|
Name |
Accession |
Description |
Interval |
E-value |
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
218-421 |
2.88e-24 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 100.75 E-value: 2.88e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 218 LEFKNKEILKLEKLKYDFFKGASHELKTPLASLKIILENMKYNIGKYKERDI-YINECIEIVDSLTKNISQILSVHSIEN 296
Cdd:COG2205 2 LEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERReLLEIIRESAERLLRLIEDLLDLSRLES 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 297 --LNNDEEYLKINDTLEDILKKYEILANQKKITVNNYILDEN--VYIGKTALKIILSNLISNAVKYTDVNGVINIGI--V 370
Cdd:COG2205 82 gkLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELplVYADPELLEQVLANLLDNAIKYSPPGGTITISArrE 161
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 371 NDWLYIE---NSYGnnkIS--NMDKIFDvKF----DLNKENSNGLGLYIVSNILNNYNIE 421
Cdd:COG2205 162 GDGVRISvsdNGPG---IPeeELERIFE-RFyrgdNSRGEGGTGLGLAIVKRIVEAHGGT 217
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
11-419 |
7.95e-12 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 67.12 E-value: 7.95e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 11 FIQIFSVLGIIIILVHSLIFFIFPKTYLETRKEKIHNMANEISSNMNGKEIKYIEQTLEFYSKSSEIKVFIKEKNNKNEI 90
Cdd:COG4251 68 LLLLLLVLAALALLLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLAL 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 91 QIKDNINVNLESDSNSLIIEEREIKLNDGKKTNLQFVSTADMQKDAKDLSLKFLPYSLLISILFSAIISLIYAKSIKNNI 170
Cdd:COG4251 148 ALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGL 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 171 QEIKIVTDKMMKLDKKMSLKVSSNDEVGELKQQINDLYSTLLRTIDDLEFKNKEilkLEklkyDFFKGASHELKTPLAS- 249
Cdd:COG4251 228 LLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAELERSNEE---LE----QFAYVASHDLREPLRKi 300
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 250 ---LKIILEnmkynigKYKER-DIYINECIEIVDSLTKN----ISQILSVHSIENLNNDEEYLKINDTLEDILKKYEILA 321
Cdd:COG4251 301 sgfSQLLEE-------DYGDKlDEEGREYLERIRDAAERmqalIDDLLAYSRVGRQELEFEPVDLNELLEEVLEDLEPRI 373
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 322 NQKKITVNnyiLDE--NVYIGKTALKIILSNLISNAVKYT--DVNGVINIGIV---NDWLY--------IENSYGnnkis 386
Cdd:COG4251 374 EERGAEIE---VGPlpTVRGDPTLLRQVFQNLISNAIKYSrpGEPPRIEIGAEregGEWVFsvrdngigIDPEYA----- 445
|
410 420 430
....*....|....*....|....*....|....*..
gi 488229286 387 nmDKIFDVkFD-LNKEN---SNGLGLYIVSNILNNYN 419
Cdd:COG4251 446 --EKIFEI-FQrLHSRDeyeGTGIGLAIVKKIVERHG 479
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
147-419 |
1.14e-09 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 60.03 E-value: 1.14e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 147 SLLI---SILFSAIISLIYAKSIknnIQEIKIVTDKMMKL---DKKMSLKVSSNDEVGELKQQINDLYSTLlrtiddlEf 220
Cdd:PRK10549 166 SWLIvalSTLLAALATFLLARGL---LAPVKRLVEGTHKLaagDFTTRVTPTSRDELGRLAQDFNQLASTL-------E- 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 221 KNkeilklEKLKYDFFKGASHELKTPLASLKIILENMKYNIGKYKERDiyINECIEIVDSLTKNISQI--LSVHSIENLN 298
Cdd:PRK10549 235 KN------EQMRRDFMADISHELRTPLAVLRGELEAIQDGVRKFTPES--VASLQAEVGTLTKLVDDLhqLSLSDEGALA 306
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 299 NDEEYLKINDTLEDILKKYEILANQKKITVNNYILDENVYIG-KTALKIILSNLISNAVKYTDVNGVINIGIVND----W 373
Cdd:PRK10549 307 YRKTPVDLVPLLEVAGGAFRERFASRGLTLQLSLPDSATVFGdPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRdktlR 386
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 488229286 374 LYIENSYGNNKISNMDKIFDvKFdLNKENS-------NGLGLYIVSNILNNYN 419
Cdd:PRK10549 387 LTFADSAPGVSDEQLQKLFE-RF-YRTEGSrnrasggSGLGLAICLNIVEAHN 437
|
|
| ArsS_fam_HK |
NF038389 |
ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase ... |
11-434 |
8.28e-08 |
|
ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase participating in a two-component system that controls the response to acid conditiions encountered during the process of gastric colonization. This HMM identified ArsS itself but also a broader collection of apparent orthologs from closely related non-gastric colonizers such as Helicobacter hepaticus, Campylobacter jejuni and Wolinella succinogenes. See BlastRule NBR014349 for specific identification of ArsS itself, distinguished by a signature His residue that becomes protonated at low pH.
Pssm-ID: 468500 [Multi-domain] Cd Length: 402 Bit Score: 54.08 E-value: 8.28e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 11 FIQIFSVLGIIIILVhSLIFFIFPKTYLETRKEKIHNMANEISSNMNGKEIKYI-EQTLEFYSKSSEIKVFIKEKNNKNE 89
Cdd:NF038389 4 FFKITILFAIALVSV-SALFLILLKYQKENYNEELNKKYSLIANTLLQLYQKNInEEELEKYLKNFGFMPITDKKLEKEI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 90 IQIKDNINVNLESDSNSLIIEEREIKLndgkktnlqFVSTADMQKDAKDLSLKFLPYSLLI--SILFSAIISLIYAkSIK 167
Cdd:NF038389 83 LEIGKNKFILKENGSFRILKYNDKIYL---------LIKNDGFSLLLEDNEKKSYRYYYIIvfFIFLILLLLILYI-SVL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 168 NNIQEIKIVTDKMMKL---DKKMSLKVSSNDEVGELKQQINDLYStllrtiddlefKNKEILKLEKLkydFFKGASHELK 244
Cdd:NF038389 153 KSLKPLKKLKKQIKKFangDFDFIKSESNGDEIGEVANEFDKAVK-----------KIKALNESRQL---FLRNIMHELK 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 245 TPLASLKIILENMKYNigKYKERDIYINECIEI-VDSLTKnISQILSVHSienLNNDEEYlkindTLEDILKKYEILA-- 321
Cdd:NF038389 219 TPITKGRIVAEMLEDE--KQKERLISIFERLESlINEFAK-IEQLTSKNY---KLNKKEY-----RLSDIIDEAIDMLmi 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 322 ----NQKKITVNNYILDENVYIGKTALKiilsNLISNAVKYTDvNGVINIGIVNDWLYIENSyGN---NKISNMDKIFdV 394
Cdd:NF038389 288 ddssVIIKVSLEDFKLNVDFELFSLAIK----NLIDNAIKYSP-DKKVTIEIKGDKIEFKNK-GEpleEPLEYYFEPF-F 360
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 488229286 395 KFDLNKENSNGLGLYIVSNIL--NNYNIEYKVLQDEEFFIFK 434
Cdd:NF038389 361 KGNEKSKSGFGLGLYIVKNILkaHGFKLEYEYENGYNIFIIK 402
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
229-291 |
1.53e-07 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 47.98 E-value: 1.53e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488229286 229 EKLKYDFFKGASHELKTPLASLKIILENMKYNIGKYKERDIYINECIEIVDSLTKNISQILSV 291
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDL 63
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
343-437 |
5.79e-07 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 48.03 E-value: 5.79e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 343 ALKIILSNLISNAVKYTDVNGVINIGI--VNDWLYIENSygNN----KISNMDKIFD----VKFDLNKENSNGLGLYIVS 412
Cdd:smart00387 5 RLRQVLSNLLDNAIKYTPEGGRITVTLerDGDHVEITVE--DNgpgiPPEDLEKIFEpffrTDKRSRKIGGTGLGLSIVK 82
|
90 100
....*....|....*....|....*...
gi 488229286 413 NILNNYNIEYKVLQDEE---FFIFKIKI 437
Cdd:smart00387 83 KLVELHGGEISVESEPGggtTFTITLPL 110
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
342-436 |
5.78e-05 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 41.97 E-value: 5.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 342 TALKIILSNLISNAVKYTDVNGVINIGI-VNDWLYIEnsygnnkISN---------MDKIFDvKF---DLNKENSNGLGL 408
Cdd:pfam02518 4 LRLRQVLSNLLDNALKHAAKAGEITVTLsEGGELTLT-------VEDngigippedLPRIFE-PFstaDKRGGGGTGLGL 75
|
90 100 110
....*....|....*....|....*....|.
gi 488229286 409 YIVSNILNNYNIEYKVLQDEE---FFIFKIK 436
Cdd:pfam02518 76 SIVRKLVELLGGTITVESEPGggtTVTLTLP 106
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
218-421 |
2.88e-24 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 100.75 E-value: 2.88e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 218 LEFKNKEILKLEKLKYDFFKGASHELKTPLASLKIILENMKYNIGKYKERDI-YINECIEIVDSLTKNISQILSVHSIEN 296
Cdd:COG2205 2 LEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERReLLEIIRESAERLLRLIEDLLDLSRLES 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 297 --LNNDEEYLKINDTLEDILKKYEILANQKKITVNNYILDEN--VYIGKTALKIILSNLISNAVKYTDVNGVINIGI--V 370
Cdd:COG2205 82 gkLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELplVYADPELLEQVLANLLDNAIKYSPPGGTITISArrE 161
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 371 NDWLYIE---NSYGnnkIS--NMDKIFDvKF----DLNKENSNGLGLYIVSNILNNYNIE 421
Cdd:COG2205 162 GDGVRISvsdNGPG---IPeeELERIFE-RFyrgdNSRGEGGTGLGLAIVKRIVEAHGGT 217
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
195-421 |
9.03e-24 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 101.14 E-value: 9.03e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 195 DEVGELKQQINDLYSTLLRTIDDLEFKNKEILKLEKLKYDFFKGASHELKTPLASLKIILENMKYNIGKykERDIYINEC 274
Cdd:COG0642 73 LLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDE--EQREYLETI 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 275 IEIVDSLTKNISQILSVHSIENLNNDEEY--LKINDTLEDILKKYEILANQKKITVNNYILDE--NVYIGKTALKIILSN 350
Cdd:COG0642 151 LRSADRLLRLINDLLDLSRLEAGKLELEPepVDLAELLEEVVELFRPLAEEKGIELELDLPDDlpTVRGDPDRLRQVLLN 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 351 LISNAVKYTDVNGVINIGI--VNDWLYIEnsygnnkISN---------MDKIFDvKF----DLNKENSNGLGLYIVSNIL 415
Cdd:COG0642 231 LLSNAIKYTPEGGTVTVSVrrEGDRVRIS-------VEDtgpgippedLERIFE-PFfrtdPSRRGGGTGLGLAIVKRIV 302
|
....*.
gi 488229286 416 NNYNIE 421
Cdd:COG0642 303 ELHGGT 308
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
224-424 |
1.20e-23 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 101.94 E-value: 1.20e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 224 EILKLEKLKYDFFKGASHELKTPLASLKIILENMKYNIGKYKE-RDIYINECIEIVDSLTKNISQILSVHSIEN--LNND 300
Cdd:COG5002 157 ELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAADDPEeRREYLEIILEEAERLSRLVNDLLDLSRLESgeLKLE 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 301 EEYLKINDTLEDILKKYEILANQKKITVNNYILDEN--VYIGKTALKIILSNLISNAVKYTDVNGVINIGI--VNDWLYI 376
Cdd:COG5002 237 KEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDPllVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLreEDDQVRI 316
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488229286 377 EnsygnnkISN---------MDKIFD----VKFDLNKENS-NGLGLYIVSNILNNYNIEYKV 424
Cdd:COG5002 317 S-------VRDtgigipeedLPRIFErfyrVDKSRSRETGgTGLGLAIVKHIVEAHGGRIWV 371
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
11-419 |
7.95e-12 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 67.12 E-value: 7.95e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 11 FIQIFSVLGIIIILVHSLIFFIFPKTYLETRKEKIHNMANEISSNMNGKEIKYIEQTLEFYSKSSEIKVFIKEKNNKNEI 90
Cdd:COG4251 68 LLLLLLVLAALALLLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLAL 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 91 QIKDNINVNLESDSNSLIIEEREIKLNDGKKTNLQFVSTADMQKDAKDLSLKFLPYSLLISILFSAIISLIYAKSIKNNI 170
Cdd:COG4251 148 ALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGL 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 171 QEIKIVTDKMMKLDKKMSLKVSSNDEVGELKQQINDLYSTLLRTIDDLEFKNKEilkLEklkyDFFKGASHELKTPLAS- 249
Cdd:COG4251 228 LLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAELERSNEE---LE----QFAYVASHDLREPLRKi 300
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 250 ---LKIILEnmkynigKYKER-DIYINECIEIVDSLTKN----ISQILSVHSIENLNNDEEYLKINDTLEDILKKYEILA 321
Cdd:COG4251 301 sgfSQLLEE-------DYGDKlDEEGREYLERIRDAAERmqalIDDLLAYSRVGRQELEFEPVDLNELLEEVLEDLEPRI 373
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 322 NQKKITVNnyiLDE--NVYIGKTALKIILSNLISNAVKYT--DVNGVINIGIV---NDWLY--------IENSYGnnkis 386
Cdd:COG4251 374 EERGAEIE---VGPlpTVRGDPTLLRQVFQNLISNAIKYSrpGEPPRIEIGAEregGEWVFsvrdngigIDPEYA----- 445
|
410 420 430
....*....|....*....|....*....|....*..
gi 488229286 387 nmDKIFDVkFD-LNKEN---SNGLGLYIVSNILNNYN 419
Cdd:COG4251 446 --EKIFEI-FQrLHSRDeyeGTGIGLAIVKKIVERHG 479
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
147-419 |
1.14e-09 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 60.03 E-value: 1.14e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 147 SLLI---SILFSAIISLIYAKSIknnIQEIKIVTDKMMKL---DKKMSLKVSSNDEVGELKQQINDLYSTLlrtiddlEf 220
Cdd:PRK10549 166 SWLIvalSTLLAALATFLLARGL---LAPVKRLVEGTHKLaagDFTTRVTPTSRDELGRLAQDFNQLASTL-------E- 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 221 KNkeilklEKLKYDFFKGASHELKTPLASLKIILENMKYNIGKYKERDiyINECIEIVDSLTKNISQI--LSVHSIENLN 298
Cdd:PRK10549 235 KN------EQMRRDFMADISHELRTPLAVLRGELEAIQDGVRKFTPES--VASLQAEVGTLTKLVDDLhqLSLSDEGALA 306
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 299 NDEEYLKINDTLEDILKKYEILANQKKITVNNYILDENVYIG-KTALKIILSNLISNAVKYTDVNGVINIGIVND----W 373
Cdd:PRK10549 307 YRKTPVDLVPLLEVAGGAFRERFASRGLTLQLSLPDSATVFGdPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRdktlR 386
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 488229286 374 LYIENSYGNNKISNMDKIFDvKFdLNKENS-------NGLGLYIVSNILNNYN 419
Cdd:PRK10549 387 LTFADSAPGVSDEQLQKLFE-RF-YRTEGSrnrasggSGLGLAICLNIVEAHN 437
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
240-415 |
1.99e-09 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 59.21 E-value: 1.99e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 240 SHELKTPLASLKIILENMKYNIGKYKERDI-YINECIEI----VDSLTKNISQILSVHSIENLNNDEEYLkiNDTLEDIL 314
Cdd:COG5000 209 AHEIKNPLTPIQLSAERLRRKLADKLEEDReDLERALDTiirqVDRLKRIVDEFLDFARLPEPQLEPVDL--NELLREVL 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 315 KKYEILANQKKITVNNYILDE--NVYIGKTALKIILSNLISNAVKYTDVNGVINI--GIVNDWLYIEnsygnnkIS---- 386
Cdd:COG5000 287 ALYEPALKEKDIRLELDLDPDlpEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVstRREDGRVRIE-------VSdngp 359
|
170 180 190
....*....|....*....|....*....|....
gi 488229286 387 -----NMDKIFDVKFDlNKENSNGLGLYIVSNIL 415
Cdd:COG5000 360 gipeeVLERIFEPFFT-TKPKGTGLGLAIVKKIV 392
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
124-414 |
6.18e-08 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 55.03 E-value: 6.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 124 LQFVSTADMQKDAKDLSLKFLPYSLLISILFSAIISLIY----AKSIKNNIQEIKivTDKMMKLDKKmsLKVSSNDEVGE 199
Cdd:PRK15347 279 VTLYPRRNLANEALKPALQQLPFALLILVLLTSVLFLLLrrylAKPLWRFVDIIN--KTGPAALEPR--LPENRLDELGS 354
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 200 LKQQINDLYSTLLRTIDDLEFKNKE-ILKLE----------KLKYDFFKGASHELKTPL----ASLKiILENMKYNIGKY 264
Cdd:PRK15347 355 IAKAYNQLLDTLNEQYDTLENKVAErTQALAeakqraeqanKRKSEHLTTISHEIRTPLngvlGALE-LLQNTPLTAEQM 433
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 265 KERDIYINeCieiVDSLTKNISQILSVHSIEN----LNndEEYLKINDTLEDILKKYEILANQKKITVNNYILDE---NV 337
Cdd:PRK15347 434 DLADTARQ-C---TLSLLAIINNLLDFSRIESgqmtLS--LEETALLPLLDQAMLTIQGPAQSKSLTLRTFVGAHvplYL 507
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 338 YIGKTALKIILSNLISNAVKYTDVNGV-INIGIVNDWLY--IENSYGNNKISNMDKIFD--VKFDLNKENSnGLGLYIVS 412
Cdd:PRK15347 508 HLDSLRLRQILVNLLGNAVKFTETGGIrLRVKRHEQQLCftVEDTGCGIDIQQQQQIFTpfYQADTHSQGT-GLGLTIAS 586
|
..
gi 488229286 413 NI 414
Cdd:PRK15347 587 SL 588
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
192-414 |
7.85e-08 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 53.82 E-value: 7.85e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 192 SSNDEVGELKQQINDLYSTLLRTIDDlefknkeilklEKLkydFFKGASHELKTPLASLKIILENMKynigkyKERDIYI 271
Cdd:PRK10755 111 SSTLEIEAVTSALNQLVSRLTSTLDQ-----------ERL---FTADVAHELRTPLAGIRLHLELLE------KQHHIDV 170
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 272 NECIEIVDSLTKNISQILSVHSIENLNNDEEYLKInDTLED-ILKKYEIL-----ANQKKITVNNYILDENVYIGKTALK 345
Cdd:PRK10755 171 APLIARLDQMMHTVEQLLQLARAGQSFSSGHYQTV-KLLEDvILPSQDELsemleQRQQTLLLPESAADITVQGDATLLR 249
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488229286 346 IILSNLISNAVKYTDVNGVINIGIVND----WLYIENSyGN----NKISNMDKIFdVKFDlNKENSNGLGLYIVSNI 414
Cdd:PRK10755 250 LLLRNLVENAHRYSPEGSTITIKLSQEdggaVLAVEDE-GPgideSKCGELSKAF-VRMD-SRYGGIGLGLSIVSRI 323
|
|
| ArsS_fam_HK |
NF038389 |
ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase ... |
11-434 |
8.28e-08 |
|
ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase participating in a two-component system that controls the response to acid conditiions encountered during the process of gastric colonization. This HMM identified ArsS itself but also a broader collection of apparent orthologs from closely related non-gastric colonizers such as Helicobacter hepaticus, Campylobacter jejuni and Wolinella succinogenes. See BlastRule NBR014349 for specific identification of ArsS itself, distinguished by a signature His residue that becomes protonated at low pH.
Pssm-ID: 468500 [Multi-domain] Cd Length: 402 Bit Score: 54.08 E-value: 8.28e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 11 FIQIFSVLGIIIILVhSLIFFIFPKTYLETRKEKIHNMANEISSNMNGKEIKYI-EQTLEFYSKSSEIKVFIKEKNNKNE 89
Cdd:NF038389 4 FFKITILFAIALVSV-SALFLILLKYQKENYNEELNKKYSLIANTLLQLYQKNInEEELEKYLKNFGFMPITDKKLEKEI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 90 IQIKDNINVNLESDSNSLIIEEREIKLndgkktnlqFVSTADMQKDAKDLSLKFLPYSLLI--SILFSAIISLIYAkSIK 167
Cdd:NF038389 83 LEIGKNKFILKENGSFRILKYNDKIYL---------LIKNDGFSLLLEDNEKKSYRYYYIIvfFIFLILLLLILYI-SVL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 168 NNIQEIKIVTDKMMKL---DKKMSLKVSSNDEVGELKQQINDLYStllrtiddlefKNKEILKLEKLkydFFKGASHELK 244
Cdd:NF038389 153 KSLKPLKKLKKQIKKFangDFDFIKSESNGDEIGEVANEFDKAVK-----------KIKALNESRQL---FLRNIMHELK 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 245 TPLASLKIILENMKYNigKYKERDIYINECIEI-VDSLTKnISQILSVHSienLNNDEEYlkindTLEDILKKYEILA-- 321
Cdd:NF038389 219 TPITKGRIVAEMLEDE--KQKERLISIFERLESlINEFAK-IEQLTSKNY---KLNKKEY-----RLSDIIDEAIDMLmi 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 322 ----NQKKITVNNYILDENVYIGKTALKiilsNLISNAVKYTDvNGVINIGIVNDWLYIENSyGN---NKISNMDKIFdV 394
Cdd:NF038389 288 ddssVIIKVSLEDFKLNVDFELFSLAIK----NLIDNAIKYSP-DKKVTIEIKGDKIEFKNK-GEpleEPLEYYFEPF-F 360
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 488229286 395 KFDLNKENSNGLGLYIVSNIL--NNYNIEYKVLQDEEFFIFK 434
Cdd:NF038389 361 KGNEKSKSGFGLGLYIVKNILkaHGFKLEYEYENGYNIFIIK 402
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
229-291 |
1.53e-07 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 47.98 E-value: 1.53e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488229286 229 EKLKYDFFKGASHELKTPLASLKIILENMKYNIGKYKERDIYINECIEIVDSLTKNISQILSV 291
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDL 63
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
149-372 |
3.07e-07 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 52.81 E-value: 3.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 149 LISILFSAIISLIYAKSIKNNIQEIKIVTDKMMKLDKKMSLKVSSNDEVGELKQQINDLYSTLLRTIDDLEfkNKEILKL 228
Cdd:COG2770 219 LLALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPVSRKDEIGELARAFNRMADSLRESIEEAE--EEEELAE 296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 229 EKLKYDFFKGASHELKTPLASLKIILENMKYNIGKYKERDIYINECIEIVDSLTKNISQILSVHSIENLNNDEEYLKIND 308
Cdd:COG2770 297 AELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAALLLLLALELLLEAELLVL 376
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488229286 309 TLEDILKKYEILANQKKITVNNYILDENVYIGKTALKIILSNLISNAVKYTDVNGVINIGIVND 372
Cdd:COG2770 377 LALEALALEAELAAVLALLAALAAALLLLELALEELVLALLALALLALAAAAAAAEAAAAALEL 440
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
343-437 |
5.79e-07 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 48.03 E-value: 5.79e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 343 ALKIILSNLISNAVKYTDVNGVINIGI--VNDWLYIENSygNN----KISNMDKIFD----VKFDLNKENSNGLGLYIVS 412
Cdd:smart00387 5 RLRQVLSNLLDNAIKYTPEGGRITVTLerDGDHVEITVE--DNgpgiPPEDLEKIFEpffrTDKRSRKIGGTGLGLSIVK 82
|
90 100
....*....|....*....|....*...
gi 488229286 413 NILNNYNIEYKVLQDEE---FFIFKIKI 437
Cdd:smart00387 83 KLVELHGGEISVESEPGggtTFTITLPL 110
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
238-419 |
1.28e-06 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 50.18 E-value: 1.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 238 GASHELKTPLASLKIILENMKYNIGKYKERDiYINECIEIVDSLTKNISQIlsvhsIENLNN----DEEYLK---INDTL 310
Cdd:COG4191 148 GIAHEINNPLAAILGNAELLRRRLEDEPDPE-ELREALERILEGAERAAEI-----VRSLRAfsrrDEEEREpvdLNELI 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 311 EDILKKYEILANQKKITVnNYILDEN---VYIGKTALKIILSNLISNAVkytD-----VNGVINI--GIVNDWLYIE--- 377
Cdd:COG4191 222 DEALELLRPRLKARGIEV-ELDLPPDlppVLGDPGQLEQVLLNLLINAI---DameegEGGRITIstRREGDYVVISvrd 297
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 488229286 378 NSYGnnkIS--NMDKIFDvKFDLNKENSN--GLGLYIVSNILNNYN 419
Cdd:COG4191 298 NGPG---IPpeVLERIFE-PFFTTKPVGKgtGLGLSISYGIVEKHG 339
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
260-437 |
4.78e-06 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 48.69 E-value: 4.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 260 NIGKYKERDIYINECIEIVDSLTKNISQILSvhsienlnndeeylkiNDTLEDILKKYEILANQKKITVNnyiLDENVYI 339
Cdd:COG3290 212 QLGEYDEALEYIDEISEELQELIDSLLSRIG----------------NPVLAALLLGKAARARERGIDLT---IDIDSDL 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 340 GKTALK-----IILSNLISNAV----KYTDVNGVINIGIV--NDWLYIE--NSYGNNKISNMDKIFDVKFDLNKENSNGL 406
Cdd:COG3290 273 PDLPLSdtdlvTILGNLLDNAIeaveKLPEEERRVELSIRddGDELVIEveDSGPGIPEELLEKIFERGFSTKLGEGRGL 352
|
170 180 190
....*....|....*....|....*....|..
gi 488229286 407 GLYIVSNILNNYNIEYKVLQDEEFF-IFKIKI 437
Cdd:COG3290 353 GLALVKQIVEKYGGTIEVESEEGEGtVFTVRL 384
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
215-417 |
6.90e-06 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 48.58 E-value: 6.90e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 215 IDDLEFKNKEILKLEKLKYDFFKGASHELKTPLASLKIILENMKYNIGKYKERDIYINECIEIVDSLTKNISQILSVHSI 294
Cdd:PRK09959 695 IHALEVERNKAINATVAKSQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKI 774
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 295 E--NLNNDEEYLKINDTLEDILKKYEILANQKKITVNNYILDENVYIGK---TALKIILSNLISNAVKYTDVNGViniGI 369
Cdd:PRK09959 775 EsgNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALSCSSTFPDHYLVKidpQAFKQVLSNLLSNALKFTTEGAV---KI 851
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488229286 370 VNDWLYIENSYGNNKISNMD--------------KIFDVKFDLNKENSNGLGLYIVSNILNN 417
Cdd:PRK09959 852 TTSLGHIDDNHAVIKMTIMDsgsglsqeeqqqlfKRYSQTSAGRQQTGSGLGLMICKELIKN 913
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
227-359 |
9.58e-06 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 47.70 E-value: 9.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 227 KLEKLKYDFFKGASHELKTPLASLKIILENMKYN--IGKYKERDIY-INECIEIVDSLTKnisQILSVHSIE-----NLN 298
Cdd:PRK11006 199 QLEGARRNFFANVSHELRTPLTVLQGYLEMMQDQplEGALREKALHtMREQTQRMEGLVK---QLLTLSKIEaaptiDLN 275
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488229286 299 ndeEYLKINDTLEDILKKYEILANQK-KITVNnyiLDEN--VYIGKTALKIILSNLISNAVKYT 359
Cdd:PRK11006 276 ---EKVDVPMMLRVLEREAQTLSQGKhTITFE---VDNSlkVFGNEDQLRSAISNLVYNAVNHT 333
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
240-376 |
2.84e-05 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 46.08 E-value: 2.84e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 240 SHELKTPLASLKIILENMKYNIGKYKERdiyinECIEI-VDSLTKNISQILsVHSIENLNN--DEEYLKINDTLEDILK- 315
Cdd:PRK09470 251 SHELRTPLTRLQLATALLRRRQGESKEL-----ERIETeAQRLDSMINDLL-VLSRNQQKNhlERETFKANSLWSEVLEd 324
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488229286 316 -KYEILANQKKITVN----NYILDENvyigKTALKIILSNLISNAVKYTDVNGVINIGIVNDWLYI 376
Cdd:PRK09470 325 aKFEAEQMGKSLTVSappgPWPINGN----PNALASALENIVRNALRYSHTKIEVAFSVDKDGLTI 386
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
342-436 |
5.78e-05 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 41.97 E-value: 5.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 342 TALKIILSNLISNAVKYTDVNGVINIGI-VNDWLYIEnsygnnkISN---------MDKIFDvKF---DLNKENSNGLGL 408
Cdd:pfam02518 4 LRLRQVLSNLLDNALKHAAKAGEITVTLsEGGELTLT-------VEDngigippedLPRIFE-PFstaDKRGGGGTGLGL 75
|
90 100 110
....*....|....*....|....*....|.
gi 488229286 409 YIVSNILNNYNIEYKVLQDEE---FFIFKIK 436
Cdd:pfam02518 76 SIVRKLVELLGGTITVESEPGggtTVTLTLP 106
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
344-424 |
1.76e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 40.73 E-value: 1.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 344 LKIILSNLISNAVKYTDVNGVINIGIVND----WLYIENSYGNNKISNMDKIFDVKF----DLNKENSNGLGLYIVSNIL 415
Cdd:cd16948 6 LSFIIGQIVSNALKYSKQGGKIEIYSETNeqgvVLSIKDFGIGIPEEDLPRVFDKGFtgenGRNFQESTGMGLYLVKKLC 85
|
....*....
gi 488229286 416 NNYNIEYKV 424
Cdd:cd16948 86 DKLGHKIDV 94
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
164-419 |
3.75e-04 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 42.80 E-value: 3.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 164 KSIKNNIQEIKIVTDKMMKLDKKMSLKVSSNDEVGELKQQIndLYSTLLRTIDDLEFKNKEILKLEKLKY--DFFKGASH 241
Cdd:COG5805 219 ESITEVWQEFIIEREIITKDGRIRYFEAVIVPLIDTDGSVK--GILVILRDITEKKEAEELMARSEKLSIagQLAAGIAH 296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 242 ELKTPLASLKIILENMKYNIGKYKErdiYINECIEIVDSLTKNISQILSVHsiENLNNDEEYLKINDTLEDILKKYEILA 321
Cdd:COG5805 297 EIRNPLTSIKGFLQLLQPGIEDKEE---YFDIMLSELDRIESIISEFLALA--KPQAVNKEKENINELIQDVVTLLETEA 371
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 322 NQKKITVNNYILDE--NVYIGKTALKIILSNLISNAVKYTDVNGVINIGIVNDWLYIENSYGNNKI----SNMDKIFDvK 395
Cdd:COG5805 372 ILHNIQIRLELLDEdpFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIgipeERLKKLGE-P 450
|
250 260
....*....|....*....|....
gi 488229286 396 FDLNKENSNGLGLYIVSNILNNYN 419
Cdd:COG5805 451 FFTTKEKGTGLGLMVSYKIIENHN 474
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
47-218 |
6.86e-04 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 41.93 E-value: 6.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 47 NMANEISSNMNGKEIKYIEQTLEFYSKSSEIKVFIKEKNNKNEIQIKDNINVNLESDSNSLIIEEREIKLNDGKKTNLQF 126
Cdd:COG0840 87 ALLLLLLALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAALAAL 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 127 VSTADMQKDAKDLSLKFLPYSLLISILFSAIISLIYAKSIKNNIQEIKIVTDKMMKLDKKMSLKVSSNDEVGELKQQIND 206
Cdd:COG0840 167 LEAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNR 246
|
170
....*....|..
gi 488229286 207 LYSTLLRTIDDL 218
Cdd:COG0840 247 MIENLRELVGQV 258
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
238-419 |
7.37e-04 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 41.88 E-value: 7.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 238 GASHELKTPLASLK----IILENMKYnigkyKERDIYINECIEIVDSLTKNISQIL-----SVHSIENLNndeeylkIND 308
Cdd:PRK11360 396 GVAHEIRNPLTAIRgyvqIWRQQTSD-----PPSQEYLSVVLREVDRLNKVIDQLLefsrpRESQWQPVS-------LNA 463
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 309 TLEDILKKYEILANQKKITVNNyILDEN---VYIGKTALKIILSNLISNAVKYTDVNGVINIgivNDWLYIEN----SYG 381
Cdd:PRK11360 464 LVEEVLQLFQTAGVQARVDFET-ELDNElppIWADPELLKQVLLNILINAVQAISARGKIRI---RTWQYSDGqvavSIE 539
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 488229286 382 NN----KISNMDKIFDvKFDLNKENSNGLGLYIVSNILNNYN 419
Cdd:PRK11360 540 DNgcgiDPELLKKIFD-PFFTTKAKGTGLGLALSQRIINAHG 580
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
235-414 |
8.24e-04 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 41.56 E-value: 8.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 235 FFKGASHELKTPLASLKIILENMKYNIGKYKERDIYINECIEIVDSLTKNISQILSVHSIENLNN--DEEYLKINDTLED 312
Cdd:PRK10337 240 FTSDAAHELRSPLAALKVQTEVAQLSDDDPQARKKALLQLHAGIDRATRLVDQLLTLSRLDSLDNlqDVAEIPLEDLLQS 319
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 313 ILKKYEILANQKKITVNnyiLDENVY-IGKTALKIILS----NLISNAVKYTDVNGVINIGIVNDWLYIENSygNNKISN 387
Cdd:PRK10337 320 AVMDIYHTAQQAGIDVR---LTLNAHpVIRTGQPLLLSllvrNLLDNAIRYSPQGSVVDVTLNARNFTVRDN--GPGVTP 394
|
170 180 190
....*....|....*....|....*....|..
gi 488229286 388 --MDKIFDvKF---DLNKENSNGLGLYIVSNI 414
Cdd:PRK10337 395 eaLARIGE-RFyrpPGQEATGSGLGLSIVRRI 425
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
232-296 |
8.33e-04 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 37.55 E-value: 8.33e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488229286 232 KYDFFKGASHELKTPLASLKIILENMKYNIGKYKERDiYINECIEIVDSLTKNISQILSVHSIEN 296
Cdd:smart00388 2 KREFLANLSHELRTPLTAIRGYLELLLDTELSEEQRE-YLETILREAERLLRLINDLLDLSRIEA 65
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
232-296 |
8.82e-04 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 37.58 E-value: 8.82e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488229286 232 KYDFFKGASHELKTPLASLKIILENMKyNIGKYKERDIYINECIEIVDSLTKNISQILSVHSIEN 296
Cdd:pfam00512 2 KSEFLANLSHELRTPLTAIRGYLELLR-DEKLDEEQREYLETILRSAERLLRLINDLLDLSRIEA 65
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
229-415 |
1.89e-03 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 40.79 E-value: 1.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 229 EKLKYDFFKGASHELKTPLASL----KIILENMKYNIGKYKERdiyINECIEIVDSLTKNISQILSVHSIE----NLNnd 300
Cdd:PRK10490 661 EQLRNALLAALSHDLRTPLTVLfgqaEILTLDLASEGSPHARQ---ASEIRQQVLNTTRLVNNLLDMARIQsggfNLR-- 735
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 301 EEYLkindTLEDI----LKKYEILANQKKITVNnyiLDEN---VYIGKTALKIILSNLISNAVKYTDVNGVINIG--IVN 371
Cdd:PRK10490 736 KEWL----TLEEVvgsaLQMLEPGLSGHPINLS---LPEPltlIHVDGPLFERVLINLLENAVKYAGAQAEIGIDahVEG 808
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 488229286 372 DWLYIENSYGNNKI--SNMDKIFDvKFDL-NKENS---NGLGLYIVSNIL 415
Cdd:PRK10490 809 ERLQLDVWDNGPGIppGQEQLIFD-KFARgNKESAipgVGLGLAICRAIV 857
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
136-231 |
2.12e-03 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 40.25 E-value: 2.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 136 AKDLSLKFLPYSLLISILFSAIISLIYAKSIKNNIQEIKIVTDKMMKLDKKMSLKVSSNDEVGELKQQINDLYSTLLRTI 215
Cdd:COG3850 112 AAAINRKLALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVSGRDELGTLARAFNRMADELQELY 191
|
90
....*....|....*.
gi 488229286 216 DDLEFKNKEILKLEKL 231
Cdd:COG3850 192 AELEEEEELEAELELL 207
|
|
| HATPase_c_5 |
pfam14501 |
GHKL domain; This family represents the structurally related ATPase domains of histidine ... |
344-437 |
2.28e-03 |
|
GHKL domain; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 433996 [Multi-domain] Cd Length: 102 Bit Score: 37.19 E-value: 2.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 344 LKIILSNLISNA---VKYTDVNGVIN--IGIVNDWLYI--ENSYgNNKISNMDKIFDVKfdlNKENSNGLGLYIVSNILN 416
Cdd:pfam14501 6 LCVIFGNLLDNAieaCSKIDDNRFIRlkIREKQNFLIIriENTY-EGELKFEGKLPSTK---TKGDGHGIGLKSIRRIVK 81
|
90 100
....*....|....*....|.
gi 488229286 417 NYNIEYKVLQDEEFFIFKIKI 437
Cdd:pfam14501 82 KYGGNLSTEIENGIFTLSILL 102
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
204-419 |
2.58e-03 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 39.96 E-value: 2.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 204 INDLYSTLLRTIDDLEFKNKEILKLEKLKY--DFFKGASHELKTPLASLKIILENMKYNIgkYKERDIYINECIEIVDSL 281
Cdd:COG5809 240 EVDGIVIIFRDITERKKLEELLRKSEKLSVvgELAAGIAHEIRNPLTSLKGFIQLLKDTI--DEEQKTYLDIMLSELDRI 317
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 282 TKNISQILSVHSIENLNndEEYLKINDTLEDILKKYEILANQKKITVNNYILDENVYIG--KTALKIILSNLISNAVKYT 359
Cdd:COG5809 318 ESIISEFLVLAKPQAIK--YEPKDLNTLIEEVIPLLQPQALLKNVQIELELEDDIPDILgdENQLKQVFINLLKNAIEAM 395
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488229286 360 DVNGVINIGIvndwlyieNSYGNNKI-------------SNMDKIFDvKFDLNKENSNGLGLYIVSNILNNYN 419
Cdd:COG5809 396 PEGGNITIET--------KAEDDDKVvisvtdegcgipeERLKKLGE-PFYTTKEKGTGLGLMVSYKIIEEHG 459
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
195-369 |
2.67e-03 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 39.93 E-value: 2.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 195 DEVGELKQQINDLystllrtIDDLEFKNKEILKLeklkydffkgaSHELKTPLASLKIILENMKynIGKYKERDIYINEC 274
Cdd:PRK09303 132 DELFVLRQENETL-------LEQLKFKDRVLAML-----------AHDLRTPLTAASLALETLE--LGQIDEDTELKPAL 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 275 I-----------EIVDSLTKNISQIlSVHSIENLNNDEEYLKINDTLEDILKKYEILANQKKITVNNYI-LD-ENVYIGK 341
Cdd:PRK09303 192 IeqlqdqarrqlEEIERLITDLLEV-GRTRWEALRFNPQKLDLGSLCQEVILELEKRWLAKSLEIQTDIpSDlPSVYADQ 270
|
170 180
....*....|....*....|....*...
gi 488229286 342 TALKIILSNLISNAVKYTDVNGVINIGI 369
Cdd:PRK09303 271 ERIRQVLLNLLDNAIKYTPEGGTITLSM 298
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
347-437 |
3.16e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 36.98 E-value: 3.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 347 ILSNLISNAVKYTDVNGVINIGIvndwlYIENSYGNNKISNM---------DKIFD--VKFDlNKENSN--GLGLYIVSN 413
Cdd:cd16923 4 VFSNLLSNAIKYSPENTRIYITS-----FLTDDVVNIMFKNPsshpldfklEKLFErfYRGD-NSRNTEgaGLGLSIAKA 77
|
90 100
....*....|....*....|....
gi 488229286 414 ILNNYNIEYKVLQDEEFFIFKIKI 437
Cdd:cd16923 78 IIELHGGSASAEYDDNHDLFKVRL 101
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
341-421 |
3.79e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 37.00 E-value: 3.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 341 KTALKIILSNLISNAVKYTDVNGVINIGIVNDW---LYIENSYGNNKISNMDKIFD--VKFDLNKENSNGLGLYIVSNI- 414
Cdd:cd16940 11 ALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDgavIRVEDNGPGIDEEELEALFErfYRSDGQNYGGSGLGLSIVKRIv 90
|
....*...
gi 488229286 415 -LNNYNIE 421
Cdd:cd16940 91 eLHGGQIF 98
|
|
| HATPase_AgrC-ComD-like |
cd16935 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
313-437 |
8.52e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.
Pssm-ID: 340412 [Multi-domain] Cd Length: 134 Bit Score: 36.40 E-value: 8.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488229286 313 ILKKYEILANQKKITVN-NYILDENVYIGKTALKIILSNLISNAV----KYTDVNGVI--NIGIVNDWLYI--ENSYgNN 383
Cdd:cd16935 5 LLSEKLELAREKGIEFTiEIDIPILLPISPLDLCIIFGNLLDNAIeacaKIDKENRFIhlKIRQKKGFLIIsiENSY-EG 83
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 488229286 384 KIsnmDKIFDVKFDLNKENSNGLGLYIVSNILNNYNIEYKVLQDEEFFIFKIKI 437
Cdd:cd16935 84 EL---KKKNGLFLSTKKDKNHGIGLKSIREIVKKYNGNLSIEYENGIFTLSILL 134
|
|
| |
