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Conserved domains on  [gi|446627561|ref|WP_000704907|]
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MULTISPECIES: UDP-glucose 6-dehydrogenase [Enterobacteriaceae]

Protein Classification

UDP-glucose 6-dehydrogenase family protein( domain architecture ID 1001292)

UDP-glucose 6-dehydrogenase is involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate; may be partial

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK15057 super family cl33071
UDP-glucose 6-dehydrogenase; Provisional
1-388 0e+00

UDP-glucose 6-dehydrogenase; Provisional


The actual alignment was detected with superfamily member PRK15057:

Pssm-ID: 185017 [Multi-domain]  Cd Length: 388  Bit Score: 747.62  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561   1 MKITISGTGYVGLSNGVLIAQNHEVVALDIVQAKVDMLNQKISPIVDKEIQEYLAEKPLNFRATTDKHDAYRNADYVIIA 80
Cdd:PRK15057   1 MKITISGTGYVGLSNGLLIAQNHEVVALDILPSRVAMLNDRISPIVDKEIQQFLQSDKIHFNATLDKNEAYRDADYVIIA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561  81 TPTDYDPKTNYFNTSTVEAVIRDVTEINPNAVMIIKSTIPVGFTRDIKERLGIDNVIFSPEFLREGRALYDNLHPSRIVI 160
Cdd:PRK15057  81 TPTDYDPKTNYFNTSSVESVIKDVVEINPYAVMVIKSTVPVGFTAAMHKKYRTENIIFSPEFLREGKALYDNLHPSRIVI 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561 161 GERSARAERFADLLKEGAIKQDIPTLFTDSTEAEAIKLFANTYLALRVAYFNELDSYAESQGLNSKQIIEGVCLDPRIGN 240
Cdd:PRK15057 161 GERSERAERFAALLQEGAIKQNIPTLFTDSTEAEAIKLFANTYLAMRVAYFNELDSYAESLGLNTRQIIEGVCLDPRIGN 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561 241 HYNNPSFGYGGYCLPKDTKQLLANYESVPNNIIAAIVDANRTRKDFIADSILARKPKVVGVYRLIMKSGSDNFRASSIQG 320
Cdd:PRK15057 241 HYNNPSFGYGGYCLPKDTKQLLANYQSVPNNLISAIVDANRTRKDFIADAILSRKPQVVGIYRLIMKSGSDNFRASSIQG 320
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446627561 321 IMKRIKAKGIPVIIYEPVMQEDEFFNSRVVRDLDAFKQEADVIISNRMAEELADVADKVYTRDLFGND 388
Cdd:PRK15057 321 IMKRIKAKGVEVIIYEPVMKEDSFFNSRLERDLATFKQQADVIISNRMAEELKDVADKVYTRDLFGSD 388
 
Name Accession Description Interval E-value
PRK15057 PRK15057
UDP-glucose 6-dehydrogenase; Provisional
1-388 0e+00

UDP-glucose 6-dehydrogenase; Provisional


Pssm-ID: 185017 [Multi-domain]  Cd Length: 388  Bit Score: 747.62  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561   1 MKITISGTGYVGLSNGVLIAQNHEVVALDIVQAKVDMLNQKISPIVDKEIQEYLAEKPLNFRATTDKHDAYRNADYVIIA 80
Cdd:PRK15057   1 MKITISGTGYVGLSNGLLIAQNHEVVALDILPSRVAMLNDRISPIVDKEIQQFLQSDKIHFNATLDKNEAYRDADYVIIA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561  81 TPTDYDPKTNYFNTSTVEAVIRDVTEINPNAVMIIKSTIPVGFTRDIKERLGIDNVIFSPEFLREGRALYDNLHPSRIVI 160
Cdd:PRK15057  81 TPTDYDPKTNYFNTSSVESVIKDVVEINPYAVMVIKSTVPVGFTAAMHKKYRTENIIFSPEFLREGKALYDNLHPSRIVI 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561 161 GERSARAERFADLLKEGAIKQDIPTLFTDSTEAEAIKLFANTYLALRVAYFNELDSYAESQGLNSKQIIEGVCLDPRIGN 240
Cdd:PRK15057 161 GERSERAERFAALLQEGAIKQNIPTLFTDSTEAEAIKLFANTYLAMRVAYFNELDSYAESLGLNTRQIIEGVCLDPRIGN 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561 241 HYNNPSFGYGGYCLPKDTKQLLANYESVPNNIIAAIVDANRTRKDFIADSILARKPKVVGVYRLIMKSGSDNFRASSIQG 320
Cdd:PRK15057 241 HYNNPSFGYGGYCLPKDTKQLLANYQSVPNNLISAIVDANRTRKDFIADAILSRKPQVVGIYRLIMKSGSDNFRASSIQG 320
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446627561 321 IMKRIKAKGIPVIIYEPVMQEDEFFNSRVVRDLDAFKQEADVIISNRMAEELADVADKVYTRDLFGND 388
Cdd:PRK15057 321 IMKRIKAKGVEVIIYEPVMKEDSFFNSRLERDLATFKQQADVIISNRMAEELKDVADKVYTRDLFGSD 388
NDP-sugDHase TIGR03026
nucleotide sugar dehydrogenase; Enzymes in this family catalyze the NAD-dependent ...
1-378 3.96e-124

nucleotide sugar dehydrogenase; Enzymes in this family catalyze the NAD-dependent alcohol-to-acid oxidation of nucleotide-linked sugars. Examples include UDP-glucose 6-dehydrogenase (1.1.1.22), GDP-mannose 6-dehydrogenase (1.1.1.132), UDP-N-acetylglucosamine 6-dehydrogenase (1.1.1.136), UDP-N-acetyl-D-galactosaminuronic acid dehydrogenase, and UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase. These enzymes are most often involved in the biosynthesis of polysaccharides and are often found in operons devoted to that purpose. All of these enzymes contain three Pfam domains, pfam03721, pfam00984, and pfam03720 for the N-terminal, central, and C-terminal regions respectively.


Pssm-ID: 274399 [Multi-domain]  Cd Length: 409  Bit Score: 364.24  E-value: 3.96e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561    1 MKITISGTGYVGLSNGVLIA-QNHEVVALDIVQAKVDMLNQKISPIVDKEIQEYLAE--KPLNFRATTDKHDAYRNADYV 77
Cdd:TIGR03026   1 MKIAVIGLGYVGLPLAALLAdLGHDVTGVDIDQEKVDKLNKGKSPIYEPGLDELLAKalKAGRLRATTDYEEAIRDADVI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561   78 IIATPTDYDPkTNYFNTSTVEAVIRDVTE-INPNAVMIIKSTIPVGFTRD----IKERLGID-----NVIFSPEFLREGR 147
Cdd:TIGR03026  81 IICVPTPLKE-DGSPDLSYVESAAETIAKhLRKGATVVLESTVPPGTTEEvvkpILERSGLKlgedfYLAYNPEFLREGN 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561  148 ALYDNLHPSRIVIGERSARAERFADLLKEGAikqDIPTLFTDSTEAEAIKLFANTYLALRVAYFNELDSYAESQGLNSKQ 227
Cdd:TIGR03026 160 AVHDLLHPDRIVGGETEEAGEAVAELYSPII---DGPVLVTSIETAEMIKLAENTFRAVKIAFANELARICEALGIDVYE 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561  228 IIEGVCLDPRIGNHYNNPSFGYGGYCLPKDTKQLLANYES--VPNNIIAAIVDANRTRKDFIADSILAR----KPKVVGV 301
Cdd:TIGR03026 237 VIEAAGTDPRIGFNFLNPGPGVGGHCIPKDPLALIAKAKElgYNPELIEAAREINDSQPDYVVEKIKDLlgplKGKTVLI 316
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446627561  302 YRLIMKSGSDNFRASSIQGIMKRIKAKGIPVIIYEPVMQEDEFFNSRVVRDLDAFKQEADVIISNRMAEELADVADK 378
Cdd:TIGR03026 317 LGLAFKPNTDDVRESPALDIIELLKEKGAKVKAYDPLVPEEEVKGLPSIDDLEEALKGADALVILTDHSEFKDLDLE 393
Ugd COG1004
UDP-glucose 6-dehydrogenase [Cell wall/membrane/envelope biogenesis];
1-341 1.25e-71

UDP-glucose 6-dehydrogenase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440628 [Multi-domain]  Cd Length: 436  Bit Score: 230.29  E-value: 1.25e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561   1 MKITISGTGYVGLSNGVLIAQ-NHEVVALDIVQAKVDMLNQKISPI----VDKEIQEYLAEKPLNFraTTDKHDAYRNAD 75
Cdd:COG1004    1 MKIAVIGTGYVGLVTAACLAElGHEVTCVDIDEEKIEALNAGEIPIyepgLEELVARNVAAGRLRF--TTDLAEAVAEAD 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561  76 YVIIA--TPTDYDpktNYFNTSTVEAVIRDVTE-INPNAVMIIKSTIPVGFTRDIKERL-------GID-NVIFSPEFLR 144
Cdd:COG1004   79 VVFIAvgTPSDED---GSADLSYVLAAARSIGEaLKGYKVVVTKSTVPVGTADRVRAIIaeelrgaGVDfDVVSNPEFLR 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561 145 EGRALYDNLHPSRIVIGERSARAERFADLLKEGAIKQDIPTLFTDSTEAEAIKLFANTYLALRVAYFNELDSYAESQGLN 224
Cdd:COG1004  156 EGSAVEDFLRPDRIVIGVDSERAAEVLRELYAPFVRNGTPIIVTDLRSAELIKYAANAFLATKISFINEIANLCEKVGAD 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561 225 SKQIIEGVCLDPRIGNHYNNPSFGYGGYCLPKDTKQLLANYES--VPNNIIAAIVDANRTRKDFIADSILAR-----KPK 297
Cdd:COG1004  236 VEEVARGIGLDSRIGPKFLYAGIGYGGSCFPKDVRALIATARElgYDLRLLEAVEEVNERQKRRLVEKIREHlggdlKGK 315
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 446627561 298 VVGVYRLIMKSGSDNFR-ASSIQgIMKRIKAKGIPVIIYEPV-MQE 341
Cdd:COG1004  316 TIAVLGLAFKPNTDDMReSPALD-IIEALLEAGARVRAYDPVaMEN 360
UDPG_MGDP_dh_N pfam03721
UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; The UDP-glucose/GDP-mannose ...
1-168 7.90e-37

UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; The UDP-glucose/GDP-mannose dehydrogenaseses are a small group of enzymes which possesses the ability to catalyze the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde intermediate.


Pssm-ID: 397677 [Multi-domain]  Cd Length: 186  Bit Score: 131.99  E-value: 7.90e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561    1 MKITISGTGYVGLSNGVLIAQ-NHEVVALDIVQAKVDMLNQKISPIVDKEIQEYLAE-KPLNFRATTDKHDAYRNADYVI 78
Cdd:pfam03721   1 MKISVIGLGYVGLPTAACLAEiGHDVIGVDIDEEKVDKLNSGQIPIYEPGLDELVKAnVSGRLSFTTDYSTAIEEADVIF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561   79 IATPTDYDPKTNYFNTSTVEAVIRDVTE-INPNAVMIIKSTIPVGFTRDIKERL--------GID-NVIFSPEFLREGRA 148
Cdd:pfam03721  81 IAVGTPSKKGGGAADLKYVESAARSIAPhLKKGKVVVVKSTVPVGTTENLVKPIieeggkkvGVDfDVASNPEFLREGSA 160
                         170       180
                  ....*....|....*....|
gi 446627561  149 LYDNLHPSRIVIGERSARAE 168
Cdd:pfam03721 161 VYDLFNPDRVVIGVTEKCAE 180
UDPG_MGDP_dh_C smart00984
UDP binding domain; The UDP-glucose/GDP-mannose dehydrogenases are a small group of enzymes ...
300-385 2.75e-17

UDP binding domain; The UDP-glucose/GDP-mannose dehydrogenases are a small group of enzymes which possesses the ability to catalyse the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde intermediate.


Pssm-ID: 214954 [Multi-domain]  Cd Length: 99  Bit Score: 76.39  E-value: 2.75e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561   300 GVYRLIMKSGSDNFRASSIQGIMKRIKAKGIPVIIYEP-VMQE-DEFFNSRVVRDLDAFKQEADVIISNRMAE------- 370
Cdd:smart00984   1 AVLGLAFKPNTDDLRESPALDIIEELLEAGAEVVVYDPyAMEEaREYGLTYVSDLEEALKGADAVVIATEHDEfrsldpe 80
                           90
                   ....*....|....*...
gi 446627561   371 ELADVADK---VYTRDLF 385
Cdd:smart00984  81 ELKDLMKKpvvVDGRNIL 98
LDH_MDH_like cd00650
NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Members ...
24-122 3.73e-03

NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Members of this family include ubiquitous enzymes like L-lactate dehydrogenases (LDH), L-2-hydroxyisocaproate dehydrogenases, and some malate dehydrogenases (MDH). LDH catalyzes the last step of glycolysis in which pyruvate is converted to L-lactate. MDH is one of the key enzymes in the citric acid cycle, facilitating both the conversion of malate to oxaloacetate and replenishing levels of oxalacetate by reductive carboxylation of pyruvate. The LDH/MDH-like proteins are part of the NAD(P)-binding Rossmann fold superfamily, which includes a wide variety of protein families including the NAD(P)-binding domains of alcohol dehydrogenases, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate dehydrogenases, formate/glycerate dehydrogenases, siroheme synthases, 6-phosphogluconate dehydrogenases, aminoacid dehydrogenases, repressor rex, and NAD-binding potassium channel domains, among others.


Pssm-ID: 133419 [Multi-domain]  Cd Length: 263  Bit Score: 38.84  E-value: 3.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561  24 EVVALDIVQAKVDmlnqkispIVDKEIQEYLAEKPL-NFRATTDKHDAYRNADYVIIAT-----PTDYDPKTNYFNTSTV 97
Cdd:cd00650   28 ELVLYDIDEEKLK--------GVAMDLQDAVEPLADiKVSITDDPYEAFKDADVVIITAgvgrkPGMGRLDLLKRNVPIV 99
                         90       100
                 ....*....|....*....|....*
gi 446627561  98 EAVIRDVTEINPNAVMIIKSTiPVG 122
Cdd:cd00650  100 KEIGDNIEKYSPDAWIIVVSN-PVD 123
 
Name Accession Description Interval E-value
PRK15057 PRK15057
UDP-glucose 6-dehydrogenase; Provisional
1-388 0e+00

UDP-glucose 6-dehydrogenase; Provisional


Pssm-ID: 185017 [Multi-domain]  Cd Length: 388  Bit Score: 747.62  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561   1 MKITISGTGYVGLSNGVLIAQNHEVVALDIVQAKVDMLNQKISPIVDKEIQEYLAEKPLNFRATTDKHDAYRNADYVIIA 80
Cdd:PRK15057   1 MKITISGTGYVGLSNGLLIAQNHEVVALDILPSRVAMLNDRISPIVDKEIQQFLQSDKIHFNATLDKNEAYRDADYVIIA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561  81 TPTDYDPKTNYFNTSTVEAVIRDVTEINPNAVMIIKSTIPVGFTRDIKERLGIDNVIFSPEFLREGRALYDNLHPSRIVI 160
Cdd:PRK15057  81 TPTDYDPKTNYFNTSSVESVIKDVVEINPYAVMVIKSTVPVGFTAAMHKKYRTENIIFSPEFLREGKALYDNLHPSRIVI 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561 161 GERSARAERFADLLKEGAIKQDIPTLFTDSTEAEAIKLFANTYLALRVAYFNELDSYAESQGLNSKQIIEGVCLDPRIGN 240
Cdd:PRK15057 161 GERSERAERFAALLQEGAIKQNIPTLFTDSTEAEAIKLFANTYLAMRVAYFNELDSYAESLGLNTRQIIEGVCLDPRIGN 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561 241 HYNNPSFGYGGYCLPKDTKQLLANYESVPNNIIAAIVDANRTRKDFIADSILARKPKVVGVYRLIMKSGSDNFRASSIQG 320
Cdd:PRK15057 241 HYNNPSFGYGGYCLPKDTKQLLANYQSVPNNLISAIVDANRTRKDFIADAILSRKPQVVGIYRLIMKSGSDNFRASSIQG 320
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446627561 321 IMKRIKAKGIPVIIYEPVMQEDEFFNSRVVRDLDAFKQEADVIISNRMAEELADVADKVYTRDLFGND 388
Cdd:PRK15057 321 IMKRIKAKGVEVIIYEPVMKEDSFFNSRLERDLATFKQQADVIISNRMAEELKDVADKVYTRDLFGSD 388
NDP-sugDHase TIGR03026
nucleotide sugar dehydrogenase; Enzymes in this family catalyze the NAD-dependent ...
1-378 3.96e-124

nucleotide sugar dehydrogenase; Enzymes in this family catalyze the NAD-dependent alcohol-to-acid oxidation of nucleotide-linked sugars. Examples include UDP-glucose 6-dehydrogenase (1.1.1.22), GDP-mannose 6-dehydrogenase (1.1.1.132), UDP-N-acetylglucosamine 6-dehydrogenase (1.1.1.136), UDP-N-acetyl-D-galactosaminuronic acid dehydrogenase, and UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase. These enzymes are most often involved in the biosynthesis of polysaccharides and are often found in operons devoted to that purpose. All of these enzymes contain three Pfam domains, pfam03721, pfam00984, and pfam03720 for the N-terminal, central, and C-terminal regions respectively.


Pssm-ID: 274399 [Multi-domain]  Cd Length: 409  Bit Score: 364.24  E-value: 3.96e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561    1 MKITISGTGYVGLSNGVLIA-QNHEVVALDIVQAKVDMLNQKISPIVDKEIQEYLAE--KPLNFRATTDKHDAYRNADYV 77
Cdd:TIGR03026   1 MKIAVIGLGYVGLPLAALLAdLGHDVTGVDIDQEKVDKLNKGKSPIYEPGLDELLAKalKAGRLRATTDYEEAIRDADVI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561   78 IIATPTDYDPkTNYFNTSTVEAVIRDVTE-INPNAVMIIKSTIPVGFTRD----IKERLGID-----NVIFSPEFLREGR 147
Cdd:TIGR03026  81 IICVPTPLKE-DGSPDLSYVESAAETIAKhLRKGATVVLESTVPPGTTEEvvkpILERSGLKlgedfYLAYNPEFLREGN 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561  148 ALYDNLHPSRIVIGERSARAERFADLLKEGAikqDIPTLFTDSTEAEAIKLFANTYLALRVAYFNELDSYAESQGLNSKQ 227
Cdd:TIGR03026 160 AVHDLLHPDRIVGGETEEAGEAVAELYSPII---DGPVLVTSIETAEMIKLAENTFRAVKIAFANELARICEALGIDVYE 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561  228 IIEGVCLDPRIGNHYNNPSFGYGGYCLPKDTKQLLANYES--VPNNIIAAIVDANRTRKDFIADSILAR----KPKVVGV 301
Cdd:TIGR03026 237 VIEAAGTDPRIGFNFLNPGPGVGGHCIPKDPLALIAKAKElgYNPELIEAAREINDSQPDYVVEKIKDLlgplKGKTVLI 316
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446627561  302 YRLIMKSGSDNFRASSIQGIMKRIKAKGIPVIIYEPVMQEDEFFNSRVVRDLDAFKQEADVIISNRMAEELADVADK 378
Cdd:TIGR03026 317 LGLAFKPNTDDVRESPALDIIELLKEKGAKVKAYDPLVPEEEVKGLPSIDDLEEALKGADALVILTDHSEFKDLDLE 393
Ugd COG1004
UDP-glucose 6-dehydrogenase [Cell wall/membrane/envelope biogenesis];
1-341 1.25e-71

UDP-glucose 6-dehydrogenase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440628 [Multi-domain]  Cd Length: 436  Bit Score: 230.29  E-value: 1.25e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561   1 MKITISGTGYVGLSNGVLIAQ-NHEVVALDIVQAKVDMLNQKISPI----VDKEIQEYLAEKPLNFraTTDKHDAYRNAD 75
Cdd:COG1004    1 MKIAVIGTGYVGLVTAACLAElGHEVTCVDIDEEKIEALNAGEIPIyepgLEELVARNVAAGRLRF--TTDLAEAVAEAD 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561  76 YVIIA--TPTDYDpktNYFNTSTVEAVIRDVTE-INPNAVMIIKSTIPVGFTRDIKERL-------GID-NVIFSPEFLR 144
Cdd:COG1004   79 VVFIAvgTPSDED---GSADLSYVLAAARSIGEaLKGYKVVVTKSTVPVGTADRVRAIIaeelrgaGVDfDVVSNPEFLR 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561 145 EGRALYDNLHPSRIVIGERSARAERFADLLKEGAIKQDIPTLFTDSTEAEAIKLFANTYLALRVAYFNELDSYAESQGLN 224
Cdd:COG1004  156 EGSAVEDFLRPDRIVIGVDSERAAEVLRELYAPFVRNGTPIIVTDLRSAELIKYAANAFLATKISFINEIANLCEKVGAD 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561 225 SKQIIEGVCLDPRIGNHYNNPSFGYGGYCLPKDTKQLLANYES--VPNNIIAAIVDANRTRKDFIADSILAR-----KPK 297
Cdd:COG1004  236 VEEVARGIGLDSRIGPKFLYAGIGYGGSCFPKDVRALIATARElgYDLRLLEAVEEVNERQKRRLVEKIREHlggdlKGK 315
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 446627561 298 VVGVYRLIMKSGSDNFR-ASSIQgIMKRIKAKGIPVIIYEPV-MQE 341
Cdd:COG1004  316 TIAVLGLAFKPNTDDMReSPALD-IIEALLEAGARVRAYDPVaMEN 360
WecC COG0677
UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell wall/membrane/envelope biogenesis];
2-364 4.18e-40

UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440441 [Multi-domain]  Cd Length: 413  Bit Score: 146.75  E-value: 4.18e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561   2 KITISGTGYVGLSNGVLIAQN-HEVVALDIVQAKVDMLNQKISPIV---DKEIQEYLAEKplNFRATTDKhDAYRNADYV 77
Cdd:COG0677    1 KIAVIGLGYVGLPLAVAFAKAgFRVIGFDINPERVEELNAGEDPILepgDELLAEAVAAG--RLRATTDP-EALAEADVV 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561  78 IIATPTDYDpKTNYFNTSTVEAVIRDVTE-INPNAVMIIKSTIPVGFTRDI-----KERLGID-----NVIFSPEflRE- 145
Cdd:COG0677   78 IIAVPTPLD-EDKEPDLSYLESASETIAPhLKPGDLVVLESTVYPGTTEEVcvpilEKRSGLKagedfFLAYSPE--RIn 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561 146 -GRALYDNLHPSRIV--IGERSA-RAERF-ADLLKEGAIKQdiptlfTDSTEAEAIKLFANTYLALRVAYFNELDSYAES 220
Cdd:COG0677  155 pGNKLHELRNIPKVVggITPESAeRAAALyGSVVTAGVVPV------SSIKVAEAAKLIENTYRDVNIALANELALICDR 228
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561 221 QGLNSKQIIEGVCLDPRIGNHYnnPSFGYGGYCLPKDTKQLLANYESVPNN--IIAAIVDANRTRKDFIAD---SILARK 295
Cdd:COG0677  229 LGIDVWEVIEAANTKPGFLIFY--PGPGVGGHCIPVDPYYLTWKARELGYHprLILAAREINDSMPEYVVErvvKALNEA 306
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446627561 296 PK-----VVGVYRLIMKSGSDNFRASSIQGIMKRIKAKGIPVIIYEPVMQEDEFFN-SRVVRDLDAFKQEADVII 364
Cdd:COG0677  307 GKslkgaRVLVLGLAYKENVDDLRESPALDIIEELREYGAEVDVHDPYVDEEEVEGeYGELVDLEEALEGADAVV 381
UDPG_MGDP_dh_N pfam03721
UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; The UDP-glucose/GDP-mannose ...
1-168 7.90e-37

UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; The UDP-glucose/GDP-mannose dehydrogenaseses are a small group of enzymes which possesses the ability to catalyze the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde intermediate.


Pssm-ID: 397677 [Multi-domain]  Cd Length: 186  Bit Score: 131.99  E-value: 7.90e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561    1 MKITISGTGYVGLSNGVLIAQ-NHEVVALDIVQAKVDMLNQKISPIVDKEIQEYLAE-KPLNFRATTDKHDAYRNADYVI 78
Cdd:pfam03721   1 MKISVIGLGYVGLPTAACLAEiGHDVIGVDIDEEKVDKLNSGQIPIYEPGLDELVKAnVSGRLSFTTDYSTAIEEADVIF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561   79 IATPTDYDPKTNYFNTSTVEAVIRDVTE-INPNAVMIIKSTIPVGFTRDIKERL--------GID-NVIFSPEFLREGRA 148
Cdd:pfam03721  81 IAVGTPSKKGGGAADLKYVESAARSIAPhLKKGKVVVVKSTVPVGTTENLVKPIieeggkkvGVDfDVASNPEFLREGSA 160
                         170       180
                  ....*....|....*....|
gi 446627561  149 LYDNLHPSRIVIGERSARAE 168
Cdd:pfam03721 161 VYDLFNPDRVVIGVTEKCAE 180
UDPG_MGDP_dh pfam00984
UDP-glucose/GDP-mannose dehydrogenase family, central domain; The UDP-glucose/GDP-mannose ...
192-281 2.39e-32

UDP-glucose/GDP-mannose dehydrogenase family, central domain; The UDP-glucose/GDP-mannose dehydrogenaseses are a small group of enzymes which possesses the ability to catalyze the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde intermediate.


Pssm-ID: 460015 [Multi-domain]  Cd Length: 92  Bit Score: 117.09  E-value: 2.39e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561  192 EAEAIKLFANTYLALRVAYFNELDSYAESQGLNSKQIIEGVCLDPRIGNHYNNPSFGYGGYCLPKDTKQLLANYES--VP 269
Cdd:pfam00984   1 SAELIKLAENAFLAVKISFINELANLCEALGADVWEVIEAAGTDPRIGPKFLYPGPGVGGSCLPKDPRALIYLARElgVP 80
                          90
                  ....*....|..
gi 446627561  270 NNIIAAIVDANR 281
Cdd:pfam00984  81 ARLLEAAREVNE 92
PLN02353 PLN02353
probable UDP-glucose 6-dehydrogenase
1-361 3.17e-22

probable UDP-glucose 6-dehydrogenase


Pssm-ID: 177986 [Multi-domain]  Cd Length: 473  Bit Score: 97.82  E-value: 3.17e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561   1 MKITISGTGYVGLSNGVLIAQNH---EVVALDIVQAKVDMLNQKISPIVDKEIQEYLAE---KPLNFRATTDKHDAYRNA 74
Cdd:PLN02353   2 VKICCIGAGYVGGPTMAVIALKCpdiEVVVVDISVPRIDAWNSDQLPIYEPGLDEVVKQcrgKNLFFSTDVEKHVAEADI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561  75 DYVIIATPTdydpKT---------NYFNTSTVEAVIRDVTEinPNAVMIIKSTIPVGFTRDIKERL-----GIDNVIFS- 139
Cdd:PLN02353  82 VFVSVNTPT----KTrglgagkaaDLTYWESAARMIADVSK--SDKIVVEKSTVPVKTAEAIEKILthnskGINFQILSn 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561 140 PEFLREGRALYDNLHPSRIVIGER---------SARAERFADLLKEGAIkqdiptLFTDSTEAEAIKLFANTYLALRVAY 210
Cdd:PLN02353 156 PEFLAEGTAIEDLFKPDRVLIGGRetpegqkavQALKDVYAHWVPEERI------ITTNLWSAELSKLAANAFLAQRISS 229
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561 211 FNELDSYAESQGLNSKQIIEGVCLDPRIGNHYNNPSFGYGGYCLPKDTKQLLANYESVPNNIIAA----IVDANRTRKDF 286
Cdd:PLN02353 230 VNAMSALCEATGADVSQVSHAVGKDSRIGPKFLNASVGFGGSCFQKDILNLVYICECNGLPEVAEywkqVIKMNDYQKSR 309
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561 287 IADSILAR-----KPKVVGVYRLIMKSGSDNFRASSIQGIMKRIKAKGIPVIIYEPVMQEDEFFnsrvvRDLDAFKQEAD 361
Cdd:PLN02353 310 FVNRVVSSmfntvSGKKIAVLGFAFKKDTGDTRETPAIDVCKGLLGDKAKLSIYDPQVTEEQIQ-----RDLSMNKFDWD 384
UDPG_MGDP_dh_C smart00984
UDP binding domain; The UDP-glucose/GDP-mannose dehydrogenases are a small group of enzymes ...
300-385 2.75e-17

UDP binding domain; The UDP-glucose/GDP-mannose dehydrogenases are a small group of enzymes which possesses the ability to catalyse the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde intermediate.


Pssm-ID: 214954 [Multi-domain]  Cd Length: 99  Bit Score: 76.39  E-value: 2.75e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561   300 GVYRLIMKSGSDNFRASSIQGIMKRIKAKGIPVIIYEP-VMQE-DEFFNSRVVRDLDAFKQEADVIISNRMAE------- 370
Cdd:smart00984   1 AVLGLAFKPNTDDLRESPALDIIEELLEAGAEVVVYDPyAMEEaREYGLTYVSDLEEALKGADAVVIATEHDEfrsldpe 80
                           90
                   ....*....|....*...
gi 446627561   371 ELADVADK---VYTRDLF 385
Cdd:smart00984  81 ELKDLMKKpvvVDGRNIL 98
wecC PRK11064
UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional
2-257 6.77e-10

UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional


Pssm-ID: 182940 [Multi-domain]  Cd Length: 415  Bit Score: 60.38  E-value: 6.77e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561   2 KITISGTGYVGLSNGVLIAQ-NHEVVALDIVQAKVDMLNQK----ISPIVDKEIQEYLAEKPLnfRATTdkhdAYRNADY 76
Cdd:PRK11064   5 TISVIGLGYIGLPTAAAFASrQKQVIGVDINQHAVDTINRGeihiVEPDLDMVVKTAVEGGYL--RATT----TPEPADA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561  77 VIIATPT----DYDPKTNYfntstVEAVIRDVTEI-NPNAVMIIKSTIPVGFTRDIKERL-------------GID---N 135
Cdd:PRK11064  79 FLIAVPTpfkgDHEPDLTY-----VEAAAKSIAPVlKKGDLVILESTSPVGATEQMAEWLaearpdltfpqqaGEQadiN 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561 136 VIFSPEFLREGRALYDNLHPSRiVIG----ERSARAERFADLLKEGAikqdipTLFTDSTEAEAIKLFANTYLALRVAYF 211
Cdd:PRK11064 154 IAYCPERVLPGQVMVELIKNDR-VIGgmtpVCSARASELYKIFLEGE------CVVTNSRTAEMCKLTENSFRDVNIAFA 226
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 446627561 212 NELDSYAESQGLNSKQIIEGVCLDPRIgnhyN--NPSFGYGGYCLPKD 257
Cdd:PRK11064 227 NELSLICADQGINVWELIRLANRHPRV----NilQPGPGVGGHCIAVD 270
PRK15182 PRK15182
Vi polysaccharide biosynthesis UDP-N-acetylglucosamine C-6 dehydrogenase TviB;
1-343 9.13e-08

Vi polysaccharide biosynthesis UDP-N-acetylglucosamine C-6 dehydrogenase TviB;


Pssm-ID: 185104 [Multi-domain]  Cd Length: 425  Bit Score: 53.54  E-value: 9.13e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561   1 MKITISGTGYVGLSNGVLIAQNHEVVALDIVQAKVDMLNQKISPIVDKEIQEYLAEKPLNFRATTDKhdaYRNADYVIIA 80
Cdd:PRK15182   7 VKIAIIGLGYVGLPLAVEFGKSRQVVGFDVNKKRILELKNGVDVNLETTEEELREARYLKFTSEIEK---IKECNFYIIT 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561  81 TPTDYDPKTNYFNTSTVEAVIRDVTEINPNAVMIIKSTIPVGFTRD----IKERLgiDNVIFSPEFlregralYDNLHPS 156
Cdd:PRK15182  84 VPTPINTYKQPDLTPLIKASETVGTVLNRGDIVVYESTVYPGCTEEecvpILARM--SGMTFNQDF-------YVGYSPE 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561 157 RIVIGERSAR-----------AERFADLLKEgaIKQDIPTLFTDSTE----AEAIKLFANTYLALRVAYFNELDSYAESQ 221
Cdd:PRK15182 155 RINPGDKKHRltnikkitsgsTAQIAELIDE--VYQQIISAGTYKAEsikvAEAAKVIENTQRDLNIALVNELAIIFNRL 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561 222 GLNSKQIIEGVcldpriGNHYNNPSFG---YGGYCLPKDTKQLLANYESVP--NNIIAAIVDANRTRKDFIADSILARKP 296
Cdd:PRK15182 233 NIDTEAVLRAA------GSKWNFLPFRpglVGGHCIGVDPYYLTHKSQGIGyyPEIILAGRRLNDNMGNYVSEQLIKAMI 306
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446627561 297 K----VVGVYRLIM----KSGSDNFRASSIQGIMKRIKAKGIPVIIYEPVMQEDE 343
Cdd:PRK15182 307 KkginVEGSSVLILgftfKENCPDIRNTRIIDVVKELGKYSCKVDIFDPWVDAEE 361
UDPG_MGDP_dh_C pfam03720
UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; The UDP-glucose/GDP-mannose ...
300-364 7.17e-07

UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; The UDP-glucose/GDP-mannose dehydrogenaseses are a small group of enzymes which possesses the ability to catalyze the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde intermediate.


Pssm-ID: 427462 [Multi-domain]  Cd Length: 103  Bit Score: 47.19  E-value: 7.17e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446627561  300 GVYRLIMKSGSDNFRASSIQGIMKRIKAKGIPVIIYEPV----MQEDEFFNSRVVRDLDAFKQEADVII 364
Cdd:pfam03720   1 AVLGLAFKPNTDDLRESPALDIIELLLEEGAEVKVYDPYvpeeAIEALGDGVTLVDDLEEALKGADAIV 69
PanE COG1893
Ketopantoate reductase [Coenzyme transport and metabolism]; Ketopantoate reductase is part of ...
1-180 4.97e-05

Ketopantoate reductase [Coenzyme transport and metabolism]; Ketopantoate reductase is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 441497 [Multi-domain]  Cd Length: 305  Bit Score: 44.85  E-value: 4.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561   1 MKITISGTG----YVGlsnGVLIAQNHEVVALDiVQAKVDMLNQK----ISPIVDkeiqeylaEKPLNFRATTDKHDAyR 72
Cdd:COG1893    1 MKIAILGAGaiggLLG---ARLARAGHDVTLVA-RGAHAEALRENglrlESPDGD--------RTTVPVPAVTDPEEL-G 67
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561  73 NADYVIIATPTdYDpktnyfntstVEAVIRDVTE-INPNAVMIiksTI--PVGFTRDIKERLGIDNVIFS---PEFLREG 146
Cdd:COG1893   68 PADLVLVAVKA-YD----------LEAAAEALAPlLGPDTVVL---SLqnGLGHEERLAEALGAERVLGGvvtIGATREE 133
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 446627561 147 RALYDNLHPSRIVIGER----SARAERFADLLKEGAIK 180
Cdd:COG1893  134 PGVVRHTGGGRLVLGELdggpSERLEALAELLEAAGIP 171
gpsA PRK00094
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;
1-83 1.01e-03

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;


Pssm-ID: 234629 [Multi-domain]  Cd Length: 325  Bit Score: 40.82  E-value: 1.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561   1 MKITISGTGYVGLSNGVLIAQN-HEVVALDIVQAKVDMLNQkispivDKEIQEYLAEKPL--NFRATTDKHDAYRNADYV 77
Cdd:PRK00094   2 MKIAVLGAGSWGTALAIVLARNgHDVTLWARDPEQAAEINA------DRENPRYLPGIKLpdNLRATTDLAEALADADLI 75

                 ....*.
gi 446627561  78 IIATPT 83
Cdd:PRK00094  76 LVAVPS 81
LDH_MDH_like cd00650
NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Members ...
24-122 3.73e-03

NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Members of this family include ubiquitous enzymes like L-lactate dehydrogenases (LDH), L-2-hydroxyisocaproate dehydrogenases, and some malate dehydrogenases (MDH). LDH catalyzes the last step of glycolysis in which pyruvate is converted to L-lactate. MDH is one of the key enzymes in the citric acid cycle, facilitating both the conversion of malate to oxaloacetate and replenishing levels of oxalacetate by reductive carboxylation of pyruvate. The LDH/MDH-like proteins are part of the NAD(P)-binding Rossmann fold superfamily, which includes a wide variety of protein families including the NAD(P)-binding domains of alcohol dehydrogenases, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate dehydrogenases, formate/glycerate dehydrogenases, siroheme synthases, 6-phosphogluconate dehydrogenases, aminoacid dehydrogenases, repressor rex, and NAD-binding potassium channel domains, among others.


Pssm-ID: 133419 [Multi-domain]  Cd Length: 263  Bit Score: 38.84  E-value: 3.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627561  24 EVVALDIVQAKVDmlnqkispIVDKEIQEYLAEKPL-NFRATTDKHDAYRNADYVIIAT-----PTDYDPKTNYFNTSTV 97
Cdd:cd00650   28 ELVLYDIDEEKLK--------GVAMDLQDAVEPLADiKVSITDDPYEAFKDADVVIITAgvgrkPGMGRLDLLKRNVPIV 99
                         90       100
                 ....*....|....*....|....*
gi 446627561  98 EAVIRDVTEINPNAVMIIKSTiPVG 122
Cdd:cd00650  100 KEIGDNIEKYSPDAWIIVVSN-PVD 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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