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Concise Results
Standard Results
Full Results
pyruvate dehydrogenase (acetyl-transferring), homodimeric type [Neisseria meningitidis]
Protein Classification
AceE family protein ( domain architecture ID 11457666 )
AceE family protein
List of domain hits
Name
Accession
Description
Interval
E-value
AceE
COG2609 Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion] ...
2-887
0e+00
Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion]; Pyruvate dehydrogenase complex, dehydrogenase (E1) component is part of the Pathway/BioSystem: Pyruvate oxidation
Pssm-ID: 442021 [Multi-domain]
Cd Length: 891
Bit Score: 1885.17
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 2 ST QL H D V DP I ETQEWL DA L SS V L E Y EG G ERA Q YLLE N L VKYC R DK GV RM P HGT TTPY L NT VS VE N E KGI PGD QNI E H RIR 81
Cdd:COG2609 7 PS QL P D I DP Q ETQEWL ES L DA V I E E EG P ERA R YLLE R L LERA R RS GV GL P FSA TTPY I NT IP VE Q E PPY PGD EEL E R RIR 86
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 82 AFV RWNA A A I V L RA GK K DLE LGGHI A SF Q SAAT M YEVGFNHF WKAKGEGEE GDLV F FQGH VA PGIYARAF V EGRLTE D QL 161
Cdd:COG2609 87 SII RWNA M A M V V RA NR K GGG LGGHI S SF A SAAT L YEVGFNHF FRGPDHPGG GDLV Y FQGH AS PGIYARAF L EGRLTE E QL 166
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 162 N NFRQEVDG H GL P SYPHP H L L PDFWQFPTVSMGLGPI M AIYQARF L KYL ES RGL AK T KG RKVW C F C GDGEMDEPES Q GAI 241
Cdd:COG2609 167 D NFRQEVDG K GL S SYPHP W L M PDFWQFPTVSMGLGPI N AIYQARF M KYL HN RGL KD T SD RKVW A F L GDGEMDEPES L GAI 246
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 242 A LAARE G LDNLIFVINCNLQRLDGPVRGNGKIIQELEG N F A GAGWNV V KVIWG RR WD R LLAKD K DG I L RQ RM E E CL DGDY 321
Cdd:COG2609 247 S LAARE K LDNLIFVINCNLQRLDGPVRGNGKIIQELEG V F R GAGWNV I KVIWG SE WD P LLAKD T DG A L VK RM N E TV DGDY 326
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 322 QTYK S KDGAYVREHFF NT - PELKALVADM T DE QL W A LNRGGHDP Q KVY N AY DR A AN H a D G K PTVILAKTIKGYGMG AS GE 400
Cdd:COG2609 327 QTYK A KDGAYVREHFF GK y PELKALVADM S DE DI W R LNRGGHDP R KVY A AY KA A VE H - K G Q PTVILAKTIKGYGMG EA GE 405
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 401 G Q N VA HQ A KK M D KAS LK Q FRDRF D IP VT DEQ I E sg D LPY LTF A P D TE E Y KYLH A RR D ALGGYLPQR KPTQ E V LEVPELSA 480
Cdd:COG2609 406 G R N IT HQ Q KK L D LDD LK A FRDRF N IP IS DEQ L E -- E LPY YKP A E D SP E M KYLH E RR K ALGGYLPQR RTKA E P LEVPELSA 483
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 481 F D A Q LK S SG E RE F STTMAFVRIL ST LLKDK K IGKR V VPIVPDE S RTFGMEG M FRQ Y GI WN P K GQ Q YTP Q D K DQL MF YKES 560
Cdd:COG2609 484 F A A L LK G SG K RE I STTMAFVRIL ND LLKDK E IGKR I VPIVPDE A RTFGMEG L FRQ I GI YS P V GQ L YTP V D A DQL LY YKES 563
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 561 V DGQILQEGINE P GAM AD WIAA A TSY ANSDFA MIPFYIYYSMFGFQR I GDLAWAAGD MH ARGFL L G G TAGRTTLNGEGLQ 640
Cdd:COG2609 564 K DGQILQEGINE A GAM SS WIAA G TSY STHGVP MIPFYIYYSMFGFQR V GDLAWAAGD QR ARGFL I G A TAGRTTLNGEGLQ 643
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 641 H E DGHSH IQ A DL IPNCVSYDP T F Q YE V AVIVQDGLRRMY ANN E D VFYYIT L MNENY TH P D MPEG A E QD ILKGMYLLK A G G 720
Cdd:COG2609 644 H Q DGHSH LL A ST IPNCVSYDP A F A YE L AVIVQDGLRRMY GEQ E N VFYYIT V MNENY AQ P A MPEG V E EG ILKGMYLLK E G E 723
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 721 KGD K - K VQL M GSGTIL Q EV VTG AELL KA D F GV E AD I WS CP SFN L L H RD AVE VER F N R LHP L E AEK VP F VT SK L Q G HD GPV 799
Cdd:COG2609 724 GKG K p R VQL L GSGTIL R EV LAA AELL AE D W GV A AD V WS VT SFN E L R RD GLD VER W N L LHP E E EPR VP Y VT QC L A G AE GPV 803
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 800 I AATDY I R SYA D R IR AYI P ND Y H VLGTDGFGRSD S R AN LRRFFEVDRY NVA VAAL S ALA EQ GK VSKET V QQ AI E KYGI KA 879
Cdd:COG2609 804 V AATDY M R AVP D Q IR PWV P GR Y T VLGTDGFGRSD T R EA LRRFFEVDRY SIV VAAL K ALA DE GK IDASV V AE AI K KYGI DP 883
....*...
gi 488158357 880 D SAPSWKR 887
Cdd:COG2609 884 D KPNPLTA 891
Name
Accession
Description
Interval
E-value
AceE
COG2609 Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion] ...
2-887
0e+00
Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion]; Pyruvate dehydrogenase complex, dehydrogenase (E1) component is part of the Pathway/BioSystem: Pyruvate oxidation
Pssm-ID: 442021 [Multi-domain]
Cd Length: 891
Bit Score: 1885.17
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 2 ST QL H D V DP I ETQEWL DA L SS V L E Y EG G ERA Q YLLE N L VKYC R DK GV RM P HGT TTPY L NT VS VE N E KGI PGD QNI E H RIR 81
Cdd:COG2609 7 PS QL P D I DP Q ETQEWL ES L DA V I E E EG P ERA R YLLE R L LERA R RS GV GL P FSA TTPY I NT IP VE Q E PPY PGD EEL E R RIR 86
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 82 AFV RWNA A A I V L RA GK K DLE LGGHI A SF Q SAAT M YEVGFNHF WKAKGEGEE GDLV F FQGH VA PGIYARAF V EGRLTE D QL 161
Cdd:COG2609 87 SII RWNA M A M V V RA NR K GGG LGGHI S SF A SAAT L YEVGFNHF FRGPDHPGG GDLV Y FQGH AS PGIYARAF L EGRLTE E QL 166
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 162 N NFRQEVDG H GL P SYPHP H L L PDFWQFPTVSMGLGPI M AIYQARF L KYL ES RGL AK T KG RKVW C F C GDGEMDEPES Q GAI 241
Cdd:COG2609 167 D NFRQEVDG K GL S SYPHP W L M PDFWQFPTVSMGLGPI N AIYQARF M KYL HN RGL KD T SD RKVW A F L GDGEMDEPES L GAI 246
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 242 A LAARE G LDNLIFVINCNLQRLDGPVRGNGKIIQELEG N F A GAGWNV V KVIWG RR WD R LLAKD K DG I L RQ RM E E CL DGDY 321
Cdd:COG2609 247 S LAARE K LDNLIFVINCNLQRLDGPVRGNGKIIQELEG V F R GAGWNV I KVIWG SE WD P LLAKD T DG A L VK RM N E TV DGDY 326
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 322 QTYK S KDGAYVREHFF NT - PELKALVADM T DE QL W A LNRGGHDP Q KVY N AY DR A AN H a D G K PTVILAKTIKGYGMG AS GE 400
Cdd:COG2609 327 QTYK A KDGAYVREHFF GK y PELKALVADM S DE DI W R LNRGGHDP R KVY A AY KA A VE H - K G Q PTVILAKTIKGYGMG EA GE 405
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 401 G Q N VA HQ A KK M D KAS LK Q FRDRF D IP VT DEQ I E sg D LPY LTF A P D TE E Y KYLH A RR D ALGGYLPQR KPTQ E V LEVPELSA 480
Cdd:COG2609 406 G R N IT HQ Q KK L D LDD LK A FRDRF N IP IS DEQ L E -- E LPY YKP A E D SP E M KYLH E RR K ALGGYLPQR RTKA E P LEVPELSA 483
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 481 F D A Q LK S SG E RE F STTMAFVRIL ST LLKDK K IGKR V VPIVPDE S RTFGMEG M FRQ Y GI WN P K GQ Q YTP Q D K DQL MF YKES 560
Cdd:COG2609 484 F A A L LK G SG K RE I STTMAFVRIL ND LLKDK E IGKR I VPIVPDE A RTFGMEG L FRQ I GI YS P V GQ L YTP V D A DQL LY YKES 563
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 561 V DGQILQEGINE P GAM AD WIAA A TSY ANSDFA MIPFYIYYSMFGFQR I GDLAWAAGD MH ARGFL L G G TAGRTTLNGEGLQ 640
Cdd:COG2609 564 K DGQILQEGINE A GAM SS WIAA G TSY STHGVP MIPFYIYYSMFGFQR V GDLAWAAGD QR ARGFL I G A TAGRTTLNGEGLQ 643
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 641 H E DGHSH IQ A DL IPNCVSYDP T F Q YE V AVIVQDGLRRMY ANN E D VFYYIT L MNENY TH P D MPEG A E QD ILKGMYLLK A G G 720
Cdd:COG2609 644 H Q DGHSH LL A ST IPNCVSYDP A F A YE L AVIVQDGLRRMY GEQ E N VFYYIT V MNENY AQ P A MPEG V E EG ILKGMYLLK E G E 723
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 721 KGD K - K VQL M GSGTIL Q EV VTG AELL KA D F GV E AD I WS CP SFN L L H RD AVE VER F N R LHP L E AEK VP F VT SK L Q G HD GPV 799
Cdd:COG2609 724 GKG K p R VQL L GSGTIL R EV LAA AELL AE D W GV A AD V WS VT SFN E L R RD GLD VER W N L LHP E E EPR VP Y VT QC L A G AE GPV 803
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 800 I AATDY I R SYA D R IR AYI P ND Y H VLGTDGFGRSD S R AN LRRFFEVDRY NVA VAAL S ALA EQ GK VSKET V QQ AI E KYGI KA 879
Cdd:COG2609 804 V AATDY M R AVP D Q IR PWV P GR Y T VLGTDGFGRSD T R EA LRRFFEVDRY SIV VAAL K ALA DE GK IDASV V AE AI K KYGI DP 883
....*...
gi 488158357 880 D SAPSWKR 887
Cdd:COG2609 884 D KPNPLTA 891
aceE
PRK09405 pyruvate dehydrogenase subunit E1; Reviewed
1-885
0e+00
pyruvate dehydrogenase subunit E1; Reviewed
Pssm-ID: 236500 [Multi-domain]
Cd Length: 891
Bit Score: 1857.88
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 1 MST QL H D V DPIETQEWL D AL S SV LEY EG G ERA Q YLLE N L VKYC R D KGV RM P HGT TTPY L NT VS VE N E KGI PGD QNI E H RI 80
Cdd:PRK09405 5 SES QL N D I DPIETQEWL E AL D SV IRE EG P ERA H YLLE Q L LERA R E KGV SL P ASA TTPY I NT IP VE E E PEY PGD LEL E R RI 84
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 81 R AFV RWNAAA I VLRA G KKDL E LGGHI A SF Q S A AT M YEVGFNHF WK A KG E GEE GDLVFFQGH VA PGIYARAF V EGRLTE D Q 160
Cdd:PRK09405 85 R SYI RWNAAA M VLRA N KKDL G LGGHI S SF A S S AT L YEVGFNHF FR A PN E PHG GDLVFFQGH AS PGIYARAF L EGRLTE E Q 164
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 161 L N NFRQEVDG H GL P SYPHP H L L PDFWQFPTVSMGLGPIMAIYQARFLKYLE S RGL AK T KGR KVW C F C GDGEMDEPES Q GA 240
Cdd:PRK09405 165 L D NFRQEVDG K GL S SYPHP W L M PDFWQFPTVSMGLGPIMAIYQARFLKYLE N RGL KD T SDQ KVW A F L GDGEMDEPES L GA 244
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 241 I A LAARE G LDNLIFVINCNLQRLDGPVRGNGKIIQELEG N F A GAGWNV V KVIWG R RWD R LLAKD KD G I L R Q R M E E CL DGD 320
Cdd:PRK09405 245 I S LAARE K LDNLIFVINCNLQRLDGPVRGNGKIIQELEG I F R GAGWNV I KVIWG S RWD P LLAKD TS G K L V Q L M N E TV DGD 324
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 321 YQTYK S KDGAYVREHFF - NT PE L KALVADM T D EQL WALNRGGHDP Q KVY N AY DR A AN H A d G K PTVILAKTIKGYGMG AS G 399
Cdd:PRK09405 325 YQTYK A KDGAYVREHFF g KY PE T KALVADM S D DDI WALNRGGHDP R KVY A AY KA A VE H K - G Q PTVILAKTIKGYGMG EA G 403
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 400 EG Q N V AHQ A KK M D KAS LK Q FRDRF D IP VT DEQ I E sg D LPY LTFAP D TE E Y KYLH A RR D ALGGYLP Q R K P TQ E V LEVP E LS 479
Cdd:PRK09405 404 EG K N I AHQ V KK L D LDD LK H FRDRF N IP IS DEQ L E -- K LPY YKPGE D SP E I KYLH E RR K ALGGYLP A R R P KF E P LEVP A LS 481
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 480 AF D A Q LK S SGERE F STTMAFVRIL ST LLKDK K IGKR V VPI V PDE S RTFGMEG M FRQ Y GI W NP K GQ Q YTP Q D K DQLM F YKE 559
Cdd:PRK09405 482 AF E A L LK G SGERE I STTMAFVRIL NI LLKDK E IGKR I VPI I PDE A RTFGMEG L FRQ I GI Y NP H GQ L YTP V D R DQLM Y YKE 561
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 560 S V DGQILQEGINE P GAMA D WIAAATSY ANSDFA MIPFYIYYSMFGFQRIGDLAWAAGD MH ARGFLLGGTAGRTTLNGEGL 639
Cdd:PRK09405 562 S K DGQILQEGINE A GAMA S WIAAATSY STHGEP MIPFYIYYSMFGFQRIGDLAWAAGD QR ARGFLLGGTAGRTTLNGEGL 641
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 640 QHEDGHSHI Q A DL IPNCVSYDP T F Q YEVAVIVQDGLRRMY ANN E D VFYYIT L MNENY TH P D MPEGAE QD ILKGMY L L K -- 717
Cdd:PRK09405 642 QHEDGHSHI L A ST IPNCVSYDP A F A YEVAVIVQDGLRRMY GEQ E N VFYYIT V MNENY HQ P A MPEGAE EG ILKGMY K L E ta 721
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 718 A G G KG DK KVQL M GSGTIL Q EV VTG AE L L KA D F GV E AD I WS CP SFN L L H RD AVE VER F N R LHP L E AEK VP F VT SK L Q G HD G 797
Cdd:PRK09405 722 E G K KG KP KVQL L GSGTIL R EV LEA AE I L AE D Y GV A AD V WS VT SFN E L A RD GQD VER W N M LHP T E EPR VP Y VT QV L K G AE G 801
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 798 PV I AATDY IRSY A DR IRA YI P N DY H VLGTDGFGRSD S R AN LRRFFEVD RYN V A VAAL S ALA EQ G KVSKET V QQ AI E KYGI 877
Cdd:PRK09405 802 PV V AATDY MKLF A EQ IRA FV P G DY V VLGTDGFGRSD T R EA LRRFFEVD AEY V V VAAL K ALA DE G EIDASV V AE AI K KYGI 881
....*...
gi 488158357 878 KA D S A PSW 885
Cdd:PRK09405 882 DP D K A NPR 889
aceE
TIGR00759 pyruvate dehydrogenase E1 component, homodimeric type; Most members of this family are ...
4-887
0e+00
pyruvate dehydrogenase E1 component, homodimeric type; Most members of this family are pyruvate dehydrogenase complex, E1 component. Note: this family was classified as subfamily rather than equivalog because it includes a counterexample from Pseudomonas putida, MdeB, that is active as an E1 component of an alpha-ketoglutarate dehydrogenase complex rather than a pyruvate dehydrogase complex. The second pyruvate dehydrogenase complex E1 protein from Alcaligenes eutrophus, PdhE, complements an aceE mutant of E. coli but is not part of a pyruvate dehydrogenase complex operon, is more similar to the Pseudomonas putida MdeB than to E. coli AceE, and may have also have a different primary specificity.
Pssm-ID: 273255 [Multi-domain]
Cd Length: 885
Bit Score: 1473.46
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 4 Q LH DVDPIETQEWL DA L S SVL EY EG GE RA Q YLLE N L VK Y C R DK GV RM P H GTTT P Y L NT VS VE NEKGI PGD QNI E H RIR AF 83
Cdd:TIGR00759 2 Q PN DVDPIETQEWL ES L D SVL AE EG PA RA R YLLE Q L LE Y A R EH GV PI P A GTTT D Y I NT IP VE EQPAY PGD LEL E R RIR SI 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 84 V RWNA A A I VLRA G KKDL E LGGHI ASFQ SAAT M YEVGFNHF WKAKG EG EE GDLVFFQGH V APGIYARAF V EGRLTE D QL N N 163
Cdd:TIGR00759 82 I RWNA I A M VLRA N KKDL G LGGHI STYA SAAT L YEVGFNHF FRGHS EG GG GDLVFFQGH A APGIYARAF L EGRLTE E QL D N 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 164 FRQEV D G H GL P SYPHP H L L PDFWQFPTVSMGLGPI M AIYQARF L KYLE S RGL AK T KGR KVW C F C GDGEMDEPES Q GAI AL 243
Cdd:TIGR00759 162 FRQEV Q G D GL S SYPHP W L M PDFWQFPTVSMGLGPI N AIYQARF M KYLE N RGL KD T GDQ KVW A F L GDGEMDEPES K GAI TF 241
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 244 AARE G LDNL I FVINCNLQRLDGPVRGNGKIIQELE GN F A GAGWNV V KV I WG RR WD R LLA K D KD G I L RQR M E E CL DGDYQT 323
Cdd:TIGR00759 242 AARE K LDNL T FVINCNLQRLDGPVRGNGKIIQELE SL F R GAGWNV I KV L WG SE WD A LLA R D TS G V L VKL M N E TV DGDYQT 321
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 324 YK S KDGAYVREHFFN - TPELKALVADM T D EQL WALNRGGHDP Q KVY N AY DR A AN H A d G K PTVILAKTIKGYGMG ASG E GQ 402
Cdd:TIGR00759 322 YK A KDGAYVREHFFN r TPELKALVADM S D ADI WALNRGGHDP R KVY A AY AA A QE H K - G Q PTVILAKTIKGYGMG DAA E SR 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 403 N V AHQ A KK MDKAS LK Q FRDRF DI P VT D E Q I E sg D LPY LTFAPDTE E YK YL H ARR D ALGGYLP Q R KPTQ E V L E VP E L SA F D 482
Cdd:TIGR00759 401 N T AHQ V KK LEVDA LK N FRDRF EL P LS D A Q V E -- E LPY YHPGEGSP E VR YL L ARR Q ALGGYLP A R RTFA E H L T VP A L EF F G 478
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 483 A Q LK S SGERE F STTMAFVRIL ST LLKDK K IGKR V VPIVPDE S RTFGMEG M FRQ Y GI WN P K GQ Q YTP Q D K D Q L MF YKES V D 562
Cdd:TIGR00759 479 A L LK G SGERE V STTMAFVRIL NK LLKDK E IGKR I VPIVPDE A RTFGMEG L FRQ I GI YS P H GQ T YTP V D A D S L LA YKES K D 558
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 563 GQILQEGINE P GAMA D WIAAATSYA NSDFA MIPFYIYYSMFGFQRIGDL A WAA G D MH ARGFLLG G TAGRTTLNGEGLQHE 642
Cdd:TIGR00759 559 GQILQEGINE A GAMA S WIAAATSYA THGEP MIPFYIYYSMFGFQRIGDL C WAA A D QR ARGFLLG A TAGRTTLNGEGLQHE 638
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 643 DGHS HI QA DL IPNC VS YDP T F Q YEVAVI VQ DGLRRMY ANN EDVFYY I T L MNENY TH P D MPEGAE QD ILKG M Y LLKA -- GG 720
Cdd:TIGR00759 639 DGHS LL QA AT IPNC IA YDP A F A YEVAVI ME DGLRRMY GEQ EDVFYY V T V MNENY VQ P P MPEGAE EG ILKG L Y RFET st EE 718
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 721 K GDKK VQL M GSG T I LQE V VTG A E LL K AD F GV EA D I WS CP SF NL L H RD AVE VER F N R LHP L E AEK V PF V TSK L QGH D G PVI 800
Cdd:TIGR00759 719 K AKGH VQL L GSG A I MRA V IEA A Q LL A AD W GV AS D V WS VT SF TE L A RD GHD VER W N L LHP T E TPR V SY V AQV L NEA D A PVI 798
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 801 A A TDY I R SY A DR IR A Y I P ND Y HV LGTDGFGRSD S R A NLR R FFEVD RYN V AV AAL S ALA EQ G KVSKET V QQ AI E KYGI KA D 880
Cdd:TIGR00759 799 A S TDY V R AF A EQ IR P Y V P RK Y VT LGTDGFGRSD T R E NLR H FFEVD AKS V VL AAL Y ALA DD G EIDGDV V AD AI A KYGI DP D 878
....*..
gi 488158357 881 S A PSWK R 887
Cdd:TIGR00759 879 K A NPVY R 885
TPP_E1_EcPDC_like
cd02017 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; ...
74-461
0e+00
Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative decarboxylation of pyruvate and the subsequent acetylation of coenzyme A to acetyl-CoA. The E1 component of PDC catalyzes the first step of the multistep process, using TPP and a divalent cation as cofactors. E. coli PDC is a homodimeric enzyme.
Pssm-ID: 238975 [Multi-domain]
Cd Length: 386
Bit Score: 733.72
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 74 QN IE H RIR AFV RWNA A A I V L RA G KKDL EL GGHIA S F Q SAAT M YEVGFNHF WK A K GEG EE GDLV F FQGH VA PGIYARAF V E 153
Cdd:cd02017 1 LE IE R RIR SLI RWNA M A M V H RA N KKDL GI GGHIA T F A SAAT L YEVGFNHF FR A R GEG GG GDLV Y FQGH AS PGIYARAF L E 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 154 GRLTE D QL N NFRQEV D G H GL P SYPHP H L L PDFW Q FPTVSMGLGPI M AIYQARF LK YLE S RGL AK T KGR KVW C F C GDGEMD 233
Cdd:cd02017 81 GRLTE E QL D NFRQEV G G G GL S SYPHP W L M PDFW E FPTVSMGLGPI Q AIYQARF NR YLE D RGL KD T SDQ KVW A F L GDGEMD 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 234 EPES Q GAI A LAARE G LDNLIFV I NCNLQRLDGPVRGNGKIIQELEG N F A GAGWNV V KVIWG RR WD R LLAKD KD G I LRQRM 313
Cdd:cd02017 161 EPES L GAI G LAARE K LDNLIFV V NCNLQRLDGPVRGNGKIIQELEG I F R GAGWNV I KVIWG SK WD E LLAKD GG G A LRQRM 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 314 EE CL DGDYQT Y K S KDGAYVREHFF N - T PELKALV A D MT DE Q LWALNRGGHDP Q KVY N AY DR A AN H a D GKPTVILAKTIKG 392
Cdd:cd02017 241 EE TV DGDYQT L K A KDGAYVREHFF G k Y PELKALV T D LS DE D LWALNRGGHDP R KVY A AY KK A VE H - K GKPTVILAKTIKG 319
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488158357 393 YG M GA S GEG Q N V AHQ A KKM DKAS LK QF RDRF D IPV T DEQ I E S G dl PY LTFAPDT EE Y KYLH A RR D ALGG 461
Cdd:cd02017 320 YG L GA A GEG R N H AHQ V KKM TEDE LK AL RDRF G IPV S DEQ L E E G -- PY YKPPEGS EE I KYLH E RR H ALGG 386
PDH_E1_M
pfam17831 Pyruvate dehydrogenase E1 component middle domain; This entry represents one of the thiamin ...
473-699
7.10e-120
Pyruvate dehydrogenase E1 component middle domain; This entry represents one of the thiamin diphosphate-binding domains found in pyruvate dehydrogenase E1 component.
Pssm-ID: 465525 [Multi-domain]
Cd Length: 229
Bit Score: 362.90
E-value: 7.10e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 473 LE V P E L -- SA F DA Q LKS S GE RE F STTMAFVRIL ST L L KDKKIGK R VVPI V PDE S RTFGMEGMFRQ Y GI WNPK GQ Q Y T P Q D 550
Cdd:pfam17831 1 LE I P D L dd KI F AS Q TGG S KG RE I STTMAFVRIL NG L V KDKKIGK Q VVPI I PDE A RTFGMEGMFRQ L GI YTSE GQ K Y E P V D 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 551 K D Q L MFY K E SVD GQIL Q EGI N E P GAM AD WIAAATSY A N SDFAMI PFY I YYSMFGFQRIGDLAWAAGDM H ARGFL L GGTAG 630
Cdd:pfam17831 81 K G Q I MFY R E DKQ GQIL E EGI S E A GAM SA WIAAATSY S N HNTTLL PFY V YYSMFGFQRIGDLAWAAGDM Q ARGFL V GGTAG 160
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488158357 631 RTTLNGEGLQH E DGHSHIQA DL IPNC V SYDPT FQY EVAVIVQDGL R RM Y A NN E DV FYY I T L MNENY T HP 699
Cdd:pfam17831 161 RTTLNGEGLQH Q DGHSHIQA ST IPNC R SYDPT YAH EVAVIVQDGL K RM F A DK E NC FYY L T V MNENY E HP 229
Name
Accession
Description
Interval
E-value
AceE
COG2609 Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion] ...
2-887
0e+00
Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion]; Pyruvate dehydrogenase complex, dehydrogenase (E1) component is part of the Pathway/BioSystem: Pyruvate oxidation
Pssm-ID: 442021 [Multi-domain]
Cd Length: 891
Bit Score: 1885.17
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 2 ST QL H D V DP I ETQEWL DA L SS V L E Y EG G ERA Q YLLE N L VKYC R DK GV RM P HGT TTPY L NT VS VE N E KGI PGD QNI E H RIR 81
Cdd:COG2609 7 PS QL P D I DP Q ETQEWL ES L DA V I E E EG P ERA R YLLE R L LERA R RS GV GL P FSA TTPY I NT IP VE Q E PPY PGD EEL E R RIR 86
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 82 AFV RWNA A A I V L RA GK K DLE LGGHI A SF Q SAAT M YEVGFNHF WKAKGEGEE GDLV F FQGH VA PGIYARAF V EGRLTE D QL 161
Cdd:COG2609 87 SII RWNA M A M V V RA NR K GGG LGGHI S SF A SAAT L YEVGFNHF FRGPDHPGG GDLV Y FQGH AS PGIYARAF L EGRLTE E QL 166
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 162 N NFRQEVDG H GL P SYPHP H L L PDFWQFPTVSMGLGPI M AIYQARF L KYL ES RGL AK T KG RKVW C F C GDGEMDEPES Q GAI 241
Cdd:COG2609 167 D NFRQEVDG K GL S SYPHP W L M PDFWQFPTVSMGLGPI N AIYQARF M KYL HN RGL KD T SD RKVW A F L GDGEMDEPES L GAI 246
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 242 A LAARE G LDNLIFVINCNLQRLDGPVRGNGKIIQELEG N F A GAGWNV V KVIWG RR WD R LLAKD K DG I L RQ RM E E CL DGDY 321
Cdd:COG2609 247 S LAARE K LDNLIFVINCNLQRLDGPVRGNGKIIQELEG V F R GAGWNV I KVIWG SE WD P LLAKD T DG A L VK RM N E TV DGDY 326
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 322 QTYK S KDGAYVREHFF NT - PELKALVADM T DE QL W A LNRGGHDP Q KVY N AY DR A AN H a D G K PTVILAKTIKGYGMG AS GE 400
Cdd:COG2609 327 QTYK A KDGAYVREHFF GK y PELKALVADM S DE DI W R LNRGGHDP R KVY A AY KA A VE H - K G Q PTVILAKTIKGYGMG EA GE 405
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 401 G Q N VA HQ A KK M D KAS LK Q FRDRF D IP VT DEQ I E sg D LPY LTF A P D TE E Y KYLH A RR D ALGGYLPQR KPTQ E V LEVPELSA 480
Cdd:COG2609 406 G R N IT HQ Q KK L D LDD LK A FRDRF N IP IS DEQ L E -- E LPY YKP A E D SP E M KYLH E RR K ALGGYLPQR RTKA E P LEVPELSA 483
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 481 F D A Q LK S SG E RE F STTMAFVRIL ST LLKDK K IGKR V VPIVPDE S RTFGMEG M FRQ Y GI WN P K GQ Q YTP Q D K DQL MF YKES 560
Cdd:COG2609 484 F A A L LK G SG K RE I STTMAFVRIL ND LLKDK E IGKR I VPIVPDE A RTFGMEG L FRQ I GI YS P V GQ L YTP V D A DQL LY YKES 563
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 561 V DGQILQEGINE P GAM AD WIAA A TSY ANSDFA MIPFYIYYSMFGFQR I GDLAWAAGD MH ARGFL L G G TAGRTTLNGEGLQ 640
Cdd:COG2609 564 K DGQILQEGINE A GAM SS WIAA G TSY STHGVP MIPFYIYYSMFGFQR V GDLAWAAGD QR ARGFL I G A TAGRTTLNGEGLQ 643
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 641 H E DGHSH IQ A DL IPNCVSYDP T F Q YE V AVIVQDGLRRMY ANN E D VFYYIT L MNENY TH P D MPEG A E QD ILKGMYLLK A G G 720
Cdd:COG2609 644 H Q DGHSH LL A ST IPNCVSYDP A F A YE L AVIVQDGLRRMY GEQ E N VFYYIT V MNENY AQ P A MPEG V E EG ILKGMYLLK E G E 723
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 721 KGD K - K VQL M GSGTIL Q EV VTG AELL KA D F GV E AD I WS CP SFN L L H RD AVE VER F N R LHP L E AEK VP F VT SK L Q G HD GPV 799
Cdd:COG2609 724 GKG K p R VQL L GSGTIL R EV LAA AELL AE D W GV A AD V WS VT SFN E L R RD GLD VER W N L LHP E E EPR VP Y VT QC L A G AE GPV 803
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 800 I AATDY I R SYA D R IR AYI P ND Y H VLGTDGFGRSD S R AN LRRFFEVDRY NVA VAAL S ALA EQ GK VSKET V QQ AI E KYGI KA 879
Cdd:COG2609 804 V AATDY M R AVP D Q IR PWV P GR Y T VLGTDGFGRSD T R EA LRRFFEVDRY SIV VAAL K ALA DE GK IDASV V AE AI K KYGI DP 883
....*...
gi 488158357 880 D SAPSWKR 887
Cdd:COG2609 884 D KPNPLTA 891
aceE
PRK09405 pyruvate dehydrogenase subunit E1; Reviewed
1-885
0e+00
pyruvate dehydrogenase subunit E1; Reviewed
Pssm-ID: 236500 [Multi-domain]
Cd Length: 891
Bit Score: 1857.88
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 1 MST QL H D V DPIETQEWL D AL S SV LEY EG G ERA Q YLLE N L VKYC R D KGV RM P HGT TTPY L NT VS VE N E KGI PGD QNI E H RI 80
Cdd:PRK09405 5 SES QL N D I DPIETQEWL E AL D SV IRE EG P ERA H YLLE Q L LERA R E KGV SL P ASA TTPY I NT IP VE E E PEY PGD LEL E R RI 84
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 81 R AFV RWNAAA I VLRA G KKDL E LGGHI A SF Q S A AT M YEVGFNHF WK A KG E GEE GDLVFFQGH VA PGIYARAF V EGRLTE D Q 160
Cdd:PRK09405 85 R SYI RWNAAA M VLRA N KKDL G LGGHI S SF A S S AT L YEVGFNHF FR A PN E PHG GDLVFFQGH AS PGIYARAF L EGRLTE E Q 164
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 161 L N NFRQEVDG H GL P SYPHP H L L PDFWQFPTVSMGLGPIMAIYQARFLKYLE S RGL AK T KGR KVW C F C GDGEMDEPES Q GA 240
Cdd:PRK09405 165 L D NFRQEVDG K GL S SYPHP W L M PDFWQFPTVSMGLGPIMAIYQARFLKYLE N RGL KD T SDQ KVW A F L GDGEMDEPES L GA 244
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 241 I A LAARE G LDNLIFVINCNLQRLDGPVRGNGKIIQELEG N F A GAGWNV V KVIWG R RWD R LLAKD KD G I L R Q R M E E CL DGD 320
Cdd:PRK09405 245 I S LAARE K LDNLIFVINCNLQRLDGPVRGNGKIIQELEG I F R GAGWNV I KVIWG S RWD P LLAKD TS G K L V Q L M N E TV DGD 324
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 321 YQTYK S KDGAYVREHFF - NT PE L KALVADM T D EQL WALNRGGHDP Q KVY N AY DR A AN H A d G K PTVILAKTIKGYGMG AS G 399
Cdd:PRK09405 325 YQTYK A KDGAYVREHFF g KY PE T KALVADM S D DDI WALNRGGHDP R KVY A AY KA A VE H K - G Q PTVILAKTIKGYGMG EA G 403
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 400 EG Q N V AHQ A KK M D KAS LK Q FRDRF D IP VT DEQ I E sg D LPY LTFAP D TE E Y KYLH A RR D ALGGYLP Q R K P TQ E V LEVP E LS 479
Cdd:PRK09405 404 EG K N I AHQ V KK L D LDD LK H FRDRF N IP IS DEQ L E -- K LPY YKPGE D SP E I KYLH E RR K ALGGYLP A R R P KF E P LEVP A LS 481
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 480 AF D A Q LK S SGERE F STTMAFVRIL ST LLKDK K IGKR V VPI V PDE S RTFGMEG M FRQ Y GI W NP K GQ Q YTP Q D K DQLM F YKE 559
Cdd:PRK09405 482 AF E A L LK G SGERE I STTMAFVRIL NI LLKDK E IGKR I VPI I PDE A RTFGMEG L FRQ I GI Y NP H GQ L YTP V D R DQLM Y YKE 561
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 560 S V DGQILQEGINE P GAMA D WIAAATSY ANSDFA MIPFYIYYSMFGFQRIGDLAWAAGD MH ARGFLLGGTAGRTTLNGEGL 639
Cdd:PRK09405 562 S K DGQILQEGINE A GAMA S WIAAATSY STHGEP MIPFYIYYSMFGFQRIGDLAWAAGD QR ARGFLLGGTAGRTTLNGEGL 641
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 640 QHEDGHSHI Q A DL IPNCVSYDP T F Q YEVAVIVQDGLRRMY ANN E D VFYYIT L MNENY TH P D MPEGAE QD ILKGMY L L K -- 717
Cdd:PRK09405 642 QHEDGHSHI L A ST IPNCVSYDP A F A YEVAVIVQDGLRRMY GEQ E N VFYYIT V MNENY HQ P A MPEGAE EG ILKGMY K L E ta 721
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 718 A G G KG DK KVQL M GSGTIL Q EV VTG AE L L KA D F GV E AD I WS CP SFN L L H RD AVE VER F N R LHP L E AEK VP F VT SK L Q G HD G 797
Cdd:PRK09405 722 E G K KG KP KVQL L GSGTIL R EV LEA AE I L AE D Y GV A AD V WS VT SFN E L A RD GQD VER W N M LHP T E EPR VP Y VT QV L K G AE G 801
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 798 PV I AATDY IRSY A DR IRA YI P N DY H VLGTDGFGRSD S R AN LRRFFEVD RYN V A VAAL S ALA EQ G KVSKET V QQ AI E KYGI 877
Cdd:PRK09405 802 PV V AATDY MKLF A EQ IRA FV P G DY V VLGTDGFGRSD T R EA LRRFFEVD AEY V V VAAL K ALA DE G EIDASV V AE AI K KYGI 881
....*...
gi 488158357 878 KA D S A PSW 885
Cdd:PRK09405 882 DP D K A NPR 889
PRK13012
PRK13012 2-oxoacid dehydrogenase subunit E1; Provisional
4-887
0e+00
2-oxoacid dehydrogenase subunit E1; Provisional
Pssm-ID: 237267 [Multi-domain]
Cd Length: 896
Bit Score: 1568.00
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 4 QL H D V DP I ET Q EWL D AL SS V LEYE G G ERA Q YLL EN L VKYCRDK G VRM P HGT TTPY L NT VS V ENEKGI PGD QNI E H R IR A F 83
Cdd:PRK13012 16 QL P D I DP Q ET A EWL E AL DA V VAHA G P ERA R YLL DR L LERAAAR G IAL P GLL TTPY V NT IP V DQQPPY PGD LAL E E R LA A I 95
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 84 V RWNA A A I V L RA GKKDL ELGGHIAS FQ SAA TMY EVGFNHF WKAKGEGEE GDLV F FQ G H V APGIYARAF V EGRL T E D QL NN 163
Cdd:PRK13012 96 I RWNA L A M V V RA NRAYG ELGGHIAS YA SAA DLF EVGFNHF FRGRDDAGG GDLV Y FQ P H S APGIYARAF L EGRL S E E QL DH 175
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 164 FRQE VD G H GL P SYPHP H L L PDFWQFPT V SMG L GPI M AIYQARF LK YL ES RGL AK T K GRKVW C F C GDGEMDEPES QG A IA L 243
Cdd:PRK13012 176 FRQE IG G P GL S SYPHP W L M PDFWQFPT G SMG I GPI N AIYQARF MR YL QH RGL KD T S GRKVW G F F GDGEMDEPES IA A LS L 255
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 244 AAREGLDNL I FVINCNLQRLDGPVRGNG K IIQELE GN F A GAGWNV V KV I WG RR WD R L L A K D KD G I L RQ R ME E CL DG DY QT 323
Cdd:PRK13012 256 AAREGLDNL V FVINCNLQRLDGPVRGNG R IIQELE AL F R GAGWNV I KV L WG SD WD A L F A R D TT G A L VR R FA E TV DG QF QT 335
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 324 Y K SK DGAY V REHFF N - T PEL K ALVA DMT DE QLWA L N RGGHDP Q KVY N AY DR A AN H a D G K PTVILAKT I KGYGMG AS GEG Q 402
Cdd:PRK13012 336 F K AN DGAY N REHFF G q D PEL A ALVA HLS DE DIDR L K RGGHDP R KVY A AY AA A VR H - K G Q PTVILAKT K KGYGMG EA GEG R 414
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 403 NVA HQ A KK M D KAS LK Q FRDRF DI P VT DEQ I E S gd LP YLTF A P D TE E YK YLHARR D ALGGYLP Q R KPTQEV L E VP E LSAF D 482
Cdd:PRK13012 415 MTT HQ Q KK L D VEA LK A FRDRF RL P LS DEQ L E Q -- LP FYKP A E D SP E MR YLHARR A ALGGYLP R R RTAAPP L P VP P LSAF A 492
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 483 AQLKSS G ER E F STTMAFVR I L ST LLKDK KI G K R V VPIV P DE S RTFGM EGM FRQ Y GI WN P K GQ Q Y T P Q D KDQ L MF Y K E SV D 562
Cdd:PRK13012 493 QFALGA G GK E M STTMAFVR M L GN LLKDK AL G P R I VPIV A DE A RTFGM ANL FRQ V GI YS P L GQ L Y E P E D AGS L LY Y R E AK D 572
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 563 GQIL Q EGI N E P GA MAD WIAAATSY ANSDFA M I PFYIYYSMFGFQR I GDL A WAA G D MH ARGFLLG G TAGRTTL N GEGLQH E 642
Cdd:PRK13012 573 GQIL E EGI T E A GA ISS WIAAATSY SVHGLP M L PFYIYYSMFGFQR V GDL I WAA A D QR ARGFLLG A TAGRTTL G GEGLQH Q 652
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 643 DGHSH IQ A DL IPNC VS YDP T F Q YE V AVIV Q DG L RRM YANN EDVFYY I T L MNENY TH P DM PEGAE QD ILKGMY L L K A GGKG 722
Cdd:PRK13012 653 DGHSH LL A ST IPNC RA YDP A F A YE L AVIV D DG M RRM LEEQ EDVFYY L T V MNENY AQ P AL PEGAE EG ILKGMY R L A A AAEA 732
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 723 d KK VQL M GSG T IL Q EV VTG A E LL KA D F GV E AD I WS CP SF NL L H RD AVEV ER F N R L H P L E AEK VP F VT SK L Q G HD GPV I AA 802
Cdd:PRK13012 733 - PR VQL L GSG A IL R EV LAA A R LL AD D W GV D AD V WS VT SF TE L R RD GLAA ER A N L L G P A E EAR VP Y VT QC L A G TR GPV V AA 811
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 803 TDY I R SYADR IRA YI P ND Y HV LGTDGFGRSD S RA N LRRFFEVDR YNVAV AAL S ALA EQ G K V SKET V QQ AIE K YGI KA D SA 882
Cdd:PRK13012 812 TDY V R AVPEQ IRA FV P AR Y VT LGTDGFGRSD T RA A LRRFFEVDR HSIVL AAL K ALA DD G E V ERTV V AE AIE R YGI DD D KT 891
....*
gi 488158357 883 P S W KR 887
Cdd:PRK13012 892 P P W EV 896
aceE
TIGR00759 pyruvate dehydrogenase E1 component, homodimeric type; Most members of this family are ...
4-887
0e+00
pyruvate dehydrogenase E1 component, homodimeric type; Most members of this family are pyruvate dehydrogenase complex, E1 component. Note: this family was classified as subfamily rather than equivalog because it includes a counterexample from Pseudomonas putida, MdeB, that is active as an E1 component of an alpha-ketoglutarate dehydrogenase complex rather than a pyruvate dehydrogase complex. The second pyruvate dehydrogenase complex E1 protein from Alcaligenes eutrophus, PdhE, complements an aceE mutant of E. coli but is not part of a pyruvate dehydrogenase complex operon, is more similar to the Pseudomonas putida MdeB than to E. coli AceE, and may have also have a different primary specificity.
Pssm-ID: 273255 [Multi-domain]
Cd Length: 885
Bit Score: 1473.46
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 4 Q LH DVDPIETQEWL DA L S SVL EY EG GE RA Q YLLE N L VK Y C R DK GV RM P H GTTT P Y L NT VS VE NEKGI PGD QNI E H RIR AF 83
Cdd:TIGR00759 2 Q PN DVDPIETQEWL ES L D SVL AE EG PA RA R YLLE Q L LE Y A R EH GV PI P A GTTT D Y I NT IP VE EQPAY PGD LEL E R RIR SI 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 84 V RWNA A A I VLRA G KKDL E LGGHI ASFQ SAAT M YEVGFNHF WKAKG EG EE GDLVFFQGH V APGIYARAF V EGRLTE D QL N N 163
Cdd:TIGR00759 82 I RWNA I A M VLRA N KKDL G LGGHI STYA SAAT L YEVGFNHF FRGHS EG GG GDLVFFQGH A APGIYARAF L EGRLTE E QL D N 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 164 FRQEV D G H GL P SYPHP H L L PDFWQFPTVSMGLGPI M AIYQARF L KYLE S RGL AK T KGR KVW C F C GDGEMDEPES Q GAI AL 243
Cdd:TIGR00759 162 FRQEV Q G D GL S SYPHP W L M PDFWQFPTVSMGLGPI N AIYQARF M KYLE N RGL KD T GDQ KVW A F L GDGEMDEPES K GAI TF 241
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 244 AARE G LDNL I FVINCNLQRLDGPVRGNGKIIQELE GN F A GAGWNV V KV I WG RR WD R LLA K D KD G I L RQR M E E CL DGDYQT 323
Cdd:TIGR00759 242 AARE K LDNL T FVINCNLQRLDGPVRGNGKIIQELE SL F R GAGWNV I KV L WG SE WD A LLA R D TS G V L VKL M N E TV DGDYQT 321
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 324 YK S KDGAYVREHFFN - TPELKALVADM T D EQL WALNRGGHDP Q KVY N AY DR A AN H A d G K PTVILAKTIKGYGMG ASG E GQ 402
Cdd:TIGR00759 322 YK A KDGAYVREHFFN r TPELKALVADM S D ADI WALNRGGHDP R KVY A AY AA A QE H K - G Q PTVILAKTIKGYGMG DAA E SR 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 403 N V AHQ A KK MDKAS LK Q FRDRF DI P VT D E Q I E sg D LPY LTFAPDTE E YK YL H ARR D ALGGYLP Q R KPTQ E V L E VP E L SA F D 482
Cdd:TIGR00759 401 N T AHQ V KK LEVDA LK N FRDRF EL P LS D A Q V E -- E LPY YHPGEGSP E VR YL L ARR Q ALGGYLP A R RTFA E H L T VP A L EF F G 478
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 483 A Q LK S SGERE F STTMAFVRIL ST LLKDK K IGKR V VPIVPDE S RTFGMEG M FRQ Y GI WN P K GQ Q YTP Q D K D Q L MF YKES V D 562
Cdd:TIGR00759 479 A L LK G SGERE V STTMAFVRIL NK LLKDK E IGKR I VPIVPDE A RTFGMEG L FRQ I GI YS P H GQ T YTP V D A D S L LA YKES K D 558
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 563 GQILQEGINE P GAMA D WIAAATSYA NSDFA MIPFYIYYSMFGFQRIGDL A WAA G D MH ARGFLLG G TAGRTTLNGEGLQHE 642
Cdd:TIGR00759 559 GQILQEGINE A GAMA S WIAAATSYA THGEP MIPFYIYYSMFGFQRIGDL C WAA A D QR ARGFLLG A TAGRTTLNGEGLQHE 638
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 643 DGHS HI QA DL IPNC VS YDP T F Q YEVAVI VQ DGLRRMY ANN EDVFYY I T L MNENY TH P D MPEGAE QD ILKG M Y LLKA -- GG 720
Cdd:TIGR00759 639 DGHS LL QA AT IPNC IA YDP A F A YEVAVI ME DGLRRMY GEQ EDVFYY V T V MNENY VQ P P MPEGAE EG ILKG L Y RFET st EE 718
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 721 K GDKK VQL M GSG T I LQE V VTG A E LL K AD F GV EA D I WS CP SF NL L H RD AVE VER F N R LHP L E AEK V PF V TSK L QGH D G PVI 800
Cdd:TIGR00759 719 K AKGH VQL L GSG A I MRA V IEA A Q LL A AD W GV AS D V WS VT SF TE L A RD GHD VER W N L LHP T E TPR V SY V AQV L NEA D A PVI 798
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 801 A A TDY I R SY A DR IR A Y I P ND Y HV LGTDGFGRSD S R A NLR R FFEVD RYN V AV AAL S ALA EQ G KVSKET V QQ AI E KYGI KA D 880
Cdd:TIGR00759 799 A S TDY V R AF A EQ IR P Y V P RK Y VT LGTDGFGRSD T R E NLR H FFEVD AKS V VL AAL Y ALA DD G EIDGDV V AD AI A KYGI DP D 878
....*..
gi 488158357 881 S A PSWK R 887
Cdd:TIGR00759 879 K A NPVY R 885
AKGDH_not_PDH
TIGR03186 alpha-ketoglutarate dehydrogenase; Several bacterial species have a paralog to homodimeric ...
7-887
0e+00
alpha-ketoglutarate dehydrogenase; Several bacterial species have a paralog to homodimeric form of the pyruvate dehydrogenase E1 component (see model TIGR00759), often encoded next to L-methionine gamma-lyase gene (mdeA). The member from a strain of Pseudomonas putida was shown to act on alpha-ketobutyrate, which is produced by MdeA.This model serves as an exception model to TIGR00759, as other proteins hitting TIGR00759 should be identified as the pyruvate dehydrogenase E1 component.
Pssm-ID: 132230 [Multi-domain]
Cd Length: 889
Bit Score: 1134.22
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 7 D V DP I ET Q EWLDAL SS V LEYE G G ERAQYLL EN L VKYCRDK G VRM P HGTT TPY L NT VS V EN E KGI PGD QNI E H R IR A FV RW 86
Cdd:TIGR03186 5 D T DP Q ET A EWLDAL DG V VAHA G A ERAQYLL AQ L AAHAARL G LAP P AAGA TPY V NT IA V DQ E PPY PGD LQL E E R LA A IL RW 84
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 87 NA A A I V L RA GKKDL ELGGHIAS FQ SAA TMY EVGFNHF WK A K G EGEE GDLV F FQ G H V APG I YARAF V EG R L TED QL NNF RQ 166
Cdd:TIGR03186 85 NA L A M V V RA NRAYG ELGGHIAS YA SAA DLF EVGFNHF FR A A G DASG GDLV Y FQ P H S APG V YARAF L EG F L SDA QL AHY RQ 164
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 167 E VD G H GL P SYPHP H L L PDFWQFPT V SMG L GPI M AIYQARF LK YL ES RGLA K T K GRKVW C F C GDGEMDEPES Q GA IA LAAR 246
Cdd:TIGR03186 165 E IA G P GL C SYPHP W L M PDFWQFPT G SMG I GPI N AIYQARF MR YL QN RGLA R T E GRKVW G F F GDGEMDEPES I GA LS LAAR 244
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 247 E G LDNL I FVINCNLQRLDGPVRGNG K II Q ELE GN FAGAGWNV V KV I WG RR WD R L L A K D KD G I L RQRMEECL DG DY QT YKS 326
Cdd:TIGR03186 245 E R LDNL V FVINCNLQRLDGPVRGNG R II D ELE SQ FAGAGWNV I KV L WG SD WD A L F A R D AT G A L ARAFAHTV DG QF QT FSA 324
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 327 K DGAY V R EH FF N - T P E L K ALVA DMT DE QLWA L N RGGHD PQ K V Y N AYDRA AN H a D G K PTVILAKT I KG Y GMGA S G E G QNVA 405
Cdd:TIGR03186 325 N DGAY N R AR FF G q D P A L A ALVA HLS DE DIDR L R RGGHD AR K L Y A AYDRA VR H - E G R PTVILAKT M KG F GMGA I G Q G RMTT 403
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 406 HQ A KK M D KAS L KQ FRDRF DI P VT D EQI E S gd L PYLTFAP D TE E YK YLHARR D ALGGYLP Q R KP - TQEV L E VP E L SAFDAQ 484
Cdd:TIGR03186 404 HQ Q KK L D VEA L LA FRDRF RL P LS D ADV E Q -- L KFYKPDE D SA E MR YLHARR A ALGGYLP R R RT a ATHA L A VP A L PSWGRF 481
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 485 LKSSGER E F STTMA F VR I L ST LLKD KKI G K R V VPIV P DE S RTFGM EGM FRQ Y GI WN P K GQ Q Y T P Q D KDQLMF Y K E SV DGQ 564
Cdd:TIGR03186 482 ALDAEGK E M STTMA I VR M L GA LLKD AEL G P R I VPIV A DE A RTFGM ANL FRQ V GI YS P L GQ R Y E P E D LGSMLY Y R E DT DGQ 561
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 565 IL Q EGI N E P GA MAD WIAAATSY ANS D FA M I PFYIYYSMFGFQRIGDL A WAA G D MH ARGFL L G G T A G R TTL N GEGLQH E DG 644
Cdd:TIGR03186 562 IL E EGI S E A GA ISS WIAAATSY SVH D LP M L PFYIYYSMFGFQRIGDL I WAA A D QR ARGFL I G A T S G K TTL G GEGLQH Q DG 641
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 645 H SH IQ A DLI PNC VSY DP T F Q YEVAVIV QD G L R R M YANNE D V FYY I T LM NENY TH P DM PE GAEQD ---- ILKGMY L L KAGG 720
Cdd:TIGR03186 642 T SH LA A STV PNC RAW DP A F A YEVAVIV DE G M R E M LERQR D E FYY L T VT NENY AQ P SL PE DRLDA vrrg ILKGMY P L DPAA 721
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 721 KGDKK VQL M GSG T IL Q EV VTG A E LL KA D F G VE A DI WS CP SF NL L H RD AVEV ER FN RL HPL E AEKV P F V TSK L QGHD GPVI 800
Cdd:TIGR03186 722 LAAAR VQL L GSG A IL G EV QAA A R LL RD D W G ID A AV WS VT SF TE L A RD GRAA ER AQ RL GDA E RPPS P H V AQA L GATQ GPVI 801
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 801 AATDY I R SYADR IRAY I P ND Y HV LGTDGFGRSD S RA N LR R FFEVDR YNVAV AAL S ALA EQ G K V SKET V Q QAI EK YG IK A - 879
Cdd:TIGR03186 802 AATDY V R AVPEL IRAY V P RR Y VT LGTDGFGRSD T RA A LR A FFEVDR ASIVI AAL Q ALA DD G L V ARDV V R QAI AR YG KA A t 881
....*...
gi 488158357 880 DS AP S W K R 887
Cdd:TIGR03186 882 SR AP P W E R 889
TPP_E1_EcPDC_like
cd02017 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; ...
74-461
0e+00
Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative decarboxylation of pyruvate and the subsequent acetylation of coenzyme A to acetyl-CoA. The E1 component of PDC catalyzes the first step of the multistep process, using TPP and a divalent cation as cofactors. E. coli PDC is a homodimeric enzyme.
Pssm-ID: 238975 [Multi-domain]
Cd Length: 386
Bit Score: 733.72
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 74 QN IE H RIR AFV RWNA A A I V L RA G KKDL EL GGHIA S F Q SAAT M YEVGFNHF WK A K GEG EE GDLV F FQGH VA PGIYARAF V E 153
Cdd:cd02017 1 LE IE R RIR SLI RWNA M A M V H RA N KKDL GI GGHIA T F A SAAT L YEVGFNHF FR A R GEG GG GDLV Y FQGH AS PGIYARAF L E 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 154 GRLTE D QL N NFRQEV D G H GL P SYPHP H L L PDFW Q FPTVSMGLGPI M AIYQARF LK YLE S RGL AK T KGR KVW C F C GDGEMD 233
Cdd:cd02017 81 GRLTE E QL D NFRQEV G G G GL S SYPHP W L M PDFW E FPTVSMGLGPI Q AIYQARF NR YLE D RGL KD T SDQ KVW A F L GDGEMD 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 234 EPES Q GAI A LAARE G LDNLIFV I NCNLQRLDGPVRGNGKIIQELEG N F A GAGWNV V KVIWG RR WD R LLAKD KD G I LRQRM 313
Cdd:cd02017 161 EPES L GAI G LAARE K LDNLIFV V NCNLQRLDGPVRGNGKIIQELEG I F R GAGWNV I KVIWG SK WD E LLAKD GG G A LRQRM 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 314 EE CL DGDYQT Y K S KDGAYVREHFF N - T PELKALV A D MT DE Q LWALNRGGHDP Q KVY N AY DR A AN H a D GKPTVILAKTIKG 392
Cdd:cd02017 241 EE TV DGDYQT L K A KDGAYVREHFF G k Y PELKALV T D LS DE D LWALNRGGHDP R KVY A AY KK A VE H - K GKPTVILAKTIKG 319
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488158357 393 YG M GA S GEG Q N V AHQ A KKM DKAS LK QF RDRF D IPV T DEQ I E S G dl PY LTFAPDT EE Y KYLH A RR D ALGG 461
Cdd:cd02017 320 YG L GA A GEG R N H AHQ V KKM TEDE LK AL RDRF G IPV S DEQ L E E G -- PY YKPPEGS EE I KYLH E RR H ALGG 386
PDH_E1_M
pfam17831 Pyruvate dehydrogenase E1 component middle domain; This entry represents one of the thiamin ...
473-699
7.10e-120
Pyruvate dehydrogenase E1 component middle domain; This entry represents one of the thiamin diphosphate-binding domains found in pyruvate dehydrogenase E1 component.
Pssm-ID: 465525 [Multi-domain]
Cd Length: 229
Bit Score: 362.90
E-value: 7.10e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 473 LE V P E L -- SA F DA Q LKS S GE RE F STTMAFVRIL ST L L KDKKIGK R VVPI V PDE S RTFGMEGMFRQ Y GI WNPK GQ Q Y T P Q D 550
Cdd:pfam17831 1 LE I P D L dd KI F AS Q TGG S KG RE I STTMAFVRIL NG L V KDKKIGK Q VVPI I PDE A RTFGMEGMFRQ L GI YTSE GQ K Y E P V D 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 551 K D Q L MFY K E SVD GQIL Q EGI N E P GAM AD WIAAATSY A N SDFAMI PFY I YYSMFGFQRIGDLAWAAGDM H ARGFL L GGTAG 630
Cdd:pfam17831 81 K G Q I MFY R E DKQ GQIL E EGI S E A GAM SA WIAAATSY S N HNTTLL PFY V YYSMFGFQRIGDLAWAAGDM Q ARGFL V GGTAG 160
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488158357 631 RTTLNGEGLQH E DGHSHIQA DL IPNC V SYDPT FQY EVAVIVQDGL R RM Y A NN E DV FYY I T L MNENY T HP 699
Cdd:pfam17831 161 RTTLNGEGLQH Q DGHSHIQA ST IPNC R SYDPT YAH EVAVIVQDGL K RM F A DK E NC FYY L T V MNENY E HP 229
TPP_TK
cd02012 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK ...
84-394
6.67e-24
Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the pentose phosphate pathway and provides precursors for nucleotide, aromatic amino acid and vitamin biosynthesis. In addition, the enzyme plays a central role in the Calvin cycle in plants. Typically, TKs are homodimers. They require TPP and divalent cations, such as magnesium ions, for activity.
Pssm-ID: 238970 [Multi-domain]
Cd Length: 255
Bit Score: 101.81
E-value: 6.67e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 84 V R WNAAAI V LR AG kkdlel G GH IASFQ SAA TMYE V GFNHF -- WKAKGEGEEGDLV F FQ -- GH VA P GI YA RAFVE G R L T E D 159
Cdd:cd02012 3 I R RLSIDM V QK AG ------ S GH PGGSL SAA DILA V LYFKV lk YDPADPKWPNRDR F VL sk GH AS P AL YA VLALA G Y L P E E 76
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 160 Q L NN FRQ ev D G HG LP SY P HPH L l PDFWQFP T ------ V S MGL G pi MA IYQ arfl K Y L ESRG laktkgr K V WCFC GDGE MD 233
Cdd:cd02012 77 D L KT FRQ -- L G SR LP GH P EYG L - TPGVEVT T gslgqg L S VAV G -- MA LAE ---- K L L GFDY ------- R V YVLL GDGE LQ 140
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 234 E PESQG A IAL A AREG LDNLI FVINC N LQRL DGP VR g NGKIIQE L EGN F AGA GWNV VK V I wgrrwdrllakdkdgilrqrm 313
Cdd:cd02012 141 E GSVWE A ASF A GHYK LDNLI AIVDS N RIQI DGP TD - DILFTED L AKK F EAF GWNV IE V D --------------------- 198
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 314 eecldgdyqtykskdgayvrehffntpelkalvadmtdeqlwalnrg GHD PQKVYN A YDR A ANHAD g KPT V I L AKTIKG Y 393
Cdd:cd02012 199 ----------------------------------------------- GHD VEEILA A LEE A KKSKG - KPT L I I AKTIKG K 230
.
gi 488158357 394 G 394
Cdd:cd02012 231 G 231
PRK05899
PRK05899 transketolase; Reviewed
104-832
7.92e-24
transketolase; Reviewed
Pssm-ID: 235639 [Multi-domain]
Cd Length: 586
Bit Score: 107.14
E-value: 7.92e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 104 GH IASFQS AA TMYE V GFNH F --------- W KAK gegeeg D - L V FFQ GH VAPGI Y ARAFVE G - R L TE D Q L N NFRQ ev D G HG 172
Cdd:PRK05899 29 GH PGMPMG AA DIAY V LWTR F lrhdpknpk W PNR ------ D r F V LSA GH GSMLL Y SLLHLA G y D L SI D D L K NFRQ -- L G SK 100
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 173 L P SY P HPHLL P df W --------- Q fp TVSMGL G pi MA I y QARF L KY L ES R GLAKTKGRKVWCF CGDG EMD E PE S QG A IA L 243
Cdd:PRK05899 101 T P GH P EYGHT P -- G vetttgplg Q -- GLANAV G -- MA L - AEKY L AA L FN R PGLDIVDHYTYVL CGDG DLM E GI S HE A CS L 173
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 244 A AREG L D NLI FVINC N - LQ r L DGP VR gn G KIIQELEGN F AGA GW N V VK V iwgrrw D rllakdkdgilrqrmeecldgdyq 322
Cdd:PRK05899 174 A GHLK L G NLI VIYDD N r IS - I DGP TE -- G WFTEDVKKR F EAY GW H V IE V ------ D ------------------------ 220
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 323 tykskdgayvrehffntpelkalvadmtdeqlwalnrg GHD PQKVYN A YDR A an H A DG KPT V I L AKTI K G Y gm GA SG - EG 401
Cdd:PRK05899 221 -------------------------------------- GHD VEAIDA A IEE A -- K A ST KPT L I I AKTI I G K -- GA PN k EG 258
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 402 QNVA H Q A kkmdkaslkqfrdrfdi P VTD E Q I E sgdlpyltfapdteeykylh A RRDA LG G yl PQ RK PTQEV L EV ----- P 476
Cdd:PRK05899 259 THKV H G A ----------------- P LGA E E I A -------------------- A AKKE LG W -- DY RK ASGKA L NA lakal P 299
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 477 EL SAFD A Q L KS S gerefst TM afvrils T LL K DK K I gkrvvpivpdesrtfgmegmfrqygiwnpkgqqytpqdkdqlm F 556
Cdd:PRK05899 300 EL VGGS A D L AG S ------- NN ------- T KI K GS K D ------------------------------------------- F 322
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 557 YK E SVD G QILQE G IN E PGAM A dw IA AATSYAN ------ SD F AM ip F YI Y ys MFGFQ R IGD L awaagd M HARGFLLG gtag 630
Cdd:PRK05899 323 AP E DYS G RYIHY G VR E FAMA A -- IA NGLALHG gfipfg GT F LV -- F SD Y -- ARNAI R LAA L ------ M KLPVIYVF ---- 386
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 631 rt T LNGE G LQ h EDG HS H i Q A -- D L ----- IPN CVSYD P TFQY E V A VIVQDG L R R MYANN ed VFY yit L MNE N YTHPD m PE 703
Cdd:PRK05899 387 -- T HDSI G VG - EDG PT H - Q P ve Q L aslra IPN LTVIR P ADAN E T A AAWKYA L E R KDGPS -- ALV --- L TRQ N LPVLE - RT 456
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 704 GA E QDIL KG M Y L L KAGG kgdk K V Q L MGS G TILQEVVTG A EL L K A D f G VEADIW S C PS FN L L hr D AVEVERFNRLH P leae 783
Cdd:PRK05899 457 AQ E EGVA KG G Y V L RDDP ---- D V I L IAT G SEVHLALEA A DE L E A E - G IKVRVV S M PS TE L F -- D EQDAAYKESVL P ---- 525
730 740 750 760
....*....|....*....|....*....|....*....|....*....
gi 488158357 784 kv PF VT SKL qghdgp VIA A tdyir SY AD RIRA Y IPN D YH VLG T D G FG R S 832
Cdd:PRK05899 526 -- AA VT ARV ------ AVE A ----- GV AD GWYK Y VGL D GK VLG I D T FG A S 561
PTZ00089
PTZ00089 transketolase; Provisional
136-423
1.01e-07
transketolase; Provisional
Pssm-ID: 173383 [Multi-domain]
Cd Length: 661
Bit Score: 55.84
E-value: 1.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 136 V FFQ GH VAPGI Y ARAFVE G R - L TEDQ L N NFRQ ev D G HGL P SY P HP H LL P DF w QFP T VSM G L G PIM A IYQ A rflky LESRG 214
Cdd:PTZ00089 63 V LSN GH ASALL Y SMLHLT G Y d L SMED L K NFRQ -- L G SRT P GH P ER H IT P GV - EVT T GPL G Q G IAN A VGL A ----- IAEKH 134
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 215 LA KTKG R -------- K V WCF CGDG EMD E PE SQ G A IA LA ARE GL DN LI FVINC N LQRL DG PV rg NGKIIQEL E GNFAGA GW 286
Cdd:PTZ00089 135 LA AKFN R pghpifdn Y V YVI CGDG CLQ E GV SQ E A LS LA GHL GL EK LI VLYDD N KITI DG NT -- DLSFTEDV E KKYEAY GW 212
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 287 N V VK V IW G R rwdrlla K D K DG i LR QRM EE C ldgdyqt Y KSK dgayvrehffntpelkalvadmtdeqlwalnrgghdpqk 366
Cdd:PTZ00089 213 H V IE V DN G N ------- T D F DG - LR KAI EE A ------- K KSK --------------------------------------- 238
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 488158357 367 vynaydraanhad GKP TV I LA KT IK GY gm G A S GE G QNVA H Q A KKM D K a SLK Q FRDR F 423
Cdd:PTZ00089 239 ------------- GKP KL I IV KT TI GY -- G S S KA G TEKV H G A PLG D E - DIA Q VKEL F 279
Transketolase_N
pfam00456 Transketolase, thiamine diphosphate binding domain; This family includes transketolase enzymes ...
76-294
1.54e-07
Transketolase, thiamine diphosphate binding domain; This family includes transketolase enzymes EC:2.2.1.1. and also partially matches to 2-oxoisovalerate dehydrogenase beta subunit EC:1.2.4.4. Both these enzymes utilize thiamine pyrophosphate as a cofactor, suggesting there may be common aspects in their mechanism of catalysis.
Pssm-ID: 395366 [Multi-domain]
Cd Length: 334
Bit Score: 54.32
E-value: 1.54e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 76 I EH R IRAFV R WN A AAI V LR A G kkdlel G GH IASFQSA A TMY EV G F NH F W K AKGEGEE ---- GDL V FFQ GH VAPGI Y ARAF 151
Cdd:pfam00456 1 I DK R AVNAI R AL A MDA V EK A N ------ S GH PGAPMGM A PIA EV L F KR F L K HNPNDPK winr DRF V LSN GH GSMLL Y SLLH 74
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 152 VE G - R L TEDQ L NN FRQ --- EVD GH glpsyphphll P D F WQFPT V SMGL GP I --------- MAI YQ arflkyles R G LA K T 218
Cdd:pfam00456 75 LT G y D L SMED L KS FRQ lgs KTP GH ----------- P E F GHTAG V EVTT GP L gqgianavg MAI AE --------- R N LA A T 134
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 219 KG R -------- KVWC F C GDG EMD E PE S QG A IA LA ARE GL D NLI FVINC N LQRL DG PVRGN gk IIQELEGN F AGA GW N V VK 290
Cdd:pfam00456 135 YN R pgfdivdh YTYV F L GDG CLM E GV S SE A SS LA GHL GL G NLI VFYDD N QISI DG ETKIS -- FTEDTAAR F EAY GW H V IE 212
....
gi 488158357 291 V IW G 294
Cdd:pfam00456 213 V ED G 216
TPP_enzymes
cd00568 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic ...
176-303
6.54e-06
Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and the branched chain alpha-keto acid dehydrogenase complexes.
Pssm-ID: 238318 [Multi-domain]
Cd Length: 168
Bit Score: 47.25
E-value: 6.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158357 176 Y P HPHLLPDFWQFPTVS MG L G PIM AI YQ A RF lkylesrglak TKG R K V W C FC GDG EMD ep ESQGAI A L A A R E GL d NL I F V 255
Cdd:cd00568 31 L P LRRGRRFLTSTGFGA MG Y G LPA AI GA A LA ----------- APD R P V V C IA GDG GFM -- MTGQEL A T A V R Y GL - PV I V V 96
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 488158357 256 INC N -------- L Q RLDGPV R GN G KIIQE -- LEGNFAGA G WNV V K V IWGRRWDRL LA K 303
Cdd:cd00568 97 VFN N ggygtirm H Q EAFYGG R VS G TDLSN pd FAALAEAY G AKG V R V EDPEDLEAA LA E 154
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
