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MULTISPECIES: 2-oxoglutarate dehydrogenase E1 component [Enterobacteriaceae]
Protein Classification
2-oxoglutarate dehydrogenase subunit E1 ( domain architecture ID 11484076 )
2-oxoglutarate dehydrogenase subunit E1 catalyzes the decarboxylation of 2-oxoglutarate and the formation of TPP-hydroxysuccinate
List of domain hits
Name
Accession
Description
Interval
E-value
sucA
PRK09404 2-oxoglutarate dehydrogenase E1 component; Reviewed
2-931
0e+00
2-oxoglutarate dehydrogenase E1 component; Reviewed
Pssm-ID: 236499 [Multi-domain]
Cd Length: 924
Bit Score: 1884.44
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 2 Q NSA L KAWLDSS Y L S GAN QSW IE Q LYE DF L T DPDSVD AN WR ST F QQ LPG tg V K PD QF HS QT RE Y FRRLAK D A SRY S STIS 81
Cdd:PRK09404 1 M NSA M KAWLDSS F L F GAN AAY IE E LYE QY L K DPDSVD EE WR AF F DG LPG -- V A PD VA HS AV RE S FRRLAK P A RVS S AVSD 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 82 dpdtnv K QVKVLQLINAYRFRGH QH ANLDPLGLW QQDK V AD LDP S F HD LTEAD FQE TFN V GS F A S GKET MK L G E LL EALK 161
Cdd:PRK09404 79 ------ P QVKVLQLINAYRFRGH LA ANLDPLGLW KRPD V PE LDP A F YG LTEAD LDR TFN T GS L A L GKET AT L R E II EALK 152
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 162 Q TYCG P IG A EYMHI TST EE K RW I QQRIESGR AT F NS EEKK RF L SE LTAAEG L ER Y L GA KF P G A KRFSLEGG DA LIPML K E 241
Cdd:PRK09404 153 K TYCG S IG V EYMHI SDP EE R RW L QQRIESGR PS F SA EEKK AI L ER LTAAEG F ER F L HT KF V G Q KRFSLEGG ES LIPML D E 232
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 242 M IR H AG NS G TR E V V L GMAHRGRLNVLVNVLGK K P Q DLF D EF A GKH -- K E H LG T GDVKYH M GFSSD FQ TDGG L VHL A LAFN 319
Cdd:PRK09404 233 I IR R AG KL G VK E I V I GMAHRGRLNVLVNVLGK P P R DLF A EF E GKH gp D E V LG S GDVKYH L GFSSD RE TDGG E VHL S LAFN 312
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 320 PSHLEIV S PVV I GSVRAR L DR LDEPS - SN KVLPI T IHGDAA VT GQGVV Q ETLN M S KA RGY EV GGT VR IVINNQ V GFTTS N 398
Cdd:PRK09404 313 PSHLEIV N PVV E GSVRAR Q DR RGDGQ d RK KVLPI L IHGDAA FA GQGVV A ETLN L S QL RGY RT GGT IH IVINNQ I GFTTS P 392
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 399 P l D A RSTPYCTD IG KMVQAPIFHVN A DDPEAV A F V TRLAL DF R NT FK R DV F IDLVCYRRHGHNE A DEPS A TQPLMY Q KIK 478
Cdd:PRK09404 393 P - D D RSTPYCTD VA KMVQAPIFHVN G DDPEAV V F A TRLAL EY R QK FK K DV V IDLVCYRRHGHNE G DEPS F TQPLMY K KIK 471
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 479 KHPT P R KI YADKL EQ E K V A T L E D A T EMVN L YRDALDAG DC VV A EWRP MNMHSFT WSPYL N HEWD EEYPNK V EMK RL Q ELA 558
Cdd:PRK09404 472 KHPT T R EL YADKL VA E G V I T E E E A D EMVN E YRDALDAG FE VV K EWRP ADWLAGD WSPYL G HEWD DPVDTG V PLE RL K ELA 551
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 559 KRIS TVPE AVEMQSR V A KI YG DR QA MA A GEK LF DWG G AE N LA Y A T L V DEG I PVRLSG E DSGRGTF F HRHAV I H N Q SN G S T 638
Cdd:PRK09404 552 EKLT TVPE GFKVHPK V K KI LE DR RE MA E GEK PI DWG M AE A LA F A S L L DEG Y PVRLSG Q DSGRGTF S HRHAV L H D Q KT G E T 631
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 639 Y T PL Q H IHN GQ GA F R V W DS V LSEEAVL A FEYGY A TAEP R TL T IWEAQFGDFANGAQVVIDQFISSGEQKWGR MC GLVMLL 718
Cdd:PRK09404 632 Y I PL N H LSE GQ AS F E V Y DS P LSEEAVL G FEYGY S TAEP N TL V IWEAQFGDFANGAQVVIDQFISSGEQKWGR LS GLVMLL 711
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 719 PHGYEGQGPEHSSARLER Y LQLCAE Q NMQVC V P S TPAQ VY H M LRRQALR GM R R PLVVM S PKSLLRHPLAVSSLEELA N G T 798
Cdd:PRK09404 712 PHGYEGQGPEHSSARLER F LQLCAE D NMQVC N P T TPAQ YF H L LRRQALR PF R K PLVVM T PKSLLRHPLAVSSLEELA E G S 791
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 799 F L P A IG E IDELDPK G VKRVV M CSGKVYYDLLE Q RRK NNQH DVAIVRIEQLYPFPH KAMQEV L QQFAHV K DF VWCQEEP L N 878
Cdd:PRK09404 792 F Q P V IG D IDELDPK K VKRVV L CSGKVYYDLLE A RRK RGID DVAIVRIEQLYPFPH EELAAE L AKYPNA K EV VWCQEEP K N 871
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|...
gi 447104217 879 QGAWY CS QHH FR EV I P F G AS LRYAGRPASASPAVGYMS V H Q KQQ QD LV N DAL N 931
Cdd:PRK09404 872 QGAWY FI QHH LE EV L P E G QK LRYAGRPASASPAVGYMS L H K KQQ EA LV E DAL G 924
Name
Accession
Description
Interval
E-value
sucA
PRK09404 2-oxoglutarate dehydrogenase E1 component; Reviewed
2-931
0e+00
2-oxoglutarate dehydrogenase E1 component; Reviewed
Pssm-ID: 236499 [Multi-domain]
Cd Length: 924
Bit Score: 1884.44
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 2 Q NSA L KAWLDSS Y L S GAN QSW IE Q LYE DF L T DPDSVD AN WR ST F QQ LPG tg V K PD QF HS QT RE Y FRRLAK D A SRY S STIS 81
Cdd:PRK09404 1 M NSA M KAWLDSS F L F GAN AAY IE E LYE QY L K DPDSVD EE WR AF F DG LPG -- V A PD VA HS AV RE S FRRLAK P A RVS S AVSD 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 82 dpdtnv K QVKVLQLINAYRFRGH QH ANLDPLGLW QQDK V AD LDP S F HD LTEAD FQE TFN V GS F A S GKET MK L G E LL EALK 161
Cdd:PRK09404 79 ------ P QVKVLQLINAYRFRGH LA ANLDPLGLW KRPD V PE LDP A F YG LTEAD LDR TFN T GS L A L GKET AT L R E II EALK 152
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 162 Q TYCG P IG A EYMHI TST EE K RW I QQRIESGR AT F NS EEKK RF L SE LTAAEG L ER Y L GA KF P G A KRFSLEGG DA LIPML K E 241
Cdd:PRK09404 153 K TYCG S IG V EYMHI SDP EE R RW L QQRIESGR PS F SA EEKK AI L ER LTAAEG F ER F L HT KF V G Q KRFSLEGG ES LIPML D E 232
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 242 M IR H AG NS G TR E V V L GMAHRGRLNVLVNVLGK K P Q DLF D EF A GKH -- K E H LG T GDVKYH M GFSSD FQ TDGG L VHL A LAFN 319
Cdd:PRK09404 233 I IR R AG KL G VK E I V I GMAHRGRLNVLVNVLGK P P R DLF A EF E GKH gp D E V LG S GDVKYH L GFSSD RE TDGG E VHL S LAFN 312
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 320 PSHLEIV S PVV I GSVRAR L DR LDEPS - SN KVLPI T IHGDAA VT GQGVV Q ETLN M S KA RGY EV GGT VR IVINNQ V GFTTS N 398
Cdd:PRK09404 313 PSHLEIV N PVV E GSVRAR Q DR RGDGQ d RK KVLPI L IHGDAA FA GQGVV A ETLN L S QL RGY RT GGT IH IVINNQ I GFTTS P 392
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 399 P l D A RSTPYCTD IG KMVQAPIFHVN A DDPEAV A F V TRLAL DF R NT FK R DV F IDLVCYRRHGHNE A DEPS A TQPLMY Q KIK 478
Cdd:PRK09404 393 P - D D RSTPYCTD VA KMVQAPIFHVN G DDPEAV V F A TRLAL EY R QK FK K DV V IDLVCYRRHGHNE G DEPS F TQPLMY K KIK 471
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 479 KHPT P R KI YADKL EQ E K V A T L E D A T EMVN L YRDALDAG DC VV A EWRP MNMHSFT WSPYL N HEWD EEYPNK V EMK RL Q ELA 558
Cdd:PRK09404 472 KHPT T R EL YADKL VA E G V I T E E E A D EMVN E YRDALDAG FE VV K EWRP ADWLAGD WSPYL G HEWD DPVDTG V PLE RL K ELA 551
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 559 KRIS TVPE AVEMQSR V A KI YG DR QA MA A GEK LF DWG G AE N LA Y A T L V DEG I PVRLSG E DSGRGTF F HRHAV I H N Q SN G S T 638
Cdd:PRK09404 552 EKLT TVPE GFKVHPK V K KI LE DR RE MA E GEK PI DWG M AE A LA F A S L L DEG Y PVRLSG Q DSGRGTF S HRHAV L H D Q KT G E T 631
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 639 Y T PL Q H IHN GQ GA F R V W DS V LSEEAVL A FEYGY A TAEP R TL T IWEAQFGDFANGAQVVIDQFISSGEQKWGR MC GLVMLL 718
Cdd:PRK09404 632 Y I PL N H LSE GQ AS F E V Y DS P LSEEAVL G FEYGY S TAEP N TL V IWEAQFGDFANGAQVVIDQFISSGEQKWGR LS GLVMLL 711
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 719 PHGYEGQGPEHSSARLER Y LQLCAE Q NMQVC V P S TPAQ VY H M LRRQALR GM R R PLVVM S PKSLLRHPLAVSSLEELA N G T 798
Cdd:PRK09404 712 PHGYEGQGPEHSSARLER F LQLCAE D NMQVC N P T TPAQ YF H L LRRQALR PF R K PLVVM T PKSLLRHPLAVSSLEELA E G S 791
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 799 F L P A IG E IDELDPK G VKRVV M CSGKVYYDLLE Q RRK NNQH DVAIVRIEQLYPFPH KAMQEV L QQFAHV K DF VWCQEEP L N 878
Cdd:PRK09404 792 F Q P V IG D IDELDPK K VKRVV L CSGKVYYDLLE A RRK RGID DVAIVRIEQLYPFPH EELAAE L AKYPNA K EV VWCQEEP K N 871
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|...
gi 447104217 879 QGAWY CS QHH FR EV I P F G AS LRYAGRPASASPAVGYMS V H Q KQQ QD LV N DAL N 931
Cdd:PRK09404 872 QGAWY FI QHH LE EV L P E G QK LRYAGRPASASPAVGYMS L H K KQQ EA LV E DAL G 924
SucA
COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes ...
5-932
0e+00
2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440333 [Multi-domain]
Cd Length: 935
Bit Score: 1879.39
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 5 AL KA WLD SS Y LSGAN QSW IE Q LYE DF L T DPDSVD AN WR ST F QQ LP GTGVKP D QF HS QT RE Y FR R LAK D - A SRYS S TIS DP 83
Cdd:COG0567 2 LM KA MDR SS F LSGAN AAY IE E LYE QY L E DPDSVD PS WR AF F DG LP DVPGAR D FA HS PI RE E FR K LAK N g A GAAA S AAA DP 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 84 DTNV KQV K VLQLINAYR F RGH QH A N LDPLGL WQQDK V AD LDP S F HD LTEAD FQET FN V GS FA s G K ET MK L G E LLE ALK Q T 163
Cdd:COG0567 82 EAAR KQV R VLQLINAYR V RGH LF A K LDPLGL RERPY V PE LDP A F YG LTEAD LDTV FN T GS LL - G L ET AT L R E IIA ALK E T 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 164 YCG P IG A EYMHI TST EEKRWIQ Q R I ES -- G R AT F NS EEKKR F L SE LTAAEG L E RY L GA K FP G A KRFSLEGG DA LIP M L K E 241
Cdd:COG0567 161 YCG S IG V EYMHI SDP EEKRWIQ E R L ES tr N R PS F SA EEKKR I L EK LTAAEG F E KF L HT K YV G Q KRFSLEGG ES LIP A L D E 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 242 M I RH AG NS G TR E V V L GMAHRGRLNVLVN V LGK K P Q D L F D EF A GK HK E - H LG T GDVKYH M GFSSD FQ T D GG L VHL A LAFNP 320
Cdd:COG0567 241 L I ER AG EL G VK E I V I GMAHRGRLNVLVN I LGK P P R D I F S EF E GK SA E d V LG S GDVKYH L GFSSD VE T P GG K VHL S LAFNP 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 321 SHLEIV S PVV I GSVRAR L DR LDEPSSN KVLPI T IHGDAA VT GQGVV Q ETLNMS KA RGY EV GGT VR IVINNQ V GFTTS n P L 400
Cdd:COG0567 321 SHLEIV N PVV E GSVRAR Q DR RGDTDRD KVLPI L IHGDAA FA GQGVV Y ETLNMS QL RGY RT GGT IH IVINNQ I GFTTS - P R 399
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 401 DARS TP YCTD IG KMVQAPIFHVN A DDPEAV A FV T RLALD F R NT FK R DV F IDLVCYRRHGHNE A DEP SA TQPLMY Q KIKKH 480
Cdd:COG0567 400 DARS ST YCTD VA KMVQAPIFHVN G DDPEAV V FV A RLALD Y R QK FK K DV V IDLVCYRRHGHNE G DEP AF TQPLMY K KIKKH 479
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 481 PT P R K IYADKL EQ E K V A T L E D A T EMV NL YR D ALD A G DC VV A E WR P M -- NMHSFT WSPY -- L NHE WD EEYPNK V EMKR L Q E 556
Cdd:COG0567 480 PT T R E IYADKL VA E G V I T A E E A D EMV DE YR A ALD E G FE VV K E YK P N ka DWLEGD WSPY rr L GED WD DPVDTG V PLEK L K E 559
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 557 L AKRIS T V PE AVEMQSR V A KI YG DR QA MA A GEK LF DWG G AE N LAYA T L V DEG I PVRLSG E DSGRGTF F HRHAV I H N Q SN G 636
Cdd:COG0567 560 L GEKLT T L PE GFKLHPK V E KI LE DR RK MA E GEK PL DWG M AE A LAYA S L L DEG Y PVRLSG Q DSGRGTF S HRHAV L H D Q KT G 639
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 637 S TY T PL Q H IHN GQ GA F R V WD S V LSEEAVL A FEYGYA T AEP R TL T IWEAQFGDFANGAQVVIDQFISSGE Q KWGR MC GLVM 716
Cdd:COG0567 640 E TY V PL N H LSE GQ AR F E V YN S L LSEEAVL G FEYGYA L AEP N TL V IWEAQFGDFANGAQVVIDQFISSGE S KWGR LS GLVM 719
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 717 LLPHGYEGQGPEHSSARLER Y LQLCAE Q NMQVC V P S TPAQ VY H M LRRQ AL R GM R R PL V VM S PKSLLRH P LAVSSLEELA N 796
Cdd:COG0567 720 LLPHGYEGQGPEHSSARLER F LQLCAE D NMQVC N P T TPAQ YF H L LRRQ MK R PF R K PL I VM T PKSLLRH K LAVSSLEELA E 799
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 797 G T F LPA I GEI DELDPK G VKRVV M CSGKVYYDLLE Q RR KNNQH DVAIVRIEQLYPFP HKAMQEV L QQFAHV K DF VWCQEEP 876
Cdd:COG0567 800 G S F QEV I DDT DELDPK K VKRVV L CSGKVYYDLLE E RR ERGRD DVAIVRIEQLYPFP EEELAAE L AKYPNA K EV VWCQEEP 879
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|....*.
gi 447104217 877 L N Q GAWY CS QH HFR EV I P F G AS LRYAGRPASASPA V GYMSVH QKQ Q QD LV ND AL NV 932
Cdd:COG0567 880 K N M GAWY FI QH RLE EV L P K G QR LRYAGRPASASPA T GYMSVH KAE Q KA LV EE AL GI 935
2oxo_dh_E1
TIGR00239 2-oxoglutarate dehydrogenase, E1 component; The 2-oxoglutarate dehydrogenase complex consists ...
14-930
0e+00
2-oxoglutarate dehydrogenase, E1 component; The 2-oxoglutarate dehydrogenase complex consists of this thiamine pyrophosphate-binding subunit (E1), dihydrolipoamide succinyltransferase (E2), and lipoamide dehydrogenase (E3). The E1 ortholog from Corynebacterium glutamicum is unusual in having an N-terminal extension that resembles the dihydrolipoamide succinyltransferase (E2) component of 2-oxoglutarate dehydrogenase. [Energy metabolism, TCA cycle]
Pssm-ID: 161785 [Multi-domain]
Cd Length: 929
Bit Score: 1741.28
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 14 YLSGANQS W IE Q LYED F LTDPDSVDA N WRSTF Q QLPG T G VK PDQFHS Q TR E YFRRLAKDASR Y S S TISDPDTNV K QVKVL 93
Cdd:TIGR00239 1 YLSGANQS Y IE E LYED Y LTDPDSVDA S WRSTF D QLPG P G PA PDQFHS P TR S YFRRLAKDASR G S V TISDPDTNV S QVKVL 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 94 QLI N AYRFRGH Q HANLDPLGL W QQDKV AD LD P SF HD LTEAD F QETFN V GSF A SGK E - TMKL G -- ELL E ALKQTYCG P IGA 170
Cdd:TIGR00239 81 QLI R AYRFRGH L HANLDPLGL K QQDKV PE LD L SF YG LTEAD L QETFN I GSF V SGK D a TMKL S nl ELL Q ALKQTYCG S IGA 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 171 EYMHITSTEEKRW I QQRIESG - RA T FNSEEKKRFLS E LTAAEG L ER Y LGAKFPGAKRFSLEG G DAL I PMLKE M IRH AG NS 249
Cdd:TIGR00239 161 EYMHITSTEEKRW L QQRIESG e RA Q FNSEEKKRFLS R LTAAEG F ER F LGAKFPGAKRFSLEG L DAL V PMLKE I IRH SV NS 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 250 GTR E VVLGMAHRGRLNVLVNVLGK K P Q D L F D EFAGKHK E HL -- GTGDVKYHMG - FSSDF Q TDG G LVHLALAFNPSHLEIV 326
Cdd:TIGR00239 241 GTR D VVLGMAHRGRLNVLVNVLGK P P E D I F S EFAGKHK S HL pd GTGDVKYHMG r FSSDF T TDG K LVHLALAFNPSHLEIV 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 327 SPVVIGS V RARLDRL DE - P S S N KVL P I T IHGDAA VT GQGVVQETLNMSK A RGY E VGGT VR I V INNQ V GFTT s NPLDARST 405
Cdd:TIGR00239 321 SPVVIGS T RARLDRL ND s P E S T KVL A I L IHGDAA FA GQGVVQETLNMSK L RGY S VGGT IH I I INNQ I GFTT - NPLDARST 399
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 406 PYC T D IG KM V QAPIFHVNADDPEAVAF V TRLA LDF RNTFKRDVFIDLV C YRRHGHNEADEPSATQPLMYQKIKKHPTPRK 485
Cdd:TIGR00239 400 PYC S D LA KM I QAPIFHVNADDPEAVAF A TRLA VEY RNTFKRDVFIDLV G YRRHGHNEADEPSATQPLMYQKIKKHPTPRK 479
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 486 I YADKL EQ E K VAT L ED A TEMVNLYRDAL D A G DCVV AE WR P MN MH SFTWSP Y LNHEWDEEYPNKVEMKRLQELAKRIS T VP 565
Cdd:TIGR00239 480 V YADKL VS E G VAT E ED V TEMVNLYRDAL E A A DCVV PS WR E MN TA SFTWSP E LNHEWDEEYPNKVEMKRLQELAKRIS E VP 559
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 566 E A VEM Q SRVAKIY G DR - Q AMAAGEKLFDWGGAENLA Y ATLVD E GIPVRLSGEDS G RGTFF H RHAV I H N QSNGSTYTPLQH 644
Cdd:TIGR00239 560 E G VEM H SRVAKIY F DR t K AMAAGEKLFDWGGAENLA F ATLVD D GIPVRLSGEDS E RGTFF Q RHAV L H D QSNGSTYTPLQH 639
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 645 I HNGQGAFRVW D SVLSEE A VL A FEYGYAT AE PRTL T IWEAQFGDFANGAQVVIDQFISSGEQKWG R M C GLVMLLPHGYEG 724
Cdd:TIGR00239 640 L HNGQGAFRVW N SVLSEE S VL G FEYGYAT TS PRTL V IWEAQFGDFANGAQVVIDQFISSGEQKWG Q M S GLVMLLPHGYEG 719
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 725 QGPEHSS A RLER Y LQL C AEQNMQVCVP S TPAQV Y H M LRRQALRGMRRPLVVMSPKSLLRHPLAVSSLEELA N GTF L P A IG 804
Cdd:TIGR00239 720 QGPEHSS G RLER F LQL A AEQNMQVCVP T TPAQV F H I LRRQALRGMRRPLVVMSPKSLLRHPLAVSSLEELA E GTF Q P V IG 799
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 805 EI D E ---- LDP K GVKR V V M CSGKVYYDL L EQRRKN N Q H DVAIVRIEQLYPFPHKA MQ EVLQQ FAHV K DF VWCQEEPLN Q G 880
Cdd:TIGR00239 800 EI E E sgls LDP E GVKR L V L CSGKVYYDL H EQRRKN G Q K DVAIVRIEQLYPFPHKA VK EVLQQ YPNL K EI VWCQEEPLN M G 879
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|
gi 447104217 881 AWY C SQ H H F REVIP F G A S L RYAGRPASASPAVGYMS V HQKQQQDL V NDAL 930
Cdd:TIGR00239 880 AWY Y SQ P H L REVIP E G V S V RYAGRPASASPAVGYMS L HQKQQQDL L NDAL 929
TPP_E1_OGDC_like
cd02016 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed ...
213-474
2.34e-161
Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of the tricarboxylic acid cycle.
Pssm-ID: 238974 [Multi-domain]
Cd Length: 265
Bit Score: 472.78
E-value: 2.34e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 213 L E RY L GA KFPG A KRF S LEG GDA LIP M L K E M I RH A GNS G TR EVV L GMAHRGRLNVL V NVLGK KPQDL F D EF A GK HK -- E H - 289
Cdd:cd02016 1 F E QF L AT KFPG Q KRF G LEG AES LIP A L D E L I DR A AEL G VE EVV I GMAHRGRLNVL A NVLGK PLEQI F S EF E GK SE fp E D d 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 290 L G T GDVKYH M G F SSD FQ T D - G GL VHL A LA F NPSHLE I V S PVV I G SV RA RL D RLDEPSSN KVLPI T IHGDAA VT GQGVV Q E 368
Cdd:cd02016 81 E G S GDVKYH L G Y SSD RK T P s G KK VHL S LA P NPSHLE A V N PVV M G KT RA KQ D YRGDGERD KVLPI L IHGDAA FA GQGVV Y E 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 369 TLN M S KAR GY EV GGT VR IV I NNQ V GFTT s N P L D A RS T PYCTD IG KM VQ APIFHVN A DDPEAV AFV TRLAL DF R NT FK R DV 448
Cdd:cd02016 161 TLN L S NLP GY TT GGT IH IV V NNQ I GFTT - D P R D S RS S PYCTD VA KM IG APIFHVN G DDPEAV VRA TRLAL EY R QK FK K DV 239
250 260
....*....|....*....|....*.
gi 447104217 449 F IDLVCYRRHGHNE A DEPS A TQPLMY 474
Cdd:cd02016 240 V IDLVCYRRHGHNE L DEPS F TQPLMY 265
OxoGdeHyase_C
pfam16870 2-oxoglutarate dehydrogenase C-terminal; OxoGdeHyase_C is a family found immediately ...
788-930
1.88e-78
2-oxoglutarate dehydrogenase C-terminal; OxoGdeHyase_C is a family found immediately C-terminal to Transket_pyr, pfam02779. It is found at the C-terminus of 2-oxoglutarate dehydrogenase.
Pssm-ID: 465289 [Multi-domain]
Cd Length: 147
Bit Score: 251.21
E-value: 1.88e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 788 V SSLEE LAN GT - F LPA I GEIDE L - DP KG VKRVV M CSGKVYYDLL EQ R RKNNQ - H DVAIVRIEQLYPFP HKAMQ E V L QQFA 864
Cdd:pfam16870 1 R SSLEE FTP GT h F QRV I PDPEP L v DP EK VKRVV L CSGKVYYDLL KE R EERGG i K DVAIVRIEQLYPFP FDLLK E E L DKYP 80
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 447104217 865 HVKDF VWCQEEP L NQGAW YCS Q HHFRE V IP - F G AS LRYAGRP A SASPA V G YM SVH QKQ Q QD L VN DA L 930
Cdd:pfam16870 81 NAAEI VWCQEEP K NQGAW SFV Q PRLET V LN e T G HR LRYAGRP P SASPA T G SK SVH LAE Q EA L LD DA F 147
Transket_pyr
smart00861 Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer ...
655-783
4.00e-30
Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer of a two-carbon ketol unit from xylulose 5-phosphate to an aldose receptor, such as ribose 5-phosphate, to form sedoheptulose 7-phosphate and glyceraldehyde 3- phosphate. This enzyme, together with transaldolase, provides a link between the glycolytic and pentose-phosphate pathways. TK requires thiamine pyrophosphate as a cofactor. In most sources where TK has been purified, it is a homodimer of approximately 70 Kd subunits. TK sequences from a variety of eukaryotic and prokaryotic sources show that the enzyme has been evolutionarily conserved. In the peroxisomes of methylotrophic yeast Hansenula polymorpha, there is a highly related enzyme, dihydroxy-acetone synthase (DHAS) (also known as formaldehyde transketolase), which exhibits a very unusual specificity by including formaldehyde amongst its substrates.
Pssm-ID: 214865 [Multi-domain]
Cd Length: 136
Bit Score: 116.05
E-value: 4.00e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 655 W D SVLS E E A VLA F EY G Y A TAE prt L TIWEAQ F GD F ANG A QVV I DQFIS SG E qkwgr MCGLVMLLPH G YE G Q - GP E H S S AR 733
Cdd:smart00861 18 I D TGIA E Q A MVG F AA G L A LHG --- L RPVVEI F FT F FDR A KDQ I RSAGA SG N ----- VPVVFRHDGG G GV G E d GP T H H S IE 89
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 447104217 734 L E - RYLQLC aeq NMQ V CV PS T PA QVYHM LR R q A L R GMRRPLVVMSP KSL L R 783
Cdd:smart00861 90 D E a LLRAIP --- GLK V VA PS D PA EAKGL LR A - A I R DDGPVVIRLER KSL Y R 136
Name
Accession
Description
Interval
E-value
sucA
PRK09404 2-oxoglutarate dehydrogenase E1 component; Reviewed
2-931
0e+00
2-oxoglutarate dehydrogenase E1 component; Reviewed
Pssm-ID: 236499 [Multi-domain]
Cd Length: 924
Bit Score: 1884.44
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 2 Q NSA L KAWLDSS Y L S GAN QSW IE Q LYE DF L T DPDSVD AN WR ST F QQ LPG tg V K PD QF HS QT RE Y FRRLAK D A SRY S STIS 81
Cdd:PRK09404 1 M NSA M KAWLDSS F L F GAN AAY IE E LYE QY L K DPDSVD EE WR AF F DG LPG -- V A PD VA HS AV RE S FRRLAK P A RVS S AVSD 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 82 dpdtnv K QVKVLQLINAYRFRGH QH ANLDPLGLW QQDK V AD LDP S F HD LTEAD FQE TFN V GS F A S GKET MK L G E LL EALK 161
Cdd:PRK09404 79 ------ P QVKVLQLINAYRFRGH LA ANLDPLGLW KRPD V PE LDP A F YG LTEAD LDR TFN T GS L A L GKET AT L R E II EALK 152
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 162 Q TYCG P IG A EYMHI TST EE K RW I QQRIESGR AT F NS EEKK RF L SE LTAAEG L ER Y L GA KF P G A KRFSLEGG DA LIPML K E 241
Cdd:PRK09404 153 K TYCG S IG V EYMHI SDP EE R RW L QQRIESGR PS F SA EEKK AI L ER LTAAEG F ER F L HT KF V G Q KRFSLEGG ES LIPML D E 232
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 242 M IR H AG NS G TR E V V L GMAHRGRLNVLVNVLGK K P Q DLF D EF A GKH -- K E H LG T GDVKYH M GFSSD FQ TDGG L VHL A LAFN 319
Cdd:PRK09404 233 I IR R AG KL G VK E I V I GMAHRGRLNVLVNVLGK P P R DLF A EF E GKH gp D E V LG S GDVKYH L GFSSD RE TDGG E VHL S LAFN 312
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 320 PSHLEIV S PVV I GSVRAR L DR LDEPS - SN KVLPI T IHGDAA VT GQGVV Q ETLN M S KA RGY EV GGT VR IVINNQ V GFTTS N 398
Cdd:PRK09404 313 PSHLEIV N PVV E GSVRAR Q DR RGDGQ d RK KVLPI L IHGDAA FA GQGVV A ETLN L S QL RGY RT GGT IH IVINNQ I GFTTS P 392
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 399 P l D A RSTPYCTD IG KMVQAPIFHVN A DDPEAV A F V TRLAL DF R NT FK R DV F IDLVCYRRHGHNE A DEPS A TQPLMY Q KIK 478
Cdd:PRK09404 393 P - D D RSTPYCTD VA KMVQAPIFHVN G DDPEAV V F A TRLAL EY R QK FK K DV V IDLVCYRRHGHNE G DEPS F TQPLMY K KIK 471
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 479 KHPT P R KI YADKL EQ E K V A T L E D A T EMVN L YRDALDAG DC VV A EWRP MNMHSFT WSPYL N HEWD EEYPNK V EMK RL Q ELA 558
Cdd:PRK09404 472 KHPT T R EL YADKL VA E G V I T E E E A D EMVN E YRDALDAG FE VV K EWRP ADWLAGD WSPYL G HEWD DPVDTG V PLE RL K ELA 551
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 559 KRIS TVPE AVEMQSR V A KI YG DR QA MA A GEK LF DWG G AE N LA Y A T L V DEG I PVRLSG E DSGRGTF F HRHAV I H N Q SN G S T 638
Cdd:PRK09404 552 EKLT TVPE GFKVHPK V K KI LE DR RE MA E GEK PI DWG M AE A LA F A S L L DEG Y PVRLSG Q DSGRGTF S HRHAV L H D Q KT G E T 631
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 639 Y T PL Q H IHN GQ GA F R V W DS V LSEEAVL A FEYGY A TAEP R TL T IWEAQFGDFANGAQVVIDQFISSGEQKWGR MC GLVMLL 718
Cdd:PRK09404 632 Y I PL N H LSE GQ AS F E V Y DS P LSEEAVL G FEYGY S TAEP N TL V IWEAQFGDFANGAQVVIDQFISSGEQKWGR LS GLVMLL 711
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 719 PHGYEGQGPEHSSARLER Y LQLCAE Q NMQVC V P S TPAQ VY H M LRRQALR GM R R PLVVM S PKSLLRHPLAVSSLEELA N G T 798
Cdd:PRK09404 712 PHGYEGQGPEHSSARLER F LQLCAE D NMQVC N P T TPAQ YF H L LRRQALR PF R K PLVVM T PKSLLRHPLAVSSLEELA E G S 791
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 799 F L P A IG E IDELDPK G VKRVV M CSGKVYYDLLE Q RRK NNQH DVAIVRIEQLYPFPH KAMQEV L QQFAHV K DF VWCQEEP L N 878
Cdd:PRK09404 792 F Q P V IG D IDELDPK K VKRVV L CSGKVYYDLLE A RRK RGID DVAIVRIEQLYPFPH EELAAE L AKYPNA K EV VWCQEEP K N 871
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|...
gi 447104217 879 QGAWY CS QHH FR EV I P F G AS LRYAGRPASASPAVGYMS V H Q KQQ QD LV N DAL N 931
Cdd:PRK09404 872 QGAWY FI QHH LE EV L P E G QK LRYAGRPASASPAVGYMS L H K KQQ EA LV E DAL G 924
SucA
COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes ...
5-932
0e+00
2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440333 [Multi-domain]
Cd Length: 935
Bit Score: 1879.39
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 5 AL KA WLD SS Y LSGAN QSW IE Q LYE DF L T DPDSVD AN WR ST F QQ LP GTGVKP D QF HS QT RE Y FR R LAK D - A SRYS S TIS DP 83
Cdd:COG0567 2 LM KA MDR SS F LSGAN AAY IE E LYE QY L E DPDSVD PS WR AF F DG LP DVPGAR D FA HS PI RE E FR K LAK N g A GAAA S AAA DP 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 84 DTNV KQV K VLQLINAYR F RGH QH A N LDPLGL WQQDK V AD LDP S F HD LTEAD FQET FN V GS FA s G K ET MK L G E LLE ALK Q T 163
Cdd:COG0567 82 EAAR KQV R VLQLINAYR V RGH LF A K LDPLGL RERPY V PE LDP A F YG LTEAD LDTV FN T GS LL - G L ET AT L R E IIA ALK E T 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 164 YCG P IG A EYMHI TST EEKRWIQ Q R I ES -- G R AT F NS EEKKR F L SE LTAAEG L E RY L GA K FP G A KRFSLEGG DA LIP M L K E 241
Cdd:COG0567 161 YCG S IG V EYMHI SDP EEKRWIQ E R L ES tr N R PS F SA EEKKR I L EK LTAAEG F E KF L HT K YV G Q KRFSLEGG ES LIP A L D E 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 242 M I RH AG NS G TR E V V L GMAHRGRLNVLVN V LGK K P Q D L F D EF A GK HK E - H LG T GDVKYH M GFSSD FQ T D GG L VHL A LAFNP 320
Cdd:COG0567 241 L I ER AG EL G VK E I V I GMAHRGRLNVLVN I LGK P P R D I F S EF E GK SA E d V LG S GDVKYH L GFSSD VE T P GG K VHL S LAFNP 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 321 SHLEIV S PVV I GSVRAR L DR LDEPSSN KVLPI T IHGDAA VT GQGVV Q ETLNMS KA RGY EV GGT VR IVINNQ V GFTTS n P L 400
Cdd:COG0567 321 SHLEIV N PVV E GSVRAR Q DR RGDTDRD KVLPI L IHGDAA FA GQGVV Y ETLNMS QL RGY RT GGT IH IVINNQ I GFTTS - P R 399
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 401 DARS TP YCTD IG KMVQAPIFHVN A DDPEAV A FV T RLALD F R NT FK R DV F IDLVCYRRHGHNE A DEP SA TQPLMY Q KIKKH 480
Cdd:COG0567 400 DARS ST YCTD VA KMVQAPIFHVN G DDPEAV V FV A RLALD Y R QK FK K DV V IDLVCYRRHGHNE G DEP AF TQPLMY K KIKKH 479
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 481 PT P R K IYADKL EQ E K V A T L E D A T EMV NL YR D ALD A G DC VV A E WR P M -- NMHSFT WSPY -- L NHE WD EEYPNK V EMKR L Q E 556
Cdd:COG0567 480 PT T R E IYADKL VA E G V I T A E E A D EMV DE YR A ALD E G FE VV K E YK P N ka DWLEGD WSPY rr L GED WD DPVDTG V PLEK L K E 559
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 557 L AKRIS T V PE AVEMQSR V A KI YG DR QA MA A GEK LF DWG G AE N LAYA T L V DEG I PVRLSG E DSGRGTF F HRHAV I H N Q SN G 636
Cdd:COG0567 560 L GEKLT T L PE GFKLHPK V E KI LE DR RK MA E GEK PL DWG M AE A LAYA S L L DEG Y PVRLSG Q DSGRGTF S HRHAV L H D Q KT G 639
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 637 S TY T PL Q H IHN GQ GA F R V WD S V LSEEAVL A FEYGYA T AEP R TL T IWEAQFGDFANGAQVVIDQFISSGE Q KWGR MC GLVM 716
Cdd:COG0567 640 E TY V PL N H LSE GQ AR F E V YN S L LSEEAVL G FEYGYA L AEP N TL V IWEAQFGDFANGAQVVIDQFISSGE S KWGR LS GLVM 719
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 717 LLPHGYEGQGPEHSSARLER Y LQLCAE Q NMQVC V P S TPAQ VY H M LRRQ AL R GM R R PL V VM S PKSLLRH P LAVSSLEELA N 796
Cdd:COG0567 720 LLPHGYEGQGPEHSSARLER F LQLCAE D NMQVC N P T TPAQ YF H L LRRQ MK R PF R K PL I VM T PKSLLRH K LAVSSLEELA E 799
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 797 G T F LPA I GEI DELDPK G VKRVV M CSGKVYYDLLE Q RR KNNQH DVAIVRIEQLYPFP HKAMQEV L QQFAHV K DF VWCQEEP 876
Cdd:COG0567 800 G S F QEV I DDT DELDPK K VKRVV L CSGKVYYDLLE E RR ERGRD DVAIVRIEQLYPFP EEELAAE L AKYPNA K EV VWCQEEP 879
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|....*.
gi 447104217 877 L N Q GAWY CS QH HFR EV I P F G AS LRYAGRPASASPA V GYMSVH QKQ Q QD LV ND AL NV 932
Cdd:COG0567 880 K N M GAWY FI QH RLE EV L P K G QR LRYAGRPASASPA T GYMSVH KAE Q KA LV EE AL GI 935
2oxo_dh_E1
TIGR00239 2-oxoglutarate dehydrogenase, E1 component; The 2-oxoglutarate dehydrogenase complex consists ...
14-930
0e+00
2-oxoglutarate dehydrogenase, E1 component; The 2-oxoglutarate dehydrogenase complex consists of this thiamine pyrophosphate-binding subunit (E1), dihydrolipoamide succinyltransferase (E2), and lipoamide dehydrogenase (E3). The E1 ortholog from Corynebacterium glutamicum is unusual in having an N-terminal extension that resembles the dihydrolipoamide succinyltransferase (E2) component of 2-oxoglutarate dehydrogenase. [Energy metabolism, TCA cycle]
Pssm-ID: 161785 [Multi-domain]
Cd Length: 929
Bit Score: 1741.28
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 14 YLSGANQS W IE Q LYED F LTDPDSVDA N WRSTF Q QLPG T G VK PDQFHS Q TR E YFRRLAKDASR Y S S TISDPDTNV K QVKVL 93
Cdd:TIGR00239 1 YLSGANQS Y IE E LYED Y LTDPDSVDA S WRSTF D QLPG P G PA PDQFHS P TR S YFRRLAKDASR G S V TISDPDTNV S QVKVL 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 94 QLI N AYRFRGH Q HANLDPLGL W QQDKV AD LD P SF HD LTEAD F QETFN V GSF A SGK E - TMKL G -- ELL E ALKQTYCG P IGA 170
Cdd:TIGR00239 81 QLI R AYRFRGH L HANLDPLGL K QQDKV PE LD L SF YG LTEAD L QETFN I GSF V SGK D a TMKL S nl ELL Q ALKQTYCG S IGA 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 171 EYMHITSTEEKRW I QQRIESG - RA T FNSEEKKRFLS E LTAAEG L ER Y LGAKFPGAKRFSLEG G DAL I PMLKE M IRH AG NS 249
Cdd:TIGR00239 161 EYMHITSTEEKRW L QQRIESG e RA Q FNSEEKKRFLS R LTAAEG F ER F LGAKFPGAKRFSLEG L DAL V PMLKE I IRH SV NS 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 250 GTR E VVLGMAHRGRLNVLVNVLGK K P Q D L F D EFAGKHK E HL -- GTGDVKYHMG - FSSDF Q TDG G LVHLALAFNPSHLEIV 326
Cdd:TIGR00239 241 GTR D VVLGMAHRGRLNVLVNVLGK P P E D I F S EFAGKHK S HL pd GTGDVKYHMG r FSSDF T TDG K LVHLALAFNPSHLEIV 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 327 SPVVIGS V RARLDRL DE - P S S N KVL P I T IHGDAA VT GQGVVQETLNMSK A RGY E VGGT VR I V INNQ V GFTT s NPLDARST 405
Cdd:TIGR00239 321 SPVVIGS T RARLDRL ND s P E S T KVL A I L IHGDAA FA GQGVVQETLNMSK L RGY S VGGT IH I I INNQ I GFTT - NPLDARST 399
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 406 PYC T D IG KM V QAPIFHVNADDPEAVAF V TRLA LDF RNTFKRDVFIDLV C YRRHGHNEADEPSATQPLMYQKIKKHPTPRK 485
Cdd:TIGR00239 400 PYC S D LA KM I QAPIFHVNADDPEAVAF A TRLA VEY RNTFKRDVFIDLV G YRRHGHNEADEPSATQPLMYQKIKKHPTPRK 479
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 486 I YADKL EQ E K VAT L ED A TEMVNLYRDAL D A G DCVV AE WR P MN MH SFTWSP Y LNHEWDEEYPNKVEMKRLQELAKRIS T VP 565
Cdd:TIGR00239 480 V YADKL VS E G VAT E ED V TEMVNLYRDAL E A A DCVV PS WR E MN TA SFTWSP E LNHEWDEEYPNKVEMKRLQELAKRIS E VP 559
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 566 E A VEM Q SRVAKIY G DR - Q AMAAGEKLFDWGGAENLA Y ATLVD E GIPVRLSGEDS G RGTFF H RHAV I H N QSNGSTYTPLQH 644
Cdd:TIGR00239 560 E G VEM H SRVAKIY F DR t K AMAAGEKLFDWGGAENLA F ATLVD D GIPVRLSGEDS E RGTFF Q RHAV L H D QSNGSTYTPLQH 639
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 645 I HNGQGAFRVW D SVLSEE A VL A FEYGYAT AE PRTL T IWEAQFGDFANGAQVVIDQFISSGEQKWG R M C GLVMLLPHGYEG 724
Cdd:TIGR00239 640 L HNGQGAFRVW N SVLSEE S VL G FEYGYAT TS PRTL V IWEAQFGDFANGAQVVIDQFISSGEQKWG Q M S GLVMLLPHGYEG 719
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 725 QGPEHSS A RLER Y LQL C AEQNMQVCVP S TPAQV Y H M LRRQALRGMRRPLVVMSPKSLLRHPLAVSSLEELA N GTF L P A IG 804
Cdd:TIGR00239 720 QGPEHSS G RLER F LQL A AEQNMQVCVP T TPAQV F H I LRRQALRGMRRPLVVMSPKSLLRHPLAVSSLEELA E GTF Q P V IG 799
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 805 EI D E ---- LDP K GVKR V V M CSGKVYYDL L EQRRKN N Q H DVAIVRIEQLYPFPHKA MQ EVLQQ FAHV K DF VWCQEEPLN Q G 880
Cdd:TIGR00239 800 EI E E sgls LDP E GVKR L V L CSGKVYYDL H EQRRKN G Q K DVAIVRIEQLYPFPHKA VK EVLQQ YPNL K EI VWCQEEPLN M G 879
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|
gi 447104217 881 AWY C SQ H H F REVIP F G A S L RYAGRPASASPAVGYMS V HQKQQQDL V NDAL 930
Cdd:TIGR00239 880 AWY Y SQ P H L REVIP E G V S V RYAGRPASASPAVGYMS L HQKQQQDL L NDAL 929
kgd
PRK12270 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
68-930
0e+00
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;
Pssm-ID: 237030 [Multi-domain]
Cd Length: 1228
Bit Score: 1189.31
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 68 R L A K D ASRYSSTIS D pdtnv K QVK V LQ LI N AYR F RGH QH A NL DPL G l WQ Q DKVA DLD PSF H D LT EA D FQET F N VG S F A s G 147
Cdd:PRK12270 370 R W A T D IPADHEDEV D ----- K NAR V ME LI H AYR V RGH LM A DT DPL E - YR Q RSHP DLD VLT H G LT LW D LDRE F P VG G F G - G 442
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 148 KE T MKL GEL L EA L KQT YC GPI G A EYMHI TST E EK RW I Q Q R I E SGRATFNS EE K KR F LS E L T AAE GL E RY L GA K FP G A KRF 227
Cdd:PRK12270 443 KE R MKL RDI L GV L RDS YC RTV G I EYMHI QDP E QR RW L Q E R V E RPHEKPTR EE Q KR I LS K L N AAE AF E TF L QT K YV G Q KRF 522
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 228 SLEGG DA LIP M L KEMIRH A GNS G TR EVV L GMAHRGRLNVL V N VL GK KPQDL F D EF A G KH -- KEHL G T GDVKYH M G FSSD F 305
Cdd:PRK12270 523 SLEGG ES LIP L L DAVLDQ A AEH G LD EVV I GMAHRGRLNVL A N IV GK PYSQI F R EF E G NL dp RSAQ G S GDVKYH L G AEGT F 602
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 306 - Q TD G GLVHLA LA F NPSHLE I V S PV VI G S VRA RL DRLD - EPSSNK VLPI TI HGDAA VT GQGVV Q ETLN M S KA RGY EV GGT 383
Cdd:PRK12270 603 t Q MF G DEIKVS LA A NPSHLE A V D PV LE G I VRA KQ DRLD k GEEGFT VLPI LL HGDAA FA GQGVV A ETLN L S QL RGY RT GGT 682
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 384 VR IV I NNQVGFTT S n P LDA RS TP Y C TD IG KM V QAPIFHVN A DDPEAV AF V T RLA LDF R NT F KR DV F IDLVCYRR H GHNE A 463
Cdd:PRK12270 683 IH IV V NNQVGFTT A - P ESS RS SE Y A TD VA KM I QAPIFHVN G DDPEAV VR V A RLA FEY R QR F HK DV V IDLVCYRR R GHNE G 761
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 464 D E PS A TQPLMY QK I KKHPTP RK I Y ADK L EQEKVA T L E D A TEMVNL Y RDA L DA gdc V VA E W R PMNMHSFTWSPYL nh E W D E 543
Cdd:PRK12270 762 D D PS M TQPLMY DL I DAKRSV RK L Y TEA L IGRGDI T V E E A EQALRD Y QGQ L ER --- V FN E V R EAEKKPPEPPESV -- E S D Q 836
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 544 EY P NK V EMKRLQ E LAK RI S ---- TV PE AVEMQSRVAKIYGD R QA MA A g E KLF DW GGA E N LA YAT L VD EG I PVRLSG E DS G 619
Cdd:PRK12270 837 GP P AG V DTAVSA E VLE RI G dahv NL PE GFTVHPKLKPLLEK R RE MA R - E GGI DW AFG E L LA FGS L LL EG T PVRLSG Q DS R 915
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 620 RGTF FH RHAV IHNQSN G ST YTPLQ HIHNG QG A F R V W DS V LSE E A VLA FEYGY ATAE P RT L TI WEAQFGDFANGAQ VV ID Q 699
Cdd:PRK12270 916 RGTF SQ RHAV LIDRET G EE YTPLQ NLSDD QG K F L V Y DS L LSE Y A AMG FEYGY SVER P DA L VL WEAQFGDFANGAQ TI ID E 995
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 700 FISSGE Q KWG RMC G L V M LLPHGYEGQGP E HSSAR L ER Y LQLCAE Q NM Q V CV PSTPA QVY H M LRRQAL R G M RRPLVV MS PK 779
Cdd:PRK12270 996 FISSGE A KWG QRS G V V L LLPHGYEGQGP D HSSAR I ER F LQLCAE G NM T V AQ PSTPA NYF H L LRRQAL S G P RRPLVV FT PK 1075
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 780 S L LR HPL AVS SL E ELAN G T F L P A I GEIDEL D PKG V K RV VM CSGK V YYDL LEQ R R K NNQH D V AIVR I EQLYP F P HKAMQ E V 859
Cdd:PRK12270 1076 S M LR LKA AVS DV E DFTE G K F R P V I DDPTVD D GAK V R RV LL CSGK L YYDL AAR R E K DGRD D T AIVR V EQLYP L P RAELR E A 1155
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447104217 860 L QQFAHVKDF VW C QEEP L NQGAW YCSQHHFR E VI P F G AS LR YAG RPASASPA V G YMS VH QKQ QQ D L VND A L 930
Cdd:PRK12270 1156 L ARYPNATEV VW V QEEP A NQGAW PFMALNLP E LL P D G RR LR RVS RPASASPA T G SAK VH AVE QQ E L LDE A F 1226
TPP_E1_OGDC_like
cd02016 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed ...
213-474
2.34e-161
Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of the tricarboxylic acid cycle.
Pssm-ID: 238974 [Multi-domain]
Cd Length: 265
Bit Score: 472.78
E-value: 2.34e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 213 L E RY L GA KFPG A KRF S LEG GDA LIP M L K E M I RH A GNS G TR EVV L GMAHRGRLNVL V NVLGK KPQDL F D EF A GK HK -- E H - 289
Cdd:cd02016 1 F E QF L AT KFPG Q KRF G LEG AES LIP A L D E L I DR A AEL G VE EVV I GMAHRGRLNVL A NVLGK PLEQI F S EF E GK SE fp E D d 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 290 L G T GDVKYH M G F SSD FQ T D - G GL VHL A LA F NPSHLE I V S PVV I G SV RA RL D RLDEPSSN KVLPI T IHGDAA VT GQGVV Q E 368
Cdd:cd02016 81 E G S GDVKYH L G Y SSD RK T P s G KK VHL S LA P NPSHLE A V N PVV M G KT RA KQ D YRGDGERD KVLPI L IHGDAA FA GQGVV Y E 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 369 TLN M S KAR GY EV GGT VR IV I NNQ V GFTT s N P L D A RS T PYCTD IG KM VQ APIFHVN A DDPEAV AFV TRLAL DF R NT FK R DV 448
Cdd:cd02016 161 TLN L S NLP GY TT GGT IH IV V NNQ I GFTT - D P R D S RS S PYCTD VA KM IG APIFHVN G DDPEAV VRA TRLAL EY R QK FK K DV 239
250 260
....*....|....*....|....*.
gi 447104217 449 F IDLVCYRRHGHNE A DEPS A TQPLMY 474
Cdd:cd02016 240 V IDLVCYRRHGHNE L DEPS F TQPLMY 265
OxoGdeHyase_C
pfam16870 2-oxoglutarate dehydrogenase C-terminal; OxoGdeHyase_C is a family found immediately ...
788-930
1.88e-78
2-oxoglutarate dehydrogenase C-terminal; OxoGdeHyase_C is a family found immediately C-terminal to Transket_pyr, pfam02779. It is found at the C-terminus of 2-oxoglutarate dehydrogenase.
Pssm-ID: 465289 [Multi-domain]
Cd Length: 147
Bit Score: 251.21
E-value: 1.88e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 788 V SSLEE LAN GT - F LPA I GEIDE L - DP KG VKRVV M CSGKVYYDLL EQ R RKNNQ - H DVAIVRIEQLYPFP HKAMQ E V L QQFA 864
Cdd:pfam16870 1 R SSLEE FTP GT h F QRV I PDPEP L v DP EK VKRVV L CSGKVYYDLL KE R EERGG i K DVAIVRIEQLYPFP FDLLK E E L DKYP 80
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 447104217 865 HVKDF VWCQEEP L NQGAW YCS Q HHFRE V IP - F G AS LRYAGRP A SASPA V G YM SVH QKQ Q QD L VN DA L 930
Cdd:pfam16870 81 NAAEI VWCQEEP K NQGAW SFV Q PRLET V LN e T G HR LRYAGRP P SASPA T G SK SVH LAE Q EA L LD DA F 147
Transket_pyr
pfam02779 Transketolase, pyrimidine binding domain; This family includes transketolase enzymes, pyruvate ...
592-783
2.22e-60
Transketolase, pyrimidine binding domain; This family includes transketolase enzymes, pyruvate dehydrogenases, and branched chain alpha-keto acid decarboxylases.
Pssm-ID: 460692 [Multi-domain]
Cd Length: 174
Bit Score: 203.17
E-value: 2.22e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 592 DWGG A ENL A Y A T L VDEGIP V RLS G E D SGR GTF FHRHAVI H N Q sngstytplqhihngq GA F RV W D SVLS E E A VLA F EY G Y 671
Cdd:pfam02779 4 ATRK A SGE A L A E L AKRDPR V VGG G A D LAG GTF TVTKGLL H P Q ---------------- GA G RV I D TGIA E Q A MVG F AN G M 67
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 672 A TAE P r T L TIW EA Q F G DF A N gaqv VI D QF I SS G EQKWGRMCG - L V MLL P H G YEGQ GP E H S S ARLERY L QLCA eq NMQ V CV 750
Cdd:pfam02779 68 A LHG P - L L PPV EA T F S DF L N ---- RA D DA I RH G AALGKLPVP f V V TRD P I G VGED GP T H Q S VEDLAF L RAIP -- GLK V VR 140
170 180 190
....*....|....*....|....*....|...
gi 447104217 751 PS TP A QVYHM LR RQAL R GM R R P L V VMS P KS LLR 783
Cdd:pfam02779 141 PS DA A ETKGL LR AAIR R DG R K P V V LRL P RQ LLR 173
E1_dh
pfam00676 Dehydrogenase E1 component; This family uses thiamine pyrophosphate as a cofactor. This family ...
225-505
2.39e-42
Dehydrogenase E1 component; This family uses thiamine pyrophosphate as a cofactor. This family includes pyruvate dehydrogenase, 2-oxoglutarate dehydrogenase and 2-oxoisovalerate dehydrogenase.
Pssm-ID: 395548 [Multi-domain]
Cd Length: 300
Bit Score: 156.72
E-value: 2.39e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 225 KRFSLEGGD A LIPMLKEM I RH A GNS G tr EVVL g MAH R GRL N V L VNV L GKK pq DL F D E FA G KHKE hl G T G DVKYHMGFS -- 302
Cdd:pfam00676 21 GIRGFYHLY A GQEAAQVG I AA A LEP G -- DYII - PGY R DHG N L L ARG L SLE -- EI F A E LY G RVAK -- G K G GSMHGYYGA kg 93
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 303 SD F QTDG G LVHL alafnpshlei VS P VVI G SVR A R ld RLDE pss N K VLP IT IH GD A A v TG QG VVQ E T LN MSKARGYE V gg 382
Cdd:pfam00676 94 NR F YGGN G ILGA ----------- QV P LGA G IAL A A -- KYRG --- K K EVA IT LY GD G A - AN QG DFF E G LN FAALWKLP V -- 154
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 383 t VRIVI NNQ V G FT T S n PLD A RSTPYCT D IGKMVQA P IF HV NAD DP E AV AFVTRL A LDFRN T F K RDVF I D LV C YR RH GH NE 462
Cdd:pfam00676 155 - IFVCE NNQ Y G IS T P - AER A SASTTYA D RARGYGI P GL HV DGM DP L AV YQASKF A AERAR T G K GPFL I E LV T YR YG GH SM 232
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 447104217 463 A D E PS ATQ - PLM Y QKIK K HPT P RKIYADK L EQEK V ATL E DATEM 505
Cdd:pfam00676 233 S D D PS TYR t RDE Y EEVR K KKD P IQRFKEH L VSKG V WSE E ELKAI 276
Transket_pyr
smart00861 Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer ...
655-783
4.00e-30
Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer of a two-carbon ketol unit from xylulose 5-phosphate to an aldose receptor, such as ribose 5-phosphate, to form sedoheptulose 7-phosphate and glyceraldehyde 3- phosphate. This enzyme, together with transaldolase, provides a link between the glycolytic and pentose-phosphate pathways. TK requires thiamine pyrophosphate as a cofactor. In most sources where TK has been purified, it is a homodimer of approximately 70 Kd subunits. TK sequences from a variety of eukaryotic and prokaryotic sources show that the enzyme has been evolutionarily conserved. In the peroxisomes of methylotrophic yeast Hansenula polymorpha, there is a highly related enzyme, dihydroxy-acetone synthase (DHAS) (also known as formaldehyde transketolase), which exhibits a very unusual specificity by including formaldehyde amongst its substrates.
Pssm-ID: 214865 [Multi-domain]
Cd Length: 136
Bit Score: 116.05
E-value: 4.00e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 655 W D SVLS E E A VLA F EY G Y A TAE prt L TIWEAQ F GD F ANG A QVV I DQFIS SG E qkwgr MCGLVMLLPH G YE G Q - GP E H S S AR 733
Cdd:smart00861 18 I D TGIA E Q A MVG F AA G L A LHG --- L RPVVEI F FT F FDR A KDQ I RSAGA SG N ----- VPVVFRHDGG G GV G E d GP T H H S IE 89
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 447104217 734 L E - RYLQLC aeq NMQ V CV PS T PA QVYHM LR R q A L R GMRRPLVVMSP KSL L R 783
Cdd:smart00861 90 D E a LLRAIP --- GLK V VA PS D PA EAKGL LR A - A I R DDGPVVIRLER KSL Y R 136
2-oxogl_dehyd_N
pfam16078 2-oxoglutarate dehydrogenase N-terminus; This domain is found at the N-terminus of ...
12-49
7.63e-14
2-oxoglutarate dehydrogenase N-terminus; This domain is found at the N-terminus of 2-oxoglutarate dehydrogenases.
Pssm-ID: 465008 [Multi-domain]
Cd Length: 41
Bit Score: 66.40
E-value: 7.63e-14
10 20 30
....*....|....*....|....*....|....*...
gi 447104217 12 S S Y LSGAN QSW IE Q LYE DF L T DP D SVD AN WR ST F QQ L P 49
Cdd:pfam16078 1 D S F LSGAN AAY IE E LYE QY L K DP S SVD PS WR AY F DN L D 38
TPP_E1_PDC_ADC_BCADC
cd02000 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; ...
352-515
5.50e-08
Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain alpha-keto acid dehydrogenase/2-oxoisovalerate dehydrogenase complex (BCADC). PDC catalyzes the irreversible oxidative decarboxylation of pyruvate to produce acetyl-CoA in the bridging step between glycolysis and the citric acid cycle. ADC participates in the breakdown of acetoin while BCADC participates in the breakdown of branched chain amino acids. BCADC catalyzes the oxidative decarboxylation of 4-methyl-2-oxopentanoate, 3-methyl-2-oxopentanoate and 3-methyl-2-oxobutanoate (branched chain 2-oxo acids derived from the transamination of leucine, valine and isoleucine).
Pssm-ID: 238958 [Multi-domain]
Cd Length: 293
Bit Score: 55.58
E-value: 5.50e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 352 ITIH GD A A v T GQ G VVQ E T LN MSKARGYE V ggt VRIVI NN QVGFT T SN pld A R S T P y C T D I GKMVQ A --- P IFH V NAD D PE 428
Cdd:cd02000 130 VCFF GD G A - T NE G DFH E A LN FAALWKLP V --- IFVCE NN GYAIS T PT --- S R Q T A - G T S I ADRAA A ygi P GIR V DGN D VL 201
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 429 AV AFVTRL A LDF - R NT f KRDVF I DL V C YR RH GH NEA D E PS A -- T QPLMYQKI K KH P TP R ki YADK L EQEKVA T L E DATEM 505
Cdd:cd02000 202 AV YEAAKE A VER a R AG - GGPTL I EA V T YR LG GH STS D D PS R yr T KEEVEEWK K RD P IL R -- LRKY L IEAGIL T E E ELAAI 278
170
....*....|
gi 447104217 506 VNLYRDALDA 515
Cdd:cd02000 279 EAEVKAEVEE 288
PTZ00182
PTZ00182 3-methyl-2-oxobutanate dehydrogenase; Provisional
650-804
2.16e-06
3-methyl-2-oxobutanate dehydrogenase; Provisional
Pssm-ID: 185502 [Multi-domain]
Cd Length: 355
Bit Score: 50.75
E-value: 2.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 650 G AF RV W D SVLS E EAVLA F EY G Y A TAEP R tl T I W E AQ F G DF ANG A qvv I DQ --------- FI S S G EQK wgrm C GL V MLL P H 720
Cdd:PTZ00182 80 G PD RV F D TPIT E QGFAG F AI G A A MNGL R -- P I A E FM F A DF IFP A --- F DQ ivneaakyr YM S G G QFD ---- C PI V IRG P N 150
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447104217 721 G YE G Q - G PE HS S a RL E R Y LQLCA eq NMQ V CV PS T P AQVYHM L r RQ A L R G m RR P L V VMS PK S L L R hplav S S L E ELANGTF 799
Cdd:PTZ00182 151 G AV G H g G AY HS Q - SF E A Y FAHVP -- GLK V VA PS D P EDAKGL L - KA A I R D - PN P V V FFE PK L L Y R ----- E S V E VVPEADY 220
....*
gi 447104217 800 LPAI G 804
Cdd:PTZ00182 221 TLPL G 225
kgd
PRK12270 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
17-55
4.08e-04
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;
Pssm-ID: 237030 [Multi-domain]
Cd Length: 1228
Bit Score: 44.50
E-value: 4.08e-04
10 20 30 40
....*....|....*....|....*....|....*....|
gi 447104217 17 G A N QSWI E QL Y EDF L T DP D SVD AN WR ST F QQL - PG TGVK P 55
Cdd:PRK12270 5 G Q N EWLV E EM Y QQY L A DP N SVD PS WR EF F ADY g PG STAA P 44
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
