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Conserved domains on  [gi|447178723|ref|WP_001255979|]
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MULTISPECIES: cupin domain-containing protein [Bacillus]

Protein Classification

cupin domain-containing protein( domain architecture ID 10004899)

cupin domain-containing protein similar to uncharacterized Aquifex aeolicus aq_1978

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
QdoI COG1917
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
22-103 3.33e-11

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


:

Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 57.55  E-value: 3.33e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178723  22 TNDDKYWVYEVIFQSHEGIPPHSHPFGEdCAVVLSGHLDYYISNKImIRASKGEIVFGWKNHIHGYKNNETEPLHLLIFV 101
Cdd:COG1917   18 DGEDELEVVRVTFEPGARTPWHSHPGEE-LIYVLEGEGEVEVGGEE-YELKPGDVVFIPPGVPHAFRNLGDEPAVLLVVF 95


                 ..
gi 447178723 102 AP 103
Cdd:COG1917   96 SP 97
 
Name Accession Description Interval E-value
QdoI COG1917
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
22-103 3.33e-11

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 57.55  E-value: 3.33e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178723  22 TNDDKYWVYEVIFQSHEGIPPHSHPFGEdCAVVLSGHLDYYISNKImIRASKGEIVFGWKNHIHGYKNNETEPLHLLIFV 101
Cdd:COG1917   18 DGEDELEVVRVTFEPGARTPWHSHPGEE-LIYVLEGEGEVEVGGEE-YELKPGDVVFIPPGVPHAFRNLGDEPAVLLVVF 95


                 ..
gi 447178723 102 AP 103
Cdd:COG1917   96 SP 97
cupin_yp_001338853-like cd07008
Klebsiella pneumoniae yp_001338853.1 and related proteins, cupin domain; This family includes ...
 40-101 8.82e-11

Klebsiella pneumoniae yp_001338853.1 and related proteins, cupin domain; This family includes bacterial proteins homologous to Klebsiella pneumoniae yp_001338853.1, an uncharacterized conserved protein with double-stranded beta-helix domain. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380411 [Multi-domain]  Cd Length: 101  Bit Score: 56.49  E-value: 8.82e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 447178723  40 IPPHSHPFGEDCAVVLSGHLDYYISNKIMIRASKGEIVFGWKNHIHGYKNNETEPlhlLIFV 101
Cdd:cd07008   40 IAAHIHPHGQDTWIVLSGEGEYLLGDGQTVPIKAGDIVIAPAGQVHGARNTGDEP---LVFV 98
Cupin_2 pfam07883
Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ( ...
 30-98 1.25e-07

Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel).


Pssm-ID: 462300 [Multi-domain]  Cd Length: 71  Bit Score: 47.25  E-value: 1.25e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447178723   30 YEVIFQSHEGIPPHSHPFGEDCAVVLSGHLDYYISNKiMIRASKGEIVFGWKNHIHGYKNNETEPLHLL 98
Cdd:pfam07883   1 GLVTLPPGESSPPHRHPGEDEFFYVLEGEGELTVDGE-EVVLKAGDSVYFPAGVPHRFRNTGDEPARLL 68
 
Name Accession Description Interval E-value
QdoI COG1917
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
22-103 3.33e-11

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 57.55  E-value: 3.33e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178723  22 TNDDKYWVYEVIFQSHEGIPPHSHPFGEdCAVVLSGHLDYYISNKImIRASKGEIVFGWKNHIHGYKNNETEPLHLLIFV 101
Cdd:COG1917   18 DGEDELEVVRVTFEPGARTPWHSHPGEE-LIYVLEGEGEVEVGGEE-YELKPGDVVFIPPGVPHAFRNLGDEPAVLLVVF 95


                 ..
gi 447178723 102 AP 103
Cdd:COG1917   96 SP 97
cupin_yp_001338853-like cd07008
Klebsiella pneumoniae yp_001338853.1 and related proteins, cupin domain; This family includes ...
 40-101 8.82e-11

Klebsiella pneumoniae yp_001338853.1 and related proteins, cupin domain; This family includes bacterial proteins homologous to Klebsiella pneumoniae yp_001338853.1, an uncharacterized conserved protein with double-stranded beta-helix domain. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380411 [Multi-domain]  Cd Length: 101  Bit Score: 56.49  E-value: 8.82e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 447178723  40 IPPHSHPFGEDCAVVLSGHLDYYISNKIMIRASKGEIVFGWKNHIHGYKNNETEPlhlLIFV 101
Cdd:cd07008   40 IAAHIHPHGQDTWIVLSGEGEYLLGDGQTVPIKAGDIVIAPAGQVHGARNTGDEP---LVFV 98
ManC COG0662
Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];
1-116 1.97e-09

Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];


Pssm-ID: 440426 [Multi-domain]  Cd Length: 114  Bit Score: 53.22  E-value: 1.97e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178723   1 MRSFDLSQTTINISKNDLIHKTNDDKYWVYEVIFQSHEGIPPHSHPFGEDCAVVLSGHLDYYISNKImIRASKGEIVFGW 80
Cdd:COG0662    1 MQDVNIEELKAIGWGSYEVLGEGGERLSVKRITVPPGAELSLHVHPHRDEFFYVLEGTGEVTIGDEE-VELKAGDSVYIP 79

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 447178723  81 KNHIHGYKNNETEPLHLLIFVAPnkiglEYLSDDDP 116
Cdd:COG0662   80 AGVPHRLRNPGDEPLELLEVQAP-----AYLGEDDI 110
cupin_CucA-like cd20291
soluble periplasm cuproprotein CucA and related proteins, cupin domain; This family includes ...
 21-166 8.81e-08

soluble periplasm cuproprotein CucA and related proteins, cupin domain; This family includes bacterial proteins homologous to a soluble periplasm protein, CucA, found in the periplasm of the cyanobacterium Synechocystis where it shows some Cu2+-dependent quercetin dioxygenase activity. Studies show that a copper-trafficking pathway enables Cu2+ occupancy of CucA to accumulate in the periplasm, and this involves two copper transporters (CtaA and PacS) and a metallochaperone (Atx1). CucA belongs to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380425  Cd Length: 201  Bit Score: 50.03  E-value: 8.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178723  21 KTNDDKYWVYEVIFQSHEGIPPHSHP-------FGEDCAVVLSGHLDYYISNKI-----------MIRASKGEIVFGWKN 82
Cdd:cd20291   20 ETTGGGYLIAKATIPPGGGPPPHIHHytdewfyAPEGGFELFMGTNTYPDLDKVpgdnapkdtlySIPMEPGQLFYGPRN 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178723  83 HIHGYKNNETEPLHLLIFVAPNKIG---LEYLSD------DDPKIVHVPEEKRIMKLSE---YQVVHSP-FSSFERIKID 149
Cdd:cd20291  100 HVHGFVNTTDKTLPLQFVWTPDTPDggiREYFQAvggpitDLNNLPELTPKQRAAFVSEapkYGINQSSdFWQYVESVSD 179

                        170
                 ....*....|....*..
gi 447178723 150 GEYSEAYNENGLMAFID 166
Cdd:cd20291  180 KELAKLNNDDDLERLLE 196
Cupin_2 pfam07883
Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ( ...
 30-98 1.25e-07

Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel).


Pssm-ID: 462300 [Multi-domain]  Cd Length: 71  Bit Score: 47.25  E-value: 1.25e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447178723   30 YEVIFQSHEGIPPHSHPFGEDCAVVLSGHLDYYISNKiMIRASKGEIVFGWKNHIHGYKNNETEPLHLL 98
Cdd:pfam07883   1 GLVTLPPGESSPPHRHPGEDEFFYVLEGEGELTVDGE-EVVLKAGDSVYFPAGVPHRFRNTGDEPARLL 68
cupin_RmlC-like cd02208
RmlC-like cupin superfamily; This superfamily contains proteins similar to the RmlC (dTDP ...
 29-101 1.15e-06

RmlC-like cupin superfamily; This superfamily contains proteins similar to the RmlC (dTDP (deoxythymidine diphosphates)-4-dehydrorhamnose 3,5-epimerase)-like cupins. RmlC is a dTDP-sugar isomerase involved in the synthesis of L-rhamnose, a saccharide required for the virulence of some pathogenic bacteria. Cupins are a functionally diverse superfamily originally discovered based on the highly conserved motif found in germin and germin-like proteins. This conserved motif forms a beta-barrel fold found in all of the cupins, giving rise to the name cupin ('cupa' is the Latin term for small barrel). The active site of members of this superfamily is generally located at the center of a conserved barrel and usually includes a metal ion. The different functional classes in this superfamily include single domain bacterial isomerases and epimerases involved in the modification of cell wall carbohydrates, two domain bicupins such as the desiccation-tolerant seed storage globulins, and multidomain nuclear transcription factors involved in legume root nodulation.


Pssm-ID: 380338 [Multi-domain]  Cd Length: 73  Bit Score: 44.40  E-value: 1.15e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447178723  29 VYEVIFQSHEGIPPHSHPFGEDCAVVLSGHLDYYISNKIMIRASKGEIVFGWKNHIHGYKNNETEPLHLLIFV 101
Cdd:cd02208    1 ISVVTLPPGTSSPPHWHPEQDEIFYVLSGEGELTLDDGETVELKAGDIVLIPPGVPHSFVNTSDEPAVFLVVS 73
COG3837 COG3837
Uncharacterized conserved protein, cupin superfamily [Function unknown];
22-105 1.13e-05

Uncharacterized conserved protein, cupin superfamily [Function unknown];


Pssm-ID: 443048 [Multi-domain]  Cd Length: 115  Bit Score: 42.70  E-value: 1.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178723  22 TNDDKYWVYEVIFQS-HEGIPPHSHPFGEDCAVVLSGHLDYYISNKImIRASKGEIVFGWKNHIHGYKNNETEPLHLLIF 100
Cdd:COG3837   23 LGLTRLGVNLITLPPgASSSPYHAHSAEEEFVYVLEGELTLRIGGEE-YVLEPGDSVGFPAGVPHRLRNRGDEPARYLVV 101


                 ....*
gi 447178723 101 VAPNK 105
Cdd:COG3837  102 GTRAP 106
cupin_RemF-like cd06979
Streptomyces resistomycificus RemF cyclase and related proteins, cupin domain; RemF cyclase is ...
 18-103 2.17e-04

Streptomyces resistomycificus RemF cyclase and related proteins, cupin domain; RemF cyclase is a manganese-containing polyketide cyclase present in bacteria that is involved in the biosynthesis of resistomycin, the aromatic pentacyclic metabolite in Streptomyces resistomycificus. Structure of this enzyme shows a cupin fold with a conserved "jelly roll-like" beta-barrel fold that forms a homodimer. It contains an unusual octahedral zinc-binding site in a large hydrophobic pocket that may represent the active site. The zinc ion, coordinated to four histidine side chains and two water molecules, could act as a Lewis acid in the aldol condensation reaction catalyzed by RemF, reminiscent of class II aldolases.


Pssm-ID: 380384 [Multi-domain]  Cd Length: 93  Bit Score: 38.98  E-value: 2.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178723  18 LIHKTND--DKYWVYEVIFQSHEGIP-PHSHPFGEDCAVVLSGHLDYYISNKIMiRASKGEIVFGWKNHIHGYKNNETEP 94
Cdd:cd06979    6 FLDTKDGtaDRFDLFEFEVSPNAGMPpPHYHEDWEETIYGLEGSVTLTLPGKTV-EVGPGDSIFIPRGEVHGFVNRSGGP 84


                 ....*....
gi 447178723  95 LHLLIFVAP 103
Cdd:cd06979   85 TCRLCVLAP 93
cupin_TTHA0104 cd06122
Thermus thermophilus TTHA0104 and related proteins, cupin domain; This family contains ...
 35-103 8.02e-03

Thermus thermophilus TTHA0104 and related proteins, cupin domain; This family contains bacterial proteins including TTHA0104 (also called TT1209), a putative antibiotic synthesis protein from Thermus thermophilus. TTHA0104 is a cupin-like protein. The cupins are a functionally diverse superfamily originally discovered based on the highly conserved motif found in germin and germin-like proteins. This conserved motif forms a beta-barrel fold found in all of the cupins, giving rise to the name cupin (cupa is the Latin term for small barrel).


Pssm-ID: 380377 [Multi-domain]  Cd Length: 102  Bit Score: 34.45  E-value: 8.02e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178723  35 QSHegiPPHSHPfGED-CAVVLSGHLDYYISNKiMIRASKGEIVFGWKNHIHGYKNNETEPLHLLIFVAP 103
Cdd:cd06122   38 QSQ---KVHAHA-GSDkVYFVLEGEGRFTVGDE-ERELGAGEAVLAPAGVPHGVRNTGAERLVLLVFMAP 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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