPIQAYLALR 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 243 GLKTLKLRMEASTANAQEVVAFLEKSPAVKEVLYP----------GKGGMISFKVANQDKIPTIINSLKVFTFAESLGGV 312
Cdd:PRK06434 253 GLKTLGLRMEKHNKNGMELARFLRDSKKISNVYYPdteigkkvlrGFGGMLSFELRSMEDVHKFIRNLEIPMVAASLGGV 332
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 488979160 313 ESLITYPTTQTHADIPGDVRASYGLTDDLLRLSIGIEAAQDLIADLENALS 363
Cdd:PRK06434 333 ESLITLPVETSHSSLSPEERERLGISDNLVRFSIGIEDIDDLIKDIENALS 383
|
|
| PRK07810 |
PRK07810 |
O-succinylhomoserine sulfhydrylase; Provisional |
46-363 |
2.50e-79 |
|
O-succinylhomoserine sulfhydrylase; Provisional
Pssm-ID: 236103 [Multi-domain] Cd Length: 403 Bit Score: 248.50 E-value: 2.50e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 46 FDYTRTKNPTRATVEKTLAAIEKADYAIATSSGMSAIVLAF-EIFPVGSKVVAARDLYGGSFRWFNdkEKEGRFFFE--Y 122
Cdd:PRK07810 62 FVYSRYGNPTVSMFEERLRLIEGAEACFATASGMSAVFTALgALLGAGDRLVAARSLFGSCFVVCN--EILPRWGVEtvF 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 123 TNTED--EMIAAITEDTDIVYIETPTNPLMIEFDIEKVAKIAHDKGAVVIVDNTFYSPIYQTPITQGADIVVHSATKYLS 200
Cdd:PRK07810 140 VDGEDlsQWEEALSVPTQAVFFETPSNPMQSLVDIAAVSELAHAAGAKVVLDNVFATPLLQRGLPLGADVVVYSGTKHID 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 201 GHNDVLAGVVVTSnQEFYDKLYYNL-NTTGPTLSPFDSYMLMRGLKTLKLRMEASTANAQEVVAFLEKSPAVKEVLYP-- 277
Cdd:PRK07810 220 GQGRVLGGAILGD-REYIDGPVQKLmRHTGPALSAFNAWVLLKGLETLALRVRHSNASALRIAEFLEGHPAVRWVRYPfl 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 278 --------------GKGGMISFK-----VANQDKIPTIINSLKVFTFAESLGGVESLITYPTTQTHADIPGDVRASYGLT 338
Cdd:PRK07810 299 pshpqydlakrqmsGGGTVVTFEldapeDAAKKRAFEVLDKLRVIDISNNLGDAKSLITHPATTTHRAMGPEGRAAIGLG 378
|
330 340
....*....|....*....|....*
gi 488979160 339 DDLLRLSIGIEAAQDLIADLENALS 363
Cdd:PRK07810 379 DGVVRLSVGLEDTDDLIADLDRALG 403
|
|
| PRK07504 |
PRK07504 |
O-succinylhomoserine sulfhydrylase; Reviewed |
1-362 |
2.06e-76 |
|
O-succinylhomoserine sulfhydrylase; Reviewed
Pssm-ID: 168979 [Multi-domain] Cd Length: 398 Bit Score: 240.81 E-value: 2.06e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 1 MTQEYQLETILAHAG-INSDEATGALASPIHFSTTYQHPE-----F-GHSTGFDYTRTKNPTRATVEKTLAAIEKADYAI 73
Cdd:PRK07504 5 MARKWRPATRLVHSGtLRSQFGETSEALFLTQGFVYDTAEaaearFkGEDPGFIYSRYSNPTVDMFEKRMCALEGAEDAR 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 74 ATSSGMSAIVLAFeIFPV--GSKVVAARDLYGgSFRWFNDkEKEGRFFFEYTNTE----DEMIAAITEDTDIVYIETPTN 147
Cdd:PRK07504 85 ATASGMAAVTAAI-LCQVkaGDHVVAARALFG-SCRYVVE-TLLPRYGIESTLVDgldlDNWEKAVRPNTKVFFLESPTN 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 148 PLMIEFDIEKVAKIAHDKGAVVIVDNTFYSPIYQTPITQGADIVVHSATKYLSGHNDVLAGVVVTSNQEFYDKLYYNLNT 227
Cdd:PRK07504 162 PTLEVIDIAAVAKIANQAGAKLVVDNVFATPLFQKPLELGAHIVVYSATKHIDGQGRCLGGVVLSDKAWIEEHLQDYFRH 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 228 TGPTLSPFDSYMLMRGLKTLKLRMEASTANAQEVVAFLEKSPAVKEVLYPG--------------KGG--MISFKV-ANQ 290
Cdd:PRK07504 242 TGPSLSPFNAWTLLKGLETLPVRVRQQTESAAAIADFLAGHPKVARVIYPGradhpqadiiakqmTGGstLVAFELkGGK 321
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488979160 291 DKIPTIINSLKVFTFAESLGGVESLITYPTTQTHADIPGDVRASYGLTDDLLRLSIGIEAAQDLIADLENAL 362
Cdd:PRK07504 322 EAAFRFLNALKIVRISNNLGDAKSLITHPATTTHKNLSPEARAELGISEGFLRLSAGLEDTDDLIEDLAAAL 393
|
|
| PRK08134 |
PRK08134 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
8-362 |
3.64e-76 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236159 Cd Length: 433 Bit Score: 241.18 E-value: 3.64e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 8 ETILAHAGINSDEATGALASPIHFSTTYQHPEFGHST--------GFDYTRTKNPTRATVEKTLAAIEKADYAIATSSGM 79
Cdd:PRK08134 10 DTLALHAGAAPDPATGARAVPIHLTTSFVFRDSDHAAalfnleraGHVYSRISNPTVAVLEERVAALEGGVGAIATASGQ 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 80 SAIVLAF-EIFPVGSKVVAARDLYGGSFRWFNDKEKegRFFFEYTNTE----DEMIAAITEDTDIVYIETPTNPLMIEFD 154
Cdd:PRK08134 90 AALHLAIaTLMGAGSHIVASSALYGGSHNLLHYTLR--RFGIETTFVKpgdiDGWRAAIRPNTRLLFGETLGNPGLEVLD 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 155 IEKVAKIAHDKGAVVIVDNTFYSPIYQTPITQGADIVVHSATKYLSGHNDVLAGVVVTSNQ-------------EFYDKl 221
Cdd:PRK08134 168 IPTVAAIAHEAGVPLLVDSTFTTPYLLRPFEHGADLVYHSATKFLGGHGTAIGGVLVDGGRfdweasgkfpeltEPYAG- 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 222 YYN--------------------LNTTGPTLSPFDSYMLMRGLKTLKLRMEASTANAQEVVAFLEKSPAVKEVLYP---- 277
Cdd:PRK08134 247 FHGmvfaeestvaafllrarregLRDFGACLSPMNAWQLLQGIETLPLRMERHVANTRKVVAFLASHPAVARVAHPeles 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 278 -------------GKGGMISFKV-ANQDKIPTIINSLKVFTFAESLGGVESLITYPTTQTHADIPGDVRASYGLTDDLLR 343
Cdd:PRK08134 327 hpdhalakrllprGAGSVFSFDLkGGRAAGRKFIESLKLFSHLANVGDARSLVIHPASTTHFRMDAAALAAAGIGEGTIR 406
|
410
....*....|....*....
gi 488979160 344 LSIGIEAAQDLIADLENAL 362
Cdd:PRK08134 407 LSIGLEDADDLIDDLKRAL 425
|
|
| PRK07812 |
PRK07812 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
1-359 |
6.29e-75 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236105 Cd Length: 436 Bit Score: 238.11 E-value: 6.29e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 1 MTQEYQLETILAHAGINSDEATGALASPIHFSTTY-----QHPE--FGHS-TGFDYTRTKNPTRATVEKTLAAIEKADYA 72
Cdd:PRK07812 8 PTANWSFETKQIHAGQTPDPATNARALPIYQTTSYtfddtDHAAalFGLAePGNIYTRIMNPTQDVVEQRIAALEGGVAA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 73 IATSSGMSAIVLA-FEIFPVGSKVVAARDLYGGSFRWFndKEKEGRFFFEYTNTED-----EMIAAITEDTDIVYIETPT 146
Cdd:PRK07812 88 LLLASGQAAETFAiLNLAGAGDHIVSSPRLYGGTYNLF--HYTLPKLGIEVSFVEDpddldAWRAAVRPNTKAFFAETIS 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 147 NPLMIEFDIEKVAKIAHDKGAVVIVDNTFYSPIYQTPITQGADIVVHSATKYLSGHNDVLAGVVV--------------- 211
Cdd:PRK07812 166 NPQIDVLDIPGVAEVAHEAGVPLIVDNTIATPYLIRPLEHGADIVVHSATKYLGGHGTAIAGVIVdggtfdwtqgrfpgf 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 212 TSNQEFYDKLYYN---------------LNTTGPTLSPFDSYMLMRGLKTLKLRMEASTANAQEVVAFLEKSPAVKEVLY 276
Cdd:PRK07812 246 TTPDPSYHGVVFAelgppayalkarvqlLRDLGSAISPFNAFLIAQGLETLSLRIERHVANAQRVAEFLEARDEVASVNY 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 277 P-----------------GKGGMISFKVANQ-DKIPTIINSLKVFTFAESLGGVESLITYPTTQTHADIPGDVRASYGLT 338
Cdd:PRK07812 326 AglpsspwyerakrlapkGTGAVLSFELAGGvEAGKAFVNALTLHSHVANIGDVRSLVIHPASTTHSQLTPEEQLATGVT 405
|
410 420
....*....|....*....|.
gi 488979160 339 DDLLRLSIGIEAAQDLIADLE 359
Cdd:PRK07812 406 PGLVRLAVGIEGIDDILADLE 426
|
|
| PRK05994 |
PRK05994 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
7-363 |
1.29e-73 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 180344 [Multi-domain] Cd Length: 427 Bit Score: 234.61 E-value: 1.29e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 7 LETILAHAGINSDEATGALASPIHFSTTYQHPEFGHST--------GFDYTRTKNPTRATVEKTLAAIEKADYAIATSSG 78
Cdd:PRK05994 8 FATLAVHAGAQPDPTTGARATPIYQTTSFVFNDADHAAslfglqafGNIYTRITNPTNAVLEERVAALEGGTAALAVASG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 79 MSAIVLAFE-IFPVGSKVVAARDLYGGSFRWFNDKEKEGRFFFEYTNTED--EMIAAITEDTDIVYIETPTNPLMIEFDI 155
Cdd:PRK05994 88 HAAQFLVFHtLLQPGDEFIAARKLYGGSINQFGHAFKSFGWQVRWADADDpaSFERAITPRTKAIFIESIANPGGTVTDI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 156 EKVAKIAHDKGAVVIVDNTFYSPIYQTPITQGADIVVHSATKYLSGHNDVLAGVVVT------SNQEFYDKLY-----YN 224
Cdd:PRK05994 168 AAIAEVAHRAGLPLIVDNTLASPYLIRPIEHGADIVVHSLTKFLGGHGNSMGGIIVDggtfdwSKSGKYPMLSeprpeYH 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 225 ---------------------LNTTGPTLSPFDSYMLMRGLKTLKLRMEASTANAQEVVAFLEKSPAVKEVLYPG----- 278
Cdd:PRK05994 248 glvlhetfgnfafaiaarvlgLRDLGPAISPFNAFLILTGIETLPLRMQRHSDNALAVAEWLKGHPKVSWVNYAGlpddp 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 279 ------------KGGMISFKVAN-QDKIPTIINSLKVFTFAESLGGVESLITYPTTQTHADIPGDVRASYGLTDDLLRLS 345
Cdd:PRK05994 328 yhalaqkyspkgAGAVFTFGLKGgYEAGVKLVSSLKLFSHLANIGDTRSLVIHPASTTHRQLTDEQKVAAGAGPDVVRLS 407
|
410
....*....|....*...
gi 488979160 346 IGIEAAQDLIADLENALS 363
Cdd:PRK05994 408 IGIEDVDDIIADLEQALA 425
|
|
| PRK08248 |
PRK08248 |
homocysteine synthase; |
3-362 |
6.42e-73 |
|
homocysteine synthase;
Pssm-ID: 236201 [Multi-domain] Cd Length: 431 Bit Score: 232.81 E-value: 6.42e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 3 QEYQLETILAHAGINSDEATGALASPIHFSTTYQHPEFGHST--------GFDYTRTKNPTRATVEKTLAAIEKADYAIA 74
Cdd:PRK08248 5 RTFRLETLAIHAGQEIDPTTGSRAVPIYQTTSYGFRDSEHAAnlfslkefGNIYTRIMNPTTDVFEKRIAALEGGIGALA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 75 TSSGMSAIVLA-FEIFPVGSKVVAARDLYGGSFRWF-NDKEKEG--RFFFEYTNTEdEMIAAITEDTDIVYIETPTNPLM 150
Cdd:PRK08248 85 VSSGQAAITYSiLNIASAGDEIVSSSSLYGGTYNLFaHTLPKLGitVKFVDPSDPE-NFEAAITDKTKALFAETIGNPKG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 151 IEFDIEKVAKIAHDKGAVVIVDNTFYSPIYQTPITQGADIVVHSATKYLSGHNDVLAGVVV----------------TSN 214
Cdd:PRK08248 164 DVLDIEAVAAIAHEHGIPLIVDNTFASPYLLRPIEHGADIVVHSATKFIGGHGTSIGGVIVdsgkfdwkgsgkfpglTEP 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 215 QEFYDKLYYN----------------LNTTGPTLSPFDSYMLMRGLKTLKLRMEASTANAQEVVAFLEKSPAVKEVLYPG 278
Cdd:PRK08248 244 DPSYHGLVYTdavgeaayitkarvqlLRDLGAALSPFNSFLLLQGLETLHLRMERHSENALAVAKFLEEHEAVEWVSYPG 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 279 KGGMISFKVAN------QDKIPT------------IINSLKVFTFAESLGGVESLITYPTTQTHADIPGDVRASYGLTDD 340
Cdd:PRK08248 324 LPSHPSYELAKkylpkgQGAILTfgikggveagkkLIDSVKLFSHLANVGDSKSLIIHPASTTHQQLSEEEQLAAGVTPG 403
|
410 420
....*....|....*....|..
gi 488979160 341 LLRLSIGIEAAQDLIADLENAL 362
Cdd:PRK08248 404 LVRLSVGTEAIDDILDDLRQAI 425
|
|
| PRK05968 |
PRK05968 |
hypothetical protein; Provisional |
6-363 |
3.75e-71 |
|
hypothetical protein; Provisional
Pssm-ID: 168320 [Multi-domain] Cd Length: 389 Bit Score: 226.89 E-value: 3.75e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 6 QLETILAHAGINsdeATGALASPIHFSTTYQHPEF--------GHSTGFDYTRTKNPTRATVEKTLAAIEKADYAIATSS 77
Cdd:PRK05968 10 LAALITAHDEGN---AFDAVVPPIFQTSLFTFDSYdemedvyaGEKVRPIYSRGDNPTVRAFEEMLAKLEGAEDARGFAS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 78 GMSAI---VLAFeIFPvGSKVVAARDLYGGSFRWFNDKEKEGRFFFEYTN-TEDEMIAAITEDTDIVYIETPTNPLMIEF 153
Cdd:PRK05968 87 GMAAIsstVLSF-VEP-GDRIVAVRHVYPDAFRLFETILKRMGVEVDYVDgRDEEAVAKALPGAKLLYLESPTSWVFELQ 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 154 DIEKVAKIAHDKGAVVIVDNTFYSPIYQTPITQGADIVVHSATKYLSGHNDVLAGVVVTS-------NQEFYDKLyynln 226
Cdd:PRK05968 165 DVAALAALAKRHGVVTMIDNSWASPVFQRPITLGVDLVIHSASKYLGGHSDTVAGVVAGSkehiariNAEAYPYL----- 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 227 ttGPTLSPFDSYMLMRGLKTLKLRMEASTANAQEVVAFLEKSPAVKEVLYP-----------GKGGMISFKVANQDKIPT 295
Cdd:PRK05968 240 --GAKLSPFEAWLLLRGLRTLPLRMKAHEASALEIARRLKAHPVVERVCHPalanhppaglsGTSGLFSFIFREGIDVRA 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488979160 296 IINSLKVFTFAESLGGVESLItypttqthadIPGDVR----------ASYGLTDDLLRLSIGIEAAQDLIADLENALS 363
Cdd:PRK05968 318 FADALKLFRLGVSWGGHESLV----------VPAEVVlqqkaqpnsaARFGVSPRSVRLHVGLEGTEALWADLEQALA 385
|
|
| PRK07049 |
PRK07049 |
cystathionine gamma-synthase family protein; |
4-362 |
1.86e-70 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 180809 [Multi-domain] Cd Length: 427 Bit Score: 226.48 E-value: 1.86e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 4 EYQLETILAHAGINSDEATGALASPIHFSTTY------------------QHPEFGHSTGFDYTRTKNPTRATVEKTLAA 65
Cdd:PRK07049 15 ELHPETQMLNYGYDPELSEGAVKPPVFLTSTFvfrsaedgrdffdyvsgrKEPPAGEGAGLVYSRFNHPNSEIVEDRLAV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 66 IEKADYAIATSSGMSAI---VLAFeIFPvGSKVVAARDLYGGSfrwfndkekE---GRFF---------FEYTNTEDEMI 130
Cdd:PRK07049 95 YEGAESAALFSSGMSAIattLLAF-VRP-GDVILHSQPLYGGT---------EtllAKTFrnfgvgavgFADGLSEAAIG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 131 AAITE-----DTDIVYIETPTNPLMIEFDIEKVAKIA------HDKGAVVIVDNTFYSPIYQTPITQGADIVVHSATKYL 199
Cdd:PRK07049 164 AAAEAaaakgRVSLILIETPANPTNSLVDVAAVRRVAdaiearQGHRPIIACDNTLLGPVFQKPLEHGADLSVYSLTKYV 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 200 SGHNDVLAGVVvTSNQEFYDKLYYNLNTTGPTLSPFDSYMLMRGLKTLKLRMEASTANAQEVVAFLEKSPAVKEVLYP-- 277
Cdd:PRK07049 244 GGHSDLVAGAV-LGRKALIRQVRALRSAIGTQLDPHSCWMLGRSLETLVLRMERANRNARAVAEFLRDHPKVEKLHYLpf 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 278 ----------------GKGGMISFKVAN-QDKIPTIINSLKVFTFAESLGGVESLITYPTTQTHADIPGDVRASYGLTDD 340
Cdd:PRK07049 323 ldpdsaygavykrqctGAGSTFSFDIKGgQAAAFRFLNALQIFKLAVSLGGTESLASHPASMTHSGVPADVRERIGVLES 402
|
410 420
....*....|....*....|..
gi 488979160 341 LLRLSIGIEAAQDLIADLENAL 362
Cdd:PRK07049 403 TIRLSIGIEHPDDLIADLAQAL 424
|
|
| PRK07582 |
PRK07582 |
cystathionine gamma-lyase; Validated |
9-363 |
2.31e-67 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 236061 Cd Length: 366 Bit Score: 216.40 E-value: 2.31e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 9 TILAHAGINSDEATGALASPIHFSTTYqHPEFGHSTGFD-YTRTKNPTRATVEKTLAAIEKADyAIATSSGMSAI--VLa 85
Cdd:PRK07582 6 TRSVHAGGPEAVPGEPVLPGPVFAAPY-HLSPGEPTGPDtYGRASNPTWRALEAALGELEGAE-ALVFPSGMAAItaVL- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 86 FEIFPVGSKVVAARDLYGgSFRWFNDKEKEGRFFFEYTNTEDEMIAAITEDTDIVYIETPTNPLMIEFDIEKVAKIAHDK 165
Cdd:PRK07582 83 RALLRPGDTVVVPADGYY-QVRALAREYLAPLGVTVREAPTAGMAEAALAGADLVLAETPSNPGLDVCDLAALAAAAHAA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 166 GAVVIVDNTFYSPIYQTPITQGADIVVHSATKYLSGHNDVLAGVVVTSNQEFYDKLYYNLNTTGPTLSPFDSYMLMRGLK 245
Cdd:PRK07582 162 GALLVVDNTTATPLGQRPLELGADLVVASDTKALTGHSDLLLGYVAGRDPELMAAVERWRLLAGAIPGPFEAWLAHRSLG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 246 TLKLRMEASTANAQEVVAFLEKSPAVKEVLYPGK----------------GGMISFKVANQDKIPTIINSLKVFTFAESL 309
Cdd:PRK07582 242 TLGLRFARQCANALAVAELLAGHPAVRGVRYPGLpgdpahevaarqmrrfGGLVSFELADAAAAERFVAASRLVVAATSF 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 488979160 310 GGVESLItypttqthadipgDVRASYG--LTDDLLRLSIGIEAAQDLIADLENALS 363
Cdd:PRK07582 322 GGVHTSA-------------DRRARWGdaVPEGFVRLSCGIEDTDDLVADLERALD 364
|
|
| PRK06084 |
PRK06084 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
6-363 |
1.16e-64 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 180392 [Multi-domain] Cd Length: 425 Bit Score: 211.30 E-value: 1.16e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 6 QLETILAHAGINSDEATGALASPIHFSTTYQHPEFGHSTG-FD-------YTRTKNPTRATVEKTLAAIEKADYAIATSS 77
Cdd:PRK06084 2 KLETLAIHAGYSPDPTTKAVAVPIYQTTSYAFDDTQHGADlFDlkvpgniYTRIMNPTNDVLEQRVAALEGGVGALAVAS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 78 GMSAIVLAFE-IFPVGSKVVAARDLYGGSFRWFndKEKEGRFFFEYTNTEDEMIAA----ITEDTDIVYIETPTNPLMIE 152
Cdd:PRK06084 82 GMAAITYAIQtIAEAGDNIVSVAKLYGGTYNLL--AHTLPRIGIETRFAAHDDIAAlealIDERTKAVFCESIGNPAGNI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 153 FDIEKVAKIAHDKGAVVIVDNTFYSPIYQTPITQGADIVVHSATKYLSGHNDVLAGVVVTS-------NQEFY------D 219
Cdd:PRK06084 160 IDIQALADAAHRHGVPLIVDNTVATPVLCRPFEHGADIVVHSLTKYIGGHGTSIGGIVVDSgkfpwaeHKERFallntpD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 220 KLYYNLN--------------------TTGPTLSPFDSYMLMRGLKTLKLRMEASTANAQEVVAFLEKSPAVKEVLYPG- 278
Cdd:PRK06084 240 PSYHGVTyteafgpaafigrcrvvplrNMGAALSPFNAFLILQGLETLALRMERHTENALKVARYLQQHPQVAWVKYAGl 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 279 ----------------KGGMISFKV-ANQDKIPTIINSLKVFTFAESLGGVESLITYPTTQTHADIPGDVRASYGLTDDL 341
Cdd:PRK06084 320 pdhpehelarrymggkPASILSFGIkGGQAAGARFIDALKLVVRLVNIGDAKSLACHPASTTHRQLNDEELEKAGVSRDM 399
|
410 420
....*....|....*....|..
gi 488979160 342 LRLSIGIEAAQDLIADLENALS 363
Cdd:PRK06084 400 VRLSIGIEHIDDIIADLAQALD 421
|
|
| PRK05613 |
PRK05613 |
O-acetylhomoserine/O-acetylserine sulfhydrylase; |
4-363 |
9.79e-52 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase;
Pssm-ID: 168128 [Multi-domain] Cd Length: 437 Bit Score: 177.76 E-value: 9.79e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 4 EYQLETILAHAGINSDEATGALASPIHFSTTYQHPEFGHST--------GFDYTRTKNPTRATVEKTLAAIEKADYAIAT 75
Cdd:PRK05613 11 QWGFETRSIHAGQSVDSDTSARNLPIYQTTSYVFDSAEHAKqrfaledlGPIYSRLTNPTVEALENRIASLEGGVHAVAF 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 76 SSGMSAIVLAF-EIFPVGSKVVAARDLYGGSFRWFNDKEKegRFFFEYTNTED-----EMIAAITEDTDIVYIETPTNPL 149
Cdd:PRK05613 91 ASGQAAETAAIlNLAGAGDHIVTSPRLYGGTETLFLVTLN--RLGIEVTFVENpddpeSWQAAVQPNTKAFFGETFANPQ 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 150 MIEFDIEKVAKIAHDKGAVVIVDNTFYSPIYQTPITQGADIVVHSATKYLSGHNDVLAGVV------------------- 210
Cdd:PRK05613 169 ADVLDIPAVAEVAHRNQVPLIVDNTIATAALVRPLELGADVVVASLTKFYTGNGSGLGGVLidggkfdwtverdgkpvfp 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 211 --VTSNQEFYDKLYYNLNT--------------TGPTLSPFDSYMLMRGLKTLKLRMEASTANAQEVVAFLEKSPAVKEV 274
Cdd:PRK05613 249 yfVTPDPAYHGLKYADLGApafglkaragllrdTGATLSPFNAWVTAQGLDTLSLRLERHNENAIKVAEFLNNHEKVAKV 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 275 LYPG-----------------KGGMISFKVAN-QDKIPTIINSLKVFTFAESLGGVESLITYPTTQTHADIPGDVRASYG 336
Cdd:PRK05613 329 NFAGlkdspwyatkeklglkyTGSVLSFDIKGgKDEAWAFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDEAGLARAG 408
|
410 420
....*....|....*....|....*..
gi 488979160 337 LTDDLLRLSIGIEAAQDLIADLENALS 363
Cdd:PRK05613 409 ITQATVRLSVGIEDIDDIIADLEGGFA 435
|
|
| PRK05939 |
PRK05939 |
cystathionine gamma-synthase family protein; |
23-364 |
2.91e-51 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 235650 [Multi-domain] Cd Length: 397 Bit Score: 175.65 E-value: 2.91e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 23 GALASPIHFSTTYQHPEF--------GHSTGFDYTRTKNPTRATVEKTLAAIEKADYAIATSSGMSAIVLAFE-IFPVGS 93
Cdd:PRK05939 8 GAVHKPIHTSVTYGYEDArdlidvfqGKKPGFTYARQGTPTTAALEAKITKMEGGVGTVCFATGMAAIAAVFLtLLRAGD 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 94 KVVAARDLYGGSFRWFNDKEKEGR--FFFEYTNTEDeMIAAITEDTDIVYIETPTNPLMIEFDIEKVAKIAHDKGAVVIV 171
Cdd:PRK05939 88 HLVSSQFLFGNTNSLFGTLRGLGVevTMVDATDVQN-VAAAIRPNTRMVFVETIANPGTQVADLAGIGALCRERGLLYVV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 172 DNTFYSPIYQTPITQGADIVVHSATKYLSGHNDVLAGVVVTSNQefYDKLYYN-----------------------LNTT 228
Cdd:PRK05939 167 DNTMTSPWLFRPKDVGASLVINSLSKYIAGHGNALGGAVTDTGL--FDWSAYPnifpayrkgdpqqwgltqirkkgLRDM 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 229 GPTLSPFDSYMLMRGLKTLKLRMEASTANAQEVVAFLEKSPAVKEVLYPG----------------KGGMISFKVANQDK 292
Cdd:PRK05939 245 GATLSSEAAHRIAIGAETLALRVDRSCSNALALAQFLEAHPKVARVYYPGlashpqharatelfrhYGGLLSFELADGID 324
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488979160 293 IPTIINSLKVFTFAESLGGVESLITyPTTQT-HADIPGDVRASYGLTDDLLRLSIGIEAAQDLIADLENALSL 364
Cdd:PRK05939 325 CFDFLNRLKLVIKATHLGDTRTLVI-PVAPTiYYEMGAERRASMGIADSLIRVSVGIEDEADLIADFEQALDA 396
|
|
| PRK07050 |
PRK07050 |
cystathionine beta-lyase; Provisional |
7-362 |
1.16e-48 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 180810 [Multi-domain] Cd Length: 394 Bit Score: 168.75 E-value: 1.16e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 7 LETILAHAGINSDEATGALASPIHFSTTYQHPE--------FGHSTGFDYTRTKNPTRATVEKTLAAIEKADYAIATSSG 78
Cdd:PRK07050 10 LQTRIVQPDDQIPPGFRSFVTPVARASTVVFPDlatmraldWRQDVQWRYGLHATPTSLALAQRLAEIEGGRHALLQPSG 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 79 MSAIVLA-FEIFPVGSKVVAARDLYG-------GSFRWFNdkeKEGRFFfeytnteDEMIAA-----ITEDTDIVYIETP 145
Cdd:PRK07050 90 LAAISLVyFGLVKAGDDVLIPDNAYGpnrdhgeWLARDFG---ITVRFY-------DPLIGAgiadlIQPNTRLIWLEAP 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 146 TNPLMIEFDIEKVAKIAHDKGAVVIVDNTFYSPIYQTPITQGADIVVHSATKYLSGHNDVLAGVVVTSNQEFYDKLYYNL 225
Cdd:PRK07050 160 GSVTMEVPDVPAITAAARARGVVTAIDNTYSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGATITADAELHAKLKLAR 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 226 NTTGPTLSPFDSYMLMRGLKTLKLRMEASTANAQEVVAFLEKSPAVKEVLYP----------------GKGGMISF---K 286
Cdd:PRK07050 240 MRLGIGVSADDCSLVLRGLPSLQVRLAAHDRSALEVAEWLKARPEIATVLHPalpdcpghafwmrdftGAGGLFSVvfdE 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488979160 287 VANQDKIPTIINSLKVFTFAESLGGVESL-ITYpttqthaDIPGDVRASYGLTDDLLRLSIGIEAAQDLIADLENAL 362
Cdd:PRK07050 320 RYSPAQVDAFVEALELFAIGWSWGGACSLaMPY-------DVASMRTAKWPHRGTLVRLYIGLEDEADLIADLEQAL 389
|
|
| cysta_beta_ly_B |
TIGR01324 |
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate ... |
9-362 |
4.76e-47 |
|
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 130391 [Multi-domain] Cd Length: 377 Bit Score: 163.89 E-value: 4.76e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 9 TILAHAGINSDEATGALASPIHFSTTYQHPEFGHSTGFD----YTRTKNPTRATVEKTLAAIEKADYAIATSSGMSAIVL 84
Cdd:TIGR01324 1 TRLIHSGRQPRFSQGSVNPPLQRASTVLFDSHAAQRRAKgeltYGRRGTLTHFALQDAMCELEGGAGCYLYPSGLAAVTN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 85 AFEIF-PVGSKVVAARDLYGGSFRWFNDKEKEGRFFFEYTNTE-DEMIAA-ITEDTDIVYIETPTNPLMIEFDIEKVAKI 161
Cdd:TIGR01324 81 SILAFvKAGDHVLMVDSAYEPTRYFCDIVLKRMGVDITYYDPLiGEDIATlIQPNTKVLFLEAPSSITFEIQDIPAIAKA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 162 AHDKGAVVIVDNTFYSPIYQTPITQGADIVVHSATKYLSGHNDVLAGVVVTsNQEFYDKLYYNLNTTGPTLSPFDSYMLM 241
Cdd:TIGR01324 161 ARNPGIVIMIDNTWAAGLLFKPLEHGVDISIQAGTKYLVGHSDIMIGTVVA-NARTWDQLREHSYLMGQMVDADDAYTTL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 242 RGLKTLKLRMEASTANAQEVVAFLEKSPAVKEVLYP----------------GKGGMISFKVA--NQDKIPTIINSLKVF 303
Cdd:TIGR01324 240 RGLRTLGVRLKQHQESSLAIAKWLSEQPEVARVLHPalpscpghefwkrdfsGSSGLFSFVLQrlTQKQVHAFLDHLQLF 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488979160 304 TFAESLGGVESLI--TYPTTQTHADIPGDvrasygLTDDLLRLSIGIEAAQDLIADLENAL 362
Cdd:TIGR01324 320 GLGYSWGGYESLAlcNQPELGHRPNIKRN------LEGPLIRVHIGLENVDDLKADLKAGF 374
|
|
| PRK05967 |
PRK05967 |
cystathionine beta-lyase; Provisional |
2-363 |
8.10e-47 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 235657 [Multi-domain] Cd Length: 395 Bit Score: 163.83 E-value: 8.10e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 2 TQEYQLETILAHAGINSDEATGALASPIHFSTTYQHPEF----GHSTGFDYTRTKNPTRATVEKTLAAIEKADYAIATSS 77
Cdd:PRK05967 8 TEKAGINTRLAHDGNDPGDYHGFVNPPVVHASTVLFPDAetmaTRGQKYTYGTRGTPTTDALCKAIDALEGSAGTILVPS 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 78 GMSAIVLAFEIF-PVGSKVVAARDLYGGSFRWFNDKEKEGRFFFEYTnteDEMIAA-----ITEDTDIVYIETPTNPLMI 151
Cdd:PRK05967 88 GLAAVTVPFLGFlSPGDHALIVDSVYYPTRHFCDTMLKRLGVEVEYY---DPEIGAgiaklMRPNTKVVHTEAPGSNTFE 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 152 EFDIEKVAKIAHDKGAVVIVDNTFYSPIYQTPITQGADIVVHSATKYLSGHNDVLAGvVVTSNQEFYDKLYYNLNTTGPT 231
Cdd:PRK05967 165 MQDIPAIAEAAHRHGAIVMMDNTWATPLYFRPLDFGVDISIHAATKYPSGHSDILLG-TVSANEKCWPQLLEAHGTLGLC 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 232 LSPFDSYMLMRGLKTLKLRMEASTANAQEVVAFLEKSPAVKEVLYP----------------GKGGMISFKVANQD---- 291
Cdd:PRK05967 244 AGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLEGRPDVARVLHPalpsfpgheiwkrdfsGASGIFSFVLAAGPekgk 323
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488979160 292 -KIPTIINSLKVFTFAESLGGVESLitypttQTHADIpGDVRASYGLTDD-LLRLSIGIEAAQDLIADLENALS 363
Cdd:PRK05967 324 aKAHAFLDALEIFGLGYSWGGYESL------ALHVKL-GDRTVAKAPYAGpVIRLQIGLEDVPDLKADLERGFA 390
|
|
| PLN02242 |
PLN02242 |
methionine gamma-lyase |
39-348 |
1.65e-44 |
|
methionine gamma-lyase
Pssm-ID: 215134 Cd Length: 418 Bit Score: 158.39 E-value: 1.65e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 39 EFGHSTGFD-YTRTKNPTRATVEKTLAAIEKADYAIATSSGMSAIVLAF-EIFPVGSKVVAARDLYGGSF----RWFNDK 112
Cdd:PLN02242 60 ELGPDRDFYiYSRHFNPTVLNLGRQMAALEGTEAAYCTASGMSAISSVLlQLCSSGGHVVASNTLYGGTHallaHFLPRK 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 113 EKEGRFFFEYTNTEDEMIAAITEDTDIVYIETPTNPLMIEFDIEKVAKIAHDKGAVVIVDNTFySPIYQTPITQGADIVV 192
Cdd:PLN02242 140 CNITTTFVDITDLEAVKKAVVPGKTKVLYFESISNPTLTVADIPELARIAHEKGVTVVVDNTF-APMVLSPARLGADVVV 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 193 HSATKYLSGHNDVLAGVV------VTSNQEFYDKlyyNLNTTGPTLSPFDSYMLMRGLKTLKLRMEASTANAQEVVAFLE 266
Cdd:PLN02242 219 HSISKFISGGADIIAGAVcgpaelVNSMMDLHHG---ALMLLGPTMNPKVAFELSERLPHLSLRMKEHCRRAMEYAKRMK 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 267 KSPAvkEVLYPG-------------------KGGMISFKVANQDKIPTIINSLKVFT----FAESLGGVESLITYPTTQT 323
Cdd:PLN02242 296 ELGL--KVIYPGledhpqhallksmankgygFGGLLCLDMDTEERANRLMRYLQNSTqfgfMAVSLGYYETLMSCSGSST 373
|
330 340
....*....|....*....|....*
gi 488979160 324 HADIPGDVRASYGLTDDLLRLSIGI 348
Cdd:PLN02242 374 SSELDPEEKAAAGISPGLVRMSVGY 398
|
|
| PRK06702 |
PRK06702 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
28-362 |
2.75e-43 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 102505 [Multi-domain] Cd Length: 432 Bit Score: 155.21 E-value: 2.75e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 28 PIHFSTTYQHPEFG--------HSTGFDYTRTKNPTRATVEKTLAAIEKADYAIATSSGMSAIVLA-FEIFPVGSKVVAA 98
Cdd:PRK06702 27 PLYQSTTYKYDTSDdlaalfnlEAEGYIYTRIGNPTLAAFEQKLAELEGGVGAVATASGQAAIMLAvLNICSSGDHLLCS 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 99 RDLYGGSFRWFNDKEKE---GRFFFEYTNTEDEMIAAITEDTDIVYIETPTNPLMIEFDIEKVAKIAHDKGAVVIVDNTF 175
Cdd:PRK06702 107 STVYGGTFNLFGVSLRKlgiDVTFFNPNLTADEIVALANDKTKLVYAESLGNPAMNVLNFKEFSDAAKELEVPFIVDNTL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 176 YSPIYQTPITQGADIVVHSATKYLSGHNDVLAGVVVTSN-------------------------QEFYDKLYYN------ 224
Cdd:PRK06702 187 ATPYLCQAFEHGANIIVHSTTKYIDGHASSLGGIVIDGGnfdwtngkypelvepdpsyhgvsyvQNFGAAAYIVkarvql 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 225 LNTTGPTLSPFDSYMLMRGLKTLKLRMEASTANAQEVVAFLEKSPAVKEVLYPGKGGMISFKVANQ-------------- 290
Cdd:PRK06702 267 LRDYGNCMSPFNAYISNIGLETLHLRMERHSENALAVAKWLADHERIEWVNYPGLDSNENYSLAQKylkkgasgvltfgi 346
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488979160 291 ----DKIPTIINSLKVFTFAESLGGVESLITYPTTQTHADIPGDVRASYGLTDDLLRLSIGIEAAQDLIADLENAL 362
Cdd:PRK06702 347 kgglEAAKEFIANVKLATLVTHVADARTCVIHPASTTHRQLSAEDQRLAGVTSDLIRLSVGIEDVSDIIADLEAAL 422
|
|
| PRK09028 |
PRK09028 |
cystathionine beta-lyase; Provisional |
127-363 |
1.43e-38 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181615 [Multi-domain] Cd Length: 394 Bit Score: 141.79 E-value: 1.43e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 127 DEMIAA-----ITEDTDIVYIETPTNPLMIEFDIEKVAKIAHDKGAVVIVDNTFYSPIYQTPITQGADIVVHSATKYLSG 201
Cdd:PRK09028 132 DPMIGEgirelIRPNTKVLFLESPGSITMEVQDVPTLSRIAHEHDIVVMLDNTWASPINSRPFEMGVDISIQAATKYIVG 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 202 HNDVLAGvVVTSNQEFYDKLYYNLNTTGPTLSPFDSYMLMRGLKTLKLRMEASTANAQEVVAFLEKSPAVKEVLYP---- 277
Cdd:PRK09028 212 HSDVMLG-TATANEKHWDQLREHSYLMGQCTSPDDVYLAMRGLRTLGVRLAQHEKNALKVANWLATRPEVDHVRHPafet 290
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 278 ------------GKGGMISF--KVANQDKIPTIINSLKVFTFAESLGGVESLITYPT------TQTHADIPGdvrasygl 337
Cdd:PRK09028 291 cpgheffkrdfsGSNGLFSFvlKQGDPKAVTALVEGMQHFKMGFSWGGFESLILGVFginklrTATNWDFSK-------- 362
|
250 260
....*....|....*....|....*.
gi 488979160 338 tdDLLRLSIGIEAAQDLIADLENALS 363
Cdd:PRK09028 363 --PLIRLHIGLEDVDDLIADLEAGFE 386
|
|
| PRK08114 |
PRK08114 |
cystathionine beta-lyase; Provisional |
127-359 |
3.50e-31 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181231 [Multi-domain] Cd Length: 395 Bit Score: 121.73 E-value: 3.50e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 127 DEMIAA-----ITEDTDIVYIETPTNPLMIEFDIEKVAKIAHDKG--AVVIVDNTFYSPIYQTPITQGADIVVHSATKYL 199
Cdd:PRK08114 133 DPLIGAdiaklIQPNTKVVFLESPGSITMEVHDVPAIVAAVRSVNpdAVIMIDNTWAAGVLFKALDFGIDISIQAGTKYL 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 200 SGHNDVLAGVVVtSNQEFYDKLYYNLNTTGPTLSPFDSYMLMRGLKTLKLRMEASTANAQEVVAFLEKSPAVKEVLYP-- 277
Cdd:PRK08114 213 VGHSDAMIGTAV-ANARCWEQLRENSYLMGQMVDADTAYMTSRGLRTLGVRLRQHEESSLKVAEWLAEHPEVARVNHPal 291
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 278 --------------GKGGMISF---KVANQDKIPTIINSLKVFTFAESLGGVESLITYPTTQTHADI-PGDVRasyGLTD 339
Cdd:PRK08114 292 pgckghefwkrdftGSSGLFSFvlkKKLTDEQLANYLDNFSLFSMAYSWGGFESLILANQPEEIAAIrPAGEV---DFTG 368
|
250 260
....*....|....*....|
gi 488979160 340 DLLRLSIGIEAAQDLIADLE 359
Cdd:PRK08114 369 TLIRLHIGLEDVDDLIADLA 388
|
|
| AAT_like |
cd00609 |
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
68-282 |
8.84e-09 |
|
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.
Pssm-ID: 99734 [Multi-domain] Cd Length: 350 Bit Score: 56.20 E-value: 8.84e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 68 KADYAIATSSGMSAIVLAFEIF-PVGSKVVAAR---DLYGGSFRWFNDK------EKEGRFFfeytNTEDEMIAAITEDT 137
Cdd:cd00609 58 PPEEIVVTNGAQEALSLLLRALlNPGDEVLVPDptyPGYEAAARLAGAEvvpvplDEEGGFL----LDLELLEAAKTPKT 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 138 DIVYIETPTNP---LMIEFDIEKVAKIAHDKGAVVIVDNTFYSPIYQ---TPITQGAD-----IVVHSATKYLSghndvL 206
Cdd:cd00609 134 KLLYLNNPNNPtgaVLSEEELEELAELAKKHGILIISDEAYAELVYDgepPPALALLDayervIVLRSFSKTFG-----L 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 207 A----GVVVTSNQEFYDKLYYNLNTTGPTLSPFDSYMLMRGLKT----LKLRMEASTANAQEVVAFLEKSPavKEVLYPG 278
Cdd:cd00609 209 PglriGYLIAPPEELLERLKKLLPYTTSGPSTLSQAAAAAALDDgeehLEELRERYRRRRDALLEALKELG--PLVVVKP 286
|
....
gi 488979160 279 KGGM 282
Cdd:cd00609 287 SGGF 290
|
|
| PRK00451 |
PRK00451 |
aminomethyl-transferring glycine dehydrogenase subunit GcvPA; |
127-192 |
1.19e-06 |
|
aminomethyl-transferring glycine dehydrogenase subunit GcvPA;
Pssm-ID: 234769 [Multi-domain] Cd Length: 447 Bit Score: 50.14 E-value: 1.19e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 127 DEMIAAITEDTDIVYIETPTNPLMIEfDIEKVAKIAHDKGAVVIVdntFYSPI----YQTPITQGADIVV 192
Cdd:PRK00451 195 EALEAAVDDDTAAVVVQYPNFFGVIE-DLEEIAEIAHAGGALFIV---GVDPVslglLKPPGEYGADIVV 260
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
60-201 |
5.99e-06 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 45.84 E-value: 5.99e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 60 EKTLAAI--EKADYAIATSSGMSAIVLAFE---------IFPV---GSKVVAARDLYGGSFRWFNDKEKEgrfffEYTNT 125
Cdd:cd01494 6 EEKLARLlqPGNDKAVFVPSGTGANEAALLallgpgdevIVDAnghGSRYWVAAELAGAKPVPVPVDDAG-----YGGLD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 126 EDEMI-AAITEDTDIVYIETPTNPLMIEFDIEKVAKIAHDKGAVVIVDNT---FYSPIYQTPI-TQGADIVVHSATKYLS 200
Cdd:cd01494 81 VAILEeLKAKPNVALIVITPNTTSGGVLVPLKEIRKIAKEYGILLLVDAAsagGASPAPGVLIpEGGADVVTFSLHKNLG 160
|
.
gi 488979160 201 G 201
Cdd:cd01494 161 G 161
|
|
| Aminotran_5 |
pfam00266 |
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes ... |
125-172 |
2.68e-05 |
|
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.
Pssm-ID: 425567 [Multi-domain] Cd Length: 368 Bit Score: 45.70 E-value: 2.68e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 488979160 125 TEDEMIAAITEDTDIVYIETPTNPLMIEFDIEKVAKIAHDKGAVVIVD 172
Cdd:pfam00266 128 DLDELEKLITPKTKLVAITHVSNVTGTIQPVPEIGKLAHQYGALVLVD 175
|
|
| GcvP1 |
COG0403 |
Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport ... |
127-192 |
2.34e-04 |
|
Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain is part of the Pathway/BioSystem: Glycine cleavage
Pssm-ID: 440172 [Multi-domain] Cd Length: 442 Bit Score: 42.71 E-value: 2.34e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488979160 127 DEMIAAITEDTDIVYIETPtNPL-MIEfDIEKVAKIAHDKGAVVIV--DntfysPI----YQTPITQGADIVV 192
Cdd:COG0403 196 EALKALLDDDVAGVLVQYP-NFFgVIE-DLRAIAEAAHAAGALVIVaaD-----PLslglLKPPGELGADIVV 261
|
|
| SelA |
pfam03841 |
L-seryl-tRNA selenium transferase; |
57-224 |
6.90e-04 |
|
L-seryl-tRNA selenium transferase;
Pssm-ID: 309101 Cd Length: 367 Bit Score: 41.17 E-value: 6.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 57 ATVEKTLAAIEKADYAIATSSGMSAIVLAFEIFPVGSKVVAAR-DLY--GGSFRWFNDKEKEGRFFFEYTNTEDEMI--- 130
Cdd:pfam03841 50 AHIEELLCELTGAEDALVVNNNAAAVLLVLNTLAAGKEVIISRgELVeiGGSFRIPDVMKQAGVKLVEVGTTNRTHLkdy 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 131 -AAITEDTDIVYIETPTNPLMIEF----DIEKVAKIAHDKGAVVIVD---------NTF---YSPIYQTPITQGADIVVH 193
Cdd:pfam03841 130 eQAINENTALLMKVHTSNYRIQGFtkevELAELVELGHEKGLPVYEDlgsgslvdlSQYglpKEPTVQELIAQGVDLVSF 209
|
170 180 190
....*....|....*....|....*....|.
gi 488979160 194 SATKYLSGhndVLAGVVVtSNQEFYDKLYYN 224
Cdd:pfam03841 210 SGDKLLGG---PQAGIIV-GKKELIERIKKN 236
|
|
| Aminotran_1_2 |
pfam00155 |
Aminotransferase class I and II; |
67-172 |
2.25e-03 |
|
Aminotransferase class I and II;
Pssm-ID: 395103 [Multi-domain] Cd Length: 351 Bit Score: 39.60 E-value: 2.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979160 67 EKADYAIATSSGMSAIVLAFE--IFPVGSKVV-----------AARdLYGGSFRWFNDKEKEGrfffeYTNTEDEMIAAI 133
Cdd:pfam00155 60 LDREAAVVFGSGAGANIEALIflLANPGDAILvpaptyasyirIAR-LAGGEVVRYPLYDSND-----FHLDFDALEAAL 133
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 488979160 134 TEDTDIVYIETPTNPLMIEF---DIEKVAKIAHDKGAVVIVD 172
Cdd:pfam00155 134 KEKPKVVLHTSPHNPTGTVAtleELEKLLDLAKEHNILLLVD 175
|
|
| PRK06225 |
PRK06225 |
pyridoxal phosphate-dependent aminotransferase; |
120-175 |
6.49e-03 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 235749 [Multi-domain] Cd Length: 380 Bit Score: 38.20 E-value: 6.49e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 488979160 120 FEYTNTEDEMIAAITEDTDIVYIETPTNPL---MIEFDIEKVAKIAHDKGAVVIVDNTF 175
Cdd:PRK06225 141 CNYKLTPELVKENMDENTRLIYLIDPLNPLgssYTEEEIKEFAEIARDNDAFLLHDCTY 199
|
|
| |
