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Conserved domains on  [gi|446534752|ref|WP_000612098|]
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MULTISPECIES: homoserine kinase [Bacillus]

Protein Classification

homoserine kinase( domain architecture ID 11479451)

homoserine kinase catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate

EC:  2.7.1.39
Gene Ontology:  GO:0016310|GO:0009088|GO:0004413|GO:0005737|GO:0005524

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK01212 PRK01212
homoserine kinase; Provisional
 1-289 2.14e-125

homoserine kinase; Provisional


:

Pssm-ID: 234920 [Multi-domain]  Cd Length: 301  Bit Score: 359.85  E-value: 2.14e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534752   1 MIPFSVRVPASTANVGPGFDSVGIALSLYLDVVVKEKAD-----KWQVIHSFEESIPAD-DKNLIVSTACKVCPSIS--- 71
Cdd:PRK01212   1 MMMVKVRVPATSANLGPGFDSLGLALSLYDEVLVGDVVSveaefSIEVIGEGADKLPLDpEKNLVYQAALKFLEKLGkpp 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534752  72 PHIIEVTSNIPLTRGLGSSASAIVAGIELANQLGNLNLTADQKVQIATNFEGHPDNVAASILGGTVIGALDGKDVSVVRI 151
Cdd:PRK01212  81 GLRIELEKNIPLGRGLGSSAASIVAGLVAANELAGLPLSKEELLQLATEGEGHPDNVAPALLGGLVLALEENGVISVKIP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534752 152 ESKELGVVSLIPNEELNTDESRSVLPKMFPFHEAVKASAISNVLVAALCQKRWEVVGEMMErDHFHEPYRLELVPLLPSI 231
Cdd:PRK01212 161 VFDDLKWVVAIPNIELSTAEARAVLPKQYSLKDAVFNSSRAALLVAALYTGDYELAGRAMK-DVLHEPYRAKLIPGFAEV 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446534752 232 RKCAKEFGAYGTALSGAGPSIFILAPYEKRQEIAGQLARVFT---DMKVCELEIDHKGIIV 289
Cdd:PRK01212 240 RQAALEAGALGAGISGAGPTVFALCDKEDAEKVADALQKAFLqgiEGFVHVLRLDTAGARV 300
 
Name Accession Description Interval E-value
PRK01212 PRK01212
homoserine kinase; Provisional
 1-289 2.14e-125

homoserine kinase; Provisional


Pssm-ID: 234920 [Multi-domain]  Cd Length: 301  Bit Score: 359.85  E-value: 2.14e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534752   1 MIPFSVRVPASTANVGPGFDSVGIALSLYLDVVVKEKAD-----KWQVIHSFEESIPAD-DKNLIVSTACKVCPSIS--- 71
Cdd:PRK01212   1 MMMVKVRVPATSANLGPGFDSLGLALSLYDEVLVGDVVSveaefSIEVIGEGADKLPLDpEKNLVYQAALKFLEKLGkpp 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534752  72 PHIIEVTSNIPLTRGLGSSASAIVAGIELANQLGNLNLTADQKVQIATNFEGHPDNVAASILGGTVIGALDGKDVSVVRI 151
Cdd:PRK01212  81 GLRIELEKNIPLGRGLGSSAASIVAGLVAANELAGLPLSKEELLQLATEGEGHPDNVAPALLGGLVLALEENGVISVKIP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534752 152 ESKELGVVSLIPNEELNTDESRSVLPKMFPFHEAVKASAISNVLVAALCQKRWEVVGEMMErDHFHEPYRLELVPLLPSI 231
Cdd:PRK01212 161 VFDDLKWVVAIPNIELSTAEARAVLPKQYSLKDAVFNSSRAALLVAALYTGDYELAGRAMK-DVLHEPYRAKLIPGFAEV 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446534752 232 RKCAKEFGAYGTALSGAGPSIFILAPYEKRQEIAGQLARVFT---DMKVCELEIDHKGIIV 289
Cdd:PRK01212 240 RQAALEAGALGAGISGAGPTVFALCDKEDAEKVADALQKAFLqgiEGFVHVLRLDTAGARV 300
ThrB COG0083
Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the ...
 4-292 1.47e-117

Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the Pathway/BioSystem: Threonine biosynthesis


Pssm-ID: 439853 [Multi-domain]  Cd Length: 302  Bit Score: 339.77  E-value: 1.47e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534752   4 FSVRVPASTANVGPGFDSVGIALSLYLDVVVKE-KADKWQVIHS--FEESIPADDKNLIVSTACKVC----PSISPHIIE 76
Cdd:COG0083    3 VKVRVPATSANLGPGFDSLGLALSLYDEVEVERsDEPGLEIEIEgeGADELPTDEDNLVYQAALALLeklgKEPPGLRIE 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534752  77 VTSNIPLTRGLGSSASAIVAGIELANQLGNLNLTADQKVQIATNFEGHPDNVAASILGGTVIGALDGKDVSVVRIE-SKE 155
Cdd:COG0083   83 IEKGIPLGRGLGSSAAAIVAGLVAANALLGLPLSKEELLELATEGEGHPDNVAPALLGGLVLSRSDGEPVRVVRLPvPPD 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534752 156 LGVVSLIPNEELNTDESRSVLPKMFPFHEAVKASAISNVLVAALCQKRWEVVGEMMErDHFHEPYRLELVPLLPSIRKCA 235
Cdd:COG0083  163 LKAVVVIPDFELSTKEARAVLPKQVPLKDAVFNSSRAALLVAALATGDYELLGRAME-DRLHEPYRAKLIPGFDEVKEAA 241

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446534752 236 KEFGAYGTALSGAGPSIFILAPYEKRQEIAGQLARVFTDM----KVCELEIDHKGIIVNKE 292
Cdd:COG0083  242 LEAGALGAGISGAGPTVLALADDEEAEAVAEAMKAAFAEAgidaRVYVLKIDNEGARVLES 302
thrB TIGR00191
homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine ...
 4-289 2.63e-81

homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine kinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.P.aeruginosa homoserine kinase seems not to be homologous (see PROSITE:PDOC0054) [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 129295 [Multi-domain]  Cd Length: 302  Bit Score: 247.70  E-value: 2.63e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534752    4 FSVRVPASTANVGPGFDSVGIALSLYLDVVVKE---KADKWQVIHS---FEESIPAD-DKNLIVSTACKVCP----SISP 72
Cdd:TIGR00191   1 FRVKVPASSANLGPGFDVLGAALSLYLGLTVTDvvaQESDDTEIEAegeGVEKIPTEpTDNLIYQVAKRFLDqlgiRMPP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534752   73 HIIEVTSNIPLTRGLGSSASAIVAGIELANQLGNLNLTADQKVQIATNFEGHPDNVAASILGGTVIGALDGKDVSVVRIE 152
Cdd:TIGR00191  81 VKVTLEKNIPLGRGLGSSAAAIVAALAAANELCGLPLSKERLLDYASELEGHPDNVAPALLGGFQLAFVEDDKLEVLKIP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534752  153 SK-ELGVVSLIPNEELNTDESRSVLPKMFPFHEAVKASAISNVLVAALCQKRWEVVGEMMeRDHFHEPYRLELVPLLPSI 231
Cdd:TIGR00191 161 IFsKLDWVLAIPNIEVSTAEARAVLPKAYPRQDLVFNLSHLAGLVHAIYQKKPDLGAIMM-KDRIHQPYRESLIPNLFKI 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446534752  232 RKCAKEFGAYGTALSGAGPSIFILAP----YEKRQEIAGQLARVFTDMKVCELEIDHKGIIV 289
Cdd:TIGR00191 240 KQAALEKGAYGITISGSGPTILAMADeefaEQKEQDLLEVLHKQGIEGTVHVLDFDNDGARV 301
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 75-135 4.96e-12

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 60.25  E-value: 4.96e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446534752   75 IEVTSNIPLTRGLGSSASAIVAGIELANQLGNLNL-----TADQKVQIAtnfEGHPDNVAASILGG 135
Cdd:pfam00288   2 IEIESNIPLGAGLGSSAALAVALLLALNELFGLPLaklalEAEELAGGG---RGGGMDVAASLYGG 64
 
Name Accession Description Interval E-value
PRK01212 PRK01212
homoserine kinase; Provisional
 1-289 2.14e-125

homoserine kinase; Provisional


Pssm-ID: 234920 [Multi-domain]  Cd Length: 301  Bit Score: 359.85  E-value: 2.14e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534752   1 MIPFSVRVPASTANVGPGFDSVGIALSLYLDVVVKEKAD-----KWQVIHSFEESIPAD-DKNLIVSTACKVCPSIS--- 71
Cdd:PRK01212   1 MMMVKVRVPATSANLGPGFDSLGLALSLYDEVLVGDVVSveaefSIEVIGEGADKLPLDpEKNLVYQAALKFLEKLGkpp 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534752  72 PHIIEVTSNIPLTRGLGSSASAIVAGIELANQLGNLNLTADQKVQIATNFEGHPDNVAASILGGTVIGALDGKDVSVVRI 151
Cdd:PRK01212  81 GLRIELEKNIPLGRGLGSSAASIVAGLVAANELAGLPLSKEELLQLATEGEGHPDNVAPALLGGLVLALEENGVISVKIP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534752 152 ESKELGVVSLIPNEELNTDESRSVLPKMFPFHEAVKASAISNVLVAALCQKRWEVVGEMMErDHFHEPYRLELVPLLPSI 231
Cdd:PRK01212 161 VFDDLKWVVAIPNIELSTAEARAVLPKQYSLKDAVFNSSRAALLVAALYTGDYELAGRAMK-DVLHEPYRAKLIPGFAEV 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446534752 232 RKCAKEFGAYGTALSGAGPSIFILAPYEKRQEIAGQLARVFT---DMKVCELEIDHKGIIV 289
Cdd:PRK01212 240 RQAALEAGALGAGISGAGPTVFALCDKEDAEKVADALQKAFLqgiEGFVHVLRLDTAGARV 300
ThrB COG0083
Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the ...
 4-292 1.47e-117

Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the Pathway/BioSystem: Threonine biosynthesis


Pssm-ID: 439853 [Multi-domain]  Cd Length: 302  Bit Score: 339.77  E-value: 1.47e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534752   4 FSVRVPASTANVGPGFDSVGIALSLYLDVVVKE-KADKWQVIHS--FEESIPADDKNLIVSTACKVC----PSISPHIIE 76
Cdd:COG0083    3 VKVRVPATSANLGPGFDSLGLALSLYDEVEVERsDEPGLEIEIEgeGADELPTDEDNLVYQAALALLeklgKEPPGLRIE 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534752  77 VTSNIPLTRGLGSSASAIVAGIELANQLGNLNLTADQKVQIATNFEGHPDNVAASILGGTVIGALDGKDVSVVRIE-SKE 155
Cdd:COG0083   83 IEKGIPLGRGLGSSAAAIVAGLVAANALLGLPLSKEELLELATEGEGHPDNVAPALLGGLVLSRSDGEPVRVVRLPvPPD 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534752 156 LGVVSLIPNEELNTDESRSVLPKMFPFHEAVKASAISNVLVAALCQKRWEVVGEMMErDHFHEPYRLELVPLLPSIRKCA 235
Cdd:COG0083  163 LKAVVVIPDFELSTKEARAVLPKQVPLKDAVFNSSRAALLVAALATGDYELLGRAME-DRLHEPYRAKLIPGFDEVKEAA 241

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446534752 236 KEFGAYGTALSGAGPSIFILAPYEKRQEIAGQLARVFTDM----KVCELEIDHKGIIVNKE 292
Cdd:COG0083  242 LEAGALGAGISGAGPTVLALADDEEAEAVAEAMKAAFAEAgidaRVYVLKIDNEGARVLES 302
thrB TIGR00191
homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine ...
 4-289 2.63e-81

homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine kinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.P.aeruginosa homoserine kinase seems not to be homologous (see PROSITE:PDOC0054) [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 129295 [Multi-domain]  Cd Length: 302  Bit Score: 247.70  E-value: 2.63e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534752    4 FSVRVPASTANVGPGFDSVGIALSLYLDVVVKE---KADKWQVIHS---FEESIPAD-DKNLIVSTACKVCP----SISP 72
Cdd:TIGR00191   1 FRVKVPASSANLGPGFDVLGAALSLYLGLTVTDvvaQESDDTEIEAegeGVEKIPTEpTDNLIYQVAKRFLDqlgiRMPP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534752   73 HIIEVTSNIPLTRGLGSSASAIVAGIELANQLGNLNLTADQKVQIATNFEGHPDNVAASILGGTVIGALDGKDVSVVRIE 152
Cdd:TIGR00191  81 VKVTLEKNIPLGRGLGSSAAAIVAALAAANELCGLPLSKERLLDYASELEGHPDNVAPALLGGFQLAFVEDDKLEVLKIP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534752  153 SK-ELGVVSLIPNEELNTDESRSVLPKMFPFHEAVKASAISNVLVAALCQKRWEVVGEMMeRDHFHEPYRLELVPLLPSI 231
Cdd:TIGR00191 161 IFsKLDWVLAIPNIEVSTAEARAVLPKAYPRQDLVFNLSHLAGLVHAIYQKKPDLGAIMM-KDRIHQPYRESLIPNLFKI 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446534752  232 RKCAKEFGAYGTALSGAGPSIFILAP----YEKRQEIAGQLARVFTDMKVCELEIDHKGIIV 289
Cdd:TIGR00191 240 KQAALEKGAYGITISGSGPTILAMADeefaEQKEQDLLEVLHKQGIEGTVHVLDFDNDGARV 301
PTZ00299 PTZ00299
homoserine kinase; Provisional
 5-257 6.41e-33

homoserine kinase; Provisional


Pssm-ID: 140320  Cd Length: 336  Bit Score: 123.46  E-value: 6.41e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534752   5 SVRVPASTANVGPGFDSVGIALSLYLDVVVkEKADKWQVIHSFE--ESIPADDKNLIVSTACKVCP-----SISPHIIEV 77
Cdd:PTZ00299   9 VLRVPATTANIGPAYDTLGMALSIFMELTV-EHADAFSMTVEGEgsEHISTDEDNMVVQACRLAFEeyahkSMPPLKFIM 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534752  78 TSNIPLTRGLGSSASAIVAGIELANQLGNLNLTADQK---VQIATNFEGHPDNVAASILGGTVIG-ALDGKDVSVVRIES 153
Cdd:PTZ00299  88 HSNIPYGCGCGSSSAAAVAGFVAGMKLCGLTMETENEealLQAIAKFEGHPDNAAPAIYGGIQLVyKKDNGRFLTYRVPT 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534752 154 K-ELGVVSLIPNE--ELNTDESRSVLPKMFPFHEAVKASAISNVLVAALCQKRWEVVGEMmeRDHFHEPYRLElvPLLPS 230
Cdd:PTZ00299 168 PpNLSVVLFVPHNkmKANTHVTRNLIPTSVSLEDAVFNISRTSILVLALSTGDLRMLKSC--SDKLHEQQRSD--ALFPH 243

                        250       260       270
                 ....*....|....*....|....*....|
gi 446534752 231 IRKC---AKEFGAYGTALSGAGPSIFILAP 257
Cdd:PTZ00299 244 FRPCvkaAREAGAHYAFLSGAGPSVCALVG 273
PLN02451 PLN02451
homoserine kinase
 9-272 8.32e-27

homoserine kinase


Pssm-ID: 215248  Cd Length: 370  Bit Score: 107.57  E-value: 8.32e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534752   9 PASTANVGPGFDSVGIALSLYLDVVVKEkadkwqVIHSFE------ESIPADDKNL----------IVSTACKVCPSISP 72
Cdd:PLN02451  59 PATVANLGPGFDFLGCAVDGLGDFVTAR------VDPGVRpgevsiSEITGDTGRLskdplrncagIAAIATMKLLGIRS 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534752  73 HIIEVTSN--IPLTRGLGSSASAIVAGIELANQLGNLNLTADQKVQIATNFEG-----HPDNVAASILGGTV-IGALDGK 144
Cdd:PLN02451 133 VGLSLSLHkgLPLGSGLGSSAASAAAAAVAVNELFGSPLGKDDLVLAGLESEAkvsgyHADNIAPALMGGFVlIRSYEPL 212

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534752 145 DVSVVRIES-KELGVVSLIPNEELNTDESRSVLPKMFPFHEAVKASAISNVLVAALCQKRWEVVGEMMERDHFHEPYRLE 223
Cdd:PLN02451 213 HLIPLRFPSaKDLFFVLVSPDFEAPTKKMRAALPKEIPMKHHVWNCSQAAALVAAILQGDAVLLGEALSSDKIVEPTRAP 292

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 446534752 224 LVPLLPSIRKCAKEFGAYGTALSGAGPS-IFILAPYEKRQEIAGQLARVF 272
Cdd:PLN02451 293 LIPGMEAVKKAALEAGAYGCTISGAGPTaVAVIDDEEKGEEVGERMVEAF 342
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 75-135 4.96e-12

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 60.25  E-value: 4.96e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446534752   75 IEVTSNIPLTRGLGSSASAIVAGIELANQLGNLNL-----TADQKVQIAtnfEGHPDNVAASILGG 135
Cdd:pfam00288   2 IEIESNIPLGAGLGSSAALAVALLLALNELFGLPLaklalEAEELAGGG---RGGGMDVAASLYGG 64
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 21-249 4.68e-09

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 56.00  E-value: 4.68e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534752  21 SVGIALSLYLDVVVKEKADKWQVIHSFEESIPADDKNLI----------VSTACKVCPSISPHI-IEVTSNIPLTRGLGS 89
Cdd:COG1577   19 AIAVAVDRRATVTVEPSDDDKLRIESPDLGGTLDLDPLAdaalryikaaIEAALEYLGLPLKGFdIEIDSEIPRKRGLGS 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534752  90 SASAIVAGIELANQLGNLNLTADQKVQIA--TNFEGHP-----DNvAASILGGTVigALDGKDvSVVRIESKELGVVSLI 162
Cdd:COG1577   99 SAAVAVAVIRALAAFYGVELSKEELFKLAleAEKIVHGnpsglDT-AASTYGGPI--YYQRGD-RAEPLELPKNLPLVVG 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534752 163 pneelNTDESRS-------VLPKM----FPFHEAVKASA-ISNVLVAALCQKRWEVVGEMMERDHFHepyRLEL---VPL 227
Cdd:COG1577  175 -----DTGVPAStkelvakVRKLKernpELYEAFLEEIGdLVEEAIEALEEGDLEALGELMNENHGL---LRALgvsTPE 246

                        250       260
                 ....*....|....*....|..
gi 446534752 228 LPSIRKCAKEFGAYGTALSGAG 249
Cdd:COG1577  247 LDRLVEAARKAGALGAKLTGAG 268
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
 18-249 1.67e-07

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 51.52  E-value: 1.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534752   18 GFDSVGIALSLYLDVVVKEKADkWQVIHSFEESIPADD-----KNLIVSTAC----KVCPSISPHIIEVTSNIPLTRGLG 88
Cdd:TIGR00549  16 GEPAIAAPIPLRTTVTVIESSD-GSFIESDLGRGSLDDapdelDGLKYVLAEflsrFSELNPPPLEITIESEIPPGRGLG 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534752   89 SSASAIVAGIELANQLGNLNLTADQKVQIATNFE----GHP---DNvAASILGGTVigaLDGKDVSVVRIESKELGVVSL 161
Cdd:TIGR00549  95 SSAAVAVALIRALADYFGSELSKEELAELANEAEkiahGKPsgiDT-ATSTSGGPV---YFEKGEGEFTKLISLDGYFVI 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534752  162 IpneelNTDESRS---------VLPKMFPfhEAVKAS-----AISNVLVAALCQKRWEVVGEMMERDHfhepyrlEL--- 224
Cdd:TIGR00549 171 A-----DTGVSGStkeavarvrQLLERFP--ELIDSImdaigELTLEAKAALQDGDVESLGELMNINQ-------GLlka 236

                         250       260
                  ....*....|....*....|....*....
gi 446534752  225 ----VPLLPSIRKCAKEFGAYGTALSGAG 249
Cdd:TIGR00549 237 lgvsHPKLDQLVEIARKAGALGAKLTGAG 265
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 195-272 2.17e-06

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 45.15  E-value: 2.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534752  195 LVAALCQKRWEVVGEMMERDHF-HEP--YRLELVPLLPSIRKCAKEFGaYGTALSGA--GPSIFILAPYEKR-QEIAGQL 268
Cdd:pfam08544   1 LLEALLRGDLEELGKLLTESAEsLEPllVVGILPPELDELLEALLELG-LGAKLSGSggGPTVFALFKDEDDaEEVARAL 79


                  ....
gi 446534752  269 ARVF 272
Cdd:pfam08544  80 REAG 83
PRK03926 PRK03926
mevalonate kinase; Provisional
 53-265 3.37e-06

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 47.74  E-value: 3.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534752  53 ADDKNLIVSTACKVCPSISPH---IIEVTSNIPLTRGLGSSASAIVAGIELANQLGNLNLTADQ------KVQIATNFEG 123
Cdd:PRK03926  53 TGEKHPYVSAAIEKMREEADKdgvTVSITSQIPVGSGLGSSAAVTVATIGALNRLLGLGLSLEEiaklghKVELLVQGAA 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534752 124 HPDNVAASILGGTVIgALDGKdvsvvRIESKELGVV-----SLIPNEEL--NTDESRSVLPKMF-PFHEAV-KASAISNV 194
Cdd:PRK03926 133 SPTDTYVSTMGGFVT-IPDRK-----KLPFPECGIVvgytgSSGSTKELvaNVRKLKEEYPELIePILSSIgKISEKGEE 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534752 195 LVaalCQKRWEVVGEMMERDHfhepyRL---------ELVPLLPSIRKCakefGAYGTALSGAGPS--IFILAPYEKRQE 263
Cdd:PRK03926 207 LI---LSGDYVSLGELMNINQ-----GLldalgvstkELSELIYAARTA----GALGAKITGAGGGgcMVALAAPEKQSE 274


                 ..
gi 446534752 264 IA 265
Cdd:PRK03926 275 VA 276
PRK03817 PRK03817
galactokinase; Provisional
 70-118 6.46e-04

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 40.75  E-value: 6.46e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 446534752  70 ISPHIIEVTSNIPLTRGLGSSASAIVAGIELANQLGNLNLTADQKVQIA 118
Cdd:PRK03817  84 VGGVKGKVSSNLPIGAGLSSSASLEVAVAYALNEAYNLNLSKLELALLA 132
PRK14613 PRK14613
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
157-275 1.39e-03

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;


Pssm-ID: 173077 [Multi-domain]  Cd Length: 297  Bit Score: 39.50  E-value: 1.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534752 157 GVVSLIPnEELNTDESRSVLPKmfPFHEAVKA---SAISNVLVAALCQKRWEVVGEMMERDHfhEPYRLELVPLLPSIRK 233
Cdd:PRK14613 173 GILALTP-QVMNTGEMYALLKK--PLQESASQkngNTLSEDLISSLKVGDWVSLQGRLENDF--EPVAFQLHPELGVLKD 247

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 446534752 234 CAKEFGAYGTALSGAGPSIFILAP-YEKRQEIAGQLARVFTDM 275
Cdd:PRK14613 248 KFLEFGSSYCSLTGSGSSMYGLVQgLEIQEELLPRLRQEFSNL 290
PduX COG4542
PduX protein involved in propanediol utilization and related proteins [Secondary metabolites ...
 75-247 1.54e-03

PduX protein involved in propanediol utilization and related proteins [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 443608 [Multi-domain]  Cd Length: 286  Bit Score: 39.45  E-value: 1.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534752  75 IEVTSNIPLTRGLGSSASAIVAGIELANQLGNLNLTADQKVQIATNFEG-----HPDNVAASILGGTVIGALDgkdvsvv 149
Cdd:COG4542   73 IELRSDIPVGKGMASSTADIAATARAVARALGKELSPEELARLAVAIEPtdstmFPGLVLFDHREGRVLEPLG------- 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446534752 150 riESKELGVVSLIPNEELNTDE-SRSVLPKMFPFHEAVKASAIsNVLVAALCQKRWEVVGEMMERDHF----HEPYrlel 224
Cdd:COG4542  146 --PLPPLDILGLDSGGTVDTLAfNRRDLAELNRAEEPEIERAL-ALLREALRTGDLALLGEAATLSARanqrILPK---- 218

                        170       180
                 ....*....|....*....|....*
gi 446534752 225 vPLLPSIRKCAKEFGAYG--TALSG 247
Cdd:COG4542  219 -PELEELLALAEELGALGvnVAHSG 242
PRK04181 PRK04181
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 69-118 9.02e-03

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 235243  Cd Length: 257  Bit Score: 36.86  E-value: 9.02e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 446534752  69 SISPHIIEVTSNIPLTRGLGSSASAIVAGIELANQLGNLNLTADQKVQIA 118
Cdd:PRK04181  83 FFKKKAIEVEKNIPTGAGLGGGSSDAATFLLMLNEILNLKLSLEELAEIG 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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