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Conserved domains on  [gi|487706778|ref|WP_001791010|]
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MULTISPECIES: tetracycline resistance determinant leader peptide [Bacteria]

Protein Classification

PRK14751 family protein( domain architecture ID 10014851)

PRK14751 family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK14751 PRK14751
tetracycline resistance determinant leader peptide; Provisional
 11-38 3.08e-11

tetracycline resistance determinant leader peptide; Provisional


:

Pssm-ID: 173212  Cd Length: 28  Bit Score: 50.40  E-value: 3.08e-11
                        10        20
                ....*....|....*....|....*...
gi 487706778 11 MLCIPMVMHKNPSDKSIYHWDFYALLGF 38
Cdd:PRK14751  1 MLCMPMVMHKNPSDKSIYHWDFYALLGF 28
 
Name Accession Description Interval E-value
PRK14751 PRK14751
tetracycline resistance determinant leader peptide; Provisional
 11-38 3.08e-11

tetracycline resistance determinant leader peptide; Provisional


Pssm-ID: 173212  Cd Length: 28  Bit Score: 50.40  E-value: 3.08e-11
                        10        20
                ....*....|....*....|....*...
gi 487706778 11 MLCIPMVMHKNPSDKSIYHWDFYALLGF 38
Cdd:PRK14751  1 MLCMPMVMHKNPSDKSIYHWDFYALLGF 28
TetM_leader pfam08076
Tetracycline resistance determinant leader peptide; This family consists of the tetracycline ...
 11-38 1.26e-10

Tetracycline resistance determinant leader peptide; This family consists of the tetracycline resistance determinant tet(M) leader peptides. A short open reading frame corresponding to a 28 amino acid peptide which contain a number of inverted repeat sequences was found immediately upstream of the tet(M). Transcriptional analyses has found that expression of tet(M) resulted from an extension of a small transcript representing the upstream leader region into the resistance determinant. Thus this leader sequence is responsible for transcriptional attenuation and thus regulation of the transcription of tet(M).


Pssm-ID: 285338  Cd Length: 28  Bit Score: 48.88  E-value: 1.26e-10
                         10        20
                 ....*....|....*....|....*...
gi 487706778  11 MLCIPMVMHKNPSDKSIYHWDFYALLGF 38
Cdd:pfam08076  1 MLCIPMVMHKNPSDKSIYHWDFYALLGF 28
 
Name Accession Description Interval E-value
PRK14751 PRK14751
tetracycline resistance determinant leader peptide; Provisional
 11-38 3.08e-11

tetracycline resistance determinant leader peptide; Provisional


Pssm-ID: 173212  Cd Length: 28  Bit Score: 50.40  E-value: 3.08e-11
                        10        20
                ....*....|....*....|....*...
gi 487706778 11 MLCIPMVMHKNPSDKSIYHWDFYALLGF 38
Cdd:PRK14751  1 MLCMPMVMHKNPSDKSIYHWDFYALLGF 28
TetM_leader pfam08076
Tetracycline resistance determinant leader peptide; This family consists of the tetracycline ...
 11-38 1.26e-10

Tetracycline resistance determinant leader peptide; This family consists of the tetracycline resistance determinant tet(M) leader peptides. A short open reading frame corresponding to a 28 amino acid peptide which contain a number of inverted repeat sequences was found immediately upstream of the tet(M). Transcriptional analyses has found that expression of tet(M) resulted from an extension of a small transcript representing the upstream leader region into the resistance determinant. Thus this leader sequence is responsible for transcriptional attenuation and thus regulation of the transcription of tet(M).


Pssm-ID: 285338  Cd Length: 28  Bit Score: 48.88  E-value: 1.26e-10
                         10        20
                 ....*....|....*....|....*...
gi 487706778  11 MLCIPMVMHKNPSDKSIYHWDFYALLGF 38
Cdd:pfam08076  1 MLCIPMVMHKNPSDKSIYHWDFYALLGF 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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