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Conserved domains on  [gi|446756744|ref|WP_000834000|]
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MULTISPECIES: antibiotic biosynthesis monooxygenase [Bacillus]

Protein Classification

antibiotic biosynthesis monooxygenase family protein( domain architecture ID 10006366)

antibiotic biosynthesis monooxygenase family protein may be involved in the biosynthesis of several antibiotics; similar to Streptomyces tetracenomycin-F1 monooxygenase and deoxynogalonate monooxygenase

CATH:  3.30.70.100
EC:  1.-.-.-
Gene Ontology:  GO:0004497|GO:0017000|GO:0016491
PubMed:  31399587
SCOP:  4001439

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HmoA COG2329
Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and ...
 11-96 3.57e-20

Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and metabolism];


:

Pssm-ID: 441901  Cd Length: 98  Bit Score: 78.11  E-value: 3.57e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446756744  11 YYAVIFTSNLSNDTTD-YSTVAETMEELAKQQPGFLGVESAR--DNSGLGITISYWESLEAIENWKKNALHKEAKKRGRE 87
Cdd:COG2329    1 MIVVINRFRVKPGQEEeFEEAFAERRELLAEQPGFLGFELLRslEDPGEYLVVSYWESEEAFRAWFRSSEHRAAHAKGRE 80

                         90
                 ....*....|....
gi 446756744  88 QW-----YENFHLR 96
Cdd:COG2329   81 ILagpprVEHYEVV 94
 
Name Accession Description Interval E-value
HmoA COG2329
Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and ...
 11-96 3.57e-20

Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and metabolism];


Pssm-ID: 441901  Cd Length: 98  Bit Score: 78.11  E-value: 3.57e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446756744  11 YYAVIFTSNLSNDTTD-YSTVAETMEELAKQQPGFLGVESAR--DNSGLGITISYWESLEAIENWKKNALHKEAKKRGRE 87
Cdd:COG2329    1 MIVVINRFRVKPGQEEeFEEAFAERRELLAEQPGFLGFELLRslEDPGEYLVVSYWESEEAFRAWFRSSEHRAAHAKGRE 80

                         90
                 ....*....|....
gi 446756744  88 QW-----YENFHLR 96
Cdd:COG2329   81 ILagpprVEHYEVV 94
ABM pfam03992
Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the ...
 25-81 7.39e-07

Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.


Pssm-ID: 427635  Cd Length: 74  Bit Score: 43.03  E-value: 7.39e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 446756744   25 TDYSTVAETMEELAKQQPGFLGVESARD--NSGLGITISYWESLEAIENWKKNALHKEA 81
Cdd:pfam03992  15 EEFEEALAELVEATRNEPGCLSYELLRSleDPDEYVVLEVWEDEAAFEAHLQSPHFKAA 73
 
Name Accession Description Interval E-value
HmoA COG2329
Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and ...
 11-96 3.57e-20

Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and metabolism];


Pssm-ID: 441901  Cd Length: 98  Bit Score: 78.11  E-value: 3.57e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446756744  11 YYAVIFTSNLSNDTTD-YSTVAETMEELAKQQPGFLGVESAR--DNSGLGITISYWESLEAIENWKKNALHKEAKKRGRE 87
Cdd:COG2329    1 MIVVINRFRVKPGQEEeFEEAFAERRELLAEQPGFLGFELLRslEDPGEYLVVSYWESEEAFRAWFRSSEHRAAHAKGRE 80

                         90
                 ....*....|....
gi 446756744  88 QW-----YENFHLR 96
Cdd:COG2329   81 ILagpprVEHYEVV 94
ABM pfam03992
Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the ...
 25-81 7.39e-07

Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.


Pssm-ID: 427635  Cd Length: 74  Bit Score: 43.03  E-value: 7.39e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 446756744   25 TDYSTVAETMEELAKQQPGFLGVESARD--NSGLGITISYWESLEAIENWKKNALHKEA 81
Cdd:pfam03992  15 EEFEEALAELVEATRNEPGCLSYELLRSleDPDEYVVLEVWEDEAAFEAHLQSPHFKAA 73
DUF4188 pfam13826
Domain of unknown function (DUF4188);
34-81 9.83e-06

Domain of unknown function (DUF4188);


Pssm-ID: 433506  Cd Length: 118  Bit Score: 41.07  E-value: 9.83e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 446756744   34 MEELAKQQP-GFLGVESARDNSGLGITISYWESLEAIENWKKNALHKEA 81
Cdd:pfam13826  30 LRELRADPElGLLGYESYIGAPREVMLVQYWRDFESLHAFAHSEPHREA 78
DUF3291 pfam11695
Domain of unknown function (DUF3291); This bacterial family of proteins has no known function.
 36-91 2.40e-04

Domain of unknown function (DUF3291); This bacterial family of proteins has no known function.


Pssm-ID: 432007  Cd Length: 136  Bit Score: 37.98  E-value: 2.40e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446756744   36 ELAKQQPGFLG--VESARDNSGLG--------ITISYWESLEAIENWKKNALHKEAKKRGREqWYE 91
Cdd:pfam11695  27 ALADASPGFVWrlQDEGGDATAIRpfgddlliVNLSVWESVEALRAFVYRSEHREVLRRRRE-WFE 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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