|
Name |
Accession |
Description |
Interval |
E-value |
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
203-589 |
1.80e-89 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 281.83 E-value: 1.80e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 203 ILKRMLKHPDENRSIIQQSSEWNELYETINLLSQQVSQTYKAYTSADEQFHELLDELMIGVFIIDTQGRLRLLNPKMQEM 282
Cdd:COG5002 2 LLLLLLLLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLAL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 283 LGLSAKNMQSNYLEVIQDADLIHLIHQVVAEKNSLHQEITVTQGPTPLRLDLSLRYLDDQSANDYQVLGIAYDLTRVRQL 362
Cdd:COG5002 82 ALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 363 EKMQKDFVSNVSHELKTPVTSLLGFTETLIDGAKEDPEVLNQFLHIMQKDAQRLQQLIQEILELSR-GSATIPYAEQEIT 441
Cdd:COG5002 162 EQMRREFVANVSHELRTPLTSIRGYLELLLDGAADDPEERREYLEIILEEAERLSRLVNDLLDLSRlESGELKLEKEPVD 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 442 LEKFITEILGSYQQQLAAKQLKTVVHGLPES-QFFTKYELFYPIVKNLIENAIQYSQENGQITISYAIENQQLRLSVQDT 520
Cdd:COG5002 242 LAELLEEVVEELRPLAEEKGIELELDLPEDPlLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDT 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488312470 521 GIGISQKDQERIFERFYRVDKARSRHSGGTGLGLAIVQNYTELLGGKIAIDSHLGLGTTFTITLPLTKK 589
Cdd:COG5002 322 GIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLARE 390
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
250-584 |
1.37e-80 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 256.75 E-value: 1.37e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 250 EQFHELLDELMIGVFIIDTQGRLRLLNPKMQEMLGLSA-KNMQSNYLEVIQDADLIHLIHQVVAEKNSLHQEitvtqgPT 328
Cdd:TIGR02966 6 SRFRAAAQALPDAVVVLDEEGQIEWCNPAAERLLGLRWpDDLGQRITNLIRHPEFVEYLAAGRFSEPLELPS------PI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 329 PLRLDLSLR---YLDDQsandyqVLGIAYDLTRVRQLEKMQKDFVSNVSHELKTPVTSLLGFTETLIDGAKEDPEVLNQF 405
Cdd:TIGR02966 80 NSERVLEIRiapYGEEQ------KLLVARDVTRLRRLEQMRRDFVANVSHELRTPLTVLRGYLETLADGPDEDPEEWNRA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 406 LHIMQKDAQRLQQLIQEILELSR-GSATIPYAEQEITLEKFITEILGSYQQQLAAKQLKTVVHGLPESQFFTKYELFYPI 484
Cdd:TIGR02966 154 LEIMLEQSQRMQSLVEDLLTLSRlESAASPLEDEPVDMPALLDHLRDEAEALSQGKNHQITFEIDGGVDVLGDEDELRSA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 485 VKNLIENAIQYSQENGQITISYAIENQQLRLSVQDTGIGISQKDQERIFERFYRVDKARSRHSGGTGLGLAIVQNYTELL 564
Cdd:TIGR02966 234 FSNLVSNAIKYTPEGGTITVRWRRDGGGAEFSVTDTGIGIAPEHLPRLTERFYRVDKSRSRDTGGTGLGLAIVKHVLSRH 313
|
330 340
....*....|....*....|
gi 488312470 565 GGKIAIDSHLGLGTTFTITL 584
Cdd:TIGR02966 314 HARLEIESELGKGSTFSFIF 333
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
356-588 |
5.10e-71 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 228.25 E-value: 5.10e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 356 LTRVRQLEKMQKDFVSNVSHELKTPVTSLLGFTETLIDGAKEDPEVLNQFLHIMQKDAQRLQQLIQEILELSR-GSATIP 434
Cdd:COG2205 6 LEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRlESGKLS 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 435 YAEQEITLEKFITEILGSYQQQLAAKQLKTVVHGLPES-QFFTKYELFYPIVKNLIENAIQYSQENGQITISYAIENQQL 513
Cdd:COG2205 86 LELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELpLVYADPELLEQVLANLLDNAIKYSPPGGTITISARREGDGV 165
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488312470 514 RLSVQDTGIGISQKDQERIFERFYRVDkaRSRHSGGTGLGLAIVQNYTELLGGKIAIDSHLGLGTTFTITLPLTK 588
Cdd:COG2205 166 RISVSDNGPGIPEEELERIFERFYRGD--NSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLAE 238
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
259-587 |
1.84e-68 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 224.79 E-value: 1.84e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 259 LMIGVFIIDTQGRLRLLNPKMQEMLGLSAKNMQSNYLEVIQDADLIHLIHQVVAEKNSLHQEITVTQGPTPLRLDLSLRY 338
Cdd:COG0642 3 LLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 339 LDDQSANDYQVLGIAYDLTRVRQLEKMQKDFVSNVSHELKTPVTSLLGFTETLIDGAKEDpevLNQFLHIMQKDAQRLQQ 418
Cdd:COG0642 83 LLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEE---QREYLETILRSADRLLR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 419 LIQEILELSR-GSATIPYAEQEITLEKFITEILGSYQQQLAAKQLKTVVHGLPE-SQFFTKYELFYPIVKNLIENAIQYS 496
Cdd:COG0642 160 LINDLLDLSRlEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDlPTVRGDPDRLRQVLLNLLSNAIKYT 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 497 QENGQITISYAIENQQLRLSVQDTGIGISQKDQERIFERFYRVDkaRSRHSGGTGLGLAIVQNYTELLGGKIAIDSHLGL 576
Cdd:COG0642 240 PEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTD--PSRRGGGTGLGLAIVKRIVELHGGTIEVESEPGK 317
|
330
....*....|.
gi 488312470 577 GTTFTITLPLT 587
Cdd:COG0642 318 GTTFTVTLPLA 328
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
223-591 |
4.87e-53 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 186.71 E-value: 4.87e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 223 EWNELYETINLLSQQVSQTYKAYTSADEQFHELLDELMIGVFIIDTQGRLRLLNPKMQEMLGLSAKNMQSNYL-EVIQDA 301
Cdd:COG5000 63 EIGELARAFNRMTDQLKEQREELEERRRYLETILENLPAGVIVLDADGRITLANPAAERLLGIPLEELIGKPLeELLPEL 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 302 DLIHLIHQVVAEknSLHQEITVTQGpTPLRLDLSLRYLDDQSandyQVLGIAyDLTRVRQLEKMQ--KDFVSNVSHELKT 379
Cdd:COG5000 143 DLAELLREALER--GWQEEIELTRD-GRRTLLVRASPLRDDG----YVIVFD-DITELLRAERLAawGELARRIAHEIKN 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 380 PVTSLLGFTETL----IDGAKEDPEVLNQFLHIMQKDAQRLQQLIQEILELSRGSATIPyaeQEITLEKFITEILGSYQQ 455
Cdd:COG5000 215 PLTPIQLSAERLrrklADKLEEDREDLERALDTIIRQVDRLKRIVDEFLDFARLPEPQL---EPVDLNELLREVLALYEP 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 456 QLAAKQLKTVVHGLPESqfftkyelfyPIVK-----------NLIENAIQYSQENGQITISYAIENQQLRLSVQDTGIGI 524
Cdd:COG5000 292 ALKEKDIRLELDLDPDL----------PEVLadrdqleqvliNLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGI 361
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488312470 525 SQKDQERIFERFYrvdkarSRHSGGTGLGLAIVQNYTELLGGKIAIDSHLGLGTTFTITLPLTKKEA 591
Cdd:COG5000 362 PEEVLERIFEPFF------TTKPKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPLAEEAE 422
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
246-591 |
1.56e-51 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 180.81 E-value: 1.56e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 246 TSADEQFHELLDELMIGVFIIDTQGRLRLLNPKMQEMLGLSAKNMQSNYLEVI--QDADLIHLIHQVVAEKNSLHQ-EIT 322
Cdd:COG3852 3 RESEELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELfpEDSPLRELLERALAEGQPVTErEVT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 323 V-TQGPTPLRLDLSLRYLDDQSANDYqVLGIAYDLTR-------VRQLEKMQ--KDFVSNVSHELKTPVTSLLGFTETLI 392
Cdd:COG3852 83 LrRKDGEERPVDVSVSPLRDAEGEGG-VLLVLRDITErkrlereLRRAEKLAavGELAAGLAHEIRNPLTGIRGAAQLLE 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 393 DGAKEDPevLNQFLHIMQKDAQRLQQLIQEILELSRGSatiPYAEQEITLEKFITEILGSYQQQLAAKqlKTVVHGLPES 472
Cdd:COG3852 162 RELPDDE--LREYTQLIIEEADRLNNLVDRLLSFSRPR---PPEREPVNLHEVLERVLELLRAEAPKN--IRIVRDYDPS 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 473 QfftkyelfyPIVK-----------NLIENAIQYSQENGQITISYAIENQ----------QLRLSVQDTGIGISQKDQER 531
Cdd:COG3852 235 L---------PEVLgdpdqliqvllNLVRNAAEAMPEGGTITIRTRVERQvtlgglrprlYVRIEVIDNGPGIPEEILDR 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 532 IFERFYrvdkarSRHSGGTGLGLAIVQNYTELLGGKIAIDSHLGLGTTFTITLPLTKKEA 591
Cdd:COG3852 306 IFEPFF------TTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLEQAEE 359
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
348-585 |
8.64e-46 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 167.11 E-value: 8.64e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 348 QVLGIAYDLTRVRQLEKMQKDFVSNVSHELKTPVTSLLGFTETLIDGAKEDPeVLNQFLHIMQKDAQRLQQLIQEILELS 427
Cdd:PRK11006 186 QLLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQDQPLEGA-LREKALHTMREQTQRMEGLVKQLLTLS 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 428 RGSATIPYAEQEITLEKFITEILGSYQQQLAAKQLKTVVHGLPESQFFTKYELFYPIVKNLIENAIQYSQENGQITISYA 507
Cdd:PRK11006 265 KIEAAPTIDLNEKVDVPMMLRVLEREAQTLSQGKHTITFEVDNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQ 344
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488312470 508 IENQQLRLSVQDTGIGISQKDQERIFERFYRVDKARSRHSGGTGLGLAIVQNYTELLGGKIAIDSHLGLGTTFTITLP 585
Cdd:PRK11006 345 RVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLP 422
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
358-585 |
5.09e-44 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 164.19 E-value: 5.09e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 358 RVRQLEKMQKD---FVSNVSHELKTPVTSLLGFTETLID--GAKEDPEVLnQFLHIMQKDAQRLQQLIQEILELSR-GSA 431
Cdd:COG4251 271 RTAELERSNEEleqFAYVASHDLREPLRKISGFSQLLEEdyGDKLDEEGR-EYLERIRDAAERMQALIDDLLAYSRvGRQ 349
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 432 TIPYaeQEITLEKFITEILGSYQQQLAAKQLKTVVHGLPE-----SQFFtkyELFYpivkNLIENAIQYS--QENGQITI 504
Cdd:COG4251 350 ELEF--EPVDLNELLEEVLEDLEPRIEERGAEIEVGPLPTvrgdpTLLR---QVFQ----NLISNAIKYSrpGEPPRIEI 420
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 505 SYAIENQQLRLSVQDTGIGISQKDQERIFERFYRVDkaRSRHSGGTGLGLAIVQNYTELLGGKIAIDSHLGLGTTFTITL 584
Cdd:COG4251 421 GAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLH--SRDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTL 498
|
.
gi 488312470 585 P 585
Cdd:COG4251 499 P 499
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
243-590 |
1.67e-40 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 153.98 E-value: 1.67e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 243 KAYTSADEQFHELLDELMIGVFIIDTQGRLRLLNPKMQEMLGLSAKN-MQSNYLEVIQDAD---LIHLIHQVVAEKNSLH 318
Cdd:COG5809 134 EALRESEEKFRLIFNHSPDGIIVTDLDGRIIYANPAACKLLGISIEElIGKSILELIHSDDqenVAAFISQLLKDGGIAQ 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 319 QEITVTQGPTPLRLdLSLRY--LDDQSANDYQVlGIAYDLTRVRQLEK-MQK--------DFVSNVSHELKTPVTSLLGF 387
Cdd:COG5809 214 GEVRFWTKDGRWRL-LEASGapIKKNGEVDGIV-IIFRDITERKKLEElLRKseklsvvgELAAGIAHEIRNPLTSLKGF 291
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 388 TETLIDGAKEDPEvlnQFLHIMQKDAQRLQQLIQEILELSRgsatiPyaeQEITLEKF-ITEILGSYQQQLAAKQLKTVV 466
Cdd:COG5809 292 IQLLKDTIDEEQK---TYLDIMLSELDRIESIISEFLVLAK-----P---QAIKYEPKdLNTLIEEVIPLLQPQALLKNV 360
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 467 hglpesQFFTKYELFYPIVK-----------NLIENAIQYSQENGQITIS-YAIENQQLRLSVQDTGIGISQKDQERIFE 534
Cdd:COG5809 361 ------QIELELEDDIPDILgdenqlkqvfiNLLKNAIEAMPEGGNITIEtKAEDDDKVVISVTDEGCGIPEERLKKLGE 434
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 488312470 535 RFYrvdkarSRHSGGTGLGLAIVQNYTELLGGKIAIDSHLGLGTTFTITLPLTKKE 590
Cdd:COG5809 435 PFY------TTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPIKLSE 484
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
484-587 |
5.05e-39 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 138.55 E-value: 5.05e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 484 IVKNLIENAIQYSQENGQITISYAIENQQLRLSVQDTGIGISQKDQERIFERFYRVDKaRSRHSGGTGLGLAIVQNYTEL 563
Cdd:smart00387 9 VLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGLSIVKKLVEL 87
|
90 100
....*....|....*....|....
gi 488312470 564 LGGKIAIDSHLGLGTTFTITLPLT 587
Cdd:smart00387 88 HGGEISVESEPGGGTTFTITLPLE 111
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
358-587 |
1.92e-37 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 142.24 E-value: 1.92e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 358 RVRQLEKM----QkdFVSNVSHELKTPVTSLLGFTETLID--GAKEDPEVLNQFLHIMQKDAQRLQQLIQEILELSRGSA 431
Cdd:COG4191 132 QLVQSEKLaalgE--LAAGIAHEINNPLAAILGNAELLRRrlEDEPDPEELREALERILEGAERAAEIVRSLRAFSRRDE 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 432 TIPyaeQEITLEKFITEILGSYQQQLAAKQLKTVVH---GLP-----ESQFFTkyelfypIVKNLIENAIQ--YSQENGQ 501
Cdd:COG4191 210 EER---EPVDLNELIDEALELLRPRLKARGIEVELDlppDLPpvlgdPGQLEQ-------VLLNLLINAIDamEEGEGGR 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 502 ITISYAIENQQLRLSVQDTGIGISQKDQERIFERFY---RVDKarsrhsgGTGLGLAIVQNYTELLGGKIAIDSHLGLGT 578
Cdd:COG4191 280 ITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFttkPVGK-------GTGLGLSISYGIVEKHGGRIEVESEPGGGT 352
|
....*....
gi 488312470 579 TFTITLPLT 587
Cdd:COG4191 353 TFTITLPLA 361
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
484-584 |
5.83e-37 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 132.73 E-value: 5.83e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 484 IVKNLIENAIQYSQENGQITISYAIENQQLRLSVQDTGIGISQKDQERIFERFYRVDKarSRHSGGTGLGLAIVQNYTEL 563
Cdd:cd00075 4 VLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDK--SREGGGTGLGLAIVRRIVEA 81
|
90 100
....*....|....*....|.
gi 488312470 564 LGGKIAIDSHLGLGTTFTITL 584
Cdd:cd00075 82 HGGRITVESEPGGGTTFTVTL 102
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
363-586 |
6.10e-36 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 140.54 E-value: 6.10e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 363 EKMQKDFVSNVSHELKTPVTSLLGFTETLIDGAKE-DPEVLNQflhiMQKDAQRLQQLIQEILELS---RGSatIPYAEQ 438
Cdd:PRK10549 237 EQMRRDFMADISHELRTPLAVLRGELEAIQDGVRKfTPESVAS----LQAEVGTLTKLVDDLHQLSlsdEGA--LAYRKT 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 439 EITLEKFITEILGSYQQQLAAKQLKTVVHgLPES-----------QFFTkyelfypivkNLIENAIQYSQENGQITISYA 507
Cdd:PRK10549 311 PVDLVPLLEVAGGAFRERFASRGLTLQLS-LPDSatvfgdpdrlmQLFN----------NLLENSLRYTDSGGSLHISAE 379
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 508 IENQQLRLSVQDTGIGISQKDQERIFERFYRVDKARSRHSGGTGLGLAIVQNYTELLGGKI-AIDSHLGlGTTFTITLPL 586
Cdd:PRK10549 380 QRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIiAAHSPFG-GVSITVELPL 458
|
|
| KinD |
COG5808 |
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ... |
360-588 |
6.18e-35 |
|
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444510 [Multi-domain] Cd Length: 454 Bit Score: 137.19 E-value: 6.18e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 360 RQLEKMQKDFVSNVSHELKTPVTSLLGFTETLIDGAKEDPEvlNQFLHIMQKDAQRLQQLIQEILELSRGSATIpyaEQE 439
Cdd:COG5808 235 TQKLELIGTFAASTAHEIRNPLTSIKGFIQLLQEKYPELED--QKYFDIIQEEIQRINQIVSEFLVLGKPTAKK---LEL 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 440 ITLEKFITEILGSYQQQlAAKQLKTVVHGLPESQFFTKYEL--FYPIVKNLIENAIQYSQENGQITISYAIENQQLRLSV 517
Cdd:COG5808 310 DDLNELIEEILSIIDSE-ANLKNIRVEKQSLDEPLHIKCDKdrIKQVLLNLIKNAIEAMKEGGKLTISIENDDEKAVIEV 388
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488312470 518 QDTGIGISQKDQERIFERFYRVDKarsrhsGGTGLGLAIVQNYTELLGGKIAIDSHLGLGTTFTITLPLTK 588
Cdd:COG5808 389 IDNGEGIPEDIIDEIFEPFVTTKE------GGTGLGLSVCKRIVEMHGGEIDIESEEGKGTTFTIRLPLKK 453
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
350-586 |
1.75e-33 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 133.43 E-value: 1.75e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 350 LGIAYDLTRvRQLEKMQ--KDFVSNVSHELKTPVTSLLGFTETLIDGAkeDPEVLNQFLHIMQKDAQRLQQLIQEILELS 427
Cdd:PRK11100 239 LAQALESMR-VKLEGKAyvEQYVQTLTHELKSPLAAIRGAAELLQEDP--PPEDRARFTGNILTQSARLQQLIDRLLELA 315
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 428 R-GSATIPYAEQEITLEKFITEILGSYQQQLAAKQLKTVVHG----LPESQFFTKYELFypivkNLIENAIQYSQENGQI 502
Cdd:PRK11100 316 RlEQRQELEVLEPVALAALLEELVEAREAQAAAKGITLRLRPddarVLGDPFLLRQALG-----NLLDNAIDFSPEGGTI 390
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 503 TISYAIENQQLRLSVQDTGIGISQKDQERIFERFY---RVDKARSrhsgGTGLGLAIVQNYTELLGGKIAIDSHLGLGTT 579
Cdd:PRK11100 391 TLSAEVDGEQVALSVEDQGPGIPDYALPRIFERFYslpRPANGRK----STGLGLAFVREVARLHGGEVTLRNRPEGGVL 466
|
....*..
gi 488312470 580 FTITLPL 586
Cdd:PRK11100 467 ATLTLPR 473
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
362-588 |
2.18e-33 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 133.13 E-value: 2.18e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 362 LEKM---QKDFVSNVSHELKTPVTSLLGFTETLIDGAKEDPEvlnqfLHIMQKDAQRLQQLIQEILELSRGSATIPYAEQ 438
Cdd:PRK09470 236 LERMmtsQQRLLSDISHELRTPLTRLQLATALLRRRQGESKE-----LERIETEAQRLDSMINDLLVLSRNQQKNHLERE 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 439 EITLEKFITEILGSYQQQLAAKQLKTVVHGLPESQF-FTKYELFYPIVKNLIENAIQYSQEngQITISYAIENQQLRLSV 517
Cdd:PRK09470 311 TFKANSLWSEVLEDAKFEAEQMGKSLTVSAPPGPWPiNGNPNALASALENIVRNALRYSHT--KIEVAFSVDKDGLTITV 388
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488312470 518 QDTGIGISQKDQERIFERFYRVDKARSRHSGGTGLGLAIVQNYTELLGGKI-AIDSHLGlGTTFTITLPLTK 588
Cdd:PRK09470 389 DDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVkAEDSPLG-GLRLTIWLPLYK 459
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
484-586 |
3.65e-33 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 122.60 E-value: 3.65e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 484 IVKNLIENAIQYSQEnGQITISYAIENQ-----QLRLSVQDTGIGISQKDQERIFERFYRVDKARSRHSGGTGLGLAIVQ 558
Cdd:cd16922 4 ILLNLLGNAIKFTEE-GEVTLRVSLEEEeedgvQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAISK 82
|
90 100
....*....|....*....|....*...
gi 488312470 559 NYTELLGGKIAIDSHLGLGTTFTITLPL 586
Cdd:cd16922 83 KLVELMGGDISVESEPGQGSTFTFTLPL 110
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
140-590 |
2.69e-31 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 128.55 E-value: 2.69e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 140 PVLKSGEIVGIIRISEQTALFSKNIQSFRRYIIFTFGILFLLITLFIFLLLRQknqpLVTVLPILKRMLKH--PDENRSI 217
Cdd:PRK11360 161 PIERNGEVIGYIWANELTEDIRRQAWKMDRRIYAVLAAGLVIGLLLIFLLSRR----FSANVDIIKDGLSTleNDLSTRL 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 218 IQQSSEWNELYETINLLSQQVSQTyKAYTsadeqfhelldELMI-----GVFIIDTQGRLRLLNPKMQEMLGLSAKNM-Q 291
Cdd:PRK11360 237 PPLPGELGEISQAINNLAQALRET-RSLN-----------ELILesiadGVIAIDRQGKITTMNPAAEVITGLQRHELvG 304
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 292 SNYLEV-IQDADLIHLIHQVVAE-KNSLHQEITVTQGPTPLRLDLSLRYLDDQSANDYQVLGIAYDLT-RVRQLEKMQK- 367
Cdd:PRK11360 305 KPYSELfPPNTPFASPLLDTLEHgTEHVDLEISFPGRDRTIELSVSTSLLHNTHGEMIGALVIFSDLTeRKRLQRRVARq 384
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 368 -------DFVSNVSHELKTPVTSLLGFTETLIDGAKEDPEvlNQFLHIMQKDAQRLQQLIQEILELSRGSATIPyaeQEI 440
Cdd:PRK11360 385 erlaalgELVAGVAHEIRNPLTAIRGYVQIWRQQTSDPPS--QEYLSVVLREVDRLNKVIDQLLEFSRPRESQW---QPV 459
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 441 TLEKFITEILGSYQQqlaakqlktvVHGLPESQFFTKYELFYPIVK-----------NLIENAIQYSQENGQITIS-YAI 508
Cdd:PRK11360 460 SLNALVEEVLQLFQT----------AGVQARVDFETELDNELPPIWadpellkqvllNILINAVQAISARGKIRIRtWQY 529
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 509 ENQQLRLSVQDTGIGISQKDQERIFERFYRVdKARsrhsgGTGLGLAIVQNYTELLGGKIAIDSHLGLGTTFTITLPLTK 588
Cdd:PRK11360 530 SDGQVAVSIEDNGCGIDPELLKKIFDPFFTT-KAK-----GTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINP 603
|
..
gi 488312470 589 KE 590
Cdd:PRK11360 604 QG 605
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
484-588 |
4.34e-31 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 116.70 E-value: 4.34e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 484 IVKNLIENAIQYSQENGQITISyAIENQQLRLSVQDTGIGISQKDQERIFERFYRVDKarsRHSGGTGLGLAIVQNYTEL 563
Cdd:pfam02518 9 VLSNLLDNALKHAAKAGEITVT-LSEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADK---RGGGGTGLGLSIVRKLVEL 84
|
90 100
....*....|....*....|....*
gi 488312470 564 LGGKIAIDSHLGLGTTFTITLPLTK 588
Cdd:pfam02518 85 LGGTITVESEPGGGTTVTLTLPLAQ 109
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
366-585 |
2.58e-29 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 120.96 E-value: 2.58e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 366 QKDFVSNVSHELKTPVTSLLGFTETLIDGAKEDPEvLNQFLHIMQKDAQRLQQLIQEILELSRG-SATIPYAEQEITLEK 444
Cdd:TIGR01386 241 LSQFSADLAHELRTPLTNLLGQTQVALSQPRTGEE-YREVLESNLEELERLSRMVSDMLFLARAdNGQLALERVRLDLAA 319
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 445 FITEILGSYQQQLAAKQLKTVVHGlpESQFFTKYELFYPIVKNLIENAIQYSQENGQITISYAIENQQLRLSVQDTGIGI 524
Cdd:TIGR01386 320 ELAKVAEYFEPLAEERGVRIRVEG--EGLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVRVSVSNPGPGI 397
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488312470 525 SQKDQERIFERFYRVDKARSRHSGGTGLGLAIVQNYTELLGGKIAIDSHLGlGTTFTITLP 585
Cdd:TIGR01386 398 PPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAESPDG-KTRFILRFP 457
|
|
| KinC |
COG5807 |
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ... |
252-586 |
2.00e-28 |
|
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 116.81 E-value: 2.00e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 252 FHELLDELMIGVFIIDTQGRLRLLNPKMQEMLGLSAKNMQSNYL---------EVIQDADLIHLIHQVVAEKNSLHQEIT 322
Cdd:COG5807 29 FKQLFDSILEFVFFIDSKGEILECNDFAEDLYGLSQNEYIGKTFveekcilkdEQLYNKEAFDRIEISYLTKNGEFDEII 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 323 VtqgptplrldlSLRYLDDQsanDYQVLGIAYDLT-------RVRQLEKMQ--KDFVSNVSHELKTPVTSLLGFTEtLID 393
Cdd:COG5807 109 Y-----------PIYYKDGV---ILGLITVYRDITkrkeaedKLLRSEKLSvaGELAAGIAHEIRNPLTSIKGFLQ-LLQ 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 394 GAKEDPEvLNQFLHIMQKDAQRLQQLIQEILELSRgsatipyaEQEITLEKF-ITEILGSYQQQL---AAKQLKTVVHGL 469
Cdd:COG5807 174 ESREDSE-REEYFNIIISEIDRINTIITELLVLSK--------PKKFNFKKLnLNDVLEDVIALLsteAILKNISIKYDL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 470 PESQFFT---KYELfYPIVKNLIENAIQYSQENGQITISYAIENQQLRLSVQDTGIGISQKDQERIFERFYrvdkarSRH 546
Cdd:COG5807 245 ADDEPVIngdKNQL-KQVFINLIKNAIEAMETGGNITIKTYVEGDFVVISVKDEGIGIPEEVLEKIGEPFF------TTK 317
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 488312470 547 SGGTGLGLAIVQNYTELLGGKIAIDSHLGLGTTFTITLPL 586
Cdd:COG5807 318 EEGTGLGLSICKKIIEEHNGTIEVESKPGKGTTFTIYLPL 357
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
487-585 |
5.13e-28 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 108.06 E-value: 5.13e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 487 NLIENAIQYSQENGQITISYAIENQQLRLSVQDTGIGISQKDQERIFERFYRVDKARSRHSGGTGLGLAIVQNYTELLGG 566
Cdd:cd16952 7 NLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHVMSRHDA 86
|
90
....*....|....*....
gi 488312470 567 KIAIDSHLGLGTTFTITLP 585
Cdd:cd16952 87 RLLIASELGKGSRFTCLFP 105
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
373-585 |
8.23e-27 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 112.35 E-value: 8.23e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 373 VSHELKTPVTSLLGFTETLIDGAKED-----PEVLNQFLHIMQKDAQRLQQLIQEILELSRGSAT-IPYAEQEITLEKFI 446
Cdd:PRK09303 158 LAHDLRTPLTAASLALETLELGQIDEdtelkPALIEQLQDQARRQLEEIERLITDLLEVGRTRWEaLRFNPQKLDLGSLC 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 447 TEILGSYQQQLAAKQLKT---VVHGLPEsqFFTKYELFYPIVKNLIENAIQYSQENGQITISyAIE--NQQLRLSVQDTG 521
Cdd:PRK09303 238 QEVILELEKRWLAKSLEIqtdIPSDLPS--VYADQERIRQVLLNLLDNAIKYTPEGGTITLS-MLHrtTQKVQVSICDTG 314
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488312470 522 IGISQKDQERIFERFYRVDkaRSRHSGGTGLGLAIVQNYTELLGGKIAIDSHLGLGTTFTITLP 585
Cdd:PRK09303 315 PGIPEEEQERIFEDRVRLP--RDEGTEGYGIGLSVCRRIVRVHYGQIWVDSEPGQGSCFHFTLP 376
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
484-585 |
1.42e-26 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 104.08 E-value: 1.42e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 484 IVKNLIENAIQYSQENGQITISYAIENQQLRLSVQDTGIGISQKDQERIFERFYRVDKARSRHSGGTGLGLAIVQNYTEL 563
Cdd:cd16946 8 LFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAICHNIALA 87
|
90 100
....*....|....*....|...
gi 488312470 564 LGGKIAID-SHLGlGTTFTITLP 585
Cdd:cd16946 88 HGGTISAEhSPLG-GLRLVLTLP 109
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
250-587 |
1.68e-26 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 113.29 E-value: 1.68e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 250 EQFHELLDELMI-GVFIIDTQGRLRLLNPKMQEMLGLSAKN-MQSNYLEVIQDADLIHLIH--QVVAEKnslHQEITVTQ 325
Cdd:COG5805 156 EERLQTLIENSPdLICVIDTDGRILFINESIERLFGAPREElIGKNLLELLHPCDKEEFKEriESITEV---WQEFIIER 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 326 gpTPLRLDLSLRYL---------DDQSANDYQVlgIAYDLTRVRQLEKM--QKDFVS-------NVSHELKTPVTSLLGF 387
Cdd:COG5805 233 --EIITKDGRIRYFeavivplidTDGSVKGILV--ILRDITEKKEAEELmaRSEKLSiagqlaaGIAHEIRNPLTSIKGF 308
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 388 TeTLIDGAKEDPEvlnQFLHIMQKDAQRLQQLIQEILELSRGSAtipYAEQEITLEKFITEILGSYQQQLAAKQLKTVVH 467
Cdd:COG5805 309 L-QLLQPGIEDKE---EYFDIMLSELDRIESIISEFLALAKPQA---VNKEKENINELIQDVVTLLETEAILHNIQIRLE 381
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 468 GLPESQFFT--KYELFYPIVkNLIENAIQYSQENGQITISYAIENQQLRLSVQDTGIGISQKDQERIFERFYrvdkarSR 545
Cdd:COG5805 382 LLDEDPFIYcdENQIKQVFI-NLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPFF------TT 454
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 488312470 546 HSGGTGLGLAIVQNYTELLGGKIAIDSHLGLGTTFTITLPLT 587
Cdd:COG5805 455 KEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPLS 496
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
487-586 |
3.49e-25 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 100.09 E-value: 3.49e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 487 NLIENAIQYSqeNGQITISYAIENQQLRLSVQDTGIGISQKDQERIFERFYRVDKARSRHSGGTGLGLAIVQNYTELLGG 566
Cdd:cd16949 7 NVLRNALRYS--PSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERAIEQHGG 84
|
90 100
....*....|....*....|.
gi 488312470 567 KI-AIDSHLGlGTTFTITLPL 586
Cdd:cd16949 85 KIkASNRKPG-GLRVRIWLPA 104
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
355-586 |
5.90e-25 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 109.94 E-value: 5.90e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 355 DLTRVRQLE--KMQKDFVSNVSHELKTPVTSLLGFTETLIdgakEDPEVLNQ--FLHIMQKDAQRLQQLIQEILELSRGS 430
Cdd:PRK11107 280 DLAKKRAQEaaRIKSEFLANMSHELRTPLNGVIGFTRQTL----KTPLTPTQrdYLQTIERSANNLLAIINDILDFSKLE 355
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 431 A------TIPYAEQEiTLEKFITEILGSYQqqlaAKQLKTVV---HGLPE---------SQfftkyelfypIVKNLIENA 492
Cdd:PRK11107 356 AgklvleNIPFSLRE-TLDEVVTLLAHSAH----EKGLELTLnidPDVPDnvigdplrlQQ----------IITNLVGNA 420
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 493 IQYSqENGQITISY---AIENQQLRLSVQ--DTGIGISQKDQERIFERFYRVDKARSRHSGGTGLGLAIVQNYTELLGGK 567
Cdd:PRK11107 421 IKFT-ESGNIDILVelrALSNTKVQLEVQirDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVITQKLVNEMGGD 499
|
250
....*....|....*....
gi 488312470 568 IAIDSHLGLGTTFTITLPL 586
Cdd:PRK11107 500 ISFHSQPNRGSTFWFHLPL 518
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
360-587 |
1.83e-24 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 108.58 E-value: 1.83e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 360 RQLEKMQK---DFVSNVSHELKTPVTSLLGFTEtLIDGAKEDPEVLnQFLHIMQKDAQRLQQLIQEILELSRgsatIPYA 436
Cdd:PRK15347 389 QRAEQANKrksEHLTTISHEIRTPLNGVLGALE-LLQNTPLTAEQM-DLADTARQCTLSLLAIINNLLDFSR----IESG 462
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 437 EQEITLEKfiTEILGSYQQQLAAKQLKTVVHGLPESQFFTKY--ELFY-------PIVKNLIENAIQYSqENGQITISYA 507
Cdd:PRK15347 463 QMTLSLEE--TALLPLLDQAMLTIQGPAQSKSLTLRTFVGAHvpLYLHldslrlrQILVNLLGNAVKFT-ETGGIRLRVK 539
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 508 IENQQLRLSVQDTGIGISQKDQERIFERFYRVDKarsrHSGGTGLGLAIVQNYTELLGGKIAIDSHLGLGTTFTITLPLT 587
Cdd:PRK15347 540 RHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADT----HSQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLPLN 615
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
363-588 |
6.03e-24 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 107.04 E-value: 6.03e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 363 EKMQKDFVSNVSHELKTPVTSLLGFTETL-IDGAKEDPEvlnqflHIMQKDAQRLQ-----QLIQEILELSR-GSATIPY 435
Cdd:PRK10490 661 EQLRNALLAALSHDLRTPLTVLFGQAEILtLDLASEGSP------HARQASEIRQQvlnttRLVNNLLDMARiQSGGFNL 734
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 436 AEQEITLEkfitEILGSYQQQLAAKQLKTVVH-GLPESQFFTKYE--LFYPIVKNLIENAIQYSQENGQITISYAIENQQ 512
Cdd:PRK10490 735 RKEWLTLE----EVVGSALQMLEPGLSGHPINlSLPEPLTLIHVDgpLFERVLINLLENAVKYAGAQAEIGIDAHVEGER 810
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488312470 513 LRLSVQDTGIGISQKDQERIFERFYRVDKARSrhSGGTGLGLAIVQNYTELLGGKIAIDSHLGLGTTFTITLPLTK 588
Cdd:PRK10490 811 LQLDVWDNGPGIPPGQEQLIFDKFARGNKESA--IPGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLPLET 884
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
227-589 |
3.42e-23 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 101.85 E-value: 3.42e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 227 LYETINLLSQQVSQTYKAYTSADEQFHELLDELMIGVFIIDTQGRLRLLNPKMQEMLGLSAKNMQSNYLEVIQDADLIHL 306
Cdd:COG3290 61 LLLLLLLLAALLLKLLEEIARLVEEREAVLESIREGVIAVDRDGRITLINDAARRLLGLDAIGRPIDEVLAEVLETGERD 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 307 IHQVVAEKNSLHQEITVTQGPTPLRLDLSLRYLDDQSAndyqvlgiaydltRVRQLEKMQKdFVSNV---SHELKTPVTS 383
Cdd:COG3290 141 EEILLNGRVLVVNRVPIRDDGRVVGAVATFRDRTELER-------------LEEELEGVKE-LAEALraqRHDFRNHLHT 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 384 LLGFTETlidgakEDPEVLNQFLhimQKDAQRLQQLIQEILELSRgsatipyaeqeitlEKFITEILGSYQQQLAAK--Q 461
Cdd:COG3290 207 ISGLLQL------GEYDEALEYI---DEISEELQELIDSLLSRIG--------------NPVLAALLLGKAARARERgiD 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 462 LKTVVHGLPESQFFTKYELFYpIVKNLIENAIQYSQ----ENGQITISYAIENQQLRLSVQDTGIGISQKDQERIFERFY 537
Cdd:COG3290 264 LTIDIDSDLPDLPLSDTDLVT-ILGNLLDNAIEAVEklpeEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGF 342
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 488312470 538 RvdkarSRHSGGTGLGLAIVQNYTELLGGKIAIDSHLGLGTTFTITLPLTKK 589
Cdd:COG3290 343 S-----TKLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEGE 389
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
373-586 |
3.42e-23 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 102.94 E-value: 3.42e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 373 VSHELKTPVTSLLGFTETLIDGAKEDPEVlNQFLHIMQKDAQRLQQLIQEILELSRGSATIPyaeQEITLEKFITEILGS 452
Cdd:PRK10364 244 VAHEIRNPLSSIKGLAKYFAERAPAGGEA-HQLAQVMAKEADRLNRVVSELLELVKPTHLAL---QAVDLNDLINHSLQL 319
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 453 YQQQLAAKQLK---TVVHGLPESQffTKYELFYPIVKNLIENAIQYSQENGQITISYAIENQQLRLSVQDTGIGISQKDQ 529
Cdd:PRK10364 320 VSQDANSREIQlrfTANDTLPEIQ--ADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAADQL 397
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 488312470 530 ERIFERFYrVDKARsrhsgGTGLGLAIVQNYTELLGGKIAIDSHLGLGTTFTITLPL 586
Cdd:PRK10364 398 EAIFTPYF-TTKAE-----GTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPV 448
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
487-585 |
3.44e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 94.38 E-value: 3.44e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 487 NLIENAIQYSQENGQITISYAIENQQLRLSVQDTGIGISQKDQERIFERFYRVDKarSRHSGGTGLGLAIVQNYTELLGG 566
Cdd:cd16923 7 NLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDN--SRNTEGAGLGLSIAKAIIELHGG 84
|
90
....*....|....*....
gi 488312470 567 KIAIDShLGLGTTFTITLP 585
Cdd:cd16923 85 SASAEY-DDNHDLFKVRLP 102
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
487-585 |
7.37e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 93.55 E-value: 7.37e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 487 NLIENAIQYS--QENGQITISYAIENQQLRLSVQDTGIGISQKDQERIFERFYRVDkarSRH-SGGTGLGLAIVQNYTEL 563
Cdd:cd16921 7 NLLGNAIKFRrpRRPPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLH---SREeYEGTGVGLAIVRKIIER 83
|
90 100
....*....|....*....|..
gi 488312470 564 LGGKIAIDSHLGLGTTFTITLP 585
Cdd:cd16921 84 HGGRIWLESEPGEGTTFYFTLP 105
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
226-586 |
7.79e-23 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 103.10 E-value: 7.79e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 226 ELYETINLLSQQVSQTYKAytsaDEQFHELLDELMIGVF------------------IIDT----------QGRLRLLNP 277
Cdd:PRK11091 107 QLKDNIAQLNQEIAEREKA----EEARQEAFEQLKNEIKereetqieleqqssllrsFLDAspdlvyyrneDGEFSGCNR 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 278 KMQEMLGLSAKnmqsnyleviqdaDLIHLIHQVVAEKNSLHQEIT----VTQGPTPLRLDLSLRYLD------------- 340
Cdd:PRK11091 183 AMELLTGKSEK-------------QLIGLTPKDVYSPEAAEKVIEtdekVFRHNVSLTYEQWLDYPDgrkacfelrkvpf 249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 341 -DQSANDYQVLGIAYDLTRVRQ----LEKMQKD---FVSNVSHELKTPVTSLLGFTETLIDgAKEDPEVLNQfLHIMQKD 412
Cdd:PRK11091 250 yDRVGKRHGLMGFGRDITERKRyqdaLEKASRDkttFISTISHELRTPLNGIVGLSRILLD-TELTAEQRKY-LKTIHVS 327
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 413 AQRLQQLIQEILELSR-GSATIPYAEQEITLEKFITEILGSYQQQLAAKQLKTVVHglPESQFFTKYEL----FYPIVKN 487
Cdd:PRK11091 328 AITLGNIFNDIIDMDKmERRKLQLDNQPIDFTDFLADLENLSGLQAEQKGLRFDLE--PLLPLPHKVITdgtrLRQILWN 405
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 488 LIENAIQYSQEnGQITISYAIE-NQQLRLSVQDTGIGISQKDQERIFERFYRV-DKARSRHSGGTGLGLAIVQNYTELLG 565
Cdd:PRK11091 406 LISNAVKFTQQ-GGVTVRVRYEeGDMLTFEVEDSGIGIPEDELDKIFAMYYQVkDSHGGKPATGTGIGLAVSKRLAQAMG 484
|
410 420
....*....|....*....|.
gi 488312470 566 GKIAIDSHLGLGTTFTITLPL 586
Cdd:PRK11091 485 GDITVTSEEGKGSCFTLTIHA 505
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
350-586 |
1.03e-22 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 101.22 E-value: 1.03e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 350 LGIAYD--LTRVRQLEKMQKDFVSNVSHELKTPVTSLLGFTETLIDGAKEDPEVLNqflhimqKDAQRLQQLIQEILELS 427
Cdd:PRK10604 194 LGVAFNqmADNINALIASKKQLIDGIAHELRTPLVRLRYRLEMSDNLSAAESQALN-------RDIGQLEALIEELLTYA 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 428 R-GSATIPYAEQEITLEKFITEILGSYQQQLAAKQLKTVVhgLPESQFFTKYE-LFYPIVKNLIENAIQYSqeNGQITIS 505
Cdd:PRK10604 267 RlDRPQNELHLSEPDLPAWLSTHLADIQAVTPEKTVRLDT--PHQGDYGALDMrLMERVLDNLLNNALRYA--HSRVRVS 342
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 506 YAIENQQLRLSVQDTGIGISQKDQERIFERFYRVDKARSRHSGGTGLGLAIVQNYTELLGGKIAID-SHLGlGTTFTITL 584
Cdd:PRK10604 343 LLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDeSELG-GARFSFSW 421
|
..
gi 488312470 585 PL 586
Cdd:PRK10604 422 PV 423
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
369-586 |
4.30e-22 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 101.20 E-value: 4.30e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 369 FVSNVSHELKTPVTSLLGFTETLidGAKEDPEVLNQFLHIMQKDAQRLQQLIQEILELSRgsatIPYAEQEITLEKF--- 445
Cdd:PRK10841 450 FLATVSHELRTPLYGIIGNLDLL--QTKELPKGVDRLVTAMNNSSSLLLKIISDILDFSK----IESEQLKIEPREFspr 523
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 446 --ITEILGSYQQQLAAKQLKT---VVHGLPESQFFTKYELfYPIVKNLIENAIQYSqENGQITISYAIENQQLRLSVQDT 520
Cdd:PRK10841 524 evINHITANYLPLVVKKRLGLycfIEPDVPVALNGDPMRL-QQVISNLLSNAIKFT-DTGCIVLHVRVDGDYLSFRVRDT 601
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488312470 521 GIGISQKDQERIFERFYRVDKARSRHSGGTGLGLAIVQNYTELLGGKIAIDSHLGLGTTFTITLPL 586
Cdd:PRK10841 602 GVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLINMMDGDISVDSEPGMGSQFTIRIPL 667
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
366-586 |
9.01e-22 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 100.19 E-value: 9.01e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 366 QKDFVSNVSHELKTPVTSLLGFTEtLIDGAKEDPEVLNQFLHIMQKDAQRLQQLIQEILELSR-GSATIPYAEQEITLEK 444
Cdd:PRK09959 712 KSQFLATMSHEIRTPISSIMGFLE-LLSGSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKiESGNYQLQPQWVDIPT 790
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 445 FITEILGSYQQQLAAKQLKTVVHGLPESQFFTKY--ELFYPIVKNLIENAIQYSQEnGQITISYAI-----ENQQLRLSV 517
Cdd:PRK09959 791 LVQNTCHSFGAIAASKSIALSCSSTFPDHYLVKIdpQAFKQVLSNLLSNALKFTTE-GAVKITTSLghiddNHAVIKMTI 869
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488312470 518 QDTGIGISQKDQERIFERFYRVDKARSRhsGGTGLGLAIVQNYTELLGGKIAIDSHLGLGTTFTITLPL 586
Cdd:PRK09959 870 MDSGSGLSQEEQQQLFKRYSQTSAGRQQ--TGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIPV 936
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
484-585 |
1.09e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 90.04 E-value: 1.09e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 484 IVKNLIENAIQYSQENGQITISYAIENQQLRLSVQDTGIGISQKDQERIFERFYRVDKARsRHSGGTGLGLAIVQNYTEL 563
Cdd:cd16948 9 IIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGR-NFQESTGMGLYLVKKLCDK 87
|
90 100
....*....|....*....|..
gi 488312470 564 LGGKIAIDSHLGLGTTFTITLP 585
Cdd:cd16948 88 LGHKIDVESEVGEGTTFTITFP 109
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
485-586 |
1.25e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 89.80 E-value: 1.25e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 485 VKNLIENAIQYSQEngQITISYAIENQQLRLSVQDTGIGISQKDQERIFERFYRVDKARSRHSGGTGLGLAIVQNYTELL 564
Cdd:cd16939 5 LDNLLRNALRYAHR--TVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRVALWH 82
|
90 100
....*....|....*....|...
gi 488312470 565 GGKIAI-DSHLGlGTTFTITLPL 586
Cdd:cd16939 83 GGHVECdDSELG-GACFRLTWPR 104
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
358-591 |
4.74e-21 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 97.83 E-value: 4.74e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 358 RVRQLEKMQK--DFVSNVSHELKTPVTSLLGFTEtlIDGAKEDPE-VLNQFLHIMQKDAQRLQQLIQEILELSRGSatiP 434
Cdd:PRK13837 440 RLEHARRLEAvgTLASGIAHNFNNILGAILGYAE--MALNKLARHsRAARYIDEIISAGARARLIIDQILAFGRKG---E 514
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 435 YAEQEITLEKFITEILGSYQQQLAA--------KQLKTVVHGLPEsqfftkyELfYPIVKNLIENAIQYSQENGQITIS- 505
Cdd:PRK13837 515 RNTKPFDLSELVTEIAPLLRVSLPPgveldfdqDQEPAVVEGNPA-------EL-QQVLMNLCSNAAQAMDGAGRVDISl 586
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 506 YAIENQQ--------------LRLSVQDTGIGISQKDQERIFERFYrvdkarSRHSGGTGLGLAIVQNYTELLGGKIAID 571
Cdd:PRK13837 587 SRAKLRApkvlshgvlppgryVLLRVSDTGAGIDEAVLPHIFEPFF------TTRAGGTGLGLATVHGIVSAHAGYIDVQ 660
|
250 260
....*....|....*....|
gi 488312470 572 SHLGLGTTFTITLPLTKKEA 591
Cdd:PRK13837 661 STVGRGTRFDVYLPPSSKVP 680
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
484-585 |
8.62e-21 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 87.55 E-value: 8.62e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 484 IVKNLIENAIQYSQENGQITISYAI-ENQQLRLSVQDTGIGISQKDQERIFERFYRVDKARSRHSGGTGLGLAIVQNYTE 562
Cdd:cd16925 8 VVLNLLSNAFKFTPDGGRIRCILEKfRLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLSIVKEFVE 87
|
90 100
....*....|....*....|...
gi 488312470 563 LLGGKIAIDSHLGLGTTFTITLP 585
Cdd:cd16925 88 LHGGTVTVSDAPGGGALFQVELP 110
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
484-584 |
1.74e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 87.18 E-value: 1.74e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 484 IVKNLIENAIQYSQENGQITISYAIENQQLRLSVQDTGIGISQKDQERIFERFYRVDKARSRHSGGTGLGLAIVQNYTEL 563
Cdd:cd16947 24 ILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAKQGNGLGLTITKRLAES 103
|
90 100
....*....|....*....|.
gi 488312470 564 LGGKIAIDSHLGLGTTFTITL 584
Cdd:cd16947 104 MGGSIYVNSKPYEKTVFTVTL 124
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
484-586 |
3.38e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 85.94 E-value: 3.38e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 484 IVKNLIENAIQYSQENGQITISYAIENQQLRLSVQDTGIGISQKDQERIFERFYRVDKARSrhsgGTGLGLAIVQNYTEL 563
Cdd:cd16943 7 VLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGE----GTGLGLSLSYRIIQK 82
|
90 100
....*....|....*....|...
gi 488312470 564 LGGKIAIDSHLGLGTTFTITLPL 586
Cdd:cd16943 83 HGGTIRVASVPGGGTRFTIILPI 105
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
484-585 |
9.11e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 84.65 E-value: 9.11e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 484 IVKNLIENAIQYS----QENGQITISYAIENQQLRLSVQDTGIGISQKDQERIFERFYRvdkarSRHSGGTGLGLAIVQN 559
Cdd:cd16915 4 IVGNLIDNALDALaatgAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVS-----TKGQGERGIGLALVRQ 78
|
90 100
....*....|....*....|....*.
gi 488312470 560 YTELLGGKIAIDSHLGLGTTFTITLP 585
Cdd:cd16915 79 SVERLGGSITVESEPGGGTTFSIRIP 104
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
480-584 |
6.58e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 82.45 E-value: 6.58e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 480 LFYPIVKNLIENAIQYSQENGQITIsyAIENQQL-RLSVQDTGIGISQKDQERIFERFYRVDKarsRHSGGTGLGLAIVQ 558
Cdd:cd16940 13 LLFLLLRNLVDNAVRYSPQGSRVEI--KLSADDGaVIRVEDNGPGIDEEELEALFERFYRSDG---QNYGGSGLGLSIVK 87
|
90 100
....*....|....*....|....*.
gi 488312470 559 NYTELLGGKIAIDSHLGLGTTFTITL 584
Cdd:cd16940 88 RIVELHGGQIFLGNAQGGGLEAWVRL 113
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
321-585 |
3.75e-18 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 87.52 E-value: 3.75e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 321 ITVTQGPTPLR-----------LDLSLRYLDDQSANDYQVLGIAYD--LTRVRQLEKMQKDFVSNVSHELKTPVTSLLGF 387
Cdd:PRK09835 204 LAVHKGHAPIRsvsrqiqnitsKDLDVRLDPQTVPIELEQLVLSFNhmIERIEDVFTRQSNFSADIAHEIRTPITNLITQ 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 388 TETLIDGAKEDPEvLNQFLHIMQKDAQRLQQLIQEILELSRGSAT--IPyAEQEITLEKFITEILGSYQQQLAAKQLKTV 465
Cdd:PRK09835 284 TEIALSQSRSQKE-LEDVLYSNLEELTRMAKMVSDMLFLAQADNNqlIP-EKKMLDLADEVGKVFDFFEAWAEERGVELR 361
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 466 VHGLPeSQFFTKYELFYPIVKNLIENAIQYSQENGQITISYAIENQQLRLSVQDTGIGISQKDQERIFERFYRVDKARSR 545
Cdd:PRK09835 362 FVGDP-CQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQR 440
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 488312470 546 HSGGTGLGLAIVQNYTELLGGKIAIDSHLgLGTTFTITLP 585
Cdd:PRK09835 441 KGEGSGIGLAIVKSIVVAHKGTVAVTSDA-RGTRFVISLP 479
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
484-590 |
5.48e-18 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 87.28 E-value: 5.48e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 484 IVKNLIENAIQY--SQENGQITISYAIENQQLRLSVQDTGIGISQKDQERIFERFYrvdkarSRHSGGTGLGLAIVQNYT 561
Cdd:PRK11086 437 ILGNLIENALEAvgGEEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGY------STKGSNRGVGLYLVKQSV 510
|
90 100
....*....|....*....|....*....
gi 488312470 562 ELLGGKIAIDSHLGLGTTFTITLPLTKKE 590
Cdd:PRK11086 511 ENLGGSIAVESEPGVGTQFFVQIPWDGER 539
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
484-585 |
2.05e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 77.87 E-value: 2.05e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 484 IVKNLIENAIQYSqeNGQITISYAIENQQLRLSVQDTGIGISQKDQERIFERFYRVDKARSrhSGGTGLGLAIVQNYTEL 563
Cdd:cd16950 4 VLSNLVDNALRYG--GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARG--TSGTGLGLAIVQRISDA 79
|
90 100
....*....|....*....|..
gi 488312470 564 LGGKIAIDSHLGLGTTFTITLP 585
Cdd:cd16950 80 HGGSLTLANRAGGGLCARIELP 101
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
359-587 |
2.29e-17 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 84.58 E-value: 2.29e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 359 VRQLEKMQKDFVSNVSHELKTPVTSLLGFTET-------LIDGAKEDPE----VLNQFLHIMQKDAQ------RLQQLIQ 421
Cdd:PRK09467 222 IKQLEDDRTLLMAGVSHDLRTPLTRIRLATEMmseedgyLAESINKDIEecnaIIEQFIDYLRTGQEmpmemaDLNALLG 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 422 EILelsrgSATIPYaEQEITLEkFITEILGSYQQQLAAKQlktvvhglpesqfftkyelfypIVKNLIENAIQYSqeNGQ 501
Cdd:PRK09467 302 EVI-----AAESGY-EREIETA-LQPGPIEVPMNPIAIKR----------------------ALANLVVNAARYG--NGW 350
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 502 ITISYAIENQQLRLSVQDTGIGISQKDQERIFERFYRVDKARSrhSGGTGLGLAIVQNYTELLGGKIAIDSHLGLGTTFT 581
Cdd:PRK09467 351 IKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARG--SSGTGLGLAIVKRIVDQHNGKVELGNSEEGGLSAR 428
|
....*.
gi 488312470 582 ITLPLT 587
Cdd:PRK09467 429 AWLPLT 434
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
356-585 |
8.34e-17 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 84.02 E-value: 8.34e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 356 LTRVRQLEKMQKDFVSNVSHELKTPV----TSL----LGFTETL----IDGAKEDPEVLNQFLHIMqKDAQRLQQLIQEi 423
Cdd:TIGR03785 475 VARLRQYTHYLENMSSRLSHELRTPVavvrSSLenleLQALEQEkqkyLERAREGTERLSMILNNM-SEATRLEQAIQS- 552
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 424 lelsrgsatipyAEQE-ITLEKFITEILGSYQQQLAAKQLK-------TVVHGLPesqfftkyELFYPIVKNLIENAIQY 495
Cdd:TIGR03785 553 ------------AEVEdFDLSEVLSGCMQGYQMTYPPQRFElnipetpLVMRGSP--------ELIAQMLDKLVDNAREF 612
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 496 SQENGQITISYAIENQQLRLSVQDTGIGISQKDQERIFERFY--RVDKARSRHSggTGLGLAIVQNYTELLGGKI-AIDS 572
Cdd:TIGR03785 613 SPEDGLIEVGLSQNKSHALLTVSNEGPPLPEDMGEQLFDSMVsvRDQGAQDQPH--LGLGLYIVRLIADFHQGRIqAENR 690
|
250
....*....|...
gi 488312470 573 HLGLGTTFTITLP 585
Cdd:TIGR03785 691 QQNDGVVFRISLP 703
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
484-585 |
7.83e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 73.76 E-value: 7.83e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 484 IVKNLIENAIQYS-QENGQITISYAIENQQLRLSVQDTGIGISQKDQERIFERFYRVDKARSRHSGGTGLGLAIVQNYTE 562
Cdd:cd16953 4 VLRNLIGNAISFSpPDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQHSGLGLSISRQIIE 83
|
90 100
....*....|....*....|....*..
gi 488312470 563 LLGGKIAIDSH----LGLGTTFTITLP 585
Cdd:cd16953 84 AHGGISVAENHnqpgQVIGARFTVQLP 110
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
369-565 |
4.36e-15 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 77.77 E-value: 4.36e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 369 FVSNVSHELKTPVTSLLGFTEtLIDGAKEDPEVLNQFLHIMQKDAQRLQQLIQEILELSR--------GSATIPYAEqei 440
Cdd:PRK10337 240 FTSDAAHELRSPLAALKVQTE-VAQLSDDDPQARKKALLQLHAGIDRATRLVDQLLTLSRldsldnlqDVAEIPLED--- 315
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 441 TLEKFITEILGSYQQ-------QLAAKQLKTVVHGLpesqfftkyeLFYPIVKNLIENAIQYSQENGQITISYAIEnqql 513
Cdd:PRK10337 316 LLQSAVMDIYHTAQQagidvrlTLNAHPVIRTGQPL----------LLSLLVRNLLDNAIRYSPQGSVVDVTLNAR---- 381
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 488312470 514 RLSVQDTGIGISQKDQERIFERFYRvdkARSRHSGGTGLGLAIVQNYTELLG 565
Cdd:PRK10337 382 NFTVRDNGPGVTPEALARIGERFYR---PPGQEATGSGLGLSIVRRIAKLHG 430
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
479-570 |
4.71e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 71.34 E-value: 4.71e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 479 ELFYPIVKNLIENAIQYSQENGQITISYAIENQQLRLSVQDTGIGISQKDQERIFERFYRVDKarSRHSGG-TGLGLAIV 557
Cdd:cd16975 3 LLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDT--SRRSGGhYGMGLYIA 80
|
90
....*....|...
gi 488312470 558 QNYTELLGGKIAI 570
Cdd:cd16975 81 KNLVEKHGGSLII 93
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
369-586 |
1.02e-14 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 77.64 E-value: 1.02e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 369 FVSNVSHELKTPVTSLLGFTETLIDgakeDPEVLNQ--FLHIMQKDAQRLQQLIQEILELSR---GSATIPYAEQEITLE 443
Cdd:PRK11466 447 FLAAMSHEIRTPLYGILGTAQLLAD----NPALNAQrdDLRAITDSGESLLTILNDILDYSAieaGGKNVSVSDEPFEPR 522
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 444 KFITEIL----GSYQQQLA------AKQLKTVVHGLPESqfftkyelFYPIVKNLIENAIQYSqENGQITISYAIENQQL 513
Cdd:PRK11466 523 PLLESTLqlmsGRVKGRPIrlatdiADDLPTALMGDPRR--------IRQVITNLLSNALRFT-DEGSIVLRSRTDGEQW 593
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488312470 514 RLSVQDTGIGISQKDQERIFERFYRVDKARsrhsGGTGLGLAIVQNYTELLGGKIAIDSHLGLGTTFTITLPL 586
Cdd:PRK11466 594 LVEVEDSGCGIDPAKLAEIFQPFVQVSGKR----GGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPL 662
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
484-585 |
1.10e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 70.12 E-value: 1.10e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 484 IVKNLIENAIQYSQENGQITISYAI-ENQQLRLSVQDTGIGISQKDQERIFERFYrvdkarSRHSGGTGLGLAIVQNYTE 562
Cdd:cd16920 8 LVRNGIEAMSEGGCERRELTIRTSPaDDRAVTISVKDTGPGIAEEVAGQLFDPFY------TTKSEGLGMGLSICRSIIE 81
|
90 100
....*....|....*....|...
gi 488312470 563 LLGGKIAIDSHLGLGTTFTITLP 585
Cdd:cd16920 82 AHGGRLSVESPAGGGATFQFTLP 104
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
365-428 |
1.32e-14 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 68.39 E-value: 1.32e-14
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488312470 365 MQKDFVSNVSHELKTPVTSLLGFTETLIDGakEDPEVLNQFLHIMQKDAQRLQQLIQEILELSR 428
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDE--KLDEEQREYLETILRSAERLLRLINDLLDLSR 62
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
487-585 |
1.83e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 69.72 E-value: 1.83e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 487 NLIENAIQYSQENGQITISYA---------------IENQQLRLSVQDTGIGISQKDQERIFERFYRVDKARSrhsgGTG 551
Cdd:cd16919 7 NLAVNARDAMPEGGRLTIETSnqrvdadyalnyrdlIPGNYVCLEVSDTGSGMPAEVLRRAFEPFFTTKEVGK----GTG 82
|
90 100 110
....*....|....*....|....*....|....
gi 488312470 552 LGLAIVQNYTELLGGKIAIDSHLGLGTTFTITLP 585
Cdd:cd16919 83 LGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
470-584 |
1.99e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 70.35 E-value: 1.99e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 470 PESQFFTKYELFYPIVKNLIENAIQYSqeNGQITISYAIENQQLRLSVQDTGIGISQKDQERIFERFYRVDKARSrhsgG 549
Cdd:cd16954 27 PELRFPGERNDLMELLGNLLDNACKWC--LEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLDEQRP----G 100
|
90 100 110
....*....|....*....|....*....|....*.
gi 488312470 550 TGLGLAIVQNYTELLGGKIAI-DSHLGlGTTFTITL 584
Cdd:cd16954 101 QGLGLAIAKEIVEQYGGELSLsDSPLG-GARFEVVF 135
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
363-428 |
2.62e-14 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 67.62 E-value: 2.62e-14
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488312470 363 EKMQKDFVSNVSHELKTPVTSLLGFTETLIDGAKEDPEvLNQFLHIMQKDAQRLQQLIQEILELSR 428
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEE-QREYLERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
485-570 |
2.86e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 69.03 E-value: 2.86e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 485 VKNLIENAIQYSQENGQITISYAIENQQLRLSVQDTGIGISQKDQERIFERFYRVDKArsrHSG--GTGLGLAIVQNYTE 562
Cdd:cd16945 9 INNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRP---HSGqkSTGLGLAFVQEVAQ 85
|
....*...
gi 488312470 563 LLGGKIAI 570
Cdd:cd16945 86 LHGGRITL 93
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
369-573 |
4.55e-14 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 73.85 E-value: 4.55e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 369 FVSNVSHELKTPvtsLLGFTETLidgakedpEVLNQfLHIMQKDA--QRLQQL---IQEILELSRgsatipyAEQEIT-- 441
Cdd:PRK10755 140 FTADVAHELRTP---LAGIRLHL--------ELLEK-QHHIDVAPliARLDQMmhtVEQLLQLAR-------AGQSFSsg 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 442 -------LEKFIT-------EILGSYQQQLAAKQLKT--VVHGLPEsqfftkyeLFYPIVKNLIENAIQYSQENGQITIS 505
Cdd:PRK10755 201 hyqtvklLEDVILpsqdelsEMLEQRQQTLLLPESAAdiTVQGDAT--------LLRLLLRNLVENAHRYSPEGSTITIK 272
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488312470 506 YAIENQQLRLSVQDTGIGISQKDQERIFERFYRVDkarSRHsGGTGLGLAIVQNYTELLGGKIAIDSH 573
Cdd:PRK10755 273 LSQEDGGAVLAVEDEGPGIDESKCGELSKAFVRMD---SRY-GGIGLGLSIVSRITQLHHGQFFLQNR 336
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
484-585 |
6.13e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 68.20 E-value: 6.13e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 484 IVKNLIENAIQ-YSQENGQITISYAIENQ----------QLRLSVQDTGIGISQKDQERIFERFYrvdkarSRHSGGTGL 552
Cdd:cd16918 4 VFLNLVRNAAQaLAGSGGEIILRTRTQRQvtlghprhrlALRVSVIDNGPGIPPDLQDTIFYPMV------SGRENGTGL 77
|
90 100 110
....*....|....*....|....*....|...
gi 488312470 553 GLAIVQNYTELLGGKIAIDSHLGlGTTFTITLP 585
Cdd:cd16918 78 GLAIAQNIVSQHGGVIECDSQPG-HTVFSVSLP 109
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
365-431 |
6.24e-14 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 66.82 E-value: 6.24e-14
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488312470 365 MQKDFVSNVSHELKTPVTSLLGFTETLIDGAKEDPEVlnQFLHIMQKDAQRLQQLIQEILELSRGSA 431
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQR--EYLETILREAERLLRLINDLLDLSRIEA 65
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
484-584 |
1.99e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 63.63 E-value: 1.99e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 484 IVKNLIENAIQ--YSQENGQITISYAIENQQLRLSVQDTGIGISQKDQERIFERFYrvdkaRSRHSG-GTGLGLAIVQNY 560
Cdd:cd16976 4 VLMNLLQNALDamGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFF-----TTKPVGkGTGLGLSISYGI 78
|
90 100
....*....|....*....|....
gi 488312470 561 TELLGGKIAIDSHLGLGTTFTITL 584
Cdd:cd16976 79 VEEHGGRLSVANEEGAGARFTFDL 102
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
408-589 |
2.50e-12 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 69.28 E-value: 2.50e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 408 IMQKDAQRLQQLIQEILELSRgsATIPYAEQEITLEKFItEILGSY---QQQLAAKQLKTVVHgLPESqfFTKYELFYPI 484
Cdd:COG2972 267 AELEDPEEAEEMLEALSKLLR--YSLSKGDELVTLEEEL-ELIKSYleiQKLRFGDRLEVEIE-IDEE--LLDLLIPKLI 340
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 485 VKNLIENAIQY----SQENGQITISYAIENQQLRLSVQDTGIGISQKDQERIFERFyrvdkarSRHSGGTGLGLAIVQNY 560
Cdd:COG2972 341 LQPLVENAIEHgiepKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL-------SSKGEGRGIGLRNVRER 413
|
170 180 190
....*....|....*....|....*....|..
gi 488312470 561 TELLGGK---IAIDSHLGLGTTFTITLPLTKK 589
Cdd:COG2972 414 LKLYYGEeygLEIESEPGEGTTVTIRIPLEEE 445
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
255-586 |
5.33e-11 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 64.33 E-value: 5.33e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 255 LLDELMIGVFIIDTQGRLRLLNPKMQEMLGLSAKNMQSNYL-EVIQDADL-IHLIHQVVAEKNSL-HQEITVTQGPTPLR 331
Cdd:PRK11073 12 ILNSLINSILLLDDDLAIHYANPAAQQLLAQSSRKLFGTPLpELLSYFSLnIELMRESLQAGQGFtDNEVTLVIDGRSHI 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 332 LDLSLRYLDDQsandYQVLGIA-YDLTRVRQLEKMQ-------KDFVSNVSHELKTPVTSLLGFTEtLIDGAKEDPEvLN 403
Cdd:PRK11073 92 LSLTAQRLPEG----MILLEMApMDNQRRLSQEQLQhaqqvaaRDLVRGLAHEIKNPLGGLRGAAQ-LLSKALPDPA-LT 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 404 QFLHIMQKDAQRLQQLIQEILELSRGSATIPYAEQEItLEKFITeiLGSYQQQLAAKQLKTVVHGLPEsqFFTKYELFYP 483
Cdd:PRK11073 166 EYTKVIIEQADRLRNLVDRLLGPQRPGTHVTESIHKV-AERVVQ--LVSLELPDNVRLIRDYDPSLPE--LAHDPDQIEQ 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 484 IVKNLIENAIQ-YSQENGQITI------SYAIENQQLRLS----VQDTGIGISQKDQERIFerfYRVDKARSrhsGGTGL 552
Cdd:PRK11073 241 VLLNIVRNALQaLGPEGGTITLrtrtafQLTLHGERYRLAaridIEDNGPGIPPHLQDTLF---YPMVSGRE---GGTGL 314
|
330 340 350
....*....|....*....|....*....|....
gi 488312470 553 GLAIVQNYTELLGGKIAIDSHLGlGTTFTITLPL 586
Cdd:PRK11073 315 GLSIARNLIDQHSGKIEFTSWPG-HTEFSVYLPI 347
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
488-591 |
1.81e-10 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 63.39 E-value: 1.81e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 488 LIENAIQY---SQENGQITISYAIENQQLRLSVQDTGIGISQkdqeriferfyRVDKARSRhsggtGLGLAIVQNYTELL 564
Cdd:COG3920 407 LVTNALKHaflSGEGGRIRVSWRREDGRLRLTVSDNGVGLPE-----------DVDPPARK-----GLGLRLIRALVRQL 470
|
90 100
....*....|....*....|....*..
gi 488312470 565 GGKIAIDShlGLGTTFTITLPLTKKEA 591
Cdd:COG3920 471 GGTLELDR--PEGTRVRITFPLAELAA 495
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
251-590 |
7.96e-10 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 61.39 E-value: 7.96e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 251 QFHELLDELMIGVFIIDTQGRLRLLNPKMQEMLGLSAKNMQ---SNYLEVIQDADLIHlihQVVAEK-----------NS 316
Cdd:PRK15053 223 QQEALFSSVYEGLIAVDPHGYITAINRNARKMLGLSSPGRQwlgKPIAEVVRPADFFT---EQIDEKrqdvvanfnglSV 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 317 LHQEITVTQGPTPLRLDLSLRYLDDQSANDYQvlgiaydLTRVRQLekmqKDFVSNVSHELKTPVTSLLGFTETlidgaK 396
Cdd:PRK15053 300 IANREAIRSGDDLLGAIISFRSKDEISTLNAQ-------LTQIKQY----VESLRTLRHEHLNWMSTLNGLLQM-----K 363
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 397 EdpevLNQFLHIMQKDAQRLQQLIQEILElsrgsatiPYAEQEITLEKFiteilGSYQQqlaAKQLK---TVV-----HG 468
Cdd:PRK15053 364 E----YDRVLEMVQGESQAQQQLIDSLRE--------AFADRQVAGLLF-----GKVQR---ARELGlkmVIVpgsqlSQ 423
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 469 LPESQFFTKyelFYPIVKNLIENAIQYS----QENGQITISYAIENQQLRLSVQDTGIGISQKDQERIFERFYrvdKARS 544
Cdd:PRK15053 424 LPPGLDSTE---FAAIVGNLLDNAFEASlrsdEGNKIVELFLSDEGDDVVIEVADQGCGVPESLRDKIFEQGV---STRA 497
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 488312470 545 RHSGGTGLGLAIVQNYTELLGGKIAIDSHLGLGTTFTITLPLTKKE 590
Cdd:PRK15053 498 DEPGEHGIGLYLIASYVTRCGGVITLEDNDPCGTLFSIFIPKVKPN 543
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
371-575 |
1.02e-09 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 61.19 E-value: 1.02e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 371 SNVSHELKTPVT-------SLLGFTETLIDGAkeDPevlnqflhIMQKDAQRLQQLIQEILE----------LSRGSATI 433
Cdd:PRK10815 271 TDLTHSLKTPLAvlqstlrSLRSGKQMSVEQA--EP--------IMLEQISRISQQIGYYLHrasmrsehnlLSRELHSV 340
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 434 PyaeqeITLEKFITEILGSYQQqlaakqlKTVVHGL---PESQFFTKYELFYPIVKNLIENAIQYSQENGQITISYAieN 510
Cdd:PRK10815 341 A-----PLLDNLTSALNKVYQR-------KGVNITLdisPEITFVGEKNDFMEVMGNVLDNACKYCLEFVEISARQT--D 406
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488312470 511 QQLRLSVQDTGIGISQKDQERIFERFYRVDKARSrhsgGTGLGLAIVQNYTELLGGKIAI-DSHLG 575
Cdd:PRK10815 407 EHLHIVVEDDGPGIPESKRELIFDRGQRADTLRP----GQGLGLSVAREITEQYEGKISAgDSPLG 468
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
360-587 |
1.18e-09 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 61.49 E-value: 1.18e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 360 RQLEKMQ---KDFVSNVSHELKTPVTSLLGFTETL--IDGAKEDPEVLNQFLhimqKDAQRLQQLIQEILELSRGSATIP 434
Cdd:PRK10618 441 REYEKNQqarKAFLQNIGDELKQPLQSLAQLAAQLrqTSDEEQQQPELDQLA----EQSDVLVRLVDNIQLLNMLETQDW 516
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 435 YAEQEI-TLEKFITEILGSYQQQLAAKQLKTVVHGL--PESQFFTKYELFYPIVKNLIENAI---QYsqenGQITISYAI 508
Cdd:PRK10618 517 KPEQELfSLQDLIDEVLPEVLPAIKRKGLQLLIHNHlkAEQLRIGDRDALRKILLLLLNYAItttAY----GKITLEVDQ 592
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 509 ENQ---QLRLSVQDTGIGISQKDQERIfeRFYRVDKARS-RHSGGTGLGLAIVQNYTELLGGKIAIDSHLGLGTTFTITL 584
Cdd:PRK10618 593 DESspdRLTIRILDTGAGVSIKELDNL--HFPFLNQTQGdRYGKASGLTFFLCNQLCRKLGGHLTIKSREGLGTRYSIHL 670
|
...
gi 488312470 585 PLT 587
Cdd:PRK10618 671 KML 673
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
402-589 |
4.85e-09 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 57.32 E-value: 4.85e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 402 LNQFLHIMQKDAQRLQQLIQEILELSRGSAT---------IPYAEQEITLEKFITEILGSYQQQlAAKQLKTVVHGLPES 472
Cdd:COG4585 76 LEAARRLLDADPEAAREELEEIRELAREALAelrrlvrglRPPALDDLGLAAALEELAERLLRA-AGIRVELDVDGDPDR 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 473 QFFTKYELFYPIVKNLIENAIQYSQENgQITISYAIENQQLRLSVQDTGIGISQKDQeriferfyrvdkarsrhsGGTGL 552
Cdd:COG4585 155 LPPEVELALYRIVQEALTNALKHAGAT-RVTVTLEVDDGELTLTVRDDGVGFDPEAA------------------PGGGL 215
|
170 180 190
....*....|....*....|....*....|....*..
gi 488312470 553 GLAIVQNYTELLGGKIAIDSHLGLGTTFTITLPLTKK 589
Cdd:COG4585 216 GLRGMRERAEALGGTLTIGSAPGGGTRVRATLPLAAA 252
|
|
| sCache_like |
pfam16736 |
Single Cache-like; This entry represents the N-terminal Cache-like domain of the alkaline ... |
36-155 |
1.20e-08 |
|
Single Cache-like; This entry represents the N-terminal Cache-like domain of the alkaline phosphatase synthesis sensor protein PhoR. It covers part of the PAS-like fold that share a central five-stranded beta- sheet of identical topology to other PAS domains.
Pssm-ID: 407005 Cd Length: 114 Bit Score: 53.16 E-value: 1.20e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 36 VAQQETYLRRKNTLLTDQLppsvfEKGQLTNQQQLLVTHALDDA-EERVTLLQKNGTVFFDSSQNEPLESHkkRPEIAAV 114
Cdd:pfam16736 2 VEKLEERMEKEAKLLASLL-----ENENLDAAQNKTVLEEASEKlDARITIIDADGKVLYDTGGETEDAEH--EAIIQEL 74
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 488312470 115 LSGATYGSaLRKSKTLNKELLYVATPVLKSGEIVGIIRISE 155
Cdd:pfam16736 75 LSGEELQE-VRVITTDEDDLLYYAVPIQKEGEQEGYILLSS 114
|
|
| CheA |
COG0643 |
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms]; |
498-587 |
1.39e-08 |
|
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 57.50 E-value: 1.39e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 498 ENGQITISYAIENQQLRLSVQDTGIGIsqkDQERIFErfyrvdKARSR---------------------HSG-------- 548
Cdd:COG0643 307 ETGTITLSAYHEGGRVVIEVSDDGRGL---DLEKIRA------KAIEKglitaeeaaalsdeellelifAPGfstaeevt 377
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 488312470 549 ---GTGLGLAIVQNYTELLGGKIAIDSHLGLGTTFTITLPLT 587
Cdd:COG0643 378 dlsGRGVGMDVVKTNIEALGGTIEIESEPGKGTTFTLRLPLT 419
|
|
| LytS |
COG3275 |
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms]; |
488-589 |
1.66e-08 |
|
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
Pssm-ID: 442506 [Multi-domain] Cd Length: 352 Bit Score: 56.80 E-value: 1.66e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 488 LIENAIQY----SQENGQITISYAIENQQLRLSVQDTGIGISQKdqeriferfyrvdkarsRHSGGTGLGLAIVQNYTEL 563
Cdd:COG3275 261 LVENAIKHgissKEGGGTISISIEVEGDRLVIEVENNGVGIQPK-----------------KKKKGSGIGLKNVRERLEL 323
|
90 100
....*....|....*....|....*....
gi 488312470 564 LGGK---IAIDSHLGLGTTFTITLPLTKK 589
Cdd:COG3275 324 LYGDkysLEIESTDGGGTKVTLKIPLKKE 352
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
498-585 |
7.23e-08 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 52.58 E-value: 7.23e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 498 ENGQITISYAIENQQLRLSVQDTGIGIsqkDQERIFErfyrvdKARSR---------------------HSG-------- 548
Cdd:cd16916 68 PEGTITLRAEHQGNQVVIEVSDDGRGI---DREKIRE------KAIERglitadeaatlsddevlnlifAPGfstaeqvt 138
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 488312470 549 ---GTGLGLAIVQNYTELLGGKIAIDSHLGLGTTFTITLP 585
Cdd:cd16916 139 dvsGRGVGMDVVKRSIESLGGTIEVESEPGQGTTFTIRLP 178
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
482-585 |
4.61e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 47.93 E-value: 4.61e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 482 YPIVKNLIENAIQYSQEnGQITISYAIENQQLRLSVQDTGIGIsqkdqeriferfyrvdkARSRHSGGTGLGLAIVQNYT 561
Cdd:cd16917 2 YRIVQEALTNALKHAGA-SRVRVTLSYTADELTLTVVDDGVGF-----------------DGPAPPGGGGFGLLGMRERA 63
|
90 100
....*....|....*....|....
gi 488312470 562 ELLGGKIAIDSHLGLGTTFTITLP 585
Cdd:cd16917 64 ELLGGTLTIGSRPGGGTRVTARLP 87
|
|
| PAS_4 |
pfam08448 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
256-361 |
5.69e-07 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain is associated to signalling systems and works as a signal sensor domain. It recognizes differently substituted aromatic hydrocarbons, oxygen, different dodecanoic acids, autoinducers, 3,5-dimethyl-pyrazin-2-ol and N-alanyl-aminoacetone (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 312075 [Multi-domain] Cd Length: 110 Bit Score: 48.18 E-value: 5.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 256 LDELMIGVFIIDTQGRLRLLNPKMQEMLGLSAKNM-----QSNYLEVIQdADLIHLIHQVVAEKNSLHQEITVTQGPTPL 330
Cdd:pfam08448 1 LDSLPDALAVLDPDGRVRYANAAAAELFGLPPEELlgktlAELLPPEDA-ARLERALRRALEGEEPIDFLEELLLNGEER 79
|
90 100 110
....*....|....*....|....*....|.
gi 488312470 331 RLDLSLRYLDDQSANDYQVLGIAYDLTRVRQ 361
Cdd:pfam08448 80 HYELRLTPLRDPDGEVIGVLVISRDITERRR 110
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
515-591 |
7.16e-06 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 48.90 E-value: 7.16e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488312470 515 LSVQDTGIGISQKDQERIFERFYRvdkarSRHSG-GTGLGLAIVQNYTELLGGKIAIDSHLGLGTTFTITLPLTKKEA 591
Cdd:PRK13557 327 IAVTDTGSGMPPEILARVMDPFFT-----TKEEGkGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFPASDQAE 399
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
250-364 |
1.03e-05 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 47.33 E-value: 1.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 250 EQFHELLDELMIGVFIIDTQGRLRLLNPKMQEMLGLSAKNMQSNYLEVI----QDADLIHLIHQVVAEKNSLHQEITVTQ 325
Cdd:COG2202 137 ERLRLLVENAPDGIFVLDLDGRILYVNPAAEELLGYSPEELLGKSLLDLlhpeDRERLLELLRRLLEGGRESYELELRLK 216
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 488312470 326 GPTPLRLDLSLRYLDDQSANDYQ-VLGIAYDLTRVRQLEK 364
Cdd:COG2202 217 DGDGRWVWVEASAVPLRDGGEVIgVLGIVRDITERKRAEE 256
|
|
| ArsS_fam_HK |
NF038389 |
ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase ... |
355-559 |
1.12e-05 |
|
ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase participating in a two-component system that controls the response to acid conditiions encountered during the process of gastric colonization. This HMM identified ArsS itself but also a broader collection of apparent orthologs from closely related non-gastric colonizers such as Helicobacter hepaticus, Campylobacter jejuni and Wolinella succinogenes. See BlastRule NBR014349 for specific identification of ArsS itself, distinguished by a signature His residue that becomes protonated at low pH.
Pssm-ID: 468500 [Multi-domain] Cd Length: 402 Bit Score: 47.92 E-value: 1.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 355 DLTRVRQLekmqkdFVSNVSHELKTPVTSLLGFTETLidgakEDPEVLNQFLHIMqkdaQRLQQLIQE---ILELSRGSA 431
Cdd:NF038389 201 ALNESRQL------FLRNIMHELKTPITKGRIVAEML-----EDEKQKERLISIF----ERLESLINEfakIEQLTSKNY 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 432 TIPYaeQEITLEKFI---TEILgsyqqqLAAKQLKTVVHGLPESQFFTKYELFYPIVKNLIENAIQYSqENGQITIsYAI 508
Cdd:NF038389 266 KLNK--KEYRLSDIIdeaIDML------MIDDSSVIIKVSLEDFKLNVDFELFSLAIKNLIDNAIKYS-PDKKVTI-EIK 335
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 488312470 509 ENqqlRLSVQDTGIGIsQKDQERIFERFYrvdKARSRHSGGTGLGLAIVQN 559
Cdd:NF038389 336 GD---KIEFKNKGEPL-EEPLEYYFEPFF---KGNEKSKSGFGLGLYIVKN 379
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
484-585 |
1.16e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 44.45 E-value: 1.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 484 IVKNLIENAIQYSQENGQITI-SYAIENQQLRLSVQDTGIGISQKDQERIFERfYRVDKARsrhsgGTGLGLAIVQNYTE 562
Cdd:cd16944 12 ILKNAAEAIEGRPSDVGEVRIrVEADQDGRIVLIVCDNGKGFPREMRHRATEP-YVTTRPK-----GTGLGLAIVKKIME 85
|
90 100
....*....|....*....|...
gi 488312470 563 LLGGKIAIDSHLGLGTTFTITLP 585
Cdd:cd16944 86 EHGGRISLSNREAGGACIRIILP 108
|
|
| HATPase_EL346-LOV-HK-like |
cd16951 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
484-585 |
1.44e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.
Pssm-ID: 340427 [Multi-domain] Cd Length: 131 Bit Score: 44.72 E-value: 1.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 484 IVKNLIENAIQYS---QENGQITISYAIENQQLRLSVQDTGIGISQKDqeriferfyrvDKARSrhsggTGLGLAIVQNY 560
Cdd:cd16951 43 VVNELLQNALKHAfsdREGGTITIRSVVDGDYLRITVIDDGVGLPQDE-----------DWPNK-----GSLGLQIVRSL 106
|
90 100
....*....|....*....|....*.
gi 488312470 561 TE-LLGGKIAIDSHlGLGTTFTITLP 585
Cdd:cd16951 107 VEgELKAFLEVQSA-ENGTRVNIDIP 131
|
|
| HATPase_YpdA-YehU-LytS-like |
cd16924 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
483-585 |
1.51e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340401 [Multi-domain] Cd Length: 103 Bit Score: 43.97 E-value: 1.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 483 PIVKNLIENAIQYSQENGQITISYAIENQQLRLSVQDTGIGISQKDQERIferfyrvdkaRSRHSGGTGLGLAIV-QNYT 561
Cdd:cd16924 8 PLVENAIQHGLSPLTDKGVVTISALKEDNHVMIEVEDNGRGIDPKVLNIL----------GKKPKEGNGIGLYNVhQRLI 77
|
90 100
....*....|....*....|....*.
gi 488312470 562 ELLGGK--IAIDSHLGLGTTFTITLP 585
Cdd:cd16924 78 LLFGEDygIHIASEPDKGTRITFTIP 103
|
|
| PAS |
smart00091 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
250-310 |
2.54e-05 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.
Pssm-ID: 214512 Cd Length: 67 Bit Score: 42.39 E-value: 2.54e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488312470 250 EQFHELLDELMIGVFIIDTQGRLRLLNPKMQEMLGLSAKN-MQSNYLEVIQDADLIHLIHQV 310
Cdd:smart00091 1 ERLRAILESLPDGIFVLDLDGRILYANPAAEELLGYSPEElIGKSLLELIHPEDRERVQEAL 62
|
|
| PRK11644 |
PRK11644 |
signal transduction histidine-protein kinase/phosphatase UhpB; |
491-586 |
3.09e-05 |
|
signal transduction histidine-protein kinase/phosphatase UhpB;
Pssm-ID: 236945 [Multi-domain] Cd Length: 495 Bit Score: 46.89 E-value: 3.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 491 NAIQYSQENgQITISYAIENQQLRLSVQDTGIGISQkdqeriferfyrvdkarsrHSGGTGLGLAIVQNYTELLGGKIAI 570
Cdd:PRK11644 421 NIVKHADAS-AVTLQGWQQDERLMLVIEDDGSGLPP-------------------GSGQQGFGLRGMRERVTALGGTLTI 480
|
90
....*....|....*.
gi 488312470 571 DSHlgLGTTFTITLPL 586
Cdd:PRK11644 481 SCT--HGTRLSVSLPQ 494
|
|
| HATPase_YpdA-like |
cd16955 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
483-585 |
6.29e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340431 [Multi-domain] Cd Length: 102 Bit Score: 42.45 E-value: 6.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 483 PIVKNLIENAIQYSQENGQITISYAIENQ-QLRLSVQDTGIGISQKDQERIferfyrvdkaRSRHSGGTGLGLAIVQNYT 561
Cdd:cd16955 8 PLVENAIVHGIQEKKGKGVVKISVKKQLKnRLHIAVEDNGIGISPKVIERV----------EQDEMPGNKIGLLNVHQRL 77
|
90 100
....*....|....*....|....*
gi 488312470 562 ELL-GGKIAIDSHLGLGTTFTITLP 585
Cdd:cd16955 78 KLGyGEGLHIRSRPDPGTLIAFYIP 102
|
|
| PAS_8 |
pfam13188 |
PAS domain; PAS domains are involved in many signalling proteins where they are used as a ... |
250-291 |
7.00e-05 |
|
PAS domain; PAS domains are involved in many signalling proteins where they are used as a signal sensor domain. PAS domains appear in archaea, bacteria and eukaryotes. Several PAS-domain proteins are known to detect their signal by way of an associated cofactor. Heme, flavin, and a 4-hydroxycinnamyl chromophore are used in different proteins. This domain recognizes oxygen and CO (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 463802 [Multi-domain] Cd Length: 65 Bit Score: 41.00 E-value: 7.00e-05
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 488312470 250 EQFHELLDELMIGVFIIDTQGRLRLLNPKMQEMLGLSAKNMQ 291
Cdd:pfam13188 1 ERLRALFESSPDGILVLDEGGRIIYVNPAALELLGYELLGEL 42
|
|
| HATPase_LytS-like |
cd16957 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
488-585 |
8.07e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.
Pssm-ID: 340433 [Multi-domain] Cd Length: 106 Bit Score: 42.03 E-value: 8.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 488 LIENAIQYS----QENGQITISYAIENQQLRLSVQDTGIGISQkdqerifERFYRVDKARSRHSGGTGLGLAIVQNYTEL 563
Cdd:cd16957 9 LVENAIRHAfpkrKENNEVRVVVKKDQHKVHVSVSDNGQGIPE-------ERLDLLGKTTVTSEKGTGTALENLNRRLIG 81
|
90 100
....*....|....*....|....*
gi 488312470 564 LGGKIA---IDSHLGLGTTFTITLP 585
Cdd:cd16957 82 LFGSEAclhIESEVHGGTEVWFVIP 106
|
|
| PAS |
pfam00989 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
250-355 |
8.31e-05 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 42.02 E-value: 8.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 250 EQFHELLDELMIGVFIIDTQGRLRLLNPKMQEMLGLSAKNMQS-NYLEVI---QDADLIHLIHQVVAEKN-SLHQEIT-- 322
Cdd:pfam00989 1 EDLRAILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGkSLLDLIpeeDDAEVAELLRQALLQGEeSRGFEVSfr 80
|
90 100 110
....*....|....*....|....*....|...
gi 488312470 323 VTQGpTPLRLDLSLRYLDDQSANDYQVLGIAYD 355
Cdd:pfam00989 81 VPDG-RPRHVEVRASPVRDAGGEILGFLGVLRD 112
|
|
| HATPase_PDK-like |
cd16929 |
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ... |
502-585 |
1.49e-04 |
|
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.
Pssm-ID: 340406 [Multi-domain] Cd Length: 169 Bit Score: 42.71 E-value: 1.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 502 ITISYAIENQQLRLSvqDTGIGISQKDQERIFERFY----------RVDKARSRHSG---GTGLGLAIVQNYTELLGGKI 568
Cdd:cd16929 75 VTVAKGDEDLTIKIS--DRGGGIPREDLARLFSYMYstapqpslddFSDLISGTQPSplaGFGYGLPMSRLYAEYFGGDL 152
|
90
....*....|....*..
gi 488312470 569 AIDSHLGLGTTFTITLP 585
Cdd:cd16929 153 DLQSMEGYGTDVYIYLK 169
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
243-364 |
2.65e-04 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 43.09 E-value: 2.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 243 KAYTSADEQFHELLDELMIGVFIIDTQGRLRLLNPKMQEMLGLSAKNMQSNYLEVIQ----DADLIHLIHQVVAEKNSLH 318
Cdd:COG2202 4 EALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTLRDLLppedDDEFLELLRAALAGGGVWR 83
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 488312470 319 QEIT-VTQGPTPLRLDLSLRYLDDQSANDYQVLGIAYDLTRVRQLEK 364
Cdd:COG2202 84 GELRnRRKDGSLFWVELSISPVRDEDGEITGFVGIARDITERKRAEE 130
|
|
| RocR |
COG3829 |
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ... |
250-364 |
3.44e-04 |
|
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];
Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 43.22 E-value: 3.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 250 EQFHELLDELMIGVFIIDTQGRLRLLNPKMQEMLGLSAKNMQSNYLEviqdaDLIH--LIHQVVAEKNSLHQEITVTQGP 327
Cdd:COG3829 11 EELEAILDSLDDGIIVVDADGRITYVNRAAERILGLPREEVIGKNVT-----ELIPnsPLLEVLKTGKPVTGVIQKTGGK 85
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 488312470 328 --------TPLRLDLSLRYlddqsandyqVLGIAYDLTRVRQLEK 364
Cdd:COG3829 86 gktvivtaIPIFEDGEVIG----------AVETFRDITELKRLER 120
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
456-574 |
3.98e-04 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 43.52 E-value: 3.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 456 QLAAKQLKTVVHGLPESQFFTKYELFYPIVKNLIENAIQYSQENGQITISYAIENQQLRLSVQDTGIGISqkDQERIFER 535
Cdd:COG4192 519 ESRAKPQQITLHIPDDLMVQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSNAENLRVAISDNGNGWP--LVDKLFTP 596
|
90 100 110
....*....|....*....|....*....|....*....
gi 488312470 536 FYrvdkarSRHSGGTGLGLAIVQNYTELLGGKIAIDSHL 574
Cdd:COG4192 597 FT------TTKEVGLGLGLSICRSIMQQFGGDLYLASTL 629
|
|
| PRK11388 |
PRK11388 |
DNA-binding transcriptional regulator DhaR; Provisional |
251-384 |
9.21e-04 |
|
DNA-binding transcriptional regulator DhaR; Provisional
Pssm-ID: 183114 [Multi-domain] Cd Length: 638 Bit Score: 42.36 E-value: 9.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 251 QFHELLDELMIGVFIIDTQGRLRLLNPKMQEMLGLSAKNMQSNylEVIQDADLIHLIHQVVAEKNSL-HQEITVTQGPTP 329
Cdd:PRK11388 204 QLNALLESMDDGVIAWDEQGNLQFLNAQAARLLRLDATASQGR--AITELLTLPAVLQQAIKQAHPLkHVEVTFESQGQF 281
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 488312470 330 LRLDLSLRYLDDQSANDYQVLgiAYDLTRVRQLEKMQkdfVSNVSHELKT-PVTSL 384
Cdd:PRK11388 282 IDAVITLKPIIEGQGTSFILL--LHPVEQMRQLMTSQ---LGKVSHTFDHmPQDSP 332
|
|
| PAS |
cd00130 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
262-356 |
1.79e-03 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.
Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 38.00 E-value: 1.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 262 GVFIIDTQGRLRLLNPKMQEMLGLSAKNMQ-SNYLEVIQDADLIHLIHQVVAEKNSLHQEIT----VTQGPTPLRLDLSL 336
Cdd:cd00130 4 GVIVLDLDGRILYANPAAEQLLGYSPEELIgKSLLDLIHPEDREELRERLENLLSGGEPVTLevrlRRKDGSVIWVLVSL 83
|
90 100
....*....|....*....|
gi 488312470 337 RYLDDQSANDYQVLGIAYDL 356
Cdd:cd00130 84 TPIRDEGGEVIGLLGVVRDI 103
|
|
| HATPase_YehU-like |
cd16956 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
483-585 |
1.93e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.
Pssm-ID: 340432 [Multi-domain] Cd Length: 101 Bit Score: 38.19 E-value: 1.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 483 PIVKNLIENAIQYSQENGQITISYAIENQQLRLSVQDTGIGISQKDQERIFerfyrvdkarSRHSGGTGLGLaIVQNYTE 562
Cdd:cd16956 8 PIVENAVKHGLSGLLDGGRVEITARLDGQHLLLEVEDNGGGMDPDTLARIL----------IRSSNGLGLNL-VDKRLRQ 76
|
90 100
....*....|....*....|....*
gi 488312470 563 LLGGK--IAIDSHLGLGTTFTITLP 585
Cdd:cd16956 77 AFGNDygLDIECAPGEGTRITIRLP 101
|
|
| HATPase_SpoIIAB-like |
cd16942 |
Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein ... |
484-583 |
3.20e-03 |
|
Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of SpoIIAB, an anti sigma-F factor and a serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli where, early in sporulation, the cell divides into two unequal compartments: a larger mother cell and a smaller forespore. Sigma-F transcription factor is activated in the forespore directly after the asymmetric septum forms, and its spatial and temporal activation is required for sporulation. Free sigma-F can associate with the RNA polymerase core and activate transcription of the sigma-F regulon, its regulation may comprise a partner-switching mechanism involving SpoIIAB, SpoIIAA, and sigma-F as follows: SpoIIAB can form alternative complexes with either: i) sigma-F, holding it in an inactive form and preventing its association with RNA polymerase, or ii) unphosphorylated SpoIIAA and a nucleotide, either ATP or ADP. In the presence of ATP, SpoIIAB acts as a kinase to specifically phosphorylate a serine residue of SpoIIAA; this phosphorylated form has low affinity for SpoIIAB and dissociates, making SpoIIAB available to capture sigma-F. SpoIIAA may then be dephosphorylated by a SpoIIE serine phosphatase and be free to attack the SpoIIAB sigma-F complex to induce the release of sigma-F.
Pssm-ID: 340418 [Multi-domain] Cd Length: 135 Bit Score: 38.29 E-value: 3.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 484 IVKNLIENAIQYS---QENGQITISYAIENQQLRLSVQDTGIGISQKDQERifERFYRVDKARSRhsggTGLGLAIVQNY 560
Cdd:cd16942 42 VVSEAVTNAIIHGynnDPNGIVSISVIIEDGVVHLTVRDEGVGIPDIEEAR--QPLFTTKPELER----SGMGFTIMENF 115
|
90 100
....*....|....*....|...
gi 488312470 561 TEllggKIAIDSHLGLGTTFTIT 583
Cdd:cd16942 116 MD----EVIVESEVNKGTTVYLK 134
|
|
| HATPase_TopVIB-like |
cd16933 |
Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family ... |
482-567 |
4.15e-03 |
|
Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family includes the histidine kinase-like ATPase (HATPase) domain of the B subunit of topoisomerase VI (Topo VIB). Topo VI is a heterotetrameric complex composed of two TopVIA and two TopVIB subunits and is categorized as a type II B DNA topoisomerase. It is found in archaea and also in plants. Type II enzymes cleave both strands of a DNA duplex and pass a second duplex through the resulting break in an ATP-dependent mechanism. DNA cleavage by Topo VI generates two-nucleotide 5'-protruding ends.
Pssm-ID: 340410 [Multi-domain] Cd Length: 203 Bit Score: 38.87 E-value: 4.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 482 YPIVKNLIENAIQYSQENG-----QITISyAIENQQLRLSVQDTGIGISQKDQERIFERFYRVDKARSRHSGGT-GLGLA 555
Cdd:cd16933 21 YTTVRELVENSLDATEEAGilpdiKVEIE-EIGKDHYKVIVEDNGPGIPEEQIPKVFGKVLYGSKYHNKQSRGQqGLGIS 99
|
90
....*....|..
gi 488312470 556 IVQNYTELLGGK 567
Cdd:cd16933 100 AAVLYSQMTTGK 111
|
|
| PRK10600 |
PRK10600 |
nitrate/nitrite two-component system sensor histidine kinase NarX; |
484-583 |
7.79e-03 |
|
nitrate/nitrite two-component system sensor histidine kinase NarX;
Pssm-ID: 182581 [Multi-domain] Cd Length: 569 Bit Score: 39.27 E-value: 7.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488312470 484 IVKNLIENAIQYSQENgQITISYAIENQQLRLSVQDTGIGISQkdqeriferfyrvDKARSRHsggtgLGLAIVQNYTEL 563
Cdd:PRK10600 473 IAREALSNALKHAQAS-EVVVTVAQNQNQVKLSVQDNGCGVPE-------------NAERSNH-----YGLIIMRDRAQS 533
|
90 100
....*....|....*....|
gi 488312470 564 LGGKIAIDSHLGLGTTFTIT 583
Cdd:PRK10600 534 LRGDCRVRRRESGGTEVVVT 553
|
|
| |
