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Conserved domains on  [gi|447126539|ref|WP_001203795|]
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MULTISPECIES: acyl-CoA thioesterase YbgC [Helicobacter]

Protein Classification

hotdog family protein( domain architecture ID 107)

hotdog family protein may have metabolic roles such as thioester hydrolysis in fatty acid metabolism and degradation of phenylacetic acid and the environmental pollutant 4-chlorobenzoate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
hot_dog super family cl00509
The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl ...
 2-115 1.37e-48

The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated proteins also share the hotdog fold. These proteins have related, but distinct, catalytic activities that include metabolic roles such as thioester hydrolysis in fatty acid metabolism, and degradation of phenylacetic acid and the environmental pollutant 4-chlorobenzoate. This superfamily also includes the PaaI-like protein FapR, a non-catalytic bacterial homolog involved in transcriptional regulation of fatty acid biosynthesis.


The actual alignment was detected with superfamily member TIGR00051:

Pssm-ID: 469797 [Multi-domain]  Cd Length: 117  Bit Score: 151.42  E-value: 1.37e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447126539    2 RCRVYYEDTDSEGVVYHANYLKYCERARSEFF----FKQNVLPEnEEGVFVIRSIKADFFTPASLGQVLEIRTQIKELRK 77
Cdd:TIGR00051   1 PVRVYYEDTDAQGIVYHANYLRYCERARTEFLrslgFPQSVLRA-EGVAFVVVNINIEYKKPARLDDVLEIRTQIEELNG 79

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 447126539   78 VFVVLFQEIYCIQNASLEPMKPFKVFASEIKFGFVNRS 115
Cdd:TIGR00051  80 FSFVFSQEIFNEDEALLKAATVIVVCVDPKKQKPVAIP 117
 
Name Accession Description Interval E-value
TIGR00051 TIGR00051
acyl-CoA thioester hydrolase, YbgC/YbaW family; This model describes a subset of related ...
 2-115 1.37e-48

acyl-CoA thioester hydrolase, YbgC/YbaW family; This model describes a subset of related acyl-CoA thioesterases that include several at least partially characterized proteins. YbgC is an acyl-CoA thioesterase associated with the Tol-Pal system. YbaW is part of the FadM regulon. [Unknown function, General]


Pssm-ID: 129161 [Multi-domain]  Cd Length: 117  Bit Score: 151.42  E-value: 1.37e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447126539    2 RCRVYYEDTDSEGVVYHANYLKYCERARSEFF----FKQNVLPEnEEGVFVIRSIKADFFTPASLGQVLEIRTQIKELRK 77
Cdd:TIGR00051   1 PVRVYYEDTDAQGIVYHANYLRYCERARTEFLrslgFPQSVLRA-EGVAFVVVNINIEYKKPARLDDVLEIRTQIEELNG 79

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 447126539   78 VFVVLFQEIYCIQNASLEPMKPFKVFASEIKFGFVNRS 115
Cdd:TIGR00051  80 FSFVFSQEIFNEDEALLKAATVIVVCVDPKKQKPVAIP 117
FadM COG0824
Acyl-CoA thioesterase FadM [Lipid transport and metabolism]; Acyl-CoA thioesterase FadM is ...
 1-133 2.19e-27

Acyl-CoA thioesterase FadM [Lipid transport and metabolism]; Acyl-CoA thioesterase FadM is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440586 [Multi-domain]  Cd Length: 139  Bit Score: 98.43  E-value: 2.19e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447126539   1 MRCRVYYEDTDSEGVVYHANYLKYCERARSEFFFKQNVLP---ENEEGVFVIRSIKADFFTPASLGQVLEIRTQIKELRK 77
Cdd:COG0824    8 TPIRVRFGDTDAMGHVNNANYLRYFEEARTEFLRALGLSYaelEEEGIGLVVVEAEIDYLRPARYGDELTVETRVVRLGG 87

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 447126539  78 VFVVLFQEIYCIQNASLepmkpfkVFASEIKFGFVNRSTYSPIAIPKLFKELFNAI 133
Cdd:COG0824   88 SSLTFEYEIFRADDGEL-------LATGETVLVFVDLETGRPVPLPDELRAALEAL 136
4HBT cd00586
4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate ...
 1-88 1.32e-21

4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites. There is no evidence to suggest that 4HBT is related to the type I thioesterases functioning in primary or secondary metabolic pathways. Each subunit of the 4HBT tetramer adopts a so-called hot-dog fold similar to those of beta-hydroxydecanoyl-ACP dehydratase, (R)-specific enoyl-CoA hydratase, and type II, thioesterase (TEII).


Pssm-ID: 238329 [Multi-domain]  Cd Length: 110  Bit Score: 82.65  E-value: 1.32e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447126539   1 MRCRVYYEDTDSEGVVYHANYLKYCERARSEFFFKQNVLPENEEG---VFVIRSIKADFFTPASLGQVLEIRTQIKELRK 77
Cdd:cd00586    3 LEIRVRFGDTDAAGHVNNARYLRYFEEAREEFLRELGLGYDELEEqglGLVVVELEIDYLRPLRLGDRLTVETRVLRLGR 82

                         90
                 ....*....|.
gi 447126539  78 VFVVLFQEIYC 88
Cdd:cd00586   83 KSFTFEQEIFR 93
PRK10800 PRK10800
acyl-CoA thioesterase YbgC; Provisional
 4-124 2.44e-21

acyl-CoA thioesterase YbgC; Provisional


Pssm-ID: 182742  Cd Length: 130  Bit Score: 82.87  E-value: 2.44e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447126539   4 RVYYEDTDSEGVVYHANYLKYCERARSEFF----FKQNVLPEnEEGVFVIRSIKADFFTPASLGQVLEIRTQIKELRKVF 79
Cdd:PRK10800   8 RVYYEDTDAGGVVYHASYVAFYERARTEMLrhhhFSQQALLA-ERVAFVVRKMTVEYYAPARLDDMLEVQSEITSMRGTS 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 447126539  80 VVLFQEIYCIQNASLEpmkpfkvfASEIKFGFVNRSTYSPIAIPK 124
Cdd:PRK10800  87 LTFTQRIVNAEGTLLN--------EAEVLIVCVDPLKMKPRALPK 123
4HBT pfam03061
Thioesterase superfamily; This family contains a wide variety of enzymes, principally ...
 14-87 1.70e-13

Thioesterase superfamily; This family contains a wide variety of enzymes, principally thioesterases. This family includes 4HBT (EC 3.1.2.23) which catalyzes the final step in the biosynthesis of 4-hydroxybenzoate from 4-chlorobenzoate in the soil dwelling microbe Pseudomonas CBS-3. This family includes various cytosolic long-chain acyl-CoA thioester hydrolases. Long-chain acyl-CoA hydrolases hydrolyse palmitoyl-CoA to CoA and palmitate, they also catalyze the hydrolysis of other long chain fatty acyl-CoA thioesters.


Pssm-ID: 427116 [Multi-domain]  Cd Length: 79  Bit Score: 61.12  E-value: 1.70e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 447126539   14 GVVYHANYLKYCERARSEFFFKQNvlpeNEEGVFVIRSIKADFFTPASLGQVLEIRTQIKELRKVFVVLFQEIY 87
Cdd:pfam03061   2 GVVHGGVYLALADEAAGAAARRLG----GSQQVVVVVELSIDFLRPARLGDRLTVEARVVRLGRTSAVVEVEVR 71
 
Name Accession Description Interval E-value
TIGR00051 TIGR00051
acyl-CoA thioester hydrolase, YbgC/YbaW family; This model describes a subset of related ...
 2-115 1.37e-48

acyl-CoA thioester hydrolase, YbgC/YbaW family; This model describes a subset of related acyl-CoA thioesterases that include several at least partially characterized proteins. YbgC is an acyl-CoA thioesterase associated with the Tol-Pal system. YbaW is part of the FadM regulon. [Unknown function, General]


Pssm-ID: 129161 [Multi-domain]  Cd Length: 117  Bit Score: 151.42  E-value: 1.37e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447126539    2 RCRVYYEDTDSEGVVYHANYLKYCERARSEFF----FKQNVLPEnEEGVFVIRSIKADFFTPASLGQVLEIRTQIKELRK 77
Cdd:TIGR00051   1 PVRVYYEDTDAQGIVYHANYLRYCERARTEFLrslgFPQSVLRA-EGVAFVVVNINIEYKKPARLDDVLEIRTQIEELNG 79

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 447126539   78 VFVVLFQEIYCIQNASLEPMKPFKVFASEIKFGFVNRS 115
Cdd:TIGR00051  80 FSFVFSQEIFNEDEALLKAATVIVVCVDPKKQKPVAIP 117
thio_ybgC TIGR02799
tol-pal system-associated acyl-CoA thioesterase; The tol-pal system consists of five critical ...
 1-124 4.59e-34

tol-pal system-associated acyl-CoA thioesterase; The tol-pal system consists of five critical genes. Inner membrane proteins TolQ and TolR convert protomotive force to energy that is transduced through TolA to an outer membrane complex of TolB and Pal. The system is known to be required to maintain outer membrane integrity. In a system with several homologous parts, ExbB and ExbD transduces energy through TonB to a variety of outer membrane proteins, many of which are siderophore receptors. The tol-pal system therefore may also be involved in transport. This family consists of a protein nearly always found in operons with the genes of the tol-pal system. The significance of this thioesterase to the tol-pal system is unclear, but either of two observations may be relevant. First, Pal, or peptidoglycan-associated lipoprotein, has a conserved N-terminal cleavage and acylation that makes it a lipoprotein. Second, the tol-pal system is implicated not only in the import of certain organics but also in the maintenance of outer membrane integrity (by an unknown mechanism).


Pssm-ID: 274304  Cd Length: 126  Bit Score: 115.00  E-value: 4.59e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447126539    1 MRCRVYYEDTDSEGVVYHANYLKYCERARSEFF----FKQNVLPENEEGVFVIRSIKADFFTPASLGQVLEIRTQIKELR 76
Cdd:TIGR02799   3 WPIRVYYEDTDAGGVVYHANYLRFMERARTEWLralgFEQSALLEETGLVFVVRSMELDYLKPARLDDLLTVTTRVVELK 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 447126539   77 KVFVVLFQEIYciQNASLepmkpfkVFASEIKFGFVNRSTYSPIAIPK 124
Cdd:TIGR02799  83 GASLVFAQEVR--RGDTL-------LCEATVEVACVDASDMRPRRLPA 121
FadM COG0824
Acyl-CoA thioesterase FadM [Lipid transport and metabolism]; Acyl-CoA thioesterase FadM is ...
 1-133 2.19e-27

Acyl-CoA thioesterase FadM [Lipid transport and metabolism]; Acyl-CoA thioesterase FadM is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440586 [Multi-domain]  Cd Length: 139  Bit Score: 98.43  E-value: 2.19e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447126539   1 MRCRVYYEDTDSEGVVYHANYLKYCERARSEFFFKQNVLP---ENEEGVFVIRSIKADFFTPASLGQVLEIRTQIKELRK 77
Cdd:COG0824    8 TPIRVRFGDTDAMGHVNNANYLRYFEEARTEFLRALGLSYaelEEEGIGLVVVEAEIDYLRPARYGDELTVETRVVRLGG 87

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 447126539  78 VFVVLFQEIYCIQNASLepmkpfkVFASEIKFGFVNRSTYSPIAIPKLFKELFNAI 133
Cdd:COG0824   88 SSLTFEYEIFRADDGEL-------LATGETVLVFVDLETGRPVPLPDELRAALEAL 136
4HBT cd00586
4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate ...
 1-88 1.32e-21

4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites. There is no evidence to suggest that 4HBT is related to the type I thioesterases functioning in primary or secondary metabolic pathways. Each subunit of the 4HBT tetramer adopts a so-called hot-dog fold similar to those of beta-hydroxydecanoyl-ACP dehydratase, (R)-specific enoyl-CoA hydratase, and type II, thioesterase (TEII).


Pssm-ID: 238329 [Multi-domain]  Cd Length: 110  Bit Score: 82.65  E-value: 1.32e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447126539   1 MRCRVYYEDTDSEGVVYHANYLKYCERARSEFFFKQNVLPENEEG---VFVIRSIKADFFTPASLGQVLEIRTQIKELRK 77
Cdd:cd00586    3 LEIRVRFGDTDAAGHVNNARYLRYFEEAREEFLRELGLGYDELEEqglGLVVVELEIDYLRPLRLGDRLTVETRVLRLGR 82

                         90
                 ....*....|.
gi 447126539  78 VFVVLFQEIYC 88
Cdd:cd00586   83 KSFTFEQEIFR 93
PRK10800 PRK10800
acyl-CoA thioesterase YbgC; Provisional
 4-124 2.44e-21

acyl-CoA thioesterase YbgC; Provisional


Pssm-ID: 182742  Cd Length: 130  Bit Score: 82.87  E-value: 2.44e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447126539   4 RVYYEDTDSEGVVYHANYLKYCERARSEFF----FKQNVLPEnEEGVFVIRSIKADFFTPASLGQVLEIRTQIKELRKVF 79
Cdd:PRK10800   8 RVYYEDTDAGGVVYHASYVAFYERARTEMLrhhhFSQQALLA-ERVAFVVRKMTVEYYAPARLDDMLEVQSEITSMRGTS 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 447126539  80 VVLFQEIYCIQNASLEpmkpfkvfASEIKFGFVNRSTYSPIAIPK 124
Cdd:PRK10800  87 LTFTQRIVNAEGTLLN--------EAEVLIVCVDPLKMKPRALPK 123
4HBT pfam03061
Thioesterase superfamily; This family contains a wide variety of enzymes, principally ...
 14-87 1.70e-13

Thioesterase superfamily; This family contains a wide variety of enzymes, principally thioesterases. This family includes 4HBT (EC 3.1.2.23) which catalyzes the final step in the biosynthesis of 4-hydroxybenzoate from 4-chlorobenzoate in the soil dwelling microbe Pseudomonas CBS-3. This family includes various cytosolic long-chain acyl-CoA thioester hydrolases. Long-chain acyl-CoA hydrolases hydrolyse palmitoyl-CoA to CoA and palmitate, they also catalyze the hydrolysis of other long chain fatty acyl-CoA thioesters.


Pssm-ID: 427116 [Multi-domain]  Cd Length: 79  Bit Score: 61.12  E-value: 1.70e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 447126539   14 GVVYHANYLKYCERARSEFFFKQNvlpeNEEGVFVIRSIKADFFTPASLGQVLEIRTQIKELRKVFVVLFQEIY 87
Cdd:pfam03061   2 GVVHGGVYLALADEAAGAAARRLG----GSQQVVVVVELSIDFLRPARLGDRLTVEARVVRLGRTSAVVEVEVR 71
hot_dog cd03440
The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl ...
 1-87 2.77e-11

The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated proteins also share the hotdog fold. These proteins have related, but distinct, catalytic activities that include metabolic roles such as thioester hydrolysis in fatty acid metabolism, and degradation of phenylacetic acid and the environmental pollutant 4-chlorobenzoate. This superfamily also includes the PaaI-like protein FapR, a non-catalytic bacterial homolog involved in transcriptional regulation of fatty acid biosynthesis.


Pssm-ID: 239524 [Multi-domain]  Cd Length: 100  Bit Score: 55.94  E-value: 2.77e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447126539   1 MRCRVYYEDTDSEGVVYHANYLKYCERARSEFFFKqnvlPENEEGVFVIRSIKADFFTPASLGQVLEIRTQIKELRKVFV 80
Cdd:cd03440    3 LRLTVTPEDIDGGGIVHGGLLLALADEAAGAAAAR----LGGRGLGAVTLSLDVRFLRPVRPGDTLTVEAEVVRVGRSSV 78


                 ....*..
gi 447126539  81 VLFQEIY 87
Cdd:cd03440   79 TVEVEVR 85
4HBT_2 pfam13279
Thioesterase-like superfamily; This family contains a wide variety of enzymes, principally ...
 8-130 3.07e-10

Thioesterase-like superfamily; This family contains a wide variety of enzymes, principally thioesterases. These enzymes are part of the Hotdog fold superfamily.


Pssm-ID: 463826  Cd Length: 121  Bit Score: 53.88  E-value: 3.07e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447126539    8 EDTDSEGVVYHANYLKYCERARSEFFFKQNV---LPENEEGVFVIRSIKADFFTPASLGQVLEIRTQIKELRKVFVVLFQ 84
Cdd:pfam13279   4 GDIDANGHMNNARYLRYFEEARDRFLERLGLdlaYREALGIGLILAEAHVRYRRELKLGDELTVETRLIDWDAKRFHLEH 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 447126539   85 EIYCIQNaslepmkpFKVFASEIKFGFVNRSTYSPIAIPKLFKELF 130
Cdd:pfam13279  84 RFLSPDG--------KLVATAETRLVFVDYETRKPAPIPEELLEAL 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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