|
Name |
Accession |
Description |
Interval |
E-value |
| MSCRAMM_SdrD |
NF012181 |
MSCRAMM family adhesin SdrD; Features of this protein family include a YSIRK-type signal ... |
1-1385 |
0e+00 |
|
MSCRAMM family adhesin SdrD; Features of this protein family include a YSIRK-type signal peptide at the N-terminus and a variable-length C-terminal region of Ser-Asp (SD) repeats followed by an LPXTG motif for surface immobilization by sortase.
Pssm-ID: 467951 [Multi-domain] Cd Length: 1379 Bit Score: 1725.43 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 1 MLNRENKTAITRKGMVSNRLNKFSIRKYTVGTASILVGTTLIFGLGNQEAKAAESTNKELNEATTSASDNQSSDKVDMQQ 80
Cdd:NF012181 1 MLNRENKTAITRKGMVSNRLNKFSIRKYTVGTASILVGTTLIFGLGNQEAKAAESTNKELNEATTSASDNQSSSKVDNQQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 81 LNQEDNTKNDNQKEMVSSQGNETTSNGNKSIEKESVQSTTGNKVEVSTAKSDEQASPKSTNEDLNTKQTISNQEGLQPDL 160
Cdd:NF012181 81 LNQEDNTKNDNQKEMVSSQGNETTSNGNKSIEKESVQSTTGNKVEVSTAKSDEQASPKSTNEDLNTKQTISNQEALQPDL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 161 LENKSVVNVQPTNEENKKVDAKTESTTLNVKSDAIKSNAETLVDNNSNSNNENNADIILPKSTAPKSLNTRMRMAAIQPN 240
Cdd:NF012181 161 QENKSVVNVQPTNEENKKVDAKTESTTLNVKSDAIKSNAETLVDNNSNSNNENNADIILPKSTAPKRLNTRMRMAAVQPS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 241 STDSKNVNDLITSNTTLTVVDADNSKTIVPAQDYLSLKSQITVDDKVKSGDYFTIKYSDTVQVYGLNPEDIKNIGDIKDP 320
Cdd:NF012181 241 STDSKNVNDLITSNTTLTVVDADKNNKIVPAQDYLSLKSQITVDDKVKSGDYFTIKYSDTVQVYGLNPEDIKNIGDIKDP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 321 NNGETIATVKHDTANNLITYTFTDYVDRFNSVKMGINYSIYMDADTIPVDKKDVPFSVTIGNQITTTTADITYPAYKEAD 400
Cdd:NF012181 321 NNGETIATAKHDTANNLITYTFTDYVDRFNSVQMGINYSIYMDADTIPVSKNDVEFNVTIGNTTTKTTANIQYPDYVSRD 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 401 NNSIGSAFTETVSHVGNVEDPGYYNQVVYVNPMDKDLKGAKLKVEAYHPKYPTNIGQINQNVTNIKIYRVPEGYTLNKGY 480
Cdd:NF012181 401 NNSIGSAFTETVSHAGNAEDPGYYKQTVYVNPSEKSLTNAKLKVEAYHKDYPDNVGQINKDVTKIKIYQAPKDYVLNKGY 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 481 DVNTNDLVDVTDEFKNKMTYGSNQSVNLDFGDITSAYVVMVNTKFQYTNSESPTLVQMATLSSTGNKSVSTGNALGFTNN 560
Cdd:NF012181 481 DVNTNQLIDVTEQFKDKITYGANDSVNVDFGSINNSYVVMVDTKFEYTTSESPTLVQMATLSSDGNKSVSTGNALGFTNN 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 561 QSGGAGQEVYKIGNYVWEDTNKNGVQELGEKGVGNVTVTVFDNNTNTKVGEAVTKEDGSYLIPNLPNGDYRVEFSNLPKG 640
Cdd:NF012181 561 QSGGAGQEVYKIGNYVWEDTNKNGVQELGEVGVKGVTVVVYDNKTNKEVGRTITDEKGGYLIPNLPNGDYRVEFSNLPQG 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 641 YEVTPSKQGNNEELDSNGLSSVITVNGKDNLSADLGIYKPKYNLGDYVWEDTNKNGIQDQDEKGISGVTVTLKDENGNVL 720
Cdd:NF012181 641 YEVTPSKQGNNEELDSNGVSSVITVNGKDNLSADLGIYKPKYNLGDYVWEDTNKNGIQDQDEKGISGVTVTLKDENGNVL 720
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 721 KTVTTDADGKYKFTDLDNGNYKVEFTTPEGYTPTTVTSGSDIEKDSNGLTTTGVINGADNMTLDSGFYKTPKYNLGNYVW 800
Cdd:NF012181 721 KTVTTDADGKYKFTDLDNGNYKVEFTTPEGYTPTTVTSGSDIEKDSNGLTTTGVINGADNMTLDSGFYKTPKYNLGNYVW 800
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 801 EDTNKDGKQDSTEKGISGVTVTLKNENGEVLQTTKTDKDGKYQFTGLENGTYKVEFETPSGYTPTQVGSGTDEGIDSNGT 880
Cdd:NF012181 801 EDTNKDGKQDSTEKGISGVTVTLKNENGEVLQTTKTDKDGKYQFTGLENGTYKVEFETPSGYTPTQVGSGTDEGIDSNGT 880
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 881 STTGVIKDKDNDTIDSGFYKPTYNLGDYVWEDTNKNGVQDKDEKGISGVTVTLKDENDKVLKTVTTDENGKYQFTDLNNG 960
Cdd:NF012181 881 STTGVIKDKDNDTIDSGFYKPTYNLGDYVWEDTNKNGVQDKDEKGISGVTVTLKDENDKVLKTVTTDENGKYQFTDLNNG 960
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 961 TYKVEFETPSGYTPTSVTSGNDTEKDSNGLTTTGVIKDADNMTLDSGFYKTPKYSLGDYVWYDSNKDGKQDSTEKGIKDV 1040
Cdd:NF012181 961 TYKVEFETPSGYTPTSVTSGNDTEKDSNGLTTTGVIKDADNMTLDSGFYKTPKYSLGDYVWYDSNKDGKQDSTEKGIKDV 1040
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 1041 KVILLNEKGEVIGTTKTDENGKYRFDNLDSGKYKVIFEKPTGLTQTGTNTTEDDKDADGGEVDVTITDHDDFTLDNGYYE 1120
Cdd:NF012181 1041 KVTLLNEKGEVIGTTKTDENGKYRFDNLDSGKYKVIFEKPAGLTQTGTNTTEDDKDADGGEVDVTITDHDDFTLDNGYFE 1120
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 1121 EETsdsdsdSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 1200
Cdd:NF012181 1121 EET------SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 1194
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 1201 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 1280
Cdd:NF012181 1195 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 1274
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 1281 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDAGKHTPVKPMSTTKDHHNKAKALPETGNENSGSNN 1360
Cdd:NF012181 1275 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDAGKHTPVKPMSTTKDHHNKAKALPETGSENNGSNN 1354
|
1370 1380
....*....|....*....|....*
gi 446857215 1361 ATLFGGLFAALGSLLLFGRRKKQNK 1385
Cdd:NF012181 1355 ATLFGGLFAALGSLLLFGRRKKQNK 1379
|
|
| MSCRAMM_SdrC |
NF000535 |
MSCRAMM family adhesin SdrC; Features of this protein family include a YSIRK-type signal ... |
903-1385 |
3.37e-133 |
|
MSCRAMM family adhesin SdrC; Features of this protein family include a YSIRK-type signal peptide at the N-terminus and a variable-length C-terminal region of Ser-Asp (SD) repeats followed by an LPXTG motif for surface immobilization by sortase.
Pssm-ID: 467948 [Multi-domain] Cd Length: 963 Bit Score: 435.03 E-value: 3.37e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 903 YNLGDYVWEDTNKNGVQDKDEKGISGVTVTLKDENDKVLKTVTTDENGKYQFTDLNNGTYKVEFETPSGYTPTSVTSGND 982
Cdd:NF000535 497 YNLGDYVWEDTNKDGKQDANEKGIKGVYVILKDSNGKELDRTTTDENGKYQFTGLSNGTYSVEFSTPAGYTPTTANAGTD 576
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 983 TEKDSNGLTTTGVIKDADNMTLDSGFYKTPKYSLGDYVWYDSNKDGKQDSTEKGIKDVKVILLNEKGEVIGTTKTDENGK 1062
Cdd:NF000535 577 DAVDSDGLTTTGVIKDADNMTLDSGFYKTPKYSLGDYVWYDSNKDGKQDSTEKGIKGVKVTLQNEKGEVIGTTETDENGK 656
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 1063 YRFDNLDSGKYKVIFEKPTGLTQTGTNTTEDDKDADGGEVDVTITDHDDFTLDNGYYEEETSDSDSDSDSDSDSDSDSDS 1142
Cdd:NF000535 657 YRFDNLDSGKYKVIFEKPAGLTQTGTNTTEDDKDADGGEVDVTITDHDDFTLDNGYYEEETSDSDSDSDSDSDSDSDSDS 736
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 1143 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 1222
Cdd:NF000535 737 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 816
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 1223 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 1302
Cdd:NF000535 817 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 896
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 1303 DSDSDSDsdsdsdsdsdsdsdsdAGKHTPVKPMSTTKDHHNKAKALPETGNENSGSNNATLFGGLFAALGSLLLFGRRKK 1382
Cdd:NF000535 897 DSDSDSD----------------AGKHTPAKPMSTVKDHHNKAKALPETGSENNGSNNATLFGGLFAALGSLLLFGRRKK 960
|
...
gi 446857215 1383 QNK 1385
Cdd:NF000535 961 QNK 963
|
|
| SdrD_B |
pfam17210 |
SdrD B-like domain; This family corresponds to the B-like domain from the SdrD protein. This ... |
682-787 |
3.41e-41 |
|
SdrD B-like domain; This family corresponds to the B-like domain from the SdrD protein. This domain has three calcium binding sites within a greek key beta sandwich fold.
Pssm-ID: 435789 [Multi-domain] Cd Length: 112 Bit Score: 146.98 E-value: 3.41e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 682 YNLGDYVWEDTNKNGIQDQDEKGISGVTVTLKDENGNVLKTVTTDADGKYKFTDLDNGNYKVEFTTPEGYTPTTVTSGSD 761
Cdd:pfam17210 1 ASIGDFVWEDANKNGIQDAGEPGISGVTVTLYDANGTVVGTTTTDANGKYLFTNLAPGTYYVEFTAPAGYTFTPQNQGSD 80
|
90 100 110
....*....|....*....|....*....|..
gi 446857215 762 IEKDSNGLTTTGVIN------GADNMTLDSGF 787
Cdd:pfam17210 81 DALDSDADPATGLTAtvtlasGESDLTIDAGL 112
|
|
| MSCRAMM_ClfA |
NF033609 |
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ... |
15-566 |
1.59e-23 |
|
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.
Pssm-ID: 468110 [Multi-domain] Cd Length: 934 Bit Score: 108.46 E-value: 1.59e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 15 MVSNRLNKFSIRKYTVGTASILVGTTLIFGLgnQEAKAAESTNKELNEATTSASDNQSSDKVDMQQLNQEDNTKNDNQKE 94
Cdd:NF033609 1 MNMKKKEKHAIRKKSIGVASVLVGTLIGFGL--LSSKEADASENSVTQSDSASNESKSNDSSSVSAAPKTDDTNVSDTKT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 95 MVSSQGNETTSNGNKSiEKESVQSTTGNKV--------EVSTAKSDEQASPKSTNEDLNTKQTISNQEGLQPDLLENKSV 166
Cdd:NF033609 79 SSNTNNGETSVAQNPA-QQETTQSASTNATteetpvtgEATTTATNQANTPATTQSSNTNAEELVNQTSNETTSNDTNTV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 167 VNVqptNEENKKVDAKTESTTLNVKSDAIKSNAETlvdnNSNSNNENNADIIlpkSTAPKSLNTRMRMAAIQPNSTDSKN 246
Cdd:NF033609 158 SSV---NSPQNSTNAENVSTTQDTSTEATPSNNES----APQSTDASNKDVV---NQAVNTSAPRMRAFSLAAVAADAPA 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 247 VNDLITSNTTLTVVDADNSKTIVPAQ-DYLSLKSQITVDDKVKSGDYFTIKYSDTvqvygLNPEDIKNIGDIKDPNNGET 325
Cdd:NF033609 228 AGTDITNQLTNVTVGIDSGTTVYPHQaGYVKLNYGFSVPNSAVKGDTFKITVPKE-----LNLNGVTSTAKVPPIMAGDQ 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 326 IATVKHDTANNLITYTFTDYVDRFNSVKMGINYSIYMDADTIpVDKKDVPFSVTIGNQITTTTADITYPAYKEADNNSIG 405
Cdd:NF033609 303 VLANGVIDSDGNVIYTFTDYVDTKEDVKATLTMPAYIDPENV-TKTGNVTLTTGIGSTTANKTVLVDYEKYGKFYNLSIK 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 406 SafteTVSHVGNVEDPgyYNQVVYVNPMDKDLKGAKLkVEAYHPKYPTNiGQINQNVTNIKIYRVPEGYTLNKGYDVNTN 485
Cdd:NF033609 382 G----TIDQIDKTNNT--YRQTIYVNPSGDNVIAPVL-TGNLKPNTDSN-ALIDQQNTSIKVYKVDNAADLSESYFVNPE 453
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 486 DLVDVTDEFKNKMTYGSNQSVNLDFGD--ITSAYVVMVNTKFQyTNSESPTLVQMATLSSTGN---KSVSTGNALGFTNN 560
Cdd:NF033609 454 NFEDVTNSVNITFPNPNQYKVEFNTPDdqITTPYIVVVNGHID-PNSKGDLALRSTLYGYNSNiiwRSMSWDNEVAFNNG 532
|
....*.
gi 446857215 561 QSGGAG 566
Cdd:NF033609 533 SGSGDG 538
|
|
| ClfA |
COG4932 |
Clumping factor A-related surface protein, MSCRAMM (microbial surface components recognizing ... |
527-1111 |
1.88e-21 |
|
Clumping factor A-related surface protein, MSCRAMM (microbial surface components recognizing adhesive matrix molecules) family, DEv-IgG fold [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 443959 [Multi-domain] Cd Length: 689 Bit Score: 101.20 E-value: 1.88e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 527 YTNSESPTLVQMATLSSTGNKSVSTGNALGFTNNQSGGAGQEVYKIGNyvwEDTNKNGVQELGEKGVGNVTVTVFDNNTN 606
Cdd:COG4932 5 KGAGTGVGTVIVEGAGSGSLVAVTTGAVLGLALGSTGGTAGSAAAINS---APATGTATGTSAGATAVIVIAAGLTATPT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 607 TKVGEAVTKEDGSYLIPNLPNGDYRVEFSNLPKGYEVTPSKQGNNEELDSNGLSSVITVNGKDNLSADLGIYKPKYNLGD 686
Cdd:COG4932 82 ETASGLGGDATVTTTANVAKVTNGAAANLTVNADGTASNAGTLAKGAETATGNLDGDAGDVTVTAAATDGVNDVDGNGAS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 687 YVWEDTNKNGIQDQDEKGISGVTVTLKDENGNVLKTVTTDADGKYKFTDLDNGNYKVEFTT-PEGYTPTTvtsgsdieKD 765
Cdd:COG4932 162 VTDSVTLKKVDDGDTGKPLPGATFTLYDSDGTLVKTVTTDADGKYTFTDLPPGTYTLTETKaPEGYVLDT--------KD 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 766 SNGLTTTGVINGADNMTLDsgFYKTPKYNLGNYVWEDTNKDgkqdsTEKGISGVTVTLKNENGEVL---QTTKTDKDGKY 842
Cdd:COG4932 234 PTGATITVTVNAGGTVTVT--LKNTPKYTKGSVTVTKTDAD-----TGEPLAGATFTLTDADGNTVvttTVTVTDADGSY 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 843 QFTGLENGTYKV-EFETPSGYTPtqvgsgtdegidsNGTSTTGVIKDKDNDTIDSGFYKPTYNLGDYVWEDTNKNGvqdk 921
Cdd:COG4932 307 TFTDLPPGTYTVtETKAPAGYDL-------------DGEAVKVTITAGQTTTVTVTNGNNEVKTGSVTLTKVDADD---- 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 922 DEKGISGVTVTLKDENDKVLKTVTTDENGKYQFTDLNNGTYKVEF-ETPSGYTPTSVTSGNDTEKDSNGLTTTgvIKDAD 1000
Cdd:COG4932 370 GEAPLAGAEFTLTDADGTVVATITTDADGTASFKGLAPGTYTLTEtKAPEGYTLDSTPITVTVTDGGTGAIDT--ITNER 447
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 1001 NMTLDSGFYKTPKYSLGDYVWYDSNKDGKQDSTEKGIKDVKVillneKGEVIGTTKTDENGKYRFDNLDSGKYKVIFEKP 1080
Cdd:COG4932 448 KKGSVQVTKVDAPLAGATFTLTDADGTVVTLTTDADLAGATF-----EADGKVVTTTDASGKYTFKNLPPGTYTDAGGSA 522
|
570 580 590
....*....|....*....|....*....|.
gi 446857215 1081 TGLTQTGTNTTEDDKDADGGEVDVTITDHDD 1111
Cdd:COG4932 523 TVITDDTDGTVGDEATGTDPEVTVTGKSTTT 553
|
|
| YSIRK_signal |
TIGR01168 |
Gram-positive signal peptide, YSIRK family; Many surface proteins found in Streptococcus, ... |
18-55 |
3.10e-07 |
|
Gram-positive signal peptide, YSIRK family; Many surface proteins found in Streptococcus, Staphylococcus, and related lineages share apparently homologous signal sequences. A motif resembling [YF]SIRKxxxGxxS[VIA] appears at the start of the transmembrane domain. The GxxS motif appears perfectly conserved, suggesting a specific function and not just homology. There is a strong correlation between proteins carrying this region at the N-terminus and those carrying the Gram-positive anchor domain with the LPXTG sortase processing site at the C-terminus.
Pssm-ID: 273479 [Multi-domain] Cd Length: 39 Bit Score: 47.86 E-value: 3.10e-07
10 20 30
....*....|....*....|....*....|....*...
gi 446857215 18 NRLNKFSIRKYTVGTASILVGtTLIFGLGnqeAKAAES 55
Cdd:TIGR01168 6 EKQQKYSIRKLSVGVASVLVA-SLFFGGG---VAAAES 39
|
|
| Peptidase_M14NE-CP-C_like |
cd11308 |
Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, ... |
918-984 |
8.02e-04 |
|
Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; This domain is found C-terminal to the M14 carboxypeptidase (CP) N/E subfamily containing zinc-binding enzymes that hydrolyze single C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key determinant of specificity. The N/E subfamily includes enzymatically active members (carboxypeptidase N, E, M, D, and Z), as well as non-active members (carboxypeptidase-like protein 1, -2, aortic CP-like protein, and adipocyte enhancer binding protein-1) which lack the critical active site and substrate-binding residues considered necessary for activity. The active N/E enzymes fulfill a variety of cellular functions, including prohormone processing, regulation of peptide hormone activity, alteration of protein-protein or protein-cell interactions and transcriptional regulation. For M14 CPs, it has been suggested that this domain may assist in folding of the CP domain, regulate enzyme activity, or be involved in interactions with other proteins or with membranes; for carboxypeptidase M, it may interact with the bradykinin 1 receptor at the cell surface. This domain may also be found in other peptidase families.
Pssm-ID: 200604 [Multi-domain] Cd Length: 76 Bit Score: 39.43 E-value: 8.02e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446857215 918 VQDKDEKGISGVTVTLKDENdkvlKTVTTDENGKYqFTDLNNGTYKVEFETPsGYTP--TSVTSGNDTE 984
Cdd:cd11308 6 VTDATGNPIANATISVEGIN----HDVTTAKDGDY-WRLLLPGTYNVTASAP-GYQPvtKTVTVPNNFS 68
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MSCRAMM_SdrD |
NF012181 |
MSCRAMM family adhesin SdrD; Features of this protein family include a YSIRK-type signal ... |
1-1385 |
0e+00 |
|
MSCRAMM family adhesin SdrD; Features of this protein family include a YSIRK-type signal peptide at the N-terminus and a variable-length C-terminal region of Ser-Asp (SD) repeats followed by an LPXTG motif for surface immobilization by sortase.
Pssm-ID: 467951 [Multi-domain] Cd Length: 1379 Bit Score: 1725.43 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 1 MLNRENKTAITRKGMVSNRLNKFSIRKYTVGTASILVGTTLIFGLGNQEAKAAESTNKELNEATTSASDNQSSDKVDMQQ 80
Cdd:NF012181 1 MLNRENKTAITRKGMVSNRLNKFSIRKYTVGTASILVGTTLIFGLGNQEAKAAESTNKELNEATTSASDNQSSSKVDNQQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 81 LNQEDNTKNDNQKEMVSSQGNETTSNGNKSIEKESVQSTTGNKVEVSTAKSDEQASPKSTNEDLNTKQTISNQEGLQPDL 160
Cdd:NF012181 81 LNQEDNTKNDNQKEMVSSQGNETTSNGNKSIEKESVQSTTGNKVEVSTAKSDEQASPKSTNEDLNTKQTISNQEALQPDL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 161 LENKSVVNVQPTNEENKKVDAKTESTTLNVKSDAIKSNAETLVDNNSNSNNENNADIILPKSTAPKSLNTRMRMAAIQPN 240
Cdd:NF012181 161 QENKSVVNVQPTNEENKKVDAKTESTTLNVKSDAIKSNAETLVDNNSNSNNENNADIILPKSTAPKRLNTRMRMAAVQPS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 241 STDSKNVNDLITSNTTLTVVDADNSKTIVPAQDYLSLKSQITVDDKVKSGDYFTIKYSDTVQVYGLNPEDIKNIGDIKDP 320
Cdd:NF012181 241 STDSKNVNDLITSNTTLTVVDADKNNKIVPAQDYLSLKSQITVDDKVKSGDYFTIKYSDTVQVYGLNPEDIKNIGDIKDP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 321 NNGETIATVKHDTANNLITYTFTDYVDRFNSVKMGINYSIYMDADTIPVDKKDVPFSVTIGNQITTTTADITYPAYKEAD 400
Cdd:NF012181 321 NNGETIATAKHDTANNLITYTFTDYVDRFNSVQMGINYSIYMDADTIPVSKNDVEFNVTIGNTTTKTTANIQYPDYVSRD 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 401 NNSIGSAFTETVSHVGNVEDPGYYNQVVYVNPMDKDLKGAKLKVEAYHPKYPTNIGQINQNVTNIKIYRVPEGYTLNKGY 480
Cdd:NF012181 401 NNSIGSAFTETVSHAGNAEDPGYYKQTVYVNPSEKSLTNAKLKVEAYHKDYPDNVGQINKDVTKIKIYQAPKDYVLNKGY 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 481 DVNTNDLVDVTDEFKNKMTYGSNQSVNLDFGDITSAYVVMVNTKFQYTNSESPTLVQMATLSSTGNKSVSTGNALGFTNN 560
Cdd:NF012181 481 DVNTNQLIDVTEQFKDKITYGANDSVNVDFGSINNSYVVMVDTKFEYTTSESPTLVQMATLSSDGNKSVSTGNALGFTNN 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 561 QSGGAGQEVYKIGNYVWEDTNKNGVQELGEKGVGNVTVTVFDNNTNTKVGEAVTKEDGSYLIPNLPNGDYRVEFSNLPKG 640
Cdd:NF012181 561 QSGGAGQEVYKIGNYVWEDTNKNGVQELGEVGVKGVTVVVYDNKTNKEVGRTITDEKGGYLIPNLPNGDYRVEFSNLPQG 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 641 YEVTPSKQGNNEELDSNGLSSVITVNGKDNLSADLGIYKPKYNLGDYVWEDTNKNGIQDQDEKGISGVTVTLKDENGNVL 720
Cdd:NF012181 641 YEVTPSKQGNNEELDSNGVSSVITVNGKDNLSADLGIYKPKYNLGDYVWEDTNKNGIQDQDEKGISGVTVTLKDENGNVL 720
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 721 KTVTTDADGKYKFTDLDNGNYKVEFTTPEGYTPTTVTSGSDIEKDSNGLTTTGVINGADNMTLDSGFYKTPKYNLGNYVW 800
Cdd:NF012181 721 KTVTTDADGKYKFTDLDNGNYKVEFTTPEGYTPTTVTSGSDIEKDSNGLTTTGVINGADNMTLDSGFYKTPKYNLGNYVW 800
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 801 EDTNKDGKQDSTEKGISGVTVTLKNENGEVLQTTKTDKDGKYQFTGLENGTYKVEFETPSGYTPTQVGSGTDEGIDSNGT 880
Cdd:NF012181 801 EDTNKDGKQDSTEKGISGVTVTLKNENGEVLQTTKTDKDGKYQFTGLENGTYKVEFETPSGYTPTQVGSGTDEGIDSNGT 880
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 881 STTGVIKDKDNDTIDSGFYKPTYNLGDYVWEDTNKNGVQDKDEKGISGVTVTLKDENDKVLKTVTTDENGKYQFTDLNNG 960
Cdd:NF012181 881 STTGVIKDKDNDTIDSGFYKPTYNLGDYVWEDTNKNGVQDKDEKGISGVTVTLKDENDKVLKTVTTDENGKYQFTDLNNG 960
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 961 TYKVEFETPSGYTPTSVTSGNDTEKDSNGLTTTGVIKDADNMTLDSGFYKTPKYSLGDYVWYDSNKDGKQDSTEKGIKDV 1040
Cdd:NF012181 961 TYKVEFETPSGYTPTSVTSGNDTEKDSNGLTTTGVIKDADNMTLDSGFYKTPKYSLGDYVWYDSNKDGKQDSTEKGIKDV 1040
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 1041 KVILLNEKGEVIGTTKTDENGKYRFDNLDSGKYKVIFEKPTGLTQTGTNTTEDDKDADGGEVDVTITDHDDFTLDNGYYE 1120
Cdd:NF012181 1041 KVTLLNEKGEVIGTTKTDENGKYRFDNLDSGKYKVIFEKPAGLTQTGTNTTEDDKDADGGEVDVTITDHDDFTLDNGYFE 1120
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 1121 EETsdsdsdSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 1200
Cdd:NF012181 1121 EET------SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 1194
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 1201 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 1280
Cdd:NF012181 1195 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 1274
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 1281 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDAGKHTPVKPMSTTKDHHNKAKALPETGNENSGSNN 1360
Cdd:NF012181 1275 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDAGKHTPVKPMSTTKDHHNKAKALPETGSENNGSNN 1354
|
1370 1380
....*....|....*....|....*
gi 446857215 1361 ATLFGGLFAALGSLLLFGRRKKQNK 1385
Cdd:NF012181 1355 ATLFGGLFAALGSLLLFGRRKKQNK 1379
|
|
| MSCRAMM_SdrC |
NF000535 |
MSCRAMM family adhesin SdrC; Features of this protein family include a YSIRK-type signal ... |
903-1385 |
3.37e-133 |
|
MSCRAMM family adhesin SdrC; Features of this protein family include a YSIRK-type signal peptide at the N-terminus and a variable-length C-terminal region of Ser-Asp (SD) repeats followed by an LPXTG motif for surface immobilization by sortase.
Pssm-ID: 467948 [Multi-domain] Cd Length: 963 Bit Score: 435.03 E-value: 3.37e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 903 YNLGDYVWEDTNKNGVQDKDEKGISGVTVTLKDENDKVLKTVTTDENGKYQFTDLNNGTYKVEFETPSGYTPTSVTSGND 982
Cdd:NF000535 497 YNLGDYVWEDTNKDGKQDANEKGIKGVYVILKDSNGKELDRTTTDENGKYQFTGLSNGTYSVEFSTPAGYTPTTANAGTD 576
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 983 TEKDSNGLTTTGVIKDADNMTLDSGFYKTPKYSLGDYVWYDSNKDGKQDSTEKGIKDVKVILLNEKGEVIGTTKTDENGK 1062
Cdd:NF000535 577 DAVDSDGLTTTGVIKDADNMTLDSGFYKTPKYSLGDYVWYDSNKDGKQDSTEKGIKGVKVTLQNEKGEVIGTTETDENGK 656
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 1063 YRFDNLDSGKYKVIFEKPTGLTQTGTNTTEDDKDADGGEVDVTITDHDDFTLDNGYYEEETSDSDSDSDSDSDSDSDSDS 1142
Cdd:NF000535 657 YRFDNLDSGKYKVIFEKPAGLTQTGTNTTEDDKDADGGEVDVTITDHDDFTLDNGYYEEETSDSDSDSDSDSDSDSDSDS 736
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 1143 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 1222
Cdd:NF000535 737 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 816
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 1223 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 1302
Cdd:NF000535 817 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 896
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 1303 DSDSDSDsdsdsdsdsdsdsdsdAGKHTPVKPMSTTKDHHNKAKALPETGNENSGSNNATLFGGLFAALGSLLLFGRRKK 1382
Cdd:NF000535 897 DSDSDSD----------------AGKHTPAKPMSTVKDHHNKAKALPETGSENNGSNNATLFGGLFAALGSLLLFGRRKK 960
|
...
gi 446857215 1383 QNK 1385
Cdd:NF000535 961 QNK 963
|
|
| SdrD_B |
pfam17210 |
SdrD B-like domain; This family corresponds to the B-like domain from the SdrD protein. This ... |
682-787 |
3.41e-41 |
|
SdrD B-like domain; This family corresponds to the B-like domain from the SdrD protein. This domain has three calcium binding sites within a greek key beta sandwich fold.
Pssm-ID: 435789 [Multi-domain] Cd Length: 112 Bit Score: 146.98 E-value: 3.41e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 682 YNLGDYVWEDTNKNGIQDQDEKGISGVTVTLKDENGNVLKTVTTDADGKYKFTDLDNGNYKVEFTTPEGYTPTTVTSGSD 761
Cdd:pfam17210 1 ASIGDFVWEDANKNGIQDAGEPGISGVTVTLYDANGTVVGTTTTDANGKYLFTNLAPGTYYVEFTAPAGYTFTPQNQGSD 80
|
90 100 110
....*....|....*....|....*....|..
gi 446857215 762 IEKDSNGLTTTGVIN------GADNMTLDSGF 787
Cdd:pfam17210 81 DALDSDADPATGLTAtvtlasGESDLTIDAGL 112
|
|
| SdrD_B |
pfam17210 |
SdrD B-like domain; This family corresponds to the B-like domain from the SdrD protein. This ... |
793-898 |
6.32e-40 |
|
SdrD B-like domain; This family corresponds to the B-like domain from the SdrD protein. This domain has three calcium binding sites within a greek key beta sandwich fold.
Pssm-ID: 435789 [Multi-domain] Cd Length: 112 Bit Score: 143.51 E-value: 6.32e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 793 YNLGNYVWEDTNKDGKQDSTEKGISGVTVTLKNENGEVLQTTKTDKDGKYQFTGLENGTYKVEFETPSGYTPTQVGSGTD 872
Cdd:pfam17210 1 ASIGDFVWEDANKNGIQDAGEPGISGVTVTLYDANGTVVGTTTTDANGKYLFTNLAPGTYYVEFTAPAGYTFTPQNQGSD 80
|
90 100 110
....*....|....*....|....*....|..
gi 446857215 873 EGIDSNGTSTTGVIKD------KDNDTIDSGF 898
Cdd:pfam17210 81 DALDSDADPATGLTATvtlasgESDLTIDAGL 112
|
|
| SdrD_B |
pfam17210 |
SdrD B-like domain; This family corresponds to the B-like domain from the SdrD protein. This ... |
903-1008 |
5.44e-39 |
|
SdrD B-like domain; This family corresponds to the B-like domain from the SdrD protein. This domain has three calcium binding sites within a greek key beta sandwich fold.
Pssm-ID: 435789 [Multi-domain] Cd Length: 112 Bit Score: 140.81 E-value: 5.44e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 903 YNLGDYVWEDTNKNGVQDKDEKGISGVTVTLKDENDKVLKTVTTDENGKYQFTDLNNGTYKVEFETPSGYTPTSVTSGND 982
Cdd:pfam17210 1 ASIGDFVWEDANKNGIQDAGEPGISGVTVTLYDANGTVVGTTTTDANGKYLFTNLAPGTYYVEFTAPAGYTFTPQNQGSD 80
|
90 100 110
....*....|....*....|....*....|..
gi 446857215 983 TEKDSNGLTTTGVIKD------ADNMTLDSGF 1008
Cdd:pfam17210 81 DALDSDADPATGLTATvtlasgESDLTIDAGL 112
|
|
| SdrD_B |
pfam17210 |
SdrD B-like domain; This family corresponds to the B-like domain from the SdrD protein. This ... |
1014-1118 |
7.51e-33 |
|
SdrD B-like domain; This family corresponds to the B-like domain from the SdrD protein. This domain has three calcium binding sites within a greek key beta sandwich fold.
Pssm-ID: 435789 [Multi-domain] Cd Length: 112 Bit Score: 123.48 E-value: 7.51e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 1014 YSLGDYVWYDSNKDGKQDSTEKGIKDVKVILLNEKGEVIGTTKTDENGKYRFDNLDSGKYKVIFEKPTGLTQTGTNTTED 1093
Cdd:pfam17210 1 ASIGDFVWEDANKNGIQDAGEPGISGVTVTLYDANGTVVGTTTTDANGKYLFTNLAPGTYYVEFTAPAGYTFTPQNQGSD 80
|
90 100 110
....*....|....*....|....*....|..
gi 446857215 1094 D-KDADGGEVDVTITD------HDDFTLDNGY 1118
Cdd:pfam17210 81 DaLDSDADPATGLTATvtlasgESDLTIDAGL 112
|
|
| SdrD_B |
pfam17210 |
SdrD B-like domain; This family corresponds to the B-like domain from the SdrD protein. This ... |
570-677 |
8.64e-25 |
|
SdrD B-like domain; This family corresponds to the B-like domain from the SdrD protein. This domain has three calcium binding sites within a greek key beta sandwich fold.
Pssm-ID: 435789 [Multi-domain] Cd Length: 112 Bit Score: 100.37 E-value: 8.64e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 570 YKIGNYVWEDTNKNGVQELGEKGVGNVTVTVFDNNTNTkVGEAVTKEDGSYLIPNLPNGDYRVEFSNlPKGYEVTPSKQG 649
Cdd:pfam17210 1 ASIGDFVWEDANKNGIQDAGEPGISGVTVTLYDANGTV-VGTTTTDANGKYLFTNLAPGTYYVEFTA-PAGYTFTPQNQG 78
|
90 100 110
....*....|....*....|....*....|....
gi 446857215 650 NNEELDSN-----GLSSVITV-NGKDNLSADLGI 677
Cdd:pfam17210 79 SDDALDSDadpatGLTATVTLaSGESDLTIDAGL 112
|
|
| MSCRAMM_ClfA |
NF033609 |
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ... |
15-566 |
1.59e-23 |
|
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.
Pssm-ID: 468110 [Multi-domain] Cd Length: 934 Bit Score: 108.46 E-value: 1.59e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 15 MVSNRLNKFSIRKYTVGTASILVGTTLIFGLgnQEAKAAESTNKELNEATTSASDNQSSDKVDMQQLNQEDNTKNDNQKE 94
Cdd:NF033609 1 MNMKKKEKHAIRKKSIGVASVLVGTLIGFGL--LSSKEADASENSVTQSDSASNESKSNDSSSVSAAPKTDDTNVSDTKT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 95 MVSSQGNETTSNGNKSiEKESVQSTTGNKV--------EVSTAKSDEQASPKSTNEDLNTKQTISNQEGLQPDLLENKSV 166
Cdd:NF033609 79 SSNTNNGETSVAQNPA-QQETTQSASTNATteetpvtgEATTTATNQANTPATTQSSNTNAEELVNQTSNETTSNDTNTV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 167 VNVqptNEENKKVDAKTESTTLNVKSDAIKSNAETlvdnNSNSNNENNADIIlpkSTAPKSLNTRMRMAAIQPNSTDSKN 246
Cdd:NF033609 158 SSV---NSPQNSTNAENVSTTQDTSTEATPSNNES----APQSTDASNKDVV---NQAVNTSAPRMRAFSLAAVAADAPA 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 247 VNDLITSNTTLTVVDADNSKTIVPAQ-DYLSLKSQITVDDKVKSGDYFTIKYSDTvqvygLNPEDIKNIGDIKDPNNGET 325
Cdd:NF033609 228 AGTDITNQLTNVTVGIDSGTTVYPHQaGYVKLNYGFSVPNSAVKGDTFKITVPKE-----LNLNGVTSTAKVPPIMAGDQ 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 326 IATVKHDTANNLITYTFTDYVDRFNSVKMGINYSIYMDADTIpVDKKDVPFSVTIGNQITTTTADITYPAYKEADNNSIG 405
Cdd:NF033609 303 VLANGVIDSDGNVIYTFTDYVDTKEDVKATLTMPAYIDPENV-TKTGNVTLTTGIGSTTANKTVLVDYEKYGKFYNLSIK 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 406 SafteTVSHVGNVEDPgyYNQVVYVNPMDKDLKGAKLkVEAYHPKYPTNiGQINQNVTNIKIYRVPEGYTLNKGYDVNTN 485
Cdd:NF033609 382 G----TIDQIDKTNNT--YRQTIYVNPSGDNVIAPVL-TGNLKPNTDSN-ALIDQQNTSIKVYKVDNAADLSESYFVNPE 453
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 486 DLVDVTDEFKNKMTYGSNQSVNLDFGD--ITSAYVVMVNTKFQyTNSESPTLVQMATLSSTGN---KSVSTGNALGFTNN 560
Cdd:NF033609 454 NFEDVTNSVNITFPNPNQYKVEFNTPDdqITTPYIVVVNGHID-PNSKGDLALRSTLYGYNSNiiwRSMSWDNEVAFNNG 532
|
....*.
gi 446857215 561 QSGGAG 566
Cdd:NF033609 533 SGSGDG 538
|
|
| SdrG_C_C |
pfam10425 |
C-terminus of bacterial fibrinogen-binding adhesin; This is the C-terminal half of a bacterial ... |
411-559 |
6.78e-22 |
|
C-terminus of bacterial fibrinogen-binding adhesin; This is the C-terminal half of a bacterial fibrinogen-binding adhesin SdrG. SdrG is a Gram-positive cell-wall-anchored adhesin that allows attachment of the bacterium to host tissues via specific binding to the beta-chain of human fibrinogen (Fg). SdrG binds to its ligand with a dynamic "dock, lock, and latch" mechanism which represents a general mode of ligand-binding for structurally related cell wall-anchored proteins in most Gram-positive bacteria. The C-terminal part of SdrG(276-596) is integral to the folding of the immunoglobulin-like whole to create the docking grooves necessary for Fg binding. The domain is associated with families of Cna_B, pfam05738.
Pssm-ID: 431277 [Multi-domain] Cd Length: 156 Bit Score: 93.64 E-value: 6.78e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 411 TVSHVGNVEdpGYYNQVVYVNPMDKDLKGAKlkVEAYHPKYPTNIGQINQNVTNIKIYRVPEGYTLNKGYDVNTND--LV 488
Cdd:pfam10425 11 RIMHFDKEN--GTFEQTIYVNPNKKSLTSAT--VTGNLSGYIDSGSKVNPNNTNVKIYKVNDGQDLPDSYYVNEDTseLE 86
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446857215 489 DVTDEFKNKMTYGSNQSVNLDFGDI--TSAYVVMVNTKFQYTNSESPTLVQMATLSSTGNKSVSTgnaLGFTN 559
Cdd:pfam10425 87 DVTNQFDGYISLGNNNSASINFGNLqsDKSYIVKVVGKYDNNNDDSVDLRTTLYGYNTQYVTSYS---YGWTN 156
|
|
| ClfA |
COG4932 |
Clumping factor A-related surface protein, MSCRAMM (microbial surface components recognizing ... |
527-1111 |
1.88e-21 |
|
Clumping factor A-related surface protein, MSCRAMM (microbial surface components recognizing adhesive matrix molecules) family, DEv-IgG fold [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 443959 [Multi-domain] Cd Length: 689 Bit Score: 101.20 E-value: 1.88e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 527 YTNSESPTLVQMATLSSTGNKSVSTGNALGFTNNQSGGAGQEVYKIGNyvwEDTNKNGVQELGEKGVGNVTVTVFDNNTN 606
Cdd:COG4932 5 KGAGTGVGTVIVEGAGSGSLVAVTTGAVLGLALGSTGGTAGSAAAINS---APATGTATGTSAGATAVIVIAAGLTATPT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 607 TKVGEAVTKEDGSYLIPNLPNGDYRVEFSNLPKGYEVTPSKQGNNEELDSNGLSSVITVNGKDNLSADLGIYKPKYNLGD 686
Cdd:COG4932 82 ETASGLGGDATVTTTANVAKVTNGAAANLTVNADGTASNAGTLAKGAETATGNLDGDAGDVTVTAAATDGVNDVDGNGAS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 687 YVWEDTNKNGIQDQDEKGISGVTVTLKDENGNVLKTVTTDADGKYKFTDLDNGNYKVEFTT-PEGYTPTTvtsgsdieKD 765
Cdd:COG4932 162 VTDSVTLKKVDDGDTGKPLPGATFTLYDSDGTLVKTVTTDADGKYTFTDLPPGTYTLTETKaPEGYVLDT--------KD 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 766 SNGLTTTGVINGADNMTLDsgFYKTPKYNLGNYVWEDTNKDgkqdsTEKGISGVTVTLKNENGEVL---QTTKTDKDGKY 842
Cdd:COG4932 234 PTGATITVTVNAGGTVTVT--LKNTPKYTKGSVTVTKTDAD-----TGEPLAGATFTLTDADGNTVvttTVTVTDADGSY 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 843 QFTGLENGTYKV-EFETPSGYTPtqvgsgtdegidsNGTSTTGVIKDKDNDTIDSGFYKPTYNLGDYVWEDTNKNGvqdk 921
Cdd:COG4932 307 TFTDLPPGTYTVtETKAPAGYDL-------------DGEAVKVTITAGQTTTVTVTNGNNEVKTGSVTLTKVDADD---- 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 922 DEKGISGVTVTLKDENDKVLKTVTTDENGKYQFTDLNNGTYKVEF-ETPSGYTPTSVTSGNDTEKDSNGLTTTgvIKDAD 1000
Cdd:COG4932 370 GEAPLAGAEFTLTDADGTVVATITTDADGTASFKGLAPGTYTLTEtKAPEGYTLDSTPITVTVTDGGTGAIDT--ITNER 447
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 1001 NMTLDSGFYKTPKYSLGDYVWYDSNKDGKQDSTEKGIKDVKVillneKGEVIGTTKTDENGKYRFDNLDSGKYKVIFEKP 1080
Cdd:COG4932 448 KKGSVQVTKVDAPLAGATFTLTDADGTVVTLTTDADLAGATF-----EADGKVVTTTDASGKYTFKNLPPGTYTDAGGSA 522
|
570 580 590
....*....|....*....|....*....|.
gi 446857215 1081 TGLTQTGTNTTEDDKDADGGEVDVTITDHDD 1111
Cdd:COG4932 523 TVITDDTDGTVGDEATGTDPEVTVTGKSTTT 553
|
|
| Big_8 |
pfam17961 |
Bacterial Ig domain; This entry represents a bacterial Ig-fold domain that is found in a wide ... |
269-372 |
1.11e-20 |
|
Bacterial Ig domain; This entry represents a bacterial Ig-fold domain that is found in a wide range of bacterial cell surface adherence proteins.
Pssm-ID: 465589 [Multi-domain] Cd Length: 102 Bit Score: 88.05 E-value: 1.11e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 269 VPAQDYLSLKSQITVDDKVKSGDYFTIKYSDTVQVYGLNPEDIknIGDIKDPNnGETIATVKHDTANNLITYTFTDYVDR 348
Cdd:pfam17961 2 PDQGESLKLKADFSLGDSVKEGDYFTIKLPDNLKFYGINTSDK--SFDIKDDN-GEVIAKGTYDPGTGTITYTFTDYVEN 78
|
90 100
....*....|....*....|....
gi 446857215 349 FNSVKMGINYSIYMDADTIPVDKK 372
Cdd:pfam17961 79 KSNIKGSLYLPAYIDKKKVKENGK 102
|
|
| ClfA |
COG4932 |
Clumping factor A-related surface protein, MSCRAMM (microbial surface components recognizing ... |
458-1113 |
4.80e-15 |
|
Clumping factor A-related surface protein, MSCRAMM (microbial surface components recognizing adhesive matrix molecules) family, DEv-IgG fold [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 443959 [Multi-domain] Cd Length: 689 Bit Score: 80.40 E-value: 4.80e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 458 INQNVTNIKIYRVPEGYTLNKGYDVNTNDLVDVTDEFKNKMTYGSNQSVNLDFGDITSAYVVMVNTKFQYTNSESPTLVQ 537
Cdd:COG4932 13 TVIVEGAGSGSLVAVTTGAVLGLALGSTGGTAGSAAAINSAPATGTATGTSAGATAVIVIAAGLTATPTETASGLGGDAT 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 538 MATLSSTGNKSVSTGNALGFTNNQSGGAGQEVYKIGNYVWEDTNKNGVQELGEKGVGNVTVTVFDNNTNTKVGEAVTKED 617
Cdd:COG4932 93 VTTTANVAKVTNGAAANLTVNADGTASNAGTLAKGAETATGNLDGDAGDVTVTAAATDGVNDVDGNGASVTDSVTLKKVD 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 618 GSYLIPNLPNGDYRVEFSNLPKGYEVTPSKQGNNE-----------------------ELDSNGLSSVITVNGKDNLSAD 674
Cdd:COG4932 173 DGDTGKPLPGATFTLYDSDGTLVKTVTTDADGKYTftdlppgtytltetkapegyvldTKDPTGATITVTVNAGGTVTVT 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 675 LGIyKPKYNLGDYVWEDTNKNGiqdqdEKGISGVTVTLKDENGNVL---KTVTTDADGKYKFTDLDNGNYKVEFTT-PEG 750
Cdd:COG4932 253 LKN-TPKYTKGSVTVTKTDADT-----GEPLAGATFTLTDADGNTVvttTVTVTDADGSYTFTDLPPGTYTVTETKaPAG 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 751 YTPttvtsgsdiekDSNGLTTTGVINGADNMTLDSGFYKTPKYNLgnyvwedTNKDGKQDSTEKGISGVTVTLKNENGEV 830
Cdd:COG4932 327 YDL-----------DGEAVKVTITAGQTTTVTVTNGNNEVKTGSV-------TLTKVDADDGEAPLAGAEFTLTDADGTV 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 831 LQTTKTDKDGKYQFTGLENGTYKVEF-ETPSGYTPTqvGSGTDEGIDSNGTSTTGVIKDKdNDTIDSGFYKPTYNLGDYV 909
Cdd:COG4932 389 VATITTDADGTASFKGLAPGTYTLTEtKAPEGYTLD--STPITVTVTDGGTGAIDTITNE-RKKGSVQVTKVDAPLAGAT 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 910 WEDTNKNGVQDKDEKGISGVTVTLKDENDKVlktVTTDENGKYQFTDLNNGTYKVEFETPSGYTPTSVTSGNDTEKDSNG 989
Cdd:COG4932 466 FTLTDADGTVVTLTTDADLAGATFEADGKVV---TTTDASGKYTFKNLPPGTYTDAGGSATVITDDTDGTVGDEATGTDP 542
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 990 LTTTGVIKD--ADNMTLDSGFYKTPKYSLGDYVWYDSNKDGKQDSTEKGIKDVKVILLNEKGEVIGTTKTDENGKYRFDN 1067
Cdd:COG4932 543 EVTVTGKSTttTPDVALLTNLGTTEDALTSLAKTGDEVGKGLTLTTTTTVDTLDTNATEKTETVTVTAQLIGVKTTKLTD 622
|
650 660 670 680
....*....|....*....|....*....|....*....|....*.
gi 446857215 1068 LDSGKYKVIFEKPTGLTQTGTNTTEDDKDADGGEVDVTITDHDDFT 1113
Cdd:COG4932 623 TTDPKGGTVEEATTTGGTANTGKTGTDLTDDTTVTSTTNTATSVED 668
|
|
| CarboxypepD_reg |
pfam13620 |
Carboxypeptidase regulatory-like domain; |
697-758 |
2.35e-09 |
|
Carboxypeptidase regulatory-like domain;
Pssm-ID: 433354 [Multi-domain] Cd Length: 81 Bit Score: 55.36 E-value: 2.35e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446857215 697 IQDQDEKGISGVTVTLKDENGNVLKTVTTDADGKYKFTDLDNGNYKVEFTTPeGYTPTTVTS 758
Cdd:pfam13620 6 VTDPSGAPVPGATVTVTNTDTGTVRTTTTDADGRYRFPGLPPGTYTVTVSAP-GFKTATRTG 66
|
|
| CarboxypepD_reg |
pfam13620 |
Carboxypeptidase regulatory-like domain; |
810-867 |
4.85e-09 |
|
Carboxypeptidase regulatory-like domain;
Pssm-ID: 433354 [Multi-domain] Cd Length: 81 Bit Score: 54.21 E-value: 4.85e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 446857215 810 DSTEKGISGVTVTLKNENGEVLQTTKTDKDGKYQFTGLENGTYKVEFETPsGYTPTQV 867
Cdd:pfam13620 8 DPSGAPVPGATVTVTNTDTGTVRTTTTDADGRYRFPGLPPGTYTVTVSAP-GFKTATR 64
|
|
| CarboxypepD_reg |
pfam13620 |
Carboxypeptidase regulatory-like domain; |
918-979 |
6.13e-09 |
|
Carboxypeptidase regulatory-like domain;
Pssm-ID: 433354 [Multi-domain] Cd Length: 81 Bit Score: 54.21 E-value: 6.13e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446857215 918 VQDKDEKGISGVTVTLKDENDKVLKTVTTDENGKYQFTDLNNGTYKVEFETPsGYTPTSVTS 979
Cdd:pfam13620 6 VTDPSGAPVPGATVTVTNTDTGTVRTTTTDADGRYRFPGLPPGTYTVTVSAP-GFKTATRTG 66
|
|
| YSIRK_signal |
pfam04650 |
YSIRK type signal peptide; Many surface proteins found in Streptococcus, Staphylococcus, and ... |
18-43 |
1.68e-08 |
|
YSIRK type signal peptide; Many surface proteins found in Streptococcus, Staphylococcus, and related lineages share apparently homologous signal sequences. A motif resembling [YF]SIRKxxxGxxS[VIA] appears at the start of the transmembrane domain. The GxxS motif appears perfectly conserved, suggesting a specific function and not just homology. There is a strong correlation between proteins carrying this region at the N-terminus and those carrying the Gram-positive anchor domain with the LPXTG sortase processing site at the C-terminus.
Pssm-ID: 428049 [Multi-domain] Cd Length: 26 Bit Score: 51.23 E-value: 1.68e-08
|
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
593-978 |
8.84e-08 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 57.01 E-value: 8.84e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 593 VGNVTVTVFDNNtNTKVGEAVTKEDGSYLIPNLPNGDYRVE-------------FSNLPKGYEVTPSKQGNNEELDSNGL 659
Cdd:COG2373 291 VAGAEVELYDRN-GQVLATATTDADGLARFPAGDRGEGGRApallvarkggdfaFLDLDDGPALDLSDFDVGGRAPPGGL 369
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 660 SSVITvngkdnlsADLGIYKPkynlGDYVWedtnKNGI-QDQDEKGISG--VTVTLKDENGNVLK--TVTTDADGKYKFT 734
Cdd:COG2373 370 DAFLF--------TDRGIYRP----GETVH----LKALlRDADGKAPAGlpLTLELTDPDGKEVRrqTLTLNEFGGYSFS 433
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 735 -----DLDNGNYKVEFTTPEGYTPTT--------------VTSGSDIEKDSNGLTTTGVING-------ADNMTLDSGFY 788
Cdd:COG2373 434 fplpeDAPTGTWRLELYVDPKPALGSksfrveefkpprfkVDLTLDKEPLKPGDPVTVTVDArylfgapAAGLKVEGEVT 513
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 789 KTPKYN----LGNYVWEDTNKDGKQDSTEkgisgvtvtlknengevLQTTKTDKDGKYQFT------GLENGTYKVEFET 858
Cdd:COG2373 514 LRPARTafpgYPGYRFGDPDEEFEPEELD-----------------LGEGTLDADGKASLSlplpdaPDAPGPLRATVEA 576
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 859 ----PSGYT------------PTQVG--SGTDEGIDSNGTSTTGVI------KDKDNDTIDSGFYKPTYnlgDYVWEDTN 914
Cdd:COG2373 577 svfeSGGRPvtrsatvpvhpaDFYVGirLPLFDGDPEGAPATFEVVavdpdgKPVAGKGLKVELYREEW---RYVWYKSD 653
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446857215 915 KNGVQDKDEKgisgVTVTLKDendkvlKTVTTDENG--KYQFTDLNNGTYKVEFETPSGYTPTSVT 978
Cdd:COG2373 654 DGGWRYESQE----KEEPVAE------GTLTTGADGpaSLSLTPVEWGRYRLEVKDPDGGLATSVR 709
|
|
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
816-1066 |
1.27e-07 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 56.63 E-value: 1.27e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 816 ISGVTVTLKNENGEVLQTTKTDKDGKYQFTGLENGT-------YKVEFETPSGYTPTQVGSGTDegidsngTSTTGVIKD 888
Cdd:COG2373 291 VAGAEVELYDRNGQVLATATTDADGLARFPAGDRGEggrapalLVARKGGDFAFLDLDDGPALD-------LSDFDVGGR 363
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 889 KDNDTIDS------GFYKPtynlGDYVWedtnKNG-VQDKDEKGISG--VTVTLKDENDKVLK--TVTTDENGKYQFT-- 955
Cdd:COG2373 364 APPGGLDAflftdrGIYRP----GETVH----LKAlLRDADGKAPAGlpLTLELTDPDGKEVRrqTLTLNEFGGYSFSfp 435
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 956 ---DLNNGTYKVEFETPSGYTPTS--------------VTSGNDTEKDSNGLTTTGVIkDADN--------------MTL 1004
Cdd:COG2373 436 lpeDAPTGTWRLELYVDPKPALGSksfrveefkpprfkVDLTLDKEPLKPGDPVTVTV-DARYlfgapaaglkvegeVTL 514
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446857215 1005 DSGFYKTPKYSlgDYVWYDSNKDGKQDSTEkgikdvkvillnekgevIGTTKTDENGKYRFD 1066
Cdd:COG2373 515 RPARTAFPGYP--GYRFGDPDEEFEPEELD-----------------LGEGTLDADGKASLS 557
|
|
| YSIRK_signal |
TIGR01168 |
Gram-positive signal peptide, YSIRK family; Many surface proteins found in Streptococcus, ... |
18-55 |
3.10e-07 |
|
Gram-positive signal peptide, YSIRK family; Many surface proteins found in Streptococcus, Staphylococcus, and related lineages share apparently homologous signal sequences. A motif resembling [YF]SIRKxxxGxxS[VIA] appears at the start of the transmembrane domain. The GxxS motif appears perfectly conserved, suggesting a specific function and not just homology. There is a strong correlation between proteins carrying this region at the N-terminus and those carrying the Gram-positive anchor domain with the LPXTG sortase processing site at the C-terminus.
Pssm-ID: 273479 [Multi-domain] Cd Length: 39 Bit Score: 47.86 E-value: 3.10e-07
10 20 30
....*....|....*....|....*....|....*...
gi 446857215 18 NRLNKFSIRKYTVGTASILVGtTLIFGLGnqeAKAAES 55
Cdd:TIGR01168 6 EKQQKYSIRKLSVGVASVLVA-SLFFGGG---VAAAES 39
|
|
| CarboxypepD_reg |
pfam13620 |
Carboxypeptidase regulatory-like domain; |
1031-1107 |
4.35e-07 |
|
Carboxypeptidase regulatory-like domain;
Pssm-ID: 433354 [Multi-domain] Cd Length: 81 Bit Score: 48.82 E-value: 4.35e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446857215 1031 DSTEKGIKDVKVILLNEKGEVIGTTKTDENGKYRFDNLDSGKYKVIFEKPTGLTQTGTNTTEDdkdaDGGEVDVTIT 1107
Cdd:pfam13620 8 DPSGAPVPGATVTVTNTDTGTVRTTTTDADGRYRFPGLPPGTYTVTVSAPGFKTATRTGVTVT----AGQTTTLDVT 80
|
|
| ClfA |
COG4932 |
Clumping factor A-related surface protein, MSCRAMM (microbial surface components recognizing ... |
744-1079 |
4.36e-07 |
|
Clumping factor A-related surface protein, MSCRAMM (microbial surface components recognizing adhesive matrix molecules) family, DEv-IgG fold [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 443959 [Multi-domain] Cd Length: 689 Bit Score: 54.59 E-value: 4.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 744 EFTTPEGYTPTTVTSGSDIEKDSNGLTTTGVINGADNMTLDSGFYKTPKYNLGNYVWEDTNKDGKQDSTEKGISGVTVTl 823
Cdd:COG4932 1 SVGAKGAGTGVGTVIVEGAGSGSLVAVTTGAVLGLALGSTGGTAGSAAAINSAPATGTATGTSAGATAVIVIAAGLTAT- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 824 knENGEVLQTTKTDKDGKYQFTGLENGTYKVEFETPSGYTPTQVGSGTDEGIDSNGTSTTGVIKDKDNDTIDSGFYKPTY 903
Cdd:COG4932 80 --PTETASGLGGDATVTTTANVAKVTNGAAANLTVNADGTASNAGTLAKGAETATGNLDGDAGDVTVTAAATDGVNDVDG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 904 NLGDYVWEDTNKNGVQDKDEKGISGVTVTLKDENDKVLKTVTTDENGKYQFTDLNNGTYKV-EFETPSGYTPTsvtsgnd 982
Cdd:COG4932 158 NGASVTDSVTLKKVDDGDTGKPLPGATFTLYDSDGTLVKTVTTDADGKYTFTDLPPGTYTLtETKAPEGYVLD------- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 983 tekDSNGLTTTGVIKDADNMTLDSGFYKTPKYSLGDYVWYDSNKDgkqdsTEKGIKDVKVILLNEKGEVIGT---TKTDE 1059
Cdd:COG4932 231 ---TKDPTGATITVTVNAGGTVTVTLKNTPKYTKGSVTVTKTDAD-----TGEPLAGATFTLTDADGNTVVTttvTVTDA 302
|
330 340
....*....|....*....|
gi 446857215 1060 NGKYRFDNLDSGKYKVIFEK 1079
Cdd:COG4932 303 DGSYTFTDLPPGTYTVTETK 322
|
|
| Gram_pos_anchor |
pfam00746 |
LPXTG cell wall anchor motif; |
1340-1385 |
1.59e-06 |
|
LPXTG cell wall anchor motif;
Pssm-ID: 366278 [Multi-domain] Cd Length: 43 Bit Score: 45.99 E-value: 1.59e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 446857215 1340 DHHNKAKALPETGNEnsgSNNATLFGGLFAALGSLLLFGRRKKQNK 1385
Cdd:pfam00746 1 AKKSKKKTLPKTGEN---SNIFLTAAGLLALLGGLLLLVKRRKKEK 43
|
|
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
705-1105 |
1.92e-06 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 52.78 E-value: 1.92e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 705 ISGVTVTLKDENGNVLKTVTTDADGKYKFTDLDNGnykvefttPEGYTPT--TVTSGSDIekdsngltttGVINGADNMT 782
Cdd:COG2373 291 VAGAEVELYDRNGQVLATATTDADGLARFPAGDRG--------EGGRAPAllVARKGGDF----------AFLDLDDGPA 352
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 783 LD-SGFY---KTPKYNLGNYVWED----------------TNKDGKQDsteKGISgVTVTLKNENGEVL--QTTKTDKDG 840
Cdd:COG2373 353 LDlSDFDvggRAPPGGLDAFLFTDrgiyrpgetvhlkallRDADGKAP---AGLP-LTLELTDPDGKEVrrQTLTLNEFG 428
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 841 KYQFT-----GLENGTYKVEFETPSGytpTQVGSGT--------DEgIDSNGTSTTGVIKDKDNDTID-----------S 896
Cdd:COG2373 429 GYSFSfplpeDAPTGTWRLELYVDPK---PALGSKSfrveefkpPR-FKVDLTLDKEPLKPGDPVTVTvdarylfgapaA 504
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 897 G-------FYKPTYN----LGDYVWEDTNKNGvqdkdekgiSGVTVTLKDendkvlktVTTDENGKYQFT-DLNN----- 959
Cdd:COG2373 505 GlkvegevTLRPARTafpgYPGYRFGDPDEEF---------EPEELDLGE--------GTLDADGKASLSlPLPDapdap 567
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 960 GTYKVEFET----PSGYTPTSVTS----------------GNDTEKDSN------GLTTTGVIKDADNMTLDsgFYKTpK 1013
Cdd:COG2373 568 GPLRATVEAsvfeSGGRPVTRSATvpvhpadfyvgirlplFDGDPEGAPatfevvAVDPDGKPVAGKGLKVE--LYRE-E 644
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 1014 YslgDYVWYDSNKDGKQDSTEKgiKDVKVillnEKGEVigTTKTDENGKYRFDNLDSGKYKVIFEKPTGLTQTGTNT--- 1090
Cdd:COG2373 645 W---RYVWYKSDDGGWRYESQE--KEEPV----AEGTL--TTGADGPASLSLTPVEWGRYRLEVKDPDGGLATSVRFyag 713
|
490
....*....|....*.
gi 446857215 1091 -TEDDKDADGGEVDVT 1105
Cdd:COG2373 714 gNASWGAERPDRLELS 729
|
|
| SpaA |
pfam17802 |
Prealbumin-like fold domain; This entry contains a prealbumin-like domain from a wide variety ... |
700-755 |
5.35e-06 |
|
Prealbumin-like fold domain; This entry contains a prealbumin-like domain from a wide variety of bacterial surface proteins. This entry corresponds to domain 1 and domain 3 of SpaA from Corynebacterium diphtheriae. Some members of this family contain an isopeptide bond.
Pssm-ID: 465513 [Multi-domain] Cd Length: 72 Bit Score: 45.27 E-value: 5.35e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446857215 700 QDEKGISGVTVTLKDEN----GNVLKTVTTDADGKYKFTDLDNGNYKV-EFTTPEGYTPTT 755
Cdd:pfam17802 1 DTGKPLAGAEFTLYDADgtvdGKVVGTLTTDEDGKATFDGLPPGTYTLkETKAPDGYVLDD 61
|
|
| SpaA |
pfam17802 |
Prealbumin-like fold domain; This entry contains a prealbumin-like domain from a wide variety ... |
921-976 |
1.45e-05 |
|
Prealbumin-like fold domain; This entry contains a prealbumin-like domain from a wide variety of bacterial surface proteins. This entry corresponds to domain 1 and domain 3 of SpaA from Corynebacterium diphtheriae. Some members of this family contain an isopeptide bond.
Pssm-ID: 465513 [Multi-domain] Cd Length: 72 Bit Score: 44.11 E-value: 1.45e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446857215 921 KDEKGISGVTVTLKDEND----KVLKTVTTDENGKYQFTDLNNGTYKV-EFETPSGYTPTS 976
Cdd:pfam17802 1 DTGKPLAGAEFTLYDADGtvdgKVVGTLTTDEDGKATFDGLPPGTYTLkETKAPDGYVLDD 61
|
|
| CarboxypepD_reg |
pfam13620 |
Carboxypeptidase regulatory-like domain; |
593-635 |
3.42e-05 |
|
Carboxypeptidase regulatory-like domain;
Pssm-ID: 433354 [Multi-domain] Cd Length: 81 Bit Score: 43.42 E-value: 3.42e-05
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 446857215 593 VGNVTVTVFDNNTNTKVGeAVTKEDGSYLIPNLPNGDYRVEFS 635
Cdd:pfam13620 14 VPGATVTVTNTDTGTVRT-TTTDADGRYRFPGLPPGTYTVTVS 55
|
|
| SpaA |
pfam17802 |
Prealbumin-like fold domain; This entry contains a prealbumin-like domain from a wide variety ... |
812-866 |
2.45e-04 |
|
Prealbumin-like fold domain; This entry contains a prealbumin-like domain from a wide variety of bacterial surface proteins. This entry corresponds to domain 1 and domain 3 of SpaA from Corynebacterium diphtheriae. Some members of this family contain an isopeptide bond.
Pssm-ID: 465513 [Multi-domain] Cd Length: 72 Bit Score: 40.65 E-value: 2.45e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446857215 812 TEKGISGVTVTLKNEN----GEVLQTTKTDKDGKYQFTGLENGTYKV-EFETPSGYTPTQ 866
Cdd:pfam17802 2 TGKPLAGAEFTLYDADgtvdGKVVGTLTTDEDGKATFDGLPPGTYTLkETKAPDGYVLDD 61
|
|
| bMG3 |
pfam11974 |
Bacterial alpha-2-macroglobulin MG3 domain; This is the MG3 domain from bacterial ... |
1035-1066 |
6.15e-04 |
|
Bacterial alpha-2-macroglobulin MG3 domain; This is the MG3 domain from bacterial alpha2-macroglobulins.
Pssm-ID: 432232 [Multi-domain] Cd Length: 102 Bit Score: 40.66 E-value: 6.15e-04
10 20 30
....*....|....*....|....*....|..
gi 446857215 1035 KGIKDVKVILLNEKGEVIGTTKTDENGKYRFD 1066
Cdd:pfam11974 26 KPVAGVEVRLLDCNGQVLATGTTDAQGHARFE 57
|
|
| Peptidase_M14NE-CP-C_like |
cd11308 |
Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, ... |
918-984 |
8.02e-04 |
|
Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; This domain is found C-terminal to the M14 carboxypeptidase (CP) N/E subfamily containing zinc-binding enzymes that hydrolyze single C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key determinant of specificity. The N/E subfamily includes enzymatically active members (carboxypeptidase N, E, M, D, and Z), as well as non-active members (carboxypeptidase-like protein 1, -2, aortic CP-like protein, and adipocyte enhancer binding protein-1) which lack the critical active site and substrate-binding residues considered necessary for activity. The active N/E enzymes fulfill a variety of cellular functions, including prohormone processing, regulation of peptide hormone activity, alteration of protein-protein or protein-cell interactions and transcriptional regulation. For M14 CPs, it has been suggested that this domain may assist in folding of the CP domain, regulate enzyme activity, or be involved in interactions with other proteins or with membranes; for carboxypeptidase M, it may interact with the bradykinin 1 receptor at the cell surface. This domain may also be found in other peptidase families.
Pssm-ID: 200604 [Multi-domain] Cd Length: 76 Bit Score: 39.43 E-value: 8.02e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446857215 918 VQDKDEKGISGVTVTLKDENdkvlKTVTTDENGKYqFTDLNNGTYKVEFETPsGYTP--TSVTSGNDTE 984
Cdd:cd11308 6 VTDATGNPIANATISVEGIN----HDVTTAKDGDY-WRLLLPGTYNVTASAP-GYQPvtKTVTVPNNFS 68
|
|
| MetallophosN |
pfam16371 |
N terminal of Calcineurin-like phosphoesterase; This is the N-terminal of Calcineurin-like ... |
812-872 |
1.19e-03 |
|
N terminal of Calcineurin-like phosphoesterase; This is the N-terminal of Calcineurin-like phosphoesterases. It is around 150 residues in length from various Bacteroides species. The function of this family is unknown.
Pssm-ID: 435307 Cd Length: 73 Bit Score: 38.69 E-value: 1.19e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446857215 812 TEKGISGVTVTlkneNGEvlQTTKTDKDGKYQFTGLENGTYkVEFETPSGYTPTQVGSGTD 872
Cdd:pfam16371 1 NGKGLAGVVVS----DGY--NFTKTDANGRYTLPDDKKAKF-VYISTPAGYEVPTDDGITP 54
|
|
| LPXTG_anchor |
TIGR01167 |
LPXTG-motif cell wall anchor domain; This model describes the LPXTG motif-containing region ... |
1348-1382 |
1.75e-03 |
|
LPXTG-motif cell wall anchor domain; This model describes the LPXTG motif-containing region found at the C-terminus of many surface proteins of Streptococcus and Streptomyces species. Cleavage between the Thr and Gly by sortase or a related enzyme leads to covalent anchoring at the new C-terminal Thr to the cell wall. Hits that do not lie at the C-terminus or are not found in Gram-positive bacteria are probably false-positive. A common feature of this proteins containing this domain appears to be a high proportion of charged and zwitterionic residues immediatedly upstream of the LPXTG motif. This model differs from other descriptions of the LPXTG region by including a portion of that upstream charged region. [Cell envelope, Other]
Pssm-ID: 273478 [Multi-domain] Cd Length: 34 Bit Score: 37.07 E-value: 1.75e-03
10 20 30
....*....|....*....|....*....|....*
gi 446857215 1348 LPETGNenSGSNNATLFGGLFAALGSLLLFGRRKK 1382
Cdd:TIGR01167 2 LPKTGE--SGNSLLLLLGLLLLGLGGLLLRKRKKK 34
|
|
| bMG3 |
pfam11974 |
Bacterial alpha-2-macroglobulin MG3 domain; This is the MG3 domain from bacterial ... |
814-851 |
4.39e-03 |
|
Bacterial alpha-2-macroglobulin MG3 domain; This is the MG3 domain from bacterial alpha2-macroglobulins.
Pssm-ID: 432232 [Multi-domain] Cd Length: 102 Bit Score: 37.96 E-value: 4.39e-03
10 20 30
....*....|....*....|....*....|....*...
gi 446857215 814 KGISGVTVTLKNENGEVLQTTKTDKDGKYQFTGLENGT 851
Cdd:pfam11974 26 KPVAGVEVRLLDCNGQVLATGTTDAQGHARFEGPLTRD 63
|
|
| bMG3 |
pfam11974 |
Bacterial alpha-2-macroglobulin MG3 domain; This is the MG3 domain from bacterial ... |
700-738 |
5.33e-03 |
|
Bacterial alpha-2-macroglobulin MG3 domain; This is the MG3 domain from bacterial alpha2-macroglobulins.
Pssm-ID: 432232 [Multi-domain] Cd Length: 102 Bit Score: 37.96 E-value: 5.33e-03
10 20 30
....*....|....*....|....*....|....*....
gi 446857215 700 QDEKGISGVTVTLKDENGNVLKTVTTDADGKYKFTDLDN 738
Cdd:pfam11974 23 DSGKPVAGVEVRLLDCNGQVLATGTTDAQGHARFEGPLT 61
|
|
| Transthyretin |
pfam00576 |
HIUase/Transthyretin family; This family includes transthyretin that is a thyroid ... |
927-968 |
5.39e-03 |
|
HIUase/Transthyretin family; This family includes transthyretin that is a thyroid hormone-binding protein that transports thyroxine from the bloodstream to the brain. However, most of the sequences listed in this family do not bind thyroid hormones. They are actually enzymes of the purine catabolism that catalyze the conversion of 5-hydroxyisourate (HIU) to OHCU. HIU hydrolysis is the original function of the family and is conserved from bacteria to mammals; transthyretins arose by gene duplications in the vertebrate lineage. HIUases are distinguished in the alignment from the conserved C-terminal YRGS sequence.
Pssm-ID: 459857 Cd Length: 108 Bit Score: 37.81 E-value: 5.39e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 446857215 927 SGVTVTL---KDENDKVLKTVTTDENGKY-----QFTDLNNGTYKVEFET 968
Cdd:pfam00576 15 AGVRVTLyrlDGDGWTLLAEGTTNADGRCddlllEGEALEPGTYRLVFDT 64
|
|
| |
