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Conserved domains on  [gi|446276758|ref|WP_000354613|]
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MULTISPECIES: acetyl-CoA carboxylase biotin carboxyl carrier protein [Vibrio]

Protein Classification

acetyl-CoA carboxylase biotin carboxyl carrier protein( domain architecture ID 11423502)

acetyl-CoA carboxylase biotin carboxyl carrier protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA

CATH:  2.40.50.100
Gene Ontology:  GO:0003989|GO:0006633|GO:0009317
PubMed:  1370469
SCOP:  4002909
TCDB:  3.B.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AccB COG0511
Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier ...
 9-153 6.16e-57

Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


:

Pssm-ID: 440277 [Multi-domain]  Cd Length: 136  Bit Score: 174.31  E-value: 6.16e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446276758   9 LIELVEESGIAELEISEGEESVRISRYGQPAPAPQVhyaaapapvAAPAPVAQAAAVAEAPAAAKVPAGHKVLSPMVGTF 88
Cdd:COG0511    1 LIELLEESGLTELEVEEGEYKVRIKRGGAAAAAPVA---------APAAAAPAAAAPAAAAAAAAASGGGAVKSPMVGTF 71

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446276758  89 YRSPSPDAKAFIEVGQSVSVGDTLCIVEAMKMMNQIEADKSGVVTAILVEDGQTVEFDQPLVVIE 153
Cdd:COG0511   72 YRAPSPGAKPFVKVGDKVKAGDTLCIIEAMKMMNEIEAPVSGTVVEILVENGQPVEYGQPLFVIE 136
 
Name Accession Description Interval E-value
AccB COG0511
Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier ...
 9-153 6.16e-57

Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440277 [Multi-domain]  Cd Length: 136  Bit Score: 174.31  E-value: 6.16e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446276758   9 LIELVEESGIAELEISEGEESVRISRYGQPAPAPQVhyaaapapvAAPAPVAQAAAVAEAPAAAKVPAGHKVLSPMVGTF 88
Cdd:COG0511    1 LIELLEESGLTELEVEEGEYKVRIKRGGAAAAAPVA---------APAAAAPAAAAPAAAAAAAAASGGGAVKSPMVGTF 71

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446276758  89 YRSPSPDAKAFIEVGQSVSVGDTLCIVEAMKMMNQIEADKSGVVTAILVEDGQTVEFDQPLVVIE 153
Cdd:COG0511   72 YRAPSPGAKPFVKVGDKVKAGDTLCIIEAMKMMNEIEAPVSGTVVEILVENGQPVEYGQPLFVIE 136
BCCP TIGR00531
acetyl-CoA carboxylase, biotin carboxyl carrier protein; This model is designed to identify ...
 1-153 2.65e-54

acetyl-CoA carboxylase, biotin carboxyl carrier protein; This model is designed to identify biotin carboxyl carrier protein as a peptide of acetyl-CoA carboxylase. Scoring below the trusted cutoff is a related protein encoded in a region associated with polyketide synthesis in the prokaryote Saccharopolyspora hirsuta, and a reported chloroplast-encoded biotin carboxyl carrier protein that may be highly derived from the last common ancestral sequence. Scoring below the noise cutoff are biotin carboxyl carrier domains of other enzymes such as pyruvate carboxylase.The gene name is accB or fabE. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 273123 [Multi-domain]  Cd Length: 155  Bit Score: 168.09  E-value: 2.65e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446276758    1 MDIRKIKKLIELVEESGIAELEISEGEESVRISRYGQPA--PAPQVHYAAAPAPVAAPAPVAQAAAVAEAPAAAKVPAGH 78
Cdd:TIGR00531   1 MNIREIKELIKLVEESGITELELKEEEFSVRLSKAAAAAsfSVVQQAAAPVPAQVPAQSSAAVPAPAPAAPAPAADIKGH 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446276758   79 KVLSPMVGTFYRSPSPDAKAFIEVGQSVSVGDTLCIVEAMKMMNQIEADKSGVVTAILVEDGQTVEFDQPLVVIE 153
Cdd:TIGR00531  81 IVRSPMVGTFYRAPSPDAKPFVEVGDKVNKGQTVCIVEAMKMMNEIEAEKAGTVVAILVENGQPVEYGEPLIVIE 155
PLN02983 PLN02983
biotin carboxyl carrier protein of acetyl-CoA carboxylase
 82-153 4.78e-30

biotin carboxyl carrier protein of acetyl-CoA carboxylase


Pssm-ID: 215533 [Multi-domain]  Cd Length: 274  Bit Score: 109.93  E-value: 4.78e-30
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446276758  82 SPMVGTFYRSPSPDAKAFIEVGQSVSVGDTLCIVEAMKMMNQIEADKSGVVTAILVEDGQTVEFDQPLVVIE 153
Cdd:PLN02983 202 SPMAGTFYRSPAPGEPPFVKVGDKVQKGQVVCIIEAMKLMNEIEADQSGTIVEILAEDGKPVSVDTPLFVIE 273
biotinyl_domain cd06850
The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all ...
 80-152 8.21e-25

The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, oxaloacetate decarboxylase, methylmalonyl-CoA decarboxylase, transcarboxylase and urea amidolyase. This domain functions in transferring CO2 from one subsite to another, allowing carboxylation, decarboxylation, or transcarboxylation. During this process, biotin is covalently attached to a specific lysine.


Pssm-ID: 133459 [Multi-domain]  Cd Length: 67  Bit Score: 90.17  E-value: 8.21e-25
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446276758  80 VLSPMVGTFYRSpspdakaFIEVGQSVSVGDTLCIVEAMKMMNQIEADKSGVVTAILVEDGQTVEFDQPLVVI 152
Cdd:cd06850    2 VTAPMPGTVVKV-------LVKEGDKVEAGQPLAVLEAMKMENEVTAPVAGVVKEILVKEGDQVEAGQLLVVI 67
Biotin_lipoyl pfam00364
Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue ...
 78-152 4.13e-20

Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue binds biotin in one group and lipoic acid in the other. Note that the HMM does not currently recognize the Glycine cleavage system H proteins.


Pssm-ID: 395290 [Multi-domain]  Cd Length: 73  Bit Score: 78.41  E-value: 4.13e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446276758   78 HKVLSPMVGTFYRSPspDAKAFIEVGQSVSVGDTLCIVEAMKMMNQIEADKSGVVTAILVEDGQTVEFDQPLVVI 152
Cdd:pfam00364   1 TEIKSPMIGESVREG--VVEWLVKVGDKVKAGQPLAEVEAMKMEMEIPAPVAGVVKEILVPEGDTVEVGDPLAKI 73
 
Name Accession Description Interval E-value
AccB COG0511
Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier ...
 9-153 6.16e-57

Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440277 [Multi-domain]  Cd Length: 136  Bit Score: 174.31  E-value: 6.16e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446276758   9 LIELVEESGIAELEISEGEESVRISRYGQPAPAPQVhyaaapapvAAPAPVAQAAAVAEAPAAAKVPAGHKVLSPMVGTF 88
Cdd:COG0511    1 LIELLEESGLTELEVEEGEYKVRIKRGGAAAAAPVA---------APAAAAPAAAAPAAAAAAAAASGGGAVKSPMVGTF 71

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446276758  89 YRSPSPDAKAFIEVGQSVSVGDTLCIVEAMKMMNQIEADKSGVVTAILVEDGQTVEFDQPLVVIE 153
Cdd:COG0511   72 YRAPSPGAKPFVKVGDKVKAGDTLCIIEAMKMMNEIEAPVSGTVVEILVENGQPVEYGQPLFVIE 136
BCCP TIGR00531
acetyl-CoA carboxylase, biotin carboxyl carrier protein; This model is designed to identify ...
 1-153 2.65e-54

acetyl-CoA carboxylase, biotin carboxyl carrier protein; This model is designed to identify biotin carboxyl carrier protein as a peptide of acetyl-CoA carboxylase. Scoring below the trusted cutoff is a related protein encoded in a region associated with polyketide synthesis in the prokaryote Saccharopolyspora hirsuta, and a reported chloroplast-encoded biotin carboxyl carrier protein that may be highly derived from the last common ancestral sequence. Scoring below the noise cutoff are biotin carboxyl carrier domains of other enzymes such as pyruvate carboxylase.The gene name is accB or fabE. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 273123 [Multi-domain]  Cd Length: 155  Bit Score: 168.09  E-value: 2.65e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446276758    1 MDIRKIKKLIELVEESGIAELEISEGEESVRISRYGQPA--PAPQVHYAAAPAPVAAPAPVAQAAAVAEAPAAAKVPAGH 78
Cdd:TIGR00531   1 MNIREIKELIKLVEESGITELELKEEEFSVRLSKAAAAAsfSVVQQAAAPVPAQVPAQSSAAVPAPAPAAPAPAADIKGH 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446276758   79 KVLSPMVGTFYRSPSPDAKAFIEVGQSVSVGDTLCIVEAMKMMNQIEADKSGVVTAILVEDGQTVEFDQPLVVIE 153
Cdd:TIGR00531  81 IVRSPMVGTFYRAPSPDAKPFVEVGDKVNKGQTVCIVEAMKMMNEIEAEKAGTVVAILVENGQPVEYGEPLIVIE 155
PLN02983 PLN02983
biotin carboxyl carrier protein of acetyl-CoA carboxylase
 82-153 4.78e-30

biotin carboxyl carrier protein of acetyl-CoA carboxylase


Pssm-ID: 215533 [Multi-domain]  Cd Length: 274  Bit Score: 109.93  E-value: 4.78e-30
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446276758  82 SPMVGTFYRSPSPDAKAFIEVGQSVSVGDTLCIVEAMKMMNQIEADKSGVVTAILVEDGQTVEFDQPLVVIE 153
Cdd:PLN02983 202 SPMAGTFYRSPAPGEPPFVKVGDKVQKGQVVCIIEAMKLMNEIEADQSGTIVEILAEDGKPVSVDTPLFVIE 273
PRK09282 PRK09282
pyruvate carboxylase subunit B; Validated
 6-153 6.89e-26

pyruvate carboxylase subunit B; Validated


Pssm-ID: 236449 [Multi-domain]  Cd Length: 592  Bit Score: 101.84  E-value: 6.89e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446276758   6 IKKLIELVEESGIA-ELEI-SEGEE-SVRISRYGQPAPAPqvhYAAAPAPVAAPAPVAQAAAVAEAPAAAKVPAGHkVLS 82
Cdd:PRK09282 452 EPKEAAAAGAEGIPtEFKVeVDGEKyEVKIEGVKAEGKRP---FYLRVDGMPEEVVVEPLKEIVVGGRPRASAPGA-VTS 527

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446276758  83 PMVGTFYrspspdaKAFIEVGQSVSVGDTLCIVEAMKMMNQIEADKSGVVTAILVEDGQTVEFDQPLVVIE 153
Cdd:PRK09282 528 PMPGTVV-------KVKVKEGDKVKAGDTVLVLEAMKMENEIQAPVDGTVKEILVKEGDRVNPGDVLMEIE 591
biotinyl_domain cd06850
The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all ...
 80-152 8.21e-25

The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, oxaloacetate decarboxylase, methylmalonyl-CoA decarboxylase, transcarboxylase and urea amidolyase. This domain functions in transferring CO2 from one subsite to another, allowing carboxylation, decarboxylation, or transcarboxylation. During this process, biotin is covalently attached to a specific lysine.


Pssm-ID: 133459 [Multi-domain]  Cd Length: 67  Bit Score: 90.17  E-value: 8.21e-25
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446276758  80 VLSPMVGTFYRSpspdakaFIEVGQSVSVGDTLCIVEAMKMMNQIEADKSGVVTAILVEDGQTVEFDQPLVVI 152
Cdd:cd06850    2 VTAPMPGTVVKV-------LVKEGDKVEAGQPLAVLEAMKMENEVTAPVAGVVKEILVKEGDQVEAGQLLVVI 67
PRK07051 PRK07051
biotin carboxyl carrier domain-containing protein;
78-153 1.40e-24

biotin carboxyl carrier domain-containing protein;


Pssm-ID: 180811 [Multi-domain]  Cd Length: 80  Bit Score: 90.07  E-value: 1.40e-24
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446276758  78 HKVLSPMVGTFYRSPSPDAKAFIEVGQSVSVGDTLCIVEAMKMMNQIEADKSGVVTAILVEDGQTVEFDQPLVVIE 153
Cdd:PRK07051   4 HEIVSPLPGTFYRRPSPDAPPYVEVGDAVAAGDVVGLIEVMKQFTEVEAEAAGRVVEFLVEDGEPVEAGQVLARIE 79
Biotin_lipoyl pfam00364
Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue ...
 78-152 4.13e-20

Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue binds biotin in one group and lipoic acid in the other. Note that the HMM does not currently recognize the Glycine cleavage system H proteins.


Pssm-ID: 395290 [Multi-domain]  Cd Length: 73  Bit Score: 78.41  E-value: 4.13e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446276758   78 HKVLSPMVGTFYRSPspDAKAFIEVGQSVSVGDTLCIVEAMKMMNQIEADKSGVVTAILVEDGQTVEFDQPLVVI 152
Cdd:pfam00364   1 TEIKSPMIGESVREG--VVEWLVKVGDKVKAGQPLAEVEAMKMEMEIPAPVAGVVKEILVPEGDTVEVGDPLAKI 73
Biotinyl_lipoyl_domains cd06663
Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the ...
 96-152 1.15e-16

Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl, or methylamine, respectively, between components of the complex/protein via a biotinyl or lipoyl group, which is covalently attached to a highly conserved lysine residue.


Pssm-ID: 133456 [Multi-domain]  Cd Length: 73  Bit Score: 69.78  E-value: 1.15e-16
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446276758  96 AKAFIEVGQSVSVGDTLCIVEAMKMMNQIEADKSGVVTAILVEDGQTVEFDQPLVVI 152
Cdd:cd06663   17 VKWLKKVGDKVKKGDVLAEIEAMKATSDVEAPKSGTVKKVLVKEGTKVEGDTPLVKI 73
PycA COG1038
Pyruvate carboxylase [Energy production and conversion]; Pyruvate carboxylase is part of the ...
 77-152 3.98e-13

Pyruvate carboxylase [Energy production and conversion]; Pyruvate carboxylase is part of the Pathway/BioSystem: Urea cycle


Pssm-ID: 440660 [Multi-domain]  Cd Length: 1144  Bit Score: 65.49  E-value: 3.98e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446276758   77 GHkVLSPMVGTFyrspspdAKAFIEVGQSVSVGDTLCIVEAMKMMNQIEADKSGVVTAILVEDGQTVEFDQPLVVI 152
Cdd:COG1038  1077 GH-IGAPMPGTV-------VKVLVKEGDEVKKGDPLLTIEAMKMETTITAPRDGTVKEVLVKEGDQVEAGDLLIEL 1144
PRK14040 PRK14040
oxaloacetate decarboxylase subunit alpha;
77-152 8.62e-13

oxaloacetate decarboxylase subunit alpha;


Pssm-ID: 237592 [Multi-domain]  Cd Length: 593  Bit Score: 64.57  E-value: 8.62e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446276758  77 GHKVLSPMVGTFYrspspdaKAFIEVGQSVSVGDTLCIVEAMKMMNQIEADKSGVVTAILVEDGQTVEFDQPLVVI 152
Cdd:PRK14040 524 GEPVTAPLAGNIF-------KVIVTEGQTVAEGDVLLILEAMKMETEIRAAQAGTVRGIAVKEGDAVAVGDTLLTL 592
PRK12999 PRK12999
pyruvate carboxylase; Reviewed
 77-153 1.22e-11

pyruvate carboxylase; Reviewed


Pssm-ID: 237263 [Multi-domain]  Cd Length: 1146  Bit Score: 61.31  E-value: 1.22e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446276758   77 GHkVLSPMVGTFyrspspdAKAFIEVGQSVSVGDTLCIVEAMKMMNQIEADKSGVVTAILVEDGQTVEFDQPLVVIE 153
Cdd:PRK12999 1077 GH-VGAPMPGSV-------VTVLVKEGDEVKAGDPLAVIEAMKMETTITAPVDGTVKRVLVKAGDQVEAGDLLVELE 1145
PRK05641 PRK05641
putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
 80-150 5.42e-11

putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 235540 [Multi-domain]  Cd Length: 153  Bit Score: 57.18  E-value: 5.42e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446276758  80 VLSPMVGTFYRspspdakAFIEVGQSVSVGDTLCIVEAMKMMNQIEADKSGVVTAILVEDGQTVEFDQPLV 150
Cdd:PRK05641  87 VTAPMPGKILR-------ILVREGQQVKVGQGLLILEAMKMENEIPAPKDGVVKKILVKEGDTVDTGQPLI 150
PRK06549 PRK06549
acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
 82-152 3.24e-10

acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 235826 [Multi-domain]  Cd Length: 130  Bit Score: 54.43  E-value: 3.24e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446276758  82 SPMVGTFyrspspdAKAFIEVGQSVSVGDTLCIVEAMKMMNQIEADKSGVVTAILVEDGQTVEFDQPLVVI 152
Cdd:PRK06549  66 SPMPGTI-------LKVLVAVGDQVTENQPLLILEAMKMENEIVASSAGTVTAIHVTPGQVVNPGDGLITI 129
lipoyl_domain cd06849
Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. ...
 99-152 6.80e-10

Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid dehydrogenase (BCDH), contain at least three different enzymes, 2-oxo acid dehydrogenase (E1), dihydrolipoyl acyltransferase (E2) and dihydrolipoamide dehydrogenase (E3) and play a key role in redox regulation. E2, the central component of the complex, catalyzes the transfer of the acyl group of CoA from E1 to E3 via reductive acetylation of a lipoyl group covalently attached to a lysine residue.


Pssm-ID: 133458 [Multi-domain]  Cd Length: 74  Bit Score: 52.02  E-value: 6.80e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446276758  99 FIEVGQSVSVGDTLCIVEAMKMMNQIEADKSGVVTAILVEDGQTVEFDQPLVVI 152
Cdd:cd06849   21 LVKEGDSVEEGDVLAEVETDKATVEVEAPAAGVLAKILVEEGDTVPVGQVIAVI 74
AceF COG0508
Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component ...
 99-152 1.49e-08

Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component [Energy production and conversion]; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440274 [Multi-domain]  Cd Length: 77  Bit Score: 48.91  E-value: 1.49e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446276758  99 FIEVGQSVSVGDTLCIVEAMKMMNQIEADKSGVVTAILVEDGQTVEFDQPLVVI 152
Cdd:COG0508   23 LVKEGDTVKEGDPLAEVETDKATMEVPAPAAGVLLEILVKEGDTVPVGAVIAVI 76
PTZ00144 PTZ00144
dihydrolipoamide succinyltransferase; Provisional
 102-152 2.59e-07

dihydrolipoamide succinyltransferase; Provisional


Pssm-ID: 240289 [Multi-domain]  Cd Length: 418  Bit Score: 48.53  E-value: 2.59e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446276758 102 VGQSVSVGDTLCIVEAMKMMNQIEADKSGVVTAILVEDGQTVEFDQPLVVI 152
Cdd:PTZ00144  68 VGDYVKEDEVICIIETDKVSVDIRAPASGVITKIFAEEGDTVEVGAPLSEI 118
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 99-152 2.00e-05

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 43.01  E-value: 2.00e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446276758  99 FIEVGQSVSVGDTLCIVEAMKMMNQIEADKSGVVTAILVEDGQTVEFDQPLVVI 152
Cdd:PRK14875  23 LVQEGDEVEKGDELLDVETDKITNEVEAPAAGTLRRQVAQEGETLPVGALLAVV 76
PRK08225 PRK08225
acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
 78-153 2.65e-05

acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 181304 [Multi-domain]  Cd Length: 70  Bit Score: 40.16  E-value: 2.65e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446276758  78 HKVLSPMVGTFYrspspdaKAFIEVGQSVSVGDTLCIVEAMKMMNQIEADKSGVVTAILVEDGQTVEFDQPLVVIE 153
Cdd:PRK08225   2 TKVYASMAGNVW-------KIVVKVGDTVEEGQDVVILESMKMEIPIVAEEAGTVKKINVQEGDFVNEGDVLLEIE 70
sucB TIGR01347
2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component); This ...
 102-153 3.88e-05

2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component); This model describes the TCA cycle 2-oxoglutarate system E2 component, dihydrolipoamide succinyltransferase. It is closely related to the pyruvate dehydrogenase E2 component, dihydrolipoamide acetyltransferase. The seed for this model includes mitochondrial and Gram-negative bacterial forms. Mycobacterial candidates are highly derived, differ in having and extra copy of the lipoyl-binding domain at the N-terminus. They score below the trusted cutoff, but above the noise cutoff and above all examples of dihydrolipoamide acetyltransferase. [Energy metabolism, TCA cycle]


Pssm-ID: 273565 [Multi-domain]  Cd Length: 403  Bit Score: 42.41  E-value: 3.88e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 446276758  102 VGQSVSVGDTLCIVEAMKMMNQIEADKSGVVTAILVEDGQTVEFDQPLVVIE 153
Cdd:TIGR01347  24 VGDTVKRDENIVEIETDKVVLEVPSPADGVLQEILFKEGDTVESGQVLAILE 75
PRK14042 PRK14042
pyruvate carboxylase subunit B; Provisional
 100-153 5.75e-05

pyruvate carboxylase subunit B; Provisional


Pssm-ID: 172536 [Multi-domain]  Cd Length: 596  Bit Score: 42.02  E-value: 5.75e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446276758 100 IEVGQSVSVGDTLCIVEAMKMMNQIEADKSGVVTAILVEDGQTVEFDQPLVVIE 153
Cdd:PRK14042 541 VSAGDEVKAGQAVLVIEAMKMETEIKAPANGVVAEILCQKGDKVTPGQVLIRVE 594
PRK11855 PRK11855
dihydrolipoamide acetyltransferase; Reviewed
 99-153 2.33e-04

dihydrolipoamide acetyltransferase; Reviewed


Pssm-ID: 237000 [Multi-domain]  Cd Length: 547  Bit Score: 40.19  E-value: 2.33e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446276758  99 FIEVGQSVSVGDTLCIVEAMKMMNQIEADKSGVVTAILVEDGQTVEFDQPLVVIE 153
Cdd:PRK11855  22 LVKEGDTVEEDQPLVTVETDKATMEIPSPAAGVVKEIKVKVGDTVSVGGLLAVIE 76
PRK11855 PRK11855
dihydrolipoamide acetyltransferase; Reviewed
 99-153 3.46e-04

dihydrolipoamide acetyltransferase; Reviewed


Pssm-ID: 237000 [Multi-domain]  Cd Length: 547  Bit Score: 39.42  E-value: 3.46e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446276758  99 FIEVGQSVSVGDTLCIVEAMKMMNQIEADKSGVVTAILVEDGQTVEFDQPLVVIE 153
Cdd:PRK11855 139 LVKVGDTVEEDQSLITVETDKATMEIPSPVAGVVKEIKVKVGDKVSVGSLLVVIE 193
biotinyl_domain cd06850
The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all ...
 123-153 3.90e-04

The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, oxaloacetate decarboxylase, methylmalonyl-CoA decarboxylase, transcarboxylase and urea amidolyase. This domain functions in transferring CO2 from one subsite to another, allowing carboxylation, decarboxylation, or transcarboxylation. During this process, biotin is covalently attached to a specific lysine.


Pssm-ID: 133459 [Multi-domain]  Cd Length: 67  Bit Score: 36.63  E-value: 3.90e-04
                         10        20        30
                 ....*....|....*....|....*....|.
gi 446276758 123 QIEADKSGVVTAILVEDGQTVEFDQPLVVIE 153
Cdd:cd06850    1 EVTAPMPGTVVKVLVKEGDKVEAGQPLAVLE 31
PRK05704 PRK05704
2-oxoglutarate dehydrogenase complex dihydrolipoyllysine-residue succinyltransferase;
96-153 4.08e-03

2-oxoglutarate dehydrogenase complex dihydrolipoyllysine-residue succinyltransferase;


Pssm-ID: 235571 [Multi-domain]  Cd Length: 407  Bit Score: 36.35  E-value: 4.08e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446276758  96 AKAFIEVGQSVSVGDTLCIVEAMKMMNQIEADKSGVVTAILVEDGQTVEFDQPLVVIE 153
Cdd:PRK05704  20 ATWHKKPGDAVKRDEVLVEIETDKVVLEVPAPAAGVLSEILAEEGDTVTVGQVLGRID 77
PycA COG1038
Pyruvate carboxylase [Energy production and conversion]; Pyruvate carboxylase is part of the ...
 122-153 4.46e-03

Pyruvate carboxylase [Energy production and conversion]; Pyruvate carboxylase is part of the Pathway/BioSystem: Urea cycle


Pssm-ID: 440660 [Multi-domain]  Cd Length: 1144  Bit Score: 36.21  E-value: 4.46e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 446276758  122 NQIEADKSGVVTAILVEDGQTVEFDQPLVVIE 153
Cdd:COG1038  1077 GHIGAPMPGTVVKVLVKEGDEVKKGDPLLTIE 1108
EmrA COG1566
Multidrug resistance efflux pump EmrA [Defense mechanisms];
123-153 5.81e-03

Multidrug resistance efflux pump EmrA [Defense mechanisms];


Pssm-ID: 441174 [Multi-domain]  Cd Length: 331  Bit Score: 35.79  E-value: 5.81e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 446276758 123 QIEADKSGVVTAILVEDGQTVEFDQPLVVIE 153
Cdd:COG1566   47 TVAAKVSGRVTEVLVKEGDRVKKGQVLARLD 77
Biotin_lipoyl_2 pfam13533
Biotin-lipoyl like;
123-153 8.93e-03

Biotin-lipoyl like;


Pssm-ID: 433286  Cd Length: 50  Bit Score: 32.80  E-value: 8.93e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 446276758  123 QIEADKSGVVTAILVEDGQTVEFDQPLVVIE 153
Cdd:pfam13533   4 KIASPVSGKVVAVNVKEGQQVKKGDVLATLD 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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