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Conserved domains on  [gi|488472574|ref|WP_002516244|]
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MULTISPECIES: polyphosphate--glucose phosphotransferase [Cutibacterium]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ASKHA_NBD_ROK_PPGK cd24058
nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK ...
 93-335 2.88e-119

nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK (EC 2.7.1.63/EC 2.7.1.2), also called poly(P)/ATP-glucomannokinase (GMK), poly(P) glucokinase, ATP-dependent glucokinase, or polyphosphate--glucose phosphotransferase, catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. Polyphosphate, rather than ATP, seems to be the major phosphate donor for the enzyme in Mycobacterium tuberculosis. GTP, UTP and CTP can replace ATP as phosphoryl donor. PPGK belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this family lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


:

Pssm-ID: 466908 [Multi-domain]  Cd Length: 239  Bit Score: 344.55  E-value: 2.88e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574  93 VLGIDVGGSGIKGAPVDLEVGDFAEPRLRIPTPEKSSPENIVTVLREIVDNFAPtigDGPVGISFPAPARHGVIPFIANL 172
Cdd:cd24058    1 ILGIDIGGSGIKGAIVDTDTGELLSERIRIPTPQPATPEAVADVVAELVAHFPW---FGPVGVGFPGVVRRGVVRTAANL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 173 DQGWAGLHAEKYISDALGRPVTVLNDADAAGVGEVHYGAARGVPGVVVLTTLGTGIGSAVINNGILLPNTELGHLEIDGH 252
Cdd:cd24058   78 DKSWIGFDAAKLLSKRLGRPVRVLNDADAAGLAEMKGGAGKGEKGVVLVLTLGTGIGSALFVDGHLVPNTELGHLEIRGK 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 253 DAEKRAASSVKDRKHMSYKDWAtKRLQRYYEVVEMLFSPDLFVVGGGISKDHKKFFKYLKLETPMVPAQLLNRAGIIGAA 332
Cdd:cd24058  158 DAEERASLGVRAREDLGWKRWA-KRVNKYLQYLERLFNPDLFIIGGGNSKKADKFLPLLDVKTPVVPAVLRNDAGIVGAA 236


                 ...
gi 488472574 333 WQA 335
Cdd:cd24058  237 LLA 239
YdbT super family cl28701
Uncharacterized membrane protein YdbT, contains bPH2 (bacterial pleckstrin homology) domain ...
 2-58 1.20e-11

Uncharacterized membrane protein YdbT, contains bPH2 (bacterial pleckstrin homology) domain [Function unknown];


The actual alignment was detected with superfamily member COG3428:

Pssm-ID: 442654 [Multi-domain]  Cd Length: 410  Bit Score: 65.50  E-value: 1.20e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 488472574   2 FTWTVSVVPHARSQSVRLSQGPIQRKLGLADIDVHTSSGPVTVSCPHLDAMDAQVFA 58
Cdd:COG3428  347 LTRRTVVVPRDRIQSVRLSQSPFQRRLGLATVRVDTAAGPGSYTVPDLDAEDARALA 403
 
Name Accession Description Interval E-value
ASKHA_NBD_ROK_PPGK cd24058
nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK ...
 93-335 2.88e-119

nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK (EC 2.7.1.63/EC 2.7.1.2), also called poly(P)/ATP-glucomannokinase (GMK), poly(P) glucokinase, ATP-dependent glucokinase, or polyphosphate--glucose phosphotransferase, catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. Polyphosphate, rather than ATP, seems to be the major phosphate donor for the enzyme in Mycobacterium tuberculosis. GTP, UTP and CTP can replace ATP as phosphoryl donor. PPGK belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this family lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466908 [Multi-domain]  Cd Length: 239  Bit Score: 344.55  E-value: 2.88e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574  93 VLGIDVGGSGIKGAPVDLEVGDFAEPRLRIPTPEKSSPENIVTVLREIVDNFAPtigDGPVGISFPAPARHGVIPFIANL 172
Cdd:cd24058    1 ILGIDIGGSGIKGAIVDTDTGELLSERIRIPTPQPATPEAVADVVAELVAHFPW---FGPVGVGFPGVVRRGVVRTAANL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 173 DQGWAGLHAEKYISDALGRPVTVLNDADAAGVGEVHYGAARGVPGVVVLTTLGTGIGSAVINNGILLPNTELGHLEIDGH 252
Cdd:cd24058   78 DKSWIGFDAAKLLSKRLGRPVRVLNDADAAGLAEMKGGAGKGEKGVVLVLTLGTGIGSALFVDGHLVPNTELGHLEIRGK 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 253 DAEKRAASSVKDRKHMSYKDWAtKRLQRYYEVVEMLFSPDLFVVGGGISKDHKKFFKYLKLETPMVPAQLLNRAGIIGAA 332
Cdd:cd24058  158 DAEERASLGVRAREDLGWKRWA-KRVNKYLQYLERLFNPDLFIIGGGNSKKADKFLPLLDVKTPVVPAVLRNDAGIVGAA 236


                 ...
gi 488472574 333 WQA 335
Cdd:cd24058  237 LLA 239
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 90-335 1.29e-41

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 147.74  E-value: 1.29e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574  90 MNKVLGIDVGGSGIKGAPVDLEvGDFAEpRLRIPTPEKSSPENIVTVLREIVDNFAPTIGDGP-----VGISFPAP--AR 162
Cdd:COG1940    4 AGYVIGIDIGGTKIKAALVDLD-GEVLA-RERIPTPAGAGPEAVLEAIAELIEELLAEAGISRgrilgIGIGVPGPvdPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 163 HGVIPFIANLDqGWAGLHAEKYISDALGRPVTVLNDADAAGVGEVHYGAARGVPGVVVLtTLGTGIGSAVINNGILLPNT 242
Cdd:COG1940   82 TGVVLNAPNLP-GWRGVPLAELLEERLGLPVFVENDANAAALAEAWFGAGRGADNVVYL-TLGTGIGGGIVINGKLLRGA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 243 -----ELGHLEIDGHDAE------------------KRAASSVKDRKHMSYKD----------WATKRLQRYYEV----- 284
Cdd:COG1940  160 ngnagEIGHMPVDPDGPLcgcgnrgcletyasgpalLRRARELGGAEKLTAEElfaaaragdpLALEVLDEAARYlgigl 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488472574 285 --VEMLFSPDLFVVGGGISKDHKKFFKYLK------------LETPMVPAQLLNRAGIIGAAWQA 335
Cdd:COG1940  240 anLINLLDPEVIVLGGGVSAAGDLLLEPIRealakyalpparEDPRIVPASLGDDAGLLGAAALA 304
ROK pfam00480
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ...
 94-336 1.31e-24

ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.


Pssm-ID: 395384 [Multi-domain]  Cd Length: 292  Bit Score: 101.65  E-value: 1.31e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574   94 LGIDVGGSGIKGAPVDLEvGDFAEpRLRIPTPEKSSPENIVTVLREIVDnFAPTIGDGP--VGISFPAPAR--HGVIPFI 169
Cdd:pfam00480   1 IGIDIGGTKIAAALFDEE-GEILA-RERVPTPTTTTEETLVDAIAFFVD-SAQRKFGELiaVGIGSPGLISpkYGYITNT 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574  170 ANLdqGWAGLHAEKYISDALGRPVTVLNDADAAGVGEVHYGAARGVPGVVVLtTLGTGIGSAVINNGILL-----PNTEL 244
Cdd:pfam00480  78 PNI--GWDNFDLVEKLEERFNVPVFFENDANAAALAEAVFGASKDVQNVIYV-TVGTGVGGGVISNGKLFtgrngVAGEI 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574  245 GHLEIDGHDA-------------------EKRAASSVKDrkhMSYKD----------WATKRLQRYYE-------VVEML 288
Cdd:pfam00480 155 GHIQLDPNGPkcgcgnhgcletiasgralEKRYQQKGED---LEGKDiivlaeqgdeVAEEAVERLARylakaiaNLINL 231

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574  289 FSPDLFVVGGGISKDH-------KKFFKYL--KLETP---MVPAQLLNRAGIIGAAWQAQ 336
Cdd:pfam00480 232 FDPQAIVLGGGVSNADglleairSLVKKYLngYLPVPpviIVAASLGDNAGALGAAALAK 291
YdbT COG3428
Uncharacterized membrane protein YdbT, contains bPH2 (bacterial pleckstrin homology) domain ...
 2-58 1.20e-11

Uncharacterized membrane protein YdbT, contains bPH2 (bacterial pleckstrin homology) domain [Function unknown];


Pssm-ID: 442654 [Multi-domain]  Cd Length: 410  Bit Score: 65.50  E-value: 1.20e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 488472574   2 FTWTVSVVPHARSQSVRLSQGPIQRKLGLADIDVHTSSGPVTVSCPHLDAMDAQVFA 58
Cdd:COG3428  347 LTRRTVVVPRDRIQSVRLSQSPFQRRLGLATVRVDTAAGPGSYTVPDLDAEDARALA 403
PRK09557 PRK09557
fructokinase; Reviewed
 94-333 1.50e-10

fructokinase; Reviewed


Pssm-ID: 236565 [Multi-domain]  Cd Length: 301  Bit Score: 61.58  E-value: 1.50e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574  94 LGIDVGGSGIkgapvdlEVGDFAEP-----RLRIPTPEKSSPENIVTVLrEIVDNFAPTIGD-GPVGISFPaparhGVI- 166
Cdd:PRK09557   3 IGIDLGGTKI-------EVIALDDAgeelfRKRLPTPRDDYQQTIEAIA-TLVDMAEQATGQrGTVGVGIP-----GSIs 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 167 PF---IANLDQGWAGLHA-EKYISDALGRPVTVLNDADAAGVGEVHYGAARGvPGVVVLTTLGTGIGSAV-IN------- 234
Cdd:PRK09557  70 PYtglVKNANSTWLNGQPlDKDLSARLNREVRLANDANCLAVSEAVDGAAAG-KQTVFAVIIGTGCGAGVaINgrvhigg 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 235 NGIllpNTELGHLEIDGHDAEKRAASS---------------------VKDRKHMSYK---------------DWATKRL 278
Cdd:PRK09557 149 NGI---AGEWGHNPLPWMDEDELRYRNevpcycgkqgcietfisgtgfATDYRRLSGKalkgseiirlveegdPVAELAF 225

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488472574 279 QRYYE--------VVEMLfSPDLFVVGGGIS----------KDHKKFFKYLKLETPMVPAQLLNRAGIIGAAW 333
Cdd:PRK09557 226 RRYEDrlakslahVINIL-DPDVIVLGGGMSnvdrlyptlpALLKQYVFGGECETPVRKALHGDSSGVRGAAW 297
bPH_2 pfam03703
Bacterial PH domain; Domain found in uncharacterized family of membrane proteins. 1-3 copies ...
 5-58 1.06e-07

Bacterial PH domain; Domain found in uncharacterized family of membrane proteins. 1-3 copies found in each protein, with each copy flanked by transmembrane helices. Members of this family have a PH domain like structure.


Pssm-ID: 427450 [Multi-domain]  Cd Length: 78  Bit Score: 48.75  E-value: 1.06e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 488472574    5 TVSVVPHARSQSVRLSQGPIQRKLGLADIDVHTSSGPvTVSCPHLDAMDAQVFA 58
Cdd:pfam03703  23 KRVDIPLERIQDVSLSQSPLQRRLGLGTIVIDTAGGS-GVRLPLRDVPDAEELR 75
 
Name Accession Description Interval E-value
ASKHA_NBD_ROK_PPGK cd24058
nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK ...
 93-335 2.88e-119

nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK (EC 2.7.1.63/EC 2.7.1.2), also called poly(P)/ATP-glucomannokinase (GMK), poly(P) glucokinase, ATP-dependent glucokinase, or polyphosphate--glucose phosphotransferase, catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. Polyphosphate, rather than ATP, seems to be the major phosphate donor for the enzyme in Mycobacterium tuberculosis. GTP, UTP and CTP can replace ATP as phosphoryl donor. PPGK belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this family lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466908 [Multi-domain]  Cd Length: 239  Bit Score: 344.55  E-value: 2.88e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574  93 VLGIDVGGSGIKGAPVDLEVGDFAEPRLRIPTPEKSSPENIVTVLREIVDNFAPtigDGPVGISFPAPARHGVIPFIANL 172
Cdd:cd24058    1 ILGIDIGGSGIKGAIVDTDTGELLSERIRIPTPQPATPEAVADVVAELVAHFPW---FGPVGVGFPGVVRRGVVRTAANL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 173 DQGWAGLHAEKYISDALGRPVTVLNDADAAGVGEVHYGAARGVPGVVVLTTLGTGIGSAVINNGILLPNTELGHLEIDGH 252
Cdd:cd24058   78 DKSWIGFDAAKLLSKRLGRPVRVLNDADAAGLAEMKGGAGKGEKGVVLVLTLGTGIGSALFVDGHLVPNTELGHLEIRGK 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 253 DAEKRAASSVKDRKHMSYKDWAtKRLQRYYEVVEMLFSPDLFVVGGGISKDHKKFFKYLKLETPMVPAQLLNRAGIIGAA 332
Cdd:cd24058  158 DAEERASLGVRAREDLGWKRWA-KRVNKYLQYLERLFNPDLFIIGGGNSKKADKFLPLLDVKTPVVPAVLRNDAGIVGAA 236


                 ...
gi 488472574 333 WQA 335
Cdd:cd24058  237 LLA 239
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 90-335 1.29e-41

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 147.74  E-value: 1.29e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574  90 MNKVLGIDVGGSGIKGAPVDLEvGDFAEpRLRIPTPEKSSPENIVTVLREIVDNFAPTIGDGP-----VGISFPAP--AR 162
Cdd:COG1940    4 AGYVIGIDIGGTKIKAALVDLD-GEVLA-RERIPTPAGAGPEAVLEAIAELIEELLAEAGISRgrilgIGIGVPGPvdPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 163 HGVIPFIANLDqGWAGLHAEKYISDALGRPVTVLNDADAAGVGEVHYGAARGVPGVVVLtTLGTGIGSAVINNGILLPNT 242
Cdd:COG1940   82 TGVVLNAPNLP-GWRGVPLAELLEERLGLPVFVENDANAAALAEAWFGAGRGADNVVYL-TLGTGIGGGIVINGKLLRGA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 243 -----ELGHLEIDGHDAE------------------KRAASSVKDRKHMSYKD----------WATKRLQRYYEV----- 284
Cdd:COG1940  160 ngnagEIGHMPVDPDGPLcgcgnrgcletyasgpalLRRARELGGAEKLTAEElfaaaragdpLALEVLDEAARYlgigl 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488472574 285 --VEMLFSPDLFVVGGGISKDHKKFFKYLK------------LETPMVPAQLLNRAGIIGAAWQA 335
Cdd:COG1940  240 anLINLLDPEVIVLGGGVSAAGDLLLEPIRealakyalpparEDPRIVPASLGDDAGLLGAAALA 304
ASKHA_ATPase_ROK cd23763
ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family ...
 94-332 1.52e-34

ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family corresponds to a group of proteins including sugar kinases, transcriptional repressors, and yet uncharacterized open reading frames. ROK family sugar kinases phosphorylate a range of structurally distinct hexoses including the key carbon source D-glucose, various glucose epimers, and several acetylated hexosamines. The sugar kinases include N-acetyl-D-glucosamine kinase (NAGK; EC 2.7.1.59), polyphosphate glucokinase (PPGK; EC 2.7.1.63/EC 2.7.1.2), glucokinase (GLK; EC 2.7.1.2), fructokinase (FRK; EC 2.7.1.4), hexokinase (HK; EC 2.7.1.1), D-allose kinase (AlsK; EC 2.7.1.55), bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE; EC 3.2.1.183/EC 2.7.1.60), N-acetylmannosamine kinase (NanK; EC 2.7.1.60), beta-glucoside kinase (BglK; EC 2.7.1.85), and N-acetylglucosamine kinase (EC 2.7.1.59). The family also contains the repressor proteins, such as N-acetylglucosamine repressor (NagC), xylose repressor (XylR), cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and protein Mlc. ROK kinases harbor a conserved N-terminal ATP binding motif of sequence DxGxT, while ROK repressors possess a N-terminal extension that contains a canonical helix-turn-helix DNA binding motif. The ROK family proteins belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466849 [Multi-domain]  Cd Length: 239  Bit Score: 126.81  E-value: 1.52e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574  94 LGIDVGGSGIKGAPVDLEVGDFAepRLRIPTPEKSSPENIVTVLREIVDNFAPTIGDGP----VGISFPAP--ARHGVIP 167
Cdd:cd23763    1 IGIDIGGTKIRAALVDLDGEILA--RERVPTPAEEGPEAVLDRIAELIEELLAEAGVRErilgIGIGVPGPvdPETGIVL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 168 FIANLDqGWAGLHAEKYISDALGRPVTVLNDADAAGVGEVHYGAARGVPGVVVLtTLGTGIGSAVINNGILL--PN---T 242
Cdd:cd23763   79 FAPNLP-WWKNVPLRELLEERLGLPVVVENDANAAALGEAWFGAGRGVRNFVYI-TLGTGIGGGIIIDGKLYrgANgaaG 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 243 ELGhleidghdaekraassvkdrkHMSYKDWATKRLQRYYEVVEMLFSPDLFVVGGGISKDHKKFFKYLKLE-------- 314
Cdd:cd23763  157 EIG---------------------HITVLEEAARYLGIGLANLINLLNPELIVLGGGVAEAGDLLLEPIREAvrrralpp 215

                        250       260
                 ....*....|....*....|..
gi 488472574 315 ----TPMVPAQLLNRAGIIGAA 332
Cdd:cd23763  216 lrrrVRIVPSELGDDAGLLGAA 237
ASKHA_NBD_ROK_FnNanK-like cd24068
nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and ...
 92-334 3.73e-31

nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and similar proteins; The family includes Fusobacterium nucleatum N-acetylmannosamine kinase (NanK; EC 2.7.1.60) and beta-glucoside kinase (BglK; EC 2.7.1.85) from Klebsiella pneumoniae and Listeria innocua. NanK catalyzes the second step of the sialic acid catabolic pathway, transferring a phosphate group from adenosine 5'-triphosphate to the C6 position of N-acetylmannosamine to generate N-acetylmannosamine 6-phosphate. Unlike other NanK enzymes and ROK family members, F. nucleatum NanK does not have a conserved zinc-binding site. BglK catalyzes the ATP-dependent phosphorylation of cellobiose to produce cellobiose-6'-P. It may have a dual role of kinase and transcriptional regulator of the cellobiose-PTS operon. The subfamily belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466918 [Multi-domain]  Cd Length: 294  Bit Score: 119.58  E-value: 3.73e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574  92 KVLGIDVGGSGIKGAPVDLEvGDFaEPRLRIPTPEKSSPENIVTVLREIVDNFaPTIGDgPVGISFPAP----ARHGVIP 167
Cdd:cd24068    1 KILGIDIGGTKIKYGLVDAD-GEI-LEKDSVPTPASKGGDAILERLLEIIAEL-KEKYD-IEGIGISSAgqvdPKTGEVI 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 168 FIANLDQGWAGLHAEKYISDALGRPVTVLNDADAAGVGEVHYGAARGVPGVVVLtTLGTGIGSAVINNGILLPNT----- 242
Cdd:cd24068   77 YATDNLPGWTGTNLKEELEERFGLPVAVENDVNCAALAEKWLGAAKGLDDFLCL-TLGTGIGGAIILDGRLYRGAngsag 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 243 ELGHLEIDGHDA----------EKRAASS--VKDRKHMSYKDWATKR--LQRYY-------EVVE--------------M 287
Cdd:cd24068  156 ELGHMVVDPGGRpcccggkgclEQYASGTalVRRVAEALGEPGIDGReiFDLADagdplakEVVEefaedlatglanlvH 235

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 488472574 288 LFSPDLFVVGGGIS--KDH----------KKFFKYLKLETPMVPAQLLNRAGIIGAAWQ 334
Cdd:cd24068  236 IFDPEVIVIGGGISaqGELfleelreelrKLLMPPLLDATKIEPAKLGNDAGLLGAAYL 294
ASKHA_NBD_ROK-like cd24152
nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This ...
 92-333 4.37e-28

nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This subfamily is composed of uncharacterized proteins belonging to the the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466988 [Multi-domain]  Cd Length: 286  Bit Score: 111.12  E-value: 4.37e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574  92 KVLGIDVGGSGIKGAPVDLEvGDFAEpRLRIPTPEKSSpENIVTVLREIVDNFAPTIgDGpVGISFPAP--------ARH 163
Cdd:cd24152    1 KYLVFDIGGTFIKYALVDEN-GNIIK-KGKIPTPKDSL-EEFLDYIKKIIKRYDEEI-DG-IAISAPGVidpetgiiYGG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 164 GVIPFIANLDqgWAGlhaekYISDALGRPVTVLNDADAAGVGEVHYGAARGVPGVVVLtTLGTGIGSAVINNGILL---P 240
Cdd:cd24152   76 GALPYLKGFN--LKE-----ELEERCNLPVSIENDAKCAALAELWLGSLKGIKNGAVI-VLGTGIGGAIIIDGKLYrgsH 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 241 NT--ELGHLEIDGHDAEKRAASS-------VKDRKHMSYKD---------WATKRLQRYYEVVE--------------ML 288
Cdd:cd24152  148 FFagEFSYLLTDDDDKDLLFFSGlasmfglVKRYNKAKGLEpldgeeifeKYAKGDEAAKKILDeyirnlakliyniqYI 227

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 488472574 289 FSPDLFVVGGGISKDH----------KKFFK---YLKLETPMVPAQLLNRAGIIGAAW 333
Cdd:cd24152  228 LDPEVIVIGGGISEQPlfiedlkkevNEILAnrpGSIPKPEIKACKFGNDANLLGALY 285
ROK pfam00480
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ...
 94-336 1.31e-24

ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.


Pssm-ID: 395384 [Multi-domain]  Cd Length: 292  Bit Score: 101.65  E-value: 1.31e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574   94 LGIDVGGSGIKGAPVDLEvGDFAEpRLRIPTPEKSSPENIVTVLREIVDnFAPTIGDGP--VGISFPAPAR--HGVIPFI 169
Cdd:pfam00480   1 IGIDIGGTKIAAALFDEE-GEILA-RERVPTPTTTTEETLVDAIAFFVD-SAQRKFGELiaVGIGSPGLISpkYGYITNT 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574  170 ANLdqGWAGLHAEKYISDALGRPVTVLNDADAAGVGEVHYGAARGVPGVVVLtTLGTGIGSAVINNGILL-----PNTEL 244
Cdd:pfam00480  78 PNI--GWDNFDLVEKLEERFNVPVFFENDANAAALAEAVFGASKDVQNVIYV-TVGTGVGGGVISNGKLFtgrngVAGEI 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574  245 GHLEIDGHDA-------------------EKRAASSVKDrkhMSYKD----------WATKRLQRYYE-------VVEML 288
Cdd:pfam00480 155 GHIQLDPNGPkcgcgnhgcletiasgralEKRYQQKGED---LEGKDiivlaeqgdeVAEEAVERLARylakaiaNLINL 231

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574  289 FSPDLFVVGGGISKDH-------KKFFKYL--KLETP---MVPAQLLNRAGIIGAAWQAQ 336
Cdd:pfam00480 232 FDPQAIVLGGGVSNADglleairSLVKKYLngYLPVPpviIVAASLGDNAGALGAAALAK 291
ASKHA_NBD_ROK_BsGLK-like cd24062
nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; ...
 92-333 9.86e-24

nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466912 [Multi-domain]  Cd Length: 311  Bit Score: 99.67  E-value: 9.86e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574  92 KVLGIDVGGSGIKGAPVDLEvGDFAEpRLRIPTPEKSSPENIVT--------VLREIVDNFAPTIGDGpVGISFPAPARH 163
Cdd:cd24062    1 WIVGIDVGGTTIKMAFLTQE-GEIVQ-KWEIPTNKLEGGENIITdiaesiqqLLEELGYSKEDLIGIG-VGVPGPVDVET 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 164 GVIPFIANLdqGWAGLHAEKYISDALGRPVTVLNDADAAGVGEVHYGAARGVPGVVVLtTLGTGIGSAVINNGILLPNT- 242
Cdd:cd24062   78 GTVEVAVNL--GWKNFPLKDKLEALTGIPVVIDNDANAAALGEMWKGAGQGAKDLVFI-TLGTGVGGGVIANGKIVHGAn 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 243 ----ELGHLEIDGHDAEK-------------RAASSVKDRKHMSYKDWATKRLQRYYE--------VVEM---------- 287
Cdd:cd24062  155 gaagEIGHITVNPEGGAPcncgktgcletvaSATGIVRIAREELEEGKGSSALRILALggeltakdVFEAakagdelala 234

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488472574 288 ------------------LFSPDLFVVGGGISK--DH-----KKFFKYLKL-----ETPMVPAQLLNRAGIIGAAW 333
Cdd:cd24062  235 vvdtvarylglalanlanTLNPEKIVIGGGVSAagEFllspvKEYFDRFTFprvrqDTEIVLATLGNDAGVIGAAW 310
ASKHA_NBD_ROK_TtHK-like cd24065
nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; ...
 92-332 5.73e-22

nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; HK (EC 2.7.1.1) possesses the ability to transfer an inorganic phosphate group from ATP to a substrate. It catalyzes the ATP-dependent phosphorylation of aldo- and keto-hexose sugars to the hexose-6-phosphate (H6P). Thermus thermophilus HK possesses significant enzymatic activity against glucose and mannose. However, it shows little catalytic capacity for galactose and fructose. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466915 [Multi-domain]  Cd Length: 289  Bit Score: 94.32  E-value: 5.73e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574  92 KVLGIDVGGSGIKGAPVDlevGDFAEPRLRIPTPEKSSpENIVTVLREIVDNFAPTIGD-GPVGISFPAP--ARHGVIPF 168
Cdd:cd24065    1 STIGLDLGGTKIAAGVVD---GGRILSRLVVPTPREGG-EAVLDALARAVEALQAEAPGvEAVGLGVPGPldFRRGRVRF 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 169 IANLdQGWAGLHAEKYISDALGRPVTVLNDADAAGVGEVHYGAARGVPGVVVLtTLGTGIGSAVINNGILLPNT-----E 243
Cdd:cd24065   77 APNI-PGLTDFPIRRGLAERLGLPVVLENDANAAALAEHHYGAARGTESSVYV-TISTGIGGGLVLGGRVLRGRhgqagE 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 244 LGHLEI--------DGHD----------AEKRAASSV----------------KDRKHMSYKDWATKRLQRYYEVVEMLF 289
Cdd:cd24065  155 IGHTTVlpggpmcgCGLVgclealasgrALARDASFAygrpmstaelfelaqqGEPKALRIVEQAAAHLGIGLANLQKAL 234

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 488472574 290 SPDLFVVGGGIS--------KDHKKFFKYLK--LETPMVPAQLLNRAGIIGAA 332
Cdd:cd24065  235 DPEVFVLGGGVAqvgdyyllPVQEAARRYTEgwHAPPLRLAHLGTDAGVIGAA 287
ASKHA_NBD_ROK_SgGLK-like cd24061
nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; ...
 94-335 1.80e-21

nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466911 [Multi-domain]  Cd Length: 306  Bit Score: 93.19  E-value: 1.80e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574  94 LGIDVGGSGIKGAPVDlEVGDFAEpRLRIPTPekSSPENIVTVLREIVDNFAPTIGDGPVGIS---FPAPARhGVIPFIA 170
Cdd:cd24061    2 IGVDIGGTKIAAGVVD-EEGEILA-TERVPTP--PTADGIVDAIVEAVEELREGHDVSAVGVAaagFVDADR-ATVLFAP 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 171 NLdqGWAGLHAEKYISDALGRPVTVLNDADAAGVGEVHYGAARGVPGVVVLtTLGTGIGSAVINNGILLPNT-----ELG 245
Cdd:cd24061   77 NI--AWRNEPLKDLLEARIGLPVVIENDANAAAWAEYRFGAGRGTDDMVMI-TVGTGLGGGIVIGGKLLRGAfgiagEFG 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 246 HLEI--DGH--------------------------------DAEKRAASSVKDR---KHMS-------------YKDWAT 275
Cdd:cd24061  154 HIRVvpDGLlcgcgsrgcweqyasgralvryakeaanatpeGAAVLLADGSVDGitgKHISeaaragdpvaldaLRELAR 233

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488472574 276 KrLQRYYEVVEMLFSPDLFVVGGGISKDHKKFFK--YLKLETPMV-----------PAQLLNRAGIIGAAWQA 335
Cdd:cd24061  234 W-LGAGLASLAALLDPELFVIGGGVSDAGDLLLDpiREAFERWLPgrgwrpiprlrTAQLGNDAGLIGAADLA 305
ASKHA_NBD_ROK_ApGLK-like cd24063
nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; ...
 93-332 1.96e-19

nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466913 [Multi-domain]  Cd Length: 308  Bit Score: 87.39  E-value: 1.96e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574  93 VLGIDVGGSGIKGAPVDLEVGDfaEPRLRIPTPEKSSPENIVTVLREIVDNFAPTIGDGPV---GISFPAP--ARHGVIP 167
Cdd:cd24063    2 YVAVDIGGTWIRAGLVDEDGRI--LLKIRQPTPKTGDPGTVSEQVLGLIETLLSKAGKDSIegiGVSSAGPldLRKGTIV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 168 FIANLDQGWAGLhaEKYISDALGRPVTVLNDADAAGVGEVHYGAARGVPGVVVLtTLGTGIGSAVINNGILLPN-----T 242
Cdd:cd24063   80 NSPNIKGKEIPL--VEPLKEEFNIPVALLNDAVAAALGEHLFGAGRGTSNLVYI-TISTGIGGGVIVDGRLLLGkngnaA 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 243 ELGHLEIDGHDAEK----------------------RAASSVKDRKHMSYKDWATKRL-------QRYY----------- 282
Cdd:cd24063  157 EVGHLVVDTESGLKcgcggyghweafasgrgiprfaREWAEGFSSRTSLKLRNPGGEGitakevfSAARkgdplalkiie 236

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 283 ---EVVEMLFS-------PDLFVVGGGISKDHKKFFKYLKLETP----------MVPAQLLNRAGIIGAA 332
Cdd:cd24063  237 klaRYNGRGIAnvinaydPELIVIGGSVFNNNKDILDPLIEYLEknpaiskgpeIVLSELGDDVGLIGAL 306
ASKHA_ATPase_ROK_BsXylR-like cd24076
ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This ...
 93-254 1.76e-17

ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Bacillus subtilis xylose repressor (BsXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. BsXylR acts as transcriptional repressor of xylose-utilizing enzymes.


Pssm-ID: 466926 [Multi-domain]  Cd Length: 303  Bit Score: 81.84  E-value: 1.76e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574  93 VLGIDVGGSGIKGAPVDLEvGDFAEpRLRIPTPEKSSPENIVTVLREIVDNFAPTIGDGP-----VGISFPAP--ARHGV 165
Cdd:cd24076    3 VIGVELGVDYITVVVTDLA-GEVLW-RREVPLPASDDPDEVLAQLAALIREALAAAPDSPlgilgIGVGVPGLvdSEDGV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 166 IPFIANLdqGWAGLHAEKYISDALGRPVTVLNDADAAGVGEVHYGAARGVPGVVVLtTLGTGIGSAVINNGILLPNT--- 242
Cdd:cd24076   81 VLLAPNL--GWRDVPLRDLLEEALGVPVFVDNEANAAALAEKRFGAGRGVSDLVYL-SAGVGIGAGIILDGELYRGAsgf 157

                        170
                 ....*....|....
gi 488472574 243 --ELGHLEIDGHDA 254
Cdd:cd24076  158 agEIGHMTVDPDGP 171
ASKHA_NBD_ROK_TM1224-like cd24059
nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and ...
 92-250 1.87e-16

nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to N-acetylglucosamine kinase (Tm1224; EC 2.7.1.59) from Thermotoga maritima, which belongs to kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Tm1224 lacks the cysteine-rich zinc-binding motif, which presents in other family members.


Pssm-ID: 466909 [Multi-domain]  Cd Length: 305  Bit Score: 78.78  E-value: 1.87e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574  92 KVLGIDVGGSGIKGAPVDLEvGDFAEpRLRIPTPEKSSPENIVTVLREIVDNFAPTIGDGP----VGISFPAP--ARHGV 165
Cdd:cd24059    2 YVIGVEIGRDLLSAVLCDLS-GNILA-REKYPLDEKENPEEVLEKLYELIDRLLEKENIKSkilgIGIGAPGPldVEKGI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 166 IPFIANLDqGWAGLHAEKYISDALGRPVTVLNDADAAGVGEVHYGAARGVPGVVVLtTLGTGIGSAVINNGILLPN---- 241
Cdd:cd24059   80 ILNPPNFP-GWENIPLVELLEEKFGIPVYLDNDANAAALAEKWYGKGKNYDNFIYI-LADEGIGAGIIINGKLYRGvdgy 157

                        170
                 ....*....|
gi 488472574 242 -TELGHLEID 250
Cdd:cd24059  158 aGEIGHTSID 167
ASKHA_NBD_ROK_TmGLK-like cd24064
nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; ...
 93-332 2.24e-16

nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466914 [Multi-domain]  Cd Length: 301  Bit Score: 78.69  E-value: 2.24e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574  93 VLGIDVGGSGIKGAPVDlEVGDFAEpRLRIPTPEKSSPENIVTVLREIVDNFAPTIGDGPVGISFPAPARH--GVIPFIA 170
Cdd:cd24064    1 VIGIDLGGTDTKIGIVD-ENGDILK-KKTIDTKVENGKEDVINRIAETVNELIEEMELLGIGIGSPGSIDRenGIVRFSP 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 171 NLdQGWAGLHAEKYISDALGRPVTVLNDADAAGVGEVHYGAARGVPGVVVLtTLGTGIGSAVINNGILLPN-----TELG 245
Cdd:cd24064   79 NF-PDWRNFPLVPLIEERTGIKVFLENDANAFALGEWWFGNAKGSNHIIGL-TLGTGVGSGVICHGQLLTGydgiaAELG 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 246 HLEIDGH------------------DAEKRAASSVKDRKHMSY----KDWATKRLQRYYE------------VVEML--- 288
Cdd:cd24064  157 HVIVEPNgpicgcgnrgcveafasaTAIIRYARESRKRYPDSLagesEKINAKHVFDAARkndplatmvfrrVVDALaia 236

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488472574 289 -------FSPDLFVVGGGISKDHKKFFKYLKLET------------PMVPAQLLNRAGIIGAA 332
Cdd:cd24064  237 iggfvhiFNPEIIIIGGGISRAGSFLLDPIREKTkkyvmlsfqdtySIELSNLVEDAGILGAA 299
ASKHA_NBD_ROK_EcFRK-like cd24066
nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; ...
 94-333 2.70e-16

nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; Escherichia coli FRK (EC 2.7.1.4), also called D-fructose kinase, manno(fructo)kinase, or MAK, catalyzes the phosphorylation of fructose to fructose-6-phosphate. It has also low level glucokinase activity in vitro. It is not able to phosphorylate D-ribose, D-mannitol, D-sorbitol, inositol, and L-threonine. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466916 [Multi-domain]  Cd Length: 294  Bit Score: 78.40  E-value: 2.70e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574  94 LGIDVGGSGIKGAPVDlevGDFAE-PRLRIPTPeKSSPENIVTVLREIVDNFAPTIG-DGPVGISFPAP--ARHGVI--- 166
Cdd:cd24066    2 IGIDLGGTKIEGIALD---RAGRElLRRRVPTP-RGDYEATLDAIADLVEEAEEELGaPATVGIGTPGSisPRTGLVkna 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 167 --------PFIANLDQgwaglhaekyisdALGRPVTVLNDADAAGVGEVHYGAARGVpGVVVLTTLGTGIGSAVINNGIL 238
Cdd:cd24066   78 nstwlngkPLKADLEA-------------RLGRPVRIENDANCFALSEATDGAGAGA-GVVFGVILGTGVGGGIVVNGRV 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 239 LPNT-----ELGHLEIDGHDA----------------------------------EKRAASSVKDRKHMSYKDwATKRLQ 279
Cdd:cd24066  144 LTGAngiagEWGHNPLPWPDEdelpgppcycgkrgcvetflsgpalerdyarltgKTLSAEEIVALARAGDAA-AVATLD 222

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488472574 280 RYYE--------VVEMLfSPDLFVVGGGISK-DH------KKFFKYL---KLETPMVPAQLLNRAGIIGAAW 333
Cdd:cd24066  223 RFLDrlgralanVINIL-DPDVIVLGGGLSNiDElytegpAALARYVfsdEVETPIVKNKHGDSSGVRGAAW 293
ASKHA_NBD_ROK_EcNanK-like cd24069
nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar ...
 94-333 1.32e-15

nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar proteins; N-acetylmannosamine kinase (NanK; EC 2.7.1.60), also called ManNAc kinase, or N-acetyl-D-mannosamine kinase, catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P. It has also low level glucokinase activity in vitro. This subfamily also contains Brucella melitensis bifunctional enzyme NanE/NanK (EC 5.1.3.9/EC 2.7.1.60), which also converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466919 [Multi-domain]  Cd Length: 283  Bit Score: 76.17  E-value: 1.32e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574  94 LGIDVGGSGIKGAPVDlevGDFAEPRLRIPTPEKSSPENIVTVLREIVdnfAPTIGD-GPVGISFPAPARHGVIPFI-AN 171
Cdd:cd24069    1 LAIDIGGTKIAAALIG---NGQIIDRRQIPTPRSGTPEALADALASLL---ADYQGQfDRVAVASTGIIRDGVLTALnPK 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 172 LDQGWAGLHAEKYISDALGRPVTVLNDADAAGVGEVHYGAARGVPGVVVLtTLGTGIGSAVINNGILL--PN---TELGH 246
Cdd:cd24069   75 NLGGLSGFPLADALQQLLGVPVVLLNDAQAAAWGEYQAGDGEGVGNLVFI-TVSTGVGGGLVLNGQLLtgPNglaGHIGH 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 247 LEIDGHDAE----KR-------------AASSVKDRKHMSYKD----------WATKRLQRYYEVVEMLFSP-------D 292
Cdd:cd24069  154 TLADPPGPVcgcgRRgcveaiasgtaiaAAASEILGEPVDAKDvferarsgdeEAARLIDRAARALADLIADlkatldlD 233

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 488472574 293 LFVVGGGISkDHKKFF----KYLKLE-----TPMVPAQLLNRAGIIGAAW 333
Cdd:cd24069  234 CVVIGGSVG-LAEGFLerveQYLADEpaifrVSLEPARLGQDAGLLGAAL 282
ASKHA_NBD_ROK_NAGK cd24057
nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; ...
 95-334 3.81e-15

nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; NAGK (EC 2.7.1.59), also called GlcNAc kinase, catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466907 [Multi-domain]  Cd Length: 298  Bit Score: 74.96  E-value: 3.81e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574  95 GIDVGGSGIKGAPVD--LEVGDFAeprlRIPTPeKSSPENIVTVLREIVDN-FAPTIGDGPVGISFP--APARHGVIpFI 169
Cdd:cd24057    4 GFDIGGTKIEFAVFDeaLQLVWTK----RVPTP-TDDYAAFLAAIAELVAEaDARFGVKGPVGIGIPgvIDPEDGTL-IT 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 170 ANLdQGWAGLHAEKYISDALGRPVTVLNDADAAGVGEVHYGAARGVPGVVVLtTLGTGIGSAVINNGILLPNT-----EL 244
Cdd:cd24057   78 ANI-PAAKGRPLRADLSARLGRPVRIDNDANCFALSEAWDGAGRGYPSVFGL-ILGTGVGGGLVVNGRLVGGRsgiagEW 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 245 GHLEIDGHDAEKRAASSVK----DRK-----------------HMS---------YKDW------ATKRLQRYYEVV-EM 287
Cdd:cd24057  156 GHGPLPADALLLGYDLPVLrcgcGQTgcletylsgrglerlyaHLYgeeldapeiIAAWaagdpqAVAHVDRWLDLLaGC 235

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488472574 288 L------FSPDLFVVGGGISKDH-------KKFFKYL--KLETP-MVPAQLLNRAGIIGAAWQ 334
Cdd:cd24057  236 LaniltaLDPDVVVLGGGLSNFPaliaelpAALPAHLlsGARTPrIVPARHGDAGGVRGAAFL 298
ASKHA_NBD_ROK_AlsK cd24070
nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1. ...
 91-332 3.03e-13

nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1.55), also called allokinase, catalyzes the phosphorylation of D-allose to D-allose 6-phosphate. It has also low level glucokinase activity in vitro. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466920 [Multi-domain]  Cd Length: 293  Bit Score: 69.50  E-value: 3.03e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574  91 NKVLGIDVGGSGIKGAPVD--LEVGDFAeprlRIPTPEKSSPENIVTVLREIVDNFAPTIGDGPVGISFPAPA-----RH 163
Cdd:cd24070    1 KYVLGIDIGGTNIRIGLVDedGKLLDFE----KVPSKDLLRAGDPVEVLADLIREYIEEAGLKPAAIVIGVPGtvdkdRR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 164 GVI--PFIANLDqgwaGLHAEKYISDALGRPVTVLNDADAAGVGEVHYGAARGvPGVVVLTTLGTGIGSAV-INNGILLP 240
Cdd:cd24070   77 TVIstPNIPGLD----GVNLADILENKLGIPVILERDVNLLLLYDMRAGNLDD-EGVVLGFYIGTGIGNAIlINGKPLRG 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 241 NT----ELGHLEIDGHD----------AEKRAA----------SSVKDRKHMSYKDWA-TKRLQRYYEVVEM-------L 288
Cdd:cd24070  152 KNgvagELGHIPVYGNGkpcgcgntgcLETYASgraleeiaeeHYPDTPILDIFVDHGdEPELDEFVEDLALaiateinI 231

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 488472574 289 FSPDLFVVGGGISkDHKKF-FKYLK------LETPmVPAQLLN--------RAGIIGAA 332
Cdd:cd24070  232 LDPDAVILGGGVI-DMKGFpRETLEeyirkhLRKP-YPADNLKiiyaelgpEAGVIGAA 288
YdbT COG3428
Uncharacterized membrane protein YdbT, contains bPH2 (bacterial pleckstrin homology) domain ...
 2-58 1.20e-11

Uncharacterized membrane protein YdbT, contains bPH2 (bacterial pleckstrin homology) domain [Function unknown];


Pssm-ID: 442654 [Multi-domain]  Cd Length: 410  Bit Score: 65.50  E-value: 1.20e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 488472574   2 FTWTVSVVPHARSQSVRLSQGPIQRKLGLADIDVHTSSGPVTVSCPHLDAMDAQVFA 58
Cdd:COG3428  347 LTRRTVVVPRDRIQSVRLSQSPFQRRLGLATVRVDTAAGPGSYTVPDLDAEDARALA 403
PRK09557 PRK09557
fructokinase; Reviewed
 94-333 1.50e-10

fructokinase; Reviewed


Pssm-ID: 236565 [Multi-domain]  Cd Length: 301  Bit Score: 61.58  E-value: 1.50e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574  94 LGIDVGGSGIkgapvdlEVGDFAEP-----RLRIPTPEKSSPENIVTVLrEIVDNFAPTIGD-GPVGISFPaparhGVI- 166
Cdd:PRK09557   3 IGIDLGGTKI-------EVIALDDAgeelfRKRLPTPRDDYQQTIEAIA-TLVDMAEQATGQrGTVGVGIP-----GSIs 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 167 PF---IANLDQGWAGLHA-EKYISDALGRPVTVLNDADAAGVGEVHYGAARGvPGVVVLTTLGTGIGSAV-IN------- 234
Cdd:PRK09557  70 PYtglVKNANSTWLNGQPlDKDLSARLNREVRLANDANCLAVSEAVDGAAAG-KQTVFAVIIGTGCGAGVaINgrvhigg 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 235 NGIllpNTELGHLEIDGHDAEKRAASS---------------------VKDRKHMSYK---------------DWATKRL 278
Cdd:PRK09557 149 NGI---AGEWGHNPLPWMDEDELRYRNevpcycgkqgcietfisgtgfATDYRRLSGKalkgseiirlveegdPVAELAF 225

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488472574 279 QRYYE--------VVEMLfSPDLFVVGGGIS----------KDHKKFFKYLKLETPMVPAQLLNRAGIIGAAW 333
Cdd:PRK09557 226 RRYEDrlakslahVINIL-DPDVIVLGGGMSnvdrlyptlpALLKQYVFGGECETPVRKALHGDSSGVRGAAW 297
ASKHA_NBD_ROK_GNE cd24060
nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase ...
 162-250 5.30e-10

nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) and similar proteins; GNE (EC 3.2.1.183/EC 2.7.1.60), also called UDP-GlcNAc-2-epimerase/ManAc kinase, is a bi-functional enzyme that plays a key role in sialic acid biosynthesis. It regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It plays an essential role in early development and required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. GNE is the only human protein that contains a kinase domain belonging to the ROK (repressor, ORF, kinase) family. Mutations of the GNE protein cause sialurea or autosomal recessive inclusion body myopathy/Nonaka myopathy.


Pssm-ID: 466910 [Multi-domain]  Cd Length: 305  Bit Score: 59.74  E-value: 5.30e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 162 RHGVIPFIANLDQGWAGLHAEKYISDALGRPVTVLNDADAAGVGEVHYGAARGVPGVVVLTTlGTGIGSAVINNGILLPN 241
Cdd:cd24060   74 REGIVLHSTKLIQEWSSVDLRTPISDALHLPVWVDNDGNCAALAERKFGHGKGVENFVTVIT-GTGIGGGIILNHELIHG 152

                         90
                 ....*....|....
gi 488472574 242 T-----ELGHLEID 250
Cdd:cd24060  153 SsfcaaELGHIVVS 166
ASKHA_ATPase_ROK_Lmo0178-like cd24071
ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily ...
 93-250 2.97e-09

ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Listeria monocytogenes Lmo0178 protein, which is a predicted transcription repressor belonging to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466921 [Multi-domain]  Cd Length: 312  Bit Score: 57.68  E-value: 2.97e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574  93 VLGIDVGGSGIKGAPVDLEvGDFAEpRLRIPTPEKSSPEN----IVTVLREIVDN---FAPTIGDGpVGISFPAPARHGV 165
Cdd:cd24071    3 IIGVKIEEGYLVLALTDLK-GKILE-KTRIPFDHETDPEKvielIAENIKKLIKNkhvEKKLLGIG-IAVSGLVDSKKGI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 166 IPFIANLdqGWAGLHAEKYISDALGRPVTVLNDADAAGVGEVHYGAARGVPGVVVLtTLGTGIGSAVINNGILLPNT--- 242
Cdd:cd24071   80 VIRSTIL--GWENVELKKILKEKFKIPVFIDNDVNSFALAELWKGKGKGYSNFICV-TVGAGIGSSLVIDGKLYTGNfgg 156

                        170
                 ....*....|
gi 488472574 243 --ELGHLEID 250
Cdd:cd24071  157 agEIGHMTIQ 166
PRK05082 PRK05082
N-acetylmannosamine kinase; Provisional
 92-252 1.20e-08

N-acetylmannosamine kinase; Provisional


Pssm-ID: 235338 [Multi-domain]  Cd Length: 291  Bit Score: 55.69  E-value: 1.20e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574  92 KVLGIDVGGSGIKGAPVDLEvGDFAEpRLRIPTPEKSSPENIVTVLREIVDNFAPTIGDgpVGISFPAPARHGVIPFI-- 169
Cdd:PRK05082   2 TTLAIDIGGTKIAAALVGED-GQIRQ-RRQIPTPASQTPEALRQALSALVSPLQAQADR--VAVASTGIINDGILTALnp 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 170 ANLDqGWAGLHAEKYISDALGRPVTVLNDADAAGVGEvhYGAARGVPGVVVLTTLGTGIGSAVINNGILL--PNTELGHL 247
Cdd:PRK05082  78 HNLG-GLLHFPLVQTLEQLTDLPTIALNDAQAAAWAE--YQALPDDIRNMVFITVSTGVGGGIVLNGKLLtgPGGLAGHI 154


                 ....*
gi 488472574 248 eidGH 252
Cdd:PRK05082 155 ---GH 156
YdbS COG3402
Uncharacterized membrane protein YdbS, contains bPH2 (bacterial pleckstrin homology) domain ...
 2-55 2.09e-08

Uncharacterized membrane protein YdbS, contains bPH2 (bacterial pleckstrin homology) domain [Function unknown];


Pssm-ID: 442629 [Multi-domain]  Cd Length: 143  Bit Score: 52.52  E-value: 2.09e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 488472574   2 FTWTVSVVPHARSQSVRLSQGPIQRKLGLADIDVHTSSGPVTVSCPHLDAMDAQ 55
Cdd:COG3402   80 LFRRRTVVPYGRIQHVDTEQGPLERLFGLATVTVTTAGSSGDVTIPGLPEEEAE 133
ASKHA_NBD_ROK_BsFRK-like cd24067
nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; ...
 93-332 3.60e-08

nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; Bacillus subtilis FRK (EC 2.7.1.4), also called glucomannan utilization protein E, catalyzes the phosphorylation of fructose to fructose-6-P. It seems to be involved in the degradation of glucomannan. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466917 [Multi-domain]  Cd Length: 285  Bit Score: 54.09  E-value: 3.60e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574  93 VLGIDVGGSGIKGApVDLEVGDFAEpRLRIPTpekSSPEnivTVLREIVDNFAPT--------IGD-GPVGISfPAPARH 163
Cdd:cd24067    1 FGGIEAGGTKFVCA-VGTGDGNIIE-RTEFPT---TTPE---ETLQAVIDFFREQeepidaigIASfGPIDLN-PTSPTY 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 164 GVI-----PfianldqGWAGLHAEKYISDALGRPVTVLNDADAAGVGEVHYGAARGVPGVVVLtTLGTGIG-SAVINN-- 235
Cdd:cd24067   72 GYItttpkP-------GWRNFDILGALKRAFPVPVGFDTDVNAAALAEYRWGAAKGLDSLAYI-TVGTGIGvGLVVNGkp 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 236 --GILLPntELGH-----LEIDG--------HDA--EKRAAS-SVKDRKHMSYKD-------WatkRLQRYY------EV 284
Cdd:cd24067  144 vhGLLHP--EMGHirvprHPDDDgfpgvcpfHGDclEGLASGpAIAARWGIPAEElpddhpaW---DLEAYYlaqacaNL 218

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488472574 285 VeMLFSPDLFVVGGGISKD-------HKKFFKYLK--LETP---------MVPAQLLNRAGIIGAA 332
Cdd:cd24067  219 T-LTLSPERIVLGGGVMQRpglfpriREKFRKLLNgyLEVPrllpdideyIVPPALGNDAGILGAL 283
bPH_2 pfam03703
Bacterial PH domain; Domain found in uncharacterized family of membrane proteins. 1-3 copies ...
 5-58 1.06e-07

Bacterial PH domain; Domain found in uncharacterized family of membrane proteins. 1-3 copies found in each protein, with each copy flanked by transmembrane helices. Members of this family have a PH domain like structure.


Pssm-ID: 427450 [Multi-domain]  Cd Length: 78  Bit Score: 48.75  E-value: 1.06e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 488472574    5 TVSVVPHARSQSVRLSQGPIQRKLGLADIDVHTSSGPvTVSCPHLDAMDAQVFA 58
Cdd:pfam03703  23 KRVDIPLERIQDVSLSQSPLQRRLGLGTIVIDTAGGS-GVRLPLRDVPDAEELR 75
ASKHA_ATPase_ROK_CYANR cd24073
ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; ...
 93-251 1.35e-07

ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; CYANR acts as transcriptional repressor of cyclobis-(1-6)-alpha-nigerosyl (CNN) degrading enzymes. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466923 [Multi-domain]  Cd Length: 304  Bit Score: 52.55  E-value: 1.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574  93 VLGIDVGGSGIKGAPVDLEVGDFAEPRLRIPTPeksSPENIVTVLREIVdnfAPTIGDGP--------VGISFPA--PAR 162
Cdd:cd24073    3 VVGVKLTEDRITAVLTDLRGNVLASHTLPLDSG---DPEAVAEAIAEAV---AELLAQAGlspdrllgIGVGLPGlvDAE 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 163 HGVIPFIANLdqGWAGLHAEKYISDALGRPVTVLNDADAAGVGEVHYGAARGVPGVVVLtTLGTGIGSAVINNGILLPNT 242
Cdd:cd24073   77 TGICRWSPLL--GWRDVPLAELLEERLGLPVYVENDVNALALAEHWFGAGRGLDNFAVV-TIGRGIGCGLVVDGRLYRGA 153

                        170
                 ....*....|....*.
gi 488472574 243 -----ELGH--LEIDG 251
Cdd:cd24073  154 hggagEIGHttVDPDG 169
PRK13310 PRK13310
N-acetyl-D-glucosamine kinase; Provisional
 95-326 1.13e-06

N-acetyl-D-glucosamine kinase; Provisional


Pssm-ID: 183967 [Multi-domain]  Cd Length: 303  Bit Score: 49.60  E-value: 1.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574  95 GIDVGGSGIkgapvdlEVGDFAEPR-----LRIPTPeKSSPENIVTVLREIVDNFAPTIG-DGPVGISFPA-PARHGVIP 167
Cdd:PRK13310   4 GFDIGGTKI-------ELGVFNEKLelqweERVPTP-RDSYDAFLDAVCELVAEADQRFGcKGSVGIGIPGmPETEDGTL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 168 FIANLDQGwAGLHAEKYISDALGRPVTVLNDADAAGVGEVHYGAARGVPGVVVLTtLGTGIGSAVINNGILLPNT----- 242
Cdd:PRK13310  76 YAANVPAA-SGKPLRADLSARLGRDVRLDNDANCFALSEAWDDEFTQYPLVMGLI-LGTGVGGGLVFNGKPISGRsyitg 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 243 ELGH-------LEIDGHDA-------EKRAA--SSVKDRK-HMSYKDW------ATKRLQRYYE-----------VVEML 288
Cdd:PRK13310 154 EFGHmrlpvdaLTLLGWDAplrrcgcGQKGCieNYLSGRGfEWLYQHYygeplqAPEIIALYYQgdeqavahverYLDLL 233

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 488472574 289 ----------FSPDLFVVGGGISKdhkkfFKYLKLETP-MVPAQLLNRA 326
Cdd:PRK13310 234 aiclgniltiVDPHLVVLGGGLSN-----FDAIYEQLPkRLPRHLLPVA 277
ASKHA_ATPase_ROK_YphH-like cd24072
ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily ...
 93-252 1.22e-06

ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Escherichia coli protein YphH that belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466922 [Multi-domain]  Cd Length: 308  Bit Score: 49.72  E-value: 1.22e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574  93 VLGIDVGGSGIKGAPVDL---EVGDFAEPRLRIPTPEKSSPENIVTVLREIVDNFAPTIGDGpVGISFPAPARHGVIPFI 169
Cdd:cd24072    3 VLGIVVSPNSLRAQVGNAcgeLLGEFEYRVITLETPEALIDEIIDCIDRLLKLWKDRVKGIA-LAIQGLVDSHKGVSLWS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 170 ANLDqgWAGLHAEKYISDALGRPVTVLNDADAAGVGEVHYGAARGVPGVVVLtTLGTGIGSA-VINNGILL----PNTEL 244
Cdd:cd24072   82 PGAP--WRNIEIKYLLEERYGIPVFVENDCNMLALAEKWQGELRQSRDFCVI-NLDYGIGSAiVIDNKLYIgassGSGEI 158

                        170
                 ....*....|
gi 488472574 245 GHL--EIDGH 252
Cdd:cd24072  159 GHTkvNPDGA 168
PRK13311 PRK13311
N-acetyl-D-glucosamine kinase; Provisional
 95-253 1.75e-06

N-acetyl-D-glucosamine kinase; Provisional


Pssm-ID: 106271 [Multi-domain]  Cd Length: 256  Bit Score: 48.87  E-value: 1.75e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574  95 GIDVGGSGIkgapvdlEVGDFAE--PRL---RIPTPEKSSPEnIVTVLREIVDNFAPTIG-DGPVGISFPA-PARHGVIP 167
Cdd:PRK13311   4 GFDMGGTKI-------ELGVFDEnlQRIwhkRVPTPREDYPQ-LLQILRDLTEEADTYCGvQGSVGIGIPGlPNADDGTV 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 168 FIANLDQGwAGLHAEKYISDALGRPVTVLNDADAAGVGEVHYGAARGVPGVVVLTtLGTGIGSAVINNGILLPNT----- 242
Cdd:PRK13311  76 FTANVPSA-MGQPLQADLSRLIQREVRIDNDANCFALSEAWDPEFRTYPTVLGLI-LGTGVGGGLIVNGSIVSGRnhitg 153

                        170
                 ....*....|...
gi 488472574 243 ELGH--LEIDGHD 253
Cdd:PRK13311 154 EFGHfrLPVDALD 166
BadF COG2971
BadF-type ATPase, related to human N-acetylglucosamine kinase [Carbohydrate transport and ...
 93-237 2.30e-04

BadF-type ATPase, related to human N-acetylglucosamine kinase [Carbohydrate transport and metabolism];


Pssm-ID: 442210 [Multi-domain]  Cd Length: 298  Bit Score: 42.56  E-value: 2.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574  93 VLGIDVGGSGIKGAPVDLE---VGDFAEPRLRIPTpekSSPENIVTVLREIVDNFAPTIGDgpvgisfPAPARHGVIpfi 169
Cdd:COG2971    3 ILGVDGGGTKTRAVLVDADgevLGRGRAGGANPQS---VGLEEALASLREALEEALAAAGD-------PADIEAVGF--- 69

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488472574 170 anldqGWAGLHAEKY---ISDAL-----GRPVTVLNDADAAgvgevHYGAARGVPGVVVLttLGTG-IGSAVINNGI 237
Cdd:COG2971   70 -----GLAGAGTPEDaeaLEAALrelfpFARVVVVNDALAA-----LAGALGGEDGIVVI--AGTGsIAAGRDGDGR 134
ASKHA_ATPase_ROK_Mlc cd24074
ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies ...
 184-252 2.68e-04

ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies protein, acts as a transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. It regulates the expression of malT. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466924 [Multi-domain]  Cd Length: 322  Bit Score: 42.30  E-value: 2.68e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488472574 184 YISDALGRPVTVLNDADAAGVGEVHYGAARGVPGVVVLTtLGTGIGSAVINNGILL-PNT----ELGHLEIDGH 252
Cdd:cd24074   97 ALEQHTGLPVYVQHDISAWTLAERFFGAAKGAKNIIQIV-IDDDIGAGVITDGQLLhAGSsrlgELGHTQIDPY 169
PRK09698 PRK09698
D-allose kinase; Provisional
 93-339 7.19e-04

D-allose kinase; Provisional


Pssm-ID: 182034 [Multi-domain]  Cd Length: 302  Bit Score: 41.12  E-value: 7.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574  93 VLGIDVGGSGIKGAPVDlEVGDFAEPRlRIPTPEKSSP---ENIVTVLREIVDNFAPTIGDgpVGISFPAPA---RHGVI 166
Cdd:PRK09698   6 VLGIDMGGTHIRFCLVD-AEGEILHCE-KKRTAEVIAPdlvSGLGEMIDEYLRRFNARCHG--IVMGFPALVskdRRTVI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 167 --PFIANLDQGWAGLhAEKyISDALGRPVTVLNDA------DAagvgeVHYgaaRGVPGVVVLTTLGTGIGSAVINNGIL 238
Cdd:PRK09698  82 stPNLPLTALDLYDL-ADK-LENTLNCPVFFSRDVnlqllwDV-----KEN---NLTQQLVLGAYLGTGMGFAVWMNGAP 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 239 LPNT-----ELGHL-------------------EIDGHDAEKRAASSVKDRK----------HMSYKDWaTKRLQRYYEV 284
Cdd:PRK09698 152 WTGAhgvagELGHIplgdmtqhcgcgnpgcletNCSGMALRRWYEQQPRDYPlsdlfvhagdHPFIQSL-LENLARAIAT 230

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488472574 285 VEMLFSPDLFVVGGGISkDHKKF---------FKYL-----KLETPMVPAQLLNRAGIIGAAWQAQWRL 339
Cdd:PRK09698 231 SINLFDPDAIILGGGVM-DMPAFpretliamiQKYLrkplpYEVVRFIYASSSDFNGAQGAAILAHQRF 298
ASKHA_ATPase_ROK_SaXylR-like cd24077
ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This ...
 93-238 7.73e-04

ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Staphylococcus aureus xylose repressor (SaXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. SaXylR acts as a transcriptional repressor of xylose-utilizing enzymes. It lacks the cysteine-rich zinc-binding motif, which presents in other family members.


Pssm-ID: 466927 [Multi-domain]  Cd Length: 295  Bit Score: 40.99  E-value: 7.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574  93 VLGIDVG-------GSGIKGAPVDLEvgdfaeprlRIPTPEKSsPENIVTVLREIVDNF---APTIGDGPVGISFpapAR 162
Cdd:cd24077    3 SIGIDLGynyislmLTYLDGEIISSK---------QIKLLDIS-FENILEILKSIIQELisqAPKTPYGLVGIGI---GI 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 163 HGV-----IPFIANLDqgWAGLHAEKYISDALGRPVTVLNDADAAGVGEvhYGAARGVPGVVVLTtLGTGIGSAVINNGI 237
Cdd:cd24077   70 HGIvdeneIIFTPYYD--LEDIDLKEKLEEKFNVPVYLENEANLSALAE--RTFSEDYDNLISIS-IHSGIGAGIIINNQ 144


                 .
gi 488472574 238 L 238
Cdd:cd24077  145 L 145
ASKHA_NBD_eukNAGK-like cd24007
nucleotide-binding domain (NBD) of the eukaryotic-type N-acetylglucosamine kinase (NAGK) ...
 93-227 9.11e-04

nucleotide-binding domain (NBD) of the eukaryotic-type N-acetylglucosamine kinase (NAGK) family; The eukaryotic-type NAGK-like family includes a group of proteins similar to eukaryotic N-acetyl-D-glucosamine kinases, such as Vibrio cholerae glucosamine kinase GspK, Sulfurisphaera tokodaii ATP-dependent hexokinase (StHK), Thermoplasma acidophilum 2-dehydro-3-deoxygluconokinase (KdgK) and Clostridium acetobutylicum N-acetylmuramic acid/N-acetylglucosamine kinase (MurK). NAGK (EC 2.7.1.59), also called GlcNAc kinase, converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. It is involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. NAGK also has ManNAc kinase activity. GspK (EC 2.7.1.8), also called GlcN kinase, acts as ATP-dependent kinase, which is specific for glucosamine. StHK is a novel hexokinase that can phosphorylate not only glucose but also GlcNAc, glucosamine, and mannose. KdgK (EC 2.7.1.45), also called 2-keto-3-deoxy-D-gluconate kinase, or KDG kinase, catalyzes the phosphorylation of 2-keto-3-deoxygluconate (KDG) to produce 2-keto-3-deoxy-6-phosphogluconate (KDPG). It is specific for KDG. MurK (EC 2.7.1.-/EC 2.7.1.59), also known MurNAc/GlcNAc kinase, or murein sugar kinase, catalyzes the ATP-dependent phosphorylation of both cell wall (peptidoglycan) amino sugars, N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), at the 6-hydroxyl group. The eukaryotic-type N-acetylglucosamine kinase (NAGK) family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466857 [Multi-domain]  Cd Length: 295  Bit Score: 40.75  E-value: 9.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574  93 VLGIDVGGSGIKGAPVDLEVGDFAEPRLRIPTPEKSSPENIVTVLREIVDnfaptigdgpvgisfPAPARHGVIPFIANL 172
Cdd:cd24007    1 VLGVDGGGTKTRAVLADEDGKILGRGKGGPSNPASVGIEEAKENLKEAVR---------------EALSQAGSLGEIDAI 65

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488472574 173 DQGWAGLHAEKY---ISDALGR-----PVTVLNDADAAgvgevHYGAARGVPGVVVLttLGTG 227
Cdd:cd24007   66 CLGLAGIDSEEDrerLRSALKElflsgRIIIVNDAEIA-----LAAALGGGPGIVVI--AGTG 121
ASKHA_NBD_FGGY_SHK cd07777
nucleotide-binding domain (NBD) of sedoheptulokinase (SHK) and similar proteins; SHK (EC 2.7.1. ...
 92-157 1.13e-03

nucleotide-binding domain (NBD) of sedoheptulokinase (SHK) and similar proteins; SHK (EC 2.7.1.14), also called heptulokinase, or carbohydrate kinase-like protein (CARKL), is encoded by the carbohydrate kinase-like (CARKL/SHPK) gene. It acts as a modulator of macrophage activation through control of glucose metabolism. SHK catalyzes the ATP-dependent phosphorylation of sedoheptulose to produce sedoheptulose 7-phosphate and ADP. The presence of Mg2+ or Mn2+ might be required for catalytic activity. Members of this subfamily belong to the FGGY family of carbohydrate kinases, the monomers of which contain two large domains, which are separated by a deep cleft that forms the active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain.


Pssm-ID: 466796 [Multi-domain]  Cd Length: 436  Bit Score: 40.67  E-value: 1.13e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488472574  92 KVLGIDVGGSGIKGAPVDLEVGDFAEpRLRIPTPEKS----------SPENIVTVLREIVDNFAPTIGDGPVGISF 157
Cdd:cd07777    1 NVLGIDIGTTSIKAALLDLESGRILE-SVSRPTPAPIssddpgrseqDPEKILEAVRNLIDELPREYLSDVTGIGI 75
ASKHA_NBD_GLK cd24008
nucleotide-binding domain (NBD) of glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7. ...
 93-255 5.55e-03

nucleotide-binding domain (NBD) of glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. Glucokinases are mainly found in invertebrates and microorganisms and highly specific for glucose. Glucokinases belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466858 [Multi-domain]  Cd Length: 313  Bit Score: 38.36  E-value: 5.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574  93 VLGIDVGGSGIKGAPVDLEVGDFAE-PRLRIPTPEKSSPENIVTVLREIVDNFAPTIgdgpVGISFPAPARHGVIPFiAN 171
Cdd:cd24008    1 ILVGDIGGTNARLALADAGDGSGDLlFVRKYPSADFASLEDALAAFLAELGAPRPKA----ACIAVAGPVDGGRVRL-TN 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 172 LDqgWAgLHAEKYISDALGRPVTVLNDADAAGVG----------EVHYGAARGVPGVVVLTTLGTGIGSAVINNG----- 236
Cdd:cd24008   76 LD--WS-IDAAELRKALGIGRVRLLNDFEAAAYGlpalgpedllVLYGGGGPLPGGPRAVLGPGTGLGVALLVPDgdggy 152

                        170
                 ....*....|....*....
gi 488472574 237 ILLPnTELGHLEIDGHDAE 255
Cdd:cd24008  153 VVLP-SEGGHADFAPVTEE 170
ASKHA_NBD_MurK-like cd24084
nucleotide-binding domain (NBD) of Clostridium acetobutylicum N-acetylmuramic acid ...
 93-292 7.62e-03

nucleotide-binding domain (NBD) of Clostridium acetobutylicum N-acetylmuramic acid/N-acetylglucosamine kinase (MurK) and similar proteins; The family includes a group of uncharacterized proteins similar to Clostridium acetobutylicum N-acetylmuramic acid/N-acetylglucosamine kinase (MurK; EC 2.7.1.-/EC 2.7.1.59), also known MurNAc/GlcNAc kinase, or murein sugar kinase. It catalyzes the ATP-dependent phosphorylation of both cell wall (peptidoglycan) amino sugars, N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), at the 6-hydroxyl group. Neither the non-N-acetylated forms of the cell wall sugars, i.e., glucosamine and/or muramic acid, nor epimeric hexoses or 1,6-anhydro-MurNAc are substrates for the enzyme. MurK may have a role in the rescue of the murein sugars GlcNAc and MurNAc released from muropeptides during cell wall turnover in C.acetobutylicum.


Pssm-ID: 466934 [Multi-domain]  Cd Length: 302  Bit Score: 37.72  E-value: 7.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574  93 VLGIDVGGSGIKGAPVDLEVGDFAEPRLRIPTPEKSSPENIVTVLREIVDNFAPTIGDGPVGISfpaparhGVIPFIANL 172
Cdd:cd24084    3 VIGIDGGGTKTHLKITDLNGNVVGEGFGGSSNLESNSLETVRENLKELFQDFYEQLGKSLKECG-------SICLGTAGA 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488472574 173 DQGWAGLHAEKYISDAL-GRPVTVLNDADAAgvgevHYGAARGVPGVVVLTtlGTG-IGSAVINNGILLPNTELGHLEID 250
Cdd:cd24084   76 SHQGAKETLKDILTELGpDAKIEVVNDAEIA-----LAAGLEGKPGIVLIS--GTGsICYGRNTDGETARAGGWGHLLGD 148

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 488472574 251 G----HDAEKRAASSVKDRKHMSYKDWATKRLQRYYevveMLFSPD 292
Cdd:cd24084  149 EgsgyWIAMQALGAVLQAFDGRGPKTILTELLLEEL----KLSSPR 190
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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