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Conserved domains on  [gi|487987713|ref|WP_002060112|]
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MULTISPECIES: penicillin-binding protein 2 [Acinetobacter]

Protein Classification

penicillin-binding protein 2( domain architecture ID 11496821)

penicillin-binding protein (PBP) 2 is a membrane-associated enzyme that is involved in the synthesis of cross-linked peptidoglycan

EC:  3.4.16.4
Gene Ontology:  GO:0009252|GO:0008658|GO:0016020
PubMed:  18266856|18248419

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
pbp2_mrdA TIGR03423
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ...
 20-606 0e+00

penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


:

Pssm-ID: 274573 [Multi-domain]  Cd Length: 592  Bit Score: 846.81  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713   20 RIFFAVGLVIICLLVLASRYAYLQIFHYDEFSTASDKNRIRLQPLPPARGYIYDRNGVLLADNYPVFTATLSKADVENVD 99
Cdd:TIGR03423   2 RALVLGGLVLALFGVLAARLFYLQVIRGEEYATLSEDNRIRLVPIPPPRGLILDRNGVLLADNRPSFSLEIVPEKVDDLD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713  100 TVIEQLQPILELTQEDVDRFKSRIKTARKTERVAIKLNLTETNIAKFSEVKYKFPGVRIETQMTRYYPHGDLFAHVIGYV 179
Cdd:TIGR03423  82 ATLDRLAKLLDLDPEDIARFLKELKRSRRFEPIPLKSDLTEEEVARFAVNQYRLPGVEIEARLKRYYPYGELAAHVLGYV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713  180 GRINDKELKSIDKDLYAGTNLIGKIGVEKSYEDLLHGTPGYESVEADAHSNILRHLGRKDPTRGNDLYLSLDYGLQVVAS 259
Cdd:TIGR03423 162 GEINEEDLERLEPANYAGGDYIGKSGIEKYYEDELRGKPGYREVEVNARGRVIRTLSRVPPVPGKDLVLTIDARLQQAAE 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713  260 QQLAGRRGAIVAIDPRTGEILALVSSPSFNPNLFVTGINHKDYSSLRDNIDQPLYNRAVQGVYPPGSTIKPMEAMGGLHY 339
Cdd:TIGR03423 242 KALGGRRGAVVVMDPRTGEILAMVSTPSFDPNLFVDGISSKDYKALLNDPDRPLLNRAIQGVYPPGSTFKPVVALAALEE 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713  340 GIVDWATAISDPGYFHLPGdsHKFRDWKKTGHGIVNMHKAIIMSCDTYFYILANQMGIDQMNQWMRQFGFGQKTGVDLPS 419
Cdd:TIGR03423 322 GVITPETRIYCPGYFQLGG--RRFRCWKRGGHGRVDLRKAIEESCDVYFYQLALRLGIDKIAEYAKRFGFGQKTGIDLPG 399

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713  420 ESEGLYPNPEWKMRTRKSKWMKGETISVSIGQGAFTATPLQLAMATAITANHGSHVVPHVLRAT---HGAKPFTVRNAPD 496
Cdd:TIGR03423 400 EKSGLVPSREWKRKRFGQPWYPGDTLNVSIGQGYVLVTPLQLAVATAALANGGKLYKPHLVKSIedpDGGVVRRTEPEVL 479

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713  497 GKINFNgtDEDWVKMREAMIDVIQS--GTGRGIRTPL-YQIAGKTGTAQVKSIAQGKRYNEAALSERQLDHGLFVGFAPA 573
Cdd:TIGR03423 480 RPLPIS--PENLDVVREGMRDVVNGpgGTARRARLGLpYKMAGKTGTAQVVSLKQGEKYDAEQIPERLRDHALFVAFAPY 557

                         570       580       590
                  ....*....|....*....|....*....|....
gi 487987713  574 DKPEIAIAVIWENGRHGGS-AAQLAKPVFDYWLL 606
Cdd:TIGR03423 558 DNPKIAVAVIVEHGGGGSSaAAPIARKIMDAYLL 591
 
Name Accession Description Interval E-value
pbp2_mrdA TIGR03423
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ...
 20-606 0e+00

penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 274573 [Multi-domain]  Cd Length: 592  Bit Score: 846.81  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713   20 RIFFAVGLVIICLLVLASRYAYLQIFHYDEFSTASDKNRIRLQPLPPARGYIYDRNGVLLADNYPVFTATLSKADVENVD 99
Cdd:TIGR03423   2 RALVLGGLVLALFGVLAARLFYLQVIRGEEYATLSEDNRIRLVPIPPPRGLILDRNGVLLADNRPSFSLEIVPEKVDDLD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713  100 TVIEQLQPILELTQEDVDRFKSRIKTARKTERVAIKLNLTETNIAKFSEVKYKFPGVRIETQMTRYYPHGDLFAHVIGYV 179
Cdd:TIGR03423  82 ATLDRLAKLLDLDPEDIARFLKELKRSRRFEPIPLKSDLTEEEVARFAVNQYRLPGVEIEARLKRYYPYGELAAHVLGYV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713  180 GRINDKELKSIDKDLYAGTNLIGKIGVEKSYEDLLHGTPGYESVEADAHSNILRHLGRKDPTRGNDLYLSLDYGLQVVAS 259
Cdd:TIGR03423 162 GEINEEDLERLEPANYAGGDYIGKSGIEKYYEDELRGKPGYREVEVNARGRVIRTLSRVPPVPGKDLVLTIDARLQQAAE 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713  260 QQLAGRRGAIVAIDPRTGEILALVSSPSFNPNLFVTGINHKDYSSLRDNIDQPLYNRAVQGVYPPGSTIKPMEAMGGLHY 339
Cdd:TIGR03423 242 KALGGRRGAVVVMDPRTGEILAMVSTPSFDPNLFVDGISSKDYKALLNDPDRPLLNRAIQGVYPPGSTFKPVVALAALEE 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713  340 GIVDWATAISDPGYFHLPGdsHKFRDWKKTGHGIVNMHKAIIMSCDTYFYILANQMGIDQMNQWMRQFGFGQKTGVDLPS 419
Cdd:TIGR03423 322 GVITPETRIYCPGYFQLGG--RRFRCWKRGGHGRVDLRKAIEESCDVYFYQLALRLGIDKIAEYAKRFGFGQKTGIDLPG 399

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713  420 ESEGLYPNPEWKMRTRKSKWMKGETISVSIGQGAFTATPLQLAMATAITANHGSHVVPHVLRAT---HGAKPFTVRNAPD 496
Cdd:TIGR03423 400 EKSGLVPSREWKRKRFGQPWYPGDTLNVSIGQGYVLVTPLQLAVATAALANGGKLYKPHLVKSIedpDGGVVRRTEPEVL 479

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713  497 GKINFNgtDEDWVKMREAMIDVIQS--GTGRGIRTPL-YQIAGKTGTAQVKSIAQGKRYNEAALSERQLDHGLFVGFAPA 573
Cdd:TIGR03423 480 RPLPIS--PENLDVVREGMRDVVNGpgGTARRARLGLpYKMAGKTGTAQVVSLKQGEKYDAEQIPERLRDHALFVAFAPY 557

                         570       580       590
                  ....*....|....*....|....*....|....
gi 487987713  574 DKPEIAIAVIWENGRHGGS-AAQLAKPVFDYWLL 606
Cdd:TIGR03423 558 DNPKIAVAVIVEHGGGGSSaAAPIARKIMDAYLL 591
FtsI COG0768
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
 10-610 0e+00

Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440531 [Multi-domain]  Cd Length: 568  Bit Score: 644.57  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713  10 IQQEKRIYRGRIFFAVGLVIICLLVLASRYAYLQIFHYDEFSTASDKNRIRLQPLPPARGYIYDRNGVLLADNYPVFTAT 89
Cdd:COG0768    3 RKKEKRLFRRRLLLLFLLVLLLFLLLVGRLFYLQVVEGDEYAELAEENRIRTVPIPAPRGLIYDRNGNVLATNVPVYSLY 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713  90 LSKADVENVDTVIEQLQPILELTQEDVDRFKSRiktaRKTERVAIKLNLTETNIAKFSevKYKFPGVRIETQMTRYYPHG 169
Cdd:COG0768   83 ADPEEVKDPEETAEKLAKLLGLDPEELRKKLKK----KSRFPVYLKRNLSPEEAARIR--ALKLPGVYVEAEYKRYYPYG 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713 170 DLFAHVIGYVGRINdkelksidkdlyaGTNLIGKIGVEKSYEDLLHGTPGYESVEADAHSNILRHLG-RKDPTRGNDLYL 248
Cdd:COG0768  157 ELAAHVLGYVGEIN-------------GGDGIGKSGLEKAYEDLLRGTPGKRRVEVDARGRVIRDLGeEKPPVPGKDLVL 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713 249 SLDYGLQVVASQQLAG-------RRGAIVAIDPRTGEILALVSSPSFNPNLFVTGINHkdysslrdnidqPLYNRAVQGV 321
Cdd:COG0768  224 TIDSDLQKIAEEALKKaveeykaKSGAVVVMDPKTGEILAMASYPSFDPNLFVGGPDE------------PLRNRAVQGT 291

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713 322 YPPGSTIKPMEAMGGLHYGIVDWATAISDPGYFHLPGdsHKFRDWKKTGHGIVNMHKAIIMSCDTYFYILANQMGIDQMN 401
Cdd:COG0768  292 YEPGSTFKPFTAAAALEEGVITPDTTFDCPGYYRVGG--RTIRDWDRGGHGTLTLTEALAKSSNVGFYKLALRLGIDKLY 369

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713 402 QWMRQFGFGQKTGVDLPSESEGLYPNPEwkmrtrksKWMKGETISVSIGQGaFTATPLQLAMATAITANHGSHVVPHVLR 481
Cdd:COG0768  370 DYLKKFGLGQKTGIDLPGEASGLLPSPK--------RWYPGETATMSIGQG-LSVTPLQLAQAYAAIANGGVLVKPHLVK 440

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713 482 ATHGAKPFTVRNAPDGK---INfngtDEDWVKMREAMIDVIQS--GTGRGIRTPLYQIAGKTGTAQVKSIAQGKRYneaa 556
Cdd:COG0768  441 EIVDPDGEVVKEEPEVLrrvIS----PETAETVREGMEGVVNEpgGTARRAAIPGYRVAGKTGTAQVVDIGNGGYY---- 512

                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 487987713 557 lserQLDH-GLFVGFAPADKPEIAIAVIWENGRHGGSAAQLAKPVF----DYWLLTRKK 610
Cdd:COG0768  513 ----KGRHiASFVGFAPADNPRYAVAVVVENPGGGAYGGTVAAPVFreimEAYLRLLGP 567
PRK10795 PRK10795
penicillin-binding protein 2; Provisional
 1-622 0e+00

penicillin-binding protein 2; Provisional


Pssm-ID: 236761 [Multi-domain]  Cd Length: 634  Bit Score: 570.94  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713   1 MKQHFPLKDIQQEKRIYRGRIFFA-VGLVIICLLVLASRYaYLQIFHYDEFSTASDKNRIRLQPLPPARGYIYDRNGVLL 79
Cdd:PRK10795   2 KKLQNSFRDYTAESALFVRRALVAfLGILLLTGVLIANLY-NLQIVRFTDYQTRSNENRIKLVPIAPSRGIIYDRNGTPL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713  80 ADNYPVFTATLSKADVENVDTVIEQLQPILELTQEDVDRFKSRIKTARKTERVAIKLNLTETNIAKFSEVKYKFPGVRIE 159
Cdd:PRK10795  81 ALNRTIYQLEMMPEKVDNLQQTLDALRSVVDLTDDDIAAFRKERARSRRFTSIPVKTNLTEVQVARFAVNQYRFPGVEVK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713 160 TQMTRYYPHGDLFAHVIGYVGRINDKELKSIDKD----LYAGTNLIGKIGVEKSYEDLLHGTPGYESVEADAHSNILRHL 235
Cdd:PRK10795 161 GYQRRYYPYGSALTHVIGYVSKINDKDVERLDKEgklaNYAATHDIGKLGIERYYEDVLHGKTGYEEVEVNNRGRVIRQL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713 236 GRKDPTRGNDLYLSLDYGLQVVASQQLAGRRGAIVAIDPRTGEILALVSSPSFNPNLFVTGINHKDYSSLRDNIDQPLYN 315
Cdd:PRK10795 241 HEQPPQAGHDIYLTLDLKLQQYIETLLAGSRAAVVVTDPRTGGILALVSTPSYDPNLFVDGISSKDYSGLLNDPNRPLIN 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713 316 RAVQGVYPPGSTIKPMEAMGGLHYGIVDWATAISDPGYFHLPGDSHKFRDWKKTGHGIVNMHKAIIMSCDTYFYILANQM 395
Cdd:PRK10795 321 RATQGVYPPASTVKPYVAVSALSAGVITRNTSLFDPGWWQLPGSEKRYRDWKKWGHGRLNVTKSLEESADTFFYQVAYDM 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713 396 GIDQMNQWMRQFGFGQKTGVDLPSESEGLYPNPEWKMRTRKSKWMKGETISVSIGQGAFTATPLQLAMATAITANHGSHV 475
Cdd:PRK10795 401 GIDRLSEWMGKFGYGHYTGIDLAEERSGNMPTREWKQKRFKKPWYQGDTIPVGIGQGYWTATPIQMSKALMTLINDGIVK 480

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713 476 VPHVLRAT--HGAK-PFT-VRNAPDGKINfNGTdedWVKMREAMIDVIQ--SGTGRG--IRTPlYQIAGKTGTAQVKSIA 547
Cdd:PRK10795 481 VPHLLMSTaeDGKQvPWVqPHEPPVGDIH-SGY---WEIAKDGMYGVANrpNGTAHKyfASAP-YKIAAKSGTAQVFGLK 555

                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 487987713 548 QGKRYNEAALSERQLDHGLFVGFAPADKPEIAIAVIWENGRHGGSAAQLAKPVFDYWLLTRKKNPIRPANHQVNG 622
Cdd:PRK10795 556 ANETYNAHKIAERLRDHKLMTAFAPYNNPQVAVAIILENGGAGPAVGTIMRQILDHIMLGDNNTDLPAENPAVAA 630
Transpeptidase pfam00905
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss: ...
 267-602 1.53e-73

Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.


Pssm-ID: 425939 [Multi-domain]  Cd Length: 296  Bit Score: 239.24  E-value: 1.53e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713  267 GAIVAIDPRTGEILALVSSPSFNPNLFVTginhkdysslrdnidqPLYNRAVQGVYPPGSTIKPMEAMGGLHYGIVDWAT 346
Cdd:pfam00905   1 GSAVVLDPKTGEVLAMVGKPSYDPNGFIG----------------PLRNRAVTSRYEPGSTFKPFTALAALDNGVLKPDE 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713  347 AISDPGYFHLPGDShkFRDWKKTGHGIVNMHKAIIMSCDTYFYILANQMGIDQMNQWMRQFGFGQKTGVDLPSESEGLYP 426
Cdd:pfam00905  65 TIFDWPGKQQGGKS--IGDWNQDQVGIGTLRQALEYSSNWYMQKLAQKLGADKLRSYLKKFGYGNKTGIGLPGENAGYLT 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713  427 NpewkmrtrksKWMKGETISVSIGqgaFTATPLQLAMATAITANHGSHVVPHVLRATHGakpfTVRNAPDGKINFngTDE 506
Cdd:pfam00905 143 P----------YWLEGATASFGIG---LTITPLQQAQAYAAIANGGKLVPPHLVKSIED----KVDPKVLNKLPI--SKS 203

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713  507 DWVKMREAMIDVIQSGTGRGIRT-PLYQIAGKTGTAQVKSiAQGKRYNEAAlserqlDHGLFVGFAPADKPEIAIAVIWE 585
Cdd:pfam00905 204 TAEKVKDMLRLVVNDGTGTGTAAvPGYKVAGKTGTAQVAG-PKGGGYYDGA------QIGWFVGYAPADNPKYAFAVLID 276

                         330       340
                  ....*....|....*....|
gi 487987713  586 NGRH---GGSAAQLAKPVFD 602
Cdd:pfam00905 277 DPKRyygGKVAAPIFKDILE 296
 
Name Accession Description Interval E-value
pbp2_mrdA TIGR03423
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ...
 20-606 0e+00

penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 274573 [Multi-domain]  Cd Length: 592  Bit Score: 846.81  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713   20 RIFFAVGLVIICLLVLASRYAYLQIFHYDEFSTASDKNRIRLQPLPPARGYIYDRNGVLLADNYPVFTATLSKADVENVD 99
Cdd:TIGR03423   2 RALVLGGLVLALFGVLAARLFYLQVIRGEEYATLSEDNRIRLVPIPPPRGLILDRNGVLLADNRPSFSLEIVPEKVDDLD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713  100 TVIEQLQPILELTQEDVDRFKSRIKTARKTERVAIKLNLTETNIAKFSEVKYKFPGVRIETQMTRYYPHGDLFAHVIGYV 179
Cdd:TIGR03423  82 ATLDRLAKLLDLDPEDIARFLKELKRSRRFEPIPLKSDLTEEEVARFAVNQYRLPGVEIEARLKRYYPYGELAAHVLGYV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713  180 GRINDKELKSIDKDLYAGTNLIGKIGVEKSYEDLLHGTPGYESVEADAHSNILRHLGRKDPTRGNDLYLSLDYGLQVVAS 259
Cdd:TIGR03423 162 GEINEEDLERLEPANYAGGDYIGKSGIEKYYEDELRGKPGYREVEVNARGRVIRTLSRVPPVPGKDLVLTIDARLQQAAE 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713  260 QQLAGRRGAIVAIDPRTGEILALVSSPSFNPNLFVTGINHKDYSSLRDNIDQPLYNRAVQGVYPPGSTIKPMEAMGGLHY 339
Cdd:TIGR03423 242 KALGGRRGAVVVMDPRTGEILAMVSTPSFDPNLFVDGISSKDYKALLNDPDRPLLNRAIQGVYPPGSTFKPVVALAALEE 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713  340 GIVDWATAISDPGYFHLPGdsHKFRDWKKTGHGIVNMHKAIIMSCDTYFYILANQMGIDQMNQWMRQFGFGQKTGVDLPS 419
Cdd:TIGR03423 322 GVITPETRIYCPGYFQLGG--RRFRCWKRGGHGRVDLRKAIEESCDVYFYQLALRLGIDKIAEYAKRFGFGQKTGIDLPG 399

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713  420 ESEGLYPNPEWKMRTRKSKWMKGETISVSIGQGAFTATPLQLAMATAITANHGSHVVPHVLRAT---HGAKPFTVRNAPD 496
Cdd:TIGR03423 400 EKSGLVPSREWKRKRFGQPWYPGDTLNVSIGQGYVLVTPLQLAVATAALANGGKLYKPHLVKSIedpDGGVVRRTEPEVL 479

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713  497 GKINFNgtDEDWVKMREAMIDVIQS--GTGRGIRTPL-YQIAGKTGTAQVKSIAQGKRYNEAALSERQLDHGLFVGFAPA 573
Cdd:TIGR03423 480 RPLPIS--PENLDVVREGMRDVVNGpgGTARRARLGLpYKMAGKTGTAQVVSLKQGEKYDAEQIPERLRDHALFVAFAPY 557

                         570       580       590
                  ....*....|....*....|....*....|....
gi 487987713  574 DKPEIAIAVIWENGRHGGS-AAQLAKPVFDYWLL 606
Cdd:TIGR03423 558 DNPKIAVAVIVEHGGGGSSaAAPIARKIMDAYLL 591
FtsI COG0768
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
 10-610 0e+00

Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440531 [Multi-domain]  Cd Length: 568  Bit Score: 644.57  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713  10 IQQEKRIYRGRIFFAVGLVIICLLVLASRYAYLQIFHYDEFSTASDKNRIRLQPLPPARGYIYDRNGVLLADNYPVFTAT 89
Cdd:COG0768    3 RKKEKRLFRRRLLLLFLLVLLLFLLLVGRLFYLQVVEGDEYAELAEENRIRTVPIPAPRGLIYDRNGNVLATNVPVYSLY 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713  90 LSKADVENVDTVIEQLQPILELTQEDVDRFKSRiktaRKTERVAIKLNLTETNIAKFSevKYKFPGVRIETQMTRYYPHG 169
Cdd:COG0768   83 ADPEEVKDPEETAEKLAKLLGLDPEELRKKLKK----KSRFPVYLKRNLSPEEAARIR--ALKLPGVYVEAEYKRYYPYG 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713 170 DLFAHVIGYVGRINdkelksidkdlyaGTNLIGKIGVEKSYEDLLHGTPGYESVEADAHSNILRHLG-RKDPTRGNDLYL 248
Cdd:COG0768  157 ELAAHVLGYVGEIN-------------GGDGIGKSGLEKAYEDLLRGTPGKRRVEVDARGRVIRDLGeEKPPVPGKDLVL 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713 249 SLDYGLQVVASQQLAG-------RRGAIVAIDPRTGEILALVSSPSFNPNLFVTGINHkdysslrdnidqPLYNRAVQGV 321
Cdd:COG0768  224 TIDSDLQKIAEEALKKaveeykaKSGAVVVMDPKTGEILAMASYPSFDPNLFVGGPDE------------PLRNRAVQGT 291

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713 322 YPPGSTIKPMEAMGGLHYGIVDWATAISDPGYFHLPGdsHKFRDWKKTGHGIVNMHKAIIMSCDTYFYILANQMGIDQMN 401
Cdd:COG0768  292 YEPGSTFKPFTAAAALEEGVITPDTTFDCPGYYRVGG--RTIRDWDRGGHGTLTLTEALAKSSNVGFYKLALRLGIDKLY 369

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713 402 QWMRQFGFGQKTGVDLPSESEGLYPNPEwkmrtrksKWMKGETISVSIGQGaFTATPLQLAMATAITANHGSHVVPHVLR 481
Cdd:COG0768  370 DYLKKFGLGQKTGIDLPGEASGLLPSPK--------RWYPGETATMSIGQG-LSVTPLQLAQAYAAIANGGVLVKPHLVK 440

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713 482 ATHGAKPFTVRNAPDGK---INfngtDEDWVKMREAMIDVIQS--GTGRGIRTPLYQIAGKTGTAQVKSIAQGKRYneaa 556
Cdd:COG0768  441 EIVDPDGEVVKEEPEVLrrvIS----PETAETVREGMEGVVNEpgGTARRAAIPGYRVAGKTGTAQVVDIGNGGYY---- 512

                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 487987713 557 lserQLDH-GLFVGFAPADKPEIAIAVIWENGRHGGSAAQLAKPVF----DYWLLTRKK 610
Cdd:COG0768  513 ----KGRHiASFVGFAPADNPRYAVAVVVENPGGGAYGGTVAAPVFreimEAYLRLLGP 567
PRK10795 PRK10795
penicillin-binding protein 2; Provisional
 1-622 0e+00

penicillin-binding protein 2; Provisional


Pssm-ID: 236761 [Multi-domain]  Cd Length: 634  Bit Score: 570.94  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713   1 MKQHFPLKDIQQEKRIYRGRIFFA-VGLVIICLLVLASRYaYLQIFHYDEFSTASDKNRIRLQPLPPARGYIYDRNGVLL 79
Cdd:PRK10795   2 KKLQNSFRDYTAESALFVRRALVAfLGILLLTGVLIANLY-NLQIVRFTDYQTRSNENRIKLVPIAPSRGIIYDRNGTPL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713  80 ADNYPVFTATLSKADVENVDTVIEQLQPILELTQEDVDRFKSRIKTARKTERVAIKLNLTETNIAKFSEVKYKFPGVRIE 159
Cdd:PRK10795  81 ALNRTIYQLEMMPEKVDNLQQTLDALRSVVDLTDDDIAAFRKERARSRRFTSIPVKTNLTEVQVARFAVNQYRFPGVEVK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713 160 TQMTRYYPHGDLFAHVIGYVGRINDKELKSIDKD----LYAGTNLIGKIGVEKSYEDLLHGTPGYESVEADAHSNILRHL 235
Cdd:PRK10795 161 GYQRRYYPYGSALTHVIGYVSKINDKDVERLDKEgklaNYAATHDIGKLGIERYYEDVLHGKTGYEEVEVNNRGRVIRQL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713 236 GRKDPTRGNDLYLSLDYGLQVVASQQLAGRRGAIVAIDPRTGEILALVSSPSFNPNLFVTGINHKDYSSLRDNIDQPLYN 315
Cdd:PRK10795 241 HEQPPQAGHDIYLTLDLKLQQYIETLLAGSRAAVVVTDPRTGGILALVSTPSYDPNLFVDGISSKDYSGLLNDPNRPLIN 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713 316 RAVQGVYPPGSTIKPMEAMGGLHYGIVDWATAISDPGYFHLPGDSHKFRDWKKTGHGIVNMHKAIIMSCDTYFYILANQM 395
Cdd:PRK10795 321 RATQGVYPPASTVKPYVAVSALSAGVITRNTSLFDPGWWQLPGSEKRYRDWKKWGHGRLNVTKSLEESADTFFYQVAYDM 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713 396 GIDQMNQWMRQFGFGQKTGVDLPSESEGLYPNPEWKMRTRKSKWMKGETISVSIGQGAFTATPLQLAMATAITANHGSHV 475
Cdd:PRK10795 401 GIDRLSEWMGKFGYGHYTGIDLAEERSGNMPTREWKQKRFKKPWYQGDTIPVGIGQGYWTATPIQMSKALMTLINDGIVK 480

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713 476 VPHVLRAT--HGAK-PFT-VRNAPDGKINfNGTdedWVKMREAMIDVIQ--SGTGRG--IRTPlYQIAGKTGTAQVKSIA 547
Cdd:PRK10795 481 VPHLLMSTaeDGKQvPWVqPHEPPVGDIH-SGY---WEIAKDGMYGVANrpNGTAHKyfASAP-YKIAAKSGTAQVFGLK 555

                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 487987713 548 QGKRYNEAALSERQLDHGLFVGFAPADKPEIAIAVIWENGRHGGSAAQLAKPVFDYWLLTRKKNPIRPANHQVNG 622
Cdd:PRK10795 556 ANETYNAHKIAERLRDHKLMTAFAPYNNPQVAVAIILENGGAGPAVGTIMRQILDHIMLGDNNTDLPAENPAVAA 630
Transpeptidase pfam00905
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss: ...
 267-602 1.53e-73

Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.


Pssm-ID: 425939 [Multi-domain]  Cd Length: 296  Bit Score: 239.24  E-value: 1.53e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713  267 GAIVAIDPRTGEILALVSSPSFNPNLFVTginhkdysslrdnidqPLYNRAVQGVYPPGSTIKPMEAMGGLHYGIVDWAT 346
Cdd:pfam00905   1 GSAVVLDPKTGEVLAMVGKPSYDPNGFIG----------------PLRNRAVTSRYEPGSTFKPFTALAALDNGVLKPDE 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713  347 AISDPGYFHLPGDShkFRDWKKTGHGIVNMHKAIIMSCDTYFYILANQMGIDQMNQWMRQFGFGQKTGVDLPSESEGLYP 426
Cdd:pfam00905  65 TIFDWPGKQQGGKS--IGDWNQDQVGIGTLRQALEYSSNWYMQKLAQKLGADKLRSYLKKFGYGNKTGIGLPGENAGYLT 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713  427 NpewkmrtrksKWMKGETISVSIGqgaFTATPLQLAMATAITANHGSHVVPHVLRATHGakpfTVRNAPDGKINFngTDE 506
Cdd:pfam00905 143 P----------YWLEGATASFGIG---LTITPLQQAQAYAAIANGGKLVPPHLVKSIED----KVDPKVLNKLPI--SKS 203

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713  507 DWVKMREAMIDVIQSGTGRGIRT-PLYQIAGKTGTAQVKSiAQGKRYNEAAlserqlDHGLFVGFAPADKPEIAIAVIWE 585
Cdd:pfam00905 204 TAEKVKDMLRLVVNDGTGTGTAAvPGYKVAGKTGTAQVAG-PKGGGYYDGA------QIGWFVGYAPADNPKYAFAVLID 276

                         330       340
                  ....*....|....*....|
gi 487987713  586 NGRH---GGSAAQLAKPVFD 602
Cdd:pfam00905 277 DPKRyygGKVAAPIFKDILE 296
spoVD_pbp TIGR02214
stage V sporulation protein D; This model describes the spoVD subfamily of homologs of the ...
 21-601 7.19e-73

stage V sporulation protein D; This model describes the spoVD subfamily of homologs of the cell division protein FtsI, a penicillin binding protein. This subfamily is restricted to Bacillus subtilis and related Gram-positive species with known or suspected endospore formation capability. In these species, the functional equivalent of FtsI is desginated PBP-2B, a paralog of spoVD. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Sporulation and germination]


Pssm-ID: 131269 [Multi-domain]  Cd Length: 636  Bit Score: 247.42  E-value: 7.19e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713   21 IFFAVGLVIIcLLVLASRYAYLQIFHYDEFSTASDKNRIRLQPLPPARGYIYDRNGVLLADNYPVFTATLSKADVEN--- 97
Cdd:TIGR02214   3 IHILISFTAL-FLILILRLFYVQVFRGSFYKEMAEDQWTREIPIEAKRGRILDRNGNELAVSVSVDRVDLDPATIRKnke 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713   98 -VDTVI-EQLQPILELTQEDVdrfksrIKTARKTERVAIKLNLT----ETNIAKFSEVKYKfpGVRIETQMTRYYPHGDL 171
Cdd:TIGR02214  82 pKQREIaNELARVLEMDKEKV------FKRITKKNSPFVSAKLGrkieKDKAEKVRNLKLN--GVSVSPDSKRYYPNGDF 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713  172 FAHVIGYVGRINDkelksidkdlyagtnliGKIGVEKSYEDLLHGTPGYESVEADAHSNILRHLGR--KDPTRGNDLYLS 249
Cdd:TIGR02214 154 LSHVLGFTNSDGR-----------------GLEGLELYYDKELRGLPGVRVAEYDANSLELPYAQHayVKPVDGHDLVLT 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713  250 LDYGLQVVA---SQQLAGRRGA----IVAIDPRTGEILALVSSPSFNPNlfvtgiNHKDYSSLRDNidqplYNRAVQGVY 322
Cdd:TIGR02214 217 IDENIQYIIereADKALRERKPkgvsIIVMNPKNGEILGMSNRPTYDPN------DPRDKSPDTAR-----RNRAVSDAY 285

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713  323 PPGSTIKPMEAMGGLHYGIVDWATAISDPGYFHLPGdsHKFRDWKKTGHGIVNMHKAIIMSCDTYFYILANQMGIDQMNQ 402
Cdd:TIGR02214 286 EPGSTFKIITSSAAMEEGIVKESDKFYDDGSATVGG--KKIKCWKPGGHGSQTFPEVVQNSCNPGFIELGMRLGAEKLNN 363

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713  403 WMRQFGFGQKTGVDLPSESEGLYPNpewkmrTRKSKWMKGETIsvSIGQGAfTATPLQLAMATAITANHGSHVVPHVLRA 482
Cdd:TIGR02214 364 YILAFGFGSKTGIDLPGEAAGILVP------KKKVGPVDLATI--SFGQAN-TVTPIQLMTAVNAVANGGKLIQPHIMKE 434

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713  483 THGAKPFTVRNAPDGKINFNGTDEDWV-KMREAMIDVIQSGTGRGIRTPLYQIAGKTGTAQVKSIAQGKRYNEAALSerq 561
Cdd:TIGR02214 435 ISDSQNNAVDQTFEPEVKRQVVSKETTqKLRLALETVVSKGSGKNAFIEGYRVGGKTGTAQKVKPNGGYMEGEYIVS--- 511

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|.
gi 487987713  562 ldhglFVGFAPADKPEIAIAVIWENGRHGGS-AAQLAKPVF 601
Cdd:TIGR02214 512 -----FVGFAPADDPAVAVLVVVDNPKGVQQfGGLVAAPVF 547
PBP_dimer pfam03717
Penicillin-binding Protein dimerization domain; This domain is found at the N terminus of ...
 63-233 3.08e-52

Penicillin-binding Protein dimerization domain; This domain is found at the N terminus of Class B High Molecular Weight Penicillin-Binding Proteins. Its function has not been precisely defined, but is strongly implicated in PBP polymerization. The domain forms a largely disordered 'sugar tongs' structure.


Pssm-ID: 427460 [Multi-domain]  Cd Length: 178  Bit Score: 178.28  E-value: 3.08e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713   63 PLPPARGYIYDRNGVLLADNYPVFTATLSKADVENVD--TVIEQLQPIL----ELTQEDVDRFKSRIKTARKTERVAIKL 136
Cdd:pfam03717   1 PIPAPRGEIYDRNGVVLATNKPVYSLTITPSKLKKADalKTALKLAKLLsnyeDLDDEDLTERFLKMNSYKSYYPVVIKK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713  137 NLTETNIAKFSEVKYKFPGVRIETQMTRYYPHGDLFAHVIGYVGRINDKELKSIDKDLYAGTNLIGKIGVEKSYEDLLHG 216
Cdd:pfam03717  81 NLSEEEVARIEENLLELPGVSIETDPVRYYPYGELAAHLLGYVGEITEEELEKYLDKGYSRGDLVGKSGLEKQYESVLRG 160

                         170
                  ....*....|....*..
gi 487987713  217 TPGYESVEADAHSNILR 233
Cdd:pfam03717 161 KDGVRQVEVDALGRVIR 177
PRK15105 PRK15105
peptidoglycan synthase FtsI; Provisional
 1-640 3.66e-52

peptidoglycan synthase FtsI; Provisional


Pssm-ID: 185060 [Multi-domain]  Cd Length: 578  Bit Score: 189.65  E-value: 3.66e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713   1 MKQHFPLKDIQQEKRIYRGRIFFAV--GLVIICLLVLASRYAYLQIFHYDEFSTASDKNRIRLQPLPPARGYIYDRNGVL 78
Cdd:PRK15105   1 KAAAKTQKLKRQEEQANFISWRFALlcGCILLALVFLLGRVAWLQVINPDMLVREGDMRSLRVQEVSTSRGMITDRSGRP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713  79 LADNYPVFTATLSKADVEN-----VDTVIEQLQPILELTqedVDRFKSRIKTARKTERV--AIKLNlteTNIAKFSEvKY 151
Cdd:PRK15105  81 LAVSVPVKAIWADPKEVHDaggisVDDRWKALADALNIP---LDQLSARINANPKGRFIylARQVN---PDMADYIK-KL 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713 152 KFPGVRIETQMTRYYPHGDLFAHVIGYVgrindkelkSIDKDlyagtnliGKIGVEKSYEDLLHGTPGYESVEADAHSNI 231
Cdd:PRK15105 154 KLPGIHLREESRRYYPSGEVTAHLIGFT---------NVDSQ--------GIEGVEKSFDKWLTGQPGERIVRKDRYGRV 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713 232 LRHLGRKDPTRGNDLYLSLDYGLQVVASQQL-------AGRRGAIVAIDPRTGEILALVSSPSFNPNlfvtginhkdysS 304
Cdd:PRK15105 217 IEDISSTDSQAAHNLALSIDERLQALVYRELnnavafnKAESGSAVLVDVNTGEVLAMANSPSYNPN------------N 284

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713 305 LRDNIDQPLYNRAVQGVYPPGSTIKPMEAMGGLHYGIVDWATAISDPGYFHlpgDSHKFRDWKK----TGHGIVNMHKAI 380
Cdd:PRK15105 285 LSGTPKDAMRNRAITDVFEPGSTVKPMVVMTALQRGVVKENSVLNTVPYRI---NGHEIKDVARyselTLTGVLQKSSNV 361

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713 381 IMScdtyfyILANQMGIDQMNQWMRQFGFGQKTGVDLPSESEGLYPNpewkmrtrKSKWMKGETISVSIGQGaFTATPLQ 460
Cdd:PRK15105 362 GVS------KLALAMPSSALVDTYSRFGLGKATNLGLVGERSGLYPQ--------KQRWSDIERATFSFGYG-LMVTPLQ 426

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713 461 LAMataITANHGSHVVPHVLRATHGAKPftvrnAPDGKInfngTDEDWVKMREAMIDVIQSGTGRGIRTPL--YQIAGKT 538
Cdd:PRK15105 427 LAR---VYATIGSYGIYRPLSITKVDPP-----VPGERV----FPESIVRTVVHMMESVALPGGGGVKAAIkgYRIAIKT 494

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713 539 GTAqvKSIAQGKRYNEAALSerqldhgLFVGFAPADKPEIAIAVIWEN---GRHGGSAaqLAKPVFDywlltrkknpirp 615
Cdd:PRK15105 495 GTA--KKVGPDGRYINKYIA-------YTAGVAPASQPRFALVVVINDpqaGKYYGGA--VSAPVFG------------- 550

                        650       660
                 ....*....|....*....|....*.
gi 487987713 616 anhQVNGG-LMTAGIKPGELPSGNES 640
Cdd:PRK15105 551 ---AIMGGvLRTMNIEPDALPTGDKN 573
MrcB COG0744
Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall ...
 231-542 4.73e-32

Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440507 [Multi-domain]  Cd Length: 630  Bit Score: 131.97  E-value: 4.73e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713 231 ILRHLGRKDPTRGN-DLYLSLDYGLQVVASQQLAGR---------RGAIVAIDPRTGEILALVSSpsfnpnlfvtginhK 300
Cdd:COG0744  281 LEELLGEDDLYRGGlKIYTTLDPKLQKAAEKAVKNVlpegkpgglQAALVVVDPKTGEVLAMVGG--------------R 346

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713 301 DYSslrdnidQPLYNRAVQGVYPPGSTIKPMEAMGGLHYGIvDWATAISDPGYfHLPGDSHKFRDWKKTGHGIVNMHKAI 380
Cdd:COG0744  347 DYG-------KSQFNRATQAKRQPGSTFKPFVYAAALEQGY-TPATTVDDEPV-TFPGGGWSPKNYDGRYRGPVTLREAL 417

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713 381 IMSCDTYFYILANQMGIDQMNQWMRQFGFgqktgvdlpseSEGLYPNPewkmrtrkskwmkgetisvSIGQGAFTATPLQ 460
Cdd:COG0744  418 ANSLNTPAVRLAQEVGLDKVVDTARRLGI-----------TSPLDPNP-------------------SLALGTSEVSPLE 467

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713 461 LAMATAITANHGSHVVPHVLRAthgakpftVRNApDGKINFNGTDE------DWV--KMREAMIDVIQSGTGRGIRTPLY 532
Cdd:COG0744  468 MASAYATFANGGVYVEPHAITK--------VTDA-DGKVLYEAKPKceqvisPEVayLMTDMLQDVVTSGTGRAARLPGR 538

                        330
                 ....*....|
gi 487987713 533 QIAGKTGTAQ 542
Cdd:COG0744  539 PVAGKTGTTN 548
PBP_1a_fam TIGR02074
penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan ...
 227-601 6.75e-21

penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273955 [Multi-domain]  Cd Length: 531  Bit Score: 96.56  E-value: 6.75e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713  227 AHSNILRHLGRKDPTRGNDLYLSLDYGLQVVASQQL------AGRR------GAIVAIDPRTGEILALVSSPSFNPNLFv 294
Cdd:TIGR02074 205 VIQELEEEYGEELYTGGLKIYTTLDLDAQKAAEKVLntglrvAGRRdgddlqAALVAIDPDTGAVRALVGGRDYGKSQF- 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713  295 tginhkdysslrdnidqplyNRAVQGVYPPGSTIKPMEAMGGLHYGiVDWATAISDPGYFHLPGDSHKFRDWKKTGHGIV 374
Cdd:TIGR02074 284 --------------------NRATQAKRQPGSTFKPFVYAAALEKG-LTPATIVNDEPITYNGNGPWSPKNYGGGYRGNV 342

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713  375 NMHKAIIMSCDTYFYILANQMGIDQMNQWMRQFGFgqkTGVDLPSESEGLypnpewkmrtrkskwmkgetisvsigqGAF 454
Cdd:TIGR02074 343 TLRQALAQSRNIPAVRLLQEVGLDKVVALAKRFGI---TSPLDPVLSLAL---------------------------GTV 392

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713  455 TATPLQLAMATAITANHGSHVVPHVLRAthgakpftVRNaPDGKI--NFNGTDEDWVKMREA------MIDVIQSGTGRG 526
Cdd:TIGR02074 393 EVSPLEMASAYAVFANGGKYVEPHGIRK--------IVD-RDGKViyENKPKTTQVISPATAyimtdmLKGVVESGTGRS 463

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713  527 IRTPLYQIAGKTGTAQVKSIAqgkryneaalserqldhgLFVGFApadkPEIAIAViW-------ENGRHGGSaAQLAKP 599
Cdd:TIGR02074 464 ARLPGRPVAGKTGTTQNWRDA------------------WFVGYT----PYYVTAV-WvgyddkkTLGKSGTG-GGLAAP 519


                  ..
gi 487987713  600 VF 601
Cdd:TIGR02074 520 IW 521
MrcA COG5009
Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];
267-540 1.28e-19

Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 444033 [Multi-domain]  Cd Length: 785  Bit Score: 93.69  E-value: 1.28e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713 267 GAIVAIDPRTGEILALVSSPSFNPNLFvtginhkdysslrdnidqplyNRAVQGVYPPGSTIKPMEAMGGLHYG------ 340
Cdd:COG5009  423 GALVALDPHTGAVLALVGGFDFEQSKF---------------------NRATQAKRQPGSSFKPFVYAAALDNGytpati 481

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713 341 IVDWATAISDPGyfhlPGDSHKFRDWKKTGHGIVNMHKAI-----IMScdtyfyI-LANQMGIDQMNQWMRQFGFGQKtg 414
Cdd:COG5009  482 INDAPIVFDDGG----GGGVWRPKNYSGKFYGPTTLREALeksrnLVT------VrLLQDVGIDYVIDYAERFGIYSK-- 549

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713 415 vdLPseseglyPNPewkmrtrkskwmkgetisvSIGQGAFTATPLQLAMATAITANHGSHVVPH------------VLRA 482
Cdd:COG5009  550 --LP-------PNL-------------------SLALGSGEVTPLEMARAYAVFANGGYRVEPYlidriedrngkvIYRA 601

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 487987713 483 TH-------------GAKPFTVRNAP---DGKINFNgtdedwvkMREAMIDVIQSGTGRGIRTPLYQIAGKTGT 540
Cdd:COG5009  602 DParacedcdaaewdGAEPRLPDPAEqviDPRTAYQ--------MTSMLRGVVQRGTGRRARALGRDIAGKTGT 667
PRK14850 PRK14850
penicillin-binding protein 1b; Provisional
 243-540 7.92e-04

penicillin-binding protein 1b; Provisional


Pssm-ID: 237835 [Multi-domain]  Cd Length: 764  Bit Score: 42.53  E-value: 7.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713 243 GNDLYLSLDYGLQVVASQ-------------QLAGRRGAIVAIDPRTGEILALVSSPsfNPNLfvTGinhkdysslrdni 309
Cdd:PRK14850 379 GTKIFTTLDYISQNAAEQavkigipilkrkkRLKDLEVAMVIIDRFSGEVRALIGSS--KPEF--NG------------- 441

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713 310 dqplYNRAVQGVYPPGSTIKPmeamgglhygiVDWATAISDPGYFHL--------------PGDSHKFRDWKKTGHGIVN 375
Cdd:PRK14850 442 ----YNRALKARRSIGSLSKP-----------ITYLTALSQPEKYHLntwisdtpisikldNGQYWTPKNNNFSFSGKVM 506

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713 376 MHKAIIMSCDTYFYILANQMGIDQMNQWMRQFGFGQKTGVDLPseseglypnpewkmrtrkskwmkgetisvSIGQGAFT 455
Cdd:PRK14850 507 LIDALIHSINIPTVHLSINLGLKKLVDSWILLGISSNYITPLP-----------------------------SISLGAIN 557

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487987713 456 ATPLQLAMATAITANHGSHVVPHVLRATHGAKPFTVRNAPDGKINFNGTDEDWVKMReAMIDVIQSGTGRGIRTPL--YQ 533
Cdd:PRK14850 558 LTPMEVAQVFQIIGSGGYKSSLSSIRSIISDDNKVLYQNFPQSKHVESSQASYLTLY-AMQQVVKSGTAKSLGTIFkeFS 636


                 ....*..
gi 487987713 534 IAGKTGT 540
Cdd:PRK14850 637 LAGKTGT 643
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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